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<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9L2</accession>
    <name>A0A2T6Z9L2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000701">
        <property type="protein sequence ID" value="PUU72165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9L2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="24242" checksum="1222ABD15F3730A4" modified="2018-07-18" version="1">MGSTLLAGSPLNAPPSRSSASTDPLTLQGRGRSFTIHGAAGSQVAASGEPAVGLARAMTFETCRVRDHILGRTRFKIRLGRRHPGTNRPEETHTSPSMPTGGEDCTSDYQLTVEDMEGDLDMTVRENKLDEREVYEEWEEDEEDQDVDFIDLMKMIYKEEEEKEEEETDDNGDDDNDDNYYDDGEREPSSDSLSQSENSDVDMIHQQKLTFDPHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9R8</accession>
    <name>A0A2T6Z9R8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000701">
        <property type="protein sequence ID" value="PUU72164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9R8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015531800" evidence="1">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="222" mass="23304" checksum="37173602021F0852" modified="2018-07-18" version="1">MAGMMCAAPPVAVFVAPSVAVSVASSVASSGSSVLGFSEGKLRVMSRRRSPPRGTIVREVDDDDDLVMGFVEPIGGPVDAAALQSAIYRQNILCRDRSTEQRVIEVERMVARDGLDPPPPRPIGILALGRDLEFVKWGARRLPVVETNTLEVTPHLCPVAGGGVNGVRCSLRGLRGPKNSGPPVKFPALPCPTAWGGAFLFSLPAPAPVQVPTPFQAPNGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB32</accession>
    <name>A0A2T6ZB32_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000486">
        <property type="protein sequence ID" value="PUU72679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB32"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="19921" checksum="724A1AA044A1A5A4" modified="2018-07-18" version="1">MISHGIEISIAGGVEEMIPGALGMRSRSPFTTAFYAIPSVHRQKDVSIQAFPMALQNSGGVRHAIMKPFYDGVLHHPICPPPKGHPHTSIFHGATESSEGGPDSGGVRHAIMKPLYDGVLHDPICPPPKGHPHTSIFHGATESSEGGIPGALGMRSWSPFMTTFDTIQAVHHQKGVSIEVVFIALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB60</accession>
    <name>A0A2T6ZB60_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000478">
        <property type="protein sequence ID" value="PUU72713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB60"/>
    <dbReference type="OrthoDB" id="5319158at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="106" mass="12147" checksum="3DF3EEF0C81D6999" modified="2018-07-18" version="1">MSPFAGTPDQGPRETMKKGVVAKVNGEAPDKMWIPSKGNLFKKPQSALDGYAKWVVQLWNKILPCEGLRYRITESRRINKECHREDIDPSWIITEHMNCDSLWSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBZ7</accession>
    <name>A0A2T6ZBZ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1136116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBZ7"/>
    <dbReference type="OrthoDB" id="5355583at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="217" mass="24826" checksum="4FAB61B16CA906FC" modified="2018-07-18" version="1">MNTRETEKRLGFHFNEFERDAVSISQMLADVKPEFKELGEEEVMGIKEQIFHYILGFIEIEGYPSEANDNFNKANVNDLVLLVLFPIVRASQGQTGRELRLLREKDIITTNFIGTRDRKFAFIVEAQKASIGQAKRLCMLALKEMGDNNPGGVIHGFVTSGDCWQIIRYQREIFTQTDPVQLVFRTMERDKAKWLKESSIIVDFLNAALRSEGFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC36</accession>
    <name>A0A2T6ZC36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000421">
        <property type="protein sequence ID" value="PUU73043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC36"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="12183" checksum="C8B33D3ABF90A964" modified="2018-07-18" version="1">MVPTSTDRWGASGVPLSTRLACSAFSCSAASVFFSSSSCSSYSAILIYSGSSISLSAYSVALIHPGFSTLSSAVPIRFLFPAFSSNFGLGVYLCLLTLSGITSGSSSSAFLFLDLNSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCB2</accession>
    <name>A0A2T6ZCB2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1117487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCB2"/>
    <dbReference type="OrthoDB" id="5429346at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="212" mass="24152" checksum="15094E14D2E8776A" modified="2018-07-18" version="1">MEIGSPIPTQNRYPRLRLDQMESPPSSPSSSSASSSTAKESSPPPSPSEDDDDSDSDDSLDLLDTLQSDNIEDIPCSQNPARRYYGPRKRPRKAGSPVRRHHGSSAEKEKEPEEEDELSSTQSPPKKKKRERMVNGEGRNGELGAEAASRKPSDWEGEKERMEWEKERKKQRREGMTEESGRGQRGRWMSKRKKKTGREIKHIYTDYIHEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCV0</accession>
    <name>A0A2T6ZCV0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1095311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000388">
        <property type="protein sequence ID" value="PUU73320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCV0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCV0"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="27848" checksum="E67A26B4D4657DA0" modified="2018-07-18" version="1">MQILEVCYKSGVKVVTIYAFSIENFKRPLHEVNALMEIAKIKLSQLCQHGELMDQYGASLRILGHRSLLRQDVLEAIEQATEMTRHNDKAILNVCFPYTSRDEITTAIRDIVSSSTIPQTSPPSPSPSDSSTSTSTSTSSGKTATPGLMDIESITEKTVTRHMFTSGCPPLDLLVRTSGVERLSDFMMWQCHQDTDIVFSDSLWPQFDIWKFLPILINWGVKRRKLEKEKGDVEVRGVGMGMGVGKGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCX5</accession>
    <name>A0A2T6ZCX5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1197009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000390">
        <property type="protein sequence ID" value="PUU73296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCX5"/>
    <dbReference type="OrthoDB" id="5489517at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="197" mass="22953" checksum="4C62E1BBEC102A84" modified="2018-07-18" version="1">MPMLEGAILSQLIGFLRNGTGTNKDFDMVLLQFEKVVHDMAISHFKIPEESVGKFIQEQIQEIHKLFGQVQAIAESYQLWGQTPNYFCKRDIAKPIPEFSPEDEQLVRDLITVMENEESVHDFLNTKPYVDHWGGMGDQDFIDLARRIVIDLNAMHEHADEDNKFMALTRQERIQDLLDLLKKCRGILSVRYYFHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD26</accession>
    <name>A0A2T6ZD26_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000380">
        <property type="protein sequence ID" value="PUU73392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD26"/>
    <dbReference type="OrthoDB" id="5470099at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="281" mass="31033" checksum="1B954914AC18F172" modified="2018-07-18" version="1">MCDPPRPPRRPPPDSGPHSLVVGQPRPLHNTGYLLGPGGPTRPSPESDYFASPAGLGRSRPNTTRPPSPPSTVGFLPMPTRGGGPPSTAGFIPMPYNPGPKHPSSNQFLMPAPEVRPPPTAAQEQAVVELNELSQLVCMEHYHRSTTLDLIPSGRTEGYSVQWQCEMLFWNLKVCVNCGFRRIKCSKMVEERSLLSSGTQLRILGVWEGTVCEHILRLHRIGQLKKDWWKNDVDLTGAEDKMDAKPQYMICAPKHVRCHPPSSKDLGVFLSSAACLFSVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD35</accession>
    <name>A0A2T6ZD35_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Isy1-like splicing family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1163132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000378">
        <property type="protein sequence ID" value="PUU73407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD35"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD35"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="21163" checksum="722B355F3BAE8036" modified="2018-07-18" version="1">MDRNSEKTQSVLFRFGERQVPDLTIVNAERKRRPKMRTEVTAIPAGEKWCGQVVKDISRKVTKIQHPSLSDYQIRDLNCEIYKLMRDGLEVLGSRSNKYFGRARELPRIKELFDELKPSKRSAEGKDQERKLRVEMRRNVDADYYGFNRDEADRPKEVESFRNVERAGEEGAPEGWTPISGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDU9</accession>
    <name>A0A2T6ZDU9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Heat shock factor binding protein 1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1094554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDU9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDU9"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8184" checksum="CB9149902B3F6ED1" modified="2018-07-18" version="1">MSTQGKNETPSNRQENSAAPEEAPAELTAVVDDLLNSLSAKFASVSSEIFEKIEAMSKRLDQMEAQLQQTGTSAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE63</accession>
    <name>A0A2T6ZE63_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE63"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE63"/>
    <dbReference type="OrthoDB" id="102559at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF38">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="19257" checksum="9B69B6EE7D82E5FB" modified="2018-07-18" version="1">MSSVTVASLNRISCERLRTLLLTQHTQPGEEKVVVVDVPSRLNKQDPDHIGGHIKSSRHVPSGSLDYTAAELARQLKGAEKVVFHCLLSQQRGPSAALRYQMERERLFGRGSTVTAGGTKEEEGGEGREGGEEGEVKMQEVLVLDGGFAGWQAKYGNDERLTENYNKELWEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF57</accession>
    <name>A0A2T6ZF57_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000326">
        <property type="protein sequence ID" value="PUU74044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF57"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12687" checksum="F6A59EA337DD72EC" modified="2018-07-18" version="1">MTLSEFFVIVPSLSTEKHAGALPLHLAYVAEKVAKREFYRQCGEYFSPQITSGQTETTPYAGSAFAVVAESEEDVKRQLDNDPFAKEGVWDVAAARIFHFKTGDSVPINYPLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFG8</accession>
    <name>A0A2T6ZFG8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1033534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000312">
        <property type="protein sequence ID" value="PUU74240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFG8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFG8"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="564" mass="60725" checksum="C9BFEDE84D8300E6" modified="2018-07-18" version="1">MQALPEYDYIFALGMIFAFLDAWNIGANDVANSFATSVSSRSLTMMQAMCIATVCEFTGAVVVGARVADTIRSKIVKIDQFIDHPGVLMLGMLCALVGSSTWLTIATALGLPVSTTHCIVGGVIGMGIAALGADGVVWGWEGKGVAQIFASWVIAPAIAAGFAAIIFSITKYGVLKRSEPLKWGFVMVPIYFAITSGILTMLIVWKGAASLNLDDWSAGQIAGCIFGVSGGVALLVVVFFLPFLHRKLIKEDWTMRWWHIFLGPLLLTRGPVPEAPEGVQTQIVQDYYRGKATKGDLEAANVKPSTIAELETSRTDTHSDELGIQKEAGISSRSLEEVERMDTGPWYYPKNLWKIIVDAALHGVRVDVISEQGRSSKLAGDINDMHARAAHFDNKTEHLYSFLQILTAATASFAHGANDVSNATGPLATIYLIWHTGIVDKKAPVPVWVLAYGGAAIVIGLWTYGYNIMRNLGNRLTLQSPSRGFSMELGSAVTVVLATRLALPVSTTQCIVGATMGVALCNGDFKALNWRMVAWCYAGWILTLPIAGIISGCLMGIIINAPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFT4</accession>
    <name>A0A2T6ZFT4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1000897</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFT4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFT4"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="456" mass="51156" checksum="88EAF33D4A820AE8" modified="2018-07-18" version="1">METAAPQTPLFYQIIPATPEQWTPILSKSCTFTQEIFSSAMHEMILNPNYNSSWILRADILSDSPTSALQLEAGIPRPMQIPNFTPNRTILRRFIPRNPQRDAAAEQTCTFYEGSQDRQALVVYQSHSETPEGLPYYLPTVRALAFRYSQDGEDGKSVSIYYRLFPEVPLNNRLERTALHLLTRIHKLGNGFTAGYTKRVHHDQIIPRETFQTTYLALRERHAKRLIGRWVENTDPGKHVFEDILIAAFLIELWKDMGRGLEAGFVDIGCGNGVLVDILIREGYTGWGFDARRRKTWSVLGSSTEQNLHEMVLIPRLLGGSVDDGIHDGVFPAGTFIISNHADELTPWTPLLAKESECPFLMIPCCSHDLSGRRHKQPGKGSQYACLVEWVARLAGDVGWEVEREVLRIPSTRNVGMIGRNMGEGMTVEEALQREGGGSGWSERALALKAGGNKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG14</accession>
    <name>A0A2T6ZG14_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1092891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000300">
        <property type="protein sequence ID" value="PUU74425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG14"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF32">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU74425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="320" mass="34945" checksum="F1A7148218362AB6" modified="2018-07-18" version="1">MAANSMKLLTGNSHPLLARRVADRLGIDLTKVLVVQHSNQETSVTIGESVRDEDVFIIQSTAPGEVNDGLMELLIMINACKTASARRITAVIPNFPYARQDKKDKSRAPISAKLIANMLQTAGCNHVITMDLHASQIQGFFNVPVDNLYAEPSMLRYIRENFDYRNAVIVSPDAGGAKRATAIADRLDLNFALIHKERSRPNEVSRMVLVGDVQNKIAILVDDMADTCGTLVKAAQTLKKHGAQEVVAIVTHGILSGNAIDSINKSEIGRVVVTNTVPHDEKKKRCPKLHTIDIAPTLAEACRRTHNGESVSFLFSHAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG28</accession>
    <name>A0A2T6ZG28_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1000788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000304">
        <property type="protein sequence ID" value="PUU74374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG28"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG28"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="334"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="567" mass="60810" checksum="EE1D19CA30E8D58A" modified="2018-07-18" version="1">MSYPLLRLRRFPRLPLRTATTTTLKHTRTIATHSHPHFESAVSTIRSTVDTSSPEFKENAAQMAAITTSLRSLHERIKLGGSEEAREKHLARKKMLPRDRITALLDPGSAFLELSPLAGHLLYPGEDVPAGGIITGIGRVSGVECMVVVNDSTVKGGTYYPITVKKHIRAQAIAQENRLPCIYLVDSGGANLPHQADVFPDRDHFGRIFYNQARMSADGIPQISVVMGPCTAGGAYVPSMSDESIIVENSGTIFLAGPPLVKAATGEEVTAEALGGGALHSKVSGVTDYLAVSDAHALVLARRCIANLNYPTTTDASSEEAQTIIKDPLYDPKDLNGIASTNLRKPINPHDIISRITDSSAFSEFKRDYGATLVTGFARIHGYPVGILANNGILFSESALKGAHFIQMCAKRRIPLLFLQNISGFMVGSQAEAGGIAKNGAKLVNAVACADVPKFTVVVGASYGAGNYGMCGRAYGPRFLWMWPNARVGVMGAEQLDAVMRTVGKNVDEGLKGRIERESEAVFGSARLWDDGVIAPKDTRAMLGLGLRAAMGGSVRESDTKFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGH7</accession>
    <name>A0A2T6ZGH7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1092436</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="NESQ01000289">
        <property type="protein sequence ID" value="PUU74600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGH7"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
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    <sequence length="960" mass="105257" checksum="50B6F046635523D9" modified="2018-07-18" version="1">MQVANPHGPITSGVSSVSLVAPTEDLFYTTVAFYTDLGFNEAFVYDRTHPTVKREDDHCRASEKETWLYSQGDGGDGTDVNLKIRYVAEALHFKDSNDGPRRQSIIAPSTPLNSKESYDWRGKSMSVILYTQVLDRIIKLLSEKKIAFQSQPNENEPSEVYTHDPLGTLVGFTSKANPFTSVRPRPRLGVSREPGDRDQTRPSTPGKAKKRIAVMTSGGDAPGMNAAVRAVVRMTIAQGCEAYAVYEGYEGLVQGGKLIKRMHWEDVRGWLSEGGTLIGTARCKKFTERAGRLQGAKNLVSAGIDALIVCGGDGSLTGADIFRSEWPGLLTELIKLGELTEEQCASCKTLNIVGLVGSIDNDMSCTDATIGAYSSLTRICQAVDFIDATAYSHSRAFVVEVMGRHCGWLALMAGVSTGADFVFLPEKPPQDKWEKEMCRIIKTHRAAGKRKTIVIVAEGAIDRELKPISATYVRDILVDELRLDTRITTLGHVQRGGTACAFDRILATLQGGEAVKAVLESTPDTPSPMIAINENKITRKPLMDAVRLTKAVAECIKNKDFVGAMNLRDPEFEEYHRAYMATTKPDELSEKAPEDKRMRIAIIHVGAPAGGINAATRAAATYCLNRGHRPLAIHNGFPGLVRHDSVRELDWLTVEGWAIRGGSEIGTNRSLPSEDMGMVAWYFQRYKFDGLLIIGGFEAYHALTELHSARDSYPAFRIPMTCLPATISNNVPGTEFSIGSDTCLNALIEYCDAIKQSASASRRRVFVVECQGGNSGYVATMAGLSVGALAVYTPEEGINLNMLKDDIDHLRESFANDKGMNRAGKLILRNERASKTYTTEIIASIIREEAKTRFESRTAIPGHVQQGGTPSPMDRVRAVRLAVKCIQFLESNKKTPKEVFEDPSTSAVIGVRGASVVFTSIEDLRQVETDWDSRRPKKAFWLDYRDLVDTLSGRSGTPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGR1</accession>
    <name>A0A2T6ZGR1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nonsense-mediated mRNA decay factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1092245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000283">
        <property type="protein sequence ID" value="PUU74646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="MIF4G-like_typ-3"/>
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        <property type="entry name" value="Nmd2/UPF2"/>
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        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MIF4G"/>
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        <property type="entry name" value="ARM repeat"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="503"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="708"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1152"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1182" mass="133979" checksum="BC4E0858A77B79D3" modified="2018-07-18" version="1">MNRARKRELRELNKLAWDGQRDIFKTAGSLDSTLKKNTAVIKRLRTSLDSYQVLLKEIQTVALEKYLPEVIAAVYEGLLKTKTASEIAGAVEVVSALHQRFQKDFTPQFTFTLARGLATPRPDALKGLSPEQKEREEKERFARQRVLLRVGVELYLVGVVRSVQDAVSVDDGVATKGAGGGVKPPGVVNGKDAAKKRDGDGELEPFPLEVLKDLLNRDKDHLNLPLVVLFVKNFPYDTLGVRPRNLTRKNVEEDGATSAEKPANGETMNVDANGTPSLDSTDPPLLSPELQQRFKNILARYLDSVKAHIIRQHKHLQAQSARNAEAYVKSGEIFEDRQANYEKLVKTQEKFIANAQVVADVLGVEMPDLPDEKDGAEPNGDSIIREGGSMFTSREDGSKFGIWEDDDQRRFYEDLIDLRTRGVPAVLLEDGRKKKAEGEAKVEEEVKVDEEKVSIEEEDSVADDDSPGELKDTYASSPTDESNTGNDESTSTTIANKTIGAQVDALLVRLPELTNRDLIDQAAFEFCFLNSKASRNRLLKVLQEVPRGRQDLLPYYARLIATLNKYLPDIGKGMVEYLDKEFRSLQRRKDKELSEVRSRNVRYLSELTKFGIVPQHIIFHCLKVALEDFHKINIDVICNTLENCGKYLLRSPETGGRMATFLETLKRKKDGVQYLGPQERVAIENAFYYVNPPERPAIAQKERTVMELFVRKLIYLDLTKRNYVKILKQLRKLHWDDEEVVSLLFKVFTKIWRVRYNNVHILAILVGALGRYHQDFAYSVIDEVLEQISLGLEQNNFKHNQRRIAQVKYLGELYNYKLVDSPVIFDALYRIVTFGHEGGTPRPGKICPLDMPDDFFRIRLVCTLLDVCGMCFDKGSAKKKLDFFLTFFQYYIFTKDPLSMDIEFIIQDTFAQIRPSWSLYTNLEEAGKAFEEAVQKTYKPDEEENKSVGDQDEVDEAESVSDGEQRGRYQDEEHSDEEDEPPAPVIAPEQHEESEEDTSSEDEEDIVVKLEEEERDPEAEAEFDRELAKLMQESVDARKFERKPLFDVPLPIKRGGSTLSREATFDSDAGDNLASSPPPSGGGMMAFSLLTKKGNRQQTKVVELPSDSSLAMAMKNTQEAERAEKMKIKELVMSYDRMEETSEIESLERHAVASGTHIKYEKGSGRSAQRGRKLSLSDVNWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGZ5</accession>
    <name>A0A2T6ZGZ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1157002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000277">
        <property type="protein sequence ID" value="PUU74726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGZ5"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="391" mass="42071" checksum="E09B6BFB9C6B9919" modified="2018-07-18" version="1">MGAELSTQVDADTPPETLSRRDLPAVAEFILGGKCQKIVFLCGAGISTSAGIPDFRTPGTGLYSNLQTLNLPHPEAVFDISFFRTNPQPFYTLAKSLRPGQFTPTVTHAFISLIAKKNLLHKCFTQNVDTLERTAGVPPEMLVEAHGSFAGQSCIDCHAAYPADKMKEYLLAGSVPHCEACTGLVKPDIVFFGESLPREFHMGLSSVEEADLVVVMGSSLKVYPFAALPGRARAGAVRVLINNESAGGLGVRKLAKELGWAEELEEVWKSVGGGSDKKVGTEAESSEDAEPVESIDAKVGRLTEEVERGLSVVDGWKENVMKDLSIQETRINRMVEADLRGENGEISLVDQKNLGVAATDQPTSSSENRTSLNTTVKEPEHQVKKVDGAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHN5</accession>
    <name>A0A2T6ZHN5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_996954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000260">
        <property type="protein sequence ID" value="PUU74924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHN5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHN5"/>
    <dbReference type="OrthoDB" id="5323643at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015775180" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="16981" checksum="17235251BBF1B32F" modified="2018-07-18" version="1">MQAKVFLSYLLAAILALGVIATPVDVEGTPPANANTLFENVASFVGTPGPRHTEPTITPKEGDVLAASTSVVARDLERLEKRTLGCVTVSPYLYSSNCAGELRACWFPNGQCVNLNPFWRGKIGCFRPDPDTFCKLFTGPNCSGIGSVVITYPGYRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIH0</accession>
    <name>A0A2T6ZIH0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1031268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIH0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIH0"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="435" mass="47833" checksum="248F08AF853A1534" modified="2018-07-18" version="1">MASKAASPGAAILRQSRLFAMPKPLPPPLSYRLGHQEPAPYPTVQAITAPTASRVRGNWGLKRDVPHKITHTTMRVTELDTIERFMTFESANDDVLTLKKWHEIDLPLVKSPTLVGELMAATRPIDSVFDDNLSAGEGYKWKYLGPFLLDMPADEFKRYVLKKVKPRQKEFEAFVEKHMAGARGVYESAATADGETRKVKVNMDELRADTMKFLGLVADFLDIPRSGRPYRTHPSAGLHYTRSAAHIPYDPEHGPRPSRSVPGRSLNSGPPNPVVGVGGVAAVLRENNNYLGNNRTHGDRRQVRDYEPRSAYISTRGRIMMDVKPAVSYEEGMRGEGPGTIWGSGDAGSVRDQLMGLVPGQGRRLDGWGTWGTDSEKQQGDGKGDGKGGGGGLSKLHAPRPRFSETFTKPGQAKENGKRDNREAIDDILASLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIM7</accession>
    <name>A0A2T6ZIM7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1031102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIM7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIM7"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="6">
        <location>
            <begin position="268"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="391" mass="43729" checksum="075047759D7E33AD" modified="2018-07-18" version="1">MPVRIPCIWIPHPRLGRRYCSLAAAPPRPPPIGIANISGPRQIIEIHGRDAAKFLQGLTTRDIPMLSDSRGAYSAFLNAQGKVLYDVFIYPTNHNHRWRTQVEAKNFQPIGRPPIKKGPAVDDPGFFIECDVRSADALLSHIRRYKLSSKFDSRIIPRGEWDMWTIWDDHRLLLPDPNEIGCTDTRAPNLGKRVAVFGGRKLGVEVDFTVYNVRRILLGVPEGQDEILNGGNIAQESNMDYMGGVDFRKGCYVGQELTIRTHHTGVVRKRVLPIQLYRSGDPAPERLTYDPNLNLAPLLHGKDPNISNLSGKRRPAGKFLRGVGNIGLALCRLEVMTNLEVGGKREDKTVPEFKLDAEGDELRVKAFVPGWHMLGNATAFRRAPITASEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIS7</accession>
    <name>A0A2T6ZIS7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_954042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000234">
        <property type="protein sequence ID" value="PUU75400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIS7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIS7"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="9923" checksum="F890948909E032FE" modified="2018-07-18" version="1" fragment="single">NVQLAITENQQFSQLKPNSPCNAGQISCIQGDLAQCVGGKFLTTACAGGSQCFSLPLVNKVGTSVTCTTAEDAARRMNAGSVQELQALIGGISPVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ07</accession>
    <name>A0A2T6ZJ07_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1090286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ07"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015642268" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="94" mass="10497" checksum="499CF6F79ED7A38D" modified="2018-07-18" version="1">MIGTVTLCCATLLSQFPPSIANPLPVDKPEGSSLPTFAVSWRQPKPAPTISTSKLVDEQKSYVQFCLLLLHSDPNSCEERIYRVDFILERCNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ92</accession>
    <name>A0A2T6ZJ92_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_993998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ92"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ92"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="7691" checksum="D4D81EF05C912660" modified="2018-07-18" version="1">MDAEWDLMKPFVPMVGKEGHLSVAAVLMLTGFFLTGLFSINKSVTTAPLLAIPASLALGFGSVYLICAVGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJH2</accession>
    <name>A0A2T6ZJH2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1152860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000220">
        <property type="protein sequence ID" value="PUU75640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJH2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJH2"/>
    <dbReference type="OrthoDB" id="4507955at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="94" mass="10290" checksum="A827E32FD3F7655B" modified="2018-07-18" version="1" fragment="single">ATGYLTNPYATSECTEFPYSVADEYLRAMDIPIGEKWKYFGAFGAMAMMNGCCCTFSSTLCGSVGRRLVWSRCLGGLDSALIFGGWVVTKVMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJN6</accession>
    <name>A0A2T6ZJN6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_993721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000221">
        <property type="protein sequence ID" value="PUU75624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJN6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJN6"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="54" mass="5837" checksum="3A8F69B6930EDF89" modified="2018-07-18" version="1" fragment="single">KSDKLKPPSSINVPHILCENHSKMETALERLTNREKFGVAAGELSEDKASKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJZ9</accession>
    <name>A0A2T6ZJZ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1102708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJZ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJZ9"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="119"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="563" mass="63029" checksum="0B4B06665AC465DE" modified="2018-07-18" version="1">MSSKKKRLDFSSTPLRIAFPILSSFPGCPNVKIGGSGDSLMGYVSSLCLRFLHSTSLSIPAYKLSMGPRPWVLVHRGHYIMDSYGTITIVSRSVASTDAIQPCQDTTERKLLAKIDLRLIPVLTILYILAFLDRVNISNAAIFGLREDLNLGGVEYNTALTIFFIPYILFEIPSNILMKKFRPHLWLSLCMFMFGLVTCLQGFVQSYGGLLATRFFLGIFEAGIFPGCFYLIAMWYKREEAQKRCTFFFSSTTLAGAFGGLLASAIGKMDGMQGFKGWRWIFILEGVLTCTLSFFFYFHITDFPEEASFLTEDEVEFVKARLLADVGHSGREKDLEIKDILDVFKDYKIFMGGLMYIGLVMPGYGYAYFSPAILKDLGYSAIQTQLHSVPPWVCAFAFAMAIATISDHLKHRFAFAMFPLFLAFSGFSILLAVHDNTKVQYAALFLAAMGCYSAMPVIACWFNLNLGGHRRRAVGTAWQIGFGNIGGIIATYSFISKDAPRYSKGHAISLGFICLSALSCVAYYIAITTENRKRDNGQSKYSSATEEERKMLGDLHPEYRYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK97</accession>
    <name>A0A2T6ZK97_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">B9Z19DRAFT_992554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK97"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK97"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU75911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="639" mass="72461" checksum="9C3D8C03D31B6546" modified="2018-07-18" version="1">MYPEIDPVYDSDDTDVDETNTIGNIPLEFYDEYPHIGYDINGKKIMRPAKGAALDALLDSIEVPKGWTGMTDRNTGGDLMLTQEELEMVRKIQMGEVPVDGYDPYAPMVEYFTSKTEVMPLSAAPEPKRRFIPSKHEAKRVMKIVKAIREGRIVPNKPKQEEPQFYDIWADDAPPRPDHIMNIPAPKLPPPTHDESYNPPEEYLPTKTEKKAWEELDPEDRDKDYLPRKHSALRLVPGYDGFVRERFERCLDLYLAPRVRRTKLNIDPESLLPKLPSPQELKPFPTTTATIYRGHEGKIRALSIDPSGVWLATGGDDGTVRIWEILTGREVWKVKLGEDESVNTVKWRPGREAGILAAAAGDDVYLIVPPIFDHETEATSKEVLSVGWGYAEIVKKDPLKKEPPAKWSKPSDKLVDAGVVAIVTVRISVKHIAWHRRGDYFATVSPQGQNRAVAIHQLSKHQSQSPFRKSKGIIQRVEFHPFRPVLFVATQRYIRTYDLTKQELVKTLQPGSRWISSFDVHSGGDNLIVGSYDKRLLWHDLDLSTKPYRTLRYHQKAIRSVKYHHGGLPLFCSASDDGTVQVFHGKVFGDLMENALIVPLKVLRGHAVKQALGVLDVEWHPKECWLFSAGADGTARLWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKZ7</accession>
    <name>A0A2T6ZKZ7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">GAF domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_991453</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZKZ7"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="401"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="777"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1193"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1066"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1349"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="952"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1356"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU76169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1377" mass="152558" checksum="4167AF9A4255DFA8" modified="2018-07-18" version="1">MGDKQAENVDDPLEIDTFSESRDEQAPFSPSPTHQRPSSESLPFYFHHRGLITPGSSAAGTGSGGDFGPPPPDGRDIVYPIRSVVSISRPPPGLGSPAPGVRSGDAREELSETRSESQSRSQKTLTIANPDRKSPIASPVGGKRESGNSSGIPTSRQSLLPSTTKEGSDERYVTARFKHLVTNEGHMVVTGVSGSGSIQRCEDEPIHIPGAVQGFGVLIALKEDMEGRLGVKIVSENSEQIIGYSPAALFALESFCNILSEEQIENLHEHLDFVRDYASDPVHSGPDVFPLAVTSPNSTEVKLWCAIHIAEKNPDLLICEFELEDDHIYPLFSPTEEETPSLPEDTLNSSPSEQDLLESTLSASRPLRVLRNARKRRGQAAAMEVFSLMSQIQEQLSSASTLDVFLKVLVGIVKELTGFHRVMIYRFDEVWNGQVVTELVDPRATKDLYKGLHFPASDIPKQARDLYLLNKVRLLYDRDQATARLVCKSKEYLDDPLDMTHSYLRAMSPIHIKYLRNMAVRASTSISLTAFDELWGLISCHSYGQKGMRVSFPIRKMCRLIGETASRSIERLSYASRLQARKLINTVPTEQNPSGYIVASSDDLLKIFNADFGLLSIREETKVLGQLEYSQESLAMLEYLRERKFTSVLTSQNLSVDFPDLNYDPGFSIIAGLLLVPLSVGGQDFIVFFRKGQLWKVNWAGNPYEKNVKKGTQEYLEPRKSFKIWSETVVGKSRDWTEEQVETAAVLCLIYGKFIEVWRQKEAALQTSQLTRLLLANASHEVRTPLNAIINYLEIALESPLDSETRDNLMRSHSASKSLIYVINDLLDLTRTEAGQSLIMEEAFDLSETIRDATERYKSGAERKNITFEVVEYEGLPRFVKGDQARLRQAVSNIAGNAVKHTSEGGVRVDIWMSQVADGRCQIEIVVQDTGVGMSSEKLEALFREFEQVHTEEDVMDRPEARENESPPLSFNAVSKIPGQKILGLGLAVVARIVRNMNGQLRLKSEWGKGSRFTISFPLSLASEAELDSEQKKRVVERQKSPSPQPPSVTPAPGEILLIDSQNCRPQDMTRRNSGASMNNSGSLGGAKSGESETDEFVHTTSSPHLSTVSNSPPVRRGADIRAKSFLDTMGLATPQQRPNREIREGSAAPIKGPRAPDESSSPTPPPAADTAPMKIPPIADTNLPIEPSEKYEILVAEDDPINSKIIKKRLEKMGHGVALTVNGEECADLYTKHGQKYDIVLMDMQMPIMDGGTSTTRIRQFEGTDLGRCVPRRHRINLRVPIFAVSASLAEERRTEYADLGFDGWILKPIDFKRLKLLLDGIRDPAIRAKSAYEPGHWEKGGWFFGTPGEIKSSPPEHEDIPPAALKTKDEGPDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL11</accession>
    <name>A0A2T6ZL11_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1052510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL11"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL11"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF29">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE-43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="386" mass="43136" checksum="DF8E731964B827F9" modified="2018-07-18" version="1">MDTAQSDLVEWYKLETEFFQDHVRHARYVKEKNTHKKVKEDWSNCGELGTGGFGVVYKQVLGTTGRYRAVKTIDKKRLPPKLDYYRELLIMAILAKVCHPLLFVEFLGWFDKPETLYIAMEYLPEGDLTKHIGSPLPQATVQTISKQILEGLKVMHQKGIAHRDLKPANIFVVSTSPFRVKLGDFGISKRIRPQDTTTFHTQVSTRIYGAPEVLGLDSNNEASDYTNSVDIWSLGCVLYELLAGAPLFASDFQLSRYLFGKGPSPEDTLKGLPTPTDDAGISLLKSMLTIEPEDRPTAVGALGNAWFAGLKSDDEDCEDDQDEMTQSGNEGTYNKESEGKLTTRDLPRPQWGSDLTARKPEVGATMTIQGAEEKTDPQYSTIMSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL78</accession>
    <name>A0A2T6ZL78_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1088696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000195">
        <property type="protein sequence ID" value="PUU76245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL78"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11243" checksum="4387620646966B72" modified="2018-07-18" version="1">MGQLRSDGTGSRNGPGLRQTGRVLGLTRRMVCLREIWGITGGKEIQYRAPGVCSVSFSFLFLFFFSPFPSPFPSFLFSFSIPPLFSFFTFSLPIVFIFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLN3</accession>
    <name>A0A2T6ZLN3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_255895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLN3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLN3"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52034" checksum="8EA1D12B6777D9CF" modified="2018-07-18" version="1">MDEFRSLCEVPTLGDTSSKYQQIQANLAKLSLLLDTTPDLLTSEELQTYLTTILHPPRSLLPDEQYFQEEDDSKDEPTRDQAAWHPFHRASEKALMLLCSSLSHEPSPSAERLNVAIAAITYTNLADPWTNPTSYHLSATIQSSNQELTSTKTLIAILTTTIKPLFKSSLTPAGRPPQRESTNKGAALQTPTWPRELPQAITLLSYITTHLSTDALEGAWPLLIPPLLSIHDSTNPEHKISASNLLSVLLPKLPDGLLVRTGLAPVLRDALMPDLLLLPPLTPTRCSIPLLQATYKVLRTLARISTKDNRPRAEQLDAIFRNGIVRGFTFAGENARIAEELMRQISALVVDMGVYAVRHLGDLVQIFGTVLGDPFVALAQGLLVATLDAVEAVMGVCWVRVCGYVPEMLKAITSCYGTVCGDEGKGEVEVVDRLKKIASILRAVMATEKREVEMAELEENIAQADGRLVGLFDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMG3</accession>
    <name>A0A2T6ZMG3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMG3"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="139" mass="15334" checksum="988583DEA84BC930" modified="2018-07-18" version="1">MSSLLNQIMLPYGYTDEAGMTGAILIFPLSNQDSRPGYRPMLSCSDNCPRNAHASGTLHNNCSSRCHQFLTAILEWAVEQTHPAPPESTNVHFGIRVIMTMWKSLIFEAVVTCVVALLTLMLGHGTNRRIEIDNAGTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMX9</accession>
    <name>A0A2T6ZMX9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000174">
        <property type="protein sequence ID" value="PUU76806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMX9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMX9"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="261" mass="29176" checksum="4E9AC69367FE9751" modified="2018-07-18" version="1">MFHRIVNAIETGSPELLVFDGVDVKHFTAVRKRLRRHASEMEGHSFRIHFFSGEKVLKIVIPSMMHECVGGWINATLTRASRHGIIPDAWDDTMLVMSAPEYDNFAGEFCGSVKEADITFVPRVGPYFNQLAEYPTVVLESGCAESSERLTEDARMWQIGSNMGVRVVLQAKFFPADHNYGVRFVFLVSRANPKGGSCLPDYYEIFPPPANPYHNPSISFEEFYGGNCPPGIDPKTKVELDLARLAEVAAIMIRQLGHIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN00</accession>
    <name>A0A2T6ZN00_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_223029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN00"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN00"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="93"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="404" mass="45162" checksum="55BEE1E96D542C0F" modified="2018-07-18" version="1">MPDASRPQTADGEPDLRTAGFLPHLDPLRQAATEHHHSRIYYNAFPNAFTPSIPTSPPSYNDISLPPARFRISPREEEGKEQLPAYSCSLHREAIFEQKMELSSPFDRAGVRKWAKVYAVLHGTLLKLHKPKRISFFASGTPKKVDRREDSRSSSSNNEIVGQRPAGYYPGKLIGCYTLQLAEVGVAADYKKRHFVIRLRAQTEQFLLSAKRVEVFLDWLEALSASVDLSLSLEERSLPRYQTLPRRRRRRRQPHPPTAGSITATTATAATATVLATQAPLSPHSSTASQSIIEVDLHCILTSPQTSTPTPTTRPAPTTTTPPNKQAQMPSGKWSPPRILTAEANIRYARRCMAVLCGDSPRQSNYVVQDGKRYKIVWEKREMVLDEKICASLPRYEDVVVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN04</accession>
    <name>A0A2T6ZN04_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1087583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000175">
        <property type="protein sequence ID" value="PUU76794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN04"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN04"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="251" mass="27862" checksum="B7FC99B746C00B20" modified="2018-07-18" version="1">MRASSEGHPNLVSNSVTIPKKRNVRHLVPYCPTPLLPPPNTNLSSTENQLLYNGSTVSPLTELVLPNFLPAISRRHTLSHPWIASFYPHILLLAIRPPPVFTHQSLTFPTAVDVVAMLDAREVCSGEIGRKGGHIKPNSGELFLKLVAIFGREKARKVTEFRMGILDKMIAIADAEGVEAVDVYFDAESWATAKSCLGIYLEEFSKEIRKWETYEGEEVSLQGVRYYIDWMGGSTPLINRISGIITISSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN37</accession>
    <name>A0A2T6ZN37_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_219544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN37"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46333" checksum="253289AABC5E6921" modified="2018-07-18" version="1">MPATDDPEQEIIIAVMGVTGKSYCIREISGISDIIVSGRLHSCTDEVQPYSFPYAGIKITLVDTPGFNNTTKSDTEVLRGICAWMSANYRKGKLLSGIIYLHRLTDVRTDGSSVKYVKMIQKLCGQNALKNVLLTTTRWSDVDQVQGERREGELRDGDFWGGLIAEGAAVARFTGTRESGLELLDKLTGNKPIPLDIQDQMVEKKIDYAQTNVGKFMNEELDSLHKKYQKELKDLKKQHQKAIAQKDDLLKEVLAEQRAQFRRMLEEATAQKKFLENLSVDMMRKLEEAEKKREEERQREDRAVIAVASKDVSIGEHLTSLLTSYSTIGRLIYDIDDATEFEKQPFEVEIRDQSILSPITVLVKAGQEFFSAGMSRSNYIIYNQGYYQYKPSSSIKRGTQNFIIFSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNU4</accession>
    <name>A0A2T6ZNU4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1128792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNU4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNU4"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="80"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="715" mass="79380" checksum="F6C47834D689A439" modified="2018-07-18" version="1">MGNSLSSRCRDHQQHAKSNSHKTTRCTHGYSNQNTENTSNSDSSTTNVRTNKESWRIQEWLSPLEPYGRHEDVNNRRLDGIGDWVLQKDEFKAWCKSRNCSVNPTLLCYGGQGVGKTYMSSLVIDTLSEQARRKGVVVLFFYCDDRAQKDQSAVSIIGSLLRQFVLGETRIPAGIRSAFEESRQETRQECGSGLQLPDMVRLFVKTITSIERAYICIDAADELLPQDRSGFLDALGQIIREAPNTRLFLTGRPHIRREIEKHLIQGASSINVVVDQGGIARHLSRKMDDNARDADLMKDLKNDIMEGMSEKASEKSPLIALKMDDILGGMSEEALEKSPSIALGTDDALGGILEKVSEKSLPVALEINDILGEIRLARQRKMLQKVTTIGVNLDSVYGETLQQIKEQKGGWPRLGMGVLMWVSSAVRPLRIDELCHALAVEVEATDLDPQKIRSQDTVLGSCLGLAFVDKKTSTVQLIHDTLQEYLSRPGILSGAHKILGETCLAYLNYNQVKELSASNVGDLRHMPFLEYSSLYWGDHAKIELSDRAKTLALELLSQLENHVSFTFFSKGKWPVNYPNSRRRFTSLHCASYLGIDAVVAVLIEMKSCDINQEDPFSNTPLMWAVTRENHGAVKLLLTCDGVDPDKSGSSGALTPLLYATSCGDVEMVRLLTQGGANPHKAGDNGQTPLMIAARYQDMKKLALLRPRAISISDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP74</accession>
    <name>A0A2T6ZP74_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_987361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP74"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="248" mass="27558" checksum="856DC9C7A17FD51D" modified="2018-07-18" version="1">MASRNNSVSTTTSYATNASSSTVATSISARSSEDRNTILSDFNPTVVLYIPPRGSLPSSRNTIPIHDLTPYIKVLDRENLTKKQLRTLHATKPWEKDGQDGEQGLVSRRMGLGSGRSVLGESIEWRVPWDVMKPAKIKGGEEELDVWCGKEDRRAQLFDVGSARYVWRFNEGSDQVLLEKHMTDTRSRHYIGAFYIKTTPFPALGPLTSIGGTLILDERGLDKLTAVASVLILLKRERQRRRIGGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPL2</accession>
    <name>A0A2T6ZPL2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GPN-loop GTPase</fullName>
            <ecNumber evidence="7">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_987208</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPL2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPL2"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000579">
        <property type="entry name" value="GPN-loop GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="396" mass="43540" checksum="6D496D328E8FD8E2" modified="2018-07-18" version="1">MASSAPIGESSQQGSSSSAPEPSPRASRDGPPPAIICIGMAGSGKTTFMQRLNAHLHTQKQPPYIINLDPAVKTVPFARNIDIRDSVNYKEVMKQYNLGPNGGIMTCLNLFATKVDQVIGILEKRASSINSILVDTPGQIECFVWSASGSIITDAIASGFPTVIAYLIDTPRTKAPATFMSNMLYACSILYKTKLPMVLVFNKTDAQDADFAKEWMTDFEAFQKALQDEEGNEDGLGGSGYMASLLNSMSLMLDEFYKHLDLVAVSAMTGVGIDDFMKAVEGKCLEYERDYKPEMEKARKRREEQKLEEKEKELGRLMKDIDVGGGGKGKEEPAVVSDVESSDEEAGQGVLERDEDEEMQDEEGLQEKYERVGKENELGTDPLLDASLKRYLHANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ15</accession>
    <name>A0A2T6ZQ15_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1050046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ15"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ15"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="136"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="316" mass="35471" checksum="81F96DCDE49ABF6F" modified="2018-07-18" version="1">MASKHYSNLDLINLVDSFPNAATHPVFHAERLGELSILVHDAHTLGYILPSVTAVLKDTKLSGTHWGFSGKVITLAGETVEERSENIRKTTESWRENGIFDVLRGWRNELYTVYSPKGHEYFRLERSACALFGVVTYGASVHMTAYTASPLKIWVPRRNPEKPTYGGLLDNTVAGGISSGTSVFETLVRESEEEASFPENLIREKARAVGHVSYFYQRMKTAGGEEGLFQPEVQYVYDLEVGNNVIPKPCDDEVQDFKLMDVGQVKAELAKGSFKPNCSLVLLDFFIRHGIITPENEPDYIEIGSRLHRLLEFPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQH5</accession>
    <name>A0A2T6ZQH5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_985788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQH5"/>
    <dbReference type="OrthoDB" id="5393198at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="37913" checksum="C9857BDDA7B817C5" modified="2018-07-18" version="1">MDFFHRGNRRFTGDSDSKNSYRSFRSMRTVYSRMVSPTGSACNLRNSPSVDSPTTLRTPSGGSSVSPPPSPLCPHISSEGVCEKCADTAAACERWISAVEETGSTHEQELPESEPMPETLLVTAYEGQSSPLSGEREERSPIGLGIEMPSAIYEEQSSSLARPPSPPLTPPPAPKRRKERPAPVVTTYNPQRRILWGLEKNCDTASATITLSSKHTGATFAPAPVQNVSKGRSTLEGFREMSCTLEHCGIHRGDWNLTATMIGSKRDSGATLAASMHSGSEDRPECKQHPEEVYCTPKHYERCQVGAENRLELTENKRRVPRIVDGLVTALTKGISWLREKGWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQS6</accession>
    <name>A0A2T6ZQS6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQS6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="22252" checksum="BA1EF4E0961B7910" modified="2018-07-18" version="1">MAITIILSPPLERGTLPASYSSSSSTCLSDIKGWRDSTSDSLLYTGVPRTSKVAYFLKLDGTFPAEEIPGRSQYFIPAPRVVPRPGIIEFKAGCANGFKYGGKGREGGREVKERNGDDHAIVFQFLGMKVDWGDDVRAGMEVFEKEKEDGVWSPVGWLTAGIHDGWLGATDLSCSTFNRVIECAPMLLDDILYFIASKVQAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQW5</accession>
    <name>A0A2T6ZQW5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1049498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000137">
        <property type="protein sequence ID" value="PUU77872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQW5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQW5"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="290" mass="32852" checksum="81815671D7283EF3" modified="2018-07-18" version="1">MKGPELWAVKRIPRALPNFTFKRYEAEVKNLRALAGHEWFVCLNSTYEDTHYMYIAMEYIPMGDMSQSFTNGYQWNEGDTKVVIKQLLHGLAVMHKEGITHRDLKPENIFLYLPENQTNVLRVKIGDFGTSKRIPPSNTSTYLKTTTGTQSYMAPEVHDTSKPKTNRVDIWSLGCVLYRMCTGNLLFKDANEVLKYFWTASSSPLALDNIGFSIPCVSFLRDILQPAPKDRSSAEDCLKNAWIMSEVLEPDYSIGEALYTRLSNISHRAPDVHSFPDIVANLAVESGSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR63</accession>
    <name>A0A2T6ZR63_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1127458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR63"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR63"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="66"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="466" mass="52800" checksum="F55D92C50D1F45E3" modified="2018-07-18" version="1">MSNFQEKLLRWTPTISPGRNGYDRAGGEKRESKYSSTELLTPDSEFTQARSDSFSSVWSPVWYTGWHAGVLTCAISAVIVLFTNVGLTIYAATNPECKMERGVGTLYEGRCDKSRTLGLWLHLWINTLSTLLLSGSNYTQQCLAAPTRREIDAAHARRRWMDIGVPNVRNLFKIKPERTLLYNSAVYTSLAANDFLVTAVTKDYFEPGAYSNITEAFPQHLYRELYNSSTGATVYVDDGNSRGSYDKQLFNSVLEEYDTSTRSYEDLTPSECTKIYNTDFVSNHRNLYLITNHASNTTHSNTLLDMIHVQVKDHVPSPSSWMCNYNEVGLRQIYEPTKPSCNPTELTSNVARGLPWRVELTTWEEVEIGGCKSERTAEKCKVQFSLGIMIVVICCNLVKACCMVMAVVRSREPTLVTLGDAVDSFLEIPDPTTMGICFADRQFIEREWRCGWRTGPRQWKQKGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRB5</accession>
    <name>A0A2T6ZRB5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1085052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000131">
        <property type="protein sequence ID" value="PUU78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRB5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRB5"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="80"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="177"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="278"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="378" mass="41301" checksum="9B47B006E39EEF00" modified="2018-07-18" version="1">MSGLVTPTYATLSAVFPSTPFSVAVPQKTPRLQPSVASLYPYASISEEAKKLGKEAQEEFRHASEATQKKAGKIDMYSPKFYAACTLGGVLACGLTHTAVTPLDLVKCRRQVDSKLYRSNIQAWRTISSAEGIRGIFTGWSPTFFGYCVQGGIKYGGYEFFKKFYSDLAGPEKAARYKTAIYLAGSASAEFIADIMLCPFESVKVRMQTTIPPEFKGTTEGLKSVVAKEGLNGLYKGLYPLWGRQIPYTMMKFASFETTVEMIYNYLPKSKDQYGTGVQTTVSFAGGYIAGILCAIVSHPADVMVSKLNANRLPGEAFGASMKRIYGEIGFVGLWNGLPVRIVMIGTLTGLQWLLYDSFKLFVGLPTTGGLAPEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRX2</accession>
    <name>A0A2T6ZRX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1084574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRX2"/>
    <dbReference type="OrthoDB" id="5153521at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="123" mass="13953" checksum="746D9598DEE445D8" modified="2018-07-18" version="1" fragment="single">MPRLDSRNCHCNGCRSWYARNQNKRKAAEKLHWDDEICTARQYPLSPSAEERGDLWDDSSSDSGSIEGVAYSFDRRGPSAGTDTLSYAVTEAVKKFENKELATLIKNEYEVVDSSDSDEDFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS29</accession>
    <name>A0A2T6ZS29_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1065184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZS29"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="51"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="858"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1548"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="668"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="929"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1060"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1154"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1408"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1619"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1556"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1575"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU78273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1727" mass="191745" checksum="57DB5082FBF6E6D6" modified="2018-07-18" version="1">MVGTPTSPASPSFNGTRPMSAVIRPARSSSRLSMSSKAGGSRASDEDTKTSVKVAVRVRPPLRSTDPGFDLIPQRFQRGMVHVTSPTSLAVDSPQGRKIFVFDRVFGQEVDQNGVWDYLEESVNAFVQGYNVSLLAYGQSGAGKSYTMGTSGPDEQSNIKVMGVIPRAAAALFERLGSGAPNSRNSSSGLRAPARYSTPVSQLIKPAVDKGWTMKASYVEIYNEQLRDLLLPEGTRPDERVPITIREDTKGRILLTGLHQVTVNTVDDLLGALNFGSSIRQTDATAINAKSSRSHAVFSLNLVQRKPKGPPSKDEKRFSMPTEMLGQEGYVTVDSKMHFVDLAGSERLKNTLAQGDRAKEGISINAGLASLGKVISQLSSRQAGSHVSYRDSKLTRLLQDSLGGNAITYMIACVTPAEFHLSETLNTVQYAQRARAIQSKPRIQQVSDDGDMKALVERLRAEIAFLRDQLKNHSESSSGASSGGQTRSERSSDKEREMELQNQLLDLQENYGALSQRHAKLISEITKVRDTQELSAQPNDYTDSAEDRLARSNSLSVAVEQVVLEYEKTIQSLEASLSSTRGLLSANECCLLEKETKLAYIETVNQQLHARVQKLMDRESSTENYLHDLETKLDSHTSGEEKNTAIIAELRKEIARIRENEAGCEDYISTLEERLAEADQDMELMQREIDRLEHVVDRQRSLGKLDNLLYELDSMKAQKEEKLADKVIEVPEKVRNGRARPHSDDTLVEVPESVNGDDFVSPNEGTPGSATSETGDHISQPAPVKVIPSITLDNSPQIEYPLQSPAQSQFVADKLESVQQELIDLKVEHEATINNYDQMSANYEAALRDIAALQDRLDEARHQAAPSQGTSPPPSPNLRPTSFLVGSRVSDLKAEDQDSSSFSLSSELSLVGDSPISPVSIDSEAQRIKEELEMQRKISQEREEALARELETVKVQMEEALKAQEEEHDLLHLQLKQSLDQLSEFRHRERVSNVISPSGTHILRRKSSQSLAVLDRARRSFDNLHRIAVENFKDDPDILENFELNIDAALKELTTRSDRISELETEITSLRKDMDAKSAIINGLARERSSISTSPMDISVVAVMERRIEETQAELNSTRELLAIRESDLAIAHRELSTQSGESTSDVEELLIELTKEKTLNAEKSQRISDLQREIVDTRQSHDATLETINRSKKALATTVQELETELARSKEVVEAERALKVAVQEEKIQHQERVEMLQKIVTENKATIDSQLARVAELEKTHAATREQIHNQLSQTSNASESAIEEVRKQELSAKELEQTIAQHREVIEDQQSRLTKLEASYQDAIDQVEALQRKEEAAVLALKEAEARASEEIATTNAKHEELLQTSRAKLEESKSAILEHVANLTKLQAAHAEAKSLIGTLEGDKSKALEEAARHAAAVKALETEMEGSKATVKKHLDTISELQELHKQTDKEIEKLSEKEAQHAKLLEDLEQQLTFTFDQNQENATKLANITAEYEHLQQEKKALITESTAKNTESQQLIESLTDEVASLQTKLAEVQMELQGLGGARAQRSNSTSSNSNLRKSTSTGSLPSPPPAIPLPPLPGNATSPVAGSSPPPPTPSMSRRPSKDYAVAHMEDQEARIKTLEKQLQAEKALTITLEEALTDCENKMKSLRSDRDSFQTKASQVQQELDRARNESQTSRYSIQAVEEERLARKKAELAREQLEVRMRDIAKKNKRSFACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS54</accession>
    <name>A0A2T6ZS54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000123">
        <property type="protein sequence ID" value="PUU78318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS54"/>
    <dbReference type="OrthoDB" id="5498262at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="27569" checksum="C4BDFDCE488F67E6" modified="2018-07-18" version="1">MPYLRSENGKREIADRLHSRFNKRLVCPECNFESFTHGAFNKDSGGTPDERRRLYRRFKCHSSSGCHKTVGVTELLDMCQKLSSASSLNHRGSFSPRERAKRQSSSEEQNPVSISESSRIIDRSVNTSKIAKNPPIITISSAAESVCSIKETDYSFNIESELAATEFPLRAKDLLALQRGLRETIKLFKLLETKISTLDTIVERLQAGKPPIELPSLRQDQPKDYDNLAYPNLEEIEEQILNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSQ0</accession>
    <name>A0A2T6ZSQ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_66469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSQ0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="19631" checksum="4AA7757788726E4C" modified="2018-07-18" version="1">MGLLNFPDELLLLVAENLQDAHDLSSLLKTNTRLAFTLSSLLCKLAAAPEYATTALYYAAANGDADMVQNILEKGATVELAGYKDVNLDGEKTGDEGEKCSKDMVDFVVKKGADLVLDTGTNGSGEFRAINWAAWTGNVAMTKFLVSRGAGYRSPPPFSRRGHRCYQFRWPNSSQFCSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT02</accession>
    <name>A0A2T6ZT02_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma interferon inducible lysosomal thiol reductase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1114840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000113">
        <property type="protein sequence ID" value="PUU78622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT02"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT02"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="28239" checksum="922786950CE97F21" modified="2018-07-18" version="1">MDLIEAYWGILTLAYYLNPWGVGKQQSWGAPSLTTEIKVPLEIHIMSKCPDAKDCLEQLIAPALEEIESLVDFRMSFIGRIITDDDISCMHGPSECLGDILHLCAAKINTPPSPPPAHTYLPFSLCLTHDYKNIPDREFVEGCAGKSGIDFRKLSECASDVGPDGGLGIFRESVERSKMLGAETSCTVRVDGKKRCIRDGGEWKDCDGGSDPEDLVRDIKEIYKEKNGHREGLGEKGKTLREWIESERIIWAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT05</accession>
    <name>A0A2T6ZT05_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1048159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT05"/>
    <dbReference type="OrthoDB" id="5426707at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12139" checksum="31D0B8D79A4D5E4C" modified="2018-07-18" version="1">MAYNTRSSAHTTRSKTKTPHKATTTATTLKTNRTKTPKSAPTTKKTPSHRTGAGVAKKPRHKRKPHISDKLEGALLKVEGTLTGRRGVKAAGTKKIRGTDGKGEKRSVRRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU74</accession>
    <name>A0A2T6ZU74_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_957017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU74"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="14035" checksum="D695F48329B46CF1" modified="2018-07-18" version="1" fragment="single">EATVRVLLAHEGTCVNQRDSNRLGMTPIACAASRGNEAMVRLLLEDERVLTSLKDYQGNTVLHIAEDITRMLLLHAKTDVNFAGRAGPTPLHGAILAQQEPILQLLLDHPDIDPNPTDKYGRTPLHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUC4</accession>
    <name>A0A2T6ZUC4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1101049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUC4"/>
    <dbReference type="OrthoDB" id="2288358at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="159"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="159"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="691" mass="73043" checksum="8770563298F64789" modified="2018-07-18" version="1">MSPKPEPLDTSSSAVQREHHPISHSSIQSLPIPAASNSRFGASLPALQDPRYSATSSSGYDSSSPASAASSIAYSPFTNVFQPTSYPTSASSTTFPSYSMSSDSRPRIPSIQSPTSGMGPHHRSSSGSTKSVSPSLGSSVRADYATSTPHLSRHLPSRGSQSDILASPHSPLTPASRALDSPTITVSPTVGSTLASPLPGQHDPTSNGLGGVNSAGPPLGETQLIHSLTSADGHHVRPEIHARVDKGFFLSERDWTCYRRNYFSVICSYSLQPTTYSLPLYLRRTAGGPTEHVLAFAMCISAVVDAPGGKVVDLVQHTPKRDKGPQHKPNRIKLSPQPTGGMAFAASSSSPVLQQQVHSPQAGPLDREYSFPQQAQQQQHIAVFDRIQFKSATANNGKRRAAQQYYHLIVELYADVGSPSSSATSVSGHPSNPQGSDGGWVKIAYRISAPMVVRGRSPGHYADERRTSASSPGAGGGSGNGNGTHPSPTSGGSGFMSPDGVTPASGLGGSSSSMGMTGLQLHTTGISSMHSSPATSSIHNPSVSSASSSSHLEPPIDPILDAETASQLNSEFVGYQYFPSTIYESTTQPPSQNLENNYETHSYSNDRKSEHPLETNCQQFDSDVSSYIPASMSSNDSLRKTVKEEYGANWLGGGASVGREQRFNTTSLYPKCGRFEPAETSRGYYPNLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUD1</accession>
    <name>A0A2T6ZUD1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_980462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUD1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUD1"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU79107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="31538" checksum="3D6E22A78FE891A4" modified="2018-07-18" version="1">MDSTLPSPNPASSISPSTSLYDSILASMFAPPPTVLIATILAIFFVPIFIHFIVFRSRSSISLPTFLLVGPAASGKTSLMTSVKTGQPPAETRTSQAPLSLECSIPASIAGTSKYRSVNDPSLKAHKKFLLLDTPGHGKLRHIALTRISSPAIRGVIFVLDSSLTDVRAVAGYLYDVLLTLQNSATSSTTTQPKKLLVACNKSDAFTALPPSKIQKLLEDEITKIRVSRSKGILDVEDDGEGNDEKEWLGEGGEGPFTFQSMEEVGVEIEFKGGSVENGEWRDRLSPWIGECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUE6</accession>
    <name>A0A2T6ZUE6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1024076</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUE6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUE6"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU79111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19655" checksum="67E2DF593498BF35" modified="2018-07-18" version="1">MATSAGRTALKINWAQITTSLGLKGQTVASLQAFKKRNEDVRRKVAILSEAPQEVDFSHYRAILKNQAVVAEIEKAYSSFKPTTYDLNKQLKTIETFETEAIKNAEATKGRVDMELQELEKTLKNIEEARPFEDLTVDDVAKAGPDIDIRTTEMVSKGRWMPAGYKEKFGELSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUS6</accession>
    <name>A0A2T6ZUS6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone deacetylase domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1100943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUS6"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="701"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="800" mass="86581" checksum="A4653C07005C13BB" modified="2018-07-18" version="1">MSAPATVIFHDTSYRHRYSRPNTSLQDLTTIVERPERIPAATLGVASAQTRVGRRKLSIRKSERMGSLSDPEVMLVHCHAATAKGAKSPWPQELAAMCGAAAEKLKKGECEVPKGYHQGDLYLGEGSKEDLEGCLGALYDGVDLVFGENDRNDTISEDGHKHGGVRRAFVCIRPPGHHCAEAQPSGFCWLNNVHIAIAHAARAHGLSHAVILDFDLHHGDGSQAIAWTLNELAESTQNPSKRTSGIQVPNIGYFSLHDINSYPCEYGDIDKIKNASLNLNAHGQSSYSTQEEFWTLYKEKYSSLLTKAREFLSAASVSKPKKGREFKAGVFLEHEGAGMQRHAVNVPTSFFARFTSDAVALAEEYCHGRVLSVLEGGYSDRALTTGVASTYVSPSIGLTLSGQDRGWDAGWWGMERILELEGHFAKMTAKKPIVERASTSYLSPTAASVAKKSDVPRRVMSNGYLDVIPWEVAAFDLSRMIIPEYQESAEIPPIEKPARRSGRHSVAGDVIPESTRMTLRDRKPKPSADTSPDVDRGRRRRTTTSGIIPDSAVTSRAPSRAVSRAPSRAPSRAPSRAPSRAQTVGPPSRGVTSIPPSRGATPASGSRQIESTSGGGVTVAGPRKTVAKKPSIIGTDNSRRVVDQHPTAAVQKAGSTVSSASSVVSSSPTGSQEPMKPNSDDGVDSLTKGMGKFKLTYKNRDKDRAEQLRILEQEKERAERALEAEKQRLAANDALKRKDGGVNRMKEAFEGNRAGNPAVGSHAEKETKMVDNAEISIAGPPKDQTFHGGDIKFADPWQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUV9</accession>
    <name>A0A2T6ZUV9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_980343</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUV9"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="30"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU79235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12945" checksum="0955D9EE63C742F8" modified="2018-07-18" version="1">MAELLNKPRSELTEYEIAELEKYEFSAGPLSILQTAVRSHNQVLISCRNNRKLLARVKAFDRHCNMVLENVKEMWTEIPRKADGKKGRPVNKDRFISKMFLRGDSVILVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUX8</accession>
    <name>A0A2T6ZUX8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_980022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUX8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUX8"/>
    <dbReference type="OrthoDB" id="5424234at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="480" mass="51636" checksum="F67418B836AA8BB3" modified="2018-07-18" version="1">MKPIGGIVTNKKSIPDSFRQVETFTTEYLSKLWKIYTVNRDVLDKGRRLENLFWRIWGSEQIQRTFSGRTVSRIFLMIHEGEGPFEKTRFRIPPLPMPTPPHPSDPESTPRPSSEIECPPTPPPSPIPPVTSIAGSQLGSSYLSKIPSEMAITASLHQAFPLRPLSPPPPSQTTSSAAGQLVDSAPPQHNSPGPSRLAVPSNSKAIASTDTAGSKPSSLASSENESVSSKEGGLGKNPAKEKKARTERPAKGRRKAGVSTRVTATRRSRPVGPRRKSSSSSNTAVNTAFSSPSRTLTGDIARSLPSDSVRQQHKASSTDGGDSESDATGKRGNTADNNWIVEPDFRTKYLERKRKEKLVALTSVAFVAPLVVKAVPTVAVAESQATASTKVSRGKGKGVVLVDQIVPLKGLPEEAADSQAARTLVANVRDEDIDELPTTLVRRKSELTLMFEAEAKKSGEKIGKGSLGKEKVIIEGEMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW22</accession>
    <name>A0A2T6ZW22_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1100691</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW22"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW22"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="99"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="166"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="269"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="441"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="553"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="649" mass="70183" checksum="D8450A7F1AB85CCC" modified="2018-07-18" version="1">MSTTGGNYRGNPRTAPPGRGATPSFPPTPSGSGVPVPAPSPGGPSHSEAGSSVSDSRKRQSKRDEAIRRKVENDLNKKKHTVSRARQTRKVAPGTVMALRPSQALQIKPNTTVAEAAQIMAAKREDCVLVTDDEDRISGIFTAKDLAFRVVGAGVDARDVTIAQIMTKNPLCARTDTSATDALDLMVRKGFRHLPVMDENQDISGILDITKCFYEAMEKLERAYASSRKLYDALEGVQSELGSSQPQQIIHYVEALRQKMSGPDLQSVLDGNPPTVVSVRTTVKDAAAMMKENHTTAVLVQDNGSITGIFTSKDVVLRVIAAGLDPANCSVVRVMTPHPDFAPMDMSIQAALRKMHDGHYLNLPVMNEAAEIVGMVDVLKLTYATLEQINSMGTTDSEGPAWNKFWMSLDNDTESAVSDGTRHTGPPIRPHQPDSPVRVLFSLLTLHLTTAIPRLLLYGRMHRCQVAASGGLIELLTAVVQKLGSEVQNVGGEPEFGADGKLEKQGFAMSYVDNEGDIVSITSDRDLIDAIEMARSGGRDKVDLYVHDPDSPAVIATADPKPVADTPTESIVHSRRRRRHEEEDVEESSEEEEETTAHRKAKKNAVSHFPTTAPVPPEIIPGVPNELLLPGALVTLAVVIVGVFAMSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWF6</accession>
    <name>A0A2T6ZWF6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWF6"/>
    <dbReference type="OrthoDB" id="5278911at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="26842" checksum="A256F1091BB5D27B" modified="2018-07-18" version="1">MTKGAPIPQELHIVILTLHSIAHMQWDEISTQLKVHSESARWIIQRSKDRVGNEFFALLNDVGHDEPIYPAGPSQKYPEGSNESEQLKEVALNPENFGQNPVQLARLAYLDVFPSTAYRYIHQHHNFAPYKPRQFTLMLSGHFAHGYRGEPYIWVKETLKEQDEHEQELQEENLQKQKHQEEMCANARTLGTEEYKILEAINADIRNYNENRLPNEPRRMPRCPEWVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWZ8</accession>
    <name>A0A2T6ZWZ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000075">
        <property type="protein sequence ID" value="PUU80012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWZ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWZ8"/>
    <dbReference type="OrthoDB" id="5340163at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="758" mass="88358" checksum="E8BE422F054AED31" modified="2018-07-18" version="1">MNRTAPNPILEGKEQYHHYIPRFVLRAFAAQPQPKYDEPTRPVRKKKKQRKRKPTKETAGDAEGPKGVEDDSPDEAGPSNATKEPEPRVEMGVIKDTGKPKPRKPRFDPSMDPYMKFYDLESGVLDYAKVGRSYGIPDMYKDVDHERAYHVEELLSKLESDAARIYHRIKNDHESGKYNFSVTRKDLNLLRKFLFVMRYRRPGFWSKYTGTIDTYEHNDRDMLVEFLKERSITDLRQVWLMGLEVIVRTEIDADGEWLQTIGREMFGGDADMYVFHMRESYMAFCQPQSSGDEFIITDNGFGIFEGPVVWDPANLKSTGADGTAPRLGDPVYTEFHKLAPLSPRLILVLRSNYLRDEPIWEKRRKKLNQLEPRRNSDSVLQDLPIKPPKVHYWLLPKKSKPVYTLEDEFFFEIYKVKTEQVHVINTIMLQEAVRSITWVSDESLVRSLPAFLENPKFMPAVSLAVFPEFEPFMALRFQKERLLSLWDKPYPTEGMRPLEKLSNINESMKNVRYLQPYYKLGGAPELFPYDFHQADLLMQFRSFIADHCGPSIPWRNKVNKATIKFMSNFPPRIVWFHIKMWKLKANVIQKGLQLSLVTEGDFDILQESGPEDLIANLVDFLPFPLLSRLMLETTLKEMVRLERKEKLTAQRASEKELEFGMMSEEMYLMNQFGGFGGSWSLVGTPHHFEPVDFCDPFRPDIPPNLLSKFYLQDLNLRSKLRGRVENMILGTRGTPEVYGWLSQLLWDHLYQIPPNFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX09</accession>
    <name>A0A2T6ZX09_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000075">
        <property type="protein sequence ID" value="PUU80009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX09"/>
    <dbReference type="OrthoDB" id="10573109at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="410" mass="44432" checksum="DF4CD439CB5A37E5" modified="2018-07-18" version="1">MLLGDIATKYNAALTRLLAEAQRVPTVAAPVTAPLVAPIAIRNNEYANMPSLSLAGPRSICLWLDKGSVRHPNNPVLPGFNKIQWQTQRHVYWMETTEPTIDNLFKCKNKVLSRGYTYYLLVGMTRQDLLLYGLRVRDHDGISSTGAIHLDTSDNRGPSPNALSDPVESDRDGNEPRPYAPATKRATGLSTKTAGNTMRMTGQSLHSGLAEINQPEPDSNDSAYRCHISYNRVMPDLESGFTPCPGKQPSAPPTDLRIRTLKSGRQIGRETVLKKASQLSSQMVVNSYGKSDLAVMTEDKEPNSSADTTEPSRNVACGEPVIDSSIEGKPDGLHGEINQSRQPTTRPCPPNTPPPLCSNPSDDLASTASEQRQVRTSAGHVLMLASGAQQPADTVVTLANPPSRCRSLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYC8</accession>
    <name>A0A2T6ZYC8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial inner-membrane-bound regulator-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_974822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYC8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYC8"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032741">
        <property type="entry name" value="Sls1_KH-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048748">
        <property type="entry name" value="SLS1_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14611">
        <property type="entry name" value="KH_SLS1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20777">
        <property type="entry name" value="KH_SLS1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="184"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="873" mass="98755" checksum="6464E1FFC165A330" modified="2018-07-18" version="1">MLPAFYTSNLAARLCRQFRRPLRNLRIPPAYTRCFDSFPRQSLEGKEKGSSEIGLEPPSELIILRTLTPPKPRHEGLRLVEEPVEDGETIEKTLDKLLECEAIDAQIIDIALMHPATLEVSQERYDQLAQQLWKSFLKPQLFEYYRTQNSNGRTPRKLHFTATKSEIIDAILSVKWGVAVSSDIPEKLDVLVNKDFQGTRRDMFFILGKDGRTMRRLSEDFQARVKVNTKSGKINVYASLENYERLQKAIQDLLKGVKENEFDMSWAERLCQFNEQFITPIARITGTYIEKKDDKTLLISALDPGSLQDARRLLLMSFDLQLRSSHSLLYSAPKGKKVPKGALYPAHEKSALPWNFRGVEWGRWRNIKTHIEHSGGLQENSSAILKGTLQRRVQGATQDTNITAAEFREMLDHDDLRVPEQHRSELSTEYEAILGHLLHENSDPPPDQCLTTQKFVKSKHRPQVFLTDAPGLAYITQTLSPVGSPPSTSEEAFHTSKVQASAGERRTPDQTCIVKFLPSPWEYLEGFNRYPPLELRFKVDPKSGRVGQPTLKAIHSSTIADAMFPSQECDVRFRRQKSISLGILDDPANPRPEYGVAQSELISYISQSRLNPLSDNELKASQILHVKLPEWMISPPERPGSEDEREERSPLTTVKYFSTSLEYRREFAFDWNGMELYQTVVQGGITGGKRSEFRLCWNDREGVDSLAKAPRITELEDCDKVVDQAKPSPEAMAQIVAVPDTEATDGIPGEPILNLEDVDESGDETTEATTDQPLRDTPQGPHPSQNPRFSFADFLTNTTELVEWLGKFLASKEWRFTTQLKEDRAVQSGTSGTEWRSRGGRGTSRGRGGRGGRGGRGRRYTGAAGSNWGWYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYH5</accession>
    <name>A0A2T6ZYH5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_974597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYH5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYH5"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="660" mass="73134" checksum="04D39F5B9A12C651" modified="2018-07-18" version="1">MLHGMVKVPGYPVAEEEISGTTFEFWSSLAEFLLDPENVAESDIPSLMAAGKKEIMQAIEEFWTKIQIPPHSESLKWTKDLKDGFTSFRKDVADLVEVAYGILGLELFDRLISQVISALANSQTGGNVPWEQIEASLFCLNSLSDCLGDEPDEDESLKVLFRSRLFTILADFGNQIPLKVRQTAVHMIGSYAVFFERWANFLPTVLNFLFVAISTPALARNASKSISSLCSSCRSTLTNELSVFLYQYELFSATPTADDIAKERVLCAISYIIQALPSENQKLDSVNRILGFVDKDAQQVLTLLHQHPEAAKELGVSTLQCLVAIGKGLQAPDDIPIILAGEGGGQMPPPFWEQERGLAIQRRILHIIQTLVGSLTEDGEVIDAACAIFRTGFAETTPGPFVFPPRVVTEFLLERANRGVRVETVLSTASTMVSSHSLDGSPDISTEVGFFLELILGLVERLQNPQEDPEMSQGLVEFLNRLFSRYIAVIVCYQPRERIEMLLWFVMNAMQVRETLVKKAACTFWASLVSFAADDRPEIQASINSFVHMCGPALAEKLIWGIGGGASRSEVDSLTEPLKKMIARQVKAKTWLSASLSRDGFPSPNLSEKDKTVFLNKIMTLRGKRGTNQIAKEFWLSSRGSDFACEYHMPSQLPLVPCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYI5</accession>
    <name>A0A2T6ZYI5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_722519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYI5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYI5"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="13990" checksum="A62B03D376E7C32F" modified="2018-07-18" version="1">MEAPVNQPMSDAPQENSTQEPDSQTVEQCITYLSCKDDTSRFVGLAMLSSFLTHIQDINVLVRCWKSLNPRFLDRLLKSGKCHSRLCWALRGVNKRGLRRDGMKQAELVRNLRRKQKIWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYQ3</accession>
    <name>A0A2T6ZYQ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NlpC/P60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_974397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYQ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYQ3"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051794">
        <property type="entry name" value="PG_Endopeptidase_C40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359:SF3">
        <property type="entry name" value="NLP_P60 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47359">
        <property type="entry name" value="PEPTIDOGLYCAN DL-ENDOPEPTIDASE CWLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="113"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="269" mass="28090" checksum="7A7AE11D59B0D081" modified="2018-07-18" version="1">MAAAAGASPMDQIFERAVGDKCSAPEGSGTCKSTSACNGISYPQPLCPHDPDDIQCCVEIPCTVSGSNGFCRSVSNNGCSGGTFHPGTGAPWPCPGSDDIQCCIKSTQNPPSGDVGAKILAKALTAAGTPYAWGGGSCNGPSKDQPPYQYGETGYDCSGLLCWAVCQVTGRDLFKAGLRVTNSMYCASDATLSAHGMQKVDYAQRRAGDAVFFGNACNCAQRSTIHHVGIMMDSGTRMWNAPNDQINKVLESNIATFGEKPCPKVVRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYU6</accession>
    <name>A0A2T6ZYU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_974244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYU6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYU6"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="40064" checksum="37B5846B4374CC67" modified="2018-07-18" version="1">MVFPPPPTDSIDWSNIGFRVREVNGHIQSTYSIHTKEWTTPTFIRSPILPIHGMAPGLNYGQQCYEGLKAFRSASSNSIHLFRPLSNAKRLAHSAGFVSMPAPPTELFLKAVEMAVSLNAEFVPPAESGASMYIRPLLFGSSAQLGLSPPEEYMFVVFVLPVGVYHGVKPVDCLILEDFDRAAPKGTGSAKVGGNYAPVLRHSDAAREEGFGITLHLDSQTRTHIDEFSTSGFIGVLPNKTLVIPQSDNIIESVTSDSVQRIAKDLFGWDVQTRKVKESELEDFVEVFAAGTAAALVPIKSITKKSTDWKKIYGGEEPGEAFVALLDGLKGIQSGRDKDPFGWRSPVREFKPSEATGQEVQAVDQMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ13</accession>
    <name>A0A2T6ZZ13_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ13"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ13"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="356" mass="40525" checksum="9B6802BA47A4C6BE" modified="2018-07-18" version="1">MSQSEENIDTAATDHPELSPLEAASSQDDSDEDYFSNDVSETTSLNSSILDYEYENGRRYHRYRQGSYLMPNDETEQDRLDMMHHIYLMMLDGKLHLAPIGDNPQKILDIGTGTGIWAIDIANEYPSAEVIGTDLSPIQPQWFVSPWKEEQTLKMVPPNCRFEVDDAASPWTFTKNSFDFIHSRHLSGALSDWREYLKQVYSTLKPGGWMQLSEYATDVTSDDNSYPKECAIRTYLHLMNSAANKIGRVMNVAHTLKGLAEEVGFTNASQTLCKLPWAPWPSDPKMKELGKFALLNCETSFEAFGLALLTRVIGMDGDEALKLCQDSRKELRNKRIHIYNLHYVIIAQKPLEEEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A086</accession>
    <name>A0A2T7A086_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A086"/>
    <dbReference type="OrthoDB" id="10412008at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="8354" checksum="889D1A4155D196A1" modified="2018-07-18" version="1">MSAQSPKVKSAEGNSVEEERKSRIAGFESHARSMGIIGEEAIAQKVAIWEGIWAAKQSGNEFEYGAGILLDTATNADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0E7</accession>
    <name>A0A2T7A0E7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1776-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1020254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0E7"/>
    <dbReference type="STRING" id="42251.A0A2T7A0E7"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48219" checksum="B5DDC3C1B578E6AD" modified="2018-07-18" version="1">MSGEPTDSINEFFYSLKTYSFIVADAIDKQADSLAGTIRDTLSKSEWIPESARPTPKRVPVPERMLNAVGAGRGDGWWNRNKWTFVMIAVGVVAVVGATGAKKVGNGGRREVVVIAGGSPHDPISRSLALDLERRGFIVYVVVNSIEDEHVVANEGRSDIKPLNIDILDTENAQTAVEKFATYLSTPVQAFPGAHPHNLNLAGVILVPDLTYPTGPVETTPIDLWSNTLNLKILSTVVTAKSFLRVLCDFHSRLLLLTPNVISPLSPPFHAPETVAVAALGGLVTSLRRELAPLGVDVCHFKLGTFDCSAMIARQQQDRINATRAEILSWAAPARIAYARNYIALSQKSGNSGPAGIKGSSLRELHLAVFDALTDEKPRRIWRVGCGSLIYEVLGKVMPDGLVSWMLGSTRKNGNGGRKEEGMIMGLGGVGSASGSAGTSEGSVEWEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0K1</accession>
    <name>A0A2T7A0K1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0K1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="183" mass="21995" checksum="9B86BF551BB1A251" modified="2018-07-18" version="1">MPFRSCQNPLRIIKCEFWTRCVTSTSNILEYRKYRIIHKEGTGIPTRQALQKGKREKRRKRKKKRKEKRKEKKKGKKKQSKERKKCNSIRRYHRSGMVPATLIRSDIDGHFNSRRQQQHLQIEFIKPHPSVKAFSIGDRNTPAEWFSFWSSSWGYRSPPSLYRNGEEEKVRFVWGKKKKKSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A121</accession>
    <name>A0A2T7A121_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A121"/>
    <dbReference type="STRING" id="42251.A0A2T7A121"/>
    <dbReference type="OrthoDB" id="5407894at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="842"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="953" mass="100613" checksum="A1B26EC0EEC9C98D" modified="2018-07-18" version="1">MTDSTSRSRPQSSSGPGSRSRSTSRCPKLTTSSSYPCIPLLSSRAATSSPPAVTSAVAFGSTSATSASPSPIPWIHSAETIEDDSPRTPGSILERPYSGFPWGLHFKEQPVILDSWTQTPTGEPTSAKAKSSVLPHPPLPHTRSDPTHTAVRTKRTPSRASPKSSLKLKLPPPPRMADGYGLALSGEQQDNRAESEGIFIAQENHRPRPSLLGVAFPTTPDTSVNSMPVICAGVREGKRAGHIDFRGGMGPNHEVIGAGGATAALLAANPHLAPGGLAPLTPPDDNGVLEWRGEGMSELLVPVIPTARAKDPSCAAVCDNEDTKPALPRRAPTGGRIEVLKSPEETERTARMTSGDSAGTTETRRETIDEKEDASADKSEDNSDNENTGHEDIVEEGWLKGAMASLFDCALSVQMTTEAVRMLSYTLPCPLPTSSTDSATPTPIPSNLGSNPDRLPASAAAAPAVAAAAGQQFSPAITARCHSRAQAGSGSSTPNGLIGADDGITTALHTLTKNIQRRCSNDGTKRVYIHVSHAISPGIPLNRLPSTPPAGGYVGSPGGFFGGGFDISPSGCVGGGGGYFAPTVFNSIVVAPESVPTAPSMSFHRTPTIPPPNPILPPFSLHMTLLERYIPPTSNAEDLSMFSTQSSVILDRLHELSPHGGSLLFIYPTKTGAKHFDKQYLGPVLDPLLRKLMVLYMLREDLLWGIRNMAAIERMNEFEGLRWKLDNFCARFSNAINDNSMWGKSGTGSQASGLQLDSSYPKTRVRLVHSQKAMIQLNDNSWREWWSQQEQLRIREAVKRHFSSLQPPAEAQTPASPGASGPHGSHHAKSASMSSPKLGSPPSMAQAAKATTASSTPSSPTASSSPQSQYSFGYGAPGDLAREVLDGVRAPAVRPSSRGMSEAVVASALAGPGTFGVGGVVGDYEISSVPGDRRVKERGIEVGVFVLRREIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A129</accession>
    <name>A0A2T7A129_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A129"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="8959" checksum="B059976C30A41A13" modified="2018-07-18" version="1">MSWHVKRKLCIPSERSWMREGDKGGGGGGGTIIYSVITVLLLELDSIPVSVGLMDVLCNFFHLPACLVAVSVGGWVAVVPEMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1L3</accession>
    <name>A0A2T7A1L3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1076790</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1L3"/>
    <dbReference type="STRING" id="42251.A0A2T7A1L3"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="175"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="275" mass="30869" checksum="57908C00F3193372" modified="2018-07-18" version="1">MNNTLRANLSGPSIRWILSKPIISSSAPSRCSFLAAPRIELRRRYHSYQHPAPAPPFTTAELAILSASLLHVPSHGFSDAALSFGARDAGYLDISVNMLSRGVFDLVHYHLATERLRLSDKIDFRKPENELPECLRNLSIPAKIRVLCMERLKANVPIIHRWQEALAVMSLAGNIPASMSELAKLSDEIWFLAGDESHDTTWYTKRATLSTVYASTELFMTQDNSKDFEATWEFLDRRLNDVKTIGSAVSNIASYLDFTVHAFANVLRSKNAPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1V7</accession>
    <name>A0A2T7A1V7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1121852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1V7"/>
    <dbReference type="STRING" id="42251.A0A2T7A1V7"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="271" mass="30049" checksum="21FDAA26B194047A" modified="2018-07-18" version="1">MLLKSSWGSSFTYNLQTMFAKLSVLVFYRRVLGNHGWFRLGVDVTIGFVVLLGIASELVLFVNCRPLRYSWDKTIPDGYCWDIVLWYYINAGMNIALDVVITGLPLSPLFQLQISKRQKIALCGIFSLGGLVCAIGVFRVFQLPALHNSKDISWDLTNAMIWYFVEAALIVIAASGPALRPFFHCYMPTLIGRSRGNHGGSASYGIGESHDMQRSQISTNVSAGGGTGYGKGDSIINEESGIRKTTELAWKVENIPRPQDGENGRWESWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2N2</accession>
    <name>A0A2T7A2N2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1075965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU82003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2N2"/>
    <dbReference type="STRING" id="42251.A0A2T7A2N2"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="172"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU82003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="268" mass="29982" checksum="D172FB6C0C2C793A" modified="2018-07-18" version="1">MPYTNPTMVISDNEFPPVQGGGSLLLAWQVRNRKVLVIGGGNVAAGRILNLLNADAKVTVITPSIGLHPEVHHRILKRQVTHIDRNFRPSDLEDPDITMVLTAIDDPQTSTQIYTLCKQKRIPVNVADVPPECDFYFGSVHRDGPLQVMVSTNGNGPKLANIVRKQIAETLPTNLGEAIVKVGSLRKKLRKVASASSEGPKRMEWMTRVCETWSLEELCDMDEDDMENLLSHYAENKVMTYKELRGIPPPSEEREVFEEAFDGSFGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2V4</accession>
    <name>A0A2T7A2V4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2V4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="59" mass="6227" checksum="443952A43D6DF9DE" modified="2018-07-18" version="1">MGMGAASVIEDPTFRSKKLDDKKVHAAEALGSKDVGVRAKPGFTKKVKEANGLVEEGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A311</accession>
    <name>A0A2T7A311_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1018535</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A311"/>
    <dbReference type="STRING" id="42251.A0A2T7A311"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="274"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="508" mass="56931" checksum="B1C496741BF60466" modified="2018-07-18" version="1">MVVLAASICTRGGKAVLSRQFREMPRSRIEGLLASFPKLTDTGTQHTTIETENVRYVYQLLDELYLVLITNKQSNILQDIDSLHLFAQVVSSICKSLDEREILKHSFELLSAFDEVVCLGYRENLGLQQVKAFLEMESQEEKIQEIISRNKEFEATEERKRKAKQLDLQRKEMSRNPTGMGSTGRSGGSHSSHFPTYTPPPKPAVTDSYDTYEKKKTFSSAPKGKGMQLGRKSKTTEMFDQVRNELSSEAEERAPLVQAQEAVASPRQSFSGDKKAIQVIISEQISAELSRDGGMKSFEVKGDLQLKILDQTLSKVKLDISANTSDAQFRTHPNVDKALFNGQSVIQLKDQSRGFPQNQQIGVLRWRTTTGEAPLSFTIWVNLDSSHGKYNVTVEYELSSDDTLRDVVVSIPFRRDEPSVTSMDEVYEVSGDSIDWTLPSVSEDNATGSFEFEAEADSEGEFFPMTVKFRKEKPIVPVDVDGVTLLEVGEGVDFSKEIKVVADNYVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3D1</accession>
    <name>A0A2T7A3D1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1121127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3D1"/>
    <dbReference type="STRING" id="42251.A0A2T7A3D1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphoinositide phospholipase C"/>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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    </dbReference>
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        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
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        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="10">
        <location>
            <begin position="343"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="9">
        <location>
            <begin position="462"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="603" mass="67032" checksum="7805E5A4BB019496" modified="2018-07-18" version="1">MATATTSDYAAGGGTTTQALAAKPNKINSKIILGELQKIYTSLCPRGCSTLPVSAFKSYLSGTQRVAIHDAPSGGEEVKETRVQKWVHKVFGHASQAASAEKLLSDDQDITFDEFVSYHATPANSALALPDPRKDWSRPLNEYFISSSHNTYLTGHQLYGSSTTEGYINVLRRGCRCIEIDVWDGDDGEPEVFHGYTLTKEISFKDVCKAVAKHAFSEGGSLWQGDAGEGPVIISLECHAGPEQQEKIVKIMREQWGDMLVQGIDPEDVESLPSPLELRRKILVKAKYLPPPPKVTPIDPTVPRVPPPAVADSSSDSSDSELEELAKKAHKQKPPKTKVTRTLAELGIYCSSHHFPSHAAQPFTDEPTSKIPNHVYSFSEKVFANLHAQHAESIFHHNKDYLMRVYPFGLRFSSSNADPTEFWHRGVQLVALNWQKCDEGMMLNEGMFAGEGGYVLKPESYRPGGIGIHEERRNLDLTIEAIAAANIPLPEKSDSPKRFEPYVKIEVHTETGTGLKKKTKAKRGIECTWNEKLEFKGIAGVIEKLTFVRFKIHDEEFGRDDLAAWACIRLDRLQEGYRFVNLINNEGDPSDGLILVKISKRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3T0</accession>
    <name>A0A2T7A3T0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TATA element modulatory factor 1 TATA binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1105813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3T0"/>
    <dbReference type="STRING" id="42251.A0A2T7A3T0"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="3">
        <location>
            <begin position="233"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="348" mass="39012" checksum="DFB7AEABCBFCA1EB" modified="2018-07-18" version="1">MDLEISQSKINDLEGELTSSKKQLGKFKKEHAEEISALNLGFSKERENWQKELQTRLEEERTKWIEASRAFSPPPQAPLLPPASAHSTKKFSGSLSTSESYFLGSNNNNHRKNSRSPGPLETPITPEGLGLTSLPAGQLPPPPSRRGFSTPPLPIRQDSLPIHNSSPRSSLQNIATTQLTTDPEQEDLDPVPVDFYETSINPTTTTSFTGPYIYQTPTSPYPQSLARHPDMISVSTVAAGPSVQLVERMSSTIRRLESELAAIREEMETAQAQRDDARREVVDMVREVEGSREAEKRVKELESEVEELKRREEYTLEMLGEKSELVDELRQDVLDLKGLYRDLVSTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A423</accession>
    <name>A0A2T7A423_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cortical protein marker for cell polarity-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1120530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A423"/>
    <dbReference type="STRING" id="42251.A0A2T7A423"/>
    <dbReference type="OrthoDB" id="2503993at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015413474" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="4">
        <location>
            <begin position="233"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="5">
        <location>
            <begin position="385"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="3">
        <location>
            <begin position="920"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1253" mass="133069" checksum="BF202C5CBE732FF5" modified="2018-07-18" version="1">MRSPSLLAPTSWLSRRLWGILSLSAVLASALNVTAVSQPSFNLDGLGQVALAGDFNAISIYEFSGQTEAPSLSNGSQSLLSQLPNGIFAPLASADNAILALCVHQLKDGTVKGIFVGGNFTSLGNVPVRGLALFNPQDGNVTALDGLNGKVQALLCDKETNTVYVGGDFVGAGSSNSSNNAIAWVDGPGWTDLPFNGFDQPVKTITKSPNNTIVFGGTFNNLVNASSPRVRYAQTINLVSADVTAEQTTTLSGFNDPAAIVCTIGKEKQWLLRDGQRGSWTANFKLSFRPTKLRLRNANFQGRGTKVFRFTAFPMNGIMNLTYTDPATNTSANCDAWCPLSATAEFQDFFFVNEVGMNSIRLDILEFYGAGGGLAGIELFQDDIYSFAVPDLNEPSCGSVPAKSNSTFIGPWFKTQGLQADSEYLSTNLTPAQSQSGTVSVVFEPHIQQSGEYVVLMYTPGCRQDASCSARGQVNVTGTYTKTGGSQSAPPYYQTNDFDKYDTVYRGWVDAVDDTFRPMVTLTPAAGQTAPIVNIVAQKVQFQMLSNSTRNGTSEDGSDSSSLELNGLYEFDPKQTDAPKASDVAKSVISTAGSRLRTGAKVKAVVSKDDTIYVAGEFSAKDGSFQHIFTIGPSGVTPVAKGGLDAPVNSLLLQGDLLYVGGQFQNTNSSPTTGLGFVASYNTKTKEWSGLGAGVDGRVRELVYISLNLTRGTRDGIAVSGDFTTIKADSANTSAMNVEGFAVWIPSEKQWLERMSNESISLEGTLSGSTNVPNGSILYSGSMASQTDAAPGAVSLRSKNGLDVQAFPIQLVGNQGAPANRKRTVVPSDFTGVVTGVFYLNNGKNYTILGGHFSAQGNDGTINNVAIIDNKSTNNSVIGIGSSLDASSLVFSMLIIDQFLFIGGSITGKVGDNVVGGVAMWDMSTMSFVGNEQPVGLQGVNGVEVHAITRRPNNKKEVYVAGKFDQAGSLPCPALCIYDHDAKQWEASTLDVSGQINTLYWADVNTLLVGGDMNINNTATYLAIYDARSRDWRAFEGDITNIPGPVTSIAVNANTINSIFISGTNANGGATYVMKLKSGKFQALTGLGDNTVIRNIQVLELQGGSNSNDFLDDNQVLLVMGSLNLPNFGNASAATFDGASWKPLFLTTTADNQPGTIVSLFSQKQQKFSSGGKKLAKGFVILISLAIALGLVFLLVCLGVLASYIRRRREGYVPMPTTPSPRGQSPDIQERLRPEHLFSNIGQNSGRNGAPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4F7</accession>
    <name>A0A2T7A4F7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4F7"/>
    <dbReference type="STRING" id="42251.A0A2T7A4F7"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="246" mass="27028" checksum="6CD182C77E3CF7F5" modified="2018-07-18" version="1">MVEVSRAISMDEGPIMEVPKKDRDANASAHGIEQRCSSPSLKGVVHLDEPDSEPFGKKFTLRLSSLIWLGGEKIFKVETLAEPSSVSWFDLTASFRLYKRKILETVISQTESKEIMVRARGLSYSVAEMLITFLTIFPVTAGLGETRSWSMLKGVQPLARGIHEKFVTPLPTEVNAGDEGVRTLYIPITPSPTPSKEVHIQISIPSAHTTLLASAIFYTPSQKTCTKAADACLTTGEITCGENRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4M4</accession>
    <name>A0A2T7A4M4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1074413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4M4"/>
    <dbReference type="OrthoDB" id="5336241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23079" checksum="C469C0B5B190FDD4" modified="2018-07-18" version="1">MAAPFIILPSELLLEILQSLPDFATLHALTLAHPRFNNIFHANPTTICSSIAKSDFAETYSLALSILPAPTSPREIGIEEAIELLHTRSTCQKLADAWGCSLLEALGFTDGYGAPVITQVQKRRIITAAYRFWRVVHDTSYIAELDDLAILEMTEFVGLLGELRMFEGMGDRVEVITAKNFLQNRAKQSGLKVCVVNLRLVREWFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4V7</accession>
    <name>A0A2T7A4V7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1190157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4V7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="31420" checksum="108F1B0050BB5F3F" modified="2018-07-18" version="1">MLYSLQYPSVMPSLCPSSNTQSAMLYYVESQPYSPKQELQEIEADPSGGYGFASNPQIPYDHLPIMFPGYSLAAYERPQNLAGNDDGSNFTEAGFSKEQHRSPATPPFYPKTDLDWSHEADVQSPYDFHEKETWGVPELSFYPQAAHEKQILGLPGLGLSFQGAADDESDTTSSGPSSPSTPGDCYPGVIVSQPQPFHEASYDSTNLGPYQSTPGSFSDTNYPQDNTLTTTDTTRKAIPPAPWETPFPLNCSPAHIPTSPQTAPPPIPTISHFAAVAVPNEETNEIPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5E8</accession>
    <name>A0A2T7A5E8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1119920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5E8"/>
    <dbReference type="STRING" id="42251.A0A2T7A5E8"/>
    <dbReference type="OrthoDB" id="3945378at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="413" mass="47444" checksum="20281AF7CF241E03" modified="2018-07-18" version="1">MAPKVDIDLNPGECRPLLDEPDLYGLGVRIGTYTQWLSTIIATCLMQDQKERVNMQNVNYIFAFAGWVALVNQTRSTWPADAVIVILLFMGTLTLHTMIEVFDRMRPRTVRRKDPNLGTAGEVVRTMLLSAFLIWVTWWWFEGIYHTSRDCGAYIFYYGGPVRVLGNFKLIGRIWSLLLLLMIIPVLEKFWFMIKRTRAHSRAQRGRPVDKHGPPINVWSWEFWTQVAAATQEETAELEKFHPPDIPNPQTKQRRGLYCALLLGIGVFILIIFLEIMLVYGNSDEINKISGVGDTVSMVTGCSNVLMILWKLKQQRVTEREKRRRLLGEYRYPKTFLYDAEFPLLQKIKHWLRITGSEHIPDGPPPPGQPQHEPGQPPHEPGQPPHEPGQPPHQPGQPQIQGQDIQEIHPHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5K3</accession>
    <name>A0A2T7A5K3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1098866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5K3"/>
    <dbReference type="STRING" id="42251.A0A2T7A5K3"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11404">
        <property type="entry name" value="bHLHzip_Mlx_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="279"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="353" mass="39494" checksum="ACEC5C8CDC73925A" modified="2018-07-18" version="1">MASSRSTFDFYGFEARFNASPPPAPVGPPLLDTHEQKGLENWFESIGSGSVPSSHLFDPELPDDSPYWSPEMPSNYQSTVPEMPPHHHHHQYLSGGMDGYLTSSSVSAAPMAAPSQIDINPFNTSRELLQRQQGQTPQQINNHNLLNFGTDTNFAPNGYHPPALPVPLEDKEVEVRSRVYAAFRNDSTVTTAVNSPTEIKYEQGGGDTEDDDSCTPVYDDNESTPSPSRNSAMLKRRMDGGEDYSKSARKPRSRKPEASMRMSKKKVGGQKRDNLTEAQKRENHIHSEQKRRNLIRQGFEDLCSLVPELSSGGYSKSAVLVHAANYLDDLKKGNDRLRLYLQHLQQLQMDRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6D9</accession>
    <name>A0A2T7A6D9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6D9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6484" checksum="3D48C1760FC20C2B" modified="2018-07-18" version="1">MPFQPCTVKNPIIPLASSLSPQDMYNSRKRMPLREAFLFPSLLHAFLVPLPKAMIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A754</accession>
    <name>A0A2T7A754_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A754"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015580899" evidence="1">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="118" mass="12434" checksum="CB329B3EDC69FEF4" modified="2018-07-18" version="1" fragment="single">MQFLKTLLVLLFATLISAAALPQDTDTDTDTAIDASFTGVRTEQSADGKQYTFSIYDDNGALEGTIVVTDDDSAQLDINAFDASGAKVDGDASDGVAGSSFRVALACNRACIIRKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7G1</accession>
    <name>A0A2T7A7G1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_962709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7G1"/>
    <dbReference type="STRING" id="42251.A0A2T7A7G1"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="689" mass="77558" checksum="9745961661186DD0" modified="2018-07-18" version="1">MPGPNSPHSTDPRDTLPQKPHPLEENTGGQENHGDWDYAPSREQHMPSTGSVSNREQSVKLTERVKAWLHNETQRQEDRRERKRSAKRAVHQALHMRCPPDELMGSGDIPAFSDSSSDEEAQNSLSQLEAILATARASSPAASTRRRSVLSRRGSSGRPRARSLMGNASDTDYSSDGEPVVPACEVYLKTIEEVGIDEFKRQVLTLAHTLKCKDWRKVPLDRFEDISIGRISGALTNTVSLSLLENCKSLGIFTNRESSLVKLLLRIYGPQVSHLIDRETELSILRRLARKRIGPRLLGTFENGRFEEFFDATTLTKDDIRVPETSRHIAKRLKELHEGIELEDRERKMGPVSWCNWYKWVPRTKQIMAHLDAAENLGEKGYICGCPWERFETAVERYKEWLYGKYGGEENVKGQMVFAHNDTQYGNIMRLQASGKSPLLIPSNEHRQLIVIDFEYASANTPGFELANHFCEWMPNYHDPVSPHFMHHTKFPTSQEQRNFLRAYVEHSLAPSFTTKSVSMTGESSEPSTPPTSYFSAKSSSSMPSFMLDARTPGASYKEEEASRQRGIVEEVDRLEGEAKVWRAASHAMWCAWGIMQAKIPTSEIEAMINGQPHGIGGPMSEETKGAAADSGDRGLKNEEGGEDEDEFDYLGYAQQRALLFWGDMLTLGIMTPEEVGEEVVGKAKVIAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7H1</accession>
    <name>A0A2T7A7H1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl transferase/acyl hydrolase/lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_782309</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7H1"/>
    <dbReference type="STRING" id="42251.A0A2T7A7H1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="305" mass="34417" checksum="D48710F385F94CDE" modified="2018-07-18" version="1">MLGRLRMDIDACIIKYQKMSGDIFKRPWQFPGKPIWDAYFKKPWFSEEKLKESIESVVELMISPQEKSLLESQGVKFSDAPMADPNIIPNVNTCNTFVCAVRIEDLTTALLRTYPQPTTSLPETCPIWAAGRATSAAPLFFPPMKLVTPPSPIPADFFDGAMKNNNPIAEVRDEVFLTHRVESPRCALSIGTGYLTKATGDHGFWTSLAMWATGGFGYLGWTLLQLATDTQAKHLEIMREGKYARFRENYVRLNVPGKLANIGIERWDKMEEMRHLTEAYLATEEARAEISRCVELLKAGRNFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7M0</accession>
    <name>A0A2T7A7M0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7M0"/>
    <dbReference type="OrthoDB" id="10567133at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="152" mass="16788" checksum="3ED8CDC845A59181" modified="2018-07-18" version="1">MATKIKLKEWWKVFGAFAQDKKIRSTAWIYKHQPLAAGLGTTVILVAHSQYGQSKNSKKIDALELRLKREMGDVGEKVTKEIRGDVNEVKKEVGDNVKEIQGAIIQYTRATLKAIEGDKGQLEEFFQKAGADWDPEGGFAGGFGGFKAQASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8A9</accession>
    <name>A0A2T7A8A9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_962053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8A9"/>
    <dbReference type="STRING" id="42251.A0A2T7A8A9"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="22646" checksum="F01C8F3850FF2FDB" modified="2018-07-18" version="1">MLTFEKVSDALLKLGYSHGGFLCDITSRTPLPQTPIIAPATTVQFATKSNTTFRPSPTCTVPPAGAHFADLIAPGHTVVITQEKYTSNALAGGLVVARMRKLGAPLVVVDGRVRDVPELKLPVYARGTSTVGAGAGSKVVGVGGEVVVAGGEEGEGVSVSEGDWVFADEQGVVVFPRGELEGVVELVRGIALADQKVMRDVLRGGELAEAFREHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8F1</accession>
    <name>A0A2T7A8F1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">VTC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1118536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU84004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8F1"/>
    <dbReference type="STRING" id="42251.A0A2T7A8F1"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU84004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="842" mass="95713" checksum="3979BDE442FA8343" modified="2018-07-18" version="1">MRFGKTLQASIHPPWRDHYIDYAKIKKLLREGDDSDSELTPVRRANQMEGWTENDESEFVHELVNVQLEKVNNFQREMNEQLKSRTAKCEARLEELVSATPAGGPRSSLSPAGGQVGDEERQKTLTQVLEDLDGITSDINELEKFSRVNFTGFLKAAKKHDRRSRGGSSAKGKGKGKGRGDASGEYKVRPLLQVRLSALEFNREDYSPLLYRLSAMYAFVRENIDRDANDHGQTRTSSVASGPQPHGSRKYISHKFWVHPDNILEVKTFVLRRLPVLIYNPQPSKEVQASRRDPTINSLYFDNTQFSLYHDKLSKAPEAASLRLRWYGRLSDKPDILLERKTMRDSDSEGAVEERITLKEKYVMDFINGNYSMEKTIQKMKDRPNNNGEDVNKYEALVQSLQDFIQEKKLEPMLRAVYTRTAFQIPGDGRVRVSLDTDLALIRDDCLDEDRPCRDPEEWHRKDIDDAEMEHPFSALRKGEISRFPYALLEIKVLESGLHGRSKEWVNDLMNSHLVKEAPRFSKFVHGISVLFDDHVSSFPFWLSELDTKDIRQDPKQAWEVEQQKVKKQIEDETIVGSFRPGSRDFGGRSAPFVNTPNRYGVTPPIAERGLPQIAPQGEDAKKSGPDEQSSDDNDSEEDDSDAEDLAEVSQSAATVSGLRNLFPTFSTSRYGRAHRKPNVPVKLPPGVQKPGILIMHSGPVQVEAKVWLANQRTFLKWQHISVLLASLSLGLYNAAGKHNYIAQWLAVVYTAIAVFAAVWGYTMYMWRSRLIRERSGKDFDNVLGPVVICLALAVALALNFTFQYRNMKEKKRHVHLPLTTAIPEIFNISANKELVAGLIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Q8</accession>
    <name>A0A2T7A8Q8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1098333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Q8"/>
    <dbReference type="STRING" id="42251.A0A2T7A8Q8"/>
    <dbReference type="OrthoDB" id="5366531at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="89980" checksum="FA58CD90AA22ABB0" modified="2018-07-18" version="1">MRNAILRLLPISRPQVSFSSLMTYTCTQCHRFRTSSSLSTPLRETAIPRELQALIHERTSTFDLLKEQADVADVSSLGTKLVDEPRLRGNFHLWWNLLGFKRRVYSDSGVKDVWKGLRIRSIDLPVRGSHATLIWQIFLKTGFQDEDFLEEVWEYIKDLDSRNWRWAGVYQLIVGHFLVIDASKARIWHKRLYPRHAPPFWPAFMRGALKQGVEAHIVLREIHAVIERPAGLYGSIIPFLCSMGLFTEAMKWHRHCISFDDLPGNTATADKLIEWTAKYGSLQEMSMLMLSFIQMGVRVKESSLIALIISRPKKLEALGFILAQANRVDRSVMGDRFWAVVLRQVQLGTSVIFRCMQAFGGGLNVGRRTVEALKKRMDYSREKALSLLAEFGMRVQGVEVVSNAEPSELVGRLVQQIGARGLAGMEELEFLLKESLDTRNWEMFDQALSLPSPGGPTAKVYDLVFQSQLRRGTLGDAINLLDHMRKSSISISSTSLRLLVKAILPPRKRAKNPNTMPGFTNDNLIDLIGILTSLLRSGLTNLEPALWRERRLSDLETLALGLVEWYHPARSEITRHRFSILKYDLPEALTSHPDLQSTPGIPPLNPLSPLRLLFPPQFIHAIIQWGFLTFRPYSQDLHKSIPPPPPPEFAPCVATFTWGIALARELKVLGVHIDTRSVLRAVRTRFAVLYNAPEANGRPVVLSGRRINHMAVALNHLSLAEMVDIIEKAWGSGLWRRVGWERGREGRGEWERNMKKEVLGTGIPRRVVWRLRRGARVRQRRRIMGAFLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8T8</accession>
    <name>A0A2T7A8T8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dfp1/Him1, central region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1118217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8T8"/>
    <dbReference type="STRING" id="42251.A0A2T7A8T8"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="581"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="535"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="638" mass="71564" checksum="0488707CE6A853A5" modified="2018-07-18" version="1">MSRRAPLTTLPNAVNSPYHSVTAAAAKRQRTQRDLSYAQSAATKDQIAEITARASARASNTESRIAPIRKRALGRSTAGGDPPTFNGVSHAQAQRRGAGRGTEQNNNIDSVRAWQRHYKKVFPEYVFYFENIPEDVAQKCQKQLSHLGARLELFFSNSVTHVVTTRAIPPEGATMAQAGSRSQAATINPSLLDGGVPKADFTFKAPTLSRKFSTSKLSQEDPRGTSRQAYCDILLKAREYRMKIWALEKFQRMMNVMFDVTSTTTTATQGRETSQATHVGAPNVDLTHVLRNERLHGPTDRDPNAAATDLVYFKGHFIYVHDMMGVNRPIMVREYAKVAKRECGNWPQFRSVSGGKCPFIEEAVHQKREKERERQIEKMERTRQKELEMSRGRVTKVNAREELVKKADRNALVEMNNSERRLNRNGVIGKDGLFQVPPIIPAKRTNVHSANEVAFTSAYPDKNRGGEPVASGVQPSNITSAIRSQMISSIADQPGRRAGTSKTMIELNRKVLVGNSKGIPASRRMMDLTNAAANNQNLAGGGVDRRRRPGLDQRAVMREDRSEQERRLKAKAKSSKAATKRECRPGYCENCREKFDDFEEHTFSRRHRKFATNDDNWAELDDLLSELKRPLKSSARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A971</accession>
    <name>A0A2T7A971_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1060383</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A971"/>
    <dbReference type="STRING" id="42251.A0A2T7A971"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU84286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="585" mass="63129" checksum="2B97BE67776DA68A" modified="2018-07-18" version="1">MSPKPPKQPPPQGEKESHQSLLSASAEGAKFLILLQVTSRLLTFIVNQLLLRYLSPSLLGISVQLELFMISILYFSRESLRTALQRQPSSPTTTTAAAAPTSTKSPKIGSKLIEGTPAAQRQTVINLSLLALPLGLLFAVTLSFFYARSFASSETASQPFFRESVCLYALATIIELVAEPYFSLAQLGLRYKARATAESAAAFVRCIMTCGVTVAVAKGGFGEELRGRGVGPLGFAVGQVGYAAVLLGVYVWCFWGEGGRVGWSVGLRGIESRWVFFLLRTKDNCRPLTSLAASMWLQSALKHLLTQGDSLLITYFTTNHAQGIYALSSNYGSLIARMLFQPIEESSRNLFAKLLSSTAPSGENITSAKTTLQTLLKIYLLLSTFFISLAAPFAPFALSLIASRQWTAASDAGETLSAFCYYIPLLAINGVTEAFVQSVANERELAGQSAWMFAFSLGFAAVGWVFLRVLGWGAQGLVAANGVNMLVRILWSAGFVRGYFSRFEKEEERRKEGEGWKEVLPNWVFLSTALGVGVLARGVVSEGSGGTVRMLASAGGLGVGLLGVWCYGKLTPNKKPTPFPSTRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9R4</accession>
    <name>A0A2T6Z9R4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1138667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000654">
        <property type="protein sequence ID" value="PUU72215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9R4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="314" mass="34183" checksum="0034542C79FCD44A" modified="2018-07-18" version="1">MALQNSWGVRHAIMKHFYEGVLCHPICPPPNGRLHTSIFYGTIESSEGGSLCQMFLVLGVYRVLTLKPDSQGVKYAIAKPIYDGVLCHPICPPPKDIPGVSGMQAWSPFMTAFYTIQAVDRQKGVTIRAFSLALQNSGGVRPVITKPFYTDVLHHQRCRPPKGRPHTSIFHGATEFSKGGILMPDFLNSGGVRHAIVQPFYDGVLCHPICLPPKGHPHTSIFHGATESSEGGSLCQVFLVMGVYRALNLKPDSGGVEHAIAKPFYDGVLCHPICLPPKGRPHTSISHGATEFSEGGFLMPGFLSSDSIARFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAD3</accession>
    <name>A0A2T6ZAD3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1111748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000537">
        <property type="protein sequence ID" value="PUU72429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAD3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="118" mass="12654" checksum="BC0D5BE07F94354A" modified="2018-07-18" version="1">MAPIPFVHRDAKAVLSTLLSTKSSATSPEGIDIAGLNGHVTPSLLPSPPPIAPLELPVPAGFELGPLEPEKEPLSETARLQSPDVYEGMVSNRWNSNHKRSSMILVSFIDRDAYTANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAF0</accession>
    <name>A0A2T6ZAF0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_907400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000530">
        <property type="protein sequence ID" value="PUU72468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAF0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAF0"/>
    <dbReference type="OrthoDB" id="5415522at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="7604" checksum="BAA0EE34BCD1CEBF" modified="2018-07-18" version="1" fragment="single">MPSNQGYSYKSSGTNSQGNHYCARDYGSGAANSNAYHYSNSDGSYYYSNANGSTYHSSSSGQGTYTPPSGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAT2</accession>
    <name>A0A2T6ZAT2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1104315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000501">
        <property type="protein sequence ID" value="PUU72583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAT2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAT2"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="444" mass="49959" checksum="DE83E920672C3AD0" modified="2018-07-18" version="1">MDTPPAQEVAEAPHEDVLYQRKGIKILGVQLPPWRSPLAQGSFMILTGFVCFLCPGMFNALSGLGAGGQVDSTVQSNANVALYTTFAFVGFTAGTVLNYFGAQATLAFGGLGYAMYSASFLCYNHTKNEGFVLFAGAFLGVCAGLLWCAQGTVMMSYPTENEKGRYIGLFWAIFNMGATNWDTPNHGSVKDGTYVGFLVLMLCGAVLAFFLVPPEKIIRKDGTRVQRIRHPSMTQICGLWETIKTDTYILLLFPFFWASNWFYTYQQNCYQLFYFNLRGRTFTNLWYWLAQIFGALIFGFFLDNQRIGRRKRAIYGWVILFVAINSICPTNNLTGKDFTWYLILYMMWQTYAYWMMGALSNEPRKLAYFAGFYKGIQSAGAAVVWRLDAAKYSYASLFGSSWGLCGAGMILAIPVIWRRIKDTEITEEDFVTPAEKDIVMSEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAU3</accession>
    <name>A0A2T6ZAU3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1059482</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000495">
        <property type="protein sequence ID" value="PUU72620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAU3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAU3"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="10">
        <location>
            <begin position="45"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="9">
        <location>
            <begin position="237"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="507"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU72620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="538" mass="59728" checksum="381EBE186490E8C3" modified="2018-07-18" version="1">MGFKPTSIQPDLATIIEHARKARAADSTTSPNIYPVFAQIPAEFLNPSSAYLKLSAKSKSKLSFLFESASSRETIGRFSFLGCDPRKVFKTGTGHGPEIDPLTQLEKELATYRVGKIPGLNLPSMSGGAVGYVAYDCIKYFEPRTTRPLKDVIGTPESLFMLYDTLVAFDHFYMTIKIISHIHIPEGDLSEEKLKALYRKAQMTVSEVIGTLQSADIPLPPQPPIRKNQQYTSNIGQEGYEGHVRKLKEHIVKGDIIQAVPSQRFSRPTSLHPFNIYRHLRTVNPSPYLFYLDCKDFQLVGASPELLVKSENGCIITHPIAGTVKRGKTREEDDKLASELTNSLKDRAEHVMLVDLARNDINRVCDPFTTTVDRLMTVERFSHVMHLVSQVSGILRSGMTRFDAFRSIFPAGTVSGAPKVRAMELIGELEKERRGVYGGAVGYWGYEKDSMDTCIALRTMMIKGGVAYLQAGGGIVHDSDPYDEWMETMNKLGANMHCITSAEEKYASMEAEDEDSGSDINKIYHPSANSNVHLGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAY7</accession>
    <name>A0A2T6ZAY7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1137071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000490">
        <property type="protein sequence ID" value="PUU72662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAY7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAY7"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="769"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="880"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="472"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="892"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="989" mass="109296" checksum="BC62224F8C736AEF" modified="2018-07-18" version="1">MFTATPPSTYRRRSGSRKVSTEEDQRAMPFIPTKSSYSYGSPHSNMPKAPQLADTRVPMAVALQQKQDAAEARMRAEEREREKASGEQLQDEREEQDEQGFQDEEDSRRLGPTTITTTTTTTTQTPTTGKRGGVTTRAGGKLNAAEIKATMNDVRLRSLRGRSVASDLSQGPPTARSIDLMPPPPLANGRQQSEISDRSSIGVDTTIGFNRSYGSEDDLDPMLGKKVSENLARRFGETEESEVEEQEVAQRRAPAVRRLVPAPSQPIGRKARGADNRIPAASLEFIQSKIGDSSRVLAGKRARELEREKLQQEIDNARLARQKQKELLEREREAAKSTKNPGGGGGDKGGGGGGGGDRGEGDGAGNGDTDSDDVPFNYFGFVDFLWQRWLGVSISGVIKTVLVCFLATIITHYLVTSYGLGFGWQRGGPDFTYIPPSEAPRNVDELVHRLHTVEKELGNFGHLASSFETKYRQVLEKELSVLERSLTSAEIESSTDRDKIKKEISSLSNTLDTVKDLQNALLEDNKRKLDKLYSAQQALDQELSDFKALQKVRNEAMQSFEEALPKQMVATLGPNGKVQLTDEFKNSLQDVFSKIFPKHFKDAISRTGPDGIGKIPSWEAFIKGNEHKLRDLIEKHASAGDGVGGGGKPGGVVLSKGTVMAMVQEEAEKYHKKWEVETFLPDFESKFESQLEELQRRIRRENTEHFNSASSSILAAASAIASGTASKAARSMAQEFANSRGGRGTIERISQGSKELWATLPDYASIITGASVWPYVTSPSYDWTGGKGYHHYVWRLFGRGARISPPPALAITPSTEVGECWPFPERSGDIGIKLAMPIYVSHVTIDHVSKQQAIEISSAPKNIEFWVRVPVERKEELQKAVGKPPGEWYHPNNDTQKKQQQLQTPGSGSNGGEWVRVHEFMYDIHTAGSPVQTFELPVDLTRLNITSRLVAFRIVDNWGHPNFTCLYRVRVHGYPPKKDLPIGESEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB31</accession>
    <name>A0A2T6ZB31_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1096738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000480">
        <property type="protein sequence ID" value="PUU72695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB31"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="86" mass="9314" checksum="D8723434D31210D8" modified="2018-07-18" version="1">MATRIRCAFLSVRGWNVLSIGFMTDHSRVSCVHLLLLLFRMVGGAVKDMALCFSGEFCGGGSVGVLSHCDIFFARGNRGVWARMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBW6</accession>
    <name>A0A2T6ZBW6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E1-E2 ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1136293</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000438">
        <property type="protein sequence ID" value="PUU72959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBW6"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1171"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="200"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU72959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1209" mass="130230" checksum="D4FA76420D6479F7" modified="2018-07-18" version="1">MPVLNESRISRLSGCSEEKLITTLLVSNLHCSSCSSSIEGLLSELSPPPLDISISILDHTVTVTHTQLLSPLDIIDALLEAEFELDSVESTSGARDSMIGPSSSSHIISFQGDTSDWLVDMQTRIRAMGGNKRAGGEMHLKNCELCRNGANEEKMLASSQSSMRTGWKDGATAWKTEVSTGQSGFEDMQAPVHASAGKMYEAVMSVGGMTCASCTNRVTEVLEALSAVESVSVNLMGNSATVVFSAGGMDKAELRAQELVFEVEETGFECSLESLNALGGEGSAVVRGQVGVERAVTLKVEGMLCDHCPGKVVDVLESSFRGELLSFTAPITRQSGLVHLKYTPQPPGFTLRHITAAISSVSPEFVVSVYRPPTMEERSRQLQLRERNQLLIRLIICIMIAFPTFMIGIVWMTLVPKEDQVRKYLEEPMWAGSVTRTGWALFFLSTPVMFFVANVFHKRAIHEIRALWRKGSNVPIFRRFYRFGSMNLLISLGVSISYFASVALLALDAVTKRPMEAEGVDGHGGALIGMEGVGNSGEPESGPHTTTYFDSTVFLTMFLLIGRFLEAYSKSKTADAVNLLRGLRPSEALLVVKSDQEDIAADVAAFNASPTQSPIGENDPSNSEYADNRTWTSRTISTDLLEVGDIVSVVRGSSPPADGTVISGHSQFDESSLTGEARLVPKSEGDFVYAGTINQGQVVNIRVDCIGGDSMLDQIVKVVREGQTRRAPIERLADVLTGYFVPFVTLLAVTTWLVWLGLGTSGSLPASYLDTDHGGWVVWSLGFAIAVFVVACPCGIGLATPTAMFVGSGLAARFGILAKGGGEAFQESSWLDCIVFDKTGTLTQGGEPKVTDERILVEDGEAKKIVYAIAHKLEGGSAHPLAIAVVAHCDTKKMCHLSVIETEETPGKGLYGVFGMPDGEVFEGIIGNERFMEENGVAGIELHTVILDSWKLAGKSVVLLAIRKRGTTDKEILGSGYRLAALFGATDPLRPEAPNVVSSLQESGISVWMISGDNEKTAVAVAAMVGIPAENVIAGVLPTEKADKVAILQNTLPKRPRTRWGRLFHHRNSPNSKRAVVAMVGDGINDAPALTIADVGIAIGSGSDVAISSAEFVLISSDLRSLLTLTELARAVFRRVKFNFFWACIYNLIALPVAAGVLYPVGNRNIRLDPVWAALAMAFSSVSVVCSSLMLKTRWWGVGFRPKQERYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBY7</accession>
    <name>A0A2T6ZBY7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1136106</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBY7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBY7"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="329" mass="36344" checksum="8FEEFC1A7FB306B5" modified="2018-07-18" version="1">MKAVVMEDVREGGEIPPAETPAPTRKKTFFLIQVNDTKVGMVVFELYNDQVPITCENFRVLCTGMAGRVTHPHGTVDRLHYRGTRIHCIIKDFIIQAGDITKGDGSGGASIYANGREPFGYEGFDQENLGWRPIDSAGLLCMANRGGNKSNTSQFFVTLSPADYLTPLYTVFGHVIDGMEIIEEIGKIQVGYKDYPKVKIEIVESGEITPSGHVRVLSPPAPIICRPLQNAPVLLPQPKSAKNNSAPILGHKRTHSKQATMLEAQQEAAEVAAGRGDADENRHPKRRVVMFEQRDEDYDMEVGVVEGDISIQETPMEKNALAMKRRAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCC1</accession>
    <name>A0A2T6ZCC1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_571270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000409">
        <property type="protein sequence ID" value="PUU73140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCC1"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="43429" checksum="871BA59FD3941410" modified="2018-07-18" version="1">MSGAKYLLLALPSSVARSNDPEDAFEALTSVISSSLNKNDASIHRFPIPEFKIGTLDALVLQADELAKLDANVEAAVVKVADVLKSVVGEENAEGHKTVNDRPVEDYLQGFSWNKVKYRSDKSIAQLLDSLHKEVISLDNDIKTKFTAYQQVKSNLVSVQRKQTGNLSTRSLATILKQSDFVPPSEYLQTQLIAVPKPLERDWLKSYETLSPMVVPRSSREIQRDSEFILYSCVIFKKYSGEFASKARAAKFTPREFAWSEGAAEEDEREARDVEAHERRLSGETLRLARTGYSDLFQAWVHVKALRVFVESVLRYGLPLEFVSAIIQTNPKNAKKIKAQLDAAYSYLGGNAFGRDKKGNIKDDVGDLGAGMLGDTEYSAYCYFEFDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCJ5</accession>
    <name>A0A2T6ZCJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000408">
        <property type="protein sequence ID" value="PUU73166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCJ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="19382" checksum="76754ACD02D1373A" modified="2018-07-18" version="1">MFPAGDRFAVTHRSSPGTRKLFPAGDRIAVIHTPRTKNQFPTGDKAGAAFRYRGTRNKLFLARDTAGPDSRYSGTRQKLFPARHRFAVTRSSSTRTRKLFPAGDRVSVQTTLEIYSQRDAHNSGTSKEWFLAGDWIAVSRYPTTGYLFPAGDTIPTPIICPFSSMNAAIIPSLGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE08</accession>
    <name>A0A2T6ZE08_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000349">
        <property type="protein sequence ID" value="PUU73723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE08"/>
    <dbReference type="OrthoDB" id="5420368at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="21916" checksum="D9683EBDC484D927" modified="2018-07-18" version="1">MVANSVQVLRIDHRKRLKERKEGEQDFGAMRWTVENDQLLFLKLIDSHEVSVKPQKIQDGREVPTARAISERIVKLRSAVRTAPAGATSSSPRSTQTTPRRRKNVQDNGKKSPSGSNVHLLGDASKEQGPVRKRKRRLDTTSPAVVKEGLEGGSSASVPLGFGIFGAEGWGDEPSRRAGTEEHNLEGEEEEGKRKEGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEM6</accession>
    <name>A0A2T6ZEM6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000333">
        <property type="protein sequence ID" value="PUU73929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEM6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="20217" checksum="C8EDBF00CDE677C3" modified="2018-07-18" version="1">MSSRLFFRQAIQPASHLCHRRTPYFRASVLRTFSNMNTTESPNFEKQTKNDKLAEPDTVQGMIQKLEQDIAIESASTNVTTTNGTQFENLTATRLKWMFGFGVGTFLLGVFGTILKVGYYDSLRDQQMVAHIEDTSRNLELDMQSKFAALQQVTILKTDHLGNKLDTGLGGGGSNSTKKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEW9</accession>
    <name>A0A2T6ZEW9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_494750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000331">
        <property type="protein sequence ID" value="PUU73954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEW9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="51" mass="5980" checksum="DE3B22231196F2C6" modified="2018-07-18" version="1">MTFNRRSSHSILSFSQRSLSHYHIEWRISSLPSLPFRVSSPLSFKSLFPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF62</accession>
    <name>A0A2T6ZF62_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1196480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000323">
        <property type="protein sequence ID" value="PUU74096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF62"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF62"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015440270" description="FAD/NAD(P)-binding domain-containing protein" evidence="4">
        <location>
            <begin position="19"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="64722" checksum="9CF57F47879C144C" modified="2018-07-18" version="1">MPMKVIIIGAGWSGLVAAKIYLQVEPHIDLTILESEETIGGTWSRARIYPSLLAQQRYRRYEYADRNIEIEGENRNAYVPALKIHAYMNEYAEEFGVKQRIRFSTSVSRVVRNEDRKRWDVWIGDGSELMTCDRLIVATGLTSKPVIPNVPSQKSTSKVFHTKELGTHHDHVTSPAVKNVTVYGAGKSAIDAIYSLVTNGKHVNWIVRKGGGGVPLLLTGTADEKASDDFPTSRLSSILHPNLYTDDWWHWALHSGKNFLGQWLHWKYWERATNSMQSNGEYAKSENMAKLAPNIVDHGAYWLNEGITVLTQPDILDWIHRGDQINVHRNTIEKLEGDQVYLDDGSSHCADVVIYATGYDITQPAFSPEDGANLGIPVPIQQCPPEIAAKWDRLEEVADKEVVERFPRLGKPPPHERVSMSHTPYRLWRNMVPLPLLSGEELDRSLVFIGTAKTYSTAIVFEVMALWAVAWMSGRIHPGKSFAEMEHEVAVTGAFSRRRYLNLGHKFTCQFFDFLPIVDHLLQEIGIKSQRKPDAAADFFEPYVPEDYRGIVEEFKKIHGISNDEETREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF69</accession>
    <name>A0A2T6ZF69_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF69"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF69"/>
    <dbReference type="OrthoDB" id="5396257at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="505" mass="52683" checksum="86212B58B6D02969" modified="2018-07-18" version="1">MSAAVADTSYSLVHGRPIRPLPKRRLRSRLSDDTNAALFGPPQQPTTPLFYFPYNNYAGDQDIGGASVSSGFGLGQHSTGDNLQDSSDEEDNSNASVSRGVGSGVSGASENTPSQPDSYEWSENTNNKKKRKIPTPANPGGSSGGNGGGGGGSHSSPGFSPTSSTSTPRNRWKSSGPSQRSPLSAISTGNQGSLRRTGRRYPSSPSVETPTKRPPDGRSPSSGPATPSKGSRRNAGVVAGVGSPKQTQFTFVCESPVSTSLAFSSASYKSTNANKPGDGSGYPKSMHTVGTQTSPSISNTNANYPPAPQQPKKKSGQARSAATSRRDYALQRRRRQEAVGGGNGNGEIWICEFCEYESIFGEAPEALMRQYEIKDRKERRKLAEKRRLLEKAKQKGKKNSGKNGPSKKGSYSYGVHHGINSGTAPPPPPPSTTDSQGTQSDNTPLASATHTPALKPQRHSQQVQTEAYLEDTDSHVSGGRGANGACGVGSGARSGGGGGTGLGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFW2</accession>
    <name>A0A2T6ZFW2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_893026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000305">
        <property type="protein sequence ID" value="PUU74346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFW2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFW2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="115" mass="12500" checksum="7F01ADF5D3BAAE58" modified="2018-07-18" version="1" fragment="single">IITALEKIKEEMAGLHRGVEAALQNSEAILEIGAAIQETQEALLQGQVILRQQQVCIIQSVGLTDSATAPSEKNRIARLTNRRANRDNTVLEPLYGLNGQSVPGFPRTLGDAKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG45</accession>
    <name>A0A2T6ZG45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_454665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000303">
        <property type="protein sequence ID" value="PUU74394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG45"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="21280" checksum="1B4F4247B377489A" modified="2018-07-18" version="1">MPSLKTVKASKPDCVSPWQCTARHRTVSDLPKPIPSSAIFQPPRFSYRIVSIATSSCQTDKKPDRPMNGAIVGFQVSPGSLRWSLRENMVGRQTGAGHIAKADLHDGRFGRKGRKGKEKKKKTWFAIREVHHRIVPYSCTLLANSKSIWKSRRQASRDCPSTRVCGSWQHHEFRILILYCAFGIGGYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGV4</accession>
    <name>A0A2T6ZGV4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGV4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="13434" checksum="D6DBB67E1304A7F9" modified="2018-07-18" version="1">MIHLPSRTRPLTSRPAVHHPWPTFKVFFGDQADEFGHFPEALPSQNTDDVGQSPEASPSPDEISHSPEASPFQKTDGVHQSPEGSPSQKASPSPKEESGIRGEGGFNTKKSGGDLADVSLPLPTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH02</accession>
    <name>A0A2T6ZH02_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1156816</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH02"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH02"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015470286" evidence="3">
        <location>
            <begin position="19"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="241" mass="25395" checksum="14FB327FA235B9DE" modified="2018-07-18" version="1">MKFSIVASVLLNIYTALAADVCDKGGYVTTSSNYIIYNNLWGMGSATSGSQCTGLDSASGDGVAWHTGWSWAGGQGQVKSFANANLIFTPKTVANIKSIESTIEYSYTGMNGAVANVAYDIFTASTAGSKISDHEIMVWLAAYGGAGPISSTGKSIATVTIGGYQWRLYDGYNGSMHVYSFVAVGSPLTYFTGDLKLFLTYLASNYGLPTSQYVNTLQAGTEPFSGTNAKLYVSTCSIVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHW2</accession>
    <name>A0A2T6ZHW2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1031617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHW2"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="1">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="32825" checksum="8620E353C1379476" modified="2018-07-18" version="1">MAIHSSDQAPSQPAAPAAVILPTEHSEHTVVAVLASPPPARPATITIPISRPAPSTPSNIAHLEKPILRRDGLDRREILLRGREGSRRRQRWENDRLLSNPHAIPPTASDWEVRPLYPRRHVPYEFASLYDHPKFSHKENPTANRQVTEKMPKELKVRMKKTRGAIGLLKSLEEEVRKFVLRGQDEKAREEEGKGDVVDDESDEEIVFISKRAKQLQLETEKVLFQSPVSDPGASFGRWLVHSIATYYGLKSWSITTGNPAKRIAYVGLKKDPKNSALVVTEMPKPLWLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI18</accession>
    <name>A0A2T6ZI18_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1154909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000249">
        <property type="protein sequence ID" value="PUU75131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI18"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI18"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015539366" description="C2H2-type domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="242" mass="27975" checksum="E72B8CA67A8393A3" modified="2018-07-18" version="1">MQFARRLLLLRLSVLPREIMCLNSSSNTERRKRKAYSDGKVEWANVPLDMDLDEGTKNDEPAYLQPQTTQHSNEEDAPYAPIVNDSDTSFHPHSDPSPAPLNSLPEQWISSTRTRSGRKPYDRKGSSRRNKTKAQRGEPRTKKPKPNPKPKIFPCKLGCEKSFVRNTDQERHCRTAAIHNLEKPWECPLCGTKFNRQDNLDQHLANEPKKCKLLQEEREAWGQLSAYIPTSQPWFQSLQHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZII5</accession>
    <name>A0A2T6ZII5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1110140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZII5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZII5"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="7">
        <location>
            <begin position="133"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="662" mass="72398" checksum="ED208E41663A7687" modified="2018-07-18" version="1" fragment="single">MREPNPCKIKTRQFEAFVSFCGMLAIVVWEHILQESYKFCTGPFLLYHGFGHCNYHHHDHTLPNQASPMEVIALISGGKDSFFSLLHTIANGHKIVALANLHPPTTASDFITTHLPSTTPSALLPSALGAKDELDSFMYQTVGHTVLPLYPRALGIPLYRGAITGTSLNQNLSYAHSGKRGDETEDLVPLLEYIIAQHPGVKAVCTGAILSTYQRTRVESVCERLGLISLSYLWQREQAEILADMETVGLDARIVKVAAVGLDPEGWLWKNVTEARRRGMLNGLERKWGVHVAGEGGEYETVVVQGPGWMGRIEVPEEGREVVRSGGGVGHLKITKANFVPGEGVMGEVQQMGWVKDLRIPYIWDTEFERILKTIISTILIAPLPPHPSLSSLPPSRLNPAPKPSVSTFSQSLFINNLTSPPPSPSSPHQGITAETSSLFQTLSTILAAHSASFKHITTCTLLLRQMSHFSLVNSTYSTYFTDPLPPSRICISVGDLLPLSVNIMLSVTADLSFSPSQLRRGLHVQSRSYWAPANIGPYSQSITSSTGWTSLAGMIPLVPASMELLNNAETRGEVVDQAVLGLQHMWRVAKAAEVAGFLGCVVFVTRCEAVGPVVEAWKGAWKGWRGEIGWKGFWSSSQSSSKMEQDNEGEEVEEEAGFSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIT6</accession>
    <name>A0A2T6ZIT6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_353521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000234">
        <property type="protein sequence ID" value="PUU75393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIT6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015750212" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9162" checksum="4064C659B352A2E6" modified="2018-07-18" version="1">MELGILQVAHWLLYFAFLHNASTGLSRRRVTLREVFYPGSDSQGEGMYPHIPEALPVTHGVSGFGGETISTRECSRTLRIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ08</accession>
    <name>A0A2T6ZJ08_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_353530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000234">
        <property type="protein sequence ID" value="PUU75394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ08"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015785751" evidence="1">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="137" mass="15678" checksum="53834CD5669A103B" modified="2018-07-18" version="1">MGNMPPVRQLRATMYLVVYGHLWTGQVLAQDPKFEMTILFTKEKEQSLYHIPDSPSIPPYPSPPTRALRNRINPKAPAFTEFIHPAHGKRRNDLALVHWDAFSPWVSRRFTVYGTSTVVHNAQGNPRDDVNSRKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ96</accession>
    <name>A0A2T6ZJ96_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferric reductase NAD binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1067330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ96"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ96"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000029">
        <property type="entry name" value="NADPH oxidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="234"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU75569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="546" mass="63236" checksum="661C4D182E950A64" modified="2018-07-18" version="1">MGQESWWHRELTGRRLLFWIFWWGTHWGLFAFGWWKQAVDPRLAGLNTLQYSVWMSRGAGLVLLFDGGLIVLPMCRNILRVVRPKIKWLPLDESQWLHRQTAYSLLLFTIIHTTSHYVNFYNVEKTQIRPVTALQIHYTQPGGITGHVMLFCMMLMYTTAHHKIRQQCFEAFWYTHHLALIFFLAFYTHAVGCFVRDTPEPFSPFAGKIFWKHCIGYQGWRFTIWTFGLYFFERVWREVRARKQTEITKVIKHPYGAMEIQFTKPSMKYKSGQYLFLQVPAVSRFQWHPFTITSCPSDPYISVHIRQVGDFTKALGEMLGAGSDAQGIEGLDPMGQYEIAVRNGMRMPTLRIDGPYGAPAEDVFDNEIAVLIGTGIGVTPWASILKNIWHKRDNPGSTPLRLRRVEFIWICRDISSFEWFQNLLSSLERQSDSKSHEFLRIHTYLTQRLDVDTAQNIVLNSVGMEVDPLTQLRTGTQYGRPDFPKLFTTMRDGIMDQSYITGLEGTLRTNVGVYFCGPSAAARSIRKACATASTPEVNFGFWKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJB8</accession>
    <name>A0A2T6ZJB8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1053701</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000223">
        <property type="protein sequence ID" value="PUU75588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJB8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJB8"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000004">
        <property type="entry name" value="Ethylene receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000289">
        <property type="entry name" value="Osmosensing histidine protein kinase SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="488"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="20">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="18">
        <location>
            <begin position="663"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="19">
        <location>
            <begin position="1053"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="520"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="816"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1191"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="615"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="14">
        <location>
            <position position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU75588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1230" mass="134292" checksum="E581FC553CFDB9AF" modified="2018-07-18" version="1">MRIRIREQLSLLVALTALVAVGVLAVVTWVHNYRLVLDVRSSRFSLTASLKSVQVTQSIALLYNTVYAISTRAILQSALRRYQKGNNTMDNWSRTIDDLKNSGSADMGGFPHVLQMVVYDENLSAGMVGVPDGTVIDGMRLSAANPNFTGTLPNGTMIKIGGGLGGRMGLLNVTGDNADGVMLPGDPVNGNVTYPMLLANPSPAYYAEADANLTKGLPVKDGFPHALYPFLQGSQALAPSNVFTPEDIYSKRGLLLGPMRVNESFYILSLTIPVINNTSEATLLGFLTVILNAGAILDITQDARGMGSTGQTILVGPATPDNKWADDALSAISETHTTTNNQSDSTGPVGITRRSSLDWDTSSPESAIEWVGRKLGLRKRALPEKIGDYEFRYLFPPGRHPGLVGQARRLKDYPMVKKVYQSGIGVNGRDGHNGDGGGSNLDTRNSEGRLVSAGFSIVEIVKNLSDWALLVEQDQEEAFKPIYKLRNILLGTVFGTFAVIIALVCPIAHFAVKPITRLKRATEKSTRPPSYTPDGGSSGVIDSLDPEANLEDPENEDRGRNRFYGMGELMRRRRLRRNSSQSGDGSDEQRRRAFRIPGKVRERKHIIDDELTDLTRTFNEMSEELVKQYENLEERVAERTKELEEQKKVAESANQAKSLFVANITHELRTPLNGILGMCAVSMQEDDLPKIKRSLAVVYKSGELLLHLLTDLLTFSRNQVGHMAISLDEKEFRMAEISTQIKAIFETQANESKIDFSIIIAPEKTVQEMVFWGDSNRILQVLINLVSNSLKFTPENGAVQVRMRLLQEVLPVPEETTIRRGSSRTGSKRDQGSRAVSRINSTNTPRNGSPAASSPPPTSQAASPPITEKVGDQILVDRPMLGPPPNAKTYMFEFQVEDTGPGIPEHLHQEVFEPFVQGDLRLSKKYGGTGLGLSICNQLAKLMQGTIELKSLEKAGTTFTMKIPLKYVKEYTPSVGPSSAAIDRALPETASARSVQSGVSFGKNHKPRLVGLSQPFFAPSIPPNPTPDQELPEVAANGGMHEHRGNGETGRIRVLVAEDNKVNQEVVLKMLKLEEIYDVTIAKDGQEAVDRIKEALDVGENFQLVLMDIQMPNLDGIESTRIIRHLGYDAPIVALSAFAEESNVQDCLDAGMNFFLEKPIRRPQLKQVLKTYCSTIKEECASSVEQLAEGSASAGTTPMTTPPVEAAGEKSIGGSVGGGWEFGKGERVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJQ6</accession>
    <name>A0A2T6ZJQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_993321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000217">
        <property type="protein sequence ID" value="PUU75721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJQ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJQ6"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="284" mass="31354" checksum="03691AC08962085D" modified="2018-07-18" version="1">MTTLEAHALNAGYAFLPQRLLFNDTTPANANTVDKFPAHFFHLHHPDKNLHFLWDAGIRNDISAYPPAMQATFEAFLHPYVPEDAPSGLARNGVAPESIDYLFCSHAHFDHAGDPEKFPNTKIVYGAGTQAHVRPAYPINPESRFLESLFPEGRTLELTKGDFKPIEGFAPWDAACDFFGDGSFLLIDAPGHMPGHTIALARVEAGYLLLGGDSCHCEAHLKEYVPGGRMGFGMHKDAGRTRENISKIVEFAKARGDVRICLAHVGIYKDWEKVVVKQGEGLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKC0</accession>
    <name>A0A2T6ZKC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1089221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKC0"/>
    <dbReference type="OrthoDB" id="5395110at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="17669" checksum="AD8EAB9028AA3485" modified="2018-07-18" version="1">MAENRRHRSSPPGLPPLLTLPPELLLTVAELLPLRYQSRLLRVNIHLANVLTPLLNSAANQTAQAGGMPLLHWAVLHNDVRLIRLLLAKGVADVAYPGYCKYTALHLAVAHRGVGVVRVLLEGENGKSVRGVRDCCGRTPLGIAMRGGVGEVVEMLRGKGEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKG9</accession>
    <name>A0A2T6ZKG9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1130491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKG9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKG9"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="213"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="392" mass="44590" checksum="ACED0CBC19949BB5" modified="2018-07-18" version="1">MSELETLERRGSPPPNALTEENLNTLSPAHEGAARASDNESVLSDIDEGIFQDFDDSLIGRIVPIDDETVHTIGKYKKKLDPSQLAEKSGKKEKRRRDIKRRRDDIEERTGEPEPQEQELTAEEKARRELDLRMDAALKGPKKKKKKGEDLEEMNDDLIIALKQRMIDAANRDQEAIVNGQQAVHKLAMLEEVKDILQRPNLMATAMDNNLLEAMKRWLEPLPNKALPAYGIQKVMFEIMGKMKITTDYLRESGIGKVVMFYTKDKRPQLHIKREANRLVRDWSRPILGRSDDYHSREIPMAHDGDSRLPRFKQRGDNEEANPLAPPDRNKNRTRVPQAMPRSYEIAPASRVVQGHNAYARPIGAAGDDIIRRMKAKKQAANKGKKSGMIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKS9</accession>
    <name>A0A2T6ZKS9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small-subunit processome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1088983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKS9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKS9"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="801" mass="89126" checksum="74BEC1BF40F127A4" modified="2018-07-18" version="1">MGSESGSGDEGDGESMSDFSEEEDETPEDSSKLTKLQEIISSLPSMVKPSRRAQENDPNEGKAPNEYNLTIPSASDKLTVEDLMSTVADPRLKQSLKLIASNAPPKASKSGVQGKLSAPLAKRQQDKLDRPAAYEKSKEALGRWTDTVKHSRQADRLHFPLANAPNARLPAPRKVTVLSASEPTLLTQLEATISGILKESNMASEKSIKEFEELKTNKLSVEEVQKRTAELRLARELLYREEIKAKRIKKIKSKSYHRILKKERVKHQNAAEEALALENGGAPNEEDIMERERKRAEERMTLRHKQSKWSKGMKDSGRTIWDEEAQDGAVEMAKLSEELRMRTAGKAILGEDEEFESSGDEEDDLFNEDQQQAKQRLLADLEKLENENDSAKNQHNKSKLMGLKFMQNAEAARKKANKIEVEGLRQALEGDDRSDRTDEGEEEVNDTGRMIFRAGRKKKEAVVGKPEPGKSEFEEAERSSEDGDGEDSLDETEVTIVNKSSSGILKNPFSQPGVSPLQFPSRKAKTSEKGSTLSRPFPKTRDEAPEPNPWLAQGSTSGLVRPKAQALVAGRQESKNAIINSKLSKDRKQALKDRNGPELDIGVDVNAMLKFALNKRKAGSDCDSGDGEGSEDDEGAISLVPAKGKKGVNLDLRELAKRAFAGDNVSAEFKAEKKRKIDEEGDQVIDTRIPGWGNWTGAGLVERKGKKDARFLKTIKGVDKNKRKDKKLEKVIINEKRVKKNVKYQASALPFPFESQQQYERSLRVPIGPEWATKTTFQDSTMPRVMVKQGTVIEPISAPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLQ0</accession>
    <name>A0A2T6ZLQ0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1088337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLQ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLQ0"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="326" mass="35675" checksum="C3571E84063D8AE2" modified="2018-07-18" version="1">MPPIPTPSSRELLQRVKMFIPPLLDKMHKGQQGRVAVIGGCEDYTGAPFFSANASALLGADMSHVICEPQAAQVIKTYSPNIMVHPYMRQSHHTQEGMQSAEEISQKTIDLLERLHAIVVGPGLGRDSLMQDTAAIIIEAAKARNMPMVVDADGLFLVQNRPSIVKDYSKAILTPNKAEFARLCKTMEVDPQGDEIEVCAKLARAFGGVTIIQKGPKDYISNGKQTFICDLEGGLKRSGGQGDTLTGSLGTFLAWTRAYRERVWNHDNSLSDSELILLSAFGAAAVTRYCSRIAYEKKGRALQASDLSVEVGNAFKYLFETENPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM08</accession>
    <name>A0A2T6ZM08_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000185">
        <property type="protein sequence ID" value="PUU76521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM08"/>
    <dbReference type="OrthoDB" id="5415394at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="28211" checksum="5F26B293BCFA90E0" modified="2018-07-18" version="1">MNPSSSSSRTNAGKQPENSEEGSPCIPNASFTLYPLYEQAEATKAKIERTVSQLPRLAAQADEYLAPEYLAPEMANVTDVYFDGIASEDPADAQKQIEEAIVRMDAFYNDLSNRMRANNTSRNRAFTEPGPRPPWIFPAGDISCQTGESSANDAGRQQLRSLGILPGEPENDLVEHGPMHPGERVFIMPPPPARRVTFGDSTIIGNSPTGPGFRRSLTFRSVASALKRNPGESKREKVKDLWRNVRDRLKKNHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM68</accession>
    <name>A0A2T6ZM68_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1051783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000183">
        <property type="protein sequence ID" value="PUU76585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM68"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM68"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="90" mass="9023" checksum="A58FEC4E7261D726" modified="2018-07-18" version="1" fragment="single">IKQAVQTCGNSQLNCCNKVEKKGDTTNAGLIGSVFGSGDLGVQCSPINVAALAVQVPVNKQCQANAACCQGDTTQNGVVNVGCVALASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMR8</accession>
    <name>A0A2T6ZMR8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1087633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMR8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="8874" checksum="EB2EAE288D3530C7" modified="2018-07-18" version="1">MRLRNVNGPPPIPVLSQSVEGSEVKAGATESTRKLTGQLGPIFLTCNGEKQSKKVVKYLEAQGGFIRIISLILAQDLNQILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMX2</accession>
    <name>A0A2T6ZMX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1109226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMX2"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="311" mass="35288" checksum="E7220A9FCC063D58" modified="2018-07-18" version="1">MSEIIAEVHAAARKKRGQKEPAPIKRNPRPQAQDAPAEEIENDEQCDAILVTKCVIRGEENMKAEAKASLSHVLLPEQREEFYVEGHESKLFVANQLGLTYGRSLNHLEDTERKLKEARVLIAQYEVEINRLCGEVSLLEDRSRELNLSLESYKVARNRFILVYKRDKLGVRSEADRLAIRAGNATVHGGDAITDASLYTVPVGGREDVGIFEQLYGLNPWSVQRLKYPETVAVLNEHAKVLASDTIEGTEKFYHLFNNFIQLFKETGDGYDEAYLQQENTPVFNAYWRWKREKGDEVKPIPRPIVPAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP80</accession>
    <name>A0A2T6ZP80_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_987354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP80"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP80"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000020">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001075">
        <property type="entry name" value="ATP dependent RNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="228"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="670" mass="74900" checksum="B520AC5FB70A1FA7" modified="2018-07-18" version="1">MASADRATESEECLVSLYRPSTILPITRHRDALLYLVENYPVTIVVGQTGSGKTTQLPQYLHQAGWTEEGKIIACTQPRRVAATTVATRVAEEMGVRLGEEVGYSIRFEDMTSPRTRIKYMTDGMLLREVLVDPLLSRYSVVMIDEAHERSLSTDVLLGILKKIRRKRKDLRIVVSSATLQAEEFARFFGEEGESGEKSKDGDRGDGDGDGEKMELAKIISLEGRCYPVDVLYLEEPTENYVEKAVQTEGEGDILLFLTGREEIETTISMIRERAEDLHPRAPQLLPLPLYAGLPSDEQLAVFDPALENHRKVVVSTNIAEASVTIEKIVFVIDCGFVKLRTFDPRTGIETLSSVPVSRASATQRAGRAGRTRAGKCFRLYTQRAFSDVMVEMGIPEIQRSNLAPVLLQLKALGIDNVVRFDFITPPPSELMVRALELLFSLGALDDYARLTKPLGLRMAEVPVDPMTAKILLNSVTFQCIDQILSIAAMTSVQNVFITHEGSKKPAESAKRRFAVEEGDHLTLLNVYQAFSPKANKPSAAKWCKDNYLNFRALSRATSVREQLRRYVDRFNLQVSSAGGGTPTAEGIRRCLTTGYFAHAARMQPDGSFRSVNGMQLWAHPSSVMFNRKADWVVFHEVVETGKKTFIRDVTAIEKDWLLEYAPGFYQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPB8</accession>
    <name>A0A2T6ZPB8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCA7, zinc-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1086411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPB8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPB8"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="95"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="278" mass="30055" checksum="B0BE841479C06810" modified="2018-07-18" version="1">MAHIKACQKAKSDKAKERKKLKGEKAAAAAGKDQSSIADTNGDVNGDGDEKKKGAKKMMKKDGDGTKSKKRKADEPKLPKEPKAKKKKEKPAKPDPKPKAPVDVEKQCGVQLSNGALCARSLTCKSHSMGAKRGVLGRSQPYDILLAAYQKKNHAKQQKAAINAGAPPPDEIEANNILIDSDEETELVMAAVTRSMPQPLERHILVPVRKKYQYVRMKEMLASALKPLGRPMFDGANAGSLFNTSVVNPASRAMPGIQQGRQYPLAPQSRKGSVQMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPV6</accession>
    <name>A0A2T6ZPV6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPV6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015457495" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11072" checksum="DD1BD08925217C0B" modified="2018-07-18" version="1">MFFIFYFLLTVSITPPPLPIVEASLDSLWFYLVTLPFADASALLTGAENHTSGMQARFHLNCPPCFVLCNRGTSKIPTSCNPNRSCNITRSTLPHLPTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPY4</accession>
    <name>A0A2T6ZPY4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1193979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPY4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPY4"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="547" mass="61822" checksum="4F709FA23476EFD6" modified="2018-07-18" version="1">MNVNFGQVAISPRRFKYLLIQMSLILFTASAMICLLASVVFLLNPQPGYSLPNSLQQILPAYLQTNHHGWGLEPAYQDASNCPDQKGEWNILYHLGGNGPWVEKVDAVLEGGIQVPDGCEVDMAHMMSRHGERFPTKKAGARMITLLGRIKSSGAELKGSLAFLNDWQYFTDSPEKHFEQLITTGPYSGTLEAFTTGVKLRTRYQHLWKKVLDKHTLFWACGCDRVIDTARYFGAGFFGLESKRAELQIVSEDESKAGDTLTPGDTCKNYLEDSELGHDYGYEMLYKYRATYLPAIAQRLEKENPGLQLSDSEIYSMQEMCGFEILVRGNSKWCDVFTRKEWSQFEYARDVIHYYRAGPGNKYGKAMGWLWLNTTANLIAEGPESVGPLYFSFVHDGDIVPMLAALGIFEDTQDLPIDEIMEDRKWKTSQITPMGGRIIFERLSCTPKSKSTEKEIFVRFNVNDGIVPLEGCADGPGKSCSLNDFLEYVKRRGEIAGDFRKLCGLAHDAPDRPTFLRQPYSDNVVAVAEDREVKDDKPKKLRFWGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ81</accession>
    <name>A0A2T6ZQ81_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA-processing protein FCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_986352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ81"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="67"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="22482" checksum="A22E416490692FDA" modified="2018-07-18" version="1">MGVAKRTRKFAQVKRIVSSRDARLKKNQEKQQTATTKKDKSSEVVREIPQVSSSLFFQFNTALRPPYSVLVDTNFLNFTIQKKLEVMQSMMDCLYAKATPVITDCVMAELEKLGSRYRIALRIAKDPRFERVRCEHKGTYADDCIVNRVLQHKIYIVATNDRDLKRRLRKIPGVPIMSCGNGKYVIERLPDAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ93</accession>
    <name>A0A2T6ZQ93_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1115347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ93"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ93"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="119"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="28947" checksum="325319D2CE47FBC9" modified="2018-07-18" version="1">MSSPTATRIDFNQTPLAEVYGNPNNYFAMIIENVFTPTECEELIALAESSGPWIPAAKTLRFRDSLRILRQDSGTARMIYERVEPFLDEVRRPGKELECMTGKKGGGNGEKGRWELAALSEMLRFLKYEEGQHFNPHCDATYNGNGEEKGQRSFLTLHLYLTDDESLNLRGGSTRFWSPGRTKFMDVEAKRGRVLIFQQRMLWHSGEPVTGGTKITIRGDMMFKWVPLKPPRPKGEKKEGGKVDEKAELVKEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQZ2</accession>
    <name>A0A2T6ZQZ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tim17/Tim22/Tim23/Pmp24 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_985092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQZ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQZ2"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="23397" checksum="BC015550D1E4A01F" modified="2018-07-18" version="1">MSFWDNFTGRKTPRSLGTTAISSGHPSDSGDIAPTTTFTRQNTFDSTDISSVSSFLAPAAADPAALHPLAGLDRGLSYLDLEETALSTLPGSQTALPSRGFGDDLCYGTGTTYLLALSLGGAWGFAEGLSRSPPNAPPRLRLNAVLNAMTRRGPFLGNSAGVLALVYNGVNYLVGSVRGKHDAANSIVSGALAGAIFKSTRGVRPMLVSSGIIGAAAGVWAIGLKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR08</accession>
    <name>A0A2T6ZR08_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA repair protein endonuclease SAE2/CtIP C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1065439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR08"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="765"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="875"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="37"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="905" mass="99686" checksum="491E0697EF5562F1" modified="2018-07-18" version="1">MDILGKHRIGFNNLGVQLFADLERDLSLALTKGSSEKADLERTIAEQKELLQERQALVCTPNSPIGVALIDAHEDTSEQQQQKIREQESRLQNLSYEIAKAKIENEALAERFEGIEKADRGRQRRALAITNDKSLENKENILPVFNYLAQDIPSRTLTRPVSPPLKPLNNPRTQSSIPVDEATQTLFPYKDGEVQTDSIPSLDDLKKAYQELASSYNDIRYELDQYKEAYNRLAEKYAQNKAVWKQWSEQENARLINSKKRRIGRGTTEPQTIGRKFNGYTTPATPITGGSPTPRAPNISPVKRRFRPSVIHSSPKKGGLFHELPGSGDGVAGGAKGSFEPVDENSLIAGDPKEGPEELTSSPLSSPPSSLSIPETQAPSKAFEAAQNSKPRDGGDSTESEDEPRSSDHYSGALNEPVLPSRDSAFKVPVIKKETDVCGHGHISQEGDSVARPVIIKSESHASSEGFGYHIFDQESLDLDDIGQKPQTPRKRQKPLHPELEAAENISRPGWISGGFRIASTGDTGETQDTENDLPVLTFPLPTTGEGKPLGIRSDSHLARPTTPVGTARAEPGSSPPFSAANKGSKTPPPLRRSSRMSAAREAISAITEEKKLGVHAPPKTKKRRIATPRAIASFAEDGTDGCEDINPISIHPPMALSEKQRNQLERDMKGTARLDDILNSPPSRTPNLARLKKNIQSRTSPAKKRTWGGDGFEAPPVRPLSSAGSSTSTRRAGGNTKSKARDISTLDISDFRVNPEVNGGKDYAFTETVRNREARKCLPGCMKTCCRDLVGFAEAAGLPAVSKGPRWRSSSPALVEDCELPRRSLRNQSVSKEDKAKEFTNRYGRHRDAFERRRSPPGFWDADFPTTQELEQQRVAAEEMRKKKVEDMRKEAERGSKGRFVFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSD7</accession>
    <name>A0A2T6ZSD7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1108349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSD7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSD7"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF2">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015624328" evidence="1">
        <location>
            <begin position="28"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="431" mass="44793" checksum="E7BBB18DA2FCA2E3" modified="2018-07-18" version="1">MKTTTSALFLQFLFITTAPFLATAASAYPWPAGIDPSKKFWPPGEGPPSKRWLNELAEAFNLNQSFTPESIGRALAVKKIMDPAEKFMPEYWNWNGNREEEEAKGQQVIAANLTFNSPVRRNMFDGYAYGRLFKRQNFQCAIGTHACTNIGRPQSCCDNNEQCFKIQDTGFGDVGCCVNGQTCSGTLTGCGDNKKTCSSREGGGCCTDGYNCSAQGCVPAPGQVVSSAATPTTTTMTSTASACSSGYYACPSNLAGGCCPSGRLCGVSDCPVQTTTGTPVPSGDTCPTGYYTCSAQFNGGCCRIGRDCGITDCPERAITISSGTSQGALAVTTRGGSCAAGWSSCPNNLGGGCCPTGYICAISDCPAITLTGSNLVVSGTTFTGPVVLRETGKLQPTAGITPNAARYGMNVNGVREVIVVVGVVVGVVANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSS2</accession>
    <name>A0A2T6ZSS2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_982985</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSS2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSS2"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="87"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="795" mass="88921" checksum="8CB85C9FEA7C0B20" modified="2018-07-18" version="1">MSTSAVHHHRPTAKQSHKSFKSRHATKSSLKTKSKGKVHDPDTFNRKSPHQQTMSKLDRRNKNRQIAQNKHKDLIRETKIFDGRKGAPRIVAVVPLCEDGDAQAAVRQFKEVEGDIPDIGTITTRIERFKQKIQWIVVKRDLLSVLDACKVADFVVLVLSAKQEVDEHGELLLRSIEAQGISNTIPAVQHLETIEPAKQRPDVKKSLLSYISHLFPSLNKIYAFESEQESSNIIRTLCTSTPKGVHWRDARSYLLADDMRWSEQEGLVIGGVVRGKGLKADRLVHIPGHGDFQIEKICEYPDPPKSVDVMAIDTDMPGPKVLDAPTASQDDLAYLAPEEVYMPDADIPDTISEAPTSMTTISRKGVLLDGHHYFDDEIDEPVTTTPSRPRKLPKGTSAYQAAWILDDDIGSEDSGMEDNDEDMNMTFDDPPVQPEDGEEGLAPPAMTEVGTEFGDEARSEMFLDPAPELELQQIAEFRKSRVTELAEDREFPDEIELHPNVLARERLSRYRGLKSLRTSPWETEEDRPFQPADWDRLAKITDYRSAKNKLTREALVGGVPAGTKVQIYIRNGPANLADSSTPANKPLAIFSLLRHEHKQAVVNLSITPSSSLTAPIKSKDQLLVQVGPRRLLISPLYSQSNTTGRNNVTKFERFLIPGRTSVATFVGPLLWGNAPAIYFQRSEASGELSLVGTGSFLSADQSRIIAKRIVLTGHPFKIHKKLVTVRYMFFNAEDVAWFKALPLFTRRGRSGFIKESLGTHGYFKATFDGRINPQDAVAISLYKRVFPRGSVEFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTE3</accession>
    <name>A0A2T6ZTE3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTE3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="70" mass="8129" checksum="12CACD4F8E80B481" modified="2018-07-18" version="1">MPHGRRRKPKRDPQVPRGLIHKLPVPYGAHVFFKIFSLQSLTEPQYRTGKGGMRMTNSRHPSHLGKIPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTI5</accession>
    <name>A0A2T6ZTI5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1193073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTI5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTI5"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="106"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="358" mass="39038" checksum="B116659D35ACADA4" modified="2018-07-18" version="1">MVHSSHQSLEDACADIAYAVHSLNDPNISIITPAPHPNPATDTGWSFPDTQPGILAAIAAGANTIWANTPLFADHPLITTSLPPGIKLIANPPKVVDVVDDKAFTNKLLQHHGFPTPKSWLLEGDPERSIERLGQLVYDLPYPVILKPVRGRGSEGVQLVNGFVGMLDALDDLLNIYSIVLVEELLEGEEGTVTLVPDGQGNFMALPIVQRFGQVSGVMPVLSVREEDSWHRAAKIECQKAAELLKLTSVTRIDIRKKDENGGKFFLFDVNHKPNLTGAGRPGRDDQDSLCAMAAKGFGWEYPTFVRKCIETARYLEEARTIEPQGTVVGSLDNFTVWEKWSGKGNDGVAGNSDVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTN3</accession>
    <name>A0A2T6ZTN3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1108057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTN3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="8877" checksum="62E7BDFF2CE19642" modified="2018-07-18" version="1" fragment="single">LTSLVFLPGVNYYRRLPLSDRDTICTGTASDILEYKAFFSFFQLFVLFGCGGGWWSFWSSLAFYCKALDHTNGYAIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTQ6</accession>
    <name>A0A2T6ZTQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mitochondrial ribosomal subunit protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1083170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTQ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTQ6"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="107"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="29194" checksum="81EDD823C48EE354" modified="2018-07-18" version="1">MASPFFSRTTRLLPFHRAVIPTPPTIRPLTTTPTPAYDHPILISTTTQPPSSSPSDGRDPNELEEKDWDGDDFTSSGHAELLRHREARAYARLAMYEMPLLSKLSKPFLPPSRAEVLRFRYTTYFGETHPAEKKVVVEFAPRDLSDLTEVQRGKLVKLVGARFDPVRGIVKISCEMFALQAQNKRYLSDLVDRLVLEAKDDRDDFSDIPFDFRHYTAKLKRPKARFPKAWRMDEGRAARIKEERAAFVKLFEGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTV5</accession>
    <name>A0A2T6ZTV5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTV5"/>
    <dbReference type="OrthoDB" id="5418867at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015425699" evidence="1">
        <location>
            <begin position="25"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="258" mass="26999" checksum="AAB39D3BE7CA106F" modified="2018-07-18" version="1">MASMVWPFVVHGACLLQLFANVLKHHVVKLDYQRLAQAMGDNVTPKAISHRIAKIKEKAQAHNNRWDPYIRLVASTKRVASLKPAPMGMPSEEGDDDEGKRIVDLKSEDERLSGAGLGDVDGGGGVVVGSQMLRFDQSGGGGGGGGGGEVRDTVVAAADHSGGGGGSGDCEKYFLRVDGQGRWPVPASEFEVYGMYEPTEGVVGKDEAGIQLPCAAPSSYPSAIVADDDELLQSRSESGSRGGNGGFCHEGAVCENVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU50</accession>
    <name>A0A2T6ZU50_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU50"/>
    <dbReference type="OrthoDB" id="5301632at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="843" mass="93239" checksum="B3FC5657EDC7EB26" modified="2018-07-18" version="1">MRKISAYTILCLGTAIVHIRSANGHLSSSQSTDTDGLAPETEPYRLAPLAVKNDENNDPLVPEIPNAKSHYNNDPFYLDDFEPRDIIVPAPDFSAIDEFDLASKARFKRAEPTVDRAGGPHPPPAAVLATTDVSKEMAISEVGILVDATKADLIPKICDSREFKPTLENYWISRTDDFLRDYSRDNQGFSNYQRDGLLKSLAKKYLGDDTYLDCSFHGGIFSTKKCNIACSDVLKHVNDVALGRKVYFSLAAAVGFSQVMGVMHDSFSEVPERLASMVGLMPEIEHALAELTALDVISSEAQLFSEALRHAVVAAAPWHSVEKVFEKADADLAQVRNDYGSALQVYEMIEGGSDPHRLDKLFNKNYEPSISDLDLPRSDAADHVLEASSASTEAWHGKSVQRAKQALLDSVAFIKTIGTGELGRARESGYSVLEDLFNHIRDVTGSDMDASTAEVPRQVAARSKAAIVEAVEKILRGGSVGSDGSTNLSKLLSYGNFLPLGNKQNLSKFKSANPVEKLTKNIFMRLFDLSFDRNKIYVSCTKDAQRRSNPRKDEPGPKSSCKRDNSGPQNLKACVGDYTCYMYRWSERKFDYLSHSKEPKGMAKWGDPPFNISAEDIITSSVLSQLQGLKPGKSADSLSDILEATADGISSLDNPQHPGVFHLPICFSRQNWNTQVTGWGTLCDTDPHCPAKNFPCTCGAWGQETDFVWREMGVGQDEKRKNYAQHLCPRQISRKVDDPLERYMAYCALDIRRNSPTTRVNGLVKFAGKDKYCAIFQSIIALKGYESIEDIDPEVKFAFTCKIKKGGKGCSMYNKMFEGLWKGAFDAGYLTSASEPKELYSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU84</accession>
    <name>A0A2T6ZU84_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1125668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU84"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU84"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="38214" checksum="776CB3C3B3EAAF1E" modified="2018-07-18" version="1">MAPSKFSKIQTDLTRLFCVEHPVLLAGMNVAAGPKLAAAVTNAGGLGVIGGVGYSPDMLREQIAELKSYLNDKDAPFGVDLLLPQVGGSARATNYDYTKGKLGELIDIIIESKAKLFVSAVGVPPKAVVEKLHKAGIAYMNMIGHPKHVQKALDAGADIICAQGGEGGGHTGAVPTSILIPTVVDMVKGKKSPLNGLPVTVVAAGGIYNGKSLAASLMMGASAVWVGTRFILAEEAGAPKAHQEAVRTAGFDDTLRTTIFTGRPLRVRRNPYITNWEENRKSEIKELTSKGIIPAEHDIEQLEKEDKLDDDTMDNARPFLMGKVAAVVNDKKPAKQIVDEMVDEAVVMLQKGQKMLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUJ5</accession>
    <name>A0A2T6ZUJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_844834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUJ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="193" mass="20821" checksum="5952AA9D3C742C30" modified="2018-07-18" version="1">MDRAQEGLHLPARCKLRSLTSMVQSLNPLHNFVFSDVMDPKQAGNLTGLPQSSQLDQKIHITSQTRHITHPTQSLTSPTPTHTTPFSASSPSMSSPCPSVPALLAGHRATQPMEFTQSSSIPTTSIRPPAVNSSLTGHPSKLASPPTAWPSLLLLPPLTLILPILFTKPHSSENDHIFINFSSFSSSLSILFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUR6</accession>
    <name>A0A2T6ZUR6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1100968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUR6"/>
    <dbReference type="OrthoDB" id="5356231at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="125" mass="14141" checksum="8F2EAE89389A6595" modified="2018-07-18" version="1">MSGAEIVLGVAGLLGPLMAPPLESAFRHLRKPHYNHHQAREELRGNFIDSWSTLQGSLSRLAPVLGTLTHDDPDRRKVLREMEKATKALRKVNKGLLGCKPIKRALREQEKTEKIIRSVDSWWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV74</accession>
    <name>A0A2T6ZV74_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1081789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV74"/>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="646" mass="72625" checksum="7E79D5168844BB42" modified="2018-07-18" version="1">MSNSVSDLSAPLLRVSRPVSACSRCRSAKVKCDGKLPACTACEKSGKGHECAGGSDQFARGKERSYIASLESKMEKLEKKLAALESRKAPSGSVSSNGFSDGNSRVTQQNHRRDRRSITPGSPLPNGAKAKTKKREEANEIEDLVADLGYMAINATTRDFYGFARDMTFAKVVLKASTTSKALETKPRARLPPRYTATQLIQHYFDKIFTTLPCLNEASFFGAVDSVYRDESRCSPYDIYTVYMVLAIGTMSLSKSRDSPAAHNAACFVKSALEHADAVISPSAITGVQAALLLVQYSMLEPAHFNSWYLIGIASRIMVDLGLHQEPTKSLRKKSADMDLRRRIFYCVYALDRSISMVLQRPFTFSDDSVLVDLPKLEDPEVAKQIIVRGTLTPMATAIHLFRLRKLQSEWYQFLHLSGSEPVQDPTAYFRSKTAILKEWLGKIPETINSSTRDWLYLEWYYLNVYTAAPCPKIPRPCDEAITQVFQNCVSYALMFRSILQNSNVRFVYTYHDALRTYFIGNNFLHAFWRSEDTVITGANVTSAIDAVKAIIFVLTSMIVRWQEVEVLRDKFRVESGYMLRNLEARQQALLAPPRPQVTREQAERTLRHQLSIEWGEIDGASPQLYNPSGHIAMADLGNVAFYRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVM0</accession>
    <name>A0A2T6ZVM0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_823597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVM0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="17365" checksum="428F542838D5BB24" modified="2018-07-18" version="1">MYFLIPVVRYSLPVTMYSSTVPKNKACEFVRAFRYARIFPLYISQNPRFPVLLARYEYSTCTQLLISITRSTGYIKDLVPFCSTGLERDRVNEILTVRLYPGAGEILANVIRHSNDLNFRKVESTGSRCLPAAKILYVRQDGVYRAKPRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVX0</accession>
    <name>A0A2T6ZVX0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_810544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000086">
        <property type="protein sequence ID" value="PUU79622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVX0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVX0"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="568" mass="63212" checksum="2724CE6202F11CE8" modified="2018-07-18" version="1">MDRAQSDLVVWYKLETEFFQDYVRHTRYLEKAKKRNEKVEEDWSNCGELGRGGFGVVHKQIRKDTGHYRAVKTIDKRLPAKLDYSRELLVMAILAKHPPLFVEFLGWFEEPETLYIAMEYFKEGDLSRHTCAPLPQETVKNISKQILEGLKVMHQHGIAHRDLKPANIFVVSMSPVWVKLGDFGVSKRIRAQATTTFHTQVLTQVYSAPEVLGLDSNSETSDYTNSVDIWSLGCVIYELLVGKQFFVSEAQVSRYFFGKKPFPEDKLEGLSPPTDNLGISLLKSMLVIQPEDRPTAAGALSHGWLTGLRTGNEHSVGGQDETTQSRGETTPGRKRKIGLATQNRMKKRRSRRNPIALDSTKCIPVGVASEASAGSQCGGDPSALGEPVANTYVTTPSDAASLRSSVVQAGPRKPKLVPHNSQAAHSIGLRAPRKKKIRNISHTLPENHLQAIPRRQTFVVEIISHPPRRQTGATEHTPQSTRKFRNSTPDETVARITIGEPTLPCITDPCKTVPKIQSTKRNTRGAGDGRNKNVPTMNSIQSQNTTRSPSTENDPYTRQTPIAGRNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVY6</accession>
    <name>A0A2T6ZVY6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_802376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVY6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015444154" description="Secreted protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13063" checksum="5B216A9BA27B90E5" modified="2018-07-18" version="1">MLRNCFLHLSLLSFFSWITLPSTSTRRESLARNWLLDDRFSLLFGPPVCGIPVSPSVAFSSLFFFTGFTRLGLKQGRSPFGGSVLQHRTANNTQGEPFVEKGKKIDQLNKHSLCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW96</accession>
    <name>A0A2T6ZW96_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Non-repetitive/WGA-negative nucleoporin C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1080986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZW96"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="11">
        <location>
            <begin position="139"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="10">
        <location>
            <begin position="700"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="969"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU79761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1372" mass="152233" checksum="A4C6D918946FC5CB" modified="2018-07-18" version="1">MKPNILEPITKNDPLLTFARDHHAKTLYAGANFLFLVSTASLPFHSMFSSNHLSAESAAAARRRHRPTSRPSSRTQHRQERSGSNASMNRSVRESSVISQRGVSGSFTERELFSLGKAMTMASARGDGKNTDGGAIDWTKNNKFRVSKLPALPPPLKTANPAPITAATEGSNGYALVLSHTAAYVWQYTSSDTIPHTFSFPLPNDEQGANSPFPLGALVSPSANSDEPGLVVVMPLSGRTAYWDSVGSAVAEGLFSKRRGVEGKVPLISGESVTAICNAEPAGFILSLSSGRLAHLALRDPAGRPGITVTIMRGYGTGMMGGFLGALRAGSSRRDIVAVRAGRILRMGEREIIVATARGNFSRWQANRSGTYANITDIDARDNILSAIEQVAPDEVQLRSKDAFVIVDAAVGENHDAVEGDNHDVDVLVLASFMPTPNSPGALHVLVSLKFRSSGRLDVCDVHVVRCYTTPLEEGKTRPRLYLPRPGRTAFLVFSRAVVLVSTQKPDVDDDQMNEDTEDRGAFEDVVDFRGDLNVEIVGSGPEDVMFDSTPRSDMMGSFTSDAGATGAGKKTRNPGVMLVARGAGIVRLEAFDLEPVKESVPTEPAKVKSKIEQAVFYGVKEDNPLNFKGRKETKYGIEEVEEAALEISQEILSSTSEYLPAVLPSLDTHLSLRAAHLRALAEHLRATFPPLSRKTMWRLLTDAEKCHAARAVWTVREAHLRHRQEGEEGALEVIIPELLASDDDIGGSDPIRTWFLRYIGSIEDLIPKAKHAMVEKTSKGRYEKVTMAKMDAEANDIVLAALMKAWDFRVRSVKLYRLDKPGVDSNGIMNKTTGLLPPWTSGTDILQALSVHHEVSVAMIKTLWGPRLASDLEGKEVIERVAEQLVGLAEACCRGFEERSLWCEQQSEDGEGTLQEGITIKERYIAQRGGWIKPLAELGMPEKAYELAEKWQDYRTLVELCSEEIIRIETSQKELSNATSNREAVERENAELAHTKKQTIERMEAYFDKFGEVYAIEMYEYLVENGQLQKLLNGFENWRETYLTRFLRSSKRYAKLSWIHDVGLGEYALAADTLLEVATEQEEDQWNKKVELSIGKLAKIAAMGYLDEQSVRNIDSELELVDIQNRVYEAVKVIGKTSIDTDGAVQIGLEKYAGGTLTSKKRAGCRELWKRAFARAVEGMVMGVEELADLLTLVDSDDEGTSLLLHAERGEEFYWALKALSLGGLPLERRKFTEKSIWRRCFLRDNWQAILDTRNKTDKHVQAATYDTAVYKTIKFGYERGLFAQNSPYQPLAPEETFFSDSLEELRTRFARADESELKTIGFDLSQENKLLTRFLEKAQLRVWFPGVLDAARREAYGEHVNGEEREAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX96</accession>
    <name>A0A2T6ZX96_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_759373</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX96"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX96"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="18639" checksum="52DA256BFDEC4E52" modified="2018-07-18" version="1">MSFGGFPLGGKGLGGTSSSSNEPLTPEQQQMQMVKTIQAGMESCPVKTVISGGMGFGLGAVFGLFMASMSYDTPMTGLPGAPALQNLPLKEQLKRGFKDMGQRSYSTGKNFALVGSIFAGTECCIEGFRAKNDMYNGISAGCVTGGFWRRRRDPRRRLLGVQALRRLVLLLTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXT1</accession>
    <name>A0A2T6ZXT1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ADP-ribosylation factor family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1079690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXT1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXT1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="19804" checksum="262B9369CB91C574" modified="2018-07-18" version="1">MGGVSSIFSRLWSKKEVRILILGLDNAGKTTLLYRLKIGEVVTTVPTIGFNVESVTYKNLNFNVWDLGGQTSIRPYWRCYYANTAAVVFVVDATDHARLETAAEELQAMLNEDELREAALLVFANKQDQPGVLGAAEISEALKLPSLKERSWSIFGCSAVTGDGVNDGMDWLVKTVQEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYF6</accession>
    <name>A0A2T6ZYF6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1113858</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYF6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYF6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="144"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="820"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="820"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="981" mass="109869" checksum="9B4C837887989BF1" modified="2018-07-18" version="1">MSTNAKQAELRVRILNQRLPTSVARVLFFPDYALKDVLDYNVVAEVIAESEIPLHDQSGVIKDILSGAQKIFCILVCIRQVNYMHLLLRSGIVDAKLALSKEDLRASDLPAPTVDEFWEQQWEFIAPIFKSRVQKLDSSCILPFKEVRVLGEGGYGAVTRVVLYRSHQDLVPDGPGDTVVVARKSIKRVSTKKTEKLFESERAPLEFLKTRGHPHIIELLGSYSQADGYNFFFPLAEGSLKDLFDKGKQSFGIDTEHFYPSIVGLSSAINHIHNFTYEMSGKNMNFKGYHHDLKPGNILIRQGKFIIADFGLSKFKADANTSSTLHRVGTIAYLPPEAANINPETNFEDPTVGRGVDIWAFGCILAEIATYLLRGSEGVSEFGRRRITKVSASMKDDSFHAHGEVKEEVKEWLRSLTATAERGTDPQITRLIQVVRKALIPDRKNRPIARVILEEVTVLDPEAAINMELFVTQERKTLPPSPPISPAGSPQFRPQTTSSVSGASGDYHGIDVLSEGTRDPELQMDVVAIHGLNGGPHTCWQGGSGSIWLRDFLPSDGMHLPRIISYGYDSEHLFTHLSKANLEKEADNFLRRIQRRREAEKASTRPIVFLAHSVGGLLLKQAILLAEEGDQYQDLFKSICGVTFFGTPHREHGIQYTLGACLRKIAKTASVSEQIRELIRENMGENERLLKMVNYSFKTKVCIPGGNLRVVSFYETKPTPGLGVVVDEYAGTMGLNDGNEDVCGLELSHPDLCRYSSETEPSYKAVLRRVLCLTRISADEYSSKKARQLKQEVPYINNDQRFSPEIHVNNIIRQLQQWPTTPQPTQHSNMTLPLQLTTTPTPTPRVQTKPPQPPPHTLPKRKQPPPPPSPQPQTQARTALPQQPQKKPQTQSRASINAIEEKLAKVNRNISSIGADLAARQKERKALKLRRQERGEVWFSNETKSIEKRITVLDTRRAEARLEAESLKRGLARARAAHQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ03</accession>
    <name>A0A2T6ZZ03_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_702087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ03"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ03"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="241" mass="26160" checksum="2E6789F37E8C93E4" modified="2018-07-18" version="1">MPPIRVGIIVFDNAEILDFTGPMGVFTIAAQPPFTSARPPFPQGPPYRAPPPGSERMAFDVAILSQNQTIRTSHGRGCVIMRDIDLFSPEGHEDKWDVIVIPGGLGTRLQMENLHLLDWISRFARSYRGRRKTILSVCTGTLLLAKAAILDGMKVTTHFSARETLRSIIERGGGVAEVVEDRVVAEVLRGSVGEDLGVDVVTSGGVSSGIDGALYVVKTLVGLDVARGAAQWIEYNWNDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ18</accession>
    <name>A0A2T6ZZ18_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ18"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17305" checksum="B57F73B367E92DE1" modified="2018-07-18" version="1">MAMHKVFARTRGGLRMGALFRPGSEILSHRSLAASGPAVDGKIKDMRKFAGRFDMVCSRFENRISTMQATMDSETATIPSILKSKLKALESSTKRNIASAQSELEGQISTINHVLWAGSSVVFTVGAASGYVLMVFFQFYKPNFIDSWNAAISTWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ38</accession>
    <name>A0A2T6ZZ38_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_973906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ38"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ38"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7160" checksum="0483CBE1E0A12CD7" modified="2018-07-18" version="1">MEGSNPEHGLRYQISKSRNCICPSGKLFLNGMKSNYGGLRAENLCAIVPIHTAVNERAWKEIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ39</accession>
    <name>A0A2T6ZZ39_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1078571</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ39"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000005">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="401"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU80768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="449" mass="49163" checksum="B8AB9A3425D147C5" modified="2018-07-18" version="1">MSFFGLYGDESEVSPMSDSFIFTRFGQPPHLLFNNAQQQSATAAVVRAQQQQQQQQHQQQQQAQAAHIQQQQQTIIGLLGRGGGGVSAAGLGGVVGRAGVGVGSSSGMAIDARGPVTTPPERSMIRDVWAQDLEKEMAVLRDLVETYQYVAMDTEFPGIVARPIGNFKSKADYHYQTLRCNVDMLKIIQLGITLADENGNLAKIDGSVCTWQFNFKFSLNDDMYAQESIDLLTKSGIDFAKHAEEGIDVYQFGNLLISSGLVMYDDVKWISFHSGYDFGYLVKIMSCLPLPKEESEFRNLLSKYFPALYDIKFLMKSCRTLKGGLQDIAEEMGVSRVGPQHQAGSDSLLTGNIFFEMREKFFDGKIDDAKYLGQVWGLNGAGISPPNINGVGTVVYNNGVPVPSTPTIDRNGQDPGTPGSTTPSQQQQQNGQPGTPNQYNLQYGKMGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZA7</accession>
    <name>A0A2T6ZZA7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZA7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZA7"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36403" checksum="DECA4F313D071D02" modified="2018-07-18" version="1">MSNSSPSPFTSSHNIIRRPGYEMPTAVPLARGRAGAGSGPSGAPPEGEVPCGKEIGERLKDLVINRRNGLKNMYGETEEELNKSLEAPIKRGEEMARKLSTEMGCSREVATDLAVLTLYYVAILISDSQSMINEENGARKQTLIQFVDHITEICSMVSGSGILAMRFMNRGGDHHSYGGATRIGTELKKKKILDKFAIGNPNQSKPLLVLIITDGGVEGEKRGHLKNVIRDCVNEREGAGKGFDAVAFQFSRIGNDSGAAQLLTDLDGDRDIREYVDVLPVKFDPECLLADKWFVQFANNREQWGEEEMMDHLSDSGKYAEYTDPGDDWAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZB1</accession>
    <name>A0A2T6ZZB1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZB1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZB1"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="184" mass="20085" checksum="9123062694114981" modified="2018-07-18" version="1">MQEAFEEDGFEGEFWSKTRPDALGPGLPVARESREVEGLRLICNLEPAGLPIDREDMDPNCVDNRGQTLVHCAGRLGQEDMLMRLLGGDDAELNRMNNEGRSPLARTLQDGYVGIVKTMLPVGCPGVGLILGDGDGRPLLSLAAEADYQYVLRMNGENVDLNSVEGDRQIPLSWAAAGWWGMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZK9</accession>
    <name>A0A2T6ZZK9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1078144</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZK9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZK9"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="401"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU80927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="739" mass="83753" checksum="1687F16009A726B8" modified="2018-07-18" version="1">MASNTGAAYGTGAELDAAGARRRIVPGESAVGGDVIVPTPEDTKKRQRIDQAGDVDIEAIVAPILFTLLSFFTRLYKIGQSNIVTWDEAHFGKFGSHYLKREFYFDVHPPLGKMLVGLSGWMAGYNGSFEFKSGEVYPDELNYTFMRVFNATFGALCVPLAYFTAKELRLSKPAIWLVTLMVLCENSYATISRFILLDSMLLFFTFTTMLCFARFHKLQTKSFSPQWWLWLVLSGLSIGCVCSVKWVGLFVTGVVGLYTIEDLWNKFGDLKMPKVVYAQHWVARIVGLIVIPMVVYMWSFWMHFTILENSGPGDAQMSSLFQANLKGTELTDSPLEIAIGSRVTIKNMGYGGGLLHSHVQTYPEGSGQQQVTCYHHKDANNDWYFHPNRGQPDFDPESPDLRFVGNGDVIRLIHGQTGRNLHSHTVSAPLTKADYEVSSYGNLTVGDEKDHWTIEVVSDAAGRDYSKLRTLTTAFRLRHTALGCYLRAGNVNLPQWGFKQIEVTCTKKNYPRDVFTHWNVESHWNEKLPNADVKAYRSPFLRDFIHLNVAMMTSNNALVPDPDKQDDLASAYWQWPILHVGLRMCSWDDGIVKYFLLGNPMVYWGSTLALPLFSLLALLYLIRWQRGYNDLGGEEIDHIRAAGVYPLIGWVFHYVPFIAMARVTYVHHYYPALYFAILVYGFLFNHLTNKLPKTVKLAAYGVAYTVIIGVFVLFIPISFGMTGSSEQYKYLNWLPTWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZM9</accession>
    <name>A0A2T6ZZM9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1043810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZM9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZM9"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="201" mass="22271" checksum="0F9CAE0D57CD0051" modified="2018-07-18" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTVELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVFDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDIADKKVVEYTVAKEFADSLGIPFLETSAKNATNVEQAFLTMARQIKERMGSTTVNNKPTVSVQQGTGVQQGSAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A030</accession>
    <name>A0A2T7A030_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A030"/>
    <dbReference type="OrthoDB" id="5428866at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11857" checksum="6F577619FECC3E7D" modified="2018-07-18" version="1">MGNLCFRPESIRKIEIEIEGLRNDIARLDKDRKASEMKAEGREITVSGGRGSKISDQTTAATMRRAVGHHGGLIGHGESKAIEELWEGFLVMAENKVVKTFGLSFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A055</accession>
    <name>A0A2T7A055_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'-3' exoribonuclease 1 D1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1168418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000051">
        <property type="protein sequence ID" value="PUU81091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A055"/>
    <dbReference type="STRING" id="42251.A0A2T7A055"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="25558" checksum="E5F979B69FBB1186" modified="2018-07-18" version="1">MGIVIDTVEHALHIVISKGWKRRDEGAMVKDSSPPPGLVTHYGLKTVVEEGVSDDWGFLKKSAIPITEEFPEGFSYSLRGEFNYGRELEAIRRDANRVDIRIATMVGTYASESYAVARVHKPRRLVLSGIIPNSTVVIDDSRLEFSLQNESSACIESLACRILYISSISQSLIKCNHTAENYHGQGSRAIAPKLPDLQTCHGSSAHPSAMSTTTPLTTVLLCSEVSRWQKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0N6</accession>
    <name>A0A2T7A0N6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0N6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="11207" checksum="2148BCDE522F8DCE" modified="2018-07-18" version="1">MDRIQTSAQLLAELTQYQQAYKALAKRIETKLGRHEEDARGVRYTAEQIAYRAEMLKHVLEPMYGELHGLGAKVEKMEREFRDLEAAEALLSLRGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0X6</accession>
    <name>A0A2T7A0X6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1077372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0X6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="11049" checksum="B697E32CBF156362" modified="2018-07-18" version="1">MPSTRAQSGTRTYSTKLLSIYHLLLSLIRLHRAFSPLRAQRMILVYLTRCTWGEERLFEKNTSEATEMKVTSILQSTAKDIWARRNLRYGISSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1E8</accession>
    <name>A0A2T7A1E8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1E8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="80" mass="9249" checksum="9805546623225AA5" modified="2018-07-18" version="1">MDKEAQYTAEQGTGRGTEAKILVVVPDIYHKNVLPVYIITCTISSFVCWMDGSRVAVVIVVVLWYRYWYRVWGLIVGHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1U7</accession>
    <name>A0A2T7A1U7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1U7"/>
    <dbReference type="STRING" id="42251.A0A2T7A1U7"/>
    <dbReference type="OrthoDB" id="5383967at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015527101" evidence="1">
        <location>
            <begin position="21"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="513" mass="56563" checksum="E40B51392F7F513D" modified="2018-07-18" version="1">MIYLLFLLLVLPFSLAVAQGEGILPPVEVDCLDPSWVPTVDAWMKEEVDRKLKEWWESIPDRTDKNFVSELGKAFGDFAHNLACGVDTEDQCVNPSCKVFLDAKAPKWTYFVRVAISNLNRFMRLLHAGIGEGQLSFEALREDVAQSFYPFTDSRSKFEKAAPWLTAVFSTAAAFIPFGAALGGVTKTVPQTLIAGVSTAGGAFAGGAFVEITRDPAIKQIVKRIAQLSEMGRFVADYCATARDILGKWSMVIFKGVRIGPGVISCSFFTFLLWSSSKPLTWSSVYLRGGRFILQDEWTKSDLENFFKKRLVAWFVNSQIREQTKTFILCANSTDPESVISPSKAKGKYIASNGTRVCSLYRLNDGGELKDPVAVDKLKQPRYNITARDMIQSSVEAYLANGLNYTAENMTSRLQISATLPSDQQWFSQGAAGEGAFTIPVCDVGNATELMGIGCKDTQSFMNSTKMGGFKPVENECRAPEDYGNDASSWLKPSWRVLAGVFFAIAVANFLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1V6</accession>
    <name>A0A2T7A1V6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1V6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6527" checksum="D3761EF647016F6F" modified="2018-07-18" version="1" fragment="single">MLLGADLRTCSWESRQNETSFFHIFFFGKPPSLYNGRWRYGNPVSGCLRALIWWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Z0</accession>
    <name>A0A2T7A1Z0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B9Z19DRAFT_971086</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Z0"/>
    <dbReference type="STRING" id="42251.A0A2T7A1Z0"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="21">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PUU81728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="355" mass="40167" checksum="81C27B2B8B859D03" modified="2018-07-18" version="1">MSTTKSLPSISTAELEGHKSASSCYVTIGSKVYDITPFLGDHPGGEDLILDYAGKDVAKILVDEISHTHSESAYEILDDYLVGFLEGSRPPSPPGTPAATGSLTGMSSEEELSIPTDITADYKVHKFLDLNRPLFMQVWNGGFSKEFYLQQVHRPRHYKGGESAPLFGNFLEPLSKTPWYVVPTIWLPCIAYGTYEASKGLPNNWTVAVEYMLHRCLFHIDEKMPDNRVAITMHFLLHGIHHYLPMDKLRLVMPPTLFLALATPFWHLAHTLFAFNWYVGTNVFCGGIFGYVCYDLTHYFLHHKSLPSYYRELKKYHLQHHFADYQKGFGVTSKIWDKVFGTELIYGPSGSVKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2G3</accession>
    <name>A0A2T7A2G3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_970301</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2G3"/>
    <dbReference type="STRING" id="42251.A0A2T7A2G3"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="515" mass="56780" checksum="128DF3532CD4133F" modified="2018-07-18" version="1">MILRHLRALAPSISAPRRFYSEVLQTKFGQPSFETHPWLLKTGEVTPGISALEYATRRAKLASGLPDGAVAVVPASYVKYRSGPVFYPFHQNPDFLYLTGFLEPEALCVIEKTGPVGSGEHTFHLFVREKDSHAELWDGPRSGVQAALDMFNADEAGDIEHAEHHLRSILERASAVYTDAISPTRKPSGYARLIAPPLAATPGSLVQILEDKKVLPLKCFIHGLRVFKSEAEAANMRKAGQISGRAFNKAIAAKERFTKESDLWAFLEYKFRMGGCEKEAYVPVIAGGQNSLHIHYTRNDDKLGESDLVLVDAGGQYGGYVTDITRTWPISGTFTPAQRDLYQAVLNVQKRCVSLCHEGVHISLDEIHEVSEVELESELKRLGFDLTSSRLRSVLFPHHVGHYVGLDVHDCGSYPKSRKLRAGQCVTVEPGVYVPDDLQWPKHFRGMGVRIEDTVCVGDEGPVVLSVEAVKEVNLPPSSPPTFTYLPNPFVTANREPNVVQIVDIESLAAGITTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Z2</accession>
    <name>A0A2T7A3Z2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_968181</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Z2"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Z2"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="583"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="305"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="486"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU82420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="842" mass="91675" checksum="FC552295C94B3D32" modified="2018-07-18" version="1">MDSASASNRSENKPHGRRLTKNPPSTRAPHFVSPGLPSAKSWSSGSIQRTPSAPVLPRSTHGKSTGGHQRTPTSPNPQAFSSSSSSLEQTNPSPQLKQDGFRQQGQSDLPIQYFNQLGVSSRPVSGRLSEESTSEGSGFETSSRRNTLRRPPPPPLAYPNTDEMTTASSRPQLRQSNSFTMGERATSPPSPPKSYTTGSGGTLSPKRNSDEVRMQAPPSAKSKTGFSKFMNSMLGSPKRVEISNPSNPVHVTHVGFNFITGEFTGLPKEWQRMLQESGITKKEQEQNPQAVMDIVAFYSDVSGGKGEDGVWKKIPQQDSHGLGLPGQMTPGPSPLVSSPLMSPPISPRFPPNHEHSFENPRAPPPIPAGQKSRSGPISPGLPRDGPSNTLVPTRPAPRPPASPPREPGQINPYLPRTTQPAPPPPQPSYQVSPIEQLQQDTYQPHEETRVAPAPAPVTVHQSPRIPREPSPPRSNDPFRNGPYESNGPQVTSKVKQSPALQQTHFQKPVVQNQSASPTTQQGLTRAPTAASGQAVQAQAPPGGNVGPVPVQRRQQHRKQPSKDIDIVTRLNAICTNADPTRLYRSLNKIGQGASGGVYTAYQVGSNRSVAIKQMNLEQQPKKDLIINEILVMKDSKHKNIVNFMDSFLHRGDLWVVMEYMEGGSLTDVVTFNIMTEGQIAAVCRETLQGLQHLHSKGVIHRDIKSDNILLSLEGHIKLTDFGFCAQINEAMMKRTTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPRLKEPDQLSAELKDFLHSALEVSPDRRASAGELLQVSCVPSNCGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A420</accession>
    <name>A0A2T7A420_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Tht1-like nuclear fusion protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1120785</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Required for nuclear membrane fusion during karyogamy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KAR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A420"/>
    <dbReference type="OrthoDB" id="5311848at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048288">
        <property type="term" value="P:nuclear membrane fusion involved in karyogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007292">
        <property type="entry name" value="Nuclear_fusion_Kar5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28012:SF1">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN KAR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04163">
        <property type="entry name" value="Tht1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0415">Karyogamy</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015711252" evidence="13">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="421" mass="47526" checksum="579C62F0B2B9AC70" modified="2018-07-18" version="1">MLFLRELLLTLFFWSTASSWGVFRSRTSSLSIPDVWVKPLGHNPVLNDDSENFTPFFEIDEAYEIALAELNQLSSKSSCHKIASESLVGDCRSIGIDGEEDENSRILFGVQLAACEFEVDGLEFPYECRRFEGTREKRVRRAKECLQKLARKSQWWTSYSNNRANGFSMCSAARREIEKDEMINVHRNITKTHQSLFTLIEVSLKDAWRAANMQTEATAKLKKSIEDLAEDYRGAKRNLAEDTTRMTDTMNGNLERLYERGQTAVGRLELSIHKVRTAADRQVNLMDETLSSISSTMENSLEKFRELDVLAESQIMKFHAISGTYGELTGAHQKLTESSEKLVQIMGNVTEALADIDEKVRSWEERISKLGHSAGLPVASFLLGGAILGRGWGRLNSILVVIIGNCKTRKYLEELLTNAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4A1</accession>
    <name>A0A2T7A4A1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1120548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4A1"/>
    <dbReference type="STRING" id="42251.A0A2T7A4A1"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04401">
        <property type="entry name" value="RhoGAP_fMSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="41"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="985"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111271" checksum="5C7471CCE6E35AA6" modified="2018-07-18" version="1">MPTFLNKVFKRDLAGSSKKVEQSAPPPPQEVKHQDAWLRTEVAPEQVQELLRGCTQEIKSRGLSTPFLLLPFRPNSDASAARTFIRNFFNPVTGPLRGPPLQQELRLTEPVVLCSTLKWCWSRLPGGVVTWDVYQLFRQGEVDSSMARDSFATFIPLSAESEARSKIIFDFFDLISAIAAHGKHNGLGGMKLSRLAGWWAFEHSDMGWGFEGGYTSWSRAADATMHLFFAYLRSLSPADGTKGVSVLPISLKALMASVDYPPTAPSQLQSKTVRVVMTVETVSPTPFSLLRRARNFQFRENDLALRALIDYDDPVQALSEECKRVLKCISSTNQSSSGLNGGNGLQDQSWSRFQDLGFSGLLEESDGSADEDGLSMTGSETFRRRRASTQPTPSTPHQEHGMDIARPTTPSWADFMAGGFGDRDQGPNQPAPLLLPPDKILPPIDSGSRVRSSQSNRKIAEDNLDPGELASVSPLIVDDAFWWVWISSLAGEESTARKAVFGRCALVETVIKGGRWLVVEEKVKGAATAVEDATYLLAKEKKKSRRGKLGRRKSVGRADIPIEPPKQFDPSVGLFNRTNIGPDQTAKVQIAAAALRQQQVQRERNHLRPREEGSKPNPRTNSVFTLQPVILSEATPAMKWASKYDRDAIREAYLKGLPMPEKKDLSRVDTDRPLPPPPPQEELEEKPERRERQERPKPEPARPKAEQLTQPPTPITKQAPVVPASPRTPSAPRPVPMALPSPRSNGRTSPTFDSRSQTIPGSPKSQPSTNSTPEKSKKLKASRFKNLFSSKKADPTSLVGRRISQLEPPNSGGLGVPAQNANRRLSVNRKQNTPVVGFYGDAAQFKAPPPPVVTKKPSPSPQAGLRRQDSDQPSTSQVSPNEGRAAAQVFSSFGQGPLTDQPAFIPDDSVSTPEPVSPIESGPAAPEAEIDVVSIDGAAPPASPTEANPMQDRWAQIKKNAAERAKAVPKASDEYTTSDARGSIDDGETSGEETIESRVARIKARVAALTGNIDTTTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4D3</accession>
    <name>A0A2T7A4D3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_967224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4D3"/>
    <dbReference type="STRING" id="42251.A0A2T7A4D3"/>
    <dbReference type="OrthoDB" id="5400671at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015575372" evidence="2">
        <location>
            <begin position="22"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="170" mass="18343" checksum="1B8717AD7AC6D6A1" modified="2018-07-18" version="1">MQAKVFVSYLLAIILAVGVIATPIDVEGSTTDASTVFENAGNSFSGAPDPRPNEPIITPKEGDVPADSTSVFARDLESLEKRTLGCVRMTTNPNFGGLPLRACGLPNGYCVNLATWWRYRVSSFSPDPYTFCKIYIGAFCSSGASLMFGSPGYGKLGKWDNNMGSIKCWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4E7</accession>
    <name>A0A2T7A4E7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1074742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4E7"/>
    <dbReference type="STRING" id="42251.A0A2T7A4E7"/>
    <dbReference type="OrthoDB" id="5429993at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="566" mass="60789" checksum="2197B4160B438E4C" modified="2018-07-18" version="1">MPLPVPSPSRLPRHPGNSSPPTATIRRVSPPTSRPGSSSKSKMMPSSASGNPRLSPPRPVSMLSPPSGSWAAGPVPEVIEDSSRMPPPPVPTGRTMSMRSNISNSSSGSKGKSKKSDEPKKHKGLGKMLSLRSHNKPDSPEKKKGDESSSRLGRAMSMTFRSSKGGDSEKEKDKEKKSAESKGLLGRTMSLRKSSIASNGKADPPAAPNGPAKAGRLRPNSTYNSSTSSLLKLGAEPTSSATASVARRPVSGSIPAAPAKAHRRSASTVSTASITPSSNSRPGTATKNNTTPPAGNSKRPPFSSFNQEYPQPAPSGPSPRSRILPPPPLDTQTIHQQTQLLQLLTLHSSSGQVYQELIASATTTLKSRFEQLSARHYDVRETSIKRQNRANLDSLALVVNTGSAIPTKRRQTIKSPEELVQAFSEGIKRTDALKTGEFRKLSTTFGEWISGYNSSATGREKWVDGIGENWRYDCDTVERKLQSAVKGIEGVRELFGALGDDDAVKTTVQRVAEGYVLLAGGMLEEVEMMRKMECEVVLKERRTLGARVENIMVGEVKAKEVGIWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A583</accession>
    <name>A0A2T7A583_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A583"/>
    <dbReference type="STRING" id="42251.A0A2T7A583"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="371" mass="41213" checksum="B5F4D58FE1982F35" modified="2018-07-18" version="1">MGRRPTENDNDISPWLLRINKYEKSPSMPFLKDVEADKKGVFGLNFPPSPRAPSSYAGVLGKDRDKGKPGEDGDFNGAQNSPAEKVQDRDLMERGWPGYHGLLQDKGKNIFLRRAASTSAKYDKSARRRLVQRRLGTVNSVLEETTPTKSPSRTVVKRSNSKKRERSNSVSSTKSFLTYATPPEASPTEPDATGDAGKQAGGSLQENFPPVYLLYLLSSMKSGAKRIVKSMESLRDRVTVRTFLCAMLNNVYTLNSSESVARQQLLKNIMSLSLPQTSIPPSSHNVKEPVMVTIRKLKAMPSDPTRYSRADRKVHLFLLISLVDDGAIDLLLGEFMEKMQIQITSIGTMFQLELDGVFGVVCSVEHFRPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5B5</accession>
    <name>A0A2T7A5B5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5B5"/>
    <dbReference type="STRING" id="42251.A0A2T7A5B5"/>
    <dbReference type="OrthoDB" id="5413188at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="300" mass="30780" checksum="6FB769AB7976B580" modified="2018-07-18" version="1">MGSMINEMPMSSDGYSSLDDDGEDDSDDEASASDDAPGPRTVFSASSQQRPFQGRNQMAPATRRHGPGGLNMFAPNHATDHDEALRASLSTLLSCAAAARGLTKSPPQSQAPGQVQTASQQSGRVAVEGIRVVREGNLPSEASGSVNGSRRGSMVSAEDSTSSPPPSPTNQLSSGNTEKTRKKTRRSDKKCKSRPRSRSSRPQETESSDFTSALGISYATLAISAGAIVLLSAITFSAGYAMGREVGKSEGGLWGRITGGGSEKGKAVVRGLSRASGGGLRGATTGRGILMGGGIGSVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5B9</accession>
    <name>A0A2T7A5B9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1061452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5B9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="25305" checksum="34731C0E21CED8F9" modified="2018-07-18" version="1">MVELVVEDNVSDSEMLSKLEDMEVESEELDGEYEEYEMEIGEPEMEYLLLQKVKEEPDMRRDAREDYSKEQIVFHSIDATTKFHHLAARIMKLNHQGKVKAPLVGNFEATLYIYKANKEQKGIEELFIATFLPLLMNEAKVPTGFGISLKDLFGGHMPNKQDAEHVVWFDFKRSEKFVSETEKCRVNAHVVKWLMACGYWEEWETWVQGKRTCLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5K8</accession>
    <name>A0A2T7A5K8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU82990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5K8"/>
    <dbReference type="STRING" id="42251.A0A2T7A5K8"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015587821" description="Chitin-binding type-4 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="32786" checksum="1CB60762CF5501EF" modified="2018-07-18" version="1">MVSPTIPFVILLALLCVAVPAAAHMCMTDPPPLRYKTNPYKTVVDYDYINPLYANGSNYPCKGYQKDLGTPSAQSVATWSPGRSYSFQLTGSATHSGGSCQTSLSFNGGNTWTLIKSWIGGCVKPDPGSNQTFEFMLPSNVPGGDALFAWTWFNNQGNREMYMNCAVVTISGAKKLATSCASGSSIFVANIGNGCTTVDGKDVAFPNPGSQVEYDGLEANRAAPLGSCGSGSGSMGNERCMGDNGSTSSTSSTSPTSLTSPATTTRPGSGGSTASCERLRSQGHLCSRAAGRGEELQGAILLMVIVTLVNWCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5P0</accession>
    <name>A0A2T7A5P0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1119961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 6">Cytoplasmic vesicle</location>
            <location evidence="5 6">COPI-coated vesicle membrane</location>
            <topology evidence="5 6">Peripheral membrane protein</topology>
            <orientation evidence="5 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 6">Golgi apparatus membrane</location>
            <topology evidence="5 6">Peripheral membrane protein</topology>
            <orientation evidence="5 6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5P0"/>
    <dbReference type="STRING" id="42251.A0A2T7A5P0"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="31387" checksum="D45ED7AB19107841" modified="2018-07-18" version="1">MSINYLSVFACSGFVEEDERSNILQDIDSLHLFAQVVSSICKSLDQREILKHSFELLSAFDEVVCLGYRENLGLQQVKAFLEMESQEEKIQEIISRNKEFEATEERKRKAKQLDLQQRSGGSHSSHFPTYTPPPKPAVADSYDTCEKKTFSSEPKGKGMQLGRKSKTTEMFDQVRNELSSEAEERAPLVQGQEAVASPRQSFSGDRKAIQVIVSKQISAELSRDGGMKSFEVKGGLQLKILDQTLSKVKLDISANTSDAQFRTHPMENASLSPSDAGPEKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A671</accession>
    <name>A0A2T7A671_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A671"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="12263" checksum="E994B52A7CB48EF2" modified="2018-07-18" version="1">MVVKCNVLANLRALADLGFLGLGLDAPELCHSQIPPTTGRRKVAPSGRSEPRLSAIETGRVLSPLLSASVGSLSREWTIFYVFWIIGTVIAVWFTHSLSPKRLDQTGSASASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6I0</accession>
    <name>A0A2T7A6I0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_965031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6I0"/>
    <dbReference type="STRING" id="42251.A0A2T7A6I0"/>
    <dbReference type="OrthoDB" id="5383703at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein cut12" evidence="3">
        <location>
            <begin position="246"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="472"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="794"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="860" mass="95938" checksum="B0739D2F3379C51F" modified="2018-07-18" version="1">MIPPQTPPAIFALKAFRTTLFGTPAPPKFDEKPPHKKKTSKPNPQPVKEKDEVISKALPLHPRRNSEPLDKTEGLEASSDPVVQPIPFKITRKPNLFDPSSIATSELPPNLANSTPVKRPVSPTKGILMTPGTAMTRKKAVTFHPSVPTATTPPNRNGHIRSGLPHEFPGKFPSPWTPKVSTASHHQRSASWSDPGSSRLPDDDEQPGPAEKTEKGKQPQKSTAPILAGYYEVNEDSRIGDFLDESEGDEDIPEELLEVDATMDMEAPRSNSGKYWKERTEKIEGLALSKVDRLKTRYKIATGYAKQKDELCVNLGEKVREVTEKNRRLKGELKRLSTSISGAPSTATGYTNAFSSSSSYNTHVLEQALQRLGEKDAELAASKQERERMEGVIEMHKERLQAFEEMLDQRESKITELSMSMFNGDDDQDLEGVVADLKKKLRCAKLEAKEYGLVRLEAKNLRERVDGLERGYLDVTTEKDKLQRELDRMRAIEEEGDKSMNRIRSNTENRLRAQVEGLEKARKDLRAELREKSLNEAKEKRESERKWRAELAEAKGKTAAAEWEKERFDKEIGDLREYTGRLERELERMRAELDELRKSSGPPSSTAGDDMREWQMKQRTTTQELRKVKEENYSLKTQKSGADDQLRDAKKEIERLRLQLNGATKIDVTALPTTSSRENKEPESASDDSAVDRSFDRRNRPTTSPPPAPSTPRSRSPVKFNSPSPKLPTFSFAEIPKQTNKPLNLDAESSLLLPDLPPDTPVADNNEYTNFQQQRKQKASPRASIVNIAPTPPSSGSSRKVTGVGKVVGRRVSSGAGAIGGGVRRVSSLAMDPARRAAAEKRLAERKRMRGATAAAGNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6L8</accession>
    <name>A0A2T7A6L8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6L8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="115" mass="12862" checksum="2D0EDDA18FF92173" modified="2018-07-18" version="1">MPPSSFNNNEHIPPVRETSSHLRTWIFDAETSDDDDSYFSFPNRPSTTSTTSTKSISTMSIPIHISKDITPETPVSDLGPTPATPDADSPPLRTEVDIVLCYKIRALKHFAHWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6U3</accession>
    <name>A0A2T7A6U3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1060940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A6U3"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="1180"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1354"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="475"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="529"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="703"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="866"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="940"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1527"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="547"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="900"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU83457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1660" mass="180718" checksum="D24D3EAE3D9BBD3D" modified="2018-07-18" version="1">MESPETCLTNVFKIENLSRIPYTLYRNPPPSTPFSIRHAERTLRSEGHIVLGDRESNALWVFQVECFSNGAPRGHGGEGEGGEGRVEGEVQAQIAEESTEGKWKSLERRIREEWGLTESSSGVFLAASLASSTKGGGDIFSPIQLGRSTPVTPAVPTSRPGIFSPSPQDVATIDLTDDPPGEPKEDHLLPYKQFLAAVLSSISFNLSLHNGYTALNIRTLVSPSSLVPHVTESKEDKGDLLPSAPITLPGLLRPSILALEAYLTTSGTFLVTPHTHVQAALRRVSSSLSSSLDKRDVFIAPWGEWGRLVSEEGLKIGAREERWKTSVREYLQDCGILSAPSRQWEEKSILEEAIDGGRWRRVEIWVPIKDHPSEGMGMLVKILWPDTLLFLRTSEGDTDRLRSGDEGCDAFWKKVFDAPEYARFASGRLSRSLAVGVKDKRELGAEWWDIPSAVDWAEEWMDGKDDREKIVMARREEKKRQQQEQERIKREAEAEKEQQSKADEPIPEVKEDGSVKGKLKLLDEAKKDGLATGGNAGVYPTPPDGGQQQQQQQQQPQQQQQQQLPEPSSISSGSSAPNTTSNTTSATAATDMDLDWIDGVMPDAVPDPTRKQSDATGGVGLAGGTGEADLFGGDMDEDMFGGGVTEDDFAFFDNPGQLEGFGGGGDVDMGLDVDFGGGGTVDLAMESPEVTLKEDMLTLVNTPGMPTQNMDQSAEESKTAEPSASDKTEPHIQTPPLSPHRAIRLLVPEYASNPTNSSQHLTPPTTVSAMKTPQKNGGLAPLSGGVNEAKRRMSLYSPITFTTKVEMADRKYAPGGRFFLPESIKEKEQKELEKEQNITTIGLKRKRGGSMFMRSMVVEEATAPEMAEVVLGDEDAVMDDSDGATGEGDDESELYSGDETSSESDADDETDEEEEEPGGGAYYTSPVAVAYGGGIARRKRKRAYEDEDQEMELAPPIPDPTKRDVGVGADEEVGVSGELAPPPWEVMVPDLTESDLVGIFSNISLETEAISLAGLGDNEFATVSRLVRDQIVYGTTKPLGDLMEMTSVETTGEDDDEEWCAIRQRRGKDEGVVEDAVKSLFGKTGVARCTLETYVAIADAVIEPPPLLGRAAAMRPMPQSRRGGIASALAKRPEVEVNTAVFKLPPPHVHIHRAESALEILPPALHFWETFGFGPCSGAKNVIAFCLHPDSRLMEEAADAFLERVSGAYESGRYGVHIRAKLDGVVENGGYGVKGRDIKAVIEAMEDFGSVLANVADEGCNIVVYVVNPFEHPSTLVDICVGFSKLKKVYESRLGGIKGNNLVLQVVRAGFLARKMGAVGTAQAEWARLAAEVYNRCVPSDGVSSLEEAQKIFSPSIYLSRPPPKSIEFKLTTEPSPALLLENSVLHIAYSQSLDERWVSVAWTDNWGTIQSTELYSLGRKNTTILRPFDEVCRDIWNKTLEITSTRKVHWRLVLIKVGEPLQDEINTWTTLASTTTHSLAILSADLNPPVYLIPSLPAPIPTAFNHQVSVYTTPPVTTPTPGSIVSPDQFGNAANTPSADPTPDLDPDSYLVDVCDETWGVILPHRRRLPPDYASGAMAYLIKRGGINDGDELRVLKIELIVAENRGGTIPLLKEVLGWYRDLACLALWKGVVGDGKGNGAPWHLAVAWKAVEGVGWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A728</accession>
    <name>A0A2T7A728_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-directed RNA polymerase I subunit RPA34.5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1112320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A728"/>
    <dbReference type="STRING" id="42251.A0A2T7A728"/>
    <dbReference type="OrthoDB" id="76224at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013240">
        <property type="entry name" value="DNA-dir_RNA_pol1_su_RPA34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053263">
        <property type="entry name" value="Euk_RPA34_RNAP_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155">
        <property type="entry name" value="ACR243WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28155:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA34.5-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08208">
        <property type="entry name" value="RNA_polI_A34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="278" mass="30305" checksum="AEA5DCA32C043817" modified="2018-07-18" version="1">MASSANTAKKRLTKSTPTPTKQKEKQGKAKPRSMQKVTVSDAEGDSTSAGSSESSSVSESTSDSEEEDEDEDEDEEGEEEEEEEEETPVIPPPTDFLRLPSPPSSSGNPFSPKNLAGKELWLISAPSSAPLSKLRSVNAADVLDNAQVLGTSSGRRFSVRETDEGAGVQVLVPDGRGGYLLGGRSITKSVQFFETLPDRKALEKRRERVVAKSVRAQPDGLKMRFKPMGYVGDQDEDGMPDAVEPEISEPVRKKKRREGGEEEGERKHKSKNKKEILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8A0</accession>
    <name>A0A2T7A8A0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1071184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8A0"/>
    <dbReference type="STRING" id="42251.A0A2T7A8A0"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="23301" checksum="AFEE5A1B2121C928" modified="2018-07-18" version="1">MWGWFGGGAAKKKDTAKDAILKLREQLEMLQKKEKHLEGEIAEQDAISRKMVQINKSAAMTALRRKKIHETHLASTVAQINTIEQQMHSIETANLNFETLKVMQSASDAMKKIHNGMNLDKVDMTMEEIREQQQIAEEIGSAIANLSEPADDSELLKELENIKQEQLDTQMLSAPSAPITSTPQAIKGKAIEEDEDAELMKLRAEMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8E5</accession>
    <name>A0A2T7A8E5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_651965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8E5"/>
    <dbReference type="OrthoDB" id="10361631at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="341" mass="36528" checksum="E249CEF31C16562C" modified="2018-07-18" version="1">MRDDTESTAPFTYPHCDSPSSDQPASPTFKHSLVPLEPLWANDFPHGLTPPPESLDPGELYLDYQNSIHSAGQPAPNSTHSFETPSIRQPPTPPRAEPSPTLHKSPSGLSGGSQESDGPSPGSSIPTPEAILPEGDVKMMDIELDGAADAKDGPEIDFMGFSDEMATQGFGEGGQQLGKTMTEFFDFESAASSPLNTTSQLVSPDPNPKFQPRSLHGSLSPQPQPFQHTFSAGAQSITNWCAGMRYAGDSGLDNSNGVTPARPSLSRVSGRKRALAGESFDNSQDTSDEGSRPANISPPAQLVQLQDRLILQILGISGFLSKLEFHLNLFSLSEYSRFSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8F6</accession>
    <name>A0A2T7A8F6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-phosphofructo-2-kinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1060585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8F6"/>
    <dbReference type="STRING" id="42251.A0A2T7A8F6"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="263"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="703" mass="78326" checksum="D7E6842E3F68C392" modified="2018-07-18" version="1">MAPSVQSSPQVTNPRSPKMMSRCPRSPRIVSAFLSPVPLPASNAPQNMLPLDNAFNGGPQQPPQSTSPHPLKQTQHSSIAKSVMSTPGMARTNSAGKEGIQLLSPPNQLSAGQALTDTPATTAPNSPRIRATTLDIPGLTKSRVSPDGRIACRDIGAKLVIVMVGLPARGKSYITQKVARYLNWLQHDTKIFNVGHRRRIAAGAHDNLANDEPPHPSVKHAGPATPATLLHGTSPKSLSSLVNSNSRPGGHRRTDSVTSIDIDGGVDQSATFFDPANKAAAELREKVAMETLDELLDYILNRGGSVGILDATNSTLERRKAVVDRVREVAGKELGVLFLESECHDQQLLEANMRLKLSGPDYKGQDPVKALEDFKKRVEIYEKNYVPLGEYEEKAGMQFIKMIDVGRKIVTHQTKGFLAAQTVYFLLNFNLAHRQIWITRHGESLDNVAGKIGGNASLSENGEKYAKTLAQFMDVERKKFREKQLHKHECSHMPPRPGDTTPPNPEYSNCCTQDEEGRPLEKNFCVWTSMLARSIETAQFFDDEEYDVKEMRMLNELNAGVAEGLTYDEIKHQYPKEYDLRRDDKLHYRYPGAGGESYLDVINRLRAVIVEVERMTDHVLLIGHRVVARVLLAYFLGLEREDVAKLDVPLGTIYVLEPKPYGVEFRAYKYNSETEWFDFQPDFKLKNEEQKDIKVNVKVAKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A926</accession>
    <name>A0A2T7A926_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1118105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A926"/>
    <dbReference type="STRING" id="42251.A0A2T7A926"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7881" evidence="3">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="115"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="252" mass="28369" checksum="D6CCA98E0B5A15C9" modified="2018-07-18" version="1">MNYNRSLGRDIHIYSAKEPDLVLGGLILASGMTNTNFYAMVEIVFIFTTNFTLRHRSGVVITRDDGPIQPGDYFIVSAGTCATNNEALISSLEAIHPGARDGNFRTSVRDRDRRCVITETPVNERQVECGFRSGINACHIFPIAHNWLWENKNYGRWVKDNIDDESEPSGSINSVRNGILLRSDVHDWFNNYTLSIDPDDGYKIVAFNFDSRFGRSGARLNQAYVQSPDAPSKHLLRLHYRQAVLVNVRGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9B0</accession>
    <name>A0A2T7A9B0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9B0"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="380" mass="42804" checksum="EF81C84187234765" modified="2018-07-18" version="1">MFAVGESSFTRNSWIASVRTPRYLNTEECIHRFREWRSGRGGLNPPKNNEKGLILKVSVQNFKTFKKFLGIDDENESGKFPTYTYNRALSTLTIQCSPSSIHEKAVTTISKGFTFAFGTLPVNTQDKIDTVTNEKYDNFKGKYAGSEKIADLAVQVENDTGVREAKFIVEIGLSESYQKLVQDAELWLKGTETVKIVMLVKLHENPPYRCPTHNRSDEEFDALKFPSKEDINEQCFSISGEYGPATYKDLVWVGEISGYIEFWGLDEISKLACVKGDRIDLLSADKPNKTMDKYLSMSNFVPGMHHPIHFNSHWAAYLRSLKHYIGQLAASRCRTTLKDRYGRTNTTDYEFMPPSPVNSLSGSSSFSTPSPNSPSSANSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA89</accession>
    <name>A0A2T6ZA89_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1004372</name>
        <name evidence="1" type="ORF">B9Z19DRAFT_1010186</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000546">
        <property type="protein sequence ID" value="PUU72408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000372">
        <property type="protein sequence ID" value="PUU73500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA89"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA89"/>
    <dbReference type="OrthoDB" id="4354629at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="220" mass="25069" checksum="C1C329920AAF29EE" modified="2018-07-18" version="1" fragment="single">MGYSEHLSKELCSKLFCGVGLQSDNLPIPGLSISNSSETFPVNCSYDIDSFISKAKSLSIAKKGIRVQFCPNSLQNISQNIHLFSPIPERLISGKIKYHQIPIHHIPHFRLGTILSTLHIPVYVFLPGLYQQSPTPNSYINNHTLQQWMDIGFLPAVHTHYTDDVLQHLPTSFDSAYMEVYARSRESGIKRSSNDPQLGRRQEIHYFLPSEQLENVWQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAB9</accession>
    <name>A0A2T6ZAB9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mis6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1009964</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000536">
        <property type="protein sequence ID" value="PUU72438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAB9"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="720" mass="80402" checksum="CA1823A52D04A236" modified="2018-07-18" version="1" fragment="single">IRSHNAACLLYLAASIRNSLSKNRIAGVIDSVSQHATIRGLTNDSLEGLIGILATSPCYLDQPSVGSIVKVLFPRGKVSENIVVMVIGSLGQGESKPSHATQALLLRWLVMVYDVLDSYDVLSRLYGVLFNLLDMITGHLCHILSLLTRRKHVRPFRIQTLYVLLLTLKQNLGNERPLLGLLQVYKDYYPDVIVGEITAVRAGVFSHPDIEWVQKLLLIQESNTGDYSGPSDSQSSFRIARKIGGQAMKRQKTNHIVIPKVHTLRATEASVTLEEVEDVSDFVKKLDKLEMPNQLVAVLEDPLLRKLTSLKPSDGTNLRINNWLAACLSSEFHSPSVSNLRSTDRTEQFLSRVLEYTRSTRRLLPAVEDFLKNYLQTWGGDSHTTTLLGLLCFLPIQEFEELHSNFFALVDRQLKRRGEASITKLVAFYTELIRQWSITYGNQAQEIEFSQEESLALCKVLSHVGQICLVGLSNFPESNLIADAILCFYEGTCAPPWENGLFRIVLPPDQVVYYFVFSGDVMTLSRICGILSRYKRGFELSLRQAQSGHSNGAGEYPRDYVNHFNGFLMDICNLVWRNRAFKWGGSDSKQDQNALGCTLTNNVILCLQRAVDAREESLLTLFSLSHSAVLAQFSAECFRMLENVNDSEMNRIRHAGPVTQKSLQLLATNGGLKITYSDFRVAVLRALGGKGLGGIWDFMHSTMISLIQLTSGADSSRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAJ3</accession>
    <name>A0A2T6ZAJ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1097127</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000517">
        <property type="protein sequence ID" value="PUU72508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAJ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAJ3"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="208"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU72508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="347" mass="39764" checksum="C5D52D971E2079C7" modified="2018-07-18" version="1">MSTKELSTPPVATAGAPPTEEQRTRAEVNRLKAIAIREALKEQAESESTIARPASNNTASSSSSLAPGNKRSFATMASNRTGGKGREDIAIKPARKFQKFVEYEFAKMKDTKGGFISTEDDPHSMLSAVDLQDKPAHMSLEDWAKHQLKMKLIKEKSGPYEPGLSALTMGEKEQIRCYECSSVEIDWKWYEIFKCRVCAGCKDKMPEKYSLLTKTECRNDYFLTDPELKDEELLPRIHKPNPHRSTWNNMMLYLRYQVEGFALKKWGSMENLDKEFERRNGVRKKRKDDKFRAKLKSLKNKTRVESWKRSTDNEKHEHIWGTAVTNASGESVRTCEECGFEIEELVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAX1</accession>
    <name>A0A2T6ZAX1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1008956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000495">
        <property type="protein sequence ID" value="PUU72623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAX1"/>
    <dbReference type="OrthoDB" id="10456725at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="12276" checksum="E56D00B9D80FDE63" modified="2018-07-18" version="1">MIVAGVVVVVVVGGMIAVVGLVEGQGVEVGVEVGEVGILEIPYSQVVPLRLSIRISRRWRTNSSLLKRGSMNRLCLPVPISGRKGFRPWSERIIFQWLYPHRRFSSMMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB34</accession>
    <name>A0A2T6ZB34_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1008838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000491">
        <property type="protein sequence ID" value="PUU72656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB34"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB34"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="8934" checksum="5B24721690BBBB26" modified="2018-07-18" version="1" fragment="single">LTQVDGKGRTVTAAEAYQIECHASSMIRAAEDLLALTRSLKEAWMFGQLGGELGVVDEATDQNAKEVGEALQKLATKEVGGLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB52</accession>
    <name>A0A2T6ZB52_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_636335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="NESQ01000480">
        <property type="protein sequence ID" value="PUU72699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB52"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB52"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015581780" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU72699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="323" mass="34392" checksum="D0FAA32E8B53B6C1" modified="2018-07-18" version="1">MMFLKSLLLLVSFASTAISYQNPGACSGACNVHDPAVIRRTSDGTYFRFSTGNKIQIATSSSLSGPWTIKGSALSGGSKINLAGNQDLWAPDVTKVGDTYYLYYSVSTFGSQESAIGVATSTTMEVGTWTDRGSTGVISHAGSAYNAIDGNVVLAGDGSYYMSFGSFWRDIYNVPMNNPPLTISGSSTRLAYNSTGSHAIEGSFIWYRSPYYYLFFSAGVCCGYDSNRPAQGMEYRINVCRSTSVNSGYVDKNGVACTASGGSTVLASHGNVYGPGGQGVFLDNEAGGAVLYYHYVDTTIGYGDGQKRFGWNLISWGTGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBL9</accession>
    <name>A0A2T6ZBL9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000447">
        <property type="protein sequence ID" value="PUU72892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBL9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="139" mass="16260" checksum="C6438DB7DA985935" modified="2018-07-18" version="1">MSFSKFLTRSTTSVRTDTFRHPANRMCTAINRCLRPAINHAQQRGGLPITMLRHSPSLMRYEAKSLKHSREQHAGFREQEAIRSREQQAVSFQHFENQPNCYREQQAQSREQETLGSQKQQVTLRSQKQLARSLERFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBN7</accession>
    <name>A0A2T6ZBN7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1136429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000446">
        <property type="protein sequence ID" value="PUU72908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBN7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBN7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="194" mass="22577" checksum="D1C2F254BC16650C" modified="2018-07-18" version="1">MRDRGVELSTSSWSACRSSENFHNPDEFKSERWLDRNSTDKKHTSQPLSLGSRVCIGRNLALKEIRLVLSKMLWVYDMELVNEDLDLDRDSTTYFLWIKPEIWMRFTRRQGVQVLLELAQKRSESKHKVMGPMNKRKKEIDVILLVLPIDAPETGVLIAVRSMNIHQYDSSHFLVPHVPSSLATGRTYLYCMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC22</accession>
    <name>A0A2T6ZC22_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000421">
        <property type="protein sequence ID" value="PUU73047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC22"/>
    <dbReference type="OrthoDB" id="5465007at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="234" mass="26690" checksum="7B53ACBC715035F4" modified="2018-07-18" version="1">MYKSTLCNPTPTNPHSTESDIKLLSSFSSQQIDSLHIPQNRVEIEQQELIALATLTKNNSIEWGLKRIVSNLALADIQHKRGVNRTRIPTSGKAWVDHEDIARFFESQSIEERKATQMKYHHATNLVTVRCKKLAECTHKRKETEDLEEEGKLPKHRKPSATLREEETRLTKLILEAQQKVEKFEKHLQDLASDMVGESQGLEGENFVGSPEEEITSEFDEEQEENLEEGAGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCC2</accession>
    <name>A0A2T6ZCC2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000409">
        <property type="protein sequence ID" value="PUU73147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCC2"/>
    <dbReference type="OrthoDB" id="5479211at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="25683" checksum="DB2362BB2038FFD3" modified="2018-07-18" version="1">MATVRTTKLPKHIAEIGMTAEQYFELKVHIKSIILPGTPAFESKRIDSKDPVYRQWLINALREIGPRFFSRGGNGLVWPEERAGISRAVHQVIRALGAKIKLNYKLELGVAGNGTGDGVEMARDNEHYEGGDADDTDPEEDIVMADEKVLPEDQENGVMIMIDQNDQAEKRMEEEMEAAAIELEDLLALMQPEAFAQFPDFDDDYFDWDELMDSNTSDGVRHLANLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCZ3</accession>
    <name>A0A2T6ZCZ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1004678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000382">
        <property type="protein sequence ID" value="PUU73371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCZ3"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="219" mass="25192" checksum="BCD8DAC4D7703FDA" modified="2018-07-18" version="1">MTLQRLRPITHLRIIDSKCPTYPRAHFSIVCPRLIQHPAPSKARFLPRILDPAVWFPFYKTETKKRKASSKEKNPKIHNPATFFVIMAMLIGSQGIQMIRIRQTHDDYMWRADTKIAVLREVIERLEKGEDVDVEKMLGVGNEKEEKSWEEVLKQLEEEDAEWAAKRNQKAQPAPSVGGSDNTVAETSKSEERTGENKRPKEEPAKPRGPRSARDYGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD14</accession>
    <name>A0A2T6ZD14_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000380">
        <property type="protein sequence ID" value="PUU73387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD14"/>
    <dbReference type="OrthoDB" id="5470099at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="12928" checksum="558C14933EE52565" modified="2018-07-18" version="1">MPTRGGCPPSTAGFTPMPYNPGPKPPSSNQFLRAPQKSAPPPTAVQEQAVVELNELSQMVCMEHYHRSTPLDLILSGRTEGYSVQWQYKMLFWNLKVCADCGFRRIKCSKSVEIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD73</accession>
    <name>A0A2T6ZD73_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000377">
        <property type="protein sequence ID" value="PUU73423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD73"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD73"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35117" checksum="865BB1BC3E35D7AF" modified="2018-07-18" version="1">MGRPDIASRFRGKVVQLETVEGTTLYVHADILDSGRGICPDVPWDSFKTSTVERFLEYCYQGDYSFPKPVKVPLATPTSSIDDYDEYADSVCHPRPDYLRGCRCVNYRVTPRDYSDLSDSTTKDDDTEDAVSEYESGRDDDGIEYDEVTDTEDDDQDDSGLSGHPNGLDYGAVFLAHAELYILSQNQGRSSLTLLCLNRLRKALDQAAKAPVRPRFANNLSDLLLYTYEHANLSLADDQKADDLQNMVSSFAAIHIKEMKEEFGSLMRCGGKMAEDLMKEVVDRVISLEGVSKERTKSRQFTRGDLGGVNIPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDB4</accession>
    <name>A0A2T6ZDB4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_539554</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000373">
        <property type="protein sequence ID" value="PUU73488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDB4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDB4"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120718" checksum="F71A4A7D3E8C4CEA" modified="2018-07-18" version="1">MDEHNFIQLLEHVLTPDTNIVKHATGTLRRDYYSKPESLSVLIHLLRTYPNPQIRQLAAVEARNLVPKFWPAKDDGSLIPAELKSWLRESILQSTIEETNSLVKHSSARVISSMAKIDLPAGEWTDLPGFLVQAASSDRAENREVGIYILFTLIESLEEVVADKWHEFLPLFSRTIDDQGSMAVRLNTLLALGKMAESLNSEKHPGGVAAFKEVLPSMVAVLKELIDAADEEKANSAFEVFQTLLIVDSALISSHFRDLVQFFSDLASSTNVDDDFRSKAMSFLISCLRYKKMKMQALKFGEQLTLRALQIVTEFKDLEDTDETTPARSALGLLDYLSASLPPSQVVVPLLNILPQYTASQDPEYRKAAVLALGMCVEGAPDFIATQISSIFPVVLQLLSDPEARVRQAALHTVAQLADDLAEDMGKEHSRLIPALIRLLDSRDGSDTWKAACNAIDAVLVGIDKKDVETYLPTLMPRLSEMFQRDDLKLKAAAVGGIGSTAHAAKDSFSPYFQAAMGALFPYISVKDSEDELDLRGVVVDAMGNIAEAVGMQAFTPYVEPLMQSAMEALNLGHPRLRETSFMFFSIMARVYREEFTPFLPNVTQALFQSLEQTETDIDVEIGELAKDAIITSVGAVGTQKASLGGDIQAEIQPTDIDVDDEDDDALWDELNAVNAVALEKEVAAEVIGEVLSHCKEGYLQYLEKTVELLALKAQHPYEGVRKASISTLWRAYSTLWRVMQDKGMAKWLPGLPLKAQPPPELVRLGNLVINCTLANWSIETDRASVTDICVNVAETLSLCGPAFLVDTNGTIMLELASQLVLILKKQHPSQLDEEDEELPELHESSEYDWILVDSAMDVVLGLSKALGTQFGEIWKLVGTLLIKYASSSEAVERSTSVGVIADCIKYMEEGCTPHTSQLMKTLLHRLSDEDQDTKSCAAYALGMLCIKSQAAQEVTSNYGAILQKLEPFLQVQNHRMLDNACGCISRMIMAHPDSVPLGDVLPALAGLLPLKEDYEENEPIYKMLVQLYKNSNQTAFGMTQQFLPIIAAVLSPPEEQLTLETRKELIELVQFLFKTEPSVLRGYDNLILLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDC6</accession>
    <name>A0A2T6ZDC6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1094970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000373">
        <property type="protein sequence ID" value="PUU73479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDC6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="8729" checksum="02FD75302EC3BA19" modified="2018-07-18" version="1">MQSPSSRLLFHLPHVALITKALLGCLLLKIRLIENFIILWYHTTVARAVSSKRLREEDKILGPGLFGRGCGWLGGVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDE5</accession>
    <name>A0A2T6ZDE5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1004265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000370">
        <property type="protein sequence ID" value="PUU73515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDE5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDE5"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000217">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="4">
        <location>
            <begin position="466"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="3">
        <location>
            <begin position="934"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="953"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1262" mass="139599" checksum="7507E2448EC74F76" modified="2018-07-18" version="1">MVFKPFTTLARQSISKHLVNGYAQSVVAATQSSYASSTVQLSRLGQQNAPARLHTAFGGANSGRAAPGKDGQGGDSLGAYYAVQSQAVDEKEEKENRKYLFSRKILWSKAQRQQQQKALLEELDLPRSRSSSLAQVEAQLPSMDVVKGAKESEEEAVFVEPAAEESEVLLSEKVAPVEEVEVEVAPSPTSSEETLVPALPEVSSITAQYNNQLRDLRTAGKYEEISALFEHMIQEGVQPSTTTYNHVLVALVQTGAGGIARVLNVYQDMLRNKVLPSTVTYSILIDYLAASSKSSLQFARQIEDDILRFGFVVPSRKRELDEIRSQKSLDMALDIFYASTEVRVERTFSEPVYSILIEACAESSREEDMLKVYTHMEMHGVSPSLDTTLSLIKGFGKAGNIRSAVETYNNYCALDTSKKPGSVDERYLVYKSLILAYMEAGDPAGALSFLEKIVSTSKDAHRSQWLAEAIIKGFLQRGDLESAKEWIVGRMTGTSEYLGLSKALIGVADLGDYELANQLYSEFMTHVRLHGINHSSTSIAQMAFLNLCVKEGKIENARAVWNDLSERILSNGPDAEAAIVYSMMLFENRLTNEALVVLKQFSEFFMEKPSSVSLALRAEYLREAFESSIDRLAAKDLLTHGVALDISGFGMRHCGCMGARASKIVLGLFGEQRILGLTLPQLDLLLQVQAGVLQQPGEPASEGMQKFEQMLTLALNAGVSLSKALKVSVDGVIAARGINEGLLAKWTAFAQAQKVWENMPMAPLTEDVVASPTLAPSEGETAIAEDNYDPYWAKTDVKVSQAIDNALEGAKTARARLMDARRMYQQTRKAGRLVRMTTLARMVGAAARAGQPEFMEEIYRNARTDAPLLVEFRSVRYVWCVLLDSMVAGHLSVGNRQQAAVYHEEMLKMGASPSANTYGLYIVSLKGSNQTYDEASEALKIFERAKAENVLPSSFLYNALIGKLAKARRVDDCLFYFAEMRALGIKPTSVTYGTMINALTRVGDEHFAEELFQEMEAMPNYKPRPAPYNSLMQFFVNTKRDRSKVMSYFNRMTSLGIEATSHTYKLLIEAYATLDPPDMPAAEGVLDLIRAKNQPVESSHHAALIHAKGCVLQDVEAAISHFKSLLHPTTSTTKPQPQLDNTIYQALFESLVANHRVQDTTLWLSDMERRGVRMTPYIANTLIHGWALEKDIEKAEGVYESLSKDENARLKREPSTYEAMTRAYLAVEDRAGALRVVNEMSGRGYPNAVMVRVMDLVRGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDJ0</accession>
    <name>A0A2T6ZDJ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000368">
        <property type="protein sequence ID" value="PUU73568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDJ0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="102" mass="11627" checksum="BAC4872EB83ACF65" modified="2018-07-18" version="1">MASVSEEKLKPSQVGKVDIRENPKGKGSKKAKEASKPFRSSKRSVHPSRAGEARKKKKIMEQEDREMPEEIRKLPGIVEFSTYMKKEIPDHPREARATSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE45</accession>
    <name>A0A2T6ZE45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE45"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9621" checksum="2AC778CD83668EF0" modified="2018-07-18" version="1">MDSMTYKRKIENKEAYFSDNQSKISPEPPPLSPSSAGMKGRVDAFQPTNRPCPSKKSYNLSAPSTNPNTVIISTDNGDLSSDEDINPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE66</accession>
    <name>A0A2T6ZE66_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Chitin synthase</fullName>
            <ecNumber evidence="2 8">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1003144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE66"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="692" mass="78207" checksum="CE5A2364BB03B2E6" modified="2018-07-18" version="1">MYNEDEMNFTRTMHGVMRNIAHFCSRSKSRVWGKDGWQKIVVCIVADGRKKVHPRVLDALAAMGVYQAGIAKNSVNGREVKAHVYEYTTQVSLDSDLKFKGAEKGIVPVQMIFCLKEQNAKKLNSHRWFFNAFGATLNPNVCILLDVGTRPGHDSLYHLWKAFDTDSNVGGACGEIKAMKGKGWMGLFNPLVASQNFEYKMSNILDKPLESVFGYITVLPGALSAYRYHALQNDESGHGPLSQYFKGETLRGKDADVFTANMYLAEDRILCWELVAKKNERWVLKYVRSATGETDVPDAVPEFVSQRRRWLNGAFFAAIFSLAHFKQIWVTDHTYIRKVLLHIEFIYQFFSLLFTFFSLANFYLTFYFIAGSLSDPKMDPFGKGWGGRIFTILRFMCVLLICTQFILCMGNRPQGAKRMFMSSMIAYSVIMAYTTFCSFYIVIKSFSGGFGGQKTEIKIGDNIFTNLIVSTGSTIGVYFLMSFLYFDPWHMFTSALQYFMMLPSYICTLQVYAFCNTHDVSWGTKGDNAVSVDLGAAVGSKGDTVELEMPSEQLDIDSGYDDALRNLRDRLEVPVEPMTEGQIKEDYYRAVRTYVVVVWMVANAILAMTVTEVYGLTGIGGNFYLKILLWSVAALAVFRALGSSAYLVLQAIHSFVEGRMKLDPKTFTDTFQPPWKRKLRLTGVSQSNLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE68</accession>
    <name>A0A2T6ZE68_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_509662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE68"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="16786" checksum="8C790845A80A2F7E" modified="2018-07-18" version="1">MGLFECNPQKGGQKIRIREEKEEEMGTITYRMHTDDTKKVMSKTKVVMRPMVDTMVGGVKTGERPQYGTGDTAAKARLLKQKTSQWESQREGSKKALQGKCQRQQKLAQQHPKTRGTTSGKGKVKDQTEGRERETRKNAPITGQVHAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE69</accession>
    <name>A0A2T6ZE69_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000352">
        <property type="protein sequence ID" value="PUU73694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE69"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE69"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="131" mass="14603" checksum="FF0185A313F8589E" modified="2018-07-18" version="1">MGIKVSLMGTEISKILGTPVVDKPAPRQTASFSSYGNEADPHLCENSIPMELNSSEGREAHDSSSHSDKNGKNTFLRQVASTNAKYYKLASRRLEQGRLETVNRVLKETVSTKSPPRGWRQMATYLFQEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE80</accession>
    <name>A0A2T6ZE80_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery-associated protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMA16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE80"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE80"/>
    <dbReference type="OrthoDB" id="270284at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.170">
        <property type="entry name" value="Translation machinery-associated protein 16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021346">
        <property type="entry name" value="Tma16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038356">
        <property type="entry name" value="Tma16_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13349:SF2">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11176">
        <property type="entry name" value="Tma16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="19520" checksum="C7D348CDC9BC0DA8" modified="2018-07-18" version="1">MPIALAKVAKKIRAKKGGRLDQLSVRHTNKLNRATQREAKLRRLEASRSKTREPELVRVGYFKVATKDTTEPLSIPQTRDLIERWVHRNDEELCELQKARRPGRPPSAKEDSLKQSIAREMEEFRTGFYVPDLQDWANIEWLQRWDGSVGALAQIRFKRIAREDSEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE96</accession>
    <name>A0A2T6ZE96_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Replication factor RFC1 C terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1094332</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE96"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE96"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="247"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="745"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="762" mass="84534" checksum="AAC2B85EF747715F" modified="2018-07-18" version="1">MPADIRSFFTPKGGQQAAGKPKPAPTPTTRKRKTAQLRNEHEDDDDDDDDDDDEIEQAKLTVRSSRPAAKKAKAVPKNSKEAPKESESVRNILDSVQIFRPPSPPPPTDGEPKKFNYRDFKQPQGAAPTAPGSKEIPVGEENCLTGLTFSLAREDGQQLVKKYGGDAGPKKVETIRKLKIKTINEDGLFQLISALPANGGDVKYAPSLLTQICGNKGQVEKLGRWLKNWPKNLKTNFKMRGADGMGGARAVMIHGPPGIGKTTAAHLVAKLEGYDIVDKKLMEEKLRGVLDNRSLLGYFAGDGKNVEHSKQKMVLIMDEVDGMSAGDRGGVGQLAAVCKKTNIPIICICNERKLPKMRPFDMVTYDIPFRRPDATAVRSRIMSIAYREGIKLPPNVIDQLVEGTHADIRQIINMLSTYSTTQSSMTFDQGKDLAKAWEKHVVLKPWDIAQKLLGSEMFAPTSKKTLNDKIELYFNDHEFSYLMRNLKMLELVENASKSISDGDLVDALIHGPQQQWSLMPAHGMFSTVKPASYMYGGFGGQQFGFTSWLGNNSKQGKLSRFVKEIQSHIRLRASGDRHEVRQNYIPAFYNMLAKRLERDGKDAILEVIDTMDDYFLTKDDWDAIIELIVGPASMLDIPTQTKASFTRQYNSMSHPMPFMKSSSVAAPKASKQDAPDLEDVIVESEDEGGDEDAIKKQAEEEQDLSKDKYVKTKKPKADPKGKGKGKAAPKKNQDDDDDDEDDKPKKKPKAASKPRAKAKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEJ2</accession>
    <name>A0A2T6ZEJ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000334">
        <property type="protein sequence ID" value="PUU73910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEJ2"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="20096" checksum="78C07047BB12219D" modified="2018-07-18" version="1" fragment="single">MLPVVDSNSTVLPSPPSNATIVTALASNSAVLPSPPSDSTILPVVDSNSTVLPSPPSDATVLPVIASVSMGIREFQIPLEDIFGNDLPEVLDPKDSIIFSLRELEAHVMGRMSAAREAISAITEEKKLGVHAPPKTKKRRIATPRAIAIFAEDGTDGCEDMNPISIHPPMALSEKQRNQLERDMKDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFT1</accession>
    <name>A0A2T6ZFT1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000305">
        <property type="protein sequence ID" value="PUU74347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFT1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFT1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="218" mass="24457" checksum="70DFC881BD1F98F8" modified="2018-07-18" version="1">MAHIKKEQSVDLTYPQRVLQIGVQAPHNTIPQPARAGKAPALNSEDSIMRVLKDTAEGVAKVVQGQATILRKLEALQDRQDAMLQELPIIQQEQAPLIQTVGRLEEGMRRLEHRLDAIHPEVRGIRPDSPHHITSPSEQNRIARLINRRAKRDNTVLEPFYGFNGQLIPDFPRTLGDTKRLNSLDLTILLLYLGLPASGSFAVRKARFLNYVGLVYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG73</accession>
    <name>A0A2T6ZG73_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptin N terminal region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1133252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG73"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG73"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="737"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="790" mass="86246" checksum="DDE96A58A57FDB28" modified="2018-07-18" version="1">MESLSRISSILETARDLTLEAAQAASASGRTIRKDGKQGTSAETKKLLNSRMDKEVLDGLRMVIGMMSRGVDCSEFFADVVKNVASPTLEIKKLVYIYLLRYAESEPDLALLSINTIQKALNDQNQLVRAMAIRVMSGIRVPVISQIVALGIKRCVADMSAYVRKSAALAIPKCYRLDPTTLPQLTEYLGTLLGDRSFYVVGAAVMAHLEVCPDKWGLVHPHYRSLVKMLIDMDEWGQLALLRLLTEYSRKHFPARRTKKKVKNRDAGGVEDFYSDEEVGGNARGKEVEVATVMDPDLELLLKACVPLTQSRNSAVIVAVARVYRHLAPPDCLPTVAGPLVSLLRAAVDVQHMALVNIVSIALEHPQPFTQFATHFLVHASDPAHIWRLKLEVLTLIFPHTNIHTKNLILSELEYFAKGYDKELVKEAVRAIGRCAQSQTKNAARCLRLLLRQVESSDGTLVAESLTVIRHIIQQDPQNHAKTVVRLAKALDTATNPSARASIVWLVGEFAGINDGNNVAADTLRILAKGFHSESEQAKLQIVLLAAKVYAHHLNCAPPAVPTGENQDDEDKHPISLLFSYILLLARYDLSYDLRDRARLYKSILSVPSSTQLATLLLLAPKPTPQAPSPSSGRESFTLGSAAMVIGKDEDICGYEALPEWTTPSRAPSPSLREPPPSAASGADTHRGGSTTSMSAVVRGAGVRSASPRIGSPHMGSPRAGSPALPPTARANGVPESLEEFLASEEEEEESDEDGDDDDEEEEESEEEESEEEESEEDEEGESAGLLGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG86</accession>
    <name>A0A2T6ZG86_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG86"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="10579" checksum="EDD0351C806D373D" modified="2018-07-18" version="1">MADILSNIPTGSSGSLLLVQKLRASPLFSVSPLITIPGISIVFARNKLYWGKSPRDEHRILKQKFAPLVCAVHCAIAYAFVCGRMRSQSNDFCEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGM5</accession>
    <name>A0A2T6ZGM5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">No apical meristem-associated C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000286">
        <property type="protein sequence ID" value="PUU74635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGM5"/>
    <dbReference type="OrthoDB" id="10450107at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15435" checksum="59C6CD3FFC1F960B" modified="2018-07-18" version="1">MMEEDDSQGDAGTMRGIGGPVRNKKGASTALIDAVSILATAKTQDKERKFNFLSEHLQQQGELRRRELDIERKWLDLEREKTAMEQEKTNLMMRQLEESIRVGISHGKGSKSRKKNIIIDDEEEESNSIFDLENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGY9</accession>
    <name>A0A2T6ZGY9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1103290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000275">
        <property type="protein sequence ID" value="PUU74755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGY9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGY9"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF14">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015407924" evidence="1">
        <location>
            <begin position="26"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="26486" checksum="2F1554E5494DCB5E" modified="2018-07-18" version="1">MSLTAMFSSSAILSVAFELFMLANARPFATGDLNGETVEVSSLGAMAKSSIAVHPGAKISTLEEVLDLIDCYGDKKVQINLETKLDPENPNQTLSVDTYIDNLVPILQRRGYADRTYIQSFDWRTLIGIKKKFPKTRTVALLDDTTVVPSGNLGFTWLGGIDLQKDFAGDWVKAAHSINATALSPVHGVPSSVNTPGYKPFTTAAIVSQAHELGMIVVPWTVDDEVTIDKMFRRVIHTSQGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH56</accession>
    <name>A0A2T6ZH56_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1067926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000272">
        <property type="protein sequence ID" value="PUU74821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH56"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH56"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="242" mass="23670" checksum="30342437A97B5AFA" modified="2018-07-18" version="1">MHFLMRSASPGSTSFGTTSGGTYFLAVSGGSTSVGSTIFCAASRDTTPFSHTTSGGTTFCAASSDSTPYCLTTFGSSFFCAASGDSTLLGPTSFGGTFFSAASGGSTLFSHTTSGGTSFCAASSGTTPFCLTTSGCTIFCAASPGSTPHGPIPSGSTILSAYRAPYNAVSFDSTPFSTASSCGIPFNATSSGGTAFSATSPSSTSFSAAYSCSAAPLGTTLTNTCSSFTTSSGDASFSPCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH72</accession>
    <name>A0A2T6ZH72_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">ATG12-activating enzyme E1 ATG7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-like modifier-activating enzyme atg7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1103255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000269">
        <property type="protein sequence ID" value="PUU74843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH72"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH72"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="12">
        <location>
            <begin position="290"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU74843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="632" mass="71107" checksum="1D855C7662727960" modified="2018-07-18" version="1">MKYAPFSSLIDLQFYYSLASHKIDYDKLDESPRKVLGQYLPHDGGRMQIHGSALTSDEVAITACRAEGMIKNYNTIEDFRRVEKTVMIKRSAQTIWDAILDGSIYSCPSLLSSFLILSYADLKKYKFHHLFAFPAFAATPQWTCKTPIERLDRHQTASLVEAINTWRYNTDSRQHGFFLLKRDEGAWKIGSLGDFEQSFFDKDVDEEDRFVAFVDPSDYPDNPGWPLRNLLMLVRKRWGWRKVRLDEMPKVVGWEKNDDNKIVPKIANLSAQMDPKKQADINVDLNLKLMKWRVAPELDLDAIRNTRCLLLGAGTLGAYVARNLLSWGVHKITFIDSGTVSFSNPVRQPLYTFQDCIGGKTMKAIRAAEALKEIYPGVDAQGFDMTVPMAAHPFSDAQEAGVKQDYLKLRRLFDEHDVIFLLMDTRESRWLPTVMGKSMGKLVMNAALGFDSYVVMRHGVKPSDDQKGGEELGCYYCSDVVAPGDSLSDRTLDQQCTVTRPGVAPIASALLVETLVSVLQHPLGAAAPAPNNDKADRSPSNHPLGLIPHQMRGFLSSFHNIMVKGPAYDCCSACSPAIIKEYKVNEWEFVKKALNQKGYVEEVSGLLEVQRRADEVEMDDSDDDDDDDGDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH76</accession>
    <name>A0A2T6ZH76_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000269">
        <property type="protein sequence ID" value="PUU74841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH76"/>
    <dbReference type="OrthoDB" id="10533816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="321" mass="35304" checksum="C55AD9A2AFE69645" modified="2018-07-18" version="1">MEGRNMEVAKYPDDRPDTVRPETPPEQPQILLPPFQPAPPPPPFHPGQWWFSNKIHTRLTPLQHSLLSTRPSPIPPSPHPNKCRKLRPWLILSLLPNNKALVICSTTRENRGSTGLTSAQARSFLPIAPTPEFCGREQVRVVLDERRVFVGRSLVFLEVVKVVCVGVLGEFIGWVGIEGEEGREGLERVLEGRREWGLGVERNGGDVDGRYSDRGGGERRRDREKGRGRGSWRDRGGMGSANGWSGACTDGVAYQRSSLLQAVPAESRPPSEGGGVLVRAIGVGKQVQGLVLTLTTEIFDCKSCDRSPDVHVPPPPYVVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHF7</accession>
    <name>A0A2T6ZHF7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_398461</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000269">
        <property type="protein sequence ID" value="PUU74844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHF7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHF7"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="223"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU74844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="322" mass="34639" checksum="5BF098B3BB953050" modified="2018-07-18" version="1">MASSKAIPPPSDFMRGLRQYISQPVTASFIAGGIAGAVSRTVVSPLERLKIIFQVQGPGNSSYQGVGPALAKMWREEGWRGYMRGNGTNCIRIVPYSAVQFSSYTVYKKLLLPEGGTDLGTLRRLCAGAMAGVTSVVATYPLDITRTRLSVQSASFASKGAPHTRLPGMWGTMKTMYRTEGGAISLYRGLGPTLAGVAPYVGINFATYEAMRKFMTPEGKANPTALGKLCAGAVSGAVAQSVTYPFDVLRRRFQVNTMSGLGYQYKNIWDAISIIIRAEGIRGMYKGLLPNLLKVAPSIGSSFLSFEIARDLLVALDPKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHI3</accession>
    <name>A0A2T6ZHI3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_916875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHI3"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="512" mass="58560" checksum="0C4410030259FE21" modified="2018-07-18" version="1" fragment="single">DIGSGSGATVKTCYYELLVVPRDATQDDIKKAYKKKALELHPDRNYDNVEEATRLFTGIQAAYEVLSDPQEREWYDSHREQILHGEHDSGASGGPSHPASVTTSEDVLEWFSMFAAKISYDDDSSRNNFYTIIGAAFKKLADEEITAAEHVGEDAPYYPDFGNSKSTHEDWVKQFYAVWGGFRTLKSFSWCDVYRYSDAPDRRIKRIMEKENKKFRDAGIREFNDSVRSFVFFVRKRDPRFIKNTQSEAQRQAALLAASREQAARQRKENLAKLKEFKAADWTQASHKIDDNSDDLGEDEETEEEEIIEKYECIVCKKTFWSEGQMGEHEKSKKHVKNVQALKRQMMKEHKEFDLDRDVRGIEKQQEDEEAPIETSEHEELEELEELEVTKSDTPHDTLNKNLQKLDLAPSKYQETKPSNPESNPKATPETEEEDETDRSPLPNSLNPSPPPSSSSPIPPKMGKAKQKRAKKAAKQAAAPGEITCVCCGEKFLSKTKMFNHLQEFPEHAKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIQ9</accession>
    <name>A0A2T6ZIQ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIQ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIQ9"/>
    <dbReference type="OrthoDB" id="5429050at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="15346" checksum="7488724FB7B8C407" modified="2018-07-18" version="1">MPGVPPNALGLLKKFGRSILGRKKKEKKTDTATQPEGTTAPPLAVAPVAAAGAAATVPIAAAPPPTEPTATTEVRGLIRTLPKVNAPTGATAGVEQHPPVPNAGPPAATELEAVTKEDAEASKTETAPVAGESSNVETVAPGYAAAAPAPAVEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ06</accession>
    <name>A0A2T6ZJ06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1090411</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ06"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ06"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="43643" checksum="732E29E0DD8C269E" modified="2018-07-18" version="1">MALNSFFHNKIESLELEIIERNSKLRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMGSKRVLVKVHPEGKYVVDVADSVDISKLTPGKRVTLLSDTYRLEKMLPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCRFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPTVEARADILRIHSRSMNLTRGIDLKKIADKMNGCSGAELKGVCTEAGMYALRERRIHVTQEDFDLATAKVLNKHDDKEMSLSKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJC2</accession>
    <name>A0A2T6ZJC2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000223">
        <property type="protein sequence ID" value="PUU75590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJC2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJC2"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="191" mass="21918" checksum="B517576C9EC68FBF" modified="2018-07-18" version="1">MAPYSDELKRLLLRHGIKLKGIFFGFPFAPGVAPRLLPDRYTELKSLFTAGRERVLAESWEKLLLDHEKQAAVMKKFGSNLIPQVRFQDLASISKEEIEDTRERGVVVIKNVLPEKERLAVKESLKEHIKRNSWTKDFPSLRLRPLLKAKKQPSLPTDSPAVYELYYTGLGAVYRESYLSLVISQCFLNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK58</accession>
    <name>A0A2T6ZK58_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial ATP synthase g subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1089400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK58"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK58"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU75877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="200" mass="21590" checksum="5CBF1DB25E007C14" modified="2018-07-18" version="1">MQTSLLRSPTVRQLTFRRFASTTTESASQAASQTASKAQDAAKQTAAKAQEAAKVAASKLMSAASGLGNSLGKIGGRTGQLIKGVESLLPQTIYYTKVAGELSKLVFHGQKMSPPNVETFQKTFSPILNMLKHPRALIDSAWASPTLQPTYILTQLRQLTSKEYAQFSVLGAEVIGFYTIGKMIGRRKIVGYRGGNSDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKF9</accession>
    <name>A0A2T6ZKF9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_943034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKF9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKF9"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="125" mass="13646" checksum="49C829AC6FB00974" modified="2018-07-18" version="1" fragment="single">LHLAAMEGDVQMLRMMLGECGIKVDIEDVYGRTAVYTAITSRKLQSVRVLLDAGEDINRRTYVHSGRTVLSFAVSRGEAEVVKLLLERGADVKRLDRGGRSALGIAVSNGYVEIVRMLLKAGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKH2</accession>
    <name>A0A2T6ZKH2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1066963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU75990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKH2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKH2"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="604" mass="60802" checksum="06FCBD2A3F328283" modified="2018-07-18" version="1">MENSGKSDSHHGVNAGGANKNTGTDDDEDLDRSGVGRGGGSFGLGAPQTIGRIRIEPVRRKTTHRRHQQLHARQNGVVSGITDPVGDIVSSVLPSTVKTGDYIATTLPTLTSPISSPIPELSSLSIPSSPSGTVVPSTSPSDSTNHPNVPVGSTQQTVLSSTPPPSPAETSPGMVIPPITISDIISTSLSRAESPSPSSASLSSPTIVLPPSATVTSYWPSLIVKNGTTTSDTRPASSTTIDGSVIVFTLAPSSTDINNTSSTTTSSSSSYSSESLWPTTTYVGGEGGGWGGGGAASTNTAPSVSPTSTESSGGGTPVSRKLLGGVLGGVAGMALILLALLYFMRRHKRELAIQARDDAGYGGPVQPAGDQPMAVVPEERGFYKVSGRKLPPVIGGPRPEEFSSTRSAPGSSHYHDDEISWIGPGAPIPSSPGAGPSKYSGVSESAPSSPATSSAPGSTTTPVGPAPILPPIGAAISTGPSRISEERESDPELASPGESMPPPSLPPIAKTPSAPGSQTDLGLTSPARPPFSRGMSSGSVGSAGSGKEGRAIGEVPASAGPAIPPAFARQMSAERVGSAGKDGVGRSLPSHDGSRASRFTEDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL02</accession>
    <name>A0A2T6ZL02_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1088829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL02"/>
    <dbReference type="OrthoDB" id="5375761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015580784" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23389" checksum="4D49F87358D1DDD8" modified="2018-07-18" version="1">MIPRRSIMALCLLTALTTVVAQDPTTTSDSVGAPTNTPVPSVITVTSPVLGPTPSSVPDPSTESSEYYPTTPGQSYDNNNDPNSIIDETKQEENNAGASGKSDTFVNIPLGAQIGIISAVVVVGVAGMVACFLWYLRRRRQYELSGRRSTIPRIGVNAKGEFTMGTQGDIPHRAPRLRAPSPVDSFDDSALEKGNVKSEFENESTKAPTGWKKMFSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL71</accession>
    <name>A0A2T6ZL71_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1130056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000196">
        <property type="protein sequence ID" value="PUU76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL71"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17289" checksum="F9BD035739C41859" modified="2018-07-18" version="1">MKPIYDGVLRHLIWPPLKRRPHISILHGTIESSEGGVPGALSMRSRSPFTMAFHAILSVYRQKDVPVRAFPMALQSLLKWGLFCWDFLVLGDYILLTSKPDSQSVRHAIMELFHDGVLRYLICPPPKGRPHMSILHGTTESSAGGVIMPGFFSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLB5</accession>
    <name>A0A2T6ZLB5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_260820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLB5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="8486" checksum="E3A390A3B0D850FB" modified="2018-07-18" version="1">MHSSAIVYMKLNRVVYRCSMQDFLPYFSAMVHLIFPRAQRGFFFPFPIPRMEYRVTGIITNRCSSTKNYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLH5</accession>
    <name>A0A2T6ZLH5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_991067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLH5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLH5"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="70"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="268"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="530"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="101703" checksum="714333E6D24C3491" modified="2018-07-18" version="1">MHHRRRAPPIVLSPAPSPGADDSNGHVNTIDIVHHFESQANPAKPARPSPLTTSNGMPLVLLERLRSFPLFLSAPEEFLSAVATHLRPQPYSPRDYILTEGDEAKAMYWLVRGAVAVTSRDGESTYAELRPGAFFGEIGILMDIPRTATIIAQSRCLLVVLTKEALQRELPKFPEVERAIREEAEERLTLLNKKKKERESSPRIGGIKRGVDSDGDVEIGDDVYLKSDAPRTFGGPGLALKPGSQWVTNSALGSGQVNIRQLLKELPLFANLPQENLHFLGLSAAPRTYAPFQTIIQQNSMGREIYFIVGGEVEVVDELIMDPKQNKVKARLRKGQHFGEVVALSLAPRRTATVRAITPVECLVIEGDVLEELWKKCPPEVQQQLEMTARDRMDGDGENILMRDAPATPTQSIDRLDISDLPKTSSMNLTVPESRFTGPNDSNVVEPFDPDPYLPTDFESLRSKSRRGSLAPPPPQSSAASSSSSPTEENPSPLSRSTTPSPAKTKHVTTPPEHHATVKRARILSRKPSRFNIGQFKDDILIQIFKHMELHELMRVRQVSTHWSRLLTNSPYLLNTLDLKPYNRVINDNVLIHAIAPFVGHRPNLIDISNCFHIGDEGFTVLAQTCGANVKVWKMKSVWDITGQAILEMSNRAKGLEEIDLSNCRKVSDTLLARVVGWVVPEFHPIYNPGQQAPPQPLPMYPAPGTVIGCPNLSRLTLSYCKHVTDRTMSHLAAHAARRLEHVDLTRCTTITDQGFQSWSMTRFERLRSLCLADCTYLTDSAVVFLTNAAKGLQSLDLSFCCALSDTATEVLSLGCPHLSVLKLSFCGSAVSDSSLRAIGLHLLELRELSVRGCVRVTGVGVEAVVEGCHNLEVFDVSQCKNLARWIESGGVEKCTQTWKRNIRFETVAVDVVAGDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLL0</accession>
    <name>A0A2T6ZLL0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP cyclohydrolase 1 type 2/Nif3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1115947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLL0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLL0"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="31849" checksum="EFC06E3CD79628B0" modified="2018-07-18" version="1">MSSNAVIRSRTLRTVVSAVQKLYPQALADKTWDNTGLLLEAPDRTDRPSPKTHKVLLTIDLTKAVADEAISLKPSVIVAYHPIIFRPLKSLTLANTQQESLLKLAQEGVSVYSPHTAVDAAIGGVNDWLADGISGGRGEESGRVVIEEVKDVPGCEGSGMGRIVTLKEPREFQELVDRVKGFLGLKYVMIGKAPNNKKIRTIAICAGSGGSMLRNIDVDLLFTGELSHHEALAAKERGVGFITCFHTNTERGFLRDVMKGKLTEVLKNEAEREGEFEVVVSEWDRDPFEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMR5</accession>
    <name>A0A2T6ZMR5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1087631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMR5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMR5"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="420" mass="46712" checksum="B1A6D99866D3E4C0" modified="2018-07-18" version="1">MSGTKPSNTPLAALRQGLTRAASYNAGLHIRDLHGAPPTPNEDYTTPVEIVTPEGKRLLIKNTGIVHTISHKNCVPTESALRLVATLFYNPSQSLVTADGEEISVEKHDVNFGPYVSDMAMFEFTQTVDELLVPWKKWGTNHRCLDSAERPKVMEISLSMPEMLQLNELRRHTSLWHFERKWNVELVLQENNIFRRYKRLAVFDMDSTLIEQEVIDEIAKFLGVEDQVSSITARAMNGEIDFTESLRQRVTLLKGVPSTVFQELKSVITFAPGVRELCRVLKTLGYKLAVLSGGFVPLAEYVKEQLSFDYAHANNLVVSEDGKFLTGELCGPIVHAERKALLLEEIAKENGIALEQTMAIGDGANDLLMMKKAGIGIAFNAKPSVQVAAPTRLNSETMLDVLYILGFTKEEIQALLAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN60</accession>
    <name>A0A2T6ZN60_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CwfJ C-terminus 1-domain-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1115652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN60"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN60"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="305"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="454"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="527" mass="57312" checksum="9DC025BE95B731F1" modified="2018-07-18" version="1">MAAKVLVIGATNGRFVEAFAKVTALHAKNNFSLSLLLGDLFSDPSQTTSEETENIKRLLHGEIRVPLPVYFGLGQYSLPVPVREKINSSGEVCENLFFLGKKTVLNTSDGIRIVALGGRLDAGLATGEAGGTEGDTLPFYSEQDAKGLKGANLADLLLTYEWPEGVGSRSALASPGVKGTSVIAELAAALRPRYHFAAGGEVFWEREPYQNKAKPGEGGSDAKITRFLGVADWGNEKKAKALYAFSINPKDTNITIPASATACPYKEDGGKKRPRQDSNSGANFFWGDHTSGGHERGDRGGKRGRAESCFFCLSYPQLEKHLIVSIGNEAYVTTAKGPLTNSTVNPSTLPFSSHVLIIPLIHTPTLIAIDDEDSRKSTIEEMTNYRLAIEQMLKSRGCGAVTFEISRANGVHSHWQLIPVPNDKLAAVEEAFKGEAKVDQIGEFEKRGVDAGNEGDYFRVWISGIDGSLVVSLKEGEYFDLQFGRKVLAKVMGLKSVHWKDCAQTFEQEVKDANDFKEAFKSFDFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPD1</accession>
    <name>A0A2T6ZPD1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1086443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPD1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPD1"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="35114" checksum="452929709FDA2412" modified="2018-07-18" version="1">MGKSSKDKRDSYYRLAKEQGWRARSAFKLLQLNSQFNLFADVTRVVDLCAAPGSWSQVLSRTLPPTSTIVSLDLQPMTPLPGVTTLQADITHPSTLPLLLQHLGNKPADLVVSDGAPDVTGLHDLDEYIQSQLLLAALNLATCVLKPGGGFVAKIFRGRDVAVVFAQLRCLFNRVTCAKPRSSRGSSIEAFVVCEGYSPPAGFKASLEAPLGLGMKFPEKPNRSDKEEEHLVDGVREIELRELEGGEDGDHDSQEARYIVPFIACGDLSEFDSDATYALPEVDEFGQKWKSKDPVQPPTAPPYKTALEMRRQLGGGGGGGPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPN7</accession>
    <name>A0A2T6ZPN7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPN7"/>
    <dbReference type="OrthoDB" id="10609239at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="309" mass="34188" checksum="5D682F5E0441674C" modified="2018-07-18" version="1">MASLSLGDVWKELGNLGMADLKDFPADKRPRWIRAYLNRLNTSSPPPTSPPLTSSEMVSICVSNPSSPTLTNISSASSSSSSPRMTSLLSHANNTPHITPEDREFLHAMSGKHFSIIRTLRRISSMRIYMREDIEDIDAFVTEIKRALQEMRAWLLRFCQEVQPLIADDDEYGGEEGDDASHRRRRHQAMVGALAPVVETICLFYDFWGHKERSAGLRDERDEGRLRFACTEIVYPSQPKEVGEAMEAYLAEYPGHRISCGGGEQGSSGMGGGSAGVFPFPLVGYSDGDSVEREEEAGISGLFAEEYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPX9</accession>
    <name>A0A2T6ZPX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1101815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPX9"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="106"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="849" mass="94341" checksum="24CEE61E5BF77F27" modified="2018-07-18" version="1">MFQGRRGSKRRGSNASIEEYQTVPIDDKCDAGGSSSWRDDGESKAFFEMQTRGDSDDLEAPSPPSSSLRPSQRPSATRSRLPASSARFSILKGPVVAAILDGSISWRTGVKICASIATATFLLTLGITIYFIIVYPPEGTGLGKLYLGDCEDMKKISFWTHVAINFLSSILLAGSHYTQQVLSAPTREEIDAAHETKDWLDIGIPSIRNLKTVGHLHRMERIRVWVWWTLGFTSIPMHLLFNSAIFSTLSLNNYYVAIVTPDFFNGTSYNQTGHVISGLRAGTMGSVIVEPFVEGFNYTFWNPNKPGARYVGHYEYGRESIYTGNVQIEGSFYNTTNSSASVAAKIMAEMTNAWMPDYNFEQMREVAQIMSEGRGNWSNMSTRDCRAKYSQPLLGDMQNLVLVSSTKPKDYSSLMSMIMYNSLEHKHYWMCQNESSLIDINNWNKTDYAFPKNCETGVDDGKRGIPDGDWVVRGHTITECRGQKTQTKCKLQFSVGILAVVIVANLLKAISMAMAAFRMKTVPLVFMGDAIESFLKEPDITTLRRCLADKTMAESSWELRPTPKPYAPEQWRWWHAPSKRRWLTTVGTWVGIISLSAVFIGTGYAKDARNGMETDIKSLVKRGFGAQTTSSVLSSRDGGLIIPIFLANSPQVVLSFLYLTYNGIFTSMFMAKEWMEFAIKRKPLRVSQPTGQQRSTYWLQLPYRYSLPLVALKSITHLFASQGIFLAKFEVFNPLGETFKVVSTVGYSVAGLTLLMVSGFIHLIILFIVGSKKYPLGMPLAGSCSAAIAAACHPPEEDVDAPYEPLMWGTVPTKPNSTVESKVGHCSLSSLPVGQPIIGHLYAGKDKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ65</accession>
    <name>A0A2T6ZQ65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1145247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ65"/>
    <dbReference type="OrthoDB" id="5396890at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="184" mass="21005" checksum="9E03B9C95A5BC925" modified="2018-07-18" version="1">MPTTQSQYAGYKHRVLQATMTRAYNAAASCRQRINETTTSLLRKLNAGRIRHQLAKENLERGRSAMIDRILNTRDCAEDLLKLNTEQYSEEARMLQDEADSLVQGPLRFTSDGLDEETLGFQKWEEDALKFLDSLSEEAEGLRGYLVELARQAQLMGVEIAWWGNPEDPEARVENLEEGELLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQD4</accession>
    <name>A0A2T6ZQD4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQD4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="7465" checksum="1C330A396FB7BCB9" modified="2018-07-18" version="1">MNAKNSLNHSLNARMFHKVLHVSSLGRIQSSEHTPISPHSTRKHLIEKFSDDKSTKPHPVIASASPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQJ6</accession>
    <name>A0A2T6ZQJ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_985801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQJ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQJ6"/>
    <dbReference type="OrthoDB" id="4305729at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="392" mass="42996" checksum="BC73738B53ED5434" modified="2018-07-18" version="1">MPLLSLPNELILQVSRIQSIQELNSFSKANRRLHLLLTPVLIDRVYQLCTRDGRYATNTLYLAAECKAVSVVRALLDKGILLCVPGSGWLLNNIISTLGHPDAVKTAVETLLECGVEADSPGYKGWTPLILTSFRGYVDTVRLLVSRRDVNVNAQDDDLRTSLAIAARRGYKDVVQILLSHPLIDVNLAEQSRCTPLHTTAGGMIRGGEEIVKLLLEDTRVDVNVVNKVGWTPLHIAAATGTAAAVRLLCDDPRVNVNAPNKSGWPPLQLAAERLAEGPLRVLLDCERVDVSLARPLHSVIRGRKEVLVRILVADERVDVNARDSETGDTPLHIAALLSFDVAVMLLLRRGDIDLSATNAEGKTVGMLAEGYSPRIRKVFGDHAMFKRKRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRF0</accession>
    <name>A0A2T6ZRF0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRF0"/>
    <dbReference type="OrthoDB" id="10590525at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015669092" evidence="1">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="97" mass="9785" checksum="E62EF00A6878B41B" modified="2018-07-18" version="1">MAVSSLLTRALVFFLLAMLAVSANVHSANGTGLPVAPTTNNTAVPTFTTPAVPTGTSDQPSSANTLSSTVALFGALIAVGYPSTPTEMLKLVRGHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRM5</accession>
    <name>A0A2T6ZRM5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRM5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="10512" checksum="946CA2652EF0AC2E" modified="2018-07-18" version="1">MLHIHPNLPITGMIHYLKFFFSIGSIIEGSSTHRHADYAVCTVCIMLIHYYDRYPSLDVFSLLVPFFIMYLIFDLYLGISVWLMWSVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRV9</accession>
    <name>A0A2T6ZRV9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRV9"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39219:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015774191" evidence="1">
        <location>
            <begin position="24"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="23706" checksum="D534589C2D503F40" modified="2018-07-18" version="1">MRTLIHLTFSLTLLLSHLAPSTAFRSRLTTSEVRDAALSLTEELYQWPISAESPTPLCELWYHERLADALCSSAGRKNCAMTGECSDDEIVRVGIMDEEGVFRGVATTVGERVDWEEQKALKNPDKALINIRRDRSNPAKVWRVEFQTVDTPEELDATTNPTPGPQPFLNKPIVLNAEGKLPEPDVEKTFLQKYWWILLAAALLILSGGGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSB0</accession>
    <name>A0A2T6ZSB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1126885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSB0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSB0"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="132"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="573" mass="62708" checksum="B56EF7FAB09DDB02" modified="2018-07-18" version="1">MLGRSCVALGIEKAERQASSQMHHGDNYQPHSSDLSSSSGSGSTISAGQATQGEAECHRIEVERERTHLSTHSNPLECAFVGLASNGELPPFGGGREYPPPLPHRDRYLVDFSGKNDPIHGQNWPLKKKLITASVLGYTTLVSAWGSSVFSPAAGQVAVFFGISLEVAILGLSFYVLGFASGPLIWGPYSELKGRRPPLLLAIFGFSVFQIAVAVAKDIQTVLICRFWGGFFASSPLAVVGAVFADIFSQEARGTAIAVFAMAVFSGPLLAPIAGGFIAESYLGWRWTEYITAIMGFFALFLCLFFLEETYPPVILVAKAAELRRLTKNWGIHARQEEIEINFKELVEQNFGRPLKLLFTEPIIFLLSLYTAFVYGILYIFLTAYPIVFGEIRGYGLGVAALPYIGLVVGMLFGGLLVIAFQPWTNRRMKANNNIPIPEDRLVPAIIGSILFPIGIFWFSWTGNYPDIHWAAPTLAGIPLGIGLITIFLQSINYLIDAYLMFAASALAANTFLRSAFATGFPLFGRQMFHNLGVNWGGSLLGFIAVVMIPIPIGFFFYGARIRKRSKWAPTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSL5</accession>
    <name>A0A2T6ZSL5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSL5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="66" mass="7407" checksum="04394CC690D989EE" modified="2018-07-18" version="1">MGASIVPGKSTLSDAHPHNSFLLNLPNKLFGTVLYRHCLHWTRDQTGRATHWRGGTNPNPKSRATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSV9</accession>
    <name>A0A2T6ZSV9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000116">
        <property type="protein sequence ID" value="PUU78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSV9"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26013" checksum="21885BC4F52F05E5" modified="2018-07-18" version="1">MVWDDQSLSGEEGSYNWISDRASSRRLIQKCPLTKIPELLYKVFEDFYDQAARFKRRNGRCAVFIIDNVNRLAAENPKLLAGLQDHAKDATDSKKFIVVFVTSEGLATQQMLDIETSVLQAANSAFKKARFLEPGEPRTKAFKIISGILKNGKIHSKDFFYIAGTYEQETRLLSCNIFATVPESERITFQSKPIEIVARKLLAEMESWEWSGVPWLWKRAEQGNLHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTH4</accession>
    <name>A0A2T6ZTH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTH4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="85" mass="10035" checksum="09C308C4D31D0C51" modified="2018-07-18" version="1">MSIFRSMVVFSPTYGWLYSISLSARPGQSAPLRSVHTLSVFFISSIICEGCFYLRIGADGWVCCLYFYYYYYYYHIIIIFLLRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTP8</accession>
    <name>A0A2T6ZTP8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_888931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTP8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTP8"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10408" checksum="AB378CFECFDA7740" modified="2018-07-18" version="1" fragment="single">QGNLSHEVISGAAAFEGFKLFENHQRREGKQVSHGTAKEILVGLATAEAEKLIEKKGLGTHEGERAKHATRQNAEWMYEQYNNGDQYNPSSQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTS2</accession>
    <name>A0A2T6ZTS2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Component of IIS longevity pathway SMK-1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1126017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTS2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTS2"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="13"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="159"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="887" mass="98968" checksum="95302626BA64E84E" modified="2018-07-18" version="1">MALSVPNPPTTPRRVKVYELRNNDWFDRGTGYCTGQLVNHGSLVSNKVADIRGAQDEPHIQVKSEEEQDRMLLETKIIKDDGYQKQQETLIVWTEPHGTDMALSFQEPEGCAAIWEFVSHVQSHLLSISGADEILSDDANETPISSVMLPSPELGNLTEIEAMIRSASSTNQARDSLGKFVLSEDFIRKLIPLLEMAEDLESLENLHRLCNIMKMIILLNDTLIIEHIVTDEVIFGVVGILEYDPDFPSHKANHRQFLSDTSKFKEVVPIKDPEIKKKIHWTYRLQYLKDVVLARILDDPTFSVLNSLIFFNQVDILQHLQSNQAFLKELFSIFHSTESEPTQKKNGVLFIQQCCSIAKNLQGPVRTQLYSHFIQNGLFAVIDFALLHDDASVRIAGTDVLVAMIDHDPAMMRAFIFRQISDKQKPLTDTLIELLLGEQDLGVKAQIADAIRILLDPSTGLQVEGLGKASDITSRLHPRNHNADRETENFLKTFYDDSAKKLFLPLSELDNRKSLKGLSIAEVSLFSHLVDTLCFFVRQHAFRGKYFLLAENLPSRVAQLLQSPEKHLKLSALKFFRTCVGLQDEFYIRHMIKWKLFGPILGIVIDTMPRDNLLNSACLEFFEFIKRENIKQIIVHLGENYRDQMKEITYVDTFNMLILRCEQLQDTTMPSSYVQEDKSIRNHVNGARRWQGVKDMDAAEEEYFNTSDEEDNAPTPKDSPIKGANGSGSPVPKPLVDYADDDPMDTADESKPEEKGGTATPTKPALEGASSASPTTSPTTLSPTSQKSDSDVLSGAPTPERLSEKRRREEEDDDELGKLRNKRRSPTCGSGSVNVLTKKRGSGPGGSPPTKKIAINLAVKTSTGSSDGGGGGGDVTGDGGGEADDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU21</accession>
    <name>A0A2T6ZU21_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_22656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU21"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU21"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="3">
        <location>
            <begin position="16"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="20681" checksum="4D1214BD649D422C" modified="2018-07-18" version="1">MSPTPFKLPPAHTVPTLSTRKHIEILSALFEPCPALNTLALEYLAAGPFESYDDLVGIVYGLLADLNGSKTPKNTEWLLKILAAHPRLGAKKIESELSAEEQASLAAANAEEEEALKRLNDEYEKKFPGMRYIAFVNGRSRQIIIKDMEKRISRWDSEAEKEEAIQAMCDIARDRANKLTPQKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU87</accession>
    <name>A0A2T6ZU87_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_980654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU87"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU87"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="52975" checksum="FEDEEE73A1BA648C" modified="2018-07-18" version="1">MNSTSSSPSLPISVASAASKSHQPLPAKHPSRTNPQKSNGSATATAATTVTTTTTNGGGSGGSVGSEWGVQWSALQGLANSVLGSSAAAAGSDSPPTQPHEPAAAAVRRRRRPTDGTTPTGSVGGGGRRSHSSGSWLGEIPFTEADASKSAGSSGSGEARPHPTRRLNLDEPSSRNSTRSRKMPHKRSTSPDPTDGPAPLSVPEAERDALAYVHHVKPTDTLEGVVIMYNIHTSALRRANGMWPNDNVQRRKILLLPVEDCGVKGKPVGLLNLELTCDQQANLPSPPKEPTSEEKAAAEERGYRHESYVIIDGIGQVEIARLARKKLSHFPPRRRKESVSTNATAGFGTPPPDDESSVFRGMTPGVGTLGGSGSGAGVELHAEESITKALMEFAHGTSAGLENVGGVIEGFVRKWTAKAQDFATHDLIELTQRLGFEIEEGESGGSSGGRNGGGNANSGDGSGERATRDRRRGSSTARGDRRVVRERLPRPRGERGDGAKNGYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUB1</accession>
    <name>A0A2T6ZUB1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1082649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUB1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUB1"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="662" mass="70792" checksum="00AA709DCE87DE90" modified="2018-07-18" version="1">MSYPVAEGCDPSEADMLLIKVMSPVFGFPRDLTFRMLATSTIKDVKDKITGSLDSRPPCDQQRLIYRGKMMQDENRLETVLGLNSGLVGSDPREAFTFHLMLRPPPNPASTPASATTSVAQNALPNASTFQTRPGPATPIFLEQASEENTAHAGLGELSRPGLQRLEGLQRQLRQRQEYLNSRLGPDQASSSGVSAPGASSNGPAPGLGTNATSSLTRTLEADTSNGSPNSDPVLGSSWGPPRSPSEAVAPNQGRPGQRHAHERLPERFSRREDTTTAAFTGLSPLEPLPVFHLPANNPHPITRASPVYLLQDASGRPRALLLGPPRSANPTLAEIINGLRGPLEPPGVGIPDLRGLGLPPPPDPANLGAMGGIAGNNLLAAGLGLGDHFGGAHAHHRVAFHGAVLERPRRAGLLNLADLIRGVRAHASHFWLAIRLAVFVVLFTGSGGWRRMLYLGSIAVAIFSKQHIPISILHNPLIPQTVWQTGVLEPFLRPVIDAINPPPPPPAQPPTPTPTQQAPNQPQPQATAGNPNNDNPPRHAVDVNTNQPDPARIAQILVDRQQDRFRDIFRSIERCIMIFLASLIPGLHERHVNAVEQRQRDEAQQQQLLQQQRQQAAGSGGDMEVNNGGEGGGAGAGQVPPPAPQPEPQMDEVDVDPLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUH7</accession>
    <name>A0A2T6ZUH7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_850892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUH7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="17509" checksum="773C01F4596AE8EA" modified="2018-07-18" version="1">MTEIVFPIKGLNMQSLQPLPEVPGKKNCGIYLSSPSWAPFRKQTFLSHIILFTCGATPYGSLQLRCLFNSVVKPRHKDKPSATQNCKKKQKMETRVILLPLTPQFQVIIWKPQPSGTVWLCHYQTTPFWTSGNIFLVTQHTGSSMAPLYPYLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUU3</accession>
    <name>A0A2T6ZUU3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000096">
        <property type="protein sequence ID" value="PUU79262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUU3"/>
    <dbReference type="OrthoDB" id="10464656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="238" mass="26724" checksum="96214D47A65DBD68" modified="2018-07-18" version="1">MRIAQLLDRVAYLRSWIAYLPEVPKVYWKKWVSESWVSRQGTKGGDDKEDFETTTHNPEPAMAAPIRLIVNRSIHCTGSTLTDYVNPYSSSPPSRDLLLPESYPLPTAIVPDTPTTQQLYDEDPFKTPVPPRAGDPGFLDAYPSPEGGSKWQRSKKSLAEKRMEAWKFTRKTESKAPEVSVKEFKPSPGSEPGFLDAYPCPPTPTNWLEDDVEVNVKQDGNEESNNSKEDNSITTHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVK6</accession>
    <name>A0A2T6ZVK6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1125036</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZVK6"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="35"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="136"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="734"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1065"/>
            <end position="1512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU79530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1528" mass="170951" checksum="A055DF1B57CF6A97" modified="2018-07-18" version="1">MAPPLIYMLPLADTGAPDIAGDHISLPPPREPYTLRIAIEGASSITRNGSLWTNVPAKGEKFGRNKFREFKLTPSFSRTLHIDIPIALPGTFSYYITYNPLPSLKELSSPTKPSETARTDTHWFTVAARLSVNGEPLALDSLSCFSVVSKWLGPVKKWDGYMRYIAEKGYNMVHFTPMMHRGESNSPYSIYDQLAFDPEAFPSGTKDVMLVVDRMEKQHGLLSLTDVVWNHTAHNSLWLQSHPEAGYNLVTAPWLEAAYELDTALLDFGGHLEALGFPAELETKEDLLKLMDGVKTHVIGALRLWEFYVVNVEATTDAVIDAYISGKSNLKRVDIAEYKSELSLYDKAQFLIKNGLKGADTLGSRHSRTIDPEIGAAFLTLECGKPSPKNAKQVEGAKQALIKILDEINLPFYKEYDLDCSEILEQIYNRITYLRLDSNGPKMGKITKESPIIETYFTRLPKNELTSKHDPKSLALANNGWIWNNVADFAGPKSRSYLRREVIVWGDCVKLRFGDKPEDNPFLWQFMVDYTKLMARCFHGFRIDNCHSTPIHVGQYLLDIAREVREDLYVVAELFTGSEYEDRRFVEHLGLGSLVREAMVAWGPGELSRLVHRHGGKPIGSFRQELVVRGGAVSDAPSSKSEANGASDGREVIRAVTASRIHALFMDCTHDNETPTQKRTPQDTLPNGALVAMCDCGIGSVMGYDEIYPKLLNLVTEPRIYYPPPEKIDGTTPGIGRVKGLLNRIHTEMGKDGFTEMHVHHEGEYVTVHRVHPKSHKGYFLIAHTAFGPGDHRGDFNPITVTGTKVKVIGSWTLAADGSDEEKESVLNQPDYLTGLPAKLVEVENPKIEENGNQTTITVPEKFPPGSIALLETWIPGTDGESLAQFVTSGAEEAFAKTSLVDLNFVLYRCESEEKDSSDNQDGCYNIPGYGALVYAGLQGWWSVLKDVIRNNDLAHPICQHLRDGQWALDYIVGRLEKLEARGNKGLAGPARWLKERFDRVRSVPGFLLPRYFALVVQTAYTAAVERATSLFTEDIQEGTAFLKGLSLVSLQMTGLMNSTSLWPDKKVACMAAGLPHFSYDYMRCWGRDVFISIRGLYLATGRYDEAKEHILAFGSVLKHGMIPNLLDGGRKPRYNARDSIWFYLQAVQDYTKMVPNGIELLQEKVKRRFLPSDDTWFNHDDPRAYSRESTIAEIIHEALGRHALGFEFQEANAGPGLDSQMKWEGFTVCVKPDWTTGIIKGGSQFNCGTWMDKMGESEKAGNKGVPGTPRDGAAIEITGLLYSALKWVAELKKKGLYKWDGVKTSEGKVITFAAWAELLRKNFERLYYVPKDPAEDSKYSIKPELVGRRGIYKDLCGGGKEHEDYQLRPNFTIAMTVAPDLFVPEHAIGCLEIADEVLRGPTGMATLDPTDKDYRPYYHNSEDSDDFATSKGRNYHQGPEWLWPTGFYLRALLTFNPPNIETLQQINLRMDGCRKAINESPWAGLTELTNKGGEICYDSSPTQAWSASCLIDLYYDAAKVKLQPRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVT9</accession>
    <name>A0A2T6ZVT9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_979159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVT9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVT9"/>
    <dbReference type="OrthoDB" id="10402082at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="20192" checksum="3761719F9696C2A4" modified="2018-07-18" version="1" fragment="single">MFALPDNLPELPRSDPSSPIAMYTLPDNLPELPQSDPASPIAMYPLPDNLPELPRSDPASPIAMYPVPDNLPQLPRSDPASPIAMYSLPDNLPKLPRSDPASPIAMYPLPDNLPELPRSDPASPIAMYALPDNLPELPRSDPASPIAMYSLPDNLPELPRSDPASPIAMYSLPDNLPELPRSDPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVW3</accession>
    <name>A0A2T6ZVW3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1124919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000086">
        <property type="protein sequence ID" value="PUU79627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVW3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVW3"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="570" mass="63467" checksum="58C7D6CDEB0211A5" modified="2018-07-18" version="1">MDRAQSDLVVWYKLETEFFQDHVRHTRYLEKAKNRNEKVEEDWSNCGELGRGGFGVVHKQIRKATGHYRAVKTIDKRLSIELDYSRELLVMAILTKHPPLFVEFLGWFEEPETLYIAMEYFKEGDLSKHTGTPLPQEIVQDISKQIFEGLKVMHQQGIAHRDLKPANIFVVSMSPVWVKLGDFGVSKRIRAHGTTTFHTQVSTPVYGAPEVLGLDSNSETSDYTNSVDIWSLGCVIYELLAGTKLFVSEFHVSCYLFGKWLFPEGMLRGLSPPTDEIGISLLKSMLVIQPEDRPTAAGALRHPWLAGLESHEEYGRDDERETVPICNLRERGDLITEGDIDCFLGDCAQRANSGSAGGDSSAIPEATVDASVMTPTDAASAEISTVQTRPQNFEQPLRYHFAPHFKRLNAVGKKQIYDIPPTCPENPQRAISQRLVPTKEIVSNQLHGQMSPRNSLHRTCGRSRPITAAGGMAETKMAQPSINYKSLTAGKTRILAAILIGFLMLAGILTKIPKLALILTGILMLAGMLAGIPTLSRTFARISMPATTLTSEEIEISDRTEWQSRTELNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWD0</accession>
    <name>A0A2T6ZWD0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1192401</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWD0"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="143"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="639"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="924"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="924"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="955"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1011"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1129"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1155"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1216" mass="136138" checksum="7E9B971386C1A11B" modified="2018-07-18" version="1">MSAIGIPVFSPIPPGFDVKQLAEEPGSHFHLATRVDARTLTPDTAEQFDEIYRSQVLQIGEPLVIENWHLRSRWPGHIFKDEWLDNNLGRQRVQIRDLVKGTDDEWSLGWYLSKCETLASKFTPENYKSFKRQRLYLKDMDCPPAWMKHLGDILPKGTFYLDENADLMAALPEELRAVNMMCYVGHEGTFTPCHKEMCSSIGQNIMVSASENGKSIWFLVKPDDRAKLAVWFRSVLGQDLELENYFASIEDWKKAPVDVWIVEQRVGDFLIIPPASPHQVWNQGDLTIKAAWNRCTPESLKVCLSGELSMSKFACREEAYKVKTMVYMAMLKIANELDRTSSNENEGIIRDFLTLYPLFEAIMLDEAFSPELPVPAVEDTLAEYGITCSFCSGNIFNRFLSCPSCPLGDGDNADHYDICMDCYTLGRRCKCDAPPTWVQQYSWTTLRNDHQRFRQIFNGFVEGERFASIFKRAGVARSTRESLEHLTSIENVTRKSRAWVSQILSDMYTRYPGQKRGGLRAIKETPKDEMDRSNCHVCKNPHAPIIYVECSNAGCTKRYCYGYLWRAHSQNPYVILSSMNWRCPFCLKQCTCAACLKSGRNGRRARRENPIWLGYNTRAVADQRSEEWLTTFAQHNKKWATSTGDSDGASQKRKRSDGSDRESDADVDGSSGSSGGEAGDRESVGDEDEVVNDEEDDEWEGPGKHPGLLEFPSAVGVRGGDPSFISGKRSTNVNLLASQLALLARKCDPSTGETDGEGGKDINVIGGRWRDQNNSLALLDNHSLENNTIASPLSPGLDNSALRSNNLSQLEMDPQAFRIAAGLLTAEDNTPVPLTQQPSAVSPEALSLPLLLSGPARLEVERIVKSPTPEPIETKVGWVKKAKLARKRFANLQAGKNRRKSLIVKLKVLVKEWEEAPVQSDVLPKKIPSEEGERESEALPAQPLSPPQEHQGEGLLEDDVEESAEDIPSDGPSRRRKAAPKDGEYIARNRTGNPPTPLMALSSVRSRRRSQSLQHNIHNNSSNSSKHTPPLEQPSIPPPAPSPPPLTSLIPADWPFAIIITKKPDHHKYAKTTTTGRPRGRPRKVRPAGKAREDGDFKLAPWSKVMKVEGTTLTKESVRPRVASAAFAEDVEESSEDDGEGGYVERGPRPVSVDSGEEGDGEELERERMVVGKGRVRKQRKVGGQEEGEERGGRGGGDYDEEDEYNRRWSRRRLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWS2</accession>
    <name>A0A2T6ZWS2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_771640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWS2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWS2"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="118"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="432" mass="47665" checksum="128DFA1000EC641E" modified="2018-07-18" version="1">MAPSLSQAWKTALSFRERVAIVEHIASLLELSDSSIEYSSALSSARAVEAESYEGSFSQEEYTRTWEAKLQELKAKYAEKQLEARNLSAASESDNASNDSTSQDIPHATDRGITIGRFTGCRHHNSGVFSDVYKALLKPMTLMSPAQFVALKVTIPSRMAPPHDSHREARILQKSEHKCIVKLLEKFTLPTSQFVMVFPFYNHSLDTLLKSNAKITGDQMAGIFQDVLCALEHIHSLGIIHRDVKPSNILLIDADGPAVLADFGIAWSPNDPESEPAEHKITDVGTTCYRPPEILFGNTAYGASLDMWAFGCVVAECYTDGHESLFDAGDLGSELQLIGSIFRKLGTPTLETWPVGISIPLNSIYLLCLTLQEASNFSDFGKICFNNFPAQKWEDILPRAPRAVRELVSELVVFESGNRLSATEALATNLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX00</accession>
    <name>A0A2T6ZX00_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_770029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000075">
        <property type="protein sequence ID" value="PUU80017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX00"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="21541" checksum="E889926088F7812E" modified="2018-07-18" version="1">MRAQGESSGWWVGKPRSRAVASLEMRKRDVASFEDSGDSVRNGAVRPSWARTRTDDISSSRPVFLSTCPTSENVGRGRTALCHPPPSPTVPCRPPPSSVVFRCFLSSPAVPYLKFSRPWGLSSLLMTAVLGAQGRGRTTFCSPVSSGGLGSPPTGPYGGPGRLRTLSGGATLLYMRGPGAPGPPPSNPPHPLPNWQRVVPTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXP6</accession>
    <name>A0A2T6ZXP6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1063618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000070">
        <property type="protein sequence ID" value="PUU80224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXP6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="135" mass="15521" checksum="91DE2C4DC5A85824" modified="2018-07-18" version="1">MIQSALYLCLAIDRLLTINNSRKLCKARVLLTIAPQDWDILEFVENIFSFFVDATEFASGSINPRLSSQLPYYQFIQNTLNELIENKYPLEDNHNPNSATYQICSAADDTYQKLNQNWIKTDTNRGQIIAIILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY12</accession>
    <name>A0A2T6ZY12_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY12"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY12"/>
    <dbReference type="OrthoDB" id="5340391at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="28618" checksum="D189739F1DF4B04E" modified="2018-07-18" version="1">MTAKEVDTKLIFGLPWKAIREAKHVCGSDGSAIPVEYFGGNPIPSLENIERVDGFTVSEQGGKTAFRLSASASQGAFPAGDFCCGCLPGHGTSNEQPINFNNAIPLNSKTEFPIRDLSTNEGYACKYVSADDLGSVGCFPNLLNFRKVQKIDSHALIAKVSLEDVKEKLIKIIQERVKQTEAKPRPVGFQLCIVTISHNGIDVPSLYTFYSRGAKPFRKLLMKTIFQSSIGPSKLTGTSIPQVTAKPFRLTKERSTLRKCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYA5</accession>
    <name>A0A2T6ZYA5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYA5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYA5"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16817" checksum="DFBE88A2BDCD357D" modified="2018-07-18" version="1">MLRAPFKTRRKVKVLTGLHNNQIPDGEEAAEGITTIRSETGEPIDFSSLLPMVPDSDFATPIIVRNNPKELTVHFGEQLGKIIRQNYMSMTLESFDPAPSNNLGKIFKNFPERTTSHTYLSPAGLLSRTQFTPPAITLTEKAPIEDIKYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYW4</accession>
    <name>A0A2T6ZYW4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Velvet factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1100162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the velvet family. VelB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYW4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYW4"/>
    <dbReference type="OrthoDB" id="1746739at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="8">
        <location>
            <begin position="60"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="356" mass="38489" checksum="B04CCFE19C24DB11" modified="2018-07-18" version="1">MYLTQPNHPNQPIHDRHHGIPPPLPMTRVSSSSSSSQSAPPANNGLIQSLQQPPSQSCRGDGNRIYSLEVKQQPIRARMCGFGDKDRRPITPPPCVRLVVKDATTGKEVDINEVDTSFYVLTVDLWSADASREVNLVRHSATSPSISAATSSSYPPPPPTPPPHPHPQAHGHHIPPHQQLQHQGYPPPPPQQQLQHQQAPGPYPGYHPAPPHAPPPPHSSKITISTPAHQGIIRPPQQTPSGMFTRNLIGSLSASAFKLTDPDNKIGVWFILQDLSVRTEGAFRLKMNFVNVGRVDGGGLNTGSAPVLASAFSDVFHVFSAKKFPGVIESTGLSKCFATQGIKIPIRRDKGDGPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZY7</accession>
    <name>A0A2T6ZZY7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1106688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZY7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZY7"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="639"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="855" mass="92971" checksum="A33940E4F778FE95" modified="2018-07-18" version="1">MSKTVPRAAAAASTSADPEVPRPKRIACIVCRKRKLRCDGSKPSCGTCARLGHDCAYDEIRRKSGPKRGYVKALEARLAQVETMLKDQGPAADTQQSLGGNISFASTQLVDPPIYSTGDPTTYTANKDDGSMGLGERFTLGGSPSQSQSPFASGSPSLLHMEMGMPPMMGGTPHTAPLNWDMMAMGLEEALPAPDIIDSLHRTYFEKIHPCLPVLHKGRYLAALDLAPNARPPVALRYAIWTMAASVSEEYSNLQTHFYRHARKYIEDCELKGHGESIISVAASQTWSLIACYEFKLMYFPRAWLSTGRAVRLAQMMGMHRLDGVGLDVKQCLPAPKDWTEREERRRTFWIAFCIDRYASIGTGWPMTVEEKDILTNLPAADDAFDQGRPSKGLSLKEAMTAEGASLLSPFGGVCLMACLFGRNLIHLHRPDGDDRDDDLNGEFWRRHRHMDNILLNIALSLPPHFRLPGGIADPNIVFTNMNIHTSTICLHQAAIFKADKNRMPATVSAESKIRCITAAAEIASIMRMVCHLDLSGMNPFISFCLYVAARVFVQYLKSRPSDEQVRSSLQFLLTAMGHLKKKNPLTESFLVQLDVDLTGSLDTPVNNSKFPYGLKKGQAELYVGRSSGFYCPNTAEALPADKPRSSASTTSPNPQSQHSQSSSLLDDPPSYLRPDTDVLDGDLANMHPSCPCMPHEIRAVLERRAKTTPPTRDLAKYLGGILPPICPCMSPEVRAYIEASAKEAGAQPEYVTHSYSNSSDNGQSPASINHSDHSQASGGGPHGGGPSSDGYSPLLFEDIAVDMGGGAGAGSGSGYPLPKDMNWEMLDLDPGFDDGGIGSMPPGSFGEYFAESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1D1</accession>
    <name>A0A2T7A1D1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear pore complex assembly-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1113300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1D1"/>
    <dbReference type="STRING" id="42251.A0A2T7A1D1"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="42"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="323" mass="36495" checksum="9F5EEDD52F4278F6" modified="2018-07-18" version="1">MDLDRSSLAIYRSIFPDDKKFPYTRDRTGQIARHRSLLDGSLFFDYVLREIASIEDVDRLYPPKNVAALRALVTTIMDKEELDKLKRDSFIYYLKKDFDYAHPGSDDAGSYSRKALVQPNFCTLMDGLWALDNFRFEEAITHLAEPAVTPINPHKILSALIHHAGPTLGPRLATTFVQATQTKLNTDDSIRDYFTALRATSIESAFLYQRTVPESLQQELFISLIDHCLTVRKEVNALKLINLPFTPKEQQMFENHICHSNLPAAQDTLIIKQMHQGQLDEAWAAAKSARYQNEPELGGLNWASLARGLASGIGPRAANEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A246</accession>
    <name>A0A2T7A246_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A246"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8600" checksum="A6E557E6FC54A958" modified="2018-07-18" version="1">MPGENGQPPLVPSHYNSIILIARVNQLPKSNIRGNRNPSMREMAQSEHMWEVQLRNLGGLNDMHFDPKPTARIAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2E4</accession>
    <name>A0A2T7A2E4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2E4"/>
    <dbReference type="STRING" id="42251.A0A2T7A2E4"/>
    <dbReference type="OrthoDB" id="5276978at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35559">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35559:SF1">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015564274" description="Chitin-binding type-4 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35892" checksum="1EE025D83725F71B" modified="2018-07-18" version="1">MKSFQLASLISLLAASASAHSWLECVDTQVSNYDAAKANPSLDVQQTCNGYPRNKVSNGDWIQESQTYLWDLNNVSLNPDGLACRPSQTNTYPAGVPMTTARPGQNLRLRHWGNGHSRYDMGSPLHKDPGVVRLYHAGKKETDLKLKSDLVEQNWVRGAQANFSADAIIQITGNQMNEKANYFDWTVPSNLEDGRQSFIWVWAWGPAVTSNSANFNPATDYNNALLNSWTTCFDIMIVGSSATTSADTAGSSGSSTPSTDTCSKTCLKGGMAQYPCTGSDCPPCWYVSGGTTNCFEYGKDGTCPFGGAYDCKKNIQTRGATRFERTPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3E3</accession>
    <name>A0A2T7A3E3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1075595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3E3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="8716" checksum="17840B45A2794B3C" modified="2018-07-18" version="1">MISPRIRQSRGTKVCRRPIYDANPRGFWCRSGKEGAGKARRPIEHIQHMRHRYLVPKDLLRANAREKTIISLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A425</accession>
    <name>A0A2T7A425_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_968081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A425"/>
    <dbReference type="STRING" id="42251.A0A2T7A425"/>
    <dbReference type="OrthoDB" id="2289094at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18870:SF9">
        <property type="entry name" value="PROTEIN TAG-278-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="693"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="771"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115574" checksum="3DBC30E6903A6126" modified="2018-07-18" version="1">MSALSNTATTGRASVASTARENAISPRPPSAAGRPISAAARGATGISHLSSRPSTSTLRSRATGPSGTLSASSATSSKELEALKVKVSDLEEKNKELSEQLSKAGGHPTTNGDAKTATEELESELADLKARITIIQEANEKLQAQCKEFAGMAEESAARVRDTNDEINARHAKELKTLEDSFGVKEKDLLAQINTLKTSFESLEARHAEEVSNSTSLVEKAATKTGDLQKTVEALNAALTAEKEANSQSSIDTEGLVKRLTEEIATLKKQIEDAHEASKGDSEKNTEALESRQKEIDSLGSVIKDLQEKLEKAALESKASEEAIQELQEKHAAELAEAVNTEKTVAKEAEAKLEKLIQEHREQLEKGSEVLSAQLQEAKSAARVLEEDLLQKIEAAKLESAEALETTQQEAANQIEAVRQENEAQKKQYELTIEVLKKEASGTVESKDKEWESKIDQLTKSNQELVDNLTAQLGTAEEEIQEASRQLELVKQQSGAEIKSAQEQGKEEVAALQSTLETLNKELADKEGQLAKLKADFEKAVEDMADSAETASKLEQAHKVALDSQRAEHVAEIEKMKTELTSGNEEKYTLLSEKYEALVAQLDSTREAHAVEISRMAGELKGAEESVAELLQSHSSTISSLEGQLATEKASRVELQAALDAVPDQSAFDALSKHLEMAKAELDQIKTSKDAEIKTLQESLQGAEESKSRLESEVAKEKTLNKELLEKASVLEMEASEAKKELVEKSAFVEKSEEEVKDLRASMEADYKSMELIYRAEADDLNREIKSLKDKLGAGESGMQGKDGVIEKLESERKEIEATLAGLEKEKEALEEEKAALVGENGSLSREKEEKEASVTSITAELESLKGELNVLEKEKETALQAVKAKETDLEKTNELVSSLEADSTEKSNSLEIITKEKSDLEAEMKQLKVQVDSFEELVKAKESAIEIAIKDSEGLEATLKEQLGAAEALVKEKEAALTTSQNESAVKMRVIEAELAELRIKNKHLLQELSATQSLSANVAALKQQLGQLQADNEEMTRENTRMLKMIDNLPPGPTPDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4D2</accession>
    <name>A0A2T7A4D2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1074503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4D2"/>
    <dbReference type="STRING" id="42251.A0A2T7A4D2"/>
    <dbReference type="OrthoDB" id="5323643at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015768902" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="14964" checksum="F446FEAC414927E9" modified="2018-07-18" version="1">MQANAFLSYLVAAILAVGAIATPVGVEGTTDVNIVFENVANSASFGGGAPPDPRPIEPILTPKEGDVPAPSNTSVVAGGMVSIKPSSINLVLPRNISSFSPDPYTFCKIFTGPNCSGIGSVMFGSPGYGNLGIWDNNMGSLECWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4N7</accession>
    <name>A0A2T7A4N7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4N7"/>
    <dbReference type="OrthoDB" id="10504509at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="562" mass="61763" checksum="9D52EE77F6D0904F" modified="2018-07-18" version="1">MSWGTENSFSSTCRLPSDDTSTSHPALMGEAFSDLSRVSSTDEVQVIEISSYSPDVYESQLSCAPDASAAMNEAGREERFEAELQDAKHQEDDNEDSDIESTMGEFGLKYNEDSDAEHESDDESDGVSEYASPSDEQPEPMRARNRSGPPIPPPVPVRPGQLFFSNQIWTRLNVEQQLKLGALKVGSKNKSFKTRPWLVVEKSDRVDSDGQQMLWVMCCTTRNRNGWEGVSYRDSKSFIPMAPTPSRFGRPVLPLVADDREVFLGGSLLFLEVFKEIKPSLLGDYIGHISDESVSIVNREQRRIAEERRKKEELRVANTAAFKGRGGSHRKANERCKLRAETRFDQSGNRRNSCSGHQCGNDEGVTSGSFTPFQLPPCTNGTQVSPPLNPTAPSFCDPTAQGNRGNRRKSLSSRGMQNRQQQNNRRQNYSSFNQTMDSGNPSPQTYGGRVNYGNFGGYSSPGSYGGHEDHGNHGRRRSSTGGHGGYTGPQRNYGGRPNSGYFPDNGYHTGRVASLTRDGGQPTSHASGSTGHPSGNIGNGWVSGGFGHGGPSWTATRQYQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4R7</accession>
    <name>A0A2T7A4R7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4R7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="7972" checksum="2036FA1CF099967F" modified="2018-07-18" version="1">MSAKISTTKRPATASIPYLNAVSSAVQGFPPTPPSPTILFISHQPPENLQSVKMTYHLFPMGQARLGHSRNVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4W3</accession>
    <name>A0A2T7A4W3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1152771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4W3"/>
    <dbReference type="STRING" id="42251.A0A2T7A4W3"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="47"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="551" mass="61085" checksum="37B1A30ABBA55AA9" modified="2018-07-18" version="1">MASSSFNAGDCSARPEQRFTGESGSIKERGSLPPSYDHTHRKLKPRHIQFIGIGGTIGTALFVSIGRGLMQGGPASLFIAFTLWCTVILGVTNSMSEMVTYLPISSPFIRFAGRFVDDAFGFAAGYNFFVFEAALVPFEVVACNVIVRYWTDEIHVGIVIAVILICYAIINIFGVSWYGESEFWLALGKVILILGLIAFTFVTMLGGNPLKDRYGFRYWRDPGPFAENIKTGDLGRFLGFLACLIQASFTIAGPDYVSMAAGEAENPRVVLPRAFKAVFYRLTFFFVMGSLAVGIVVPYNDPVMAAAFKDGKPGAAASPYVVAMDRLQIRALPHIVNALVLTSAFSAGNSFVYCASRSLYGLALEGKAPRILAQCTKNGVPVYSVAVVLAIALLSFLQLSNSAAVVLQWFVNLVTASQLINFSVMTFTFIKFKKGLEAQGISRESLPHKGFLQPFCAWYSFTATTLMCFVSGYTVFLPGNWDIPTFLFSYLMIAVVPVLFIGWKIIHKTRWRRPEEIDLLQDKDEIDQYERDYFPPPPRNEFMKYWDRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5J6</accession>
    <name>A0A2T7A5J6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1073639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5J6"/>
    <dbReference type="STRING" id="42251.A0A2T7A5J6"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000269">
        <property type="entry name" value="Crooked neck pre-mRNA-splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="366"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="80683" checksum="DE70B125A3935C81" modified="2018-07-18" version="1">MEASRGPPRVKNKGASTQQISAEQILREAFERQEQGLQAPTQRFADLEELHEFQGRKRKEFEDYVRRNRINMNNWMRYAQWELDQKEYARARSIFERALDVDSRSVVLWLRYIEAEMKTRNINHARNLLDRAVTILPRVDKLWYKYVYMEETLGNIPGTRQVFERWMSWEPDEAAWSAYIKLEKRYDEFARARAIFQRFTQVHPEPRNWIKWARFEEEFGTEDNVREVYTLAVETLGEEFMDEKLFIAYARYEAKLKEYERARVIYQYALDRLPRSKSQLLHKSYTTFEKQFGEREGVEDVILSKRRVQYEEQIKENPKNYDVWFDYARLEETLGDKNRVRDVYERAIANIPPTKEKRHWRRYIYLWVFYALWEEMEGKDIDRTRQIYNECLKLIPHKQFTFAKIWLLKSHFEVRHFNLPVARKTLGQAIGACPKDKLFKGYISLETRLHEFSRCRTLYEKHIEFNPSNAQTWIRFAELEMALEDYDRVRAIFELAVDQELLDMPELLWKAYIDFEEEGGEFDRVRGLFERLLEKTDHVKVWISYAHFEVNADEGEDEDTVSEETKARARKIFERAYKRLKEKELKEERVALLNAWKAFEQTHGTLEDQKKVEAQMPSKVKKRRKLDDDTYEEYMEYMFPADEQSNARILNMLQAARAWKQNQAGSGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5M3</accession>
    <name>A0A2T7A5M3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1098881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5M3"/>
    <dbReference type="STRING" id="42251.A0A2T7A5M3"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="669"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="733"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="751"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="820" mass="91763" checksum="2F85DDBEF744E72E" modified="2018-07-18" version="1">MASVQHTTSPGQPQALHQTNGHPPQSIQQQQSKPTAFQQLTQVNEAVWLQIGSVTELMGDLDRAMAAYENALRQNPYSIPAMNSISCILRTKEQFAKAVEYLQSILNLDGSNGDIWGSLGHCYLMMDELQKAYSAYQQALYHLRDPKEPKLWYGIGILYDRYGSLEHAEEAFSQVMRMEPNFEKANEIYFRLGIIYKQQEKYRQSLECFRYIVADPPRPLTEEDIWFQIGHVYEQQKDYTSAKDAYMRVLDSDPNHAKVLQQLGWLHHQQSGNFASQELAIEYLEKSVSADNSDAQSWYLLGRCYMSQQKYPKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWYDLGTLYESCNNQTNDALDAYQRAAELDPTNQHIKARLSLLRNGQSSGVQHQASAPPPQDVHPQAYQAAGVGGPPGPQWGSQAPQAPPPAPSGPPPTLPQIPQPPNPSSYRPTDVPPQPPQPPRHMAHSPDDLRRPVEDSRHTQLRRGLSPSPKFPNHSPHTSYPPPSLQGPPPQQQSQQQQQQQQQQPPPNRILNPHHNPHILPPASNNPGGISLPPYGGRGASPPPDVKPIVDDRLSSPNTYPHHSHHPPSQGGIAGGAPPPASAAMAAEAAARERDEKSHHNKRAREWDEEEGQGIGKKPASEETRARMDDMRHHRQSPPVRAPSPHRPERRRSSSERPREDYHHGPPAPLHTPNVPPLLGHQPLPPINDAPRMSEPPPRIAEAHRMSEAPRDDRKEIIEPAARKVELDEDYDNEEMGDADRNPSVQVKENNSPVGNGTNGISGGGAPGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A719</accession>
    <name>A0A2T7A719_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1060851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A719"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="137" mass="14931" checksum="477F77844A6C65F8" modified="2018-07-18" version="1">MGGEGLGWAGLGWAGAGLAIVSFCIIISFLKPPHTYHTSNPPQVPHNIGARPTSLLVSSSFKLFLSSLATLLASSQRQHSYVYRTTKSHTRKSHTNSHSTHPHEAPKPQSQKVPCHMIRYDTHPPGPTPLENSNEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7F5</accession>
    <name>A0A2T7A7F5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7F5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="62" mass="7051" checksum="0A7D9B4AE5AC5574" modified="2018-07-18" version="1">MSIPNTSNRNPVFPVTLPQLKQTSPSQTVPPKPNSTPNGIEKHARPRPCNPRKALLWRLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7M1</accession>
    <name>A0A2T7A7M1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_787241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7M1"/>
    <dbReference type="OrthoDB" id="10505788at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015680789" evidence="2">
        <location>
            <begin position="27"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="382" mass="42305" checksum="13A189371A5DB8C7" modified="2018-07-18" version="1">MKFGLCSPKIALALPVLGALMAPTSARPHPLTKYRFRPEKTSLELDLMPERVKNPLFHSEVPVELKEDTAVPEPALVSNQQPDDDVIDHVYNHEVRPLHSVASPTENHYNASENAQVEGEPYEVEDIAPIEKRDVLPSLTGEDEEFTQSVQPAPSIPEEEQQETQAELDDPVSDVESDYYYAHKNGEKQPRSTKLVEGALRHTAEDSQRGWKKSPNEGLEEDLVNAPHRKHVAEPTPAAGPHEPILDHFDGYVEVPITPDNTTTAEDIDNVDINAYTLNRFGRTPAITGDTSDYAVSADLLPEALLHPKEEEEEEDPEQHIERRAAHRLPIQDIEADEADPAAAPEPSATEASPEVPFSDNTGTAYTSEEGQARFGRPVIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A848</accession>
    <name>A0A2T7A848_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1118639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A848"/>
    <dbReference type="STRING" id="42251.A0A2T7A848"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="575"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="751" mass="84699" checksum="CFB5B8EE885299A3" modified="2018-07-18" version="1">MASALRGTTSLICRSCLRLLRTPLQSRLVLVSSQRLFHTSPRRRAFGEEAYPNTPSALSEAATPPEGLPEGAPHIRPLFNLPSTRQSPLRLSRQDLARLEKHLEERDLPGGYATWLEISDPKYRNGEPTSEQVTDEAIKPVVELLLEGLIEEGPRHRELPPAAEFLEALRSMALANDSQYRLLLTSMLQQGKDPELVAPVLDSAIQYYKEDHFKTGARRRTVEGGEEMSDIDRDMLWSSLRWGFRLSNSPSAIASTIYLAFLHTMEVATQHHKDLERTLFSFFQLPNAVFLGKYMAHHYFEEEMRMRLVKLAEEFEFRKLLTVPTLLQRATAQYKDGGRLKEYYDSLRTQATDFSIPFSEENFMVFVTAFMTLAEREVAIEIWNDMARSGIFPKPRSWNLLLTEAGKLQDKDRSCLQAVWKIIITSGVIPDVILWTTRIHALLMADRAKEGMKVLKDMQDSGLKPTTATINAVLDGLLKHQHMDEAKKTLLVAAKMRIKSDLTTYNTMLRALLRSKMFNEAISLLKEMQAAGIDADIFTATTVLDGLYKSSPTKPDLTKVRNLLEYMEAAGVPANEVTFTTIIEGLLGTGNEQAAQDVWKIMELKGLKPTPATYTTVIRYAFSKGDLLGVEKLWQQVEVNRVPKDQKLWTRLAVGYAQMGEVERLRSVMAAMEEENRTLPLSAYTLIMGALGRGGLYNDVKDIVKDALEKDMIFSDGSARAPAERIFWQTLEKMAEGAVLMDLKAQGLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A859</accession>
    <name>A0A2T7A859_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A859"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="7732" checksum="BAC412AAEF251467" modified="2018-07-18" version="1">MAAAVLVLEVGVRDSTALVPDTESTTLCKKSLQGFALKPQIECSVCVLHNRQPAQIPPTKHYHTALNPKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A872</accession>
    <name>A0A2T7A872_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1189325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A872"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="53" mass="5767" checksum="8ACD194C230E2D12" modified="2018-07-18" version="1">MPILEAKFICLALGGIVDKNFSLYNALAFLPTFWGLFTLKERGGGVGRGFSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8C3</accession>
    <name>A0A2T7A8C3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8C3"/>
    <dbReference type="STRING" id="42251.A0A2T7A8C3"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF1">
        <property type="entry name" value="VTC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="765" mass="85499" checksum="3B1B836FC004A19C" modified="2018-07-18" version="1">MGLPLLTNTLHTRALTPCIPRRITPRTRAMNHNKYLLPTNSTRRIPNDHPSTSSSSRSSLPISVSPSPSPPPQLCLPAAAVPQHNVRAIRAPPREWPPIRYQTELSTAEAKQFIGDGAPKFRGELREITNGPRGHYYLFAFSGDEWDEESDTAPFQSDSFCDMSSSPEGKQTDALERPAMAHAFGIYPGTLTLSYYVASFGSTLQGPQVAARGKVRKLTMLYVLDRLRILQVRGIEEDLEQLHVHLYDQLLHDTHRYDSKISLDNQISDLVAALCRPSWVNFSGPENQTIARFLSDPNPGVANSFFHQLLLSIELYLRINARHQTNLAMKPLPDMPEKIRWDLMLAQRWLENVEVEAPKKVKDGKGKREQKSSVGFKFPNKKTQVEALRNFAWTLKWPNMHEVEYTLSEDEDPNEVLEDKSINCMSWFTGLLLPGKSMPWILMNALTDCDPDVPETFHNLSQTTPNVGFQYRGHTYWSWECIVGKVLGAAAGVAQIAGWIGPCSASADLSRSEMAIINQMPPRGNKITPSNVRSMVQNSDPLGAYQSTYPVDDYVLLTPNTDDPVEDIRIERLNFSQAASSPKGVHRITENGHQAAEESPVLMFDASITFAITVEHRTRSWKVSLRHDTPFIAAYPCQNGPHVLFCEYQHRVIYADKLVEIQNWGPSGGVEDSEAEDEGGQPENTATGVEEVLVVEAFGVPDNEVFARAWCSFWGLSAITADVNKTCMACAIREAYAALVSVVILTNRSSIAVEVEEVDRLMENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A993</accession>
    <name>A0A2T7A993_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="9">FBP aldolase</shortName>
            <ecNumber evidence="4 9">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1098103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 9"/>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A993"/>
    <dbReference type="STRING" id="42251.A0A2T7A993"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU84299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="31833" checksum="6048FB34FDF32D41" modified="2018-07-18" version="1">MGALDVLTRKSGVIVGDDVLDMTLAHEFLTRSRTYITSSTVVAALEAARGAHSSPARVYPTATKRSIYCTRYQNPAILDTHEPLRKEAPPLARRDCYPQRKHTSPPTGNHLLIGVDNTGVDNSALYCTQPEDIWEVYSITLAPGSLYYSIAVGLRECGGVYKPGHVRLHPELLGKHQESTKGKIRVEGEKGKKEEKPLFLVFYGGSGSTKAEFEAAIGHGVVKGNLYAYSTGIRDFIRKLSIPFLLYLPTHTRPANNPDPRVWAREGEKTMCARVKEALHDFNTANQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9B9</accession>
    <name>A0A2T7A9B9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1098119</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9B9"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU84320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="326" mass="36509" checksum="7809F9A1CB0304C8" modified="2018-07-18" version="1">MGDVDFNNLPPHVQSHFRDSTQSKSPGSDGASPAERSEGSSSRFNFEFLKIGSSRNKDGEKPKRRGPKPDSKPAMTRRQELNRQAQRTHRERKERYIKTIEEEVARLREAFTVITREKTAMMEENRRLRAILDAHGIPYDFQNVSPNVGQQPRHDEYQQAPEVARFGSTYDEIGIDFVLALEKPCMDHIQILTTSAMTNSTSDFHGHALMASCPSESHVLRHAEIPWSSKTLDVGTSELSVLFNLSNRLELDGELTPIAVWALVTRHERFAELEIADFKALEATLLDKVKCHGFGAVVEEYEVNDALDGVIIKKFGGGEGSGSADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9D7</accession>
    <name>A0A2T7A9D7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1104530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9D7"/>
    <dbReference type="STRING" id="42251.A0A2T7A9D7"/>
    <dbReference type="OrthoDB" id="5351126at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="558" mass="62140" checksum="1D27A7FAD05DD856" modified="2018-07-18" version="1">MNDSAAHLRVCYWYKFRARGLPRSSGRRSMLGLLRLGGNFRDRKKPQAKKEKGKRKQALKPNGGRQGGLVIIFGLVGQQSSSALGHLLSQLTVCGYDGYFRGLNSVGSTLNLWDICPRVPYADGGRKLLSPGLIRGVVAAAIAVVVPPTSQCPTRSIYLYTDPRSLSAEAGRPVKKHQPNPPISNARLLTSPEPAGPAAPQSTQRAISSLITPYLTLKPVKRTSKKSTHPHRLSSSASSIRSITSSILSRKRKYYYEHPKLSTLPSEILDEIFQHLDQGTLLALTKVSRRMFDEAAHTLYSSPSFASTYRFAQFVSVVSQNRFLARMVRMLDLSNLGSCVDPDVPLAGWREWKFRSSQLFTIHRDDRGSKRSGQRKSKPAVLKTSTHPLPSPLLKQYSTSRDVPVGGIIHVLRACSYLHELNLSNVQLAPDYSVRWTKTSTYKPVAFTGLLFVSDVPKSFTWKEDDTKPLHASVDLVEAILSLKCLQGLKIKGGLWVSRDVARRIVEKSEKLGKVDFRECGMYKDSCWAVEGQKDKIKKVIEEELQAELRKRQSTASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9G4</accession>
    <name>A0A2T7A9G4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein prenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_960671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9G4"/>
    <dbReference type="OrthoDB" id="5358702at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU84381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36923" checksum="60C75396449277AE" modified="2018-07-18" version="1">MASPTPAYTQLTAFFNSNPGTRLHIEFHPTQPDTSPTTLTSGTNIAIPKPLLLQAFQTAYLTFCSSNTKQDILDSTLVLLLVAPENLTAVNARRRIILGEGANDGRDEIKLMESFLTSPLNKHNKSPLLWSYKRWLTERFGVLEKGIEAELAVVEASGEVHPKNYYAWNYARFATTFFLPRSPSGPQLPYILERTANFALSHVSDTSVWSFLQFLFFQALEHPDPHSFQVQLADIVEKSMQFAHGIARGHESIWVFVRTVLESGELLDAGKRVELVRVLEGWVRGDVVDVEEARRERSLEERALVWIGKHRRGGGEGLVGLHTVNRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9M3</accession>
    <name>A0A2T6Z9M3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1097898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000684">
        <property type="protein sequence ID" value="PUU72183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9M3"/>
    <dbReference type="OrthoDB" id="2134400at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="118" mass="13536" checksum="444B0C669EB1683E" modified="2018-07-18" version="1">MGKSADEILKVNAGFKDAKYLNCLENVGRNELEGNKFRMAVIEESEEIKIDSITEDVRRLGEVMERKDARGGEIIMIEILVDRSDLWIKEMAGQHKATHQRDLAKAVIRHFKNLVVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9W8</accession>
    <name>A0A2T6Z9W8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1138266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000600">
        <property type="protein sequence ID" value="PUU72287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9W8"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9W8"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="346" mass="39562" checksum="09A49BDE986A8E32" modified="2018-07-18" version="1">MRKFMIDQSQVDLHLTKLKCQLSAAAKQSIFTWVTAYNKYVSSFFINNFCFLTAQCFGQEYIDTEKVLRTFREVLNAPGRPSGVLVPVVHMGRPGSTRIDHRDQNPPWWTRRAVDIFLIKHNFDIAVIPEGWFYWPMCMGRLEVKNPLIVSNSVRRELCKNPTKKLKEAFETEEIKYTVSKERHSTNSLTIYYFLSYLLSEPPSSTVLMTKEVEAAVKNISQGARKLTGKEGSPRIAVLASLSNNHDSHKLLSGSADPLFIAMTKDIPENSKLVFTTPDHLAQVIARADKPFDIHRGCYTLMTSVPKEEMEDDGPIDQAFYNLGRRNAVKFCYWGQERSLIITTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA63</accession>
    <name>A0A2T6ZA63_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1137875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000561">
        <property type="protein sequence ID" value="PUU72363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA63"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA63"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="550" mass="58093" checksum="2A4CA7E4C882B8F5" modified="2018-07-18" version="1">MSQSSAASSSSLPPSSQIPLPDYYEPPQRRLSTPSSQMTPHNISHNPPPLLTHSASNISQASTVFSMPEEDDERPPDSPSSSSHGSPPLVSTTTTPVVPPSGANPQCNPFPASPSVAVSTAGSKRTASGTVKSTLLGASGPGSPATPVTPRPARIHAGIDASPRDVSQISTTLRTRLTYALLKVENNWTTESIDQIEARVAQGQYLSSSPSPRVRIKREPSIGDDQSSSLDSIRRHTRTNSEPNTAHSISAGSATGRTYEAFWKNHRPHPAITKNLKAKAASQALGMSTNAHTPQPTTPSSHSSQRSGSGLQPPAQIVSDRDRRSYYNPPRNPPTLTTAGSNLSNYSTYSNASMGSMGSIVANTPPPLVAQRSMEQDAVESLMFLSSPGNSRPSSQQTISSAQNSQHSQPPVATFLPSPTQPPSRAKHNYARNATTWPRDRPRHKQQRTGLEGLGVTIRRSGVDEDEDDATDEDIGPDSVNERVKDGRSVGLKNRGGRSTNISPVEMAAEVARHKGDVGNASSRAAGTVNTGGGRVRMGASSSSAATIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAN9</accession>
    <name>A0A2T6ZAN9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1137269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000506">
        <property type="protein sequence ID" value="PUU72562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAN9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAN9"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.200:FF:000003">
        <property type="entry name" value="DCN1-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="26670" checksum="1062C90B51BD9951" modified="2018-07-18" version="1">MSRRFNRYFTSNNSSSTMPSSADPALRKVFDQFREPGDPEDTMTVNGVMKFLPAIGVGLEEETVLVLAEALKAPTMGEFTREGFVEGWKALNCDTLEKMRAKVPTLRASFTNDETTFKKVYLFTYNFARSPNQRSLQMDTAIEYWKLLFTHRFQKNLGDWIEFLETEYKKSIAKDTWNCMYDFVQFADKDPELRSYDVDGAWPSILDDFVQFSRRKNGTEPPPQEEMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAY8</accession>
    <name>A0A2T6ZAY8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1009031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000500">
        <property type="protein sequence ID" value="PUU72584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAY8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAY8"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015575358" evidence="1">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="72" mass="8500" checksum="CE364E49FE89402B" modified="2018-07-18" version="1" fragment="single">YQWLILVFVPAGCTGIFQPCDVGLQRFYKHHIKLEAAESFQKVVWNQLRDEILPRDIKIGENIRQLRNHTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBC8</accession>
    <name>A0A2T6ZBC8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="5">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="5">EF-G2mt</shortName>
            <shortName evidence="5">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MEF2</name>
        <name evidence="7" type="ORF">B9Z19DRAFT_1136717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000466">
        <property type="protein sequence ID" value="PUU72783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBC8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBC8"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04092">
        <property type="entry name" value="mtEFG2_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="55"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="852" mass="92908" checksum="F884135C323DFB89" modified="2018-07-18" version="1">MLLPARTASAIYWRYLPLPKTTPSLGRTILSLQNSPKRFYATPSATGANAPVDLAQTRNIGIIAHIDAGKTTTTERMLYYSGFTRRIGEVDEGSTVMDYLPAERSRGITITSAAITFNWTPSTPGSQSYTINLIDTPGHADFTFEVERSIRVLDGAVTILDGVAGVEAQTEKVWRQAEKYGIPRLIFVNKLDRVGAKFGPTVKEIASKLNAWPAVLQLPIYEQDTKGDDIFRGVVDIVEKRVFIWGLEGDGQKIDMYDYTWLKGNRPDLYSEALTARAALVELLSEHDEELVEVFLDIGDHHAISPGAIKKSLRKQTLRGSSEVVPVLCGASFRNIGVQPLLDAVIDYLPSPLDKPETEISYNHGKARGVLNASEDRLCALAFKVINDPKRGAMVFVRVYSGTLVRAHHLYNTTLGVKERVHRLLKMYADDAIDIQSIPAGHIGVIIGLKNARTGDTLISDHQHHFGKGNKHHQKASDSFGTVQLRPIEVPPPVFFASIEPNSLSEQKPLEDALSMLLREDPSLHINIDEDSGQMLISGMGELHLEIARDRLVGELKAKAEMGRILISYRETIPSTSGYELRTAFEKEIAGKLSKAGCHVSVIGLDEPPILDPGTPDETVVDGNLISADIIAPNHTLTMDEAEVEHTKLPKSIDTEELKGSLISGAIAALGRGPYLGFPVRNSSIKITIDPSKDYFGTESTLAAYSSAARLAVTMALKEAIASNEEGILMEPMMNVIVTVDEKDLGKVVGDLSSARGGHVLELGGGDEGGVERLDTSKVYAPGQAGKVDDNDGGVRGKRSVVATVPLKEMVGYLKHLRSMTTGRGTFVMNLLGWERMTRLRAVDVLKDIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBM7</accession>
    <name>A0A2T6ZBM7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1136436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000447">
        <property type="protein sequence ID" value="PUU72883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBM7"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="268" mass="31345" checksum="2B5BC35DD7D20084" modified="2018-07-18" version="1">MRFSKSPIRFAASVHIGTFRHPTDRVRTAFDRCRGQTTNHVQQRDAPLISMHDHHVALRNIEAKWLKLTVEQRVFWGKQDAIRYREQHAELSQHFKDELKLLQEPQKALINDLFEQKEQDQKRIQQGIIRNCDLLYAALKERTEKMMVLGNCNLCGALERMVYLAKLEEKIPPTVGVQEGLDKLAQRSEFTEVLHKEVQARKLVVEDVMACLNHLYDKVCKRTKEMEDAMVVVRAARYTDNERAALVVLLKLQDNWLDPLDWIEDMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBR7</accession>
    <name>A0A2T6ZBR7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000447">
        <property type="protein sequence ID" value="PUU72886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBR7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="22467" checksum="E387FCC6EC4A49E5" modified="2018-07-18" version="1">MYQSHKMLSVLRFNRTYIEGLCFIQDRDLVPSASHSCCFYEGNTTSPPPVGPNSVLCYPTRSPISLYSHKGHLLPQCPTLRMDKPESRTVSSGPDHPNCSVESTEKSPQQSQNGEVGMVEIETRPSAFDEGVKFQEATMTKVDTPDTSGEVQKKDNEDDRSNIPDSEGSLACITNQNMDHDEDDDEDGEFGDEDKAVTDSLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBU7</accession>
    <name>A0A2T6ZBU7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1136386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000444">
        <property type="protein sequence ID" value="PUU72916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBU7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBU7"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15893" checksum="DA987D387A7366DB" modified="2018-07-18" version="1">MEAPYMDYYSAPQLMNRFTDPKSTIVVVSRVSGYVTEDEFPSRFQGFGRIFMLRFLRGKAVDSFSLSRDMRLRCPHAAHIDPPPQPDRTPPLRPPSAIPRPINPAEPLNIYHMNTRYLAAKTGRINRLEAGSRGSQSVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC44</accession>
    <name>A0A2T6ZC44_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000431">
        <property type="protein sequence ID" value="PUU72984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC44"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="10064" checksum="C72127310EB243CA" modified="2018-07-18" version="1">MFILRNNVPPLRCGGREDGRRTGGSDIIPVPVPSPTTDKRARSPSGTSTGHNLPTPGPGILYAQETPSFIHPSIHPYPYPCPITNIHQKGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCF3</accession>
    <name>A0A2T6ZCF3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1005793</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000407">
        <property type="protein sequence ID" value="PUU73170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCF3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCF3"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="474" mass="51102" checksum="C57A21AFA1E84FCE" modified="2018-07-18" version="1">MNNHQRKRQHAEVNEKHGGNYAVDDEKLNDGDGTRAGALEGSPQPGSQQGQGKRKRVFSNRTKTGCITCRRRKKKCDEGKPECFNCKRGGFVCEGYSGKINWQKPPGRSTNTAGAPVSIQSKTEQAGSTSASPSPAVVQKQSQTHRLDEAVQHQSPQTRVVPYPYVVTTPIVVPEKQISEESTSPNTVELPTPHTSSVRAQIPQPSTLPAFVPAVPQRVTPANNTVTSHRASVSQATITAASGSSVPHERSEKEKMIHSELYFASSPELVQERERCKAACWRFNNAATNPDLGISKAEKGRLLHQILRPGTTWEATRVNGPAGPEVSYISDTGTTSDIVDAHIDAPFNCSYGYNIRLGRDVLIEAGCTILDSCSVTIKARTILSPDVSIYSATHPIDPRKRNGSNGPELAKPVIIEEDCWLGGNVIVLGGISIGKGSVVGAGSVVTRDVPPYTVVAGNPARVIRGIYRNDNTDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCI2</accession>
    <name>A0A2T6ZCI2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_568481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000403">
        <property type="protein sequence ID" value="PUU73200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCI2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="61" mass="6521" checksum="F4A17F3DE4F490E6" modified="2018-07-18" version="1">MVRGHVSEKAIQANLAVIIIVLVCVSMDARSRMESRGKSVVVGIVFLLVSCIAVVSVSHQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCZ5</accession>
    <name>A0A2T6ZCZ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ER lumen protein retaining receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1004904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000383">
        <property type="protein sequence ID" value="PUU73367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCZ5"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU73367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="307" mass="34814" checksum="F41F8BC4047FE380" modified="2018-07-18" version="1">MNAYRLTGDLCHLASKVILILTIHLRKSAEGISLLTQMLYALVFLTRYTDIFNPHASAYVTIFKWTYILTSFYIIYVMLRVFKRSREEEREWRVAAAILAISFVFAPICWGLKEVIWKETKRGDWVTQIPWTFSIILESLAVLPQISLLRYTAIPTAITSYYLLALGIYRALYIPNWIVRYNDPEDHFFEPWAVVFGVLQTILYVEFAWIYWRRQRVKIRDNGAILDGEDFIAGGLILRWIGKLGGKSGERTTGGGWRGRGAGGGGGISVSADEEADLVGEEFGDSDEDDEDEGLESESGSEGAVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDX6</accession>
    <name>A0A2T6ZDX6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1068798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDX6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDX6"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="364" mass="39156" checksum="217C6718F1DBCE9B" modified="2018-07-18" version="1">MPGASSNNIELKSDLEAQKANLLSRQGDDSDDGLSLSGSTRSSLSGHEPKPATLPDGAVKSNPQKSSQTSFLIWTTVNTLATIGIVFTNKKIFDDPNFKKMQTSFAAFHFVCTSLTLLVISRPSFGFFVPKRCGIVEILPLAFAMCFNVILPNLSLAYSSITFYQIARILLTPFVALINLVFYRVSIPMYAALSLIPVCTGVGVVSYYDTRATTPEQQGKVTTVAGVIFAFSGVVASSLYTVWIGTYHKKLNMSSMQLLFNQAPASSCLLLFFIPFADTIPVFSDVPFSRWAMILMSGLFASLINLSQFFIIAGAGAVSSTVVGHAKTCSIVILGWMASGRGIVLAIGGIIMYSVAVLKARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE53</accession>
    <name>A0A2T6ZE53_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE53"/>
    <dbReference type="OrthoDB" id="5429277at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="26756" checksum="BE16A27F83C4D470" modified="2018-07-18" version="1">MSEDYIAINPSNTSSPTAGAAGNHATGSYSKFPLLDERTAAILVAIGVPLSFLPTFTLRTWHFPLHKTTLNDVSADLHVGPGGKPGGRKNRKNRRNRKNSKNSNKHPVAKTTPLRTSNRVGKNKKNSATATASSGSARKSPPGSGKRKRAQQRDRDRKRSERENVERKKWLEDWFDSENKRKEEQAVDGLVELMEGFGICAGDKGQEEGMAEGWQEGIVMDMDGLERQMATLEVIREDGEGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEV3</accession>
    <name>A0A2T6ZEV3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Allantoicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000328">
        <property type="protein sequence ID" value="PUU73999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEV3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEV3"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="272" mass="29935" checksum="4E72951911A7D73C" modified="2018-07-18" version="1">MMPASACLELQSSCSPAILTRLLTLLTSPLAVWKIFCSDQNFGTKAANALLPGSGKDTGNGWETNRSREPAHVDWVVVKLGAPGYIEEVIVGPSTFVETILKQLKYTLSIPPTNISPKQPISQILYKFLFPTPGPKDPATFDQFLNGVLDPEIRTEIAEWYNCHTSEELEEVYLGIMLTSISIASLLGMGQGESWRTWRLKPVQLERDPSIYDEVEDYDYGDKEDEAEDEEDGGEVGAAQREGRELLRAASPIPATVPPRAPHRPAVGIGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEZ8</accession>
    <name>A0A2T6ZEZ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1001774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEZ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEZ8"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="102" mass="11630" checksum="41E44EA1F526FED5" modified="2018-07-18" version="1">MAYSFSPPPITSKLLPRFIARQPFSTSLTPSLTSQPLVSNTNFTPLTIHRSWNPISYKHNQARGMKVRSAVKKLCECCKSVRRKGRVYIICSKNPKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFE1</accession>
    <name>A0A2T6ZFE1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_471663</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFE1"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028810">
        <property type="entry name" value="Alpha1_2_glucosyltferase_Alg10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="491"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU74205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="568" mass="65223" checksum="93AAAFCE3A7BCF28" modified="2018-07-18" version="1">MGHILVPWISALLIGTAIVSTYINYVVPEPYLDEVFHIPQAQAYCRNAFKTWDPKITTPAGLYLTTYPLSYVAKCTPSLLRSVNAWGVAVLIPAFVYNILGYIHPLKRPSEAVHEAINVALFPLLWFFSGLFYTDVYSTVWVLWGYLAWLRGCVGCSSIAAWWALWFRQTNVLWAGFFIVLEVGRRVRGLHDRLVDGERKVVTGKAVATSGKATGKRRRGKKRKGRVEIEEKRMEEGPEAGIEAEMEDGPWTIDIKSNGNVKGRGVKSNGYWKKLLEAVRKVEPWNPVFDNEVTAEDFFFRTPITHLISIIPNILALVSSTFPYLLVILSFAVFIVWNDLSIALGDKSAHQPTLHLPQIFYFTLFTTVTSLPLLLSPNLLYCFYDQNIGIYITTPPSSSRTRKSPKLTISYTKLLRTITLLTIILAIIWRNTYFHPYLLADNRHYVFYIFRRTLLAHPLIRYLAAPVYFASAWTVLYALKTSRSVNVLWVYAWAIAVIGTLVTAGLVEFRYFILGWVIWRVNVRVESAWRRWAETVGFVFVNLATVYVFTQWGFEWKHERGVVQRFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFR7</accession>
    <name>A0A2T6ZFR7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1093101</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000306">
        <property type="protein sequence ID" value="PUU74340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFR7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFR7"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18919" checksum="45875759A75E5136" modified="2018-07-18" version="1">MSTAWFDIAYTAPNGTVEQWGRINFRLYDDIVPRTAKNFRDLCTHEQGPEMGYRGSKFHRVIGNFMAQGGDFTRHNGTGGKSIYGEKFADENFIKKHEKPYLLSMANAGPNTNGSQFFITFVPTSHLDGKHVVFGEVADADSEAIVKKMESKSLDSSGRTSGTITIADSGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFU3</accession>
    <name>A0A2T6ZFU3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase L chain, ATP binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1000808</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000304">
        <property type="protein sequence ID" value="PUU74371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFU3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFU3"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="31"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="147"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="622"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU74371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="709" mass="77389" checksum="C8B6885E9E071153" modified="2018-07-18" version="1">MPRPQLARRALLSLTPSALRWQSSSIPKARPLTGILIANRGEIALRVNRTASEYGIRTTTVYTDPDAHAQHARVTPHSVNLGPPSAYLDVDKIIKAAKERGCDSIHPGYGFLSENSAFAKRVTEEGLIFIGPPSTAIETMGNKSQSKDIMLKAGVPCIPGYHGSNQDPEFLLQEASKIGFPVLVKAVKGGGGKGMRIAKTPAEFPDMLNSAKSEARSSFGDDVVLVEKYITTPRHIEVQVFADNHGNCVALGERDCSVQRRHQKILEESPAPDLDPVLRKDIWNKARAAALAVGYQGAGTVEFIFDNDTGEFFFMEMNTRLQVEHPVTEEVTGTDLVHWQLLVAAGLPLPLTQEQIERQMEGHAFEARIYAENPDMGFVPDSGELVYLRTPKTSSTVRIDAGFGEGDVISPHYDPMIAKLIVKGPDRRAALAKLRAALGEYEVVGLSTNIEFLKKLAAHPAFIAGEVETGFIDKHRSSLFAIEPTPPEAYAQAAMSVILNGNVQQTPADPFSVWGGNVGFVGSFQERIVEFVEKKGEAESRIPVSVKQTARDTYDLTVDGKISYPSVTAHISPLEKSKVIGFYPHTRLETTVVRKEDTLVVFQRGKQYKLDTPRPAWFEKALGVADVANSVLSPMPCKVLRVSVKEGDRVAKDAPLVVIESMKMETVIRSPHDGVIAKIVHGEGDVVKAGVALVLFEEDSESESTRAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFV3</accession>
    <name>A0A2T6ZFV3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1068289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000306">
        <property type="protein sequence ID" value="PUU74336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFV3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFV3"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="298" mass="33115" checksum="60B363837ECE4623" modified="2018-07-18" version="1">MSRFGVLVVGPAGCGKSTFCAALISHIANTKRSCLYVNLDPAATDFEYEPAVDIKDLITLEDAMEEMGLGPNGGLMACFEFVQATPRPGLPVASTDSSPPFRFLMENLDWLDHSLDDVGEDTLVIFDCPGQIELYTHVPILPNLAKHLTGHLQFSLAASYLLESTFVIDKSKFFAGTLSAMSAMIMLEIPHINIMSKMDLVKGQFSKRELKRFLDPDPGIILSDVHKETNPKFHKLNECVVGLIDDFSMVQFLQLESQNEDSVQGILSYIDDCVGWSEVQEPQIKDEPDMDYEEPIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG82</accession>
    <name>A0A2T6ZG82_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1000420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG82"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG82"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="511" mass="57259" checksum="58809AB38D8FE86F" modified="2018-07-18" version="1">MATQTFTREQVTKNNNADSLHVIIDSKVYDLTDFANAHPGGVHVLLQLAGQDATSEFYSMHRHEILTKYTKMVIGMIQGETPQVIEPMAGDLCPIPYTEPMWLSPEFKSPYYDKSHRRLQKEVRIFVDEYVRPEALRIEEVGERPSAEIIKRMADNGINAMRLGPGRHLEGYNLIGGIEPRKFNYFHELVLNQELVRTHGRACNDGFLGGMVIGLPPVLNFCRNTVLRDRVMCECFSGEKSICLAVSEAFAGSDVAAIRTTAVKSADGTHYIVNGTKKWITNGNWADYFTTAVKTEKGYSMLLIERGEGVETEQIKTSYSSAAGTAFITFDNVKVSVENLLGQEHQGFPVIMSNFNHERWVMACASIRASRMVVEECLKWANQRKVFGKRLADQPVIRGKLAKMISLVESGQSWLEVITYQMCNMTYQQQAKSLAGPIALLKNFITRAAHEIADESVQVFGGRGITKSGMGRVIENFHRTYKFDAVLGGSEEILGDLAIRQAFKNFPKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGA6</accession>
    <name>A0A2T6ZGA6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_435419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000294">
        <property type="protein sequence ID" value="PUU74523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGA6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="12301" checksum="70A196E149EE658E" modified="2018-07-18" version="1">MFSQIPHFISPTKKGGACLGWVGLGRLFGVFFWVCFFGSAFFGSSFLIFFFLALRKKEKAVWRNGWERIFLIFKTFYLFIYFHPTADIRIVLLEVKSGRKKLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGB8</accession>
    <name>A0A2T6ZGB8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_444958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000298">
        <property type="protein sequence ID" value="PUU74464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGB8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="19545" checksum="726FCF0BFDEE7F58" modified="2018-07-18" version="1">MVGLYENNHYSACGAHIISASLQYYSSTCTRAVEVHWCHNLGNYGEKVLLFSQRIAIGKKRKGSKEGGKAQSGGEKGERVGCRFFPHTTFQRSHCTLSKHRRLAATVAIKIQRLPCGSKLRACARLVYAVSRPIFFPFPLRRLIKEARLVTYIVSTSSAVAPYPSALLTILSPPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHX7</accession>
    <name>A0A2T6ZHX7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_996238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000251">
        <property type="protein sequence ID" value="PUU75095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHX7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHX7"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="163" mass="18376" checksum="C93894B0C7CB984D" modified="2018-07-18" version="1">MWPGTFFTILRILEILTLIPIWGILAFFVHEHPGIGNTAFSDILCLFIVAIFATVWAVATISLFYRRNLPMWAAVIDLCFFGVLIAGVVLLAPFVPDADCVGINWGFGYSNGGYGYTDGYWSKECSMYKAAYALGILNIIMFFFTAVLAAWIWRKHTTVAYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI47</accession>
    <name>A0A2T6ZI47_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000247">
        <property type="protein sequence ID" value="PUU75161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI47"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="104" mass="11065" checksum="407A2D3A0EB66881" modified="2018-07-18" version="1">MRIPGAEVAVHTSDGHTVPINPIEKCNIPIARELCCFIFGLGCSELGGFGGSYLICVLLALGRPQQNRVIFVKTATVLLLITPESLSTMLVLSGALILLLKFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIC6</accession>
    <name>A0A2T6ZIC6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_363063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000240">
        <property type="protein sequence ID" value="PUU75245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIC6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIC6"/>
    <dbReference type="OrthoDB" id="5418922at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="209" mass="23028" checksum="5FC1B66D6AA70E03" modified="2018-07-18" version="1">MSNQSTAIAGPAHSRSTTLVPIQLAVMEAARAAWELIGEEHIENFAVVGGAALLFYGSDNRTEDTDIAVTRESIDKFYQLARSDPRFAEDPYVGPWRYHTSFDFDVFIDFLDKSGAGGCLHELKGHCLIDGVPIATLADIAVSKGAAWLDRGLGKDLDGVDYVLRRMAGADLNFRELGEEGKRILDKMMVKLPPSEKGRRVLRMMAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIT2</accession>
    <name>A0A2T6ZIT2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Formylmethionine deformylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_354166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000234">
        <property type="protein sequence ID" value="PUU75405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIT2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIT2"/>
    <dbReference type="OrthoDB" id="5322539at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF3">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="705" mass="79223" checksum="379017BF7762386D" modified="2018-07-18" version="1">MAYRSREEAYEPDEERISAFSSPYTPAAEFFSDPPSPVQPTRKGTYTSVPVRHISEASTIHSQRQMGATMDMLERSKSREQQALWGTKIHWFMPTAMVCLLIAGISGSLGHHFFYASLQGKRADDQLMKVRYGTVLAYFTKASLVGSVVLAYRQRIWQTMRQKAITLRGIDQLFAVVEDPTCFASKEIYLKAKLATAMAMATWLIPIASILSPAALTAQLTLVESPNKTCTVPILNFTAENTADWLHPKGGRPGYSLSFINVTKDGTVWFDKPSFNAERLQVLATYSGKPINITTPCLKYNCTWAASFQAPWYNCSSKTQAEVALEIPKFINYTFDDLVPVGNKIYFSASDTPEYARPQPGYLDPILDKQGIFENEPAIWFGYVDKTNRFSNDSRVVLPPNSKPPTTYIYEMQRHVMRCELQKANYSISFSFVNNVQSANVSISDGTPAFTPPAGSSSFGPRDPGYKEFIAYHSLGLLVRQLAEGYVNLTNSNSTPITTTSLSKSRLLNQSDSFVVKNFHDEFQYFFQEIILTLLSEPFLEIGTTENVSCIRKRYENIFHYEMQGLWIGYAISSAVALLSIVTGFVSIYWNGITSDTLFSKILVTTRNRTLDKLVKQYEGVCLGGDPFPQELEKMPLRFGVIDERETDDDRTKHAAFGTVEETIPILAGDSYKRLAAHGSHYQSSRSWTGSPRAERYSESFQMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ83</accession>
    <name>A0A2T6ZJ83_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_332927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ83"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ83"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="762" mass="82704" checksum="A412A8C737E45CF6" modified="2018-07-18" version="1">MPGLTISDGGVTLGAAPPIVGGGKGSTMHGQQVMRITFDGSNVLEEVLKHEADLKITFGKSMRLLYGDHAVEILSTVESSRHELYRAKQGSLEGGLDFAGTFTHQLEVRELYADTADESFRALQESYRRINQEKEASTTVVVDSASMPPALSGRRAPYVKKSAATGRGKNARKPVTQPKSSHPNTPHMRAGKSPALSETDAAAHSAMINAKLEALRVPLIHLLAMGPDSEQNLASRTRVSEDVCLRILQKVGYRKSKLWELVDDVYKDLDIWEFPYPSQANREAAISSCRAAFNRLRLPREAPEWQKLLAFEDRGKVDPCPPAPQPTRPAKPVPPPSIKVTGDSTDPSQASPTGKKLSGGESMSRSNSQTAPAAKPATKAGQKDAISRIIGKKGTKKAAAPKAKAATVKAPKSANTKATKAAAAREANAASANSKIKSAERVEDSDEDIEMEDVKLSPAKPVEKKTTLATRPAPSPMSKAPSIASAPASDLEVEEARLKPKKALPNKVQKSPIKKVRKIAPPKSSNTAAAKANGYKVAPTSNASANSLSSKEQIARRSSSNSPPKPSPLGSSPPINASDMDGITAASSPSFLTPIARTATPGRSPLDSITLAVKPKPHYIPSNSPPLKRKATSATDRDREDTYSRPNGRMIDRERERDRDRERDRERDRDHDRERERERPSTSTSTSSSTSSSKRRNIALDISTIQLARKFKEDYARYERLHREVQAITDAFKKKEKLDTVLKMHSDLEKMKATIMHAASVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJN7</accession>
    <name>A0A2T6ZJN7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000218">
        <property type="protein sequence ID" value="PUU75701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJN7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="16898" checksum="F56227FD7BDD84B4" modified="2018-07-18" version="1">MGVLAEDSLHRGLLYRTMRCVAGYIVPAVTCEGFCAVLVHLKRCFFVAILLTLLLDLLYRYKRRPLRPMVEKENRGREFPGRAGIFRRFFLSLFLEPSRFRDIPVPMPTKRTPSPGRPPTALGQSIVHSKAKMSFSVLGFSLAGGRGLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK98</accession>
    <name>A0A2T6ZK98_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1053240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK98"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK98"/>
    <dbReference type="OrthoDB" id="436519at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="343" mass="39385" checksum="200E270040DDB3BB" modified="2018-07-18" version="1">MSALLSFIGWSFLPSLATSSLLSFWYRLITRAGDPRPQPGTPTYAKAYRRVNFLVITLYLLYTIYESYNTILLQPNFYKLLSAGMRANDRELKGKFRRLTVMYHPDKVGTQGEAYFVMLKTAYDTLLDPVKRVAYDRFGPDILEWRHCSSTYDYLIRGVTMMVPYYLGSALVLVILSVLGKMEFGRYWRFYTFFSMMVLEALVVTRPFHHFTRIPILNTLLPFEQLALARKILFTTFIAISQLAPLFQQGRVITGPLTAEALDPHLDRMATLLHRTDAEASTMLTQELLPFDADPGMQQMLKKKLEEWMIESTIRGTPEVRDAVGKVIQRRRTDAPASAKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKB4</accession>
    <name>A0A2T6ZKB4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1130588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKB4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKB4"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36307" checksum="C09FDAF2E5870871" modified="2018-07-18" version="1">MFPPGRGSDPLTAGDIYRISLFGTNLMIAAKGEKLCLQEYQKDDLNQMWICEMNLDRRISMRNRHTKCFLGWGKDHTVGCSSSNSGASAWLTSTRLSLGGYSLDLSQEGNNELTPLQCSSNNGPDLNAREVYTQFGLHRVGGSVFRRFEWVIPNRLGRSSAPYYDGEDADESINETSIEFLNKYGIKNIISLNSIELSPRQRGRLRASKISYSHIQAFECTAVTQEQFDQIWNAYDKSGATTIVYCGYGDGRTGIAISAIQLFEGRALDDNDYRGNGVQCPSQIAALNELRGRINSAEKHSGPVGTLDTQLPLYTALEDTAPEKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLI3</accession>
    <name>A0A2T6ZLI3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1088419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLI3"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="61"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU76349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="227" mass="23951" checksum="FCDC42AAD06588E2" modified="2018-07-18" version="1">MSNPRIEDVTEEETKQAEVEDAADSDEDSEAGDLIGGGAGGVGDAGEASGIPAGSSVAVHSRNEKKARKQIAKLGLKHVPGITRVTLRRPKNILFVINQPDVYKSPSSNTWIIFGEAKIEDLNSQAQTHAAQQLQQHESAASIEAELAAVAAGGGVGGAGDKGKDAQALKKKEEEEDEDGEEVDEEGLENKDIELVMAQATVSRKRAVKALKDNDNDIVNSIMALSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLS6</accession>
    <name>A0A2T6ZLS6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1102367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLS6"/>
    <dbReference type="OrthoDB" id="2890403at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015475780" evidence="2">
        <location>
            <begin position="18"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="580" mass="60408" checksum="D3707234663D6461" modified="2018-07-18" version="1">MFISLLSWLLFLPAVLCQLSSGGLQKFPNALALGNTFDPIIAAYWTGLPHHRRTPFSVSPDGKSAYLAYLASTYDRVFVQQVSPDTFAAVGNPIEISGAREAGGLVAQNDGFAVMVNLDNSQTDHPVTTIIRYKGGAKAWTTPVNGPGVHPSEGLSTSPDMNGDLVWSEAAGLYAAYFVVTAYTGSASGHFGDSIQYVTDAGDIKTISGASSTFGCSHNTGIALEAADAPPFASVCAEDHGSIWLNTNTQYMSGVKIANENTTNGVSGEPMGGMSGSYSSLASFPGSSAYIFAWQSRGAVSLTRDDWMGDGYTQCSPRWLNHNVAISMMKDKSTLQGAQAISKVGAASGDDQVIWITKSTTTDQQNVHVATLDSSNAIVTWEQLSNPNCQPVPLGCTGTFSGTFFQQVDSTGKKVGDAISAQDVFVAGDMQRIAGKGLCWPYVSMNWDLSAPKDKGTPVSSMSFACIGGTGSTSPAPSSQPAVTPSETLGTVTPIPEPSNTTTSSPAMSTLGPESVPTTTSSLPSTMVTKTKKGKTSRSSGATPTQGGSYNFISCDAQSPCPEGNTCYAYGGGGFCIPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLY3</accession>
    <name>A0A2T6ZLY3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1088127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000186">
        <property type="protein sequence ID" value="PUU76502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLY3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754493" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8911" checksum="6B4FE75840F5C504" modified="2018-07-18" version="1">MPIPTHPFSWFFFHLVFLNGVIFNSVGPPPLVRSAIYMTSASPGFHSPPPPCAFYPRLSLLHPQPIVLRVSVILRAQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMA7</accession>
    <name>A0A2T6ZMA7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1066463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMA7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMA7"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="259" mass="28323" checksum="BA6CD8A4D00BC6A7" modified="2018-07-18" version="1">MFRNNYDNDSVTFSPQGRIFQVEYALEAIKQGSVAVGLVSKTHAVLVALKRNAEELGSYQKKIIGIDTHLGVALAGLAPDARVLSNFMRQQSMSSRLLYSRPVPISRVVNAIADKAQVNTQHYGRRPYGVGLLVAGVDETGPHLWEFQPSGMVLEYKGAAIGARSQSARTYLERAFEEFVDSSREELVLHGLKALRDSLAQDKELTVANTTVSVVGIGENFKLYDGDEVGEWLEKLGNVQSSRGGRTGEEAAESMDTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN11</accession>
    <name>A0A2T6ZN11_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1051199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN11"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN11"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008909">
        <property type="entry name" value="PRK12273.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="97"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="494"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="549" mass="59188" checksum="9C0A09D899BEC7CC" modified="2018-07-18" version="1">MMNVSLRTIARGLRLHVRDSGARVGGGRGPLPVSVTGQRWGTTVIRSARGEASRLPNVCDNNAASSSSITKLQFFRQFSTSSYTMADNFRIERDAFGEIKVEADKYWGAQTERSLTNFKINQPFDRMPPAIIKAFGILKRAAATVNMNHGLPGDIGKAIQQAADEVISLKLLPHFPLVVWQTGSGTQSNMNANEVISNRAIEILGGEMGSKKPVHPNDHVNMSASSNDTFPTVMHIAAVMEIEEKLLPSLKALLAVFQEKVKSFEKIIKIGRTHLQDATPLTLGQEFSGYATQLAYGVERIEATLPRLKLLAQGGTAVGTGLNTKKGFDVAVAAEVSKLTGIEFKTAPNKFEALAAHDAIVEASGALNTLACSLMKIANDIRYLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAMTMVCAQVMGNNTAITVAGSQGQFELNVFKPVLIKNLLHSITLLADGMTSFKDNCVVGIQANEDRIEKLLHESLMLVTCLNSKIGYDMASKVAKNAHKKGTTLKQSALELGALTSDEFDRLVRPELMIAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNB0</accession>
    <name>A0A2T6ZNB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_200924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNB0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015692283" evidence="3">
        <location>
            <begin position="20"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="38817" checksum="AB02D1EC4D2D326F" modified="2018-07-18" version="1">MFRLLDIIHFLLLFSNIVGEKQKEGKKRERPSPNMLSILLFSALLTTCPVLLTLSAPVHQIACFLELEPLPTTAPPASPFLSLPNASPPPNPSLNKRSLDKALEYFHLPKDQLEASLAEAAAAYEPPPSPLAQDPNDPNYTPPNSKDLDDDDDKEDKEDEDLISQASSIIIYNGRPIEIDGRPTLSRRDLLSDKKSHIGHRRKKSGPGLGLTLESTTPAFTVSKKKSNERERERHAPVKVQEEKKEKKKEKKKEKKKEKKEKEKKEKKKAKKVPGGKAMGLLEKRGRITYGWGEWEPEMQYLEALSGPAIISFAREDDLDSGAWAGEAPNQLAKDRFWRDAISRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNF8</accession>
    <name>A0A2T6ZNF8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1087243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNF8"/>
    <dbReference type="OrthoDB" id="5462315at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="23022" checksum="183470038BCAD6A7" modified="2018-07-18" version="1">MDSSTGFLDFIFSDSPKNFKAAYVSLDSEPYQIFDLLLKEGRFTNFFSRIEIYGNNLATLLSQLPRLEQDDYNASLLREMIRAFALSLLAERCDDRKSRSAVARIVLSVVKLSDPRGTLGQFGVRLGALPGILRILIAEGHIKNLAVTHKGCFEDLVSEPQAKEKWVELIVDLCKECRKHGMRPRATDAIEFIRRLGWKKNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPR7</accession>
    <name>A0A2T6ZPR7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000152">
        <property type="protein sequence ID" value="PUU77467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPR7"/>
    <dbReference type="OrthoDB" id="5418636at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="811" mass="91127" checksum="7381ACA30CB83451" modified="2018-07-18" version="1">MSFYETQPPCAQDASFYSAFTMNPPAALPAHHWPSLSNWVAHQKQVWLKEQKRQLAYQLCRIIDVEDLRAAALRKMHIEEEEWGGQQQQQQQSNEFDGFSYNSAQISEENFSLDARHDQPMHTSFHNMPPHPFVAYTQNDENFASRPLCGKQAYRDDTFANERVQVDVEEECYSNGQKLQDCVLDHTRLMSTSGTAKAQAVERMNGLAAYVAELKAQMAEKMNSGDFTMDASTARGYEQYTRTPEFFRARRNERSQNRLSSAEHSQVEILEGSREQTLTHSTSSGDSGTPDLYVSSQTQSVDSVNSFECSPDEPIFRSPDGPALKIFAPQPAPPRPAILQMASDETVEESYLCYGYGVDGAEALHWQLPDWLWYHKSQQAGVEAGISYDFNYPPCGYAATPEFVELHYAGELDHPASAEHRYEMEPVEEEEISEDGSSPRLTPSEYRRGCTPRYFIDSQSQLGYNVSVPSPHINGSFPSVPKQSEGVIGDHHEQGQAAEMYTDGECFPQNGWGGMRDFLPTGKQSEGEPDGQWGFGAHEMSTLPGPMADPHEILRARIHGIPPVYKRGPILPPTDILEPSIFEPFVYEPATCLNIIGKEAFMTNKASKPADLSPTVCGSPPRATPQRQEPRRTENFSSSLTPPNRFRHPVDSDPLTPESPVFRKSTFPDSGQFVVHNTNNEHLFTPSPRKPGSSPPRFALHTRKSNRKKNRGEVKPQSIEAIEARRAAVSAYLEIQPSEWPIIPEWPTPGPETPLQSSPFPYSVDTPSPSVLVHKRHLKNRRAKLLPAKQPAMPAQEEPRPVYANAQHYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQE5</accession>
    <name>A0A2T6ZQE5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_985874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQE5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQE5"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="857"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1265" mass="139642" checksum="7542D6B4BE812AE4" modified="2018-07-18" version="1">MTASKPKPPIPPPPPGSEIVQAPLRPAYTGSDPFLERNSNGGGNYHVRASLDIPRESFGTTATVGRGGMSKPTSGNDYLSAHTLPRGFTQSSRQRPLSVHSTFQSTPTHSPPGFRFDSPKTSPSPLNLDARGPSPERRSDSTRTMPAASPRSRSFRVSSRSNSRSSSPSPNTQYRAPPPPPVSSRPVRHGQPPPPPPAAPPLGGVSGDRRASIPNNGAFRRPPPSPALQGPQDYNEPEKRIQPEHTAPPIPARPTKPRIPSKPSIPAKTDRTGPNSGLAPAASEEEHVSPFSTPPSSTNNSPSRSDNESGKQPRVLSKQVTGMLNYAPPPLHYSTVERARERNGAGVDTGILPGKAPIPPPPRISREEIRPRMKLEDSLLGQRTSLDDTGLRPDLPPRPPGGVVGGIRARVPSLRGRSYSPPRVSSELGPAPEPPTPPFLPPPRRGFSFIQAKTSGGQDTAASSSRIFSNTSIATNSAIHSNGAEDSYGGYGPDDSDEALSDENQSALSEYPDSSQANRRHPYFKSGVRDINCRTYVKYFAVCGKYVCTTNNATNVWNIDTGQCIMSINHGESTKVTAIAFKPSVNVEDEGKQLWIGTSHGELMEVDIPSQKITNTRASAHMKKEVVQIHRSGYELWTLDDGGKLQVWAPDVNGVPNLKNSPTTFRIPNKHTYSLVVDGMLWIGAGKNVHVYQPSSDSRVQFNVISRPLTPNKPTAEITCGAVVNSEPDKVYFGHSDGKVSVYSRSKFTCLDVVNVSLYKINSMSGVGDYLWAGFKTGMIYVYDVRTKPWTVLKDWQSSHGPVVQVVADRTSIWKVGRLQVLSLGVDNVVRIWDGMLEDDWLEKEMQQHDVEFCSFREIKALICTWNAGASKPQDLLTREDDKVFLEGVLGSVDSPDIIVFGFQELVDLENKKITAKSLLKGSKSKKKKAADQQEHMSHQYRLWQQQLTKSIETHMPRDQPYVPLHVANMVGLFTCIFVKTSERHSIRNVCASTVKRGLGGLHGNKGALVVRFLLDDSSLCFINCHLAAGQSHTISRNNDIAAILESTALPAEPSAEARTDMFVGGGDGTMILDHEICILNGDLNYRIDMHRDSVISRERQGDLPALLERDQLLMERRRNPGFRLRAFQESQITFSPTYKYDVGTNTYDTSDKKRSPAWCDRVLYRGLGRIKQTAYRRWEVRASDHRPVSASFLIRLKTVDHELRGHVWEKCKRRYTDVREREVWEAKMDFLVNVCGYGLEEARRSLGKKEEIVEAVRSLQKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQI9</accession>
    <name>A0A2T6ZQI9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1085576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQI9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQI9"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015662808" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="192"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="714" mass="79831" checksum="7EC6632FBD0B6706" modified="2018-07-18" version="1">MITTIMQLLVLSFLALPLLGVEAYNALPPVPWQYSAGTFKFSTRQPPAIYLQTSAAEVRDTDGLTLIPPSAREFAETFAGDLKDVFHVDIRVQCVPFESEGADHGPGIYLGIDELGKYTYESGVETSEGYTIDVAEDSLRILGGGARGIWWGTRTLLQELMLAREATGVHQGDGTEEIIELKAGRAVDSPAYPTRGFLLDAGRKWYSADFLKDLCTYASFFKFSEFHYHASDNYPLNRGHNSTWQNIYSQFSLLPDNPVLYPLVPRRNESHNRAEFESMQTHCASRGITIIPEIEAPGHALAITKWKPELALGLKDLLNLTHPDTIPTVQAIWSEFLPWFQTKEVHIGADEYDSSLADVYIHFVNTMSEFISATSGKRVRIWGTYEPSNTSVISKAVITQHWQYGQSDPVQLEKDGYEIINSEDWWAYTGLKNDHTPILPAPYPQYFNNTRVLNFGGTNGWQWEPSLYNPFNTTAEWQVPIESKGNKGAIMATWNDNGPDATTQLEAYYCIRDGFPVVGARSWSGRRGPQINVGTLGTSKSILTNNAPSQNLDRRLGRGYNPGDLLFNWPTDATDDHLAAKSKGMNYTMQITYTSWFTLSSTQDAVSLTLTSNSTLVFTADGFEYPLRSVAESAFDPGLPGRIWANDTTSTHTPTDKIGGSRVWQNDTFLGRFEVFVFGGRNRLFSWSQMAFVAPVEQVRGGVREVKIWEGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQJ1</accession>
    <name>A0A2T6ZQJ1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_985767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQJ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQJ1"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="385" mass="42841" checksum="57523924913D6A6E" modified="2018-07-18" version="1">MAWTTLQLEILQTTSRVSSVFSLLGASFIIITFCASTSFHKPINRLAFFASFGNILTNVATITSRKGIEHGDQSALCKIQAVLIQWFMPADALFCLAMALNVYLTVFKKYTTKRLRDLELIYILVCYGIPAIPAIVFLFIKNHEGVYIYGSATLWCWISNEWQFLRIAAFYGPVWVILGITVIIYILAGRVIFRLRGSLRNFAGKSAPRPPPAKDTWSTGSHTLSRPMSPDLTPGPAAAIGPLPSYTVIIESGPPKPSTANNRAPRNSAVEANTAAWAYCRCAMLFFLALLITWLPSSVNRIYNLIYPDATNFGLNFAAALVLPCQGFWNGLIYIVTTLPACKAFCRNVWKRLRRPLDKLAKWRRSRRNLSSKASASSLNSLQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQU2</accession>
    <name>A0A2T6ZQU2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1065537</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQU2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQU2"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF9">
        <property type="entry name" value="GLUCOAMYLASE, INTRACELLULAR SPORULATION-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="10">
        <location>
            <begin position="169"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="319" mass="34554" checksum="23E6621E3645F2FF" modified="2018-07-18" version="1">MCLLRLWLGERRGAVVIGIAPSLNLSSLGRLLKGVPHRSLPQPSTQLSGQKKYHSINYIRVGIAQAATTAITPGSTTTTAATILIATAASAITATATPATTTTATGIAAAAAKSLVLSGECANSPRITILSATTKSGLQSKAALKPSKTQHCRILVAGASQLLLAPSIRPQRDEPTLRALTLINFIRAVNQTHPELVTLQWIGKLYDPDLAAKSIIKSDLEYVSHHWNAFGFDLWEEIEDLHFFTVLVQHKALVQGRDPALSLGDYRAVSWYDNQQAALNRFIKTEFWDGRNGHLKAYQHTPYRSGLDCSIMLGSIHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR17</accession>
    <name>A0A2T6ZR17_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1085327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR17"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="59" mass="6723" checksum="F5EF67B24AF83E31" modified="2018-07-18" version="1">MMARAKERAAIENDRGWGGQRAAKKSLNFFKHVWLERSRRLGGNRSEDDLATAEILGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRI2</accession>
    <name>A0A2T6ZRI2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L38e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1049138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRI2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRI2"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="8935" checksum="F53EC6FEB62DB368" modified="2018-07-18" version="1">MPKQVHEIKKFLELCNRPDAKAARIKKPTKGSNTIKLKVRCHRHLYTLILHDAEKAEKLKQSLPPLLPITEVPSTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS67</accession>
    <name>A0A2T6ZS67_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000122">
        <property type="protein sequence ID" value="PUU78340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS67"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS67"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="13081" checksum="CAFB20D54167D83A" modified="2018-07-18" version="1">MATGSSGGAATIMRKKSVTWALPTLSRPRSPPPVVILPTHPPPCSATPQIEEELTLEFQIIAYGPAGYCCPIEDYQDIGARTLNANYWRESFFYQDIPEGTSGRAGDCPGIEGVPWYSGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS79</accession>
    <name>A0A2T6ZS79_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000122">
        <property type="protein sequence ID" value="PUU78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS79"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="20269" checksum="4CA5EEE62B34E80F" modified="2018-07-18" version="1">MAPNWVCQHSESAKIFQFLTDRDVHSAQVVVCAFARTESGLRGGGGIGEVAGDGFKEVSCIKGVCLVEALRDVRDAEFVPRVSDRSAWDCSGEGTTGPVCAGGEVLPGIIEDARHVTVLENYAVEETVKMKAPICDGEVAPTWRPSNKQEEQSHKEYPSLCPLKDNLITECEIRNPAGVWPGSFMKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSV7</accession>
    <name>A0A2T6ZSV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1101313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSV7"/>
    <dbReference type="OrthoDB" id="5378670at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015680784" evidence="1">
        <location>
            <begin position="36"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="407" mass="45149" checksum="1A957B1AE63AC83E" modified="2018-07-18" version="1">MMSGIYRSPGSSKCLQILDLLSVLLVSESPGGTAAISIYRAASEHIEVWYSKGRPSTKAEKASVVNFIRSAVEATLVSRPETEHLLRIALDMCKYKVFARIYQARQLLLQLCLDGTYGIIPSASYADRDLRDAAKIELRGVLGEDELPPERSLERCLTLWFQDIILAVRPGVPFDIAANVEFYFQTVVRCYALLKLPRIDTMIESDLLEKLRKVSEYYTAVSFVHWEVQKLSPGGKAHLISSIREIPPSAPTTCFTPLDPLICLSNWAYYRGLTPPFPFHPSLPALPNQSHITECTHPEATLITKIISTHKSSPAALREIGASKASCWICQEFLAAARGLYPNISIRLLKERLRTAGSWKFPAGTPVELVRALTRRIEKAMGEVLEECDGANGVKGTVKRKFGGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSY2</accession>
    <name>A0A2T6ZSY2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSY2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="53" mass="6016" checksum="69BFCE1CF2D2DE73" modified="2018-07-18" version="1" fragment="single">MFGIFSLLVAALVFLYCGFGVFFGFGDLICFLFFIFNFSIVGLKRRVGYQQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTX1</accession>
    <name>A0A2T6ZTX1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTX1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="311" mass="34999" checksum="049C7A516A2F4D07" modified="2018-07-18" version="1">MSEGSCSYRSASPSLSDFGSPPQTRLEPAEVRCYLEEGLEGVGRYKYLKPNSIITTINREIREFKLHAPAPQYAVFSPVTEKEFTEIDKIRNRHHMAVKFLFLTNERTLVVKFVVDIAHEIAHRGFVRLFLFKISSMDLTWDMADLGRGRFSGLTGQKEADTALKPMSRPYITDWPTVVFECGVPESLERLKVDAKWWFENSEGAVGTVVIVTVSVEKRSLCAEMWELADVANPDATQTDPNPFITRATRTGGCKIVGETVTGDPLKISFKKTMLRDPDETLGEGDIVFDTKEIKRLARAVWAGTKTRPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU36</accession>
    <name>A0A2T6ZU36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU36"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="12347" checksum="FD83F262F5344CC7" modified="2018-07-18" version="1">MNYQGHSSLDYYSPDEVMLNQKPGWEQAMSITSRAQQTISNIHEESASSTQLENSSKAVSTLTRTQIPFEKSENQAYTYKITGTINNQLVQVHDRSDEQYSRPEVEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUH3</accession>
    <name>A0A2T6ZUH3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_980498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUH3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUH3"/>
    <dbReference type="OrthoDB" id="4204700at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="407" mass="44587" checksum="ACBE077891D0DA5E" modified="2018-07-18" version="1">MPLDIADNDIPASEPDPFGGDSDAYDSSSTGNYPSPPGLAPFSGLLGYSEANRDLFIRHSLMNTTALLGLKLTPTEREGLAYYNSRFYSYESYGDTLGISAGVLIAFLLRNRKPGIISTAMVRVFTKPGAQRDNAAKWLSRGLKLSVWGCVGRMYGLTSAGFQAIQKNRVEKRADPNLRRVVAATDKKKEALVHEIQVSRPELRRMKGLENPKAQDDEQSLGGVEVSDGTESRLDASEKERFPYGRPSEQVAELEARKRGGGPPGDDPFGVDDASPTGAERATGQGQGGWTNTHSNTSESAWERIRKGQSPTTRPPTDRSKDGVNTKGPNESKVGGWPNRALVNGYDQGDTREPRTDSFAFSKSEEERQLAKQEAQKEFDAKVEKERSGEMGDGYVEGDSRSRRWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUP4</accession>
    <name>A0A2T6ZUP4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_911862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUP4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUP4"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="17023" checksum="1E805A75750AF5A5" modified="2018-07-18" version="1" fragment="single">ELEEEVGDLASSSVGYKQLRHRFLSTFKRDKLGIITDRDQDYIGGGNVSAHGGDAVVDSQLYKGIGSRDDFATFKRLYGFPPQVVQVLTHPETINLLNCHAAVRASNFKNGSDKFYKLFKEFVEVFEDSDYNQGYLSDETKSVTKAYQAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV36</accession>
    <name>A0A2T6ZV36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV36"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV36"/>
    <dbReference type="OrthoDB" id="5504215at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="932" mass="99625" checksum="3CC0649CD2CE68D3" modified="2018-07-18" version="1">MPPPFEGQGLIAVRRTVYAAPGGNYASMEFSHAEGCCNTAPHHDAVVRDLVARIGLYDFSLVEASANAVLLTRGCLPECRFNRESTMGLYVHTADDGSQYVPPSSTPNPSQLTSSGDALDPVASDALVPSSSWPVLTAPTPPSPSPSPVRVVPALPTQSSSSSTYYGSTPSSSLLHALSSGERRLYGPNFRLDASSDVTYRPTDVSSPPHDGVTGFGGSGFDQSSPALPIDQRVSAPVPVSRRGVRFVGANETHPHTPSPAVSSLGVVARDDTPLVRCSQSVVDAPMSLGEGKNSNATGLGDSMHAVPESSLPSSIARLPPTASDTTTNMWEALDDIREGRCSPMSQSSIETDSSCDDIPTAQFRFLGADRYSNLDGVADDVRALGNGHNDLLEVVSRMAKHITTLERLTQRLVRRVNALEDNEDHAKFSPCPVATNTPAVVVPVTVPNTDGVAATAARPNPPPPPPVPNASRPTNSGPAACVPSSWVEVARRGAKQPARREQQQQPQQRQRPKQVQPSVSPNPITARDRHVTMRFATRKSIALPHGCSAESIRARLNAFFANGTKIRGSHPYVREARLRADIGSIYMTLAEHSSEEIGGMLERAHAILMREFSLPDFSFARDTKKLDILVASVPLADTGHGSVWRLEDWTNDRVYDGLRTDLERSNPGLITAGRPNIIGSLHAMRASNSTNCAIKFTVEKSSESDAVLRSARVCLRGGNRTVRLWTRFAPAKVSNNCLTLGHISTLCALPPRCRFCRGNHASRSHVCTTRNCDSVTGDACQHTVRLCLLCESSGHYTGFPQCPSLKMTPDGSPPPLGGSPIVEASDSISGAADRSRNRENRKRQRRRRPTPVGERQINDSVEAKDAAAGDNASNKGKSRAWEITDEEADGFADGSWDPPGVDITTAGAAPRSIIERPASAPIEGPTSGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVT1</accession>
    <name>A0A2T6ZVT1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_930805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVT1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVT1"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="26153" checksum="1C64AD36523921E4" modified="2018-07-18" version="1" fragment="single">CEAILITDTIVGEEDKMKEVAEKAFREELDNENLEVMHVRDDVFVGNRRGLRLAEMKAMLDAHESKVTFLQGHVKELEEHVKELEDNDKALTARVSSLSLAVYEYKQIRRRFISSFKVTKLPEAVEQSDHDIVREGNLVAHGGDAVIDALLYEGIGGREDIYAFQQLYGLHPADVVLRLTSPAHYETLNLLNLHAGVRADTRKTGSEEFYQRFAAFILAFQLSSRKTDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW95</accession>
    <name>A0A2T6ZW95_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW95"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW95"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="267" mass="28937" checksum="D756AB6C1FFAAFE6" modified="2018-07-18" version="1">MALLAIFFSATGITLGLWGYSTYLTYLANTTHSFPEPVAKELRKALYYSLPNSSSPPDAVKHFRLALEQCQDLGMDPLSDEVTGIKIELAGVLLHHGIVEKGVEVLEGVLDEVVAAAEAEKVDEGVRRKLLLRGVKIAAKVGEVYVGKGRYAEAEEALGWAVETAVREARKTPPSPPPPPSPPEEGGGERLPIEKTPGQDPQPHHQDWLSNSEMSSLLEALASVYGSTNRFLLATPLYLHALEYMPPNNCHSVVLSSSLPSTPSVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWN2</accession>
    <name>A0A2T6ZWN2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1080596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWN2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="7915" checksum="2513A5C4EA4103D3" modified="2018-07-18" version="1">MKVLNLSLHTPALVSLVSYAANTREFYVCPKVLSRNQKFSHLCFSFNTFTPQRTIPVPELITSSSALSLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWR4</accession>
    <name>A0A2T6ZWR4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_977039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWR4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWR4"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="58"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="310" mass="34644" checksum="2A9AACDEBC062EC6" modified="2018-07-18" version="1">MSDFDNSTSEGTATQIVNGSHPTIQNTKADFSGLANSASSQNSDVTDSDQLTHYHSFFYDLFTWKFPRATGFFFFSAISLIFAFRFVNVLRYVFKATYLLFFGVAFLEIAAKPFGARGFISSIRPKPYWTIPRDSLDNLFGELHDLLNFFALEFQRVLFAENIFATVVAFFASFIGYFLIKYIPFWALLLLTTVTAFTAPLTYLQNQEAIDEQLQWANEYANAQLVNGRQIAEKYIDDASVRARATAVELTQKVQVYAGKKSPTAEKSQASPHSANNGPSHQFPDAPKSDFPAVDDESDTKVAAPEPVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXC6</accession>
    <name>A0A2T6ZXC6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXC6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015694541" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10702" checksum="3C45C17C1746CB24" modified="2018-07-18" version="1">MFGISAMALLFVIGFLSVCIDSPPQRYSRMVPLLFSSVVTNVFSPLSDSRRPIYSLKCQLLLNSLLKMHNTQCCDRARERKKPCYSSTTHFTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXV9</accession>
    <name>A0A2T6ZXV9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1100334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXV9"/>
    <dbReference type="OrthoDB" id="5419617at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="50"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="18639" checksum="381D5C94A6CEF437" modified="2018-07-18" version="1">MCNSKFLKSLQLPLGSLARVQPLPPSSSAPLRPPALLTPPLKIQRLRREEPNEILIYTDASHRDGTSSAGIYSCGVESISRSLRLQPGLTSVEAEREALLLGIAIGSRIARRAEREVVTVCGDCIPALQDVAKLIYEGKLKGVSAKVKVKVEWVKAHSGVKGNVSAHKLARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYD4</accession>
    <name>A0A2T6ZYD4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1123466</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000063">
        <property type="protein sequence ID" value="PUU80491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYD4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYD4"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="34"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="376"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="603"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU80491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="790" mass="87225" checksum="38D490C6E7C80FE0" modified="2018-07-18" version="1">MASSRYSTKSDRGGVGGDEGYVATNELVDPETLYTKQNQIGGGSFGKVYKGVDKRSGQSVAIKVIDVENAEDEVDDIIQEINILSELHSPYVTKYYGSYLKGSDLWIIMEYCSGGSCGDLMKPGVIAEDYITIIIRELLMGLEYLHSDNKLHRDIKAANVLLGSNGQVKLADFGVSGQLTATMTKKNTFVGTPFWMAPEVIKQSGYDQKADIWSLGITAMELALGEPPYSDIHPMKVLFLIPKNPPPVLEGNFSDKFKEFVSLCLQRDPRDRPTAKDLLRHPFVRRAKKTTYLTELIERHERWVIENGNKNKNMDDDASLKMDSTMDSRSTDDSDAESDLWDFGTVRAVGGSRNPGLSSLSAAAANMRYVAQSIDQDYGEQARSKVERLPVSPPRTGPSVPSRLPGNPSPTRDMPPVAPPHGPGGARDSGYASSGTVRGLSRPASYQSLPPTTANQDSPPPYKFQQQNSQLQPISPPRRPNFTPAQTPRQREMSVDETDRSIQAELAQDMSWMKLARNQGPVNGIVSVPASIPASKGIASDGRIEVELNSGVPTPANAYGDPRQGFPPLHPPLHLPQLARQSSSDIAQEQLRRQLQHQKMLPHQMPAIGPPPGLHHPRLQQPPQPPSHHHINNGINHHQLPQLPPPQQHQQHQQHGPRQMTPNHKEATPEPPELTALDGVILPALEAALQRRTYHLQSAIRKAQQSSLATARQTVQEKQQAHDRLKRLVIKAAGIFREIEEWDSTAPVGMGGDVNGFLEGFLEEVLVRVEAEEDDGNNSNVAREDENRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYJ8</accession>
    <name>A0A2T6ZYJ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine alpha-hairpin motif superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1079320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000063">
        <property type="protein sequence ID" value="PUU80495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYJ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYJ8"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12362" checksum="9804EE53593B63FB" modified="2018-07-18" version="1">MRTEPSEPEQTMPAAPLTAPAPSNNHRDIEDPLHPETKAKFKAKPSSQYFDPCQEAANRSIRCLNRNAGDREMCLDYFQAYRDCKKRWIEDMKEEKRRKNRMSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYK2</accession>
    <name>A0A2T6ZYK2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1079201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYK2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYK2"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="139"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU80561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="295" mass="33427" checksum="A1EAFF76ACFCB765" modified="2018-07-18" version="1">MSSIPEKEHPELTPFLANLFSVIYTSSYVGILYLSHLTRPQPGLARDTPFVIRARIRAVTVVTIIALINSALVTYFYSPHKTYLDVAAFLGIYVKLPLTLDILRCLLLTTTLFLGPLVRRLWLEDGLGELRGDVGIMFTTWIGWRNYVAGPFTEEVVFRACMVPLHLLAGRSPGTIVFISPLFFGIAHIHHAYEFYINTDNPNRIVVMIIRSLFQFTYTTLFGWFATFVFLRTGSVWACIVTHSFCNFMGVPDFGPVDGPRWRSVVCYTLLVTGALGFYKLLWPLTESQHALVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYS4</accession>
    <name>A0A2T6ZYS4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1078879</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYS4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYS4"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="235"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU80624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="455" mass="50276" checksum="13AAC4EE09856E9C" modified="2018-07-18" version="1">MASLEDLEDLERERDQDKKAAKDKGVSDDDAKMAVDGDKDDDEIDPEVLNGSTTDIIYRKRLLENDLRVMRQEFQRLTHEKSSTKEKIKDNLDKIENNRQLPYLVGNVVELLDMDPTAEAAEDGANVDLDATRAGKSAVIKTSTRQTIFLPLIGLVDPEKLSPGDLIGVNKDSYLVLDTLPAEYDSRVKAMEVDEKPTETYGDIGGLDKQIGELVEAVVMPMEEAERFKRIGIKPPKGALMYGPPGTGKTLLARACAAQSKATFLKIAGPQLVQMFIGDGAKLVRDAFALAKEKAPTIIFIDELDAVGTKRFDSEKSGDREVQRTMLELLNQLDGFSSDDRVKVLAATNRVDVLDPALLRSGRLDRKIEFPLPNEEARAGILKIHSRKMTVEEGVNWTELARSTDEFGGAQLKAVCVEAGMIALRSGRTKVSHEHYVDAIAEVQAKKKDTVNFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYW2</accession>
    <name>A0A2T6ZYW2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COP9 signalosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_974005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYW2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYW2"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="53"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="218" mass="24079" checksum="727AE82941047A64" modified="2018-07-18" version="1">MSPEKDTQKLSLAYLSTLASSSEIPSTIVEILADLETEAALTPFSPESAILLSNFYSIYFFALFLCDDLNEARFLSKRIPVPALQSDPLLISTYTLLRFLYTRNYAEVYTVIDSAPWSEHVSPLVVRFKGSYRQKTVVLLSKAYSSISPVHAAVYLGFKGDEPGLQEYVAERGWLLDESGLLKPAPVEVEEGGMDTDAEGNDMRIAILSGLVTHLTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ04</accession>
    <name>A0A2T6ZZ04_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1078767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ04"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ04"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="69" mass="7672" checksum="23958CD3A815DA38" modified="2018-07-18" version="1">MAEYIGQKIHMLPTPSAVISRPVLEKNCSRVLQAVDALSVGFRPHVKTHKVGFSSFLLLSSNAYFEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZK1</accession>
    <name>A0A2T6ZZK1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ADP-ribosylation factor family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1020665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZK1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZK1"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="725" mass="81239" checksum="1D8B2D4658EDC15F" modified="2018-07-18" version="1">MSKLTSYLRSLCGAQGPTGRCLITGLDASGKTALLYRMKLGQKVVTIPTIGFNCEDVPRGMDTIIFWDLGGCDKIRPLIRHYMTPGHSVLFLVNTSECIRDAERYKDTIDELTAQVTGSVQVGVVFILVAFSKQDLLTEAQSFQEAAVRQHVKETMDALLPMGAAKGLFSVMDTGFSADQDKGVDELLDALIAGVKRNNVNPVLLPEPGDPVESVHKPTPEHVNDPYVGFAPERFFGMMESASLPVWDHRAHVRGGFYVLIKALGSGLGLWDAVEDFLNILDKMLATDAARAQVEGTEKRFRNTVHRTMTTFYLHSIYLSILKFMELRNPPRIPEHTDFEAFIQVYTHFLSSSLWTTYYSRDLMFSPPAKESWRLPDLKPLPTYFRPTSQTPLSLSSQISSDPNKHYKIFAFLTLKRTKTTKTRRGKVIADALEALNRHIIRQRVRDPTVKSYSATKAYFYIQIFHAAIEGLGTSIDITHLSYDTFALAFPDLVQGNIWREYYKEKVWDSIQARAEFVPPGIKPLPNIIPLVDAKVAAAREVRNKAIGKVPADDTELMLAEHWALSDMQDPSLMLRSHGGMIWWYFSALWTVIRSQSSPHISSSPSPDTSVLTSSLGAAARLLVKDELLKNDSSRGITEKTFWAQIMLQRMVGFKITAGDNLWDRKTCLTDVRRFLGENRGIADQDLWMEYYSAESWCSADAATMFLPPDLKDLRGVVVSGGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZK2</accession>
    <name>A0A2T6ZZK2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1100059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZK2"/>
    <dbReference type="OrthoDB" id="4932428at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="190" mass="21660" checksum="95E1F10C22D7A550" modified="2018-07-18" version="1">MSNYSSSPSDYSYPFSTGGAPGGGSGIISQTEINQMLHTLRSHRVNTLTELRRIEKVLASINTIEYCTAMRDAWNHYVGSNFLNELRGLTRQYPFSNELLENSKWRVYNDPTSNRSWNFAWLLLVKMKNDNMITEYATKTALQPAMWGNVVPDAAGVQQLTNVLTQEWTNAVDRLLKHWSNSPPVTTEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZP6</accession>
    <name>A0A2T6ZZP6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_973046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZP6"/>
    <dbReference type="OrthoDB" id="5324170at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="70" mass="7749" checksum="132442FB591E16F7" modified="2018-07-18" version="1">MERRNRTLIQFDPERGEGDDARKYEGVTPPPRLPELVELGGGISGSRGDEGFYDGPRLNMPEADGFGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZQ8</accession>
    <name>A0A2T6ZZQ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_673911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZQ8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015427349" description="Secreted peptide" evidence="2">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8851" checksum="0C7D30D0F5E98759" modified="2018-07-18" version="1">MIFSLPLLTSFSCLICTAPGSNHDCSTARGSTNGQGIRIPYASRDWCAVRKYIMPFLSFLFLVFFPLHIFPPFHPFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZV1</accession>
    <name>A0A2T6ZZV1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1077978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZV1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZV1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="10166" checksum="8CADFE8E86FA6997" modified="2018-07-18" version="1">MSSSSKPSKTTDPKDSSVADKSKEPQKPALSLEEDDEFEDFPVEDWKDSETDVQNPPGGRLWEESWDDDDTTEDFSTQLREELKKNPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0I0</accession>
    <name>A0A2T7A0I0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1077658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0I0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="139" mass="15696" checksum="42555EDCCA4B8BC1" modified="2018-07-18" version="1">MSSGLVSESIREVDEKIFLNTLYFCLPTGAMHCPRLSLSSLFVPGLFYRNCPAVRTECWCKYRRVFPEEKGVGEGANERDCVSETSDEEIVISNRWGCSFLWVVVVCAVNKVYYPGNCYGSRIIITIALSSIQRSNVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0K8</accession>
    <name>A0A2T7A0K8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0K8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="8380" checksum="AF37775484877135" modified="2018-07-18" version="1">MPLQNPHAPKPLPSNELDRAINPPRNSTNPQQNPSRQIREYTFQNLHGERIQAHFHRHIEPKYQYGSKMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Q9</accession>
    <name>A0A2T7A0Q9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1077545</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Q9"/>
    <dbReference type="STRING" id="42251.A0A2T7A0Q9"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="964" mass="107977" checksum="D235C9BA7A82D817" modified="2018-07-18" version="1">MTEPVASFPTSTLFSSLLEQSRKLRQGQDSGELPPIQLGLSEIERRAKELRRAPGGQRQTDARAHYLLAAGGINTDEVLRDLDSIDFQNAYESSSFRVDTDLDTYLRNRKEQNVMSSIEDGMRRTGRDFDAFVAKNVTIEWEAQKQRIFEHFGLAPRSAAAAGSSPVDLRASGFGGGLSAFGASSFGRSRLNSSFGPGRGLQTSVWSKSTLGNSVLGRSTSAATSSGHQGTLFGDIDPGRQLELSRQVQVRQQRYALAIRHMNEVRLESGNAARGIFPVMKTFGDITGESGTDLLTVQLHDSWKLLSYITGESEVHDANPFSGPRERGFVKDYVINTASDGQEAARIRKHVQKGSRKFLEKQYRDVVESAVAENPQIAKVGGIPSVFHKFRGYINIKLATNKDIPEWDIKNFDFVADVPCWALVFYLIRAGYLEEADEFVRQNQQSFQKLDRSFPTYLHAYCSAGDERRLPRNLLDRIQAEYNNRVKHSEDTKDIFKPAVYKIIGRCELAKRSVPTVMPTAEDWMWLQLVLARETDRSTDPAHEVFTMQDLQKGVIQFGAKHFGTKGSNVGLYFQMLMMSGLFEDAVHYLYSFQFVDGVHFAIALTYYGLLRPTVNPAKADTDLLTLGPKGEKQINFPRLVGYYTRDFRTPNAEEAVDYLCLICLNGDLPSPAGDQHLTICHDALRELVLETREFTKLLGDVHADGTRQKGAIERRMKLIKLDDQREYLRTITEQAAGQANDDGRASDAVLLYHLAEDFETVVEIINKNLSDSIASEDVTLGFSHQAGTSALPSAGSSLTSVDDPVQLAKRMLNMYTNNAAMYSKISIRSREAADVLLSIAEAKKRYQEGKWESCLQIIQDVDVIPIENDADVGSIRRRAQNFGTLHDTVARNVGILLKMTVECCNRLYAELRDSMYADASRNQKLNELKTRAKNVMIYAGMIQYKLPAHVYEFINSRDMTEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1N9</accession>
    <name>A0A2T7A1N9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1190955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1N9"/>
    <dbReference type="STRING" id="42251.A0A2T7A1N9"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="383" mass="41257" checksum="F178A860FA046FCD" modified="2018-07-18" version="1">MLEYLPWKKKAKEPTAVSAVLTHSEAVEKPTTTTAAATTATTTTTTTPESPRPVLSHHDEEFLKKTLEDTDDQPVVILQGSGSTTPSISPSVAPLATPPSETPAVASESDGAEVKGKNKKKEKEEKAAEWKEGIRNRWEGLRRSASSAVDKRKGKGKVEEGDVKGDGKGKEREKDKLEVKEEEKSEEDELRKALDGLNLAAQGGRAFSISPATSLLLDRFTQILKDLVNGVPTAYNDLVELLESSSKTLEETFNSLPGFLQKMIKTLPKKMEANLTPEALRTAAAAAPVAASEVEKLSSIPSLQEMVTKPGLLMGMLKSVINLLKTRFPMALGGANLAISMGLFVVLFVLWYCYKRGREERLEKERLAAGALAGGEGAASGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1U9</accession>
    <name>A0A2T7A1U9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1164720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1U9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17246" checksum="61C5A571BC235AC7" modified="2018-07-18" version="1">MRLELRHDDIVLDGRGQGGWKEDRWRCQDAACLPASGWPAGYTRAVGCARTRKGEQAQNVKNKIASRIEEKGTLFPFRRQDPFLCFFPFSSFSFLFQTESSINRRTFASFCGVRGSPGVSKAALNSTVLVGGGGVQPNRPPDPPRTAIPGREGKGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A247</accession>
    <name>A0A2T7A247_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome c-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1019039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A247"/>
    <dbReference type="STRING" id="42251.A0A2T7A247"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10635" checksum="41BB2A6C3D6B5E4F" modified="2018-07-18" version="1">MGFEEGDSKKGADLFKQHCSGCHTLEAGGANKAGPNLHGVFGRQSKKEGVVWTEEALFEYLESPQKYIPGTKKTVRMKSRTERRDLITHLRKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A299</accession>
    <name>A0A2T7A299_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1121633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A299"/>
    <dbReference type="STRING" id="42251.A0A2T7A299"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="321" mass="35343" checksum="AA18A5B365E6BC2D" modified="2018-07-18" version="1">MSAAYSLARDGILSGETGDGFNCEKCDFKFSGAGALHYHKLRGNSETDARKHFYCGKCRIDFQDEAELKRHLMESSEHAVCRECSQDFHNLEALELHSQQVHLRKPANTHPCPGCDVMFSSISAATQHIESGQCQGNLTAADFRNLINHENNPLAKKGLPADLLAGTTSTHTWRSGIIPSRVKAALADTPDGFKPEELVPKDFVSVLDHALPAKPDPSPKENMGNYWNEMAEAYVCPRPMCRKKFRLATALKAHLESITHDKKSFRCPSCFSCFASSSALIQHAESETCKVKGTPAYNQLIKGATGGLVDGDKKPEYKTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2C2</accession>
    <name>A0A2T7A2C2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_534013</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2C2"/>
    <dbReference type="STRING" id="42251.A0A2T7A2C2"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="3"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="436"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="593"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="721"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="609"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="867"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU81893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="966" mass="106814" checksum="DF9DA8FB7CC23191" modified="2018-07-18" version="1">MLVSLFIKEKLYIGEATIATICGIIFGPSAAGLFDPQTWGNVDQITLEASRIVLVVQCFAVGVELPKKYMERHWKSVVFLLIPVMTWGWLITSLIIWWMIPSLNWLDSLTVAACVTATDPVLASSVVGKGKFARRIPKHLRDILSAESGCNDGMAFPFIYLALYLIQYRPNATGVFYHWFCFTVLYECLFGAIYGACIGYAGRRAIRWAEGRNIIDRESFLVFYFTLALWCAGTGSMLGLDDLLVGFCAGVAFSNDGWFAQKTEESHVSNVIDLLLNLAYFVYFGSIIPWAEFNKPSWGITPWRLVVIALFVILFRRIPIMVALKPLIPDIKTWREALFAGHFGPIGVGAIFVAVLARAELANHSTTPPPREDFAELEKESKHFILISLIWPITCFLVISSIMVHGSSIAVFTLGKHINTMKITMSYTTANEEPNWLARLPRLTPRTSMSIRKPDTDESSDEKLTMANDRMIPPGTLPAPGGIPGGFLTRENGLRDTESPAASRPASIRAKRRKNWESGMGPGGPISDSAIAPRRRRNEEETNVAVPETAAKAGDSYGYSLQPLESKGAEIEAYQEGRNVIVENKQGDVLEQVKAPPTPTDELVGPLDVPRRLLREHQQHHERGKEEESEKQPPKIERAATHEVTDERSALRAAREENKLEGKGRRREPAWAYRFDDNIVVEDEDGEVIRRYKLPKPKRPSAGSRRASTFGDWIGFFGAKKKDKNASEDAQTDDDNDDAKTVYSEGEEEPRGKGIHFRMHDERGRKMSKQEFLHQLQKMDPHARAAMASRTEISGPSQESDLAAALRARAASGQKELLQVPPSASQVDGPKEADGSTPPDGPSSGSSRESSNSGDEQKHPVTSVKSADSRLGDERDEETAAERKRREAALGITGNDEPDSDDDGEPGWRMTDATSSSAQGPIRSPGIRFADQPRSPSTGPPVGLVPRGKTLSWGKDVVMGKGKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2V9</accession>
    <name>A0A2T7A2V9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1075677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2V9"/>
    <dbReference type="STRING" id="42251.A0A2T7A2V9"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="355" mass="39946" checksum="A5E5D52272F221A6" modified="2018-07-18" version="1">MEGLYFNVDNGYIEGVVRGYRNGLLTSQNYANLTQCETLDDLKLQLSPAYGDYLANVPSPLSTSVIAAKANEKLIAEFRYIRANSTGTLAKFMDFLTYGYMIDNVALLITGTLHERDTRELLERCHPLGVFETMPVLCVATNVEELYNSVLVETPLAPYFKNTLSSADLDELNIEIIRNTLYKSYLEDFHNFCVTTPGLAGTPTAELMSEILSFEADRRAINITINSFGTELSKQDRKKLYPSFGKLYPEGSYMLSKADDVEGVKGAVEGVSEYKAFFEQGMGQGAGSGHPKSLEDLFYQKEMEIAKMAFTQQFTYGVVFSWVKLREQEIRNITWIAECIAQNQKERIGNYISVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2Z0</accession>
    <name>A0A2T7A2Z0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2Z0"/>
    <dbReference type="OrthoDB" id="5383833at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="32491" checksum="46E3715202B7F04B" modified="2018-07-18" version="1">MTDASSPQLKQTPTLSTPSPPSSPLKFADTTFITTFITTTTPLTSPHSQNVYQDDPLQKDNQFPPSSFPPYFFPSPPPPPTRHPPPPPQPLRKPSLDTQRPHLSEAGLIIDNLLDPTLTNQNVLTLLQILINYYAKTFLKPQDPINRKITEATTKFLDDHNKTRLEYVARERQYAALLASMDARRTSWPEMADTLSYETLLDLSNVEKFFRLKESLSKIAAIEKLIQARYKALLGVNGIQATQIGKMVAELMRVRAGLGYDICLAAELGVKVRRIVIRDLMLGNHCRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3E7</accession>
    <name>A0A2T7A3E7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3E7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="91" mass="10454" checksum="9C6A85D777C0DB44" modified="2018-07-18" version="1">MGVIECHSDLTKVRTFGSSWYLMGMQRTINSDKMAMLKGRANQRQKKWLEDDEGMEKAKRKAQKARRRVIEAAWVPEDLADLETLASGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3E8</accession>
    <name>A0A2T7A3E8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_969030</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3E8"/>
    <dbReference type="STRING" id="42251.A0A2T7A3E8"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="216"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="395" mass="43108" checksum="4D3F1FCF56158444" modified="2018-07-18" version="1">MDQLPDWDFPSDQSNTSSFTLPLLSPPSSPPPPEKISVVTHIENIITSLTTTLAQTPSTSSLSIPLHSRRQQTTYFSPRTSSILPLPNTHPSHFTSTTFPRNPRQFTCILTLLSILHAHHSSTSTPLPPLLTKRQIYYHNPTLFRSQRNIDYLLDSLAATFRLTRRDLDICAAGKGLVYGEVYIDGAYFGGEGGGGLIPPSFSPESVTLAAGVRSVLLVEKETIFRALNSLRSGIVQKGLVMLCGKGYPDLNTRRLLLLLWKEKSVERVATLVDFDPDGVEIAATYKFGSTLLAHERVAVRGVDVVGVLSQDLISLITATAGGGGGSGVVVTTLTSRDRKKALELLARPWMPAAPSWKVEIQRMLFWGIKCEVEVFYSSTCFAGWVLGKVGKAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3M9</accession>
    <name>A0A2T7A3M9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_427676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3M9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="19459" checksum="9B14731188653493" modified="2018-07-18" version="1">MVDIYHSIILWSNLWYSREVRPCLWEFWLFLICRVNLLWLKCSALFFSVSLGPLADYFHFFPLHILYSPLHVPSPLVFLLFPLLVLLLPPHKILAEYKRHPASSIHRPRTTHNSSIFQREKYSFSPNQLLILLHPPSSSFLFNFFVLFRQIPFNGIPLRPPRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Z4</accession>
    <name>A0A2T7A3Z4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1074955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Z4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Z4"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="22316" checksum="2A40759FC6CD8526" modified="2018-07-18" version="1">MGSYEVSPEHAVASSIRMIQDGRVEAVKLEGGIELAPTISRITSIGIPVLGHIGLTPQRSHSLGGFRVQGKTAASASKLLTDALALQDAGCFSLVLEAVPAPVSELITEKLKIPTIGIGAGNGCSGQVLVQIDMLGNFPKGRFMPKFVKQYANVFEESKKAMKQYREDVRSRAYPAKEHTYPISPEELQEFEEILKQRSAEFEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A525</accession>
    <name>A0A2T7A525_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1074075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A525"/>
    <dbReference type="STRING" id="42251.A0A2T7A525"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="23604" checksum="4868EF24000EB597" modified="2018-07-18" version="1">MATQDTLLIAATKKFVKDYMSKYDSSHNYQHIERVLAQSLAILHATQASSPETHHNENLVILLALLHDVGDRKYSPVTATTSSTAGPAEDFLLSAGASSNLASLLQKLINNVSYSHEQANPQRVAELVKEYPELAIVQDADRLDAIGAVGIGRTFTFGAAKDQEGGMGAVVRHFDEKLLKLADGMKTVEGRRVAKERGERVRAFREWWREEVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A568</accession>
    <name>A0A2T7A568_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_966209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A568"/>
    <dbReference type="STRING" id="42251.A0A2T7A568"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="570"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115928" checksum="DA5F490700CFF83D" modified="2018-07-18" version="1">MTSSPFRRPRFSLLEPFPSDNGDNIRTYPELLAFNAKYNPSHIFCLQGGKDHNAAPLPITFAQAQLSVQRCMGWLAKNVEGIHSPREVNGKVEKAATVGILMGSDVGIVIYMMALLSLGVPVVLLSARLTPIAIAHLLKSTFAGSVIVSQRCQRAASEALASYGSGEKIPNIYEPISYDRFLEDAEWDSLEIPPKYDIVKETDCNVLILHSSGTTGLPKPIYHPHKYMLGYAACHLFEENDKVDGVNFSTLPLFHGFGLLSPSLALSVGKPFCIPPASIIPTATSTLSLLRLSNARSLMSVPSILEDLLYLPQSEGINVLRTLDFVAVGGGPIKSSVGAALVEAGVKLLNHMGATEIGAIAPIFLPGPDYNWRYLLLRKDIGLRLEDPGDGSGLFKLIGRPFGWNQEFPVQDLLQCNPRAPDSQFKILGRADDLIVLATGEKVLPRMMEMTVANDCRVKEAIAFGDGRFNIGLVVEASIDLNVKDEGEMSAYVEEIWPSVLAGNEFTDNHGKITSKGMIVVTTPSHKQLARTDKGSLARKTIAQDFAEEIDAAYRKVEIEGIEAIPDSVEDKKTWLKALVGDIIKISPNDPTWSDSDDFFELGMDSLQATILRRKILASITKSGCEFRELSPDFIFKCPTINTLHALLSGNVSDSGGERAERMNEMVRKYVSNIRSLPAPTMAPTSIVLLTGSTGSLGSFLLAQLTALPQVSKVICLNRRANSPSSKDLHSRQKTALSKGGITVPASSWEKITIHEADLKIPSFGLPDSDYDSLRSVTHIIHNAWPMDFNRSLESFEPHFHATQNIISLALSANESNPQNKPRILFTSSVAAVGRYPALTGSALIPEEPMYDAQVTDHFGYPEAKWVCEQLIEEASRIHTGRIETASVRIGQLTGSESSGAWSPKEHFPSILKSSQTIGSLPDIKGTLSWIPVDRAAKVVIELLFQPSPPDPVYHLENPMRQPWSDLLVLLSRALDLPSKIIPFEAWLDKVRSITDVEKNPAGKVVKFLEEEFTAMASGAVVLDTKKARRVSRTLAGSGGIGSRHVDLYVKYWRSVGHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5B2</accession>
    <name>A0A2T7A5B2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_966204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5B2"/>
    <dbReference type="OrthoDB" id="5405293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="9514" checksum="C43E5748F0760E19" modified="2018-07-18" version="1" fragment="single">RDNNNIARRLNSRVVDGYDPLEPFYGADGQPIPDFPDTWADVAHLTSRSMNSLLVALGLNTRGKLPQRRYRLGRHIGVVKILEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5C8</accession>
    <name>A0A2T7A5C8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_253988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5C8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="8949" checksum="02A72DA1FF9F1D20" modified="2018-07-18" version="1">MGDPGTNSAGPSGPRLTLEPSAGSIHELSQLSPLSPTPPQESLTRFTDWETIGEQRDFYNEKDCLHSNHNLASEKLKKQKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5I5</accession>
    <name>A0A2T7A5I5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1073621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5I5"/>
    <dbReference type="STRING" id="42251.A0A2T7A5I5"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="898"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1068"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1123"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="544"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1193" mass="133736" checksum="6857FFCDDF1172E8" modified="2018-07-18" version="1">MPPTRRTPRRGGWKPGTPIKPKKPRIPIELDAAFFATIDLLNDLSSLCAVGSVDLEIPRRPAPGMEAPDGWNWLEIPPIRFPKRSMADNLIHNLIQLASLGVLRCTYVMIGDSTARARIYLLPDDVGRRVIPRDSREISKFRREVLYALDTSKAGWQGLKVEGRKPLVAPGDAHLSLFYLFNTLDSPNPNPKAEWVKDRNTTDLMNRVLKKPIVGMKNPLYGYQKKTVAMMIQRELAPENTQDTRFRCFAGPLGQKYYLDLETTEMLIEPRKYEDVRGGILAEDTGTGKTFICLALILATKYQYSFVPEEYEEPPRLPAIWKHSLGWGEFKDDLGAVNVAKLRAAHAFYEVQPPSRSRSKRYSPSDVREKIYLGTGTIVVCPPNLVDQWKREINIHVEEKALKTLVLVKSSEEIPPVAELLEYDLIIIARPRFDMEEREGRDRAGRRESGGKPLTCRCPYKGATRTADCVCFDRDAVYKSPLMSIRWKRLIVDEGHSMASSSTLMNRGVCVAQRLPVERRWIVSATPVTGLLGMSSGMNIGETEEALEARREQELEERRVAQTNEANDLEKLGRIVCDFLRVRPWALPSEGQSNEYASWKVYISKGFMQRQPGSTDCVRSILQRIMIRHRLKDVEKDVALPPLYHTPVYLEPGFFERLSMNLFLGGIASNAVASERVDKDYMFHPKNRGPLRELTNNLLKRSGFYWMGHSSADVQLMVSVSQRCLADPTKHHSEQDRELLESAIASGSRALDNPVWNACIRNSEMAYSVLHFPKSIVAEWALVREFENPCPIGGKSVQDVQRYVNAHAYDPKLISKLGDKVGVAAADAYLAASTRKNGKSKIASTVVDRRNTPEHSANGAEVKPNPKSILKRCTTPVSTVPEDSPLAKTEIIGTASRKLTYLLDKVLEYHKTEKILIFYESEDVAFYIAQGLEIIGVEYLGYQKNLPSHEKAKYLVTFQFSQTFRVFLMDLSQAAFGLNISAASRVFFVNPVWQPSIEHQALARAHRIGQKRPVYAETLILNHTIEREMWDRRQGMTAAELDLSKGAAANDSKMRDIISSTKFLKADDVEGEVDDSGNPSTSVSSNRFANLKSPQALLGPGKHGGVYSHEGLDDRLRKTYKVPHDRASSLTPMSPDYPDSDSDEIVSDLRVVPPKRRASVASSGAGSSGRKKRRSSNSSSSSAGAAKKAVRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5R7</accession>
    <name>A0A2T7A5R7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1119874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5R7"/>
    <dbReference type="OrthoDB" id="5471005at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="22659" checksum="6156E028B6140B02" modified="2018-07-18" version="1">MAANMFRFLIRPQEIARVQAIGYLQRQPTHRRLFSADSKPEKEDRGGEEGSTLKKRLWDRVFENDKPLADLRKELKDHEIAIHKAIKDHEIATNNAIKDRETTANKAISNLSARVGTGFAEVRTQFAEVRTDSAEVRTDFAQLKRKISFMQWQIGLVGSAVVAFLGFAGYAIKRAMDAQVVTSVGSEPATESKDVSNGVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5W9</accession>
    <name>A0A2T7A5W9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5W9"/>
    <dbReference type="STRING" id="42251.A0A2T7A5W9"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="13325" checksum="B90DB83526B5D094" modified="2018-07-18" version="1">MFYTLFSEDGRMLLSWAGGPVGWTDSTEEEQWPNLEDDDRSDKIDEDEEEVNHSGRMIFRAGRKKKEEVVGKPGPDKSEFEEAERSSEDGDGEDSLDEREVTIVNKPSSNILKNPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Z9</accession>
    <name>A0A2T7A5Z9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1039583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Z9"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Z9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015370270" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="49"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="531" mass="58972" checksum="D42942CD2CF17D0D" modified="2018-07-18" version="1">MMRIGLKETLLSLLFIGGRSCAALYNSSYNSSYNSSLPIIDLGYVKQQAIEYNQTYDFYHFRNIRYAAPPLGDLRFRKPKPPLSQAGIQNGDIPFVESTCHQVWLPFMGAAPFGDNFGVEDCLYLDVYVPASVKPGDNVPVLIWVFGGAYIVGSKEMWGDPAHLIQSSDEPMIYVSFNYRLGAFGWMSPPNVTDIDANIGLHDSRAAMEWVEKYISKFGGDKGKVTVMGESAGGGVIMHTITSNRGEGKKLPFQQAIVQSAGFYPIRTQYANQNAQYDKFKKHANCTTLKCLRGAPTEVLLKANKDILMMLSVVELGAFSPAVDGNYVPDIPMRLLSQGKYHHELKSLIASSMGFEASVLFPTPDTVTNSTLDSLINRFYPLAPESLKQQALTLYPYQGPGIPEWLRASAFFGDTVFNCNQIWLAKSFQKSYRYVFNIPPAFHGEDVAYTFYTGPDAKIANETTAIIHQKFITNYVTHGEPGCEMGACFPDYGNYGGSANALAMNVTEIKVVRDPWATERCDFLVDLVEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A649</accession>
    <name>A0A2T7A649_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AIR synthase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1146875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A649"/>
    <dbReference type="STRING" id="42251.A0A2T7A649"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like C-terminal" evidence="1">
        <location>
            <begin position="73"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="365" mass="39723" checksum="2732ACF261937FEE" modified="2018-07-18" version="1">MLEAPIGSAAFNNEFRRPCIIGYFRTLTTTVEDRNVKETRGYHKPVMLAGGLGIIHPIHAIKETGMIVPSAYLVVLGGLAMLIGLGGGAASSITSGEGSVDLDFASVQKGNPEQQRRAQMVIGACVTLGEHNPIRSIHDLGAGATFELREVESADKGMSPLQIWCCEAQEWYVMAVSEPGLKTFVAIAERERCGFSVIGRAEGGGKSDQRLALKDRDSKDYPKIIDLPMSTLFKKPPKMHKNVTARVLDHAQFDNSLETYLPNISLPERLVEAVDRVLKLPSVGSKSFLITIGYRTGLLLGSSLGIRWLALGNGREANSSSHLPRSICVYVCCRVYHQLGRGRHPRGTKACPVVGKLDGSWQPSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6E2</accession>
    <name>A0A2T7A6E2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_965046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6E2"/>
    <dbReference type="STRING" id="42251.A0A2T7A6E2"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="111"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="464" mass="52690" checksum="559BBCFFB51643D6" modified="2018-07-18" version="1" fragment="single">KDLLIGRDPNKSSISLEDLTISRQHIRIYSVIFEEESEPLVYCEDISRSGSLLNGKLIGTNNSVLLSHGDVVRLDKHNSFCFIQPSALNSQRPIFDTIFERERTRLTPDYIITNRVLGKGAYGRVHLAWDLISSRQVACKVVGYGPNLVQGNPRKAGDLHMREFEIMASLNHPNILALHRVIRTEHNIYMFSDLITGGDLFSRLDSGPMTEIEILPIIYQLLKALEYMHSRGVVHRDLKPDNILCTRHANGSRIVLGDFGSARFFTPTTTMRSQCGTLEYLAPSVPLSYLRELITPHLVPSPMGYASAVDYWSLGAIVYTLLTNTTPIIGPVARIPTRLQDYELTRLEDNEEEWVNISPEAKDFVRRLMTIDPRRRMASDEAQCHVWLARHMEDLEDLYGRATKEWEPLDRTDFKVEEKTIHGNADPFHNRPASFRSSISQVPDLLFEGSLSSDNFSAEPRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A817</accession>
    <name>A0A2T7A817_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_962232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A817"/>
    <dbReference type="STRING" id="42251.A0A2T7A817"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="40223" checksum="B17A16277244A812" modified="2018-07-18" version="1">MQAAVGSFIPSLKVAFPPSSWLALLPSPSTASPTIPPSASKYPFTISEPLYTAFLDPRVPLSIAAVYAAAVHLLNSRCNGKPYYIATTRIFKAFVLLHNLFLAVYSLWTFIGMAGAINRSIVTSRGVPGVVESLCKIRPETRFEGVEIREMEGGVGLWEEGLAFYGWLFYLSKFYEVLDTAIIIAKGKKSSLLQTYHHAGAMICMWAGIRFMSPPIWVFCIFNSLIHTLMYFYYTLSTVRVPVPNALKRSLTSLQITQFVVGGSLAALHLFVYFTPTTYLSGSLTEAAPSSSASASFSDHGMPVDVKVPGMVHCLSNPGEVWAVVANVIYLTPLTYLFVSFFVESYTKRGKTKKAAKAATLAEKSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A871</accession>
    <name>A0A2T7A871_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1060539</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A871"/>
    <dbReference type="STRING" id="42251.A0A2T7A871"/>
    <dbReference type="OrthoDB" id="201621at2759"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="63"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="358" mass="39668" checksum="F9BF3CEA75C5E64E" modified="2018-07-18" version="1">MSPSRGLTFARTISRAHQRQFHRHQSTFRGLSSSKIPVQVYISKSNNPYLNLSLEHHLFQTNPPEIATLLIYTNSPSIILGRNQNPWVEVNHPQFPSTSSPPLIVRRRSGGGTVFHDLGNVNYSVAVPTSTFCRDKHAEMVVRALRKLGVAQAVVNKRHDIVILPDGMAVEETRLAQEVAGTRKISGSAYKLTTRRSYHHGTMLLESRLEDVRGYLKSAAKEWMKARGVDSVRSMVGNVWVAEEKFVEAVVEEFGRMYAGEEGAGILKNTMASKMDRMDEEVGVGVCWVGGEASEIEEVQKGIAELKSLEWIYGQTPQFTFSVPAPKANDGPIPPLPPSKDPPLREVTAPPVPQPPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8J1</accession>
    <name>A0A2T7A8J1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8J1"/>
    <dbReference type="STRING" id="42251.A0A2T7A8J1"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="30944" checksum="21430BB5A3DB8B98" modified="2018-07-18" version="1">MATKTPRLVVCGGNGFLGSRICRSAVSRGWIVTSVSRSGEPNWNTAFGSPTPPEWSKKVTWAKANLLSPPAYKEYLKDATTVVHSMGILLEADYKGALSGKENPITGVWRAFNSAKGISRNPLKDGGGPEKSQLTYETMNRDSAITLAEESIAAAPETLSSFVYISAADGSIVLPSRYLSSKREAEAAITTLSRAKKPFRPIFLRPGFLYDSTRPVTMPLAGLMGVTSAVNSLFGGKLPLLGAAGYKPLKVGVVGEAAVEAIARESVKGVVEVKDIEELYSKAWRRGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8R3</accession>
    <name>A0A2T7A8R3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1070640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8R3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="65" mass="7072" checksum="DE63E150FE59FA43" modified="2018-07-18" version="1">MALQSLLKGESICRIPGALGMRSGSPFTTAFYAIPSVHRQKDVSIPAFSMALQSSLKGESLWRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9X3</accession>
    <name>A0A2T6Z9X3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1104423</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000591">
        <property type="protein sequence ID" value="PUU72298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9X3"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9X3"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015374378" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU72298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="446" mass="48024" checksum="55DAA829D589DA73" modified="2018-07-18" version="1">MKGFTATLAATASLLFSGIASSKVTDPVTVKGNAFFVGNNRFYIRGVDYQPGGSSNLADPLSNITVCQRDISHMKDLGLNTIRVYTSDNSADHDECMDLLSEAGIYLILDVNTPKFSISRDFPVASYNEVYLQHVFATIDVFSKYTNTLGFFAANEVINAANSTRAATVVKALIRDMRKYIGKHVNRPIPVGYSAADVAENRREMAYYLNCGSDDTRSDFFAFNDYSWCGPSSFVQSGWDKKVENYTGYSIPLFLSEFGCNLVRPRIFNEIKALYSTQMTGVFSGGLVYEFTQEPNNYGLVQIDGDNLTTLPDFDNLKKQYSSTNNPPGDGGYQNNLPASNCPEKSSLWEATNTLPDLPSAASVYMNNGAGTPKGTNGASSQFVPQNHKDYSLPGESGAPAPSSSASADKNKKGVAASGMAGLAAGGLWMGVTVGLGTIAGAMLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA43</accession>
    <name>A0A2T6ZA43_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_696778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000579">
        <property type="protein sequence ID" value="PUU72306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA43"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015539365" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9513" checksum="08136379826D014B" modified="2018-07-18" version="1">MSRTSQVVDIYLVPVLVLLQAGVQTRYRLGDSRIHFRAAPTGSTRARYWYLTPPRGKHSLPKSECVIREGNVGYCCGFMYVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB87</accession>
    <name>A0A2T6ZB87_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1136782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000470">
        <property type="protein sequence ID" value="PUU72755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB87"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="131" mass="14055" checksum="40D45357B5497D45" modified="2018-07-18" version="1">MSSTTLPKKTQRGFKFYSGYRHLNPSNGTQECKPIDSIAPRARTQPIPLSFGQRSPGHAPAGSEFFDAARQHSVIARQTTGRVSEGDSDIGGTEAPAGAGVFFVTLVFPLLARLLLRKGKGNSRGKAVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBD6</accession>
    <name>A0A2T6ZBD6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1136697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000464">
        <property type="protein sequence ID" value="PUU72801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBD6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBD6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="134" mass="14343" checksum="5B66CCAE0F239E08" modified="2018-07-18" version="1">MNFLLSPRARSSSMGVLGTDRGKGKSDEDGDFNDAPNSLRGKGAGSRPDTTEMARLQPPAARRTAILQPRPLTRSPIFAKIISQWSSIIQKGTSRTIPLVMPKRILVSYITPMASLLGISIGGIYILATGSMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBH2</accession>
    <name>A0A2T6ZBH2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7881 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1166361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000455">
        <property type="protein sequence ID" value="PUU72848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBH2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="1">
        <location>
            <begin position="86"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="167" mass="18485" checksum="68C1348927987993" modified="2018-07-18" version="1">MPTVKEHTPTIIGPQDQLIEGLNGSSSRDGPVLTEIGMTEDEGEGEASILPKPRFLIPSSQTVTTLIGQGKLVYMALPPDACRSMWRNAHIYATNGHDNLIGGLWVAEGITNANLYSMVGIICPFTDTFYLRYYTVGLLLVERNQNPLQRGNYLIVTNDRSLLYFSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBS6</accession>
    <name>A0A2T6ZBS6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">N1221-like protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1096236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000440">
        <property type="protein sequence ID" value="PUU72933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBS6"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="537"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118499" checksum="D8CE874E44DD4900" modified="2018-07-18" version="1">MSHSDIMIQTSNFMSGNTDGNSGGGGGGGGGGDTPIVPSESAADLTNRIRIDTSKIKEEEPSPSSTGGGEGAGNDAGGGQPGLTQDSLSLMQLKRLVVEAPRLKQPEYAFRYSSTDITTAELNEWFSYSLANDLSLLLLSKQTFEETYAVLSLPPHQTVESLVGKRPPRWTTSKDVKRKRFISRCADLLEHTSQRERVKGLEGLAYVVQGVFGETVSEEDHLDRIKKNVALARQAGLVEALFNCVRGSVGRELEYAAAGSSSRDEAKEGDRGWNRKELRYALTVLYFLVEVTRRHDEDAGGAILGMDQEIESLRDEIADLPGESGLLGFLAKTLGRLRWEDSVDLPLMNILLLTWKTMLLVFGEPDRHLAKVKTYARGLAGLDPEVGKGLITASPLDYHVFRQDIMAKYPAYDPPKPLFPFELATNSFLPSSAINTAAGRTGGNGDVLLGGKGGGENLGSILNKAVHIATPAPSPPPSPGGVGGKGGKKQNYQTNNNFPFLYPPSSSSEIDKKFAGKCWWKEDEETFSRAEGESGVPTSIKEAGDLFSGRVRSTLAMKHMWDEREAFLKFQRGWDVDEEILRERKEIEERDRRWEEKRLESVEEFYRAALPQLQSFVIVLLKVILANVNAPPMQPPLPPPPPSSQQGLFPDKEDSEGNSQRGPAAIDSTAGRVEYAGSSIRNSWNIFGRAVPGVSRANGDGGEGLNTISEDGSEQSSNGWEKGREREREKERGKEREKEREKERVEREADEKRRLDEADAQRIREITSKAVSAILVGMLKWFRASHVLKFEYLTQLLLDSNYLPLVLKLLNQQDIVQTVTTKTDRKDMSFFNFCSLHSSHPKPKSKPPTDPSNSYLDSSPDEACPPPIPKFKREQKEPDPPSPPPSGAPPSHPPEAITDFSWRNFFTAINFIRIMQKIVKNKSHRNLSLVQYKSSAILRKPLKCPQEELRLYTLKVFKGQVPYCGRKWRQSNMRVITSIYLFCRPELKDDWLSGGDVDSEVEESLPQEQALRSLTHFYNVRRYPKSMGADMEMMEMERDFFRREIDKMEVGEWDAAGMEGWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC16</accession>
    <name>A0A2T6ZC16_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_587419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000426">
        <property type="protein sequence ID" value="PUU73023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC16"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015679821" evidence="2">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="17372" checksum="312E60538CB25E3E" modified="2018-07-18" version="1">MVFLFLLLHSLFSISLSSHSAARRRQSLASERFNFLGKSISGTILSFYQQSLAPLHPKSRVIPCNPSFYASTGANNTTSSCSPLTNHAASPTARPPYLLPSLPLCPLSFFRSESRLTKPGLLLSHLTYPTHSPPTLSLHADRPTSPQHTSPHLTSPHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC80</accession>
    <name>A0A2T6ZC80_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1111414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000417">
        <property type="protein sequence ID" value="PUU73069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC80"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="123" mass="13855" checksum="7036EE100D65E7EC" modified="2018-07-18" version="1">MSTRKRKQEAGAGEGEEEEEELQALPSDVSDEEEEEYVDSEPEDSGAEEEEEEEEAEEADEEEEEDTAEASKPKRRKLEKDAEDEAEAEEEEKEDEPKDDKEGEEAEAEAGSEPKAEAEKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCG6</accession>
    <name>A0A2T6ZCG6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chitin synthase A</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Chitin-UDP acetyl-glucosaminyl transferase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Class-V chitin synthase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1135736</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000407">
        <property type="protein sequence ID" value="PUU73173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCG6"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000010">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000014">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1400"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1433"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1461"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="769"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="17">
        <location>
            <begin position="1685"/>
            <end position="1741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU73173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1745" mass="193286" checksum="D32254A5429A847E" modified="2018-07-18" version="1">MSFSNRHSIYSATSASPYGGGNAAQTSGTVTTSSLLSALHNAYQSSIPHALDASTTLVVNSSNSGGTGGYGTGVVDETLGTRAWEHARRRAEDQTILLGSLHSNSPSLLLPILGTLPSPPDILNTSLALISAFTSCLTPSSPFPVPYHNGLAVTLQISLSGTITGAYISISTAGLDTQNGLLRIPAQAGYRAFDVFYYLLSAASTPAERQGLGLQSPEKYSLLARSGTYSLPSYLPTADDSAAAEDWRANLRAVGIKGSLLRGLLSALAGILKLGNAIGLLVDEEIIEEVCEDVSGLLGIEPEILAKKVGDGERELFIAVVYEAIVEWIVAKANDAIAADFAVRKEAESTSEGSQEGDTVQITVLELPNEKMAKALCLKGVFDDESGLNVEMKLDGVEIPSASGTVYREMKGSWSEAEKEGLVGNSREREYERDRRENVIEKTGRDAEEGGFLKELLFPAEFGRSPEATKFEAVQLLAASRVWWHLSLFPSDDIPSGLQPVPWSASAVSRQLRSWRLPEWANRRTKHLDFTADFDFDEFSVRYSPLGCTSGRDGVESWVIERGWSNGEVVVGRERVWMREGSWWEAENMLDLKQPGIPPNMSGMGAGPMDTGYAQNTNASGYFGQMGGMGLSPSGSSSQLLQNQGSMGGRGLLGSSPLAHNQDSPEQGPLLSKYEQERYAGKLDPEMATPKNIESVPTSKTRKIWIVVVWAMTWWIPSFVLRYVGRMKRPDVRLAWREKFVLFFFIFIMNAAIVFWIAFFAKLLCPNYDKVWNRTEVGYHQGEGDFWVSIHGQVYDITSFWTLQHSDSNIKTTRDNMIDFAGLDLSAYFPPPIYLGCPDLVQSNLINLQYNDTSAQRLGVGVHASGPRNAQDPRSKLHSADWYSQTFLPRIKEYHKGDLVWDRKKIKKDGVANNKPWGIIDQRIYDLTDYFYTADQNPNSGAANVPNYNYLGSTLEGIFKNNPGSDITKLFHEQLNATAQVQTLRCLNNLFYVGKTDFRKGAKCQVNSYLLPVFAGIISAVILVKFLAALQLGSKRRPAMQDKFVICQIPAYTEGEDQLRKALDSLTALNYDNKRKLLCVVCDGMIVGGGNDRPTPSIVLDILGVDPKTDPPALPFKSVGEGSAQLNYGKVYSGLYEYEGCVVPYVVIVKVGKPSEHGKSKPGNRGKRDSQVLLLDFLNRVHHRTAMSPLQLEMFHQINNIIGVDPELYEYLLMVDADTSVKEDSLNRLVAACANDAKIAGICGETSLENEERSWWTMIQVYEYYISHHLAKAFESLFASVTCLPGCFCMYRLRTPDKGRPLIISSKVIDEYSDGNVDTLHKKNLLSLGEDRYLTTLMTKHFPYMSYKFIPDAYAHTAAPETWSVLLSQRRRWINSTVHNLFELFFLKEMCGFCFFSMRFVVFLDLMGTLILPATCVYLGYLIYLIASKTGPLPILSLVMIAVVYGLQAIIFIIKRQWQHVGWMVIYILAFPIYSFILPVYSFWAQDDFSWGNTRIVIGESGDKKIVATEDEGFDPRSIPLQTWDDYAAQNSLPGRRGGGAPEKFSGGYEDAVELDDIQSTYSSVKPASTILTGLPHMGGAHPYMPPQSPAFQNRQSTYSAYTSFTGHPGDHNQHQRLMSMGGMSNRDYWQDGPGNRGAMSTGVPSTDNLLAMNTPPPRAPSRSPLDFANSRPTSQMDFMRAGGGPDDELIVEAIRAVLREVDLETVTKKQVRALVEQRLQTECQGERRTFLDRQIDTELANMPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCP6</accession>
    <name>A0A2T6ZCP6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1135616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000400">
        <property type="protein sequence ID" value="PUU73216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCP6"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="241"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="495" mass="57227" checksum="E55C3E21E9C131C8" modified="2018-07-18" version="1">MPPSRPPKKYLSPDERFRIISLRIQQKSWEEIVRETGEKKSTIRNIVTHFLKHGTYHDLPKPGRRRKLDDRGLRRLERAVLKNPAATIQDLAREATLDSGENAVKRALRELKFGVFRVKRKFWLSKEAMMKRRRWCLKKRKWTEEDWRKIIWCDEVRIEVGLRSGPLRVRRRRGTSLWPRYIQPTFHSGRFGISFWAAYSYGSRTPLIFLRRRRPEEYKRERDRGGLNATQYRNEDNSGREDASYRPTLFCDGDPGAGKSYIVSLVIDKLCEEVVGGDPTVVCFYFDFAARNEQSPVNMLGPLLKQLYLSRGLQVSEILKMLRAITAMRRTFIGVDALDECVLEYRMVVLESLGQILQGSASTRLLMTGRPHVWSEVERELGGAAPFVFIPATDDGVLRFLREKLRRDTMPNAMSSTLKEDIMESIPAISTETFLLASLHVRAILRGTTVARRRKILKSIKDGVELGEVYGAARERIKARDKEKAKLAMAALTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD62</accession>
    <name>A0A2T6ZD62_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1095234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000386">
        <property type="protein sequence ID" value="PUU73344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD62"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD62"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="161"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="219"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="322" mass="35989" checksum="EB94D684CABFBF52" modified="2018-07-18" version="1">MVHRTPLRLLLRAPNILPLLPLPRNTLQQQSRKLSTTMPLQARVPPMEKISASSPSKGGPPRTRAKYQYRSPRYYRGRLAPNMPPPSASPSSRLYVPGPFVAERLEDHYWNTLAPDLQVLSYVHKQNPTFDIEKDYRQLTALRLPPKPTRQQLPALRTFRNIPRLKGITVHSMVRQAMKDSAHLHAAGMVVQSITGVRASVHKSKENIAMWELRSGKTISVTAQVKGRSAYRFLSQLIDVVLPRIKDWKGVAGGSGDSSGNITFGMSSEAVSMFPEIEVNYDMYPPKMVPGLHITIHTSAGNDVDAKILLKAMGLPFDGNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE32</accession>
    <name>A0A2T6ZE32_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1161790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000348">
        <property type="protein sequence ID" value="PUU73750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE32"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE32"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="427" mass="48173" checksum="FF237F200D70DD0C" modified="2018-07-18" version="1">MSGKRKTGMRKYRKTIRKRLYPKADYSRELLVMAILAKRPSSLVKFLGWFEERKTLYIAMEYLEKGDLTKHIGTPLTQEPVRNISKQILEGLDKIFVCVKLADFGVSKQILAQAITFHTQVATPVYSAPEVLGLDYNSENSEYTNSVDIWSLGCVIYELFVETKLFISEGQVSHYYFCKWPFPEDTLKKLSPPIDDLGISLLKSMLIIQPEDRPTLADALNHGWLAFLQSDKKDNGDNENERRESSDESALSGKRKNRLAIFNRPKIKRTERNSITQDRITRIRRCAVSVVNTGSQIGADSTIPESMPGTPMVALLDATSIENPVVQMGLQTPELIPHNFQATHSKSPKVASRSPNTKLPLLTNRVANKNQMLNPRPSANDPSRPNSYSRNRFQSATSTNGPTQHVPEKTHKAHSPILDETASRITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEF6</accession>
    <name>A0A2T6ZEF6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1117180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000337">
        <property type="protein sequence ID" value="PUU73862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEF6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEF6"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23655" checksum="2464712F6F617471" modified="2018-07-18" version="1">MLRALYPGQRNGYAQIGKLEPWIDKAFGEGFDEKMIRDKFLGKRFLILAVQSNSSHCFVRFGSPARAARELTLRATLIPGSSRPLKLNYASGGGLAGRRGMSRGYGVVSSQMRDQQSALTKLSPTCSYGAPQPMNQFTDPKCTTVFVSRHSGYVTQGEFRSLFPGFRRIFMLRFLRGKADSRVRLHWGRSQRNSDPTGTPYRPTPPPPVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEH2</accession>
    <name>A0A2T6ZEH2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_497169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000335">
        <property type="protein sequence ID" value="PUU73897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEH2"/>
    <dbReference type="OrthoDB" id="10424534at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="269" mass="29719" checksum="0CEEEA7BAE2C6670" modified="2018-07-18" version="1">MHVFRSPILPRPLRLLCVVDSGSAFTSASAPPSLLLRCSFSSAAVSQSRSHRPTSSSSPRPAENASPVPEESEPSQVRDKGNGSVIGKGAVSSSNSNHRSSTIKGSRIGNWQSSLFDSLFPEDASGPIRRKPIGRLDISEDSTYLPDPMEGLARRKRMDNGNWAKSRAYGPQEKMSRYGKLELGRKKPRGRLTTAPSTRRISPSPIELPSQFFFLFFLFLSSELLPFFFFLFSSFPLWLQLRAPFISSASSSHFPPLEIIDMVFPGCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFA2</accession>
    <name>A0A2T6ZFA2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1103609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFA2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFA2"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="555" mass="60462" checksum="1457C5D45BA0C960" modified="2018-07-18" version="1">MAFAGQTPTIIVLKEGTDASQGRGQIISNINACLAVQNTVKSTLGPYGGDILLVDANGRQTITNDGATVMKLLDIVHPAARILTDIARSQDAEVGDGTTSVVVLAGEILKESKPFIEEGVSSQIIIKGFRTAARLAENKIKEIAVRIEKGDRRDTLLKLATTAMSSKLIKSNSSFFSKMCVDAVMSLDQESLNEKLIGIKKVPGGGLQDSLFVNGVAFKKTFSYAGFEQQPKSFNSPKIVCLNVELELKSEKDNAEVRVEQVSEYQAIVDAEWQIIFQKMEALANTGARIVLSKLPIGDLATQYFADRDIFCAGRVASEDMDRVIQAVGGAIQSTCSDIREEHLGSCERFEERQIGGERYNFFEGCPQAKTCTLVLRGGAEQFIAEVERSLHDAIMIVKKAIKNDYIVAGGGAIEMELSKYLREYSRTIAGKQQLIIGAFAKALEIIPRQLCDNAGFDATDILNKLRMRHGKGETWAGVDIVNEDIANNLEKFVWEPTAVKVNAIQAATEAACLILSVDETVKNQESEQPQGGPPMPRGAAQRALRGRGRGMPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFB2</accession>
    <name>A0A2T6ZFB2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000320">
        <property type="protein sequence ID" value="PUU74162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFB2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="60" mass="6964" checksum="C7F8F9C50E0819B4" modified="2018-07-18" version="1">MYDSTMNRLPYQIDPPPPYRIIARNQQGKRKTIPTPSPPPTQYIIPLRKHIISISPEHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFE2</accession>
    <name>A0A2T6ZFE2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1033631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000319">
        <property type="protein sequence ID" value="PUU74176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFE2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFE2"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="281" mass="31351" checksum="82D70E1C21C7CDC6" modified="2018-07-18" version="1">MGITGVGKSYFIREVTGYSEVNVSGGLYSSTIRVQPYSFEYLGERITLVDTPGFNDTNRTDTEVLKEIADWTSKTYKKNQLLSGIIYLHPITHTRMEGSAMRNLRMFQKLCGQQVLENVLLTTTQWSNVNPAEGQAREDGLRDEGLWGGLISKGATLQRFYGTRESGLELINVLVSRTRKPLHIQDQIVKQRMTLLETDAGRFLNEELAAQEKALKERLVSLESRFQEAMGTVGTVGCGLKSLMEEQAKSQKKLEMAEAGMKLLAACSGGKIARSENESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFF3</accession>
    <name>A0A2T6ZFF3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFF3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11276" checksum="6B8C61508F0F7BB2" modified="2018-07-18" version="1">MHLHLGGHLPPGVIQNLWVKPGFQQRAAQCSVVMSALFLALGFPPRRVAVVLASVHAHPRLLDELPDELLKAPAPAEASKSQVEGPPDQRGHAELVGGSVDLGSVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGU8</accession>
    <name>A0A2T6ZGU8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Shelterin complex subunit TPP1/Est3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1092026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGU8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGU8"/>
    <dbReference type="OrthoDB" id="5397521at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019437">
        <property type="entry name" value="TPP1/Est3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10341">
        <property type="entry name" value="TPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Shelterin complex subunit TPP1/Est3" evidence="7">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="858"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="903"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="943"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1111"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="945"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1158"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1222" mass="133466" checksum="638325A63D59183A" modified="2018-07-18" version="1">MSDLLRSAWLAGSVCKSLTGWRTKKGSAQPPQEYSISPEGDLLLRGTKEGVLQLTKFLTYENPLTAQLSDKYFHINCEFTPTCRSRFEAEHGKDLLKIKGALIQLLEYEIRFVGSDGALSEKGITFGGQLATKGARTSGTRKSLTGSSKHNPPRIPIPVFVVQKFVLLACEGERTWGTPKTITANAKLEALLAELPRRKISVGGGNGDRDKESRQLAQQGPGTATTTGRREVAGDQGDEDDDDEDEDSQPFATQAPNKFSYFDDLDFETQSQFRAGAPAGSGPSDSLPSSLRVPQKNSRPLKRKEVSFEVPLEKSAIQPKVQRVAKLQKNHNSDTFGHKSTNDSLMLHSGWQGMVEVTEEDSTVPEDQEMELQQETAWYPPQTNAGNPRNSAYDIRKERFILEKHRPGSIYFGKHTARKTCLTQQKSSPDLAESEDAESGVSWPSSPEYQDSGFVGRRLTGTPPHSSMTSPVRSLGPSAGQAPKGRSSGSALKIPVGSGDSSILPKNGGSQQLTSDKKSSKRGKTSGTSLASSKRGSPSFRGGLSKRVTRGANGISKRVLPDPTNSVFKRPRKRPNLKKPSYDSADDFEDLEEVDYSDQSSGSRAREFSVEPPVPVIDPYGRTRVAKYGILGAQQVEIWDRNRKLAKKPDTSSGPVDEDDSFSDTSFPDPDILEDLGIFKSNGENGTKHGFSEFVDNHPHEGDPHSTSCDVPPSLEPNPMESLLLSNHDGDTVGGKPAGRSFGGGSESFEAPLETGHNREPSMSDDENGGPQQPPLLSSQTAFAIASSPAKQGDGQKEAVLNRELPTNPTKPPDGSQELDKGKGLSRLEDAPRNGSGLVTGKQVSLDAEVCSPQFKQSKPGLKEMYRSSSPTPAATIQVKETPYRGDGRPFLPWERVVYMNDDSDQEGIPGTEGPFSTVQVPDSSQDQLLRENQEYRANLEVQVPASSDGVQMQKRQTPATLSKLEERIPSSSDEIRCLKKVDILKTLEKPGKALNDSPISTQSTKHIAPPFSPTANTDKGPKISLPISVPRVLPPELTNPEPPASVRTKAASIIDISSDEEVPAPTPPRPVNLREYLRANRATRDGILVNKEQLKPEMYAGIRLRSLRIPGQEDKLEAGKQSEDEKRKKYFGTNQARPWNDPWKSVSELARLEKDRLEKEAKLGEDSPPKPLAKPRGTPAAEGWFRDPDTPVKVFLRKFRKLKQVENDAAGIGAEETHANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH55</accession>
    <name>A0A2T6ZH55_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH55"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="102" mass="12067" checksum="A6A21EC2957E27F7" modified="2018-07-18" version="1" fragment="single">MNELKRPRGKGKTRVDYSVRKKEKKRRRKPLVVAKFRYLFGELFFFFLCLSPSQVQVGSRGLVFRVDWTKKKRKKGPGHLWSRAEPTRVVVHPNTAQPDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHD6</accession>
    <name>A0A2T6ZHD6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1156352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000266">
        <property type="protein sequence ID" value="PUU74866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHD6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16506" checksum="63C8B42B7324173D" modified="2018-07-18" version="1">MADQPAPDFNILFLSMTNAVKKIQDATAELNAAAVQLNIAAVEMYKMKKLADEIKSIKEAMVKLAQNNDCQINRVETNDIARIHNSKTRLQLKPLAGPSGDPADNFPATHKQLLALNEEAVNNLAANLGLNPEGTFQEKRDALYAYVGVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHI9</accession>
    <name>A0A2T6ZHI9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_392862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000264">
        <property type="protein sequence ID" value="PUU74874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHI9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14752" checksum="8C9A18BED087A4F2" modified="2018-07-18" version="1">MFRSFRKASQPAPGEWSWENGDSVCIYPSSSYFLPFSLSCVTLFKFRLLFPFGVYPVSPFFFFFCSCEGWSLFLIFPFYFQVRFLTGPIGVMIHLGFFFRQFSNLVLCNLKNRPYIMLSCANRVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIG0</accession>
    <name>A0A2T6ZIG0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B9Z19DRAFT_1116512</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIG0"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="36"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="194"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="467"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="574"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="680"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1085"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PUU75271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1206" mass="136128" checksum="EF6ED68962B70690" modified="2018-07-18" version="1">MATTFKPDTSFNTLRREDLFRNPPKDKSAFPALLNAVRPHIESFNAITAEGGLLDLARQDIGVKCVFDGKGDGEGLGNKLSLRVDKIYVGKPKISERDKTTLRREIFPAECRERHITYRGKLSVKLGLKINDGPWVSQDREVGNIPIMVRSNRCHLENLSPHDLVERKEESEELGGYFIVNGIEKLIRMLIVQRRNHPMAIIRSSFAGRGKSYTNMGVQIRCVRPDQSSQTNVLHYLNDGNVTFRFSWRKNEYLVPVIMVMKALVETNDREIFDGLLTTKDMEDTFLTDRVELLLRTFKGYQLLTRKENLQHLGEKFRVVMGVSLDMSDVEVGKEFLRKIVLVHLEDPRDKYRLLLFMVRKLYALAEGTCQADNPDAIQHQEVLLGGFLYGMIIKERAEEYLESIVKEVRREVERGNVLDFNNKEHRTKMFQRTSEDIGKSLGYFISTGNLSSPSGLDLQQVSGFTVVAEKINFYRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHLAHKCRIITTPSDVSSMRKTFVSLGVTSPATSPLPHSATVCIQLDGCIVGWCSPKLAKVVADTLRFWKVEGSHDIPLDLEIGYVPISRGGQYPGIYLFSQQARMTRPVKYLPLDKEDLVGPFEQPYMSIAVTPPEITPRESTHVEFDPTNILSIIANMTPFSDFNQSPRNMYQCQMGKQAMGTPGTAMRYRSDNKMYRLQTGQTPIVRSPLHNEYGLDNFPNGMNAVVAVISYTGYDMDDAMILNKSAHERGFGHGTIYKTEKLGWTEERRSRARESKFLFGFANPDEISANIDELHEMDESTDEAKVFKRKAYQRIGIRQEWMRTVDMDGLPTIGQLVRDGDAVAAYHAIPKEGDRTRPENKVFIYKGSEDAYIDEVRLLGSEGGDNKPMQEISIKYRIPRAPNIGDKFSSRHGQKGVCSQKWPSVDMPFTESGMQPDIIINPHAFPSRMTIGMFVESLAGKSGALHGIAQDSTPFRFDEKNTAADYFGHQLKVAGYNYHGNEPMYSGITGEELHADIYIGVVYYQRLRHMVNDKYQVRTTGKISELTHQPIKGRKKGGGIRVGEMERDSLLAHGGAFLLQDRLLNCSDYTQTWVCRACGSFLSTSPSVRGSSFGSMVRCRRCAKPATGLEEEEMIWEDGLGGRFVGGKDTTVVAVPYVLKYLDVELAAMGIAMKFNISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIP9</accession>
    <name>A0A2T6ZIP9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCR4-Not complex component, Not1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1131435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIP9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIP9"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CDR ABC transporter" evidence="5">
        <location>
            <begin position="207"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="373" mass="42650" checksum="C9ED1A15AEFBCBDB" modified="2018-07-18" version="1">MLYEYRLIENQMKGYHERILETFAECFLTIQPVFFPMFSFHWMTLVSHRYFMPKLLRLKGEKGWPVFVNLLETLLVYVDVPLKERSIPPVVGLLYSGILRVLLVLHHDFLKFLAEWHFSICTPGARIPSPLLHPQGFILPGEKGWRRADWEYGCVFHAWSPTHTSQFLISLLVVFLITANMYSFRMVGVFSANLDVAIHITGVSIQALILGTRIVRGEDYIHTQFTYLWSHLWRNVGIIIAFWMFFAIMIAVDLRLRSRTAGVLEVIGGGPGHDGPTPPTTGNEPEADRAPKEFVVVVPYAGIPNLWRFVYWISPFKYLVSGFTGVLVHDVPVRCSKNELAKFNLPPNVANCAEYTADFVKRLGGYVEEENGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJZ8</accession>
    <name>A0A2T6ZJZ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJZ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJZ8"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="31775" checksum="91BBA450E5CC65FA" modified="2018-07-18" version="1">MELAVRQRQPKIPKELGCGIEGSIILQDALGRTFPVPFVVCATPEMFHGFLELSFRGLPGHEKVVSREYSISDEKSQKDITSTVWVENITPGRLISMSILFRHMDNAHRVTDFKSKCPSCKTPGAFGATGSSRGWIQCKFCQVWAQHSKECPVKTPVHILEPTYDKPLSPSETSPSLLPSDVSTISKELSSFRRVKFVEVSRVSYLSALRIAKELANDRKLCKELVWKLKNMGDARFVEAEFLDESIICECLRDGKRDHELAGRHSHLDRFLPTKGRISEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKC5</accession>
    <name>A0A2T6ZKC5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1102625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKC5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKC5"/>
    <dbReference type="OrthoDB" id="429671at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="309"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="709" mass="77183" checksum="69828AFF021EE16F" modified="2018-07-18" version="1">MNNYIAVPTVPSSTQLRGRRESASAYVPPPAVPMGFASQRPVMQVPSPPVVVTSYPTPPPPPIHHIPQAAPPPPPPPPPPPPPAPVQFSRPAYVELPWYSSPDASFPARRRRRPILKDVEPSIKNVTKVPDTPVDLQLQETPTIPILQPDLSELPTPETTQPSSEIGSGNPSTPTSTAPPSASTATIQKLVPALPLTPPAVPIIKSKAPKAPKPAEAKEAPIEPPLSAPSSETSAKTVPTLPAAVVPAVPKSWAELVKTTPSKDTEGTRVAVIQPNGTSNGKPGSIPQILNDFQIRPTEPFTIPFLEPRGLVNTGNMCFMNAVLQMLVFCGPFYHFLDRVGKEAAHSFKSETPLIDAMIMFMREFRVTPMTAKQGLEVLGEPFVPEFLYEVIRNTKSFAHMRRGHQQDAEEFLGFLLDGLHEEAVKMMTKCDGNGASSVSGDSSMDDTDESGWMEVGHKQKIATTRTTEISESPITKIFGGKLRSVLQVPGLKASVTLEPYTPLQLDIQAPEVRSVVDALKHLTTPEKIQGDFKSPKGPNVVAKKQVSIETLPPVLILHLKRFQYDNTGGTQKIWKKIGYPLELQIPPEAMSPTQRAGLSAKYRLIGVVYHHGKSASGGHYTVDVLRQDAKNWIRLDDTVIRRVRSEEVAVDVKDLGSHNTFDGEENEGWVNGWEEVTANGSGATNKGEGARYIGKDSKVAYILFYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL84</accession>
    <name>A0A2T6ZL84_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL84"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL84"/>
    <dbReference type="OrthoDB" id="5497177at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="439" mass="49087" checksum="7909664464C8DA69" modified="2018-07-18" version="1">MPRDAGGTADATGRLYRRFKCRARDICGKTLGVTEFVKLCHKLPPTASSHHHSAQISSDIGIDGPSVNQDATTCEQESTTFVSHSSTQPKDYTQPSVIPIPSSSGTSDWNMESELSDNDESTLRKRGMTHLTHEMEILRELLWKSIHDGESMKIKIGQLESKVEKLLRRNISGFSPTLSTIQSKVIQDNATSKMLINRHEISSKVEPILPQVHNRSIVTTALYVSGIPFMSIKDIKNILASAPINLQRRDICNLSWIDRRIVEILVNTTHAQKIKNRIGKYSEYIVKSDFDPLSPESFHWDGNIQPESQEAILKRNFVMRLSASVGSTTKTSTRQHIIAWANHRGIGPHLQQELNKQGIIFNAENETAFVNDALNDSPSVQSVSRSKQQSSIITTGASKFTKRKLNVTSDDSIQSSSVPQVQSKKRLRLRLTHGNRDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLB7</accession>
    <name>A0A2T6ZLB7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000196">
        <property type="protein sequence ID" value="PUU76214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLB7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="20088" checksum="BBB1B81A389EA280" modified="2018-07-18" version="1">MHRIPHTTNSEEWLSAITPGLTNQATNRLICAEADAKLIRPAPTCSPCDPEGEGTTAGTTSPPPLNTTKSGEGTLFLGPCQHSDWAPPRATITLPNTTSLSPEETGPVTLPTDKPEGKLSRGEVGTRATKGEEADTETERHTIRHIGAPCTQCWIPSYGPPKRTDTQNMRPYFTHTPAAPTLGHYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLS0</accession>
    <name>A0A2T6ZLS0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIM-domain binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLS0"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="627" mass="67821" checksum="DD3EB1D362E2E8CF" modified="2018-07-18" version="1">MATTTAYSHPNQLQQHPGVQQAPQQHIQGHPGQPTHAAMQHLHPQQAQAQAAAYQQQQLMLAGMQGMQGMHPQMQMLRRQQQQQQAHLMNGMGAPGGMVFQNNGGPQIRASMPNGMYQGGPGGIPGANMGGYGAGGPHMRGNVNLPPHMQQQLQAHQQQQQHMAAAQQMALASQANAANAQTPMAMPPQPPMAMQAQHALAQARQPQKTLLGHSVLGLYRFSGHLSAFDASKEPNDINFWRKFVTEFYSPSGVMRQLLWHSSNRETKQFEVTTQVLARYYFILFGSGVQNIQIVLENVREKELANQCHAVECPKTSFIYWFENGFHLVARGSLRAIFNAASKMEELDFRVEQHSEYVPRNFGQDSPDVMKSSPGSKSLGKRPSQQGHPSENIVNCYGVPDAVLQCLEISETMSQMRDLFSFSQSNPALVPRQALQTFVSQHQQQQHAQQHLANQHAQQQQQAHAAVMAATAQGLQAPQGHPGGHAGGPGMLQHPGQHQGMPGGVSVGMNSPSADGMRMGVPPSPHMGGGGGPGTTPSPAQNHIQAPGLVQQHSQQAHPTSNPSSQTSTTVVSANTSPNTNKRRRASTTSNVKNEGDDENGVNGAQNNKIKQSPRVGGNKRVKGNNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLV9</accession>
    <name>A0A2T6ZLV9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLV9"/>
    <dbReference type="OrthoDB" id="5462016at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="369" mass="41911" checksum="02457892E500B155" modified="2018-07-18" version="1">MNIPHRNNTLYKLDVSFPEVHGNRLEFTDDAGETTQSPPRAASFPSPSQNIRLVPASEILPSPAPPATSKVKGSVQFANEIKVDYFFYPNQPVDQPIRMRREIYDDDQGVLLYYLEICEEGLEKIWNIPHRTIRCQINGKKGVIARLNKDKQRHQELELAGYGHSGIVEVEGKGIGRATPINHKMKDKVARLKEELKEEQLLTPAELEIARKTAENTKMNTGTFKTFEEMMELTTPVMRNKRRHFTPSSIIPPPHYTLRNASDKNATEDQRKRARVSETNGKMPGDPLRIPDEDAQRTSTKPNTTEKKRTPKPTERGIGAEKPLQWDKYLEATGKKSTAAPIKRRVLRGSCLKILHPFFSAKKSKKAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM56</accession>
    <name>A0A2T6ZM56_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000183">
        <property type="protein sequence ID" value="PUU76563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM56"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM56"/>
    <dbReference type="OrthoDB" id="5397805at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="326" mass="36475" checksum="B4C55B3272876EF7" modified="2018-07-18" version="1">MPPRQDKTRAELERLKLMELQELSEKNLVESSDTGATMIERLMACSQSESMAPSGKGKEPATPESLDDTCGAIEVTTSGIRDQTSMIEEAHKALEDVPEEEELDVEYDPLTAGNRGGISWAAFPRRLEMFEAKLASIQMELDSTKMVVDEHGKRLSSLDTRIGDLSISADAYKNIRHNFIDMYVRSTTSGMATRTRKQTQEGKGAVHGGDAHVDANLYRDGQERNDFQYLKSSHMETINVLNIHAGIKADQGESMNPRFYGLFDDFINAWENFGYAINYLEESAKDSHAAAVNKAYWALHEFLENEEWRKGEEAPKRGRAAGEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMF2</accession>
    <name>A0A2T6ZMF2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1087834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000180">
        <property type="protein sequence ID" value="PUU76670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMF2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="75" mass="8197" checksum="F43EA5323C4E36BC" modified="2018-07-18" version="1">MVVLAIPGSIPIGSHGLPVSPEDQPLGTLHRKMLDRPQEHAGRFVCRVRINAYGTLVDLPSQSQTHCWTISNHGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMI0</accession>
    <name>A0A2T6ZMI0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_228578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMI0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMI0"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="26550" checksum="D27BBD46D01BE295" modified="2018-07-18" version="1">MGVEEQLQEIEVLQSIYPDELTQISDTSYTIRLVLEPPSIPGQDHEPPILILHVEYPPTYPDVPPTLDLTLDANSPPSSLSFPDDKNTLLSALSPTIEENLSMEMIFTLTTTLKESAEEMLNARAQEKENKREEEIRKEEEKEMEKFRGTLVTRERFIEWRDKFFAEMEENKRREKEEDEEKNKKGGSGGSAVKEKRMTGRELYEKGLVGNADDGDTEDGEVVDLSQLKVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN28</accession>
    <name>A0A2T6ZN28_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1087384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN28"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN28"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="410" mass="45627" checksum="517D8D539BF2ED84" modified="2018-07-18" version="1">MPVIIEPSPELVGRNTDPTVHTSEGLLKHASRAWSPAYEKINWRTGKTEQPEKRRIVHSSFHELNANTSPIIPYGNGLVNGIIRAFQQDLHLVLRPDDIWLSILTQFSMFVNGNSEHLRTQFVAHQGKKELAIDIRPQPIGDIDMGRFAQAMTHLIQENVVDPQLRELIMPNFSTTTDDDKSVASIVMMGTLQSYFKYSLMAGCGFPSVTLQGEKSDWEEILLKVQQLSKYGPLASEWTRLLIPVIQYMIASFTQPTSPHVKSFWLRACHAVGNDGYGSARTLSGWITAFCFFSEKGQRTSEYSDEQMSKWDGVSIAERQRLVLGDIAYPVIRPSSIPKGVVSVPVTVKDYATGLEHKTTMVAGSVGMMLSAAESGGDLNKVQPKSGWWILEDSVKPMDGFTRLPAAAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN33</accession>
    <name>A0A2T6ZN33_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN33"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN33"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="301" mass="33922" checksum="1EFCAA8117EA20B8" modified="2018-07-18" version="1">MDFDSAGYRELQAACKASGIRAIGSRQDFIERLKSYKSEKDTEFQPSRVDRAENRDQEAIPELATSSLAPVGQAWDPAGETSDQVVRRRRGLCSEDIPALMEAIEKERTALAEAIESTNKGFAKLRLELRSVDKFVSSLTASLHPYHQTRNRFLSTFKKDKLGTATGDDWKIIAQGSFKPEAGDAATDALLYEGITGRRDFTTFQKLYGLHPDMVRKISHPETLAALNMHARVLASHKRTGSPRFYNLFNEFIRLFTESGMGYDVSYLVGDRTEVTNAYLAFFTCVKTEVTWVESGYHRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN73</accession>
    <name>A0A2T6ZN73_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hepatocellular carcinoma-associated antigen 59-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1051191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TLS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN73"/>
    <dbReference type="OrthoDB" id="5627at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010756">
        <property type="entry name" value="Tls1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486:SF2">
        <property type="entry name" value="SPLICING FACTOR C9ORF78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13486">
        <property type="entry name" value="TELOMERE LENGTH AND SILENCING PROTEIN 1 TLS1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07052">
        <property type="entry name" value="Hep_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="403" mass="43358" checksum="FE2B7485E07E3680" modified="2018-07-18" version="1">MEVEAASATASQIASALPATTEFPSFTSTTNSKSRKFRRRPVEDDDGPAATAAPTTAAAAAPSQPSQTTTTLTIPPAPPPRSPNAESSEPTPSLTEILRLRKKIARTSALRGLEVSAPKHVLQTPAQDSGANDNAAAKAAVSEAEAEAVVNRFTHQTGQILDVDKHMMAYIESEMSKRRGEQGGDGSGAGGGNAGARGAGWIGSGGGRTDQENTKSAYWTPVVPEGRGATLGKLHEVDLGEEAKKHNIARTKEATRRLQGGEEEIEDDPSTASNTSTANNNVPNRKKMKNRRRRNSQDVQRDKLVEEVLKESRLEMYTDPDPTEDQRESEGAADDRIAEKFRREFLDALMTRRRRRGGDGKKKRDENKKPRGPKLGGSRQARAAMRESQQNSAVGSGAGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP71</accession>
    <name>A0A2T6ZP71_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1101944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP71"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP71"/>
    <dbReference type="OrthoDB" id="5385482at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="56361" checksum="E7C8FD8B82E1DDFD" modified="2018-07-18" version="1">MAASSSSGIVERQYNYGGLIVRTFVHSAKSSPPPALGAEDSQSSPLNSSTPNNQVTSPVKRGRGRPRKNPKPNSVADDDDAVSDKSSQPASSSQQKPPKKKRKQLAGVTSGNSRVPAYVSLLTEEEMTAVRKRNRRGKQWIPGEKTVMNELARLGRSVPDLTETHQLQNGEDGVGDDEDPEAEFGLAEGIEPADDDVIDCDPFTGLDDMRLDSTDNAGMTGGVGSSSASDWMRANNEQTQFQQQTESNGESSFDYYMCPPNGASTLEPPSAALDKDSSFAEQLNSVVPELSEPILRPSDAVTTLSHPTPPPSSLSPQNPPPKRPSAPPPPAIPVDTAAALGAKLVELIAASQTAFIPTLVHCSFTLPLPEGEFTQKQYATDLVSAISDVDRYVYVTKNSTWNSTNSGSRGAIFVCNMSLESLKKRKSGTGEDQKKVSMARTRYPCEGCITIRFLAKKNVISVLYKHHAIHRSPHDKIEDSDTAPENNTTTNTIGSTKDALTPLEKPPAEEIVVPALAQIPSIAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP72</accession>
    <name>A0A2T6ZP72_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1146401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP72"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP72"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="211" mass="23437" checksum="84CEFD60CFFD746D" modified="2018-07-18" version="1" fragment="single">ILIDANNDSRYVAFGHARNTIRRLIKGLKAAGVERGDCVLIHSFNDIYYPLIGLSIIDAGGVFSGSNLSYTSRELIHHIATSQTRILISEPEMLVNARAAIDEMPEGSVKAVYVFNPREGQSVPARERSWEELLNSGEEWEDWVRFDDKEMAENTVACRLFSSGTSGLPKGVEITHYGLVAQHKLAHETEKGLENVGSPLHLQLLHSRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPY2</accession>
    <name>A0A2T6ZPY2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_889812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPY2"/>
    <dbReference type="OrthoDB" id="10289350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="51" mass="5740" checksum="DA1D8A1F77F43EFC" modified="2018-07-18" version="1" fragment="single">KKNPTVAKPPNFPIRQDITKTHSQTPQAQRNYPADQCGSNRHNLISTSPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ85</accession>
    <name>A0A2T6ZQ85_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1085899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ85"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="153" mass="16978" checksum="DC2209057EFECFDC" modified="2018-07-18" version="1">MFLLLRQMDLDLSWPSSRHISAEAKFSGRLPRTCFPAPPVASCSAGGNFLRCRVCESGFCGKYTIPPLPRSVVGALDHGLAGVALLPWNKYMAICLHPLSGDFIWAVSLRTYFIVPNRLSGRLVIFRTNACYPLQECTLPMLIPRGLVVRARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR34</accession>
    <name>A0A2T6ZR34_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_127193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR34"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR34"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="11">
        <location>
            <begin position="97"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="545" mass="58599" checksum="78363CFA6845CF76" modified="2018-07-18" version="1">MSAILSADDLNDFISPGVACIKPIETLPAAPDQLPSNSYEVVREDKAPPTDLPPAQISLTDCLACSGCVTSAEAVLVSLQSHNEVLANLNAHPEKLFIALMSPQSKASLATAYGVSADVAGHMIERLLCSPEGICREGRGFDFVLDTNATREVAVRFAAEEVVTAMHGGRDGVHGRKMPILASACPGFVCYLESTQPALIPHLSRLKSPQAILGTAVKSLLYKDVKDGVNGIYVVGVMPCFDKKLEGARGELTSGAWMEGNEEAVRDVDCVITTRELISLAQARGVDFATLPQSTPLLSSSNTTSTLLQTLKSPTKSSTTKANPTPGTSDGYLTHIANHILTLYPTSTLRIEPGRNSDTIDYVISTPEKTIARLSRCYGFRNIQNLVRRLKPAKTRALPRFGKAITLQRKPLAAAAVRQAGGKSDAEYTYVEVMACPGGCTNGGGQVRYDDEIIASGLGAGTQKEWLGKVDEAYYSSTEDEENGEEGGVPQEEWVERFVEEWENRTGISKDKLLFTGYRKVENDLGGRLKEVSVVELASKDGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRA1</accession>
    <name>A0A2T6ZRA1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_984500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000131">
        <property type="protein sequence ID" value="PUU78020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRA1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRA1"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="942" mass="104841" checksum="F315EA014CEC1FD8" modified="2018-07-18" version="1">MTKNWDSVKVTLHELYMERNLKLDDMIRIMKESYDFSASPRGYKKKFKQWGWLKNAPIQGESLLDELSRHSPKEFTSVADGGKTFELVQAIDGSTPVYHSNKYMPIRAAPQAPIQIDTAGGRETPANTFPLGSSTSPRWRAREHGGRPSTHPYSRPRQNSQSQSGHQRGPGSLESISVSLTGMEIDPAATPATTPTVIPTPPLQSPSYSHYISSPSPAPQQTEQTKISSIQLSNFQAHVINPSLADFPTYRLNPPRLKTDFIDEISNKVLQTAQNYQQKNDFYSAAVVLQLGLNKIALMTVDPSELFSPEPSHLSLAQVMGGFVENVSWENVYLFRNGFMLALLLSTSYEKIGDMHLAVYVLEQTLKAVLMSRVGILTAGEDEEETLEGMFEFADEDCSRILRSIIRIRELKEEGDTSEHKTIMAGTFGILERFLADWEGAFGVLGVLSLGEFLDGLLSFAKRHKMEAAAVGQLKQILSKAEKVLVSGGGPMSVAGDNENFRWTSARYFSRISRKLSALYELSGQALAGIHLLKRAARIVGGNHNGHPSRKEKREMFEVTTAQTQLQEKSGLWDAADKAWKQLRGVLDEREDFELTLKVDVAIAELLARNGRQGEVLVFLEHRINECLRHKMLEQQLSSARAALDDAEPIFRAILSLAKLRLSGTVTVTVTPPALQAYFRWLLGVRGLDGSEKIAIAHKTLELLTELQPNHPNLACAGLIIYDEFLPGFIDLCSVVTPSLSQNAPYPTAILRFLSLIYNTAGKDDQPRPTISHIVTGLSLLYETHLSRAQTSTEILLYVHSLTSVLCSSSKGRLCEECKVDEFTTAVALAEHYERQGAAQDGARVIAQIIDEAEPEFLIPATKGWVGFSWLKVLMRIAKFYIRQGQSVAAVDILERVHRASVELGDWDRRDPTRKLEQFGVFDESRRLLIGFEPASVLCRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRA7</accession>
    <name>A0A2T6ZRA7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_984595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000132">
        <property type="protein sequence ID" value="PUU78006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRA7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="7774" checksum="CCCDF2774F671333" modified="2018-07-18" version="1" fragment="single">VQVYRDGRISREYMVSPRRICVSTPSLGGRGSSTAHLWHVYHASSRTSLAGMRETPGMDVLDRGGKTVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRP9</accession>
    <name>A0A2T6ZRP9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_919834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRP9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRP9"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="544" mass="58871" checksum="968F9065FB5A9A8C" modified="2018-07-18" version="1" fragment="single">MTWIDWTNRRVANSPFGRYFRLEHSGSKKERKGSRFFTEIRAGLATFFAMAFVNANITSQSGGTCVCTPTPDDPVCDKNEEYMLCVGIIQRDLVTATAAIAALTSFFMGLGANIPIACAPGMGLNAYFAYQVVGYHGSGPVPYRLAVTAVFVEGFIFVGLSILGLRQWLARAIPASIKLATGAGIGLYLALIGLTYSAGIGAITGAVSTPLDLAGCRPEFRDEITGVCKGSQMRNPTLWIGIFCGGIVTALLMMYRVKGAIIAGIALVSIISWPRPTEVTYFPYTSEGNQRFDFFKNVVAFHKIQKVLVAQEWDISGAGGQFGLALITFLYVDILDCTGTLYSMARFAGFIDERTQDFEGSAMAYIVDALGISIGSLFGSPPVTAYIESGAGISEGGITGITAMVTGVCFFISVFFAPIFASIPPWATGSTLIIVGSMMMKAAADINWSYPGDGIPAFVTIMVMPFTYSIAYGLIAGIITYIILNTAAWLIETVSGGRIVPYGKELKDHWTWRIPGGFFPKWVVRIAHGDRKFWKREEYHDGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRR8</accession>
    <name>A0A2T6ZRR8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NMDA receptor-regulated protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1084726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRR8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRR8"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1010:FF:000002">
        <property type="entry name" value="N-terminal acetyltransferase catalytic subunit (NAT1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="583"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="848" mass="96904" checksum="A375566A1EEEE4DE" modified="2018-07-18" version="1">MPQAPLASKDGSLFRQVLKCYETKQYKKGLKAAEQILRKNPKHGETLAMKGLITNSLGRTEEAFAIAKEALRQDMKSHVCWHVYGLLYRSEKNFEESIKAYKMALRFEPESQQILRDLALLQVQMRDYPGYVESRGKILQGRPQLRQNWTGLAVAHHLSGSYAEAENVLKKYEETLKNPPSKGDIEHSEACLYRNVVIAESGDIARALEHLESVAKVSLDKISVMEYRADYLLRLDRKEEAEKAYRALLNRNSEKRQYYRGLERSMGIDPEDRKALKAIYDEFTEKNPRSDAPRRIPLDFLKGEDFKQAASVYLQKLLKKGVPSTFANIKALYADAAKREMILELVEGCLASMGTEEEAPTNGETNGDKSKPSEFKLWTLYFLTQHYDHHRTRDTAKASEYLNQALELSPSTVELHMTQARIYKHSGDFQKAMEKMNQARELDTKDRYINTKCAKYQLRNDRNEDALKTMSLFTRNDAHGGPLGDLLEMQCVWFITEDGESYLRQGNLGLALKRFHAILKIFDDWTEDQFDFHSFSLRKGQIRSYVTMLRWEDTLRSHPFFVRAALGAIRVYIMLHDRPHLAHSSLSNGNREGTDFEGMSPADRKKALKKAKREQQKAQEKAAELAAKAKEDKARNAQVSNADGEMKKEDTDPLGNALAQTKEPLEVAMRFLAPLLELSPKRIEVQCAGFDVYLRRKKWLLALKCLIAARELEKENPVVHEQTIRFRRAVDSLADEDIKEPSREVLTAELESILPKETDLKSYNEGFLNSHKDSPKHVHGALRARHLLNPEDANIADELANTLSLENLTLKEAIEGQTLLTDLKAENKDYNQKASERFPDAAAFQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS04</accession>
    <name>A0A2T6ZS04_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS04"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="639" mass="70013" checksum="C525BE2FF527F596" modified="2018-07-18" version="1">MPVTRSKKRRPSDVDLGGRGSPYPRKKNRQGTNPPPKPSRLLGGNTALGFREPRGYNRSGSFYDRRSPQRGLDDTYRPRPTWGSYGLDSSRFEDSRAAASQPVTSSLEGSVRPRGRSPIRRYHQLGASDERGVGRATRKPLPDHRDHNGIPNDARSWSPRPRDRTDGPAGPYRFRDGNSRSPPHAGKGIETEAPNGPPFCNTRARNPSQSSLTHNRDFLDLARGLSGFSLTKESPKLLPESHDLGQPTKELSSLGENSNVTNLPERSLTHDRDFLDLARGLSRFSLTKDSFKLPESHDLDQPTKELSLLGENNNVTSSAGSQPDINVPHLRGRESPPEDTSHSCDSRSPSPHRLCSQREGGSSRLEESRVLPVLFYESPVLKLKHDFFLPESASADRELYVKAGTPGELCALKSDSAPSPGPSDSTWRTANFTPSNWELVHGRARQAKNRASAALLPDNVPLFGPKIRTSRKGKFRGSLEEYDQMLLDKEKTEHDDDPTFPTGSWEDDDSTSSSSEGEDYDITSLKNTLVFEEGLPRSKSQWGTPPGGETQTQSKSGPLAEDTHCASGVPDGGACGIEPTKKLAMARGKQLRPELVQAIALLRASRSQSVHPERECGGGQLPLASEGPPDSTRYCSGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSR8</accession>
    <name>A0A2T6ZSR8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiotic nuclear division protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_982990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSR8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSR8"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19361" checksum="482E44738AA0D36D" modified="2018-07-18" version="1">MPPKSLPPAKLAQVLAHIQALNTTHTLKDLEKIIPPATGVSGMLVKDYLTALVDEGLLRVEKIGSGNWYWAFRSEETNTKRRILKNCLDEKDKLRSAISEAKRAIREIGAEEGEGSEELVKRVQELKAVKAGMVAEIRGYEEGNVDGLKREIEEMRDRINLTIGIAYPAATPVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTG9</accession>
    <name>A0A2T6ZTG9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTG9"/>
    <dbReference type="OrthoDB" id="5483215at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="19486" checksum="C293971B3D35FF49" modified="2018-07-18" version="1">MFRFTTRLPLKGQIPIARYLTITTPKPGIPNNSQPSGELSSHRELSSKDKVPVSVHQAASLSNAGSDKINFEQTDDSLEDRVYRLEDKASEFAQALGRIDGNIGTIKWQNGILLTAVCGTGGALLYWFIKGELTKSPKPGDLEKMVKKAVKHQRLKIAAEQSQTAVKVPKAQMVAKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU17</accession>
    <name>A0A2T6ZU17_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_22590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU17"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU17"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="202"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="364"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="493"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="602" mass="66085" checksum="FFB8AD5445488F5E" modified="2018-07-18" version="1">MSTTPPPPLSPSSHPSPSISTSSSNEDQLPTPRASTHQTTITLTEDYFAPPLPPRPSLEVTTSNTLLSIQSATSSGASTPGLQAKPTTAISLPEGVHAQQQDAVICGNGSITGAPSFSDSISVKSLVPTLSAGDNDVESMLGEILEEEEEGFLKARRDIMNIGGGGVGFEEVEFEDEGWDESSDEEGLGEEELLARWRAKRKHFFILSSAGKPIYSRHGDESVLSGYMGVIQAIISFFQDDNDTLKSFSAGRHRFAIAASGPLYLVAISSIGESDSQLRAQLDALYTQVLSTLTLSQLNRIFAQRGNFDLRRLLGGTEVFLDGLSDAMTLGSPQVLLSALECVKMRKSHREKINSILLKHRSPSLLYGLVIADGRMVSVLRPKRHSLHPPDLQLLFSMLFNSTTFRDGGEHWTPICLPKFNSKGFLHAYIHFFRKEVAVVLISADKDAFFEMREMKEVVVEQLEKAGSIKIIEEAVSNGRYTTTDVLSPGTAIRHFLYRSKNNVQFTMPSFEPHFYTVIARRRLMNLYQRLHAAVHAKNALLKVHHCVRNSSVSLSWVTPTFELYCVAVAGANRAALASSASAIAAWVKREEERLFIGGVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU39</accession>
    <name>A0A2T6ZU39_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_980869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU79000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU39"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="429"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="780" mass="84518" checksum="86B4A8DE44F21E6E" modified="2018-07-18" version="1">MMTSAAPAQAVHAVQGPALTDHSHCPPATTATSTQNSNRRNCSRSANRRRNRLSTPVISSLQSSTYSSTESIARRIQRTHSAVAKRLFASAVSSPSTFSSRKSSPQPPTSPPMSTGRERAIGGGNSGIPSHHVRNSSAPVRPASATLAPRNCEGGHSNGLRDVNGDIAPLVSEKPQASTSGGAVTMTIQLAEPMLFLQGFDQSDHSNRAPAMLRGSLLLRISKPTKIKAVSLTFRGRARTEWPEGIPPKKSEYFEEKEIMQHTWPFFNAQFATAELGHCADSCRLYKSSSDNTSSITSAIGHLARSASPIGISPALGRSSTDRRLSLQLAQSRSFSKGESPNGVSVAQRGYRIFQPGDYVYNFELPIESCLPETIDVDLGTVKYELEGTIERPGAFRPNLVGRKDVIMIRCPAETSLECSEPIAISRTWEDQLHYDIVISGKSFPLGSAIPIAFKLTPLAKVRCHRIKIFITENIGYSCRNKKVNRLDPARKVQLFEKRADGPPISTFAGSSGRILAGGGFSEEQVAGGRNLDGGNGSDNLLGDLHGQDNIGPTEMELSVQLPGCNAKEKDRIHFDTTYQNIQIVMRLSKADPNDPGKRRHFEISIDSPLHILSCHATSANTALPAYNSLTPGVAPPGTHCSCPPLTRRNSPRDGAPTLNVNTQVGHFSSGQPEPPNEVARPLHLIRYPSHNPPPFDYDVAPPPLITPPPKYESVVLGEGLADYFQRLADETVGDDDTDDELVNGDHRRLMPPLTPGGRIARSMDERRTWMPLGISGQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUC6</accession>
    <name>A0A2T6ZUC6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1082684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUC6"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="206"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="424" mass="47005" checksum="FA2545529E1EB120" modified="2018-07-18" version="1">MFLTLHKPRILLVLRRITVAGARGTICKLPVSSPPSSSLSSSLLPPLPGSELGVRRIATSQWMFARARSPKTYPESIREDPPLREEHGDGGRNEGEMQAEFEGPGPDDPEPGRPVILFFLSLTLPVFILSNISLLTPFLVSARDLESGSIPTSTSTSSPTKEQLNAYVRAHRPDLLRLQRISQATWANTTLTPIRFFPQSAEPKPWHTIVTHAFNHAGVMHFFFCFMGLKAFVPSLSFAYGDRRTAATFLMGSAMTGAAITAWERWMNPWSKVSGQDLHVALHHHRFPASAMATIDEDKKKHLERKLRDAISANLGSSAGIFTLGTITAIICPGMELNLLFIPYGFRIRTLMAALAAFDFGGAFIWDYGLGIGHKGHLVGYASGILLYTLWLRRVPFAFTLRTNELLRRAAMQRSSRSPPYPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUJ1</accession>
    <name>A0A2T6ZUJ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal L29 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1082439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUJ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUJ1"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="123" mass="14243" checksum="2D899D0E93BF6644" modified="2018-07-18" version="1">MPGVKTSTLWTKSKTDLNKQLEELKQELANLRVQKIAGGASSKLTKIHDVRKSIARVLTVINATQRQQLRIFYKGKKYLPLDLRPKQTRAIRRRLTKHEGGLKTLKQQKKLTHFPKRKYAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUS9</accession>
    <name>A0A2T6ZUS9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1114587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUS9"/>
    <dbReference type="OrthoDB" id="5311064at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56547" checksum="84FBB6E43F7C3CC1" modified="2018-07-18" version="1">MVRDHTERAKRRVGNRAIALIDHLLEPTEDAEGSSSRASLVRELIVHNDKPRSGQGIFTEQDYTNEIQDVFSAIVRLLGKMATLWVLRWHSYDTPTREIIDTLARKCPNLRETHISGPIKDFPWFQTVSVSSPPGLFSPILHTLKSFRCSLPEGSIDILHHILENCKSLEALGIAFAPTDSLNAITPRGKPWNLRLKSLELATVGLLTGGADATARFCGSFDLGGLESLRLDRCNDIPTLLEALSVTSGIERLRHLSIWTLAGQNEMSQITSFIGQLGQLHPTGGLESLELADLGSKIDFEAVGRNKRLVVLRVTEWDAFISPLIPNHTGISSDQILGPTRGRLLNTRDIEMLGRNCEGISELWVDVARRTKLDEAIISSFGSLPALKKLGLCFQPPWKPLESLGIREQKLLETEEDVMRLDQQAILRIAQLVHEHGATNLREIEVQYGCRSKPGEPPQRPCSTSDGGGRTVWRIQKKEDDLQVGLFKADPLVNRYGVPISYVFEGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVY1</accession>
    <name>A0A2T6ZVY1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA polymerase epsilon catalytic subunit</fullName>
            <ecNumber evidence="17">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B9Z19DRAFT_1081154</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA polymerase II participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="17"/>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZVY1"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000002">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000005">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1600.10:FF:000006">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 17" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="19">
        <location>
            <begin position="1522"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU365029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PUU79640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2229" mass="254339" checksum="6328E2A1D8C1544E" modified="2018-07-18" version="1">MYSSRGGGSARFKRGGYRRGGNSGGGRFQKTKTITASSLLATDGTSGEEKFESLRLANDIDERMGFPRFEAGPKKVGWLVNMKSTVLEDNQVTGGKAGVDFYFLDDYGGSFKATLLYDPYFLIAAKRGNEPEVEEWLRRKFEGIIKKTSRLTKEDLRMPNHLLGYRRTFIKLEFVNVTDLLAARKVLMPIAEKNRKNVNAMDAYAEVASASAGFDFIDEGNDVRRSTNIVEACDFIIDIREYDVPYHVRVAIDQEIRIGKWYTVEAKHGIVSFTCIEDRLKQAEPVVLAWDIETTKLPLKFPDASIDQIMMISYMIEGSGFLITNREIVSQDIEDFEYTPRPEYEGHFMVFNEPDEKAVLERFFDHIKEAKPTVMVTYNGDFFDWPFVETRASQLGIDMYREIGFRKNSEDIYYSNYSAHMDAFAWVKRDSYLPQGSQGLKAVTTAKLGYDPDELDPELMTKYAMEKPQVLAEYSVSDAVATYYLYMKYVHPFVFALCTIIPLGPDDVLRKGTGTLCEMLLMVQAYRKEIVLPNKHKQAEEAFFDGHLLGSETYVGGHVESIEAGVFRSDIPANFVIDTKAIDQLIEDLDSALQFSIVVEGGKKMEDVTNYDGVKEQIRTKLQQLKDIPTRNERPSIYHLDVASMYPNIMTTNRLQPDSMISESDCAACDFNRPGKTCDRRLPWSWRGEYLPTKRDEYNMIRRALENEKFPPKHPKSPPRTWDDLASEEQASAVRKRLTEYSKKVYHRIHETKTIEKEAIICQRENPFYVDTVKNFRDRRYDFKGKQKLWKRKADDLKASGATAAEIDEANKMTVLFDSMQLAHKVILNSFYGYVMRKGSRWYSMEMAGVTCLTGAHIIQMAKEIVERIGRPLELDTDGIWCILPGTFPENFAFTLEGGKKLPISYPCVMLNHLVHAKFTNDQYSELVDPVTHRYKTHSENTIFFEVDGPYRAMILPTSKEEDKNLKKRYAVFNHDGSLAELKGFEVKRRGELKLIKIFQSQIFKFFLEGTSLEECYGAVAKTANRWLDVLHLKGRTLADEELIDLICENRSMSKTLAEYGSQKSTSITTAKRLAEFLGEQMVKDKGLNCKYIISAKPRGAPVTERALPVAIFSAEESVRRHFLRKWLHEEPSDFDPRGIIDWNYYLERLGSVIQKLITIPAALQKVRNPVPRVPHPDWLQKRINTKDDRFKQKKMTDMFQKRTELEIVPPGMSTHLDDMEDFGGTTTMPINRPILGTARRLGKRKAPDTPGPVGGDPFASLPAVMPSMTGDYKGWLQYQKKKWKIQKHARTRRRQLFGDRSSLQTDSIGGFFRNQTEFMLSNTWEILQLRPTDMPGEVRAFVLVGRKIITLKIKVPRQIFINFKNEELPDVSVKGCIVERVNHTLPNGHPSGNLFKLVVPEDTYISEQKAFSIIFSHASVEGVYETQVPMSVRVLLELGNSCTFDESQRGVLGKGLDQGFDLSSLKSKETKSPYLHIGSMDYLFLYHVVAGDRQVFGLFPPGGEAYVVVYNTTREAQGLPNMDKIYAEQFTRKMEAANAPGNSMIEYPATLHFQTTYVNTKKKLEKELTNLLKKIRSEESKPTTLVIQSPQHKTLVDTVPILNEFPILTLRSDSSDSNLPPLGWQKFVAKRIVTHYLALGAWILHLVELARYGGVPLCNLEKDDPTFLIDIDYARRLQRNNVVLWWSPSPKPDHGGHEKDDILGPMETVDMPVINNPGSYSSVCIEIEVRNLAINTILTSSLINELEGSDSIAMNPAAPQGDDPADGTNIIFANNAFATAGVAVLREMVKAWSALATQGQPVAEIMVEHLVRWVESPDSFLYDRALHYYVQTMSKKAFLQLLTDFRRVGSHVVFANANKLLIQTTKVDVGNAYAYSEYIIKAIRAKPLFNFLDLKINEYWDYLVWYDEMNHGGKACEKVVEAENQELKIIMHWQFAKFLPQALQTIFNDWVIEFVEIMHTQKNPPASESNISTPRPTQIFFKMSEDPGDKIILGSEFKKPLRKQIGQLIRRQQESMIHPEINVDFEFPSLPGAYREMKNPVLQLVRSLTAVFGLAKEINIEARTLRKELLAMLDIKEFSKEGTFENPSETLKFSQVICKNCALPRDMDLCKDEDLMPEVTADGQLRERAWKCKFDFCGSEFDRLAFEEKMISQLHQFVAAHNVQDLKCGKCQTLKVNEFMEHCSCSGPWVLTVEREALIKRLHVYKSVAEHYSFRMLEGVVGDILASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW21</accession>
    <name>A0A2T6ZW21_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1046399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW21"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW21"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015581791" evidence="2">
        <location>
            <begin position="22"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="453" mass="45657" checksum="2DE94BF761814DDD" modified="2018-07-18" version="1">MKFSTSAFLIFLLASSEVVVAAPRRGRRGRGKGRGVGGPNGNGTNISTTITGKDGKPTPTVTDVFNLVSTTMTLPNGKVTETVIPDEDTLTTLTDVNGSVTTSTLPEETGVDGDDEDVSPDEEETPATPTATDITPAAETNSASGRGGNNSGPTTTKKANEPSSTSKKGGNTGATSKAASTTASSSASASPTNKGNNGGNNNGGNSNGGNNGGNNNAGNLTLDPKNVQSASTKTGQEAGDDPNQAESLTDPANFINFCKGKTLTNGLQVKSGSCNGIVMGDIPSTSNMVSTIITSPTPGQNIQANTEFTVKVTTNNLVAGSFTNPANTYYAAPQQLKGGKVVGHTHITIQKLDALNTKQAPAADVFEFFKGINDPGDGKGNLEAVVTDGLPAGIYRVCTLSSASNHQPVIMPIAQRGAQDDCTKFTVGGNGGNNNGGNNGGNNGGNNGGNNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWF0</accession>
    <name>A0A2T6ZWF0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphodiesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1063974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="3">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWF0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWF0"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="5">
        <location>
            <begin position="268"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="647"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="747"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="849" mass="93502" checksum="2ED44A05157CC717" modified="2018-07-18" version="1">MMMHQADYNVVYVDRRARRDRVQHQDDLLPSPISSGPESSDGNDEAQNENEEVVSNHTSPSPSPRFTLIQRMERENKRGENNSDGDVFKIVTICTTGTSCVSVLSDVDRNDPTPTLVLLDIPWQPQLEEDIVGHEGRHDSGIAADMLYGLPLLKFICNEVDALRMSSLVVPVAFLTNRELAATNGASPSQTYWSSTDREQCCEERELQCIDNGALDVLVSPIPKEKAKVMYIHCYRARKNVQKSRKVSWVGIDEQKPVREASDYAYLREKMVSELMTDICKPKRTKLFSRGSHIRISSTSVEKIKRAIGSWSFSAHDFSDEELVHCAKLMLEHALEMPEVEAYRISSERIVDFLTASRAAYNPKVPYHNFRHVVDVLQAVFYFLLQLRVLPPYISDEPMEMKPPPARTLSNLLTPLDALTLLVVAIGHDVGHPGVNNAFLITLKAPLAQVYNDRSVLESFHCAAFSQVLRRYWPKTVELRKSMIDMILATDMGLHFDYMGRLDEMKEKVLKDGGMDSLGDKAVSDYRTLVCALLIKCADISNVARTHECSSRWAKILIEEFARQATMESDLGIPSSLVAPPVTGSVLALAKSQVGFMTLFALPLFVSLSEVLPGMQFSVDVLTANKAMWQAEIEKITSASDEIVGGVSGSSNGSASGSVSASAGNRQDGEDLGDGRLGGSHGTHVLGPVVMESSTTFQSPGNSGGGGNEARLNGNSHQSSLGSSRIDSPPRSVLALDPGVQASAEQPTVTFVVTQPKTLSPDPLLDEKRPTHQYSSEHLGAQELPEQDTPNRPRSSPPDLGDHSSEHSCSKGCCGPTTVVSTSTIQRRPSSFFKRVKLWKSWRKETSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWL7</accession>
    <name>A0A2T6ZWL7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1080585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWL7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWL7"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="506"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="744" mass="79826" checksum="E4E2CFC9FF8D6351" modified="2018-07-18" version="1">MSSSNNPSPSVHLPQTMTASTSSITAPQQNPSSSNSNTPRSSTPTTTQPQASQNISSLVATILKTSGREPPALVGSSTTIIGDTLYAFGGRLLSRTKPQLTCDMYALDLITRSWSKLETRGDVPRPRYFHSVCALGGTKLVCFGGMSPAATSPLQTNGTSNTNGNTATSPGGDSQNDVMVMSDIHIYDIPSQTWTYIPTSNPPEGRYAHCATILPTSATFTSTNSVAAPVVEGLRLEGLGGAEMVIVGGQDSANHYIEEINVFNLRSLKWTSTTPLDRSCGAYRSVVAPLGRGLTASSIGAGRNSPYMGSEEGPSFSAVNGQSISQASPSEANAMLIYSNYNFLDVKLELQIRLPDGSLTERPMNGQFSPPGLRFPNGGVLDNHFVVSGTYLTSSKQEYALWALDLRTLIWSRIDAGQAFAQGSWNRGILWSKRNAFLILGNKNRSLVEDYNHRRINFSHLCMVELEAFGLYENPRMSSHPALQRSCSLAAQELGRVVLGMKEMADMEFLAVGGERVPVNSRIVARRWGPYFLGLLNAANKELPSPTGKNHNSASTITQQSLSQSTQKSEIQPPTTAQFNPLDRPRTLYLPHTLQTLLTLVHYLYTSTLPPPNHPQSSPQILCSLLQIARPYQVEGLLEAVVERLHQVLDGRNAAAVFNAAAMAAGGGNGGKREPVETLGGTGDEWRGGVSSVIGLQKRGLRGLMEGRRMRERGRSTGGSTGAGTRSSEAQMNQGTFGVGVGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX10</accession>
    <name>A0A2T6ZX10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1173582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX10"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="183" mass="20373" checksum="3E169BB9D57BF575" modified="2018-07-18" version="1">MYESLYGKMNGQLLASPHKTESFGKEAAYEWFNTLRLPVGLGDLPLHLDKDGWYSVLGSWNGASNNPYPANRVSEGNLENNHAIPVPTVDPTRNDRPTLQRIFCQYHRCSGNRLLLPLSHHYHSTYHITLTCTPTTTAALILAPQADLPARLPIVLGLEPSRLSKPLTGTTERCITATVWIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXA2</accession>
    <name>A0A2T6ZXA2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1045185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXA2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXA2"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="360" mass="40507" checksum="8121A1819D9A1B0F" modified="2018-07-18" version="1">MPDKGNEGVELINPREPTALVDDWTNVSDPQERRRIQNRLAQRAYRQRRAREHNLKIKFFHPAKKGPVRKGSASGGALHSHPAEIGDTSGASLIVENPPPRDPEPAGEASRLGKDKGKAIERPVHPAVNTPGFAVPNFYMLCANTGFIDWRMEEATARMVPVIKEPTIAPDHRLSADHYLIDLIYYNIYRAFESNIKTLGLTIQEIAQHDMISRFNSITLEDSVLESLGSVEAAPLQTSQTMHLPPALRPTLLQVSVVHHPWIDVFPSPRLRENLLRAGRSYDPDQLCLSIMGFGEDLGDNGVLVWGEPWDPSSWEVTENLAYGWAWMFEGCADIIHSTNTWRLKRGLLPLDLKVFHLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXN0</accession>
    <name>A0A2T6ZXN0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_758295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXN0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015562112" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13354" checksum="194A4EA27124D2F6" modified="2018-07-18" version="1">MFLLSDLLLRSLCLSSSNCCCFPTVHTGTYSIAQNASPVIYNHLPTLALALLHYWLLVPSCHHFGVTRTFLPQPAGIVLLQLRPPSLTHSLTHHSSLIDHHPSFSLLLVRSRSIERFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY67</accession>
    <name>A0A2T6ZY67_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1063467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY67"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="26879" checksum="BFD22001E459D8FE" modified="2018-07-18" version="1">MLEDSVAFQELEARWLNRCPSLRNAMLKVLNESEARSFKRYEETLAGMSDHLAGQEKFLQEGQNELFKHLKARDKRHDKKVKELILRNADLIDALLEERTKRMKLEGKYNVWGALERMVYLAKVEQKVAPRAGIQEGLDKLAKGREFTTALRKEARDRKLSVNDVMASVNHLYVQASKCADDNDDTFRNIIIVRASKFSDNERAALAVFFKIQSNWVNAFKWREDTSLKGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYE6</accession>
    <name>A0A2T6ZYE6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_730525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYE6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015654646" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12228" checksum="09435FB379E06EC4" modified="2018-07-18" version="1">MVSIKSLAVLLFAAAVTAAPLAGEKDSHDSVAVSKNTCQVDQKIHCCNDGGSSKSTSVVDLLNNPQIECNNLGVNVLAVPTLTDSSRCKGTIICCPGDNQQTGLVNANVDLRCTAPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYM0</accession>
    <name>A0A2T6ZYM0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_974449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYM0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYM0"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="125"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1077" mass="119735" checksum="6AAA2AAF3F5E0AD4" modified="2018-07-18" version="1">MSLSHDANSARRKSFAFFSKPNNSPETDTSTWPVRELITKQRPKSAFFTTGGTGYEEVATVVWTNIGSSRPRVLTKTPGQRPRSMFAPLRGRDPGSPQAESSESSSIDSSQSDNMNLPHPGSRVIIHSGEVFSGGGLLRKKKEFLVLTSDELLRYKSESKASEAFGLSARSPTTGRTPSIGSVGDLVSEHTLVTMMNQVVAVYRFACEGELACSVQVDHLDDANGTPSSATLQVGSPREAQEWVDILCQVSQTCRSVRPPLPFSDSTVKHIARRLEADRDYSPAHFQIFRIVQRFGKVQGRAGSNEDLHKMYSTICYLAIGTHKVHFVPVPKCPSNNSRSTTSLPSAATSSSYGILNLVGIAISDVDDSFTLTFRPPCRPPQRIHLASTEAPEIIQSIRQAAEYLRPNWLTPPFSVDIPQDMKDEPIPEIPPTPDDDYNGFDRTLSAYCTAYDLDASNIVYGIHTEVEDSPRFVLYPPAYSRRRQYTDLELLAVMRSLRWNEAFASISFHGINLEPLHGIFDMHGTENEPNCSRSGRHIHIKSTGNKRCSLLIHEIRALALYSSKLRRLDVSECMKRKARREDPTGTPSPEDGCGIVEAVMPLCRRGLTNCDWFDLTGIELVESDLDWLVDAAASRLAHFRGFELARCGLTERMMTLFLNALATHENTLESLNLCGNPGRIHAPSLNNSMSYFPFLRKLNLSRLLRTSGEDPLLTAETLLRWRLEDLDLSETKLNKQTIDAVAAYLASPQSDSLHHLTLTQCGLTSKDVAVFMNSMSRTPGEPRNMHLYVGQNPLSKHHDALFECILSGATPTHLTMRMVDYPKEEMFREFVTAMTANKTISFLDMSKVSLPYEASPETCAALGALFAENSTLKELDISGEQAVLESASLGAGLIDALHRLSENKTLEILRIELQSLGTPGAMELASMLTKNTALKEIYCEMNEIHLQGFSAMVNAMEQNKTLLYLPRMDRDRAEHVKCLKDKLFQPSKSAVKSAAKGHKGKDGKKEHKKLRRVSKGEKKVAFADDVLGATGVEQNLTLLEEKWESEAQRLLKFLARNAQLHNDRRLGSSFSDLVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ77</accession>
    <name>A0A2T6ZZ77_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1123126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ77"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="27982" checksum="19B70B853B6DCFAA" modified="2018-07-18" version="1">MEPTRLNPLNSTREDLYIFPTNIPKNQSIATILKTSLVTLRTTGKNPWVLGRYLALACQGGWSAVRRSTVKGIIAPEMLGVWVIEALLIKFLVKFDAKVEAGVDGATTFPTNSTIGILQSLKLMPRPKRKVILDWERSANWRAQRTLHENENGPGDGHQEKENQAIKKRVVIIEETARMANIKNRRHAYEKLELQTHVTRGAEDVPNLAKALQEDKEFAEFISIMVEGKAIDAGDCTNGEETTKPEEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZC4</accession>
    <name>A0A2T6ZZC4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_925181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZC4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7495" checksum="6DF9106D55A7CC86" modified="2018-07-18" version="1" fragment="single">DEKERDRPADEEKEKDRLADEEKEKDRLADGEKEKDHLANKEKGKDRLAGEEKEKDCPANKEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZC5</accession>
    <name>A0A2T6ZZC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_682159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZC5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZC5"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="642" mass="73146" checksum="46CA9030966D0768" modified="2018-07-18" version="1">MMNGDEPSSGSIAQFSQRSPLNPVLSLEPRPFPQLTTELQPSQQPHESAAPSFGWQTIGERQDFYDERDCLHPSFNLVIEKLNNRGADDVVIFDYSLDPDYLTLDGDSSDEEDGPPLEHSSADDDLFFRVSRNELLESEEFGQIIGSSERRPSRGPRLGIIDFPQCYDTWDDSLLYAMGKKLSLQQEGKSGFMDVYLRRVRELPGHRRFRTGISLWAPSKGLPGLPRSRSSEHRFLLFVSFPYFGGSSQDIRLDPESETVRLLDFGRVGIDVPDRSAIVDEKERDDIRRILVHQARYLVFDNNLMATFRSKEDTAKDRAPLHRFQERIGAFRAMTHMIANCTELELRTLEKLQASLCKLGGEIHQMISDARAYRDDWGMKREQDRIQDLLTSLDVLAASSFAAISVAERQIVVLQDLHSVFLTSYRTKSKDYEKGYPLRQNPFHRNILTIPILSENPQQIWPNTLDTIDEVVRERKYFIKKVKGLVENMDIRRKIFSAFLKSDQAKAAPSEKTAQETAGAVKRTEDAVKKTQAVIEKAQAELVQQGQTLTSFTIVTTAFLPLSFCTSYFSMQTMKEFGDSPGKLSLRQFWLATGPTLVGVLLLTVMIVLWKRPVVIALKANIKKKLSIHQRKMISDIEKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZM5</accession>
    <name>A0A2T6ZZM5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1063108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZM5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZM5"/>
    <dbReference type="OrthoDB" id="5419514at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25368" checksum="7FABEBEAA1ECC4AA" modified="2018-07-18" version="1">MRDSRWGTTPLLLLRISQLLLGVVVLGIAAYFASKYSGWYIAFTVALGFVTLVWTAVVLGLFFKNKLSPPLVMFVDVPLAVAYILSVATVAANWPRALGGSCVAKVAGVPGESILDADCATLKGAFGILIIEMLTFHGAIIWDAIVMSRNPNRRRDVRGVAQNYVPVMPKPMAVVDSGGPHGQYQLDGTLVYPAELASPAAQYNSDMPPTDPQQQQQYQQYQQSRGPPQELSGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A088</accession>
    <name>A0A2T7A088_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar protein,Nop52-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1077729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A088"/>
    <dbReference type="STRING" id="42251.A0A2T7A088"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="260" mass="30006" checksum="2E479313DDFF962D" modified="2018-07-18" version="1">MAEAKLQQTPFVKQLAANDRPTRDRAVASLRTYLSSSRNFTKIEFLKLWKGLFYCVWLSDRPRTQQRLVLDLAGLLDSIETKNVGVFLEAFWTTISREWNGVDVLRMDKFLLLVRRYLASSFRYLHARKWEKDLVGRFMDLLRETPLSPKDMKVPNGLRYHLIDIYVDELEKLKPEEMKAPLPVATLLSPFEELMLASPIKLVRAKSKELLSDGRLADWGYDKASGAVKSRRKEGSEDEDNDDDDEKMSDEGEEWGGIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0F9</accession>
    <name>A0A2T7A0F9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1077617</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0F9"/>
    <dbReference type="STRING" id="42251.A0A2T7A0F9"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU81229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="259" mass="28717" checksum="A10D4C5CF8BE1DA4" modified="2018-07-18" version="1">MFSVSRRVLGGRLALKSSAKLISPPTSSALAVRYQTINARPEPMGTRPQNTSIMGTKPQNTSISKSGFNDAPETLIDAGTEKVDWARSFHGLSTEPFSKEAADILLAPVDPEDVEIKPDGIIYLPEIKYRRILNKAFGPGGWGLAPRGETIVTEKTVTREYALVCNGRLVSVARGEQDYFDPNGIPTATEGCKSNALMRTCKDLGIVSELWDPRFIRNYKKKYCEEKFVEHVVSKKKVKRWIKKGDTIDYPFKVASFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0R6</accession>
    <name>A0A2T7A0R6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1113511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0R6"/>
    <dbReference type="STRING" id="42251.A0A2T7A0R6"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="64"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="156"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="211" mass="24219" checksum="03B7AB03F9F70622" modified="2018-07-18" version="1">MDIDDLLQELDDNQVPSGTRDIADLTQSWIAERSAPEILPFQTALLERLMERIRQQIELVETQTGNLDPKTNFCLILIQTELERVKFLVRSYLRARIHKIDKHSIYILTTPSIRGRLSPPELSYLKSHLGLLNSHFLASFLRGFPEHWGISMVEEPDLDGAVFCKVVKDIEDNIARIPGTDAEFKLTKGDVYVVRYSAVREFILRGEVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A153</accession>
    <name>A0A2T7A153_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A153"/>
    <dbReference type="STRING" id="42251.A0A2T7A153"/>
    <dbReference type="OrthoDB" id="1112980at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027921">
        <property type="entry name" value="NOPCHAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38489:SF1">
        <property type="entry name" value="HISTONE CHAPERONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15370">
        <property type="entry name" value="NOPCHAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="19895" checksum="A9326D95D02EA303" modified="2018-07-18" version="1">MPSNGGQEKGEKSNPSHPLVTDQNEHAPSSSPPSKKPKMTAAAADTSSDLMSRLNAFLPAMEAANKDLQAEIEDGTIGERNIEVLDGEEEERYIEMNLGLGVLEERKDGDGDTSEREEVEEEAEDDGEEEDHDILLKLLNSSKRHGKGPRGKPSIEVIEHSQDTPTPEKQATHHHHTGTEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A187</accession>
    <name>A0A2T7A187_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1077072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A187"/>
    <dbReference type="STRING" id="42251.A0A2T7A187"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="60511" checksum="3957E7092B366C9A" modified="2018-07-18" version="1">MGIFMRLINYTEDKRLHDYSLVSATLALLFLALFLLLKKEWSIHSSTKFPIVGIESPGYFGLVKAREKYISDAFHIVKNGYHKYRGKNFVVTAHSYDKIILTSDQINELSNAPDDTVSFSHFLAEVMQGPYTGMDRFLGTNYLAEVVRIKLTKSLGTIKEAIIEEVRFSLDTELLGCTTDEWRSVEIFILILRTVARTSGRVFVGLPLCRNEDWLAVSMAFTGDLFMAIEKLERIPKPIRPFYTWIFNSTKLISLHRKKAQTLLGPVIRERLEEERLAKENGSAYKKPSDMLQWLTDLVEPRHKNTKDLSELQLFASVASIHTTSLSFLNVLYDLAAHQECVQPIREEIEAVISANNGIIDRAALHKMTKTDSFFKESTRGQIDVLSFGRKILKNVTLSDGTPLKQGTLVSAPAAMFSSDPDLLEDPETFDGFRWYKKSLEAESRAAHNSNWTTTSAHHLTFGHGKHACPGRFFVTEELKILLTFIILQYDIKYPEGESRPATIKYGEAIYPDTTRKLLFKKLPGPKKFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1B0</accession>
    <name>A0A2T7A1B0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1B0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="171" mass="19153" checksum="CCB2B991CC5F4CC4" modified="2018-07-18" version="1">MRMSSSFLFSFQAAEADTGIPVAQVPFSTRPAIKTVRCITHRMFFADIIRQTIMLEYRYSANQRANEQHNSEQHRTNSTSLPLFLYRYPMKKQDPTCANVTNPICPPASKKKISPGSRAHKVKHEESAPESTIGTFKPLFLTSRPAAQPNITPPNHQSGKVISQRPTIAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1V8</accession>
    <name>A0A2T7A1V8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1099539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1V8"/>
    <dbReference type="OrthoDB" id="5370362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12488" checksum="5F860F4C6452BB8D" modified="2018-07-18" version="1">MSFIKNKLHNIVADVREAKAAVQSHNVGSYDAPPASNMHSEQHLPPPPPRSLPHGWTARFDEKEGKFAYCMGVDGVEQWEFHERWGSRGWERGHDVLHGRCARNCDRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2H6</accession>
    <name>A0A2T7A2H6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_525043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2H6"/>
    <dbReference type="STRING" id="42251.A0A2T7A2H6"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23114" checksum="F2EC4ECFB9278FCD" modified="2018-07-18" version="1">MELLIGGYSYGSLIASLTPPIPDILKLLEEPPPSTPAFAKALLTAKESARRWLDTHSSTRTSYSGTFNRAAVHAALQQEENRKLECEQARHGIDKKWKVTVRYLLVSPLLPPISSFMMGFAGMKAWSLGRGSVDEGEKGIEATDARVLAVYGDGDTFTGIRKYRKWREKMEDERWRGVEVGGAGHFWREEGVMRVLVSQTEEWVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3E4</accession>
    <name>A0A2T7A3E4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vesicle transport v-SNARE N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_916075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3E4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3E4"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="91" mass="10448" checksum="DD825824E8FB9BE0" modified="2018-07-18" version="1" fragment="single">TMLGNDLIASYEVDFKLLKTIIDRKLDDARDLYGEPRKAVMREIERAIDDADEILAQISEEGRVLQGVQRGRLRIRLRGYVRDMDAARSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3L2</accession>
    <name>A0A2T7A3L2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_968992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3L2"/>
    <dbReference type="STRING" id="42251.A0A2T7A3L2"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015589112" evidence="2">
        <location>
            <begin position="21"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="171"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="384" mass="39535" checksum="1919A7A20733F578" modified="2018-07-18" version="1">MLCFKPALTVILTLAACSKAKSIGELFSSTPELRNFTSIASMYPDFVTTLSGASNITVLAPNNKAVFNNMKIMPAGTRNNAEHIKSLLAYHVLNGTYRVGDFGNEPELLPTLLTAKKSANITAGEPQVVKASLMDDHVAVYSGLNKVSMVSRANINFAGGIVHIIDSVLALPVNVSMTAIDSNLTAFVGALASANLADTVNKLSGVTIFAPSNAAFQAIGNLVGGLSNEQLASILSYHVVLSRAFSMDFTNSQRLRTAQGGQITIRIDDGNMYANGAKVIGADIITNNGVIHVVNGVLNPNATNDEPDTGASTQAPAFPSATGSSNVPFTSGVPAPTGSGMAASFPSDTPTGTGRQPNVAASITSNVIIAAAGASLTFAAGMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3L6</accession>
    <name>A0A2T7A3L6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B9Z19DRAFT_968274</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A3L6"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="781"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="843"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="905"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="976"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1206"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1247"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1281"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1346"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1460"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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            <end position="1560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1572"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1602"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
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            <end position="1646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1658"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1757"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1795"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="136"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="264"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2009"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2041"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2089"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2172"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1431"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PUU82336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2187" mass="244697" checksum="08A7A7180EC38AB8" modified="2018-07-18" version="1">MTSNNHNPSKPPSPEPIPLQDLSRPPGAQQSDSSGIGLSSGVGRSRSLLRGTANLGAEIGRRISLHRHGRSYDRVPEDRLPPRPEVPDLQLPQYDDGEREMPNVVEFAEGFVDASGGRSGGRRGSWLPPRNLEQTISPWAVSDDDEPLPVRQYHGADDDDTARLTDPSNVQPISGSDLNVGHRRQQSSRSIRFGPGPSLGDGLLSAEEGMGPSASRGKGGTRSRPGSVAGGIPSRSGSLSKSRSLSPGASPVRRVSVAVQNMSQRVVNLSNDPEAVPQALRRRSSSKSHADGPVRPNIPAIQVHPHDDFDTSDGEEKPTTPLRRPVPSPGEGPWHVNSNPLRGNTLRIFSPTNRLRLFLCDVLVHPVTEPLILLLILIQTILLTVDAAPSIYNDPRTKHWGTSNIDYALLALFSIYTVEIIARCIVSGVFLNPRAENDPKGRGELRRRIMENTHKLLSPRRKPSVRAPSPSRPEQPPSLFRSLTSNLQLADSAIQVDSQCQARLRMARRAFLRHSFNRLDFVAVVSYWISLWLFITGVEAERHLYVFRMMSCLRILRLLGITSGTSVILRSLKKAAPLLVNVALLIGFFWLIFAIIGVQSFKSSFRRSCVWVDPEGVQGNFTQEFQFCGGHRNRLTGLEEPYVYEDGTPGAIFPKGYICPINSVCVSSNNPYGGTVSFDNIAQSLELVFVVMTANTFSNLLYYMADSDYLTSALCESLNSWYTGLGVVLILIAVITSSFQVIREESRKSAFAAEEDSSSKVDEEEFVRKPNSLKRAYDRTFYVWITVISVGLFAQAFRSSDMGHERETIIDAVELVVTLVLLLEILFRFMADWRNFHKKIRNLVDLALALITCTIQIPSIHRSGRIYDWFTLFQILRVYRVVWAIPVTRNLLSKVIGNVSGLTNLIMFVLLLTFLCAIFAVQIVRGDLPEKYQGQTTAASFHTIFNAFLGMYQIFSSEDWTTILYMATEVQRPYNVGWITAIFFIGWFILGNFIVLNMFIAVVQENFDVTEDEKRIYQVKAFLQNKDYSAPSQGISLSSIFGFGKQKTKEPHSRQVAFEMLTKPAVVESFLDEGAQHPRQLFARAQPLHAAAEDARRTGEVKQRPWERMKNRLLGVLGEKEPNPFYSFTSSRSIADLTPTAMAQQVVTEQERRRKAQREYLKKYPNYNVSLHIFGPSNPIRRLCQRMVGPSRANIRYDGLQPYTPFSYAFSILVYCAIVSMVIIACVTTPLYQKEYFEKNGNSLRNWFTFADAGFVALFTIESLIKIIADGLIWTPNAYLRGSWGVIDCVVLITLWISVITSFRNQGEISRAVGAFKALRALRLLNISGAAQNTFHSVVVLGGRKILSAAFVSLSLIIPFAIYGVNLFSGLLDTCNDDSEEIVNLTSCVHEYPSTPYGWEVLAPRAVDNPYFNFDNFGSSLFILFQIVSQEGWTGVMFDAQAIVGKGKQPQPFSSQVNSIFFLAFNLLGAVFVLTLFVSVFMRNYTEQTGVAFLTSDQRSWLELRKLLRQIRPSRRPKDSPDLDWKSWCYKRATHKHGWWQRTYTVILVLHAILLLLEYHPAPPALDRTRDWIFLGFTGLFVGNLVVRVIGLTWSNFLKSRWDIYAIISVNGTFVTTLLLLAGYQERTFIQLQKLFLVSIVMMLIPRNDDLDHLFKTAAASLTAIGNLMATWFVLFLVYAIALTQTFGLTRIGPNGNGNMNFRTVPKALILLFRMTCGEGWNQIMSDFEVTHPGCVHGKNFYQSDCGSQGYARALFVSWNILSMYIFVSMFISLIFESFSYVYQRSGGSSVVSRPEIRKFKQAWQRFDPDGTGYISKENFPRLLGTLTGIFAMRVYEEPFTVPDILDDCRVDPQSHGSSETHGIIEGVDLNALNRRIAMIPIHKIRRQRHIYTLFYEECLVSANKEYGVSFTSVLLILAHYKIINDNKSLRLEEYLRRRYRLQRVEEQVQRNIVTNFFLTLYWNKRFKDRRRAQSGVPQVPQIFVDDASSSRSDASPNVPQILVDDAEVSPNTSSASAALSKGPVTPKRQALPPLDLNYHAGNNQTPETFGTSGTPQFGDSDPFVSPFSGEESPSVLRQRPGRGRSADGSPSLSPNESPNMSPSGSPVGSPRLSPIATTSGWISRAGSVSAGGGSPSRSRADSDVVPQNVLEVLGSSEWGDQIRSYMERSGDQSPTRSNQGGSTSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A467</accession>
    <name>A0A2T7A467_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1061756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A467"/>
    <dbReference type="STRING" id="42251.A0A2T7A467"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="5"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="31527" checksum="CBB0D0E39CBED47A" modified="2018-07-18" version="1">MATRAANKRLVREYKAIVENPPPYIQAHPSESNILEWHYIITGPEKTPYENGQYWGTLVFPADYPFKPPAIRMMTPSGRFQTSSRLCLSISDFHPKSFNPAWEVSTILMGLLSFMTGEEMTTGSISATEQERRILAARSRWWNSTGGGSGVPDPVSGIMVPNHAPGAGIGTGGSRGGVGNGDLGRKFREEWKDVDAENWKWLKAKGFNLASGLISPPPSASARPPTSSGVAGVAGTDTEGARRRQRSGSIGNTGTAGAAGVVVRRGGGWFEGHRVFVGIVFLIAWALLARSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4N4</accession>
    <name>A0A2T7A4N4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4N4"/>
    <dbReference type="STRING" id="42251.A0A2T7A4N4"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="163" mass="17613" checksum="A3D876D41B3B1497" modified="2018-07-18" version="1">MSSDTEADAHNLNRAQRIEMIFSPISSTLETQHIVRTILRGEHESIVKEAEEGDDDTLMPIYAIDQDTVEDGGKIVLDDKIAGELTETPSPVSKIGDISERSMERTETGRERCVAAEAIAWLVGKLLGEVASRGAIDFMDPTLVVLGSHDISALEGVLLGSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A572</accession>
    <name>A0A2T7A572_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Homeodomain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1120001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A572"/>
    <dbReference type="STRING" id="42251.A0A2T7A572"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="54"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="105"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="7">
        <location>
            <begin position="108"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU82897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="434" mass="47202" checksum="4CF40A993363993F" modified="2018-07-18" version="1">MPRERRKWTEGEDAILRDAVLKGGEGACDWHLIASCIPGRTNKDCRKRWHYKVAATVNKGPWEVAEDERLWAAVQEHGSRWALVAQVVKTRNGDQCSKRWYDALDPSIDHSPWTPDEDVRLLEAIEKHGRNWKAIVKAYFPRRTSLSAKNRYSLLIRKMEPKNKQSQTGGSKKANQKSSQKLQSQVDTLEASKIPAPQFRQESANMGMKREDEHSRSHAYGNSLSGGAGGSLNVLFEPTCQPGNANNGGSGSNTNPGNAKQDQQPQQPVAFESPLLSQKGTPGISSYTPPSSDCPALSPADWSGLVTNGNAGSEASFPVATPPGNSEDMSLFFNDLHLTSSLSQGDLIQFAAKHPERMVARSISLDQGTMGSNRGIDFRGNITPRPSNAGQDAGGDTGSRVITVMINSEVPETVNSIVNHIGREEGVSIAIHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5L8</accession>
    <name>A0A2T7A5L8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III, clamp loader complex, gamma/delta/delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5L8"/>
    <dbReference type="STRING" id="42251.A0A2T7A5L8"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="278" mass="31636" checksum="8E0D21FC5AD36699" modified="2018-07-18" version="1">MTTTNRKIEFNIVASVYHIEITPSDVGTHDRVIIQSLLKEIGQTQQVDITAKQKFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILIANSTANIIAPIKSRTLLVRVAAPTIDEMVGVLKYVAELERFEFSNKLARRVAEESGRNLRRALLMFEALYAQNEVVKDNTPIPPPDYETLIGQIADELLADHSPARILLVRAKFYDLLTHCIPATTILKLLTFRLVAKIDDVLKADVIKWAAFYEHRIHLGSKVIFHLEAFVAKFLRILESYLMGMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5S8</accession>
    <name>A0A2T7A5S8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1073656</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5S8"/>
    <dbReference type="STRING" id="42251.A0A2T7A5S8"/>
    <dbReference type="OrthoDB" id="542917at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000007">
        <property type="entry name" value="Protein transport protein (SEC31), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="767"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="794"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="900"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="944"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="966"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1009"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="1041"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1054"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1084"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1107"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU83025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1238" mass="132783" checksum="9BDADD48B96FFFDD" modified="2018-07-18" version="1">MARIRDIQRTAAFAWSPDAAPFIATGTQAGAVAADFSDNTQLELWDLDLENAHAGGELAPAASITTDSRFYDITWGKVSNDKPRGIIAGALENGSLDLWSADALLNNSGDSLVSRTTKHTGSIKSLQFNPFKSELLATAGAKGELYVWDLNNTENPFLLGNRAARADDFDCLDWNKKVPHILVTGGNGGFVTVWDVKSKKESLTLNNLGRKAVSAVAWHPELQTKLITATPDDTSPVILLWDLRNSNAPERTLSGHELGDTDLLLSCGEKLGEFPVTQWNPRNPSLSATASFDGKIVIQTLQNTNPTSSQADSSGATQLDADDFFSRASNAQTSSFTLKQPPKWLSTPVGASFGFGGKLTQTGQPRRSTVKISTIAVDSGVNSATESFEKALREGNLVNVCDLRSQDAKTDEEKADWKILRTLFEGDPREKLIEYLGFKEEGLEDTNAEVDTKNTDGEGENQSSNQSDDAAAKDKRLSSFFADAGADSESFLADLSSIQSTRGAKTNNPFRIFTGGESEADRKITRAVVLGQFEKAVEVCLKEDRISDAFMLAICGGEKCIEKVKTAYFTKNAKGPNYLRVLASIVGKNLWDVVHNADLANWKEVMVALCSFADGKDFPDLCEALGDRLEQELGPAEGRKEARKHASFCYMAGSKLEKVVDIWIEELHEDEKAGLEEISDDSTFAVHARSLQNFIEKVTVFREAVKFSDEEKNLSGGWKLHVLYEKYCEYADVVASHGQLEVAERYLDLLPTNYPAAAVARNRVKEASGKGVTATQARKPQQPAPTGYGTQHHQATNPPYQPQQPATAAVGPANPYAPPALAAAPVNPYGTPTTAPQPGPYAPPAPPAGANPYAPPTVAQGYKPTPYQPTQTAQAPGQYGAGYPGYNAPGFGQPPPPRNFGQTASVPPPSQASNMANWNDTPNVTKVPRRATPSATAPVTSPFPGAPSAPSPPTASMPFGAPPPRGSSSPAQYQLRSQSPAAQAQAPYTPTSQTFPPSQPGYASAPPVAVAGRYAPTPAAAGAASQPHQNQALPAPPQGAFVGGRQGGPGAQYAPPPTAFGQPPAPSPYAPAPPQSQGGQYGAPPGPSQYGPPPTQRPSSQPTQPGTAPPPKARTPVPPPSKHPAGDRTHIPSQYRPIFEFLSSDFERIKPRAPPMFHRQVKDTERRLNILYDHINNEDVLSQETLESMLELSKALVAKDYATAHSIQVDLVTNRTSECDTWMPGVKRLIEMSRATPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Y9</accession>
    <name>A0A2T7A5Y9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_965533</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Y9"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Y9"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01512">
        <property type="entry name" value="ATPase-IB2_Cd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="193"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="276"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU83144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="982" mass="104194" checksum="23486DFE7345B625" modified="2018-07-18" version="1">MDFGDDRGEEKKLAQTTIAVNGMTCGACTSAIESGFTNIDGLESFTVSLMTERAVAIHDVVKLSAEQIAEIIEDRGFDATIVSSDMKGRPPGGGRGRASASGLVTTTIAVEGMTCASCSSSIEGAFKSVDGVRSIAVDLGTDRAVATHDPAKISAEKVAEIIEDRGFDAKIVRSEPVGGYGRRSISDSTPHLATTTIAVEGMTCGACTAAIEGGFKDVAGIGSFMVSLVMERAVVVHDPDVISAEKIAEIIDDRGFDAKIISTDLQRSEDRDAREDTIIFKIFGLNSEEDAIKLENSFRTCEGVTDAVVTLPDAKAVIGYYPSKTGVRNLVDIAESLNMNVLPADMEDNSAQLESLAKTKEIKQWQHAFWFSLYFAVPVFYRSAFKSLKHGSATMDVLVVLGTSAAFFFSIVAMLISIMCLPHTKPSTVFDTSTMLITFISLGRYLENRAKGQTSKALSRLMSLAPSMATIYVDPEKAGLSMGSDGNAGEERTIPTELIQVNDIVIVRPGDKIPADGTVVAGESYVDESMVTGEAMPILKRKGALLIGGTVNSAGRLDFRVTRAGRDTQLSQIVKLVQEAQTSRAPIQRMADILAGYFVPSVIALGLITFVGWMILSHLCISVIVFACPCALGLSTPTAVMVGTGVGAEQGILVKGGAALETATKITQVVLDKTGTITIGRMTVAVSKQAITTAAREHLGLGPATEPRVYKVLIGNTKFLNESSIEIPEEAINEAKGVSLAALSDELKLDAKYAVEALRRLGVKVAMVTGDQEAPAHQVAKQVGIPLSMVYSSVSPDGKQKIIKSLQASGEIVAMVGDGINDSPALATANVGIAMSSGTDVAMEAADIVLMRPQSLLDIPAALHLAKTIFGRIKLNLLWASLYNILGLPFAMGLFLPLGLHLHPMAAGAAMAASSVSVVCSSLLLKFWRRPVWMTIDGMKAEEASGLDTSGSPNMGWQSRWMRWRIGRRAGDGYAPVGTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A612</accession>
    <name>A0A2T7A612_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1119742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A612"/>
    <dbReference type="OrthoDB" id="5423286at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="256" mass="29573" checksum="914B79AD3A7AABA9" modified="2018-07-18" version="1">MPEGITYLDMKRMLVAQIPPGLYRIESHTQFHRKDQFLGGDPTLLEQYYDKGFFLNPLEIETWGKALAISLPTLWLRWQFALHGHAVPMKASEYRQILDSWKLKPGSTENVQIQMALVGTEMCIVFLDRNRLMQASIIPKYPTTTESMGVWYDTSLAPCPILNFPAFKYNLLLPQNQEDLRDQSQSTTVYTHLTDTKYNHLWNGIGTSHAVEILHLAGIHPEEKMQNIWGKISLKKKLIKTIDQYFIMAQLPKIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A658</accession>
    <name>A0A2T7A658_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1073287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A658"/>
    <dbReference type="STRING" id="42251.A0A2T7A658"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="316" mass="34990" checksum="F3209928F6D25224" modified="2018-07-18" version="1">MTEQMILRGTLEGHSNWVTALATSLENPNMLLSASRDKTLIIWNLTRDDISYGVPKRSLKGHSHIVSDCVISSDGAYALSASWDRTLRLWELSTGQTTRRFVGHDNDVLSVSFSADNRQIVSGSRDRTIKLWNTLGDCKFTITDKGHTDWVSCVRFSPNPQNPVIVSAGWDKLVKVWELASCRIQTDHTGHTGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLSAGKEIHALVFSPNRYWLCAATASSIIIFDLEKKSKVDELRPEFIAGGKSREPECVSLAWSADGQTLFAGYTDNLIRAWGVMSRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A685</accession>
    <name>A0A2T7A685_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A685"/>
    <dbReference type="STRING" id="42251.A0A2T7A685"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="481" mass="52216" checksum="68DE757E4E0B9A95" modified="2018-07-18" version="1">MPDEPVANAPPNGEGGIPMTHVHAVTVPGAAAAWVDVLETFGSGKIGLAGALEEGIRLAEEGAPISLLSSVMWAQEVENLKAASPNYAEILKGGTRAPKEGEIVRMPHLADTFRELVRHGKKGFYEGRVAQAIVDVIKSRGGVMELEDLKNHGEAGSEIVQPVFMEYGGRRLWECTPNGQGLVALMALGILDNLQKEGVVPDFGKGKECHWKHNSAEYLHVLIEVLRIAFSDGRHWIADPKVVKVPTEGLIDKAYLAERAKLFNPDKRNDNIDHGTPAFQSCDTVYFSVTDKYGNACSFINSNYGGFGSGIVPKGCGFVLQNRGCGFSLHPDHPNVLAPRKRPYHTIIPSLITDTDNNLDAVFGVMGGFMQPQGHLQVFLNLLVWGMNPQQAVDAPRISVGKPYDPRVSGVSVEEGVGDSGVMDELARKGHEITIVKGWYRGIFGRGQMIRCRLDEEDGDSKTRVWSAGSDMRGDGHAVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6R3</accession>
    <name>A0A2T7A6R3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1072560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6R3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="167" mass="18314" checksum="B88B3BA5229AF869" modified="2018-07-18" version="1">MPAFYGIQSTHSQKGISIRPFPMALQSSLKGESLWQLDSRGVRHAIMKPFYDGVQRHPLCLPPKGLPHTSIFHGATESSEGGVHILGFLDVWKVLTLKPDSGGVRHAIAKPFYDGPFYDGILRHPICPPPKGRLHTSIFHGATEFSEEGALMAGVLSADFIARFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Y2</accession>
    <name>A0A2T7A6Y2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Y2"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Y2"/>
    <dbReference type="OrthoDB" id="5392440at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="242" mass="25902" checksum="264F76864BBB6EC5" modified="2018-07-18" version="1">MSFCSSPASQRSSFSSTYSVDCTSPNTAVTTPSSSGETSPKLRQSYTYTQSPSPDALDFSYPYNPTSPIPMNEYPPSSSASTSYAYSCSNQIPSPSPYTYNTTPSPLPASPSNYGYLGYTNFMPESPPLLPSSYIHHLRSHTPPLPMDSTSSSSSGSMGGGGVAAPPRKYSGYPPASAFYGPMPNSPTHPAPSSSSSSSSSSRYRKKYSQPINPEEYKSESWYTADGTKVEYSAMHLQCATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7R3</accession>
    <name>A0A2T7A7R3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1104911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7R3"/>
    <dbReference type="OrthoDB" id="5413544at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="633" mass="70981" checksum="61661229814F9DEF" modified="2018-07-18" version="1">MGTMTDWISAICSLVAAVVALITLLTVYQASIQILNRRQLYHLGLSKNSLGPWRSVVASSSILRMQTQIMTPTLSVPLLVSKRWEPKISYPVGFELGLKGTEADLEAGGVALARASWVNFLEGLGVSPEDDGDFYEMRYESELVNGIVPMRWEGRDLAAICSILGFQSIGSKPNAGKLMELPTQWCGPLGWLQFRASSEGCIVEYRRRSVIKNQLSQELHDYYKGLDVGSRPFKLKSRLWQSISGMCFSDQKVISLSDASEWAEKMRNREENAERPFDEACEVFIECEEKLTDDRVMGILFGKKANRPEGLQPEAFKNGMSQLSPQHTRGISDLLNSEVKGIEDNSKKMVVLYPSRGHLAVSTEGELVHSRGLEKDDLYEYSYIYRDEDEVGVYEHKLGRLCMDMELLKHMKEAILEIGPDGFYFSPSKLLNFQVAQIWSHACSVSERCLDQKCILPIDSLELSAGEEAKKHASGEELYYAIKLINNFQLIKSTSRAMFTTADMVLISRASVSLRRLIGSGGKDLIWAILASPELFDRLLYHITNTTMKDLLDFSLTCKSGRFDLKLVKCSEPEAGQAADGIKVELVEDGTFEGIQVVAALMDVFLNLFWIDRSWVTDVALYDTTMPQSVTMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7V4</accession>
    <name>A0A2T7A7V4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_962615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7V4"/>
    <dbReference type="STRING" id="42251.A0A2T7A7V4"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="64"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="38914" checksum="0045CF2ECB24D548" modified="2018-07-18" version="1">MLRSPLPGATAALHAKENSRAKKWREMAVVRKRGERGEEGGKGGGTDWGFVTVDAKLISRTWKGIPDCWRAAAWHAFLTASAKRRGIGKSDTELVTIYTDFIERPSADDVQIDLDVPRTISSHIMFRRRYRGGQRLLFRTLHALSLYFPEVGYVQGMASLAATLLCYYDEETTFIMLVRMFELRGLEKLYQAGFGGLMQALDEFEGGWMKGGQVSRRLINLGVTPTAYGTRWYLTLFNYSMPFAAQLRVWDVFMLLGDPDPASSAIAPAFSGSLDVLHATSTALIDGMKEILLKSDFEGSMKVLTSWIPVKDEELLMKVVKGEWKGRRKRRAKGGGGGGGEGLGGASPALQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A809</accession>
    <name>A0A2T7A809_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1038192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A809"/>
    <dbReference type="STRING" id="42251.A0A2T7A809"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="121"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="787" mass="89919" checksum="3B8F2CEEDF56FC5E" modified="2018-07-18" version="1">MDSHPPIPWEPPSSGNGPMFTPLDIQIFKIGAPLFAISFAVYLLLYSKNPYAIFFYNCFLKPFSRGSIERSGDQQYALESFYKGQAGIYDATRGQLLRGREEMLALAAAQLKYRIKKVGKKVVWVDIGGGTGYNIETLNKYLSVQGFFSKVYLVDLSPSLCDVARERFSRLGWKNVEVVCVDARMFRLEEKVDWITMSYSLSMIPDFYSVIDSLSNLLSSEGIISAADFYVQSSANFAGRTYTGGVLSRHVNWFSRQFWRMWFEFDRVNLDEGRRDYLEYKFGTVLSVNERNRILGGVPYYIWIGCQKLHTVTDVLALVEAAATESPFLSPIHHMSKVQANAQPSDTMLKLRSKGFEAAALNLAANIPLPSALYQNRHWRIYYDELLQKHTQFNNSYIYAFTWEDPRVDQRVLKISSDDIVLAITSAGDNILHYLIEGSPKTIHAVDLNPTQNHLLELKLAAFSALPYEDIWKIFGLGRHENFGELLVNELSPHLSSRAFQYWFDHRRVFNPRSGGGLYETGQSRLAIIAAKWLFRVFGVSKHVERMCAARTLNEQREIWRSKVRPVLLSQWVSWAIIDREQFLWRALGVPGNQRDMIIHDHPQSAQGQGKDSGRTMWEYVVNTLDPVAENTLLGEDNYFYYLCLRGQYTEKSRPAYLYPKSHYKLSRPGALDNIHIHTDEIKDVLTRIQPGALSIAVIMDSMDWFEAGSAEAREQIKLLNAAMKVGGRALIRSAGRNPWYMRVFEEEGFKTARVGNRSPGACIDRVNMYASAWLCTKVEERGKFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A822</accession>
    <name>A0A2T7A822_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_962265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A822"/>
    <dbReference type="OrthoDB" id="5333877at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015656338" evidence="2">
        <location>
            <begin position="22"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="7455" checksum="CE814961F262C2BD" modified="2018-07-18" version="1">MRLPTSSQVFFTASVLSAVQAAPASNSLPTEINDLVTRAFSDSPSGGYAPGRASCPSGPLVPGLPQEATAHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A845</accession>
    <name>A0A2T7A845_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1112187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A845"/>
    <dbReference type="STRING" id="42251.A0A2T7A845"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="34998" checksum="402898819E35A059" modified="2018-07-18" version="1">MANLLPFKTITRYQHFVYPASHHTCNFPRYKYFSSLSVTTIISHRAKQANYRPIFDKLAHSSATQSSNMATTNAPNDEAGRPKVTLFWLNQSRAQRIVWLLEELGLDYDLEVYRRVDRLAPPKAKEIHPLGKFPVVKVNDDLLAESGFITEYLVDNYGEWLKPKDRASLMRYKYFLHYSEGSFMPPLLVGIVMQGVKNAPVPFFLKPLVNMICSGVETKYLLPNYKTHFDFLESEISQRPWLTGEEFTGADILLSFPLTVMKGKSIFTQENYPALWAYTEKLTGREAYKRATKKTEAMEGDKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8I4</accession>
    <name>A0A2T7A8I4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_557523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8I4"/>
    <dbReference type="STRING" id="42251.A0A2T7A8I4"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="156"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="567" mass="62992" checksum="574B482529CFFC7D" modified="2018-07-18" version="1">MEEGKVTTEKEVDRLIQKMKAPILGIDFTRTGRPRRASTHLLTVGPQNVCDVMDDSSATNFVNPGCCGGGCSRLPEGSVSLGTSSGTVSDFVKAPDNAAFKSLNLRLSLLTSRDKLTGITALPAQTISLEPVDEEEKHESTVYVHPPKYVTPHPPWTVYSAKIDCARELTKPGAPKRTYHFDLDVTDYPEEIAGVDFRVGGAIGVVAPNDFKRVAEILDILGIDEDERDAPIQLNTQGGRWPTIWGKAKERALTTTLRELMTWTVDIQSYPPTKDLIRLLAEYAKDQAEKTILLYLCSRQGQAAFCELRTGPYISLIQLLNAFPSSKPPLDHLLCNLPTLMPRFYSLSSDPRESKSKDHRIIEIAVTIHEHEEGWRKGNRTGVGSGFFERCARRIIDEGANDVRIPMFRGLMANPLAKQFQADGPMLLIGAGVGIAPFRGFVQRRLQSANCANKVWVIQGVRDSLLDELYSGEWGEHEDKIRSVVQSRVGTGRYVQEEVFAQADLVWSIVNSVDGRVFVCGSSKGMGEGVHESLVKVVMKKSKLGREQAEEFWEQKKKDGQYIAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8I8</accession>
    <name>A0A2T7A8I8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1189122</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8I8"/>
    <dbReference type="STRING" id="42251.A0A2T7A8I8"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="379"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU84033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="512" mass="56850" checksum="B236288D6825D1BF" modified="2018-07-18" version="1">MVLDYSKWDALELSDDSDIEVHPNVDKQSFINAKRRQIHEQRAMRKQQITSLRIERSMNEVLLSRVSKLISTLDIGSKSSKSPEEIVFQSLMDISSADNDPQEFTPPEGTPSYAQMMASLIDSIKKEIDEEKPDDRWTHFLNKLKEHKVKLTGVYEDSGKKLADLEKEDNAKITSDSIHVGFSAGHVTKEAQPPKKEPAKKTQKVQAVEQLNPSVKAKGSSSSDVDADIEEGDEADEDEDHIEPTELGKEFSRIKMGDYRTCMEFISRNPAVVVEKETDGLLIEAFNSQIAGKEDYAKQCVHQALLLQYCRQLGRDGVALFFRRITTPNHQAQKVFHEDVTTTYARIRERAAAIATERSNENAEQIQLHAVDPNTQISIAVPSADSVDPDTQKSRGIFNTFPPGLQRALESGSLDEVNKVLGKMSVEEAEEVVGQLGEGGMLSLESQIIDATTQEGLQVLKKIEEEERAAKANASGPSDIAERDSKGKAVGGEGKSKEEEALKEEDLAKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8V0</accession>
    <name>A0A2T7A8V0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1060421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8V0"/>
    <dbReference type="STRING" id="42251.A0A2T7A8V0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="144" mass="15740" checksum="1CD7674E2E2992CD" modified="2018-07-18" version="1">MSILRDCYRCFGLGVDIIDSSGSVNRFCALESASICGSTNTEEKSGSKLIDTHNTIFNMGGSFWIVAMLSMTSPSALVQSLSLKRTCDITHADSTIRCVTAQIIYAKKICPNYLPGNSQSNDILSLKLKSNTYMGEDGEFNMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A966</accession>
    <name>A0A2T7A966_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A966"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="92" mass="10021" checksum="BE6A5A595F48905D" modified="2018-07-18" version="1">MNEPVRSPSNEQAAYISPIGLCLGWGWGCGGAGVGSKIGLFRTVAGLPRQASFFWYLEILTAEVTVTVIRRRKQKGVRAVIEAEGRLLASWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A998</accession>
    <name>A0A2T7A998_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1070032</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A998"/>
    <dbReference type="STRING" id="42251.A0A2T7A998"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU84308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="9426" checksum="1ED98DCA9EB587DA" modified="2018-07-18" version="1">MHPTRKLFVLPRSTYYEPDQRQGASLIRARKPFLIKNVITGLVMFGITASIYVYTIRAVSQDEFEDVKVPEAPGRGVSKEVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9H4</accession>
    <name>A0A2T7A9H4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_899460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9H4"/>
    <dbReference type="STRING" id="42251.A0A2T7A9H4"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="2">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="148" mass="16109" checksum="115425B72AB88BFD" modified="2018-07-18" version="1" fragment="single">GFYILNIIRCSSVISLLLAIVAAGISLVKSFVVTKFYFFDAINNVFLSIFSLLVMSEISVFQSYFDKRWPLLGSKSSLITIGIAEVIVGFFLLGNLNETAASKQNLGYSFNTLLTSAGVIVSFVGVVNFAASYVYSDSSTHTTARMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9T8</accession>
    <name>A0A2T6Z9T8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1011436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENND6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000612">
        <property type="protein sequence ID" value="PUU72257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9T8"/>
    <dbReference type="OrthoDB" id="10265409at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024224">
        <property type="entry name" value="DENND6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13677:SF0">
        <property type="entry name" value="LD41638P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="40"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="519" mass="58296" checksum="14D8B779148D90B3" modified="2018-07-18" version="1">MAGENGTLVSGDISSYTAALYANELKEYPFNLGALRKWMIAFVVCDFNVDIGVEVEYMFPSTKFSPADLQTICFSSFPERTNSDATEDSAFHFRFRHSSPDVSCQTANEDPAYWYGFCLFRQQRDTAVKRNYRQKSLVLVSQHDYAPLFAYLIKTISLLDFEVSPTLIESACSNIAAWGPPEVGLQELPFLGSLLDVHIPPHPAFPLQGLVTATPSRTDIRVEYKEIHTSEPIGSWTRLAGLLNSISELYIIFERVLLSDPVVVLADDPTTCSEFVSAAVDLIRPIPFGGDCRPYLTMQSGMLTPRCPRLELTVVPLGITNPFFLKRLLSSGKENKTPYVVYLAGPEVKRKHHLHFYTSITERDHPNNIIANDAKAFIEKDHEFLRMLENQLKDPGTTPLECGRFIRRHFAHLAAMFLAPLNRYLATLASTSSDSSIIDIAGFSEADFLASLSKHGCSVQFKGKTGYHRHRTAEAFYRKFCRTPNFFRWLEMKMRLQQAPLEVIGAGPVNGYGEKAGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA78</accession>
    <name>A0A2T6ZA78_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1097351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000547">
        <property type="protein sequence ID" value="PUU72401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA78"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="68" mass="7944" checksum="15AB023722733122" modified="2018-07-18" version="1">MATLHHPPWNRLHFFPPPKPPSERRLKSTNAVPALYLRKRTLSDRMIGSEWHGRSHCSEIGLDDTRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAE5</accession>
    <name>A0A2T6ZAE5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000529">
        <property type="protein sequence ID" value="PUU72472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAE5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="218" mass="25045" checksum="13A469A0872EDEA0" modified="2018-07-18" version="1">MAPPHSGRENKPPEKLFDRRKQQRRLAITTLLAHLSGTLLNVEDSSWPLEIFTSFPKQSKTKTLLEMQIPSPRPLEENHIDIDWVDDYVGLSGTDFRNPHGNIIKAIHDMEAKMVSIGTELKSEMAKSQGDLKNAIEENKVHPVFELAKRYWEYKYTMAKKRSEFGSGIGGSDSSLEVRMEKLDFKLYILYLLYFIMIIPWPTEKPPARPSEFAPDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAE6</accession>
    <name>A0A2T6ZAE6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1097201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000530">
        <property type="protein sequence ID" value="PUU72471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAE6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAE6"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015601010" description="B30.2/SPRY domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="900"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="954"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1171" mass="130367" checksum="AA953F2B098CD2B0" modified="2018-07-18" version="1">MEGLSLSTNIIAVLTLAGQLLAAGYQYGSSSAHFPSELRHLVQEVTALSGVLHAVKMLVDDPAVNTRTTNGSSRDLMASMGEPVEQCRKLMEEILRDLRKYDAASRKRGAWRLCWPLKEKATKKWCERLERHKSLFELALSVDEVSLAWEIQNDVEDIKEIQLLNKQDEKKAVSSAKQKRIRDWLSPADPQSNHLAARKLCRYGTGRWFTEGKEFQDWLKAGKSFLWLHGIPGAGKTILSSTVIEYISAKFVKEPGSMLAYFYCDFRQVSKQNATSLMGSIIWQIANRKPTMPRDVEDFFSAGSGDGPPKLASLINLLRRLLVRIHKLAIVVDALDECPDSLQPVVLETLRELSGLSNVNLLVVSRDHLNIKLHFEGLPSLGIQKKDVAKDIELYISHEIERNGKLKRLSSYIKREIIDALVKGALGMFRWAKCCLDQIGKLRSDKAIKSALESLPPTLDETYERILCNITEEDRELALQVFRFLICGDRTLTLSEISEALAVEIGSERMDPDNRLNDEEDILDICGGLVDRNEKNVAGLAHFSVKEYLVSPNLAKSKASYYYIAETLGNTELAKITYTYLLLEDFSTGPCSTTAEFDLRQKEYPLIMYAAQHGWKHVLGYKYGSDAALDGLLAQFYSSDNNPNFISWRQVQCFLGRDITGYLNSRTSSASTLYYISEVGLWQLIKGIIGRGADVNHYGGPLYTPLQAAAKYGHIKTLKALLGCGANTAPIGNSDAMRAAAGAGHVDCVKALIEAGGTSDNQDIGPYGASMEEAALSGHEGVFTACLSTKYYAKTEDNTPFWVVMVYAATMGFDGTIQMLIQKYGSRIICDNNEHFPRTLKTLAEYGRTKTLQYILQQPGAIAILLRDDVFPAVLEGAVYYGQAKMVELLLRNKKKDSLELGVSFHLATARGLPKISEMLLREGADPRAKDEHGWTPMFYAMQCLKEGSVERLLAVLGPDEKSGIMNVTGMGPGGWEVIDNSAELEVSENGCEVENISTSERQIRAKFPITPVVDDYYFEVRILKGPEGCMIGFVDAMFHYVIDGFELYSSYLGRTLRSWGYYAGHIFPEDELLSEPALVFTTNDIVGCHFDRVRGAVSFTLNGKRAGKPLPGVRGKLRPMIRLTPGARVRTNFGSEPFVHEIPEPAAPEAYVRGPPGIWPLTLWFSHPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAY0</accession>
    <name>A0A2T6ZAY0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000493">
        <property type="protein sequence ID" value="PUU72633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAY0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8384" checksum="9285E193954558F7" modified="2018-07-18" version="1">MSTQEITRAASYFYPSYSLVDTLYQKNSALVHVCAPRLREVHQGGSARTRKDHGDQNPPGGSGAFRTTLDHAKTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB74</accession>
    <name>A0A2T6ZB74_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1096742</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000480">
        <property type="protein sequence ID" value="PUU72696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB74"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU72696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="22865" checksum="335C94CF1F3F5E27" modified="2018-07-18" version="1">MVEILPAQADEAKNETAGVYAREEGRKKKAIPKGVVLDKDGKPCRSCTSFRDWAAMTEKKIASPQPKEPPSTTTAATSLPLDCPPDVETLGRSTWTLLHTIAATYPTTAPMEKQTEMKTFINIFSRVYPCWVCAEDFQRWIELPENRLLPGRQGGHLSGRASFGQWMCGAHNEVNRKLGKREFDCRRYEERWRTGWADGRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB92</accession>
    <name>A0A2T6ZB92_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1096783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000483">
        <property type="protein sequence ID" value="PUU72684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB92"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="58" mass="6609" checksum="30BA523244815AA7" modified="2018-07-18" version="1">MAQVLMRSVESARLTGRETPLNNSFHYGTAVPLAWHRGDTMTCRAVRHGWQMTCCLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBB3</accession>
    <name>A0A2T6ZBB3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1096659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000474">
        <property type="protein sequence ID" value="PUU72736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBB3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBB3"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="28246" checksum="A50B30A6CEA04F1F" modified="2018-07-18" version="1">MPTHAPQNPDPPKTGPNDSIVKKIYQGEAPDTTDTSVRWAAYANRIQTIMRSGQRYVAYTSDIGESFRPVVPKTLVRSAYGISWAYLTGDVMNEGYKAYLANQATLRGGLRVTDVPVFLQPAHMIKNRQGGNKEEVVPNEDPGHTKVELHPKGNVPFLEDYRTVMVQRAVFQSLASMALPAFTIHSVVRYSGHALKNHKNPKIKAWGPVGLGLAVVPALPYIFDHPVEQAVEWVFEKGYHVATGRSGVSEKEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBM0</accession>
    <name>A0A2T6ZBM0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_608504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000446">
        <property type="protein sequence ID" value="PUU72897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBM0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBM0"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22728" checksum="950B5E7656F9EE71" modified="2018-07-18" version="1">MLSSAKAHHSTPNITYTHLDANHLPLSTTSTILQPQTFTKIFSNAALHWILRVPPAQRTAILKSLHNLLVPSGTFAAEFGAHGNCAEVHAALIAALVHRGVAVEVVREACPWWFPSEEEVKELWTEAGFVVESLQVELRQTELPQGDVGGWVKLFGSAFLELVQEGEREGVVKEVMSVLESIGRVGGSNGVFRINYVRCRILARRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBM6</accession>
    <name>A0A2T6ZBM6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1104179</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000446">
        <property type="protein sequence ID" value="PUU72895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBM6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBM6"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="481"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU72895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="715" mass="78962" checksum="04978E58FDCF47E6" modified="2018-07-18" version="1">MFVSSCSPSWCWGNLLQSQDLLSAPRRGEAVPNKSGSLAVFHLSSYSFDTHGSSSSWSLLNLKDGGTTVLFSDPTVQEVVWLDDESLLYINGTSSDIKGGSELWIAKYSKPSEGYKAASLPAPVSNLKTVSPSDKTVNFVVSALTYSNGTIYNQESAPKKLDTGLIYESLFVRHWDVYDKPEKSSLFSGVLSLDDDKFKLKKEIKNLMADADGAIETPIAPFGGADDFDISPDGRTVAFISKTPYLNPANNTQVLVYIVPFDGTLKPKPINLEGKDTNGHPLPEGAASSPKFSSDNGALAYLQMYINGYESDQNNVFVYKIDSSSITALWKPWDRSPSGLLWSGDDKTIYLTAESYGRVRIFEAHIDDDTPKEITAEGNIVALHPLPSGDLLISRNSLTSSIGYSIFNPSSKHFKTLLLPTDVDPQLADLSKITVEGFSFDGAETKVHGFIVKPSDFDSSKKTRLAFLIHGGPQGAWTDSWNTRWNPALFAEAGYIVVAVNPTGSTGYGQAFTDAIQNQWGGLPYIDLVKSIEYLEDTEEYNYIDFDKAVALGASYGGYMINYIQGMPLGKKFQALVCHDGSFASQNIYSTDELYFPQREFNGTLWDDPENYSKWSPSAHIKNWGTPQFVIHNALDFRLPISEGLSVFNILQSLGIPSKFLTFPDENHWVLKPENSLVWHREVLGWINRWTEARADKVIAKVGKVQAVLNAQDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCI7</accession>
    <name>A0A2T6ZCI7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1005573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000401">
        <property type="protein sequence ID" value="PUU73211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCI7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCI7"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30369" checksum="3A16758C00089223" modified="2018-07-18" version="1">MGFFGVLVSYVAPLFIITSPLTSYADQIRNIHITKSSRGFSLDIPLIMLVASILRCFYWLGADFETSLLIQSIIMIFVQLLLLKVALDYRPPPHLPLLPLTPTASPTSTSTSHSPPFPPYPPTPRPYNFWQWPTQKPYWSFLLYFTLTTLALHLLFGSSQLFIDMVGYLALGVEATLPIPQVLSNQRSRSCNGFRLSVLASWLLGDVMKILYFFSAQHVGVQFKLCAGVQFTLDVYLGVQFWMFGGGEGVEEGVRRREVEMVERGEMGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEC3</accession>
    <name>A0A2T6ZEC3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1161317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000339">
        <property type="protein sequence ID" value="PUU73847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEC3"/>
    <dbReference type="OrthoDB" id="3215839at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37289" checksum="51D624E196D843A6" modified="2018-07-18" version="1">MPQYLPNTSLTSMSIGPRIFAYAQGYHGQLIEAQGRLNNTGEHADVYYANGQTSIGPTTRWRDKYLIYVDDENILHDVVYKDSEWKPGTLSQYQHGDHIGVRCAPYSKLAAATVPIEGNTIICVYYQTTEKHGPVSMITFLPGNSWTELTALLQLLASLRDPPLYGTSLSAVKPRAGICLEQRKKKGDEITAEQSKTFPVVYLQWDTHALAHGQGKTIRPIPGLEEFGLSPHTSLSVVDDGTNLYCFYITNANKVEMIRIEQGQATAVIDDIVSPTPRSAIAAVMPLQQRDRIILFYQVWDTGDSEKIDIKAQTFGRGKGGADDWQSMLTTDLMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEF9</accession>
    <name>A0A2T6ZEF9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.216</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA 2,2-dimethylguanosine-26 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA(guanine-26,N(2)-N(2)) methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m(2,2)G26)dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1196593</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000335">
        <property type="protein sequence ID" value="PUU73888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEF9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEF9"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 12" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="619"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU73888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="686" mass="75144" checksum="CA0E016BA8BF8641" modified="2018-07-18" version="1">MGKRTRTPKQEPIAPNPTPAHAFLVTLEDGVECTAVREGLATVLFPKTVAKKDKSGNDVKAEGQVFYNPIQQFNRDLSVLAIRTFGEVFLKEKKGKKAEKKKKQGDEDGRGKEKEAAAGWGDRTQEGGGEMEEVLEGEGGQRKGEGDPMQEKPMKANIPPKFTILDALSATGLRALRYALEIPFVTSTTSNDLDPSASQSMRRNIQYNKTHTPKTIDPVLTPDAAMSKIHVETANATHHMYSVLSPPKPRTEEEHADGRSRDHRFGKYDVIDLDPFGTAVPFLDAAVQAVSDGGLLCITCTDAGVWASTGYSEKCFSLYGGMPIKGEWSHEAGLRLILYATATAAGRYGCSIEPLLSLSIDFYARVFVRVRRSPQEVKKLASTSMMVYNCDSGCGSWRTQPLGKRKEEKNKNGNGTYLKFGLAMAPTTSSECPDCGFPMHLGGPMWSGPLHSPTFINHLLSTLPAQPPEIYQTLPRITGMLQTALQESTLPNSPFFFVTNRLARTLHCEAPPMAAFRGALMRLGYTVVRSHCKPTSVKTDAPWDIIWEVMRRWVRQKPAGEGKVGEMMAGYKILRFGMMKDNGEVSAREKGKAGKEKGEVERLTSLEVVFDEGLGKDKDKVKGVPRYQMNPTANWGPLTRSRGVETVLEESSAAKGEEEGQAAEGEGGEGGESDEEGNASKKARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZES2</accession>
    <name>A0A2T6ZES2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1093914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000328">
        <property type="protein sequence ID" value="PUU73997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZES2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14786" checksum="8A71F41E639972E0" modified="2018-07-18" version="1">MRRMSNEISRLSRSMDGFKDALHDFRKDINELSTKFHRLSDKVTDLSNNLKTLADKMALLSDRITRVNKTLVIIKWQLSGLLILGFGFPLGVVLWIVKLGRDLFTGDNEDLLRAVMKQYLATKFDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF56</accession>
    <name>A0A2T6ZF56_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1001661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF56"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF56"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="126"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="346"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="621"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="758"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="841"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="966"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1046" mass="114224" checksum="6868F84F019E1BAE" modified="2018-07-18" version="1">MAGRKNESGPSMTLPHTRPPFKNQRTNSSTQSNSLPSTPNHHPRQANGASRSPSPTPALDSPRSAASEPLIPSIQKAPAVSPRTCIYETGLANIRRRMPYSLGIDKLGNEKPKAERLSVEQEGKFTEAMKSLFEKLKPSEASGERRRRFLEKLERLLNKEWPGHGIQVHAFGSTENHLCMIDSDIDVCIKTSWDGLKSTCYLAARLAKCGMERVVCVPGAKVPIVKIWDPEYQVACDMNVNSTLALDNTKMIKTYVEIDERVRPLAMIIKHWTKKRVLNDAAGGGTLSSYTWICMILNFLQTRDPPILPALHQRPHKKRPPINGVDISFDDDIETLKGFGHNNKETLGELLFAFFKKYGHELDYEKKVISVRHGKLLSKEEKNWQYLQNNRLCVEEPFNFTRNLGNTADDSSVRGLHLEFRRAHKILAEDADLAAVCEQYEFPPGEPHISIPVQQPAHRPVTLSRSYSNHKPRGGYNNRGNRPQHYMNGNRNGNRKPGNNNYNNHSNNVPLQHHYLSPEIFGYVQTPQEQLLALQAQFHARVAHAQLAQAHVHAQLHGQQTQTQAAGGSSNAHGSTLTPQDLAAVNPLSSYAYFAQLWGMNYYYPSASLHSELPTQMAPQVATGVNEPRQRVGQRRHNGYNAGSRSQSQPPPLSEVYSIPSYRRGGSSTTGVTGSEDDDFADHSSNGNPATPPEEEPDEYVGYYAYGGSLQSVPAVVDSVGEEEEPFVEQKSIVDRQSISLGGPGSFEDRGPVIVNGSISGSSVPYPDTPHSGLPLPSDELYQYDGSMSSVDLGESERSGGKSLDSKAIKNDTSSLAQKLLEVHIQAAVGHPEAGFTSSAQTQTYANGPSSASVSTSSLLFSPQNTQPSQGTSDDDVVASVSPRLSPNLRQRAAREQLLWSNARVPPVDNAKSKIAGGSQEDLAPPPTPAPEARSSSPAPALISAPTQVPTQAKKESSSALPPKSGHNRQSGRRGGKNHSAQVPPTPTDKSSKNPGVPRGNGNSNNKQNSGTKSDTKTSFKTSKHKKRSSPKTNDSPINEADRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFC1</accession>
    <name>A0A2T6ZFC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000317">
        <property type="protein sequence ID" value="PUU74185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFC1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="17550" checksum="54163DCE2E9C2385" modified="2018-07-18" version="1">MFLSLNLKRKSTKLSRRARPKPETIFAMFRKLNYYHRKELLGNREQSSLIPQGRVKYYVKRYKNQKEATKKDRTVAHFRQALEINTHNFRASGKSRGDEQLRDVRIQLQDKLKKMKGRTVSYRAKGTRSEIYESHKGPKPIGKAPTGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFM0</accession>
    <name>A0A2T6ZFM0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAP-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_462777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000308">
        <property type="protein sequence ID" value="PUU74298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFM0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFM0"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAP-associated" evidence="4">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="18153" checksum="832A2F4D2347A059" modified="2018-07-18" version="1">MIIHFLINVVDPPVLINLQNTPISEDVPPDQIFDESGEGEHQIWYAKDIENLPKTTNQMHIGQLLHSFFEYYSHRFQWGREVISIRTQGGIFSKQEKGWIAAVTRPGRGGQIQSDLTSTTMSSFASSKFANLYGPKLLAAIIPSVTVIWATKHGRQDIKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFV4</accession>
    <name>A0A2T6ZFV4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1093009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000304">
        <property type="protein sequence ID" value="PUU74365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFV4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFV4"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="360"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="481"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="758" mass="82740" checksum="32885442EB29F815" modified="2018-07-18" version="1">MAGVYKLTAALRGHEDDVRAVVFPSPYFVTSVSRDATVRLWKREDSEGTVFSDHINSTGSGFINSVTFILPTEEHPKGLIVSGGQDTIIEVREPDSKDIDDAKYLLLGHTHNVCALDNYAGIIISGSWDGTARVWKGWENQYVLDGHDQGVLAVLVLSETDVVTGSADKTIRIWRNGKTIKKIEGHTDCVRGLCRMPNGGFASCANDGTVRIWSLDGHQLQELHGHTAFIYSVAALPSGEVVSAGEDRTVRIWRDGDCIQTITHPAISVWSVAVCAQNGDIVSGASDRMVRVFSREEKRWADQGALEAFENSVAASTIPSNQVGDVKKDDLPGLEALAQPGKKDGQVIMVRNGETVEAHVWSNAARAWNNVGTVVDAVGSNRKQMFEGKEYDYVFDVDIQEGAPALKLPYNASENPFEAARRFLEANELPISYLDTVGQFIVKNAGGVTLGAQEQSTGPDPWGMENRYRPDAPPPQQAKPKRIPQKSYLSITAANLPTIQSKVNELNKGLLDSGEKDIALNPDEVSALAKLCGSLQAVASPSYKAGAHNTAFSGGLELISKIITKWHSQSRLPGLDLLRLVAAATPLAATYEPINGLKAGDILETSGAFDISHPNNVMLATRTFVNLFQTEEGRDYMDNRFEQTIQLAEKASDGTTNRNLKIAKSTLLLNYAILITSKRAIDRAITLLEPLTNIVKKEIDSETIFRALVGLGTLLTLQKEVKEAALSVYEARQTVTEVEVRIKEPRIKDLATEIRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFV8</accession>
    <name>A0A2T6ZFV8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1056399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFV8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFV8"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fungal kinase associated-1" evidence="8">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="420" mass="45647" checksum="9561A44AF70B722B" modified="2018-07-18" version="1">MERPVSLVLPTNQPRAISQGGRPLNLASTNNTIPIPHTVEKGGIAKLGAQNQGLGITRGGVGGKSRVVSAPANRNVSLASRHPNRQSDIPTRVDKFEPAPLRIRPKSVVNRHVPIDRAGDGGRNSKHLSQLPVVKDESAGFDTELILPSAYGGERQSLKLVNEETRAIAAKVNPVMSGALVAPAVNPLAKEVKKKRSFFDVLKGRNKLAPEPKDPVVEEIIVGGAKGTFGRRSGNLLKRWASRDAGGLLAFGASNDRADTQSIANGLTSCFTVPQDSKEGSDSFGGFEEDQFTKVMSQRNWFMKFLNVKPASRVICFNISPMATRKEIMKLWKEWVKYGLVIVEDDRKSLVMRARVGTPNSLNIKEVSFVGEIRAYGGSRKTGSGVVRFTQERGAASSFNRVIGEMAKRFSEKGIILLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFY1</accession>
    <name>A0A2T6ZFY1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000303">
        <property type="protein sequence ID" value="PUU74395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFY1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFY1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="13120" checksum="8416BE5567D210E0" modified="2018-07-18" version="1">MAQAILQAIDNAVEAHEPKSLVFDELDRDVASQVLAHLEQPKYSFGESGFRLHYSAPDRYLKLVSSTEIHESAAGWMMREVTFWFGDGRLDAAALDKIMGWKPSNERGRARRALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGM7</accession>
    <name>A0A2T6ZGM7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000286">
        <property type="protein sequence ID" value="PUU74632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGM7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="16823" checksum="CA9E48F8C898DAF1" modified="2018-07-18" version="1">MPFFSYFYRTNIIEKETSPSSVSSLHASENTPCTDPKHIPGEGLPERQSGSMPDCMKEHAPGEGIDLEHRANSLMKHVFGEGVDPECMRNAMEEYTLDRGISLERKRDLVRALAPGICINSECMSKLNDRLCAWRMDCAQASEDSDKEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGN0</accession>
    <name>A0A2T6ZGN0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1055671</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="NESQ01000283">
        <property type="protein sequence ID" value="PUU74653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGN0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGN0"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06450">
        <property type="entry name" value="DOPA_deC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU74653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="561" mass="60800" checksum="4089D278B57FD8E2" modified="2018-07-18" version="1">MTGSSRVPVSLRNFASSKKAAVKNSSFLLLNLDLFRNIVFAFFILRHFRRAVRKLRGRGVFGTLVDFYSAVQRYSYGIFLNFPGIRSKVQSQVDEALKKMEDKLVPKGPGVTRFLALPKEGMTELQVKEELKKLSEMEHASWEEGKVSGAVYHGGDDLLNLQNEASRIFSISNPMHPDVFPGVRKMEAEIVAMVLAMFNAPSGAGGITTSGGTESILMACLSARTKAYVERGVSEPEIIVPSTAHAAFDKAGHYFGLTVHHVAVDPVTFKVDLKAVSRLVNYNTVLIAGSAPNFPHGILDDIVGLSKIALRRRIPLHVDACLGSFLIPFLEKAGYPTEPFDFRVKGVTSVSCDTHKYGFAPKGSSVVLFRTKKLRSYGYFVSATWPGGIYASPSLAGSRAGSLIAGAWASLMSQGENGYTNSCRDIVGAAKEIESGIRERLHPDLFILGEPMVSVVAFSSKTLNIYEVADELSSLGWHLNALQDPPALHIACTRPTVSVVETFLKDLEKAVQSVKLRGEGEPGSKAAVGEITALYGVAGSLPNKSVINTMATGFIDTLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHC5</accession>
    <name>A0A2T6ZHC5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1103220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHC5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHC5"/>
    <dbReference type="OrthoDB" id="4095816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="667"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="95368" checksum="9D374925DF5B0260" modified="2018-07-18" version="1">MSGMGATFYPGKDDYYMMPEVAIVSPAPQRVMPEVPVQIADSLEHLELQSQNGKAPAESDGYMSNNNPQNDRNHLNSRQQTRNNYSDSYATLPPSSQGHGSRPMSEEHDSRSSYGASSYHSSIADDYLAGFQTIDEPSFSPFPKLLNPGPNIPPTDEEKGDQIEGARLAVLSSNDPEMQLIWAQDALSYVEVCMNYLTRIAEPPGTRPQTPTIEHQIKADALSVVTFLADQHHPRAEFMRGNWLEFGKFGYRSDKKEAFRCYARSAEKGFARAEYRMGMQYENSNEPMKAIKHYNQGAALGDSASNYRLGMMTLLGQHGQKQDYARGVHLIRLAAQTADENAPQGAYVYGMLLARELPGIEIPELFLPLDIRQAKEMIEKAAFLGFARAQLKMGTAYELCQLGCDFNPALSLHYNALAARQGEPEADMAISKWFLCGHDGVFEKNEELAFKYAERAASAGLATAEFALGYFYEIGMHVLADLKEAQLWYGKAAAHGNKDASGRIEGISRSKTLSRKDHESVAISKIRARHASQRRVVNPLTQKRQSVVPPIISPIEEAVDMPDPDIPPSGNYGYPLGPPLVQEPPRPLVRQGTMPNVNTSFIAPDLGQSYINHGSGPLSAVQPPRRPGTTAPYPVRPGSAGSGAPSHARPMSAVGYAVGGPAMILPAGTYPGGPPRPFTAMDNQGRRPPPGGRQQQPYPTVDEYPLPQGRQGPGQPGGFNGGPIPHINTPKPSQAHGNQGIKPPGTPIDIGFEAPAPRPKPAKSPAPSTVGGPNSRHSGGAGDKRPGSSLGPHSQQRPPNQQAPPNKAHGPPNKTHASPPLGPAPGPPSPPVNPSQTPKPPPSSATPKPQSTPLPKPPGKGPKTFEEMGVPQQTKEADCVSIPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHE1</accession>
    <name>A0A2T6ZHE1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tat binding protein 1-interacting protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1132274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHE1"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="6">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="25451" checksum="F87C2D8A64C3FB0A" modified="2018-07-18" version="1">MPPKKEKKEQVTGDQASSLVLEYLRQQNRPYSAIEISANLHNAVTKPTATKILKELDERGEIEGRASGKQVVYHIIQVRPLVPNLEITDDLIIIGLKDPKDLASPEELKVMDMETEAVKQEIGGLKAELRALHSTLNTLKAAPTTASLRETVALLEAEIQNFQVQLEPLRSSAVKPVPVEEKAAISNEHTRLQKILKGRKNQFKEFWDTICDGCIDVNPSDLWAGSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHJ4</accession>
    <name>A0A2T6ZHJ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_996747</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHJ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHJ4"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="18">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU74967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="20698" checksum="0641CAF980CA0F32" modified="2018-07-18" version="1">MLKIWSMKQQQQAASAAEGGQKKKKVTAAQLRAQKDLSELSLPPTIRMHMPDPEDILNFTLTIEPDEGMYKGGSFNFTFAINSNFPHEPPKVKCTQKIYHPNIDLDGNVCLNILREDWKPVLNLNAVIVGLQFLFLEPNPSDPLNKEAAEDLRLTRENFKRNVKNSMNGGHVKNVQFERVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHM1</accession>
    <name>A0A2T6ZHM1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Gamma interferon inducible lysosomal thiol reductase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1116648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000257">
        <property type="protein sequence ID" value="PUU74990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHM1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHM1"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015667263" description="Gamma interferon inducible lysosomal thiol reductase-domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30129" checksum="A25F349FF38AD925" modified="2018-07-18" version="1">MSCRTAIIFVSVVVILFTSRINPPPGALAYYVIRHYPPSPSVGKQQPLGAPSFTAGTKVPLEIHIMSKCPDAEDCLELLIAPALEEIEPLVDFQMSFIGRPTAGDGISCMHGPSECLGNVLHLCAAEINTPPSPPPAHTYLPFSLCLERGYGNIPDREFVEGCADKNGIDFQKLNECASDMGPNGGLSMLRKSVERSKLLDAETSCTVRVDGRRWCVRDGGRWKDCDGGSGFEDLVRDIKKIYKEKNGDHEKLRGKGKKLSEWIESERIIWTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHT5</accession>
    <name>A0A2T6ZHT5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase III transcription factor IIIC subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_996355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000253">
        <property type="protein sequence ID" value="PUU75057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHT5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHT5"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="195"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="420" mass="47481" checksum="0461724B819A7D42" modified="2018-07-18" version="1">MPRAPKPPPRPQPLPQASTAPHQSRGGYAPWHTIPPQKIISIEHPAIIKNVDKAIETLGGAKALKKLSETNASSGLDLRFRPEDIMQPPIQSKTVATNNILLKIRIPKRKRTSGEGPDERSVLEKLRDARGEYTVEAVGVIARTVRFRDMANYQFNTADMDIVQRVRVELGGLEYEKIKNFDIPPSRGLSDPHPILPPPAFSNTAMQHNYHYRQNPAIKKTLVAGKPALLNLQAAPKTLTPMVHISAPAVPLHPPDSLRPYDLLDRANKQCVDHLRKLFAQRPIWTRRALFNHFPKNLQSLVRFSMVHVAYMWRAGPWRDTCVVYGLDPRADSQYRTYQAVFFQVDTEKTAKGREKVRTGASHIFDGKNLVRDGRCFQLCDVTDPLLKGVIDGARVRSKCDVLSPLYPTRHFAYRLIFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI24</accession>
    <name>A0A2T6ZI24_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1054640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI24"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI24"/>
    <dbReference type="OrthoDB" id="5397805at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="26267" checksum="E5147777845546A9" modified="2018-07-18" version="1">MVGNDEDMIISSRDALRTAVEQDELFFGHDIEPLTVGNTRGLGLASLPGRMKVLETTVASQGQKISRIDSLEQRVEDLTLSLESYKLLRHRSIVNYKNANGENISKSDNKYGNLVAHGGDAKADSELYRDMKPRVDYQIFKILYGFHPQIVWSITHPETLHVLNTHATIKADTSQEVTPKFYELFDHFVREFEESEFDPGYLEGNPTLVTKAYGEFLRCYEVKVKKVRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIJ2</accession>
    <name>A0A2T6ZIJ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIM-barrel enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIJ2"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="11"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="287" mass="30219" checksum="D9BBD2CD22C46C8C" modified="2018-07-18" version="1">MQRPPATRAEALQRLRDTLTAGSAIIGAGAGIGLTAKFIEAGGADLIIIYNSGRYRMAGRGSLAGLLPYGDANAIVCDMAKEVIPIVKHTPVLAGVCGTDPFRSMPRFLTELRGLGFIGVQNFPTVGLIDGVFRQNLEETGMSFSLEVEMIRIAHEMGMLTCPYVFTPEQAVDMALVGADVIVAHMGLTTKGSIGAGTALDLDECVVKVQAIRDAAVAVRSDVLVLCHGGPIAEVDDADYVLDKTTGVHGFFGASSVERLPVEVALEKTVKDFKGIIIKDSSVGGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIK3</accession>
    <name>A0A2T6ZIK3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1102996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIK3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIK3"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38416" checksum="04204AE8D742BFDD" modified="2018-07-18" version="1">MIWSWRILWEGDISSVFPSLSGIAPPLLPGWYAELKRLFAAGRERVLAESWERLLLDLERETAGVKRLGSDIFEFKDLVSLSKAKIKDIKKRGVVVIKNVLPEKEALSMKESLKEHIKRNSWAKVVAFPADSPAVYELYWSPWQRAARAYPSLIASQCFINSLWYSSLTPSIVDTSVSLPYADRFRICQPGDAGFALGARIDRGSVERWEDLDADHRDGAGSCGVWRSCQGWLSMSTTPPGEGTLLEFNNSTHPHLRLDDVMTHVPRISPGDYVFWNCDTIHSVDRSVLYIPAVPWTVESQAYVERQNEAERRGGLPGGFSRSTTPVYHSLAFPQTLYLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ54</accession>
    <name>A0A2T6ZJ54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_994193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ54"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ54"/>
    <dbReference type="OrthoDB" id="248233at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04165">
        <property type="entry name" value="GTPBP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03694">
        <property type="entry name" value="GTPBP_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03708">
        <property type="entry name" value="GTPBP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000014">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000091">
        <property type="entry name" value="Probable GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035531">
        <property type="entry name" value="GTPBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF9">
        <property type="entry name" value="GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="178"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="578" mass="63147" checksum="1432FBDA87BCEB34" modified="2018-07-18" version="1">MATSARADKQIAYDRRRAGELALSDFAEYVEQQQRLRRPGGTAAGDAAEDHDELDIIESLGLADDSQPNSALKDLLLGPREENGPWLRELLLSRIKEGRGETLFEVGVDNNNAESMEFTKEEYEQAMEAVRTAAAEVRAAVTVLITSNLGADGEEPTDGKGVTSTVLIRQKPESLEGLLEIRVAVVGNVDAGKSTMLGVLTKNTLDDGRGRTRVNLFRHKHEIESGRTSSVGMEILGYDAESKIVGSNDPGRKLKWDEIGNRSAKVISFTDLAGHERYLRTTVFGLLGTSPDYVMLMVAANNGLIGMSREHLGIALALNVPVLVVITKIDICPPQILKQTVDQITKILKSPGARKIPIFIKNNTDVVNTAKQFFDTNTSFEFHVNDCFSVPFVGTVVSGVVKSGVIHAGDPILIGPDSLGNFITTSIRSIERKRIAVPVCSAGQSASFALKKVRRREVRKGMVVLPRTDSPPKAHQRFVAEVLILSHATTIKPKYQAMLHVGPVSQTCRIIDINKDLMRTGDRATVAFEFCQRPEFLCAGDKLLFREGRTKGLGIVKSLGYDTNTPLERDEQGKSKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJS4</accession>
    <name>A0A2T6ZJS4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1089618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJS4"/>
    <dbReference type="OrthoDB" id="5453998at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="19424" checksum="89F90CDE8E1A2644" modified="2018-07-18" version="1">MTQEKRIFRSRKGVSDDVAILFEAMGVNCKPYPVVTAGAKDPFLGWFGASRKQFSDAPKACTKAETDSDLAAMRVQTAEVLELVKAALPASTKHLRVVLGIPVCGNRIRKKLPVPKKPKTFKVPKASVSAESCMMPATPNGMKPVSAVRTPSPKNAKVKIVQSCIRRSPRIKNSQGVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKH7</accession>
    <name>A0A2T6ZKH7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_992543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKH7"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="406" mass="45144" checksum="927A06B5FD2B74B4" modified="2018-07-18" version="1">MSLSGPSHFQHRASDDSDSSMGTSRDNSASRSTVPSSVPSLEQHGSKTASPTESEILDYHHTHDPRESVNTYCSTVASFEDLVDEDYLYHVPHPHGYHHKAPPPPQAVPSTPSEFGELFPSTRCLSIRHDDSTLDGNMNLRVAHIKRKTTKPTPQRPKLQRSVSKALHSFRGKTEVEPVMKLNRQDSGYSSSGFDDEEEEELKSSSEATQNTNICTLEFSNYAHVDLTRRGGKVSKKYDFEYWGKSYSWKRVVKQVGPHAGAEEISYQLTNNGTGNVVACIMPDLLSAAQAQAEEAKGGLVPPCSFWLRDSIQDPIVSCLADVADVIMATGLTALVDDCIKRRFHKKKTVQLVLPMPMIKNPMKMNLEYVGPKRLIDEVFNRRPTLSRSQSTQSSQSPLPVRSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKQ8</accession>
    <name>A0A2T6ZKQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000205">
        <property type="protein sequence ID" value="PUU76063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKQ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKQ8"/>
    <dbReference type="OrthoDB" id="10659148at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="16581" checksum="2476CEC3E923411F" modified="2018-07-18" version="1">MEVLEKAGQEEEVRKVVQASHAERGDGEVHSGLIIVALGRVALIGIFQARLVELDEPVEKGVKNFSPSPMARNSSAEPPGGKGAGSRPNEARMPWLQRPAARQTPSYSNHGNIADPHLRESSVPTEPNYSEGHEPNDSASLTGEDACSLRYSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLB1</accession>
    <name>A0A2T6ZLB1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA photolyase, FAD-binding/Cryptochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1115961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLB1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLB1"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="5">
        <location>
            <begin position="30"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="397"/>
            <end position="399"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="511" mass="57196" checksum="4CE1ED5BB1ADE7DD" modified="2018-07-18" version="1">MTGVRQKPIETLLSALSVTRPARERLPIGDYVVHWFRGDLRLTDNTALSLASRAARTAGEGVGLVGLYVLSPQDLEAHVVSPAKLDFALRSLRVLKGDLEREFGVPLWIEVVKRRKDVTKRVLELCRRWGAGRLFANMEYEVDELRRDAKIVKDGVGYGVSVEVVHDLCVVPPGDLSKRPFTAYTPWFEAWVENIHSRPSRLELFPPPERNPDSFREAHASLFDSPIPSAPPRKALEGKEQAEYLASLYPAGEHAAQARQKVPEGPGGRLPDMLSVHFASGTLSARQAVRPAEDANSIKAFDRESKGIQTWISAVARRDFYKHVLVNWPFIWYAPLHPQPTSTTPLTESHFRAFCTGHTGFPIVDAAIRQLLKTNQPCTLNIDWRRGERFFMEHLIDGDFASNNAGWGWCAGAGVGPQRYFLVLNPTKQSLQFDPSGEYIRTWVEELRGVKEEEGRAVHAPFQILGEEGVKQIGYVAPLVEHEVSRARFLEAYKGGSGGKKRLIDSSYAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLS9</accession>
    <name>A0A2T6ZLS9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1129770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLS9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLS9"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="635"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="643"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="737" mass="79691" checksum="9E9BA1BF2529DB5D" modified="2018-07-18" version="1">MNNTLTYTADAPSYEDAVNTGRRVPPTTHELTPYLGLRARLSQVWFNRWTLLLFLVLVRVILATQSLDGDLRSARREALSACTGVESMGSAMASMPHYMSKGVNEVAAMGIETAVKALEKTLLLLITGVQEIVVFVINMITSTYVCLITMAVQGSLGAVLNATEKIADFVNNTMGKIFDDVGKDVKTVQDGVNKVSKALEKIPNFFGGGVTLPAVNFPSLDELKKVQIPTSFDDDLKKLKDGIPTFDEVKKAANDAIRIPFQLISKKVNESIGVYEFDRSVFPIPEKEKLTFCSDNPKINNFFDGLESTVNKVKKILIGVIICLAILAVIPMGYREWWNWRSTQSRAFMLHTAPTYDPIDVIQIASRPYSSSAGLKLASLFESSRRQILVRWAVAYATSTPALFVLSLGIAGLFGVLAQYILLRQVESAAPALAAEVGEFADIVVKQLTAASTKWAVGTNAAINSTNSDINKKLFGWVVNGTDSLNDTLTVFVDTMYEGVDKFFGKTPLATPIKDVLNCLIGIKVKGIQTGLTWANQNAHINLPLLPNDTFSLGAANSIAPEASGASSFLADTSSQASDMITDVVFKLTAKWEKMLTEEAIISACVVGIWIIVLIIAIVRTLVLFFTSDKHRGEAGGLPPTPVTQQSASSRGANINGSGRVATLPVFPAFSRSSKDSNGGGSPASRESMSPADAYYGPTEKVDSDARWLQVGGSVAVENSEGEYRRSVHASVYPGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMD1</accession>
    <name>A0A2T6ZMD1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenylyltransferase and sulfurtransferase uba4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Common component for nitrate reductase and xanthine dehydrogenase protein F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase adenylyltransferase</fullName>
                <ecNumber evidence="14">2.7.7.80</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Adenylyltransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A adenylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Molybdopterin-synthase sulfurtransferase</fullName>
                <ecNumber evidence="14">2.8.1.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="14">Sulfurtransferase uba4</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="14">Sulfur carrier protein MOCS2A sulfurtransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">uba4</name>
        <name evidence="14" type="synonym">cnxF</name>
        <name evidence="17" type="ORF">B9Z19DRAFT_1066458</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and mocs2a. Its N-terminus first activates urm1 and mocs2a as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and mocs2a to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards urm1 and mocs2a. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + ATP + H(+) = [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:43616"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.7.7.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48612"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12159"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.80" evidence="14"/>
    <dbReference type="EC" id="2.8.1.11" evidence="14"/>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMD1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMD1"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061605">
        <property type="term" value="F:molybdopterin-synthase adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061604">
        <property type="term" value="F:molybdopterin-synthase sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rhodanese" evidence="16">
        <location>
            <begin position="353"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="14">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="14">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="116"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="177"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU76606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="460" mass="50140" checksum="CAAC9E1317F0FF4F" modified="2018-07-18" version="1">MKTILEAENEALKKRISELEAQLASRSNDASVTSQQPYPPPNAANKSEVKLSLEEYKRYGRQMILPEIGIEGQMSLKRSRVLIVGVGGLGCPAAAYLAGAGVGTLGVIDHDTVENSNLHRQIIHSTSRVGAPKVVSAITYLRDLNPHPNYVPHVEPLTTENALQIMAEYDLVLDCTDHPAIRYLINDVAVVMNIPIVSASALRTDGQLIVLNNPPGVGPCYRCVWPRPPPAESVVGCGEGGILGPVVGLMGIMQAIEAIKIITKNPARDIGRTTMTLFAAYGASPFRCLKMRGKKAGCVACGSPERVGEKITREGIEDGRMDYVAFCGGRAGMRELREDERVSVAEYKEVVDKGVEHLLLDVRDKTQFGICQLAGSLNIPFSEFEDSKHEDSEAEAIKSKFQDQPKDRPVYVICRLGNDSQIVTRQLKQAAIFPDDQVFDIKGGIAEWARSGIAGEFPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMF1</accession>
    <name>A0A2T6ZMF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phophatidylserine decarboxylase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1129421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000180">
        <property type="protein sequence ID" value="PUU76669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMF1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMF1"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022237">
        <property type="entry name" value="PsiD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF9">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G01730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12588">
        <property type="entry name" value="PSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-tryptophan decarboxylase PsiD-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="407" mass="45857" checksum="1537C028819BACCC" modified="2018-07-18" version="1">MWPNNLLESIESKESAEEFRPVIQEFKDLIENDPTIYMFFHQMFSQIPNEPQFDRDPNGNLQVRDHLTMLRCFNEIMTSAPEYQEGLILAGCPFNAILNWPMGTPSGISAFLNEKVNAQVGKMLKEWAKFLGSPESRYVLTNSPEGGWFGPAALTQKQMNNFDKIFICQPSEPYHGFKSWDNFFTRELRDGARPIEAPDDDRFIINACESAPYSLRKNVQERDLFWIKGEPYSIKHMLAGDSFTPLFVKGTVYQAFLDILSYHRWHSPVSGRLVKAYIQPGAYFSQSVTAGFDEAAPNGSQAYLTEVATRAILFIEADNPDIGLVCFMAVGMAEVSSCDIRVPIGQHVKKGEQLGMFHFGGSTHCLIFRKGVDPIFDLPCEPGSDASIIPVNRAIAYVPPRKINAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMH3</accession>
    <name>A0A2T6ZMH3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1066438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMH3"/>
    <dbReference type="OrthoDB" id="5495785at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015402458" evidence="2">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="186" mass="19549" checksum="1FCA9D5E1265176D" modified="2018-07-18" version="1">MASPASISGVPTALLIIMQTLIAVSALPTPTTTTSATTTTTTTTSVSPQLERRQALDHSSNGMSPVLAATLVNSLGCGWPSMLVPTGQQPQPDEWTNKALGIPLPSPVSTAVTTLEDTSVMPAPENPISSPVLIYNDYSSTHLLGTYSNTFRNSQNGITGEDGIAPQNLMQFDTLLRAFVFVTTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMP6</accession>
    <name>A0A2T6ZMP6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1028321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMP6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMP6"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="2">
        <location>
            <begin position="167"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="392" mass="43672" checksum="DCD8B616DA0D965F" modified="2018-07-18" version="1">MPSTPRRKNPDENASGKKFVQTKLNFYIKGASSLSSSVSSSPRNRPTNSAPLASRGRYIREDSAEHKEFGTSDLESQPQETDSQEMDIQSESQSREFHSQQSFEKLKPQNARYNQKRVEVAQETVRFIPSVLAQFPAAQQQSSLYLGEEFSLAGITCPGFTLPDLDPEAGRRGCRIKVINGDTFDTAIAMGRNVVVLNMANPQVGGGGWKMGAMAQEEELCYRSTLSFKLHRAYYPLSDLAGIYTPAIVVFRTSHSDGHKLYPPSTKYKTLSVISVAAIRDPPLINSTPPDYRRPTDRNLMLEKIRLILRIAVTEGHRKIVLGALGCGAFHNPPEKVVECFLRVFREPEFAGGWWREVVFAVLDTEKDEENKGPNGNGNFGLFFRGLHGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMS5</accession>
    <name>A0A2T6ZMS5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1194469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000174">
        <property type="protein sequence ID" value="PUU76799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMS5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMS5"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="43"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="569" mass="64506" checksum="B13F7E996D7B25B0" modified="2018-07-18" version="1">MDSSMVSKMDSIIRLFRSEEILVYEPGDVEYERSVAVANLLYRFSRPHCVVQPTHSADVQIIVKQAKKRDIKITIKNGGHSYAGFSTTDSGILLDLVKMKKVSLDIESETVTLQGGALWGHAYKKLVSGRYDGYIINGGRCPTVGVSGFILGGGLGPFTRSLGMGCDSLKEATIVTADGREVTVKDSGNPKSDEDRLFWALRGAGGGNFGVVVGLKMSVQRLQNPEGDVVAGRYTWSPKPEDMDGFMTTMKDFYTTNWEPRMTIDSSWLCDLQHTTGELAVRFIVYYDGTKDSFDNIIDRSIQHPELKKQLKRRSLPEKSTRFLHETLVAQWSEEIAKSFPSNRSYTIYSSFIFKNNLKTCEGVTTIIREEMKAFRELFPGEQGLLQVTWIHSGGEASKKKREATAFRWRDSVYHTYIMMQWDDKWLERDMRGFLQRFKEKLRPFSMMGRAAFINFPDVVLPQNIHERAYFGNNYQELQRIKKIWDKDNFFSWAQGVQLPKPKKGTPVSDSTAPRSIKMEEEYDEDVAGELEVNEQALTDTIASEQWETGIPGRNEFEGGVVGLTDLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMZ1</accession>
    <name>A0A2T6ZMZ1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMZ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMZ1"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="359"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="761" mass="86456" checksum="FD18CDC9E2F1685B" modified="2018-07-18" version="1">MPRYDDPTPEDQWLYYFKRGEKILKEAEARKGQKRLNKPQRWQFIFEYNLKNRGTTGEVGSAGSGGRMVGINIAYNEHPPCIVPFATLEKKFIDDLRLEIAHRGSYIMLRAVVNPIKYVSVTTIAEDESGEVELVQIYNQDDRRSPANVMPEGQVFIVKEPYFKTTSEGGTSIRVDHVSDIIFLDGEDERIPEKWRPRIKLLARGSLDWKDDGNRFYKGKQYFEATQCYTKGLETVEPGSALDIVLLLNRAQAYLELGYNEKALADAKKALYYEPLNQKALYRSALACYEDGDYESTKTQLVKLLKEFPENKDAKEKLLRTFRRLQEQRTGEYEFLKMRNEVKEWGDKRGKLDCAEYVGPVRIGDAGGKGRGLFTTRDVKFGDLLLCSKAFNVCHKEVANARIDILFNLKAKKGQAGTHSQLVQELIQVLYHNPKKAKGFYELHSGDYQRVRGEMVDGLPVVDSHLVMRIMLKNSFGCQRLSFVDGRPGDLFEEKTEVEKMVTEMSPSGTTGGSGIWIMPSYINHSCWPNSIRSFLGNLLIVRAARDIPAGEEITMTYIDNESGVQERQKASYSGWDFSCECTLCEIEAAESQEVQSKRQSLVEKALKFKVYLNQSVQKTNSRIAPMITLIKGIEATYSKPEFIHPRVRLLSPTNILQTFLVRAQRPPDVFLLARQALNGLGFKFTTKGGKVVIERYGYMSYPVMELFMHAITAEAMMGDLWTATLWRNAAVDVYEVLAGERESFINAFGGVLLEAGVPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN95</accession>
    <name>A0A2T6ZN95_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_988727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN95"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN95"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="307" mass="34108" checksum="695120A2687B8593" modified="2018-07-18" version="1" fragment="single">FVQFLGWFEIPKTLYIVMEYLPEGDLTKHLSSPLPLETVQTISKQILEGLKVMHEKGMAHRDLKPANILVVSTSPCRVKLGDFGISKRISPQGNIAFQTHVGTQSYCAPEVLGLDPCSETSMYTNSVDIWSLGCVIYELLVGARLFASVTQVSRYLHGKDPFPEFTLKRLSIPVDNAGISLLKSMLTIQPEGRPTAASALGHAWLAGLERHKTYVGEGNNGHKMVEVWINCQELGRDAFGEAYKQVSRTTGNHRAIKRIDKRRLPPTLSNSSELHMTDILAKVCPLFPRGFAPVYCPSMISLLWSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNG4</accession>
    <name>A0A2T6ZNG4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1147415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000166">
        <property type="protein sequence ID" value="PUU77028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNG4"/>
    <dbReference type="OrthoDB" id="5423652at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="235" mass="26327" checksum="5CBAB3C46644FD19" modified="2018-07-18" version="1">MSRIFIKRLYPTPLLAVKPSPRFRFPTRSFNSFTNIYNSTTPGTAQNDEGSGNDNPRKLWTTQNENHLIGRIYKLEDHAHKSDDRFINSVKDSAALKVDVTKAIGEISSKIEVRFSKMDATMAKLSAEHKSDMAKLSTDMAKIYFAHKSDMAKLSAEHKSDMAQLSMDMAKIYFAHKSDMAKLSAEHKSDMAKLSTDIGKNYAEHKSDMGKIYVELKTDIGELKSKVEKISAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNZ6</accession>
    <name>A0A2T6ZNZ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1101976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNZ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNZ6"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF120">
        <property type="entry name" value="HETEROGLYCAN GLUCOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="122"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="557"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="737" mass="84211" checksum="D72318B853107809" modified="2018-07-18" version="1">MAKGWGEQGGKELLKKSTLMNYFNFDNMTYSSVYGQGPLDEREPLYHSEPFWLELNGLPNYKSQVATFVDNYSQICVDFCVNHAGEINVGTRFGPLQYFVFADDSVAEIIQLYSSIIGRARLKPRYVLGHHQGCYGYDTRNKVLKAAYGYVKRDIPLDGMHIDVDLQDNYRTFTIDSERRFARPKEMFDELRELGIKSCTNITPVINLNPSDTYNTLQEGHKYGHFIMDKRYDDGNGVVPVHKVEYICYERGVKLFIDPVNEKGQFPGSEYDFTKYYNNPKEAYRGGVGYGGTLGAPGHYPNLNNANTRKWWGEQYKYIFDQGLEFIWQDMTTPAIAKEYGDMKGLPFRLMVESDCWSGKDDSPEQMKPAIEIWSLYSYNLHKATYEGLNKLKSRKNKRNFIIGRGSYAGANKWAGLWTGDNASTWDHLHISVNQVLSLGISGNEIVGTDVGGFMPAGGFNKSAGGRWAEPELLIRWYCAYSMLPWFRNHYHGKRGMKLFQEPYAFTDHFNSNPSGVPEKERYLWLSVEPICRYYVKLRYSLLQLLYDAMFEHQFNGLPIARSLVITDSEDSSLLGEQDWVLDNEYMVRNDLLVCPVMHRQSVAGGHRSIYLPQPDSWYKFNLRIDNDCPRHHGVPLEKRIPGGSKFEVDAHIASEPAFLANITPMFVREGTSPSSPKMAMILRSLGPYDTAGGIIPQIEVRQYTDHKPGKPNPIFIHLYPGQKTNVRHNAPALPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPB7</accession>
    <name>A0A2T6ZPB7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1086410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPB7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPB7"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="72" mass="7913" checksum="8CC148661F78BA8E" modified="2018-07-18" version="1">MSTRPSKQQAAREVIDILHEISTLLSTHLDRTTLSLCVSLVENGVHPQALAAVIKELRRESGQLRSGEVQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPS5</accession>
    <name>A0A2T6ZPS5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribokinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_986632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000151">
        <property type="protein sequence ID" value="PUU77489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPS5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPS5"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="1">
        <location>
            <begin position="187"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="365" mass="39993" checksum="FEDD504FAB3F47E2" modified="2018-07-18" version="1">MDTPDSISQWNAPAKNVDFTTFGMFIIDEIHFGEGKDDMVDNIIGGAGTYGVIGARLFSPGPRAKAIGWIVDAGNDFPEEIRQDLIGLGTDLTLREDQGRRTTRGWNKYGPGDYRAFKYLTPKKRLEVNDLVEEGLFTAKTIHLICTPVRADNVCSGLYKALQDRLLRPIPLVIWEPVPDSCHPAHRMEMYKVLEMVHIISPNHDELAGYYGVEDPLDKNNPDTTESLAGKIVAAGIGKQGNGAIVVRAGKLGCLVGCRKHAPIWLPPYYPPTEVGGNNPKVIDPTGGGNAFIGGMSISIARNGSAKFVLAAAMGTVAASFAIEQVGMPKLEMVNGEERWNEVRVKERMEEYRKRVEELGISLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ06</accession>
    <name>A0A2T6ZQ06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_899623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ06"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ06"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03524">
        <property type="entry name" value="RPA2_OBF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="223" mass="26137" checksum="48B12211F812BF95" modified="2018-07-18" version="1" fragment="single">MTATPSAERPSFYPRFLFPHSLTYNAWARLTAKDIHEGLHRRRGFEGQDVWFYSNHPIRWVRVVGVVVVYDDMEKMVSITVDDGSGYLMDLVVWKGEPPTGRKPKFSFDDLKEVGLHSIIKAKGSLGEFRGNKQLLLRRIAVLHDTNDEVDAWTETIKFKKNVLSKPWHLTEVFINEERGRVMGAIEEEERKKEKKRRKDEQTLRRKEKELEKAGREEKRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQF4</accession>
    <name>A0A2T6ZQF4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQF4"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="547" mass="60887" checksum="00D81385736C7CF7" modified="2018-07-18" version="1">MPKSEYGKDSVATRPLFFDRVNEGFPITSTAPFFQLPIELLNDITTYLGTEDLKSLALVDRNCRQLARSVQFCTVTLDYSVQKHSLVAALDEEAQGRSVNNGWLPQPSIGACVRRLIVATEPGHFAEAHNIAEPRDTEDLRKIWNGYFGVYTVQIGSAIAGAFLNLEELSLQDGNVAPKHLLGAIPASPIRTLKLGRTALEADDPIPIPSGGARWGVESLELEVIRDLNSSSSQCTANFCKSVLEATSENLERLVWRGHFKDQQSFGQPISFPRLRTLSLSLISISDDTVLGSFFPSGDTSTLRALSVDIRTERVRTFLSTLGQIKTLQSLYCHSFAIAKDPDISFIASNSQLKSLALSPYTNEYLTTTLLPTLTKFTSLTSLSLISQSPLIDPSSLTYISKIKSLTQLWLSAGKQSGWAVVDWEIDHDTLLTMLSPLQGLRRIAFTRDTYRSKDGVPPIEYYYEYRILPEALQPVLGGDDLDAAWEEWHRNRMVDVARRYFGAFKRLRWLLVGNYPIGVMDGKPVVESGARDGCEGVLRKWWGLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQL5</accession>
    <name>A0A2T6ZQL5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1127861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQL5"/>
    <dbReference type="OrthoDB" id="5345498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015718397" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="544" mass="60693" checksum="FC5AAAC867D321C9" modified="2018-07-18" version="1">MSIHLPLHLALLLIPYLDPSDIARARQVCKSWYPVFSSNTLAQAALRIHYPLCYEIRAPSRPIDSSVFNRVGRRYAALKSGIPQQELRIPITKTRRNECVWTFSENLIVAQVRHHPVIQLALVYLDTSGGTRRIRNGKVTVPAKGETSVAVKVCRDILAVERAEERVTNPARSNWVAVVNFFRLSLEGEDAIAATQVSTINTFEFRYIDYSHQITSDHSGKYYAAYSRAEASRSGGMLCVWDIETGRMVRRLPAASLAGIVMITDVVVVAKHGSEGQQHVVVAGNDKRNNNANRWGRYPGEWGYLSSFKAFPIEDDSAEAEWNGFVGRTKAAAPRESNILATTFKVPRFPHGISPVDALDTPGYESEDVGLALWELEDRSGKATSYYHKLSPETYPKPTTDASLAADLEYRLPEEASGFPAPFTVKGRAGLSFTMDFTGRNEDFEGTRLMLYQLRIQGFYPSDIPGVMERDWESCLKIGGATEQTRGFYSANRNVSYTNMLPAMKVIEDEMAIAFLKLAQNGMDLVVAIWDEPYEGKVLDGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQV7</accession>
    <name>A0A2T6ZQV7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_985531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000139">
        <property type="protein sequence ID" value="PUU77814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQV7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQV7"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015443911" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="246"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="483" mass="53529" checksum="D1AB2454F68CA489" modified="2018-07-18" version="1">MASLLLLSSLALLALAAPPLEDSNVLRSRAVSDTLADLLNNLQDGVSAKDIKQSILPDYWSIPETKAITKALGLNETGIRALPLEFLNIPGYANYTSQGWNLRIHGMSYKQALSDPGVVSNRTLDKAANKFLPDFDVSQLQPHEQDNARNLTSAVLSLPQEGEGLSFTLDVSEGQDFNSGWTGVVEWAKTTDSRGEIDGFVQLPTNNQDDLPDGNATNAKVVQLNVHTNGTNTGNATAYLVPRDGITIVSDIDDILRITKIYEPKEGLLNSFARDFVPWMNMPGIFANWTRQHPDSPYHFHYLTTTPEQATRVYMDFIYKTYPLGSFDTRSLNFTTVDQTFSVRKTLLNKIFQTFPNRKFILIGDTTNNDVMNDYPELVSTFPGQVQCILLRNTTATDPGDKFPYNTKGFQSLKQEQYMFFTTSDDLIGLDFGNGDCRNASAQMGTVDFSWQGLPLKKSAAGGRVRGNTWAALIVMVAFVVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR90</accession>
    <name>A0A2T6ZR90_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_984537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000132">
        <property type="protein sequence ID" value="PUU78010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR90"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR90"/>
    <dbReference type="OrthoDB" id="3344688at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11751" checksum="141AC41FC3869240" modified="2018-07-18" version="1" fragment="single">LSQSRYIDMILKRFGFENCYTVSTPLEPGSKLVSNPTNTDTEDEGLYRSILGSIMYLILSLKRLLYYISKTRDHGLHFGPFTTTDQATPYIFSDAEWAGDKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRH4</accession>
    <name>A0A2T6ZRH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_948189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRH4"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11012:SF30">
        <property type="entry name" value="PROTEIN KINASE-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="89"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="334" mass="38129" checksum="761BB261BE312F44" modified="2018-07-18" version="1" fragment="single">LTSLWSNYGYIHRVTLTTPSNPTPTPCILKHIRPPSASSCHATESHLRKLISYRVERYFYTNLSRLLPSDTTKVASRYDVAGEHIDDALLLEDLTRGFPLRAPHTLPLSKTQSVIRWLAGFHATFWNHTDIPLIPSPNEVREPDTAEGVWAQGGYWYLATRSEEYASLEDSQEEEYAWLTPYALPVAEKLKTETLGRTLLHGDVKGANILFSKTVPRDDAQQEVKCALYDFQYIGSGLGVVDLAYFLGTTVDERDLRGSEKEEGLLRLYFEEVESVLKERGMVMGGYTWEALVQQWEWALVDWMRFMAGWGCWGNSGWVERRAKEICARWGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRM1</accession>
    <name>A0A2T6ZRM1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1084818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRM1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="160" mass="17398" checksum="F9385C12803BCB23" modified="2018-07-18" version="1">MAFGCLAEEGGGGGYRYVVWDFVRGGPFNYLVWPSEGVIFSDFLGRETRGIYLVSLRAKLCYGDIEGSENGRGVISPLCFMTSKESPPFTCSRVSSPSEGLYLRLWLFLVRSATVIDKSKGELIKNAPGDAHALGDTFIRYPAIGGLQAQYTSCPCRGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRU1</accession>
    <name>A0A2T6ZRU1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pre-mRNA-splicing factor of RES complex-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1084584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRU1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRU1"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="253" mass="28421" checksum="23C9D62D7EFDF0CE" modified="2018-07-18" version="1">MTRAVSRTTKSNWTSVDNNDAAAADAIISAKNPENPEDQPAIVEGKDEKPTTIQKMSSGAHAGLQTAAQVAAQLERQRKAEAARFAAEDPEISGKGQETIYRDASGRIINVVMARAEARKKLEEEEAKQRKLEEHLKGDVQLVQKAERKKELEDAKYTPMARYADDKELNEELKERDRWNDPAMAFLSSKKKGVSKTGRPLYQGAAPPNRYGILPGHRWDGVDRGNGWEKKWFQAQNARKNRAQIEHDMEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS74</accession>
    <name>A0A2T6ZS74_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC-2 type transporter-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1126916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000122">
        <property type="protein sequence ID" value="PUU78335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS74"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC-2 type transporter transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="CDR ABC transporter" evidence="8">
        <location>
            <begin position="77"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27957" checksum="9F0E91E2F5BA2673" modified="2018-07-18" version="1">MFSALCPTLDDAIRFSEMALNICIIYACYVTPKTQLLHDAIWFGWLFHLNPLGYLFEVILANEFTGRTIKCAGSMIVPRGEGYDNFPQYQGCVISSGTLGNLNIPGDEFIEAQYSYTSAHLWAIPSKMTDLRNRIFTAYFVVMFPPAIINSAVPKFFENRMIWEARELSSRIYGWIQFYTTHAVAEIPSTVVTTVIYYLLEGVTNNNPILPVIFVVFGLFKDLIIPHRDVPDVFYYTLYYLSPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS91</accession>
    <name>A0A2T6ZS91_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spo7-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1084266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS91"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS91"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="446" mass="49352" checksum="CBA1597CFE2C57C5" modified="2018-07-18" version="1">MTSRGTDNPELDLAVKGSLPSTSSLPLLPPSASSPLSSASSPATHPRPPLPLANPLDSAPCSPPQVYLNLLILEASLRSQYLHHLARRRKSTLFLLLLFLWVGFFFYRLFVLGRSPYYYLSLLEKFGFGGGVVTAFLYHATGYYHRSIVEPRQFVCVANRGLRGFNVKLVKVPLSYREWVLWWWDWYTFSPPPASARLPPARRTSTAKRRTSSVHARRPAPPIHTHGHTTSISATMAGGKSSSLLTPHLEEAMEDDDNDEVEGYLPGGLHLKIVILPKRFTPDFRERWEDYRAEYWEHENEVRANHRKELYRWHKSKSKSSTPPPPPPQLDPGVTSVRARRNSASRPPSVSSRAGTPEPDSAAAPAVTRQRKGSLVAKRRPNLAPGLRPAGAASGEISDSGSTTSALEETRRRRSESPVTDRSSSSTAGSAKKKASGRGRGKGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSE5</accession>
    <name>A0A2T6ZSE5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1193405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSE5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="142" mass="13449" checksum="60569344436B8004" modified="2018-07-18" version="1">MSPRGGGGHGGGHGGGGHGGGGGGGRGGGGGGSRSSSPHRAANPAPAPAPPPPASGGPGSSLGTSAAAGAAGGLAGGLAGGMIGSSIANHHYDEHHRNQDTGTGNYRGNETVSSFAMQSPVCDVGNVALWLVAMWVVFGYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSR0</accession>
    <name>A0A2T6ZSR0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1142373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSR0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSR0"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="164"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="38425" checksum="43DAB1AD3477B9C8" modified="2018-07-18" version="1">MNEEFFGEKRTSLGESVRTFDAFPKTRATYTTRTPRGGAITLLLLLTSAYLTLTELRNYLTGNESQTFLVEPSIGHEMQINLDITVAMPCSNLHVNVQDAMQDRILAGELLAREDVRFDDGGAHKLFQQPGGGGAAEREQHGGLFSSLSGGGGAGAGAGSGSGSSCRIYGSMGVNRVQGDFHITAKGHGYWEDGAHVDHQSFNFSHVITELSFGDYYPKLVNPLDGVVSKTDQNFYKFQYFLSIVPTTYESQTSGKSLLTNQYAVTEQSRKISSHAVPGIFFKYDIEPISLTISDRRTALLAFVVRLVNIISGILVGGGWAYGLFGTLAGYFRRQKRRTDGMLNGRALGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSR7</accession>
    <name>A0A2T6ZSR7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1101311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSR7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSR7"/>
    <dbReference type="OrthoDB" id="5351478at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="605" mass="67516" checksum="F80BAB553A8C1D9D" modified="2018-07-18" version="1">MQFLLSRPPSIQENQRVTAILSSTGLLVRSGYGIEYPLVTHAFLDYYSQRSFLWSQTPAETYLDVEKELELEENSFLEAIWAPLTHVNTASTFSSFPVHAFARYASIATMQTPQLKVGLVKKICTQILKRFEELKEKAVWGGGIDEKALVVALFASGWLCEYYAEGDAIAQFKKQVEISTELIGIGKDIGGCLEKLSVLGEQCAVQRSVAVQDGMADGLKFRKPWAGFLMEYQDPKKKKKEEDDAQWGTLAKDFIRLQSIAVQVPLIERFNDGMRLSLKSELSNIYSEVDKIFRGSPLHVFLSVYPWIPGSLHNSLPSQLPKLSSKQFVAYPGLLQLHQARFDPPSTLPILQNLLTATRTHSRRDLELPTHILLAKQTFTLRSLTATLSHWEYVATLLSPRLHLLPHHLPTLLHITFLAALTHTHLRAWEFALSTFNVALSLAVYLADTTTQYCILRKLSAIKRESGLGLPVAETLLRALDLSYAGTSQPAFIDECGVLTQRILSAARSGKAGESMENVVERLAMKRGWAVSEMKNFVEDVITLEAKIVRGGLEMGAGGAQTERELKGMYAEAEKMLLAKRKRDKAESVVGSSITNYRAIETVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSW2</accession>
    <name>A0A2T6ZSW2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1101254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSW2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSW2"/>
    <dbReference type="OrthoDB" id="5386574at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021582">
        <property type="entry name" value="Aim21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="84208" checksum="4632F7CD4074286A" modified="2018-07-18" version="1">MRSPPSVPPRPSRSAVPDIPPRPSSKSRSKSPFEQEGPALTTIPPTTELHAPVARPPAPKPTESGSSITTSTTLKNDSGIPQIGRRVPMYPNAGDVQAPSPAATPGAGKKSHVYREEWEMDEGAYGNGTPKGINPYTRSSTDLNQSVAQSPDLGAANDASTPVPDEEIGYLASEQYARVISPQPTGTSTAGQDSDDAPVSLYGIVANSSTSIDEKDKEISIHLDALPHHGGVYHHHHHHDSRAGTRPGTRPGSALGMMGEDEEEEEEREHPILASDEVQKRGGEFMLPAVSPPLPPRRPGSMPNTRPHSVAPTGPCSDADDDEDGDIEPADLSSNTGFELRESLIALQPGEETEPLFPEDEDEDAGGCATGAVDKVQEKPKRPGMPPSMGSSYRFPSKDIWEEAPDHAQLQAIVSSPPTADVETQDDSREEEKPAERTRDYRHEVQSEGPDEHLDRLLKRGKKGEESVGSGDRNGVKRFPSNDIWEDVPPSLQLSTTVTPSNDSQEGNTNEHESRATTTGATRLDDKITSIPEEEDDTRPTAGAPIEMSSTTEPASGNTPLISSKPKPAIPPRTGGIGGKIAALKAGFMNDLDQRLKLGPQAPKQEEKPAGEDDKPTEVLGDVRKSRAKGPRGRKLPTAKETETKTEAKAEPATFKMEIVGVWTVWSMDDKGVSVGEESAISSTGGSETGTKSEPKAEDRKDAAPTPSATTLPGVTGTGQQAAPVIDKDVDASVTSPASRTEEEKREDEIPTVIPGGQHPEDAIETSEVGNGGVGEAKQEDVGNTAGDQKVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT57</accession>
    <name>A0A2T6ZT57_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_981854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000110">
        <property type="protein sequence ID" value="PUU78679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT57"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT57"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="235" mass="25726" checksum="3AFBA873089E9961" modified="2018-07-18" version="1">MLLPRISTTGILPSLRNIGASGCGSNSGILQQVRHATHKASKAANGSSNTAGKRLGAKKTAGEKVVPGMIIYRQRGTLWFPGENAGIGRDHTIFALRTGYVRYYRDSGPKKRKSIGVALTPDQPLPRPPNAARTRRLWFEPVPLVEKEDVSVPQGTPLTQEDWAKVVPGSYIPRPDNWRIGKVMGPVVRKRSVFEGFERSAKRREARMKKLALKGGKTKKAKAKAKARAKKARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU42</accession>
    <name>A0A2T6ZU42_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU42"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015674437" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16438" checksum="8F8EF1DBA7F846FC" modified="2018-07-18" version="1">MSLSRTRVLTLLELLLSSSTACTRVPPTLKVLTVYRTTSAPNDEYDHAQAESLALGSSINVLEHTKNLCSSMIMPITSPYPTHLLFRSYHTLVCSNVVCLSRVHSAIYYPFNSQAETGQWLNLLSLMLKAAYDSVRFINYLTIANLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUM5</accession>
    <name>A0A2T6ZUM5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUM5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="183" mass="21169" checksum="296E3EF752D5DC15" modified="2018-07-18" version="1">MQAPISLPLPFFLGTIRNLPRLIIESDVFFSFSSSNITTHFTLIRIVLYCTIIISYRIVHRGRREAEKSFIYYMPSIYLSTREGCCMWIKLGIDNTQEYEGCGIICFCVTVIVPTGRVLDSGKKYRYPHTGIREIYGQSSVHICARKQTKSYPQCSSTWQCQYFLPRTSACAVLYQPRLQFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVQ6</accession>
    <name>A0A2T6ZVQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1046696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVQ6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="32110" checksum="076A219D1CFFB6DF" modified="2018-07-18" version="1">MDVDMRLMEALGGHHGHHLQNPAPTQTESPELVSAVSELTDLLRLISQVPQGSENSSYPNGHLSQNHSNGSLTSQLATTLQLGLNDHALLQSLRLSDESFQEILGCSLSVAVSPQECLWNQDSTQNNSHLQGSESSGIGGNSHEEALAEMQRTIVELSQPATRANSPPPSIHGRGSFSEYSETSPAGCPNGLAREDSQSMSPAPHRSDSQDLEMSPAMDVQTPEFLARNSMGRVRNSVSSSSRARQDDPYEDPAKVAERERVRGENRVRKKRWRESNQDRSKCAPLPCFQVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWD4</accession>
    <name>A0A2T6ZWD4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1124648</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZWD4"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="974"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1208"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1469"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="692"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU79788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1697" mass="186969" checksum="74AE25128975DA9E" modified="2018-07-18" version="1">MLPSPAFHRRQSDQTGARAVAEPTLLSKLFHPSNPNTPGLHHFQHHQPNLQRPNISQEGLPTRPMYRAQPFSAAVPTPSQHTYQENLLRRKTPSGTLPAAYDAAPMEWSTRPTKHILLPTPQSNSPQVHSDPQLTRHLSWDNSIGQGVRPWDGGGELRSADMAGGGGGNIAPTVWVTQPSSQPSLDDNLDPYVRQFLLQQNQMVPPISDNIYMGGRPCGFQPFYNPITAPTASCEDLNDLMGCGNYNPVPRDSNWYAHYGAWGNGNTTPTQLPQAPIYYVNSVYTPSPHQMNGAPLWTSQQPSAIDSVSVSTFPPHITSPYPLNSPSVNTPEVQLQHLQLDGPSPNLAHHDTTSPQFRDKVLAWAHGVYVDLLAALQAQQRQSEGNPQEANRSRTQLKVGLFPRPPVQPPANNRRSDNTRAQQLISTPSPMPSPQNIMPGGFIVNREATDRRKRMRPGVGQEQNHPEIGTSSSHSSALVFENNDGYNFSRVDGVHAHDGNDNPSEHNAHGIWPSGEQSYGGKQPRDCYSAGSLHRASSGIGNNAAHMLNITPPGGFGVINQRPSPATASAVAALDMLNELCANSNWIWLDGMLLGGCLAYGLGDLTRAIEWYSKILEVDHGHVEALSNLAATLLSLNRRQEAEQYWIRAVKRRPSYFEAVEHLVGLLCGEHRGKEAVDIINFVQSKLRRPSRLNGRNPSLSSSGSSDESASTSLSASPELKFDHDMEESHAKFPSAKSIVYHGSSEFLIPSSDNGRMLALIHAKGNMLYTLGDNAGAAKAFEDAVLLGAGMQRGGIRGLINKILAVLRSAADSVCISEKLSTADPGPVLLTPEKAVLTTKFVFPPTGELPGLRDIPSTAAKRAAISTASNSLLSLAKIFQDGMSSGHGAGAGGPKSGADVKDILALYYLSLSLHPSPSTANNVGILLASVQQVSALTTAPAPIIQRPPGVGQGSGINLALQYYYYGLSLDPRHAHLYTNLGSLLKDINQLNAAIKMYEQAVVCDPTFDIALANLANAVKDQGRIGDAIGFYRRAVKASPEFAEAVCGLANALNSVCDWKGRGGIVRDRGNRDRWHVDDNGRLIDAKGVGIESSGWMKRVVEIVEKQLVDGEHWGKGVLAVSEVADTLLRELEKADGARWSEERRRSLRRRVEGWVGKQFEGAKVIRLIERASRRTVWRWYQEKYVQGVEKPLSEYSRPTVPLSLSTPSAPTVLPFHTFTCPLSAKQVRMVSQRNGLRISCSTLRAPWLPPHVFPPPAPPAPYLKIGYVSSDFNNHPLAHLMQSVFGLHDPARAKAYCYATTASDNSEHRKQIERESPVFHDAHSWGPDRLVQQIVNDGIHILINLNGFTRGARNEIFAARPAPIQMSFMGFAGTLGAEWCDYLYADSTAIPAETLRPCRRNVDLEDEGHEDTTNDNGEWVYSENIIFAKYSFFCCDHRQSAPDSKSRQLSWEEEQTRRWAKRKELFPQLKPDNVILGNFNQLYKIEPTTFRTWLRILSRVPKAILWLLRFPDLGEGNLKALAVAWAGEEVASRIIFTDVAPKLQHISRAQVCDIFLDTPECNAHTTAADVLWSGTPLLTFPRHKHKMCSRIAASILRAAVPQTLEGKRMANSLIVGSEEGYEDRAVALVSNLVYDNDEGRGIGELGAIRQVLFEHRWRSALFDTKRWVRDLEDAYHEAWRRWVSGKGGISISRRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWF4</accession>
    <name>A0A2T6ZWF4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1022830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWF4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWF4"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="14"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="129"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU79806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="339" mass="36408" checksum="D2A92C165D072510" modified="2018-07-18" version="1">MAGQSKEAPLPSWGYALAGATGAVLANAAVYPLDIVKTKLQVQVKRERKNTEKSLENGDVSKCDEEEEGEIYTSALDAIQKIIAKSGVNGLYTGMVGSLIGVASTNFAYFYWYTLVRNFYLSKSTAGAPSTAIELSLGAVAGALAQLFTIPVAVVTTRQQTRPYSAKPLGLFATAQEVISEDGVSGLWRGLKASLVLVVNPAITYGCYQRLKQILFNGRDRLSPGEAFLLGALSKSLATLATQPLIVAKVGLQSAPPPGRKAYKSFGEVMKVIVEKEGTLGLFKGIGPQLVKGLLVQGVLMMSKERMELIFILLFRWSKKMRAERLAKVASALPLVVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWK9</accession>
    <name>A0A2T6ZWK9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_977345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000079">
        <property type="protein sequence ID" value="PUU79863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWK9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWK9"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="428" mass="47323" checksum="5783EF62FDA0F947" modified="2018-07-18" version="1">MECYDINEGDFSGCGPLGWAARNGHERVVEILLRREEIRPDSRDNYHQTPLSCAAENGHEGVVKILLGREEVNPDKPDIDGRTPLSWATLFKHDRVVKTLLGREEVNPNKPDRLGKTPLLYAAMCGHEAVMKTLLGREEVKPDKPVEDGQTPLSHAAQCGYEGVVKILLGREEVNPDKPDKWGAVPLSRAAGRGHEGVVKILLEREEVNPDKPDEDGRTPLSYAAQCGHEGVAKILLGREEVNPDKPGISGQTPLSHAAGRGHEGVVKILLGREEVNPDKPDKHVGQTPFSYAAQNGHEGVVKILHGREEVNPDKPDNDGRTPLSYAAWNGHEGVVEILLGREEVKPDKPDNDDRTPLSHVARNGHEGVAKILLGREEVNPDMPDYRGRTPFWYAAQYGHERVVVLLQSRKTVSSSSDISPRKRRRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWM8</accession>
    <name>A0A2T6ZWM8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1045758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWM8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWM8"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043545">
        <property type="term" value="P:molybdopterin cofactor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="46"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="193"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="639" mass="71398" checksum="BE79D4AC7960F09E" modified="2018-07-18" version="1">MSPPKTSPSFRSRTFKRKAVPKLEPGYNPNIEKLRIKEYPQLKDQTYLDHSGTTLYAESLLTVISADLRENLYGNPHSENPSSKLSASKVTAVRLQVLALFKADPAKYDVIFCANTTAGVKLVADAFAGHEQEEGEKGKGSFKYKFHKDCHTSLIGPRGMAGSAECFWGDEEVEAWLDSPEEDEEGEEGRLGLFAWPGQSNFSGRRLPIHAWSSKLRETRGGRFYSLFDAAALVMTSPLDLSDADASPDFIVCSFYKLFGYPDLGALIVRRESAGVLQHRRYFGGGTVGQLMASIDHVKLWYHKDPHEHLEDGTCAFHSIIALGHAIDTHKRLYESFEKISAHTASLAAVLASMMGELTHRSTGQKLVEIYTEGKYGDPKQQGPVVTFNLRDSRGEPISYLAVEAAASARNIHVRSGGHCNPGGVQHYCRLGKEKMMTIFNAGKMCGDEQDVIDGKHIGALRASLGAMSTLEDVVTFVDFLREEYVSKPLSLEEKRRILLQEREKDVEEVKRVMKKYGTVLSGSRTGTLLCFWADPVNLDEALPMDARLASNSFASLRDFFTGGRSLAGLLKLFTLTYWAFFSFLFGRTNTYGFFIWTFFILCFILFSFFGVGQTTSRPDTPTTRTDADWLIFYDEMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWN7</accession>
    <name>A0A2T6ZWN7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWN7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWN7"/>
    <dbReference type="OrthoDB" id="565552at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.70:FF:000001">
        <property type="entry name" value="NifU-like protein 4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="275" mass="30704" checksum="A63A0CCB84D95A93" modified="2018-07-18" version="1">MSSRKLLTRLFLQSRPHFVLPPPVRQFHTLYRPTVPRTAHILRAPKRTLFIQTESTPNPSALKFIPGLPVLPEGCQSQEYIDGRETHSSPLARKLFAVDGVRSVFYGPDFITITKDEEAQWALLKAEVYSLITEALNSGEPVVLEGTMESSDTKREEGDSEVVGMIKELLETRIRPAIQEDGGDIEYRGFENGVVKLKLRGACRTCDSSTVTLKNGIESMLMHYIEEVQSVEQIMDPEEEVAVREFERFEENLKKARGPGAIASTGKGGLDNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX89</accession>
    <name>A0A2T6ZX89_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport protein Avl9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1080254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX89"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="8"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="815"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="958" mass="106991" checksum="607463FBA38616AC" modified="2018-07-18" version="1">MDKPQRSPVVTIVGFHHARGPEVETWIGLEREDDISDWPLLPFLALADGAHASEEDFSYFTLKHTTPTGPTTLFGISCTRQLDASQLADKPADVTRSTVQKAVVVIADSPTFFFSHLKQQLSAVTTAWFAQRNFEDLDIIRKFQESLKTSIRDYETDRSRDQFVGLSLREFVYEFKHQTLILFKCALLQPKMLFFGSSCERLCMTQFSLLSLIPGLLRNLEDCGDPDMNTYESKLKKPTSVKTSDRKSLLTFMGLPLQIFGKGSLFGPYTPLQQLDVLADFGTKSYVVGSTNSLLLQQRDRYSDILINLDDKSINITSSSLRAALSLSAADRRWIDVLVQSVSESWDESDPTRPKTMGFTGSEDYIRLQFEEYILSMVSSVKYHLFLEKHAGSESNLLLPDIDGDPANDFQMDWVDAWKKTENFRIFQKFTDSELFDLVPPKHVMAGGLTMEDVQRRILQQMQELRLEEKVQNSKEALAKTLATGRVNVSTVFNNLSKNVEKFREQRKSQSQDSMQKLSIETGEKPSTDSNPSTAAPSTVVSPVLADASSRAGAYFSSWAAWAGEKRKKFVQNPTSPVKSDGGDRPLPNPPPADSLGSFEEAIFDSRSRAVYASSSGRSSPQRASVSSNATPANMVIKDLDKEKAIGLGIVDAGLQSPPVPPKPFAEEKKEPEPIVEEKKMAPPSQPTPAPAPAPAPASIAEEGKRASFAEKRSEPVVREKSPIKREEKKAIPAQEKEAPVVEERKPPPITRRKTERAIPNETKDEIEDKEAQWRERITRRMERARTMEQGEDRREERKARRTEEAAPQTQERAPTPTTPGRVPTPTTPSRAPVRPIGSRPMPSPSRVTPEPTNVNTGPSRLEPKRTSSPVFDPARVARQHTRAESTASILNREKPRVDPSRPSASGLPADPRPKRFSLPRDEARNEARKSLSNSNTPIVDNPSRSAFAARRAMFEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXH6</accession>
    <name>A0A2T6ZXH6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXH6"/>
    <dbReference type="OrthoDB" id="5467127at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="238" mass="26558" checksum="6DA6D763E37F388B" modified="2018-07-18" version="1">MPNKSWVAVLRHYTLQELSEAACQYVEDGEHPRQFIGILRDIQGLNVTPDGTGQIGLIDDNQVNAWLRLSQCSTLTVACFLHRAAVATPDGRDPVRPNTPLVGHSRNYLFPGQFDIAEFYTESESDSDEEDDMERHARRRRAFPRSHNSWQRRILSNDRRVIRFQTYSQELISHARVRQGPAYMSRYAGQDVPMVALSPGIPPPRCEVSVQDAIEEGADDNGGGNGGNGGNRGNRGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXP0</accession>
    <name>A0A2T6ZXP0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">And other transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1113966</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXP0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXP0"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="113"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="644" mass="71639" checksum="FBB4DCE6BEE1880D" modified="2018-07-18" version="1">MKSGAALCGLFFSRLSLVRESGERVNTVVRSNPLAGLQRAELQELGRKFVVDKELGTKYEGLFQRAAMLAQDPLSFREPNSEFQTNRGLGAERDALERELTHKWDQPKRLYALVITCSLGAVVQGWDETAINGANTFYQDAFGITKNKWLYGLVNSAPYFCCALIGCWLTEPLNHYCGRRGAIFISCVISSVTCLGQAFTQTWQQMLVARFLLGLGIGPKSATIPVYASECTPPTIRGGLVMMWQMWTAFGIMLGLLFNVAFLHLGDGVDTNLCSDKLKNLLTYSCSVNWRFMVASPMFCPLIVCALVYFSPESPRWYIKKGNYKSAFESLIRLRHSNIQAARDLIYIHVLLEAERRISDRRNRIVEVFTIPRNRHALQASLIVMVLQQLCGVNVLAYYSSDVLVPGGPGRDSKSVTTALLGSMGFGIINFVFALPAVRTIDTFGRRNLLLFTFPLMALCMLLTFLLDRIPNSGGRAPLTLIGMYLFAAVYSPGEGPVPFVYSAECYPLYIRDIGMSIATAVTWFFNALLTITWPPIKDSIGSAAFTVYAALNLVGFVFILLLVPETRNRTLEELNSVFEVPSRDQAMYGMRQLSWFFGKSGEQSGVSRDEGELRCRLWESGPAGGDDRNFPADISPSPVSRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYE2</accession>
    <name>A0A2T6ZYE2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1171382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYE2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYE2"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="270" mass="29269" checksum="397D7467F1B47859" modified="2018-07-18" version="1">MWISMLDCTQPPPPQKPPTLFHPSSRILLLGEGDFSFAASLVRHHCVRHLTATSLDSEAELLEKYPQAAGNVAVVRGMAGGGGKVGRVKAVRKRRGEVVPGPVEEGGKEGEEGEEEGRKELGGRGVVGFDVITFMFPHIGGKSTHLDRQVCGNQQLLQSFFTSVKPLLSPRGVIVVTLFEGKQYDLWDIKGLAKAAGLQTRTSFKFAFEDYPGYAHSRTLGNVSSGGWKGEERNARTFVFEVGDRERNSAGGGGGRQGKRKKQDDSSGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYG7</accession>
    <name>A0A2T6ZYG7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1079138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYG7"/>
    <dbReference type="OrthoDB" id="3783539at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6993" checksum="E3609C91AA4944F2" modified="2018-07-18" version="1">MNNQTQHIERRYIRKNMLMRLLTQLFGENFEIEVIDESYRLNVPRPLTEEEIEQISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZC6</accession>
    <name>A0A2T6ZZC6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1191624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZC6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZC6"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU80795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="273" mass="29982" checksum="1C962C246D4BBC3C" modified="2018-07-18" version="1">MSKFYFDSSPSPTPSPPPSHHHLNNNNNEEDSDDDNNPSTLPFPTPLSRDAFSNLEAPFNPTQFLASLRSRHQTLEDLRAELRARSKELERELVELVNRDYVDFVGLGGSLKGGGGRVVDLRMAKNLLTLSYRLDELSTLLLIHPPSSSSSTTTTTAVVSIPNFDDQEGESSSGGGESSTPSIPRLSRILLGYLFVTRNLLPKLPLQHPFVKMQIPRIEAVRKTLLLDLDSALKEARSSKDSDKVLVLLGFYADLDAEAEGVRALKEGGKVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A042</accession>
    <name>A0A2T7A042_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000051">
        <property type="protein sequence ID" value="PUU81094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A042"/>
    <dbReference type="STRING" id="42251.A0A2T7A042"/>
    <dbReference type="OrthoDB" id="5416307at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="37969" checksum="3A86B1AA00578948" modified="2018-07-18" version="1">MDESYVSSDHSGYVRLPSPVNGGLDPNVLPLRNRGSLGEHQPIPIPSSLLQALEAKVTEKETHIRKLILDKDELSKKINDLEGRVDALEGDKLSLERQVKDTNCVKEIPKTHPLEEEEQTQSIEEEILGFRRQLDEENEHFNGVEMEKLSLQKRIAELEETRADQEKSKEDLESRIKLMQTLEKEICLFESRLADLEAARNEIASKDLQPHLHSRSVEEQLRIVNAQHWASTATMNRIQQTIFNTKLATWKVTNEMKSLKNGLDKATQESKASRIRMAQLSRATAEKIAKWAPLRHADDIKSRRQIAAFDNLLSEIDYTAMIREVHQEIIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A070</accession>
    <name>A0A2T7A070_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1062898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A070"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="136" mass="15467" checksum="2381C3D5AE3D1282" modified="2018-07-18" version="1">MSTTQGFFNWMEWLIPLPIKAPPKLAHETVIDMNDMQPCLLCLPITRKVKIHQAITTSLNLVISTDQILSRVHPTSLKQIRPSLIHLSIKEAKIITDAISAKRQAYSAQPPWKINEVAERASFWPMKNSPTNPTTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0E0</accession>
    <name>A0A2T7A0E0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1062876</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0E0"/>
    <dbReference type="STRING" id="42251.A0A2T7A0E0"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="414" mass="45946" checksum="2E626DE71FE82550" modified="2018-07-18" version="1">MSQKAEKNRLYKVLEIAPDASEAEIKKAYRKLAMKYHPDKNAHNPDASDKFKEIGHAYEILSDPQKRNIYDQYGEEGLSGEGGMGGGMSPEDLFSQFFGGGSMGMGGMFSGGMQQQGPKRSRDIVHVHKVALEDLYKGKVSKLALQKSVLCSKCQGRGGKEGSVKKCTGCDGMGMKTMMRQMGPMIQRFQTVCSDCNGEGEMIKDKDRCKTCHGKKTITERKVLHVHVDKGMQDGQKVTFKGEGDQGPDITPGDVIFVIEQKPHPRFQRKGDDLYYQAEIDLLTALAGGTIAVEHLDERWLTVTINPGEVISPGVIKVVRGQGMPSYRHHDYGNLYIQFDVKFPPDHFNEPEKIAMLETILPPRNIPEIPADAMVDDVLLEEVDQSQQARVNANAMEDDEDPHQGAERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0V1</accession>
    <name>A0A2T7A0V1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">B9Z19DRAFT_615463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0V1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0V1"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000024">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU81358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="129" mass="14004" checksum="93847F9B8F74057D" modified="2018-07-18" version="1">MLPLSLLNTAQGHPMLVELKNGETLNGHLVNCDTWMNLTLKEVVQTSSEGDKFFRLAECYVRGNNIKYLRVPDEIIDLVKETQTQQNRDGHGGRGGNDRGGRGGYRGDHRGGNRGRGRGRGRGGGGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A145</accession>
    <name>A0A2T7A145_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1062595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A145"/>
    <dbReference type="STRING" id="42251.A0A2T7A145"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="439" mass="48127" checksum="48D5832B28C89205" modified="2018-07-18" version="1">MPGIGFFHHHHGTSPSTSVTSILPIDSKHPAPKRRWSSNRSSSEGDRPRPTIRTMTKGSRGALKGFIENPADISMTIESPPLVCYGPPKESTGALLSGILKLEVKEREQTFEAFTMRLLVDVLTRRPVSAHCSDCTTSVSELHRWPLISEPVVLKKGTHTYPFSYLLPGHLPASNNNALSRITYCIYATATTIKGDEIKFEKPITLQRSILPGPDKHSTRVFPPTDLSANVTLPPVVYPGGDFPLHIRLDGVLSKARTNRWRLRKLSWRIDETSRVVSPACKQHNSKLGGDGKGLLHEDVRTVSSGEVKDGWKSDFSADGKIEVEFNAGIPAHVGVACDVDSPCGISVSHNLVVEMIVAEEHCPVPPSRMVHPTGAARVLRMQFHLLVTERSGLGISWDEEIPPVYENIPASPPSYGTVLEVEGEEGVALFCPPVYHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1K5</accession>
    <name>A0A2T7A1K5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1165162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1K5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1K5"/>
    <dbReference type="OrthoDB" id="10525816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="261" mass="29163" checksum="6D787C32F042DF07" modified="2018-07-18" version="1">MTGSPLPPTSPVPETPTLPTAPKIPMTPRPARIMTPHPARILHSPTPQALPRHTFTPIAQTPDRNRTPTRNFRFRRRLRSSIIESSLSRTPTPTPTPTSSPSTTPTTSPTNSPTPPRHCTPSYTKAQKHITNLRSILSRVHALNLNPRRFTPEIRKSLAGIEWGLYVLLEGGDVYQYLFPKKEGRGKGVWMDADIEGLVRRSGFWVRVWREVKGVVGDFEEAEGWGVEVEVEGEVGKKRKRGEEEEEDAEGKVQCAKKGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Q5</accession>
    <name>A0A2T7A1Q5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1099603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Q5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1Q5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="343" mass="38596" checksum="8F6464AB2E9150F4" modified="2018-07-18" version="1">MANTSNNVPARPLEVDPALSSKVALLFFYSYRNILGIDTKMGVDTMLIKTGKEPASRAWYPIELISHRKYVIPNDEAEQERLDIVHHVYLLLLDGKLVRAPVDDNIQRILDVGTGTGIWAIDAAETYPSAQVIGTDLSPIQPSWVPPNVSFQIDDAESEWTFARDSFDLIHIRHLNGGIKDWGRLIKQSFDALKPGGWLDIAEYECELKSDDGTLPAESNLCRYYALVNQAADKLGQEFKIAASLDKFILETGFNKVHHEQMKLSLGTWPADKKQKEMGAFLLLTTDNVFEAFGMALLTRTLGMGIPEVEELITGAKKESRSKKIHSYLLQHLYYAQKPFKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2S5</accession>
    <name>A0A2T7A2S5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonucleases P/MRP protein subunit POP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1105984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2S5"/>
    <dbReference type="STRING" id="42251.A0A2T7A2S5"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="53"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="508"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="816"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="881" mass="98196" checksum="19E0746AA6BF5FC7" modified="2018-07-18" version="1">MPPSTPNPRKRGAATMPISGHERKRAKLHDARTIAVQNTEQALKTGELDVPAFIKSREFEIEALQNAIKASKESSNKRAFQIVPRDMRRRTASHNVKRVPKRLRPRATREMQSDNTPTVSARRRKPSGSLRLRKETARKLQTMAKKKDITAKILAKISGGRRTENVLRQPPRAQTKFRKRQKHKTWLPTHVWHAKRAKMIVRWRFAVAETPTEKSYRVAHRASGMRGCIAWDESYYSTIMLRGKERDVKGVMKALCPKDGNPMSKKVVAGTRASDTFAYRAGRYPLGLIAPIKVIWCAPEDSEAPLEDRIRKLLIRVHPSAFLELWEELLPTAKPLKVTVEDLRFEIGSIEVTGPDATNSLLAVLNPTDATDEDSPSGVWKNLRGLTNPSSLPLGAYLSFDVSDPRLRDPPRLPEDRRRLEEIQETIFKVTSTWSIDRTQPPSSLFSREARVAAVKSQSSQKKINKRRGEAVPGEHPPPLPSDPRIPIVLLATRRSSSEKGVSGAIGSWTILLPWKWVQPVWYGIVHSSSNVKFGGLDELRQINYENSNRHFPDDFPGTKAGIAEELRKGVERKEWWDKRPKGKRVEWGSVKIGNKRGEVGDGFVCDWAYLLKGKEIDITQSDDSMELSTDATESTKSIASTRTAAFMSATESTGDTMSIPAAELDVSIENSTYPESVMFSMDIDKPSPNIPVISSSIPTPTLFKDTPTATTATPSKQSQQPHPWIIPSSMVRYILAAPNSPLPKPLATVHPTILSAGIFSIKLFFPQRSTPTPRARIYSLPTNSPALKAKWRTVMSQKSRGKRPEKAAELLDVPGEEDLIGFVTTGDFNLKEGRGTGVGALSWQKVFGRGKKVGEAVGKACIVRDVGSGIGRLAYWEVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2T6</accession>
    <name>A0A2T7A2T6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bms1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1075721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2T6"/>
    <dbReference type="STRING" id="42251.A0A2T7A2T6"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="61"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="378"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="536"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="617"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="682"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU82052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1139" mass="128719" checksum="5CDEF0EDAEEE9FEC" modified="2018-07-18" version="1">MDQLNKTHRKPKEKKKFTGQNPKAFAFANPGKLQKQATRSHDVKEKRLHVPMVDRLPEEPPPLIVAVVGPPGVGKTTLVKSLVKRYTKHTLSSIQGPITVVTSKKRRLTFLECDNSLTSMIDISKIADIVLLLIDGNFGFEMETMEFLNVIATHGLPSNIFGILTHLDLFKSQSVLRTTKKRLKHRFWSELYQGAKLFYLSGVINGRYPDREIHNLSRFISVMKNPRPLVWRNSHYYMLADRMVDLTDPVAIEEYPKVDRKIALYGYVRGLNFPNEGARVHIPGVGDLSVSSVESLPDPCPTPARTAAEGKGRKRLGEKQKLIYAPMSDVGGVLVDKDAVYIDGVGERLVIGLQRGKRGEADGVRLFTGGEVLKQVRDDEEGGNVGRKYKRSARTLEPSKDSTDMEGYGAESENEEMGFGDFASGDEDEGASDDEDITSESFQLGKALRGDQDEEGAEDDITFAESDSDLGSVSEVSDQEFDEDDLPSDEDEDDEDIPRWKQDLSANAKQLWMRSHRTVNLSKLIYDESLTPTEVIQKWRGEHEPKSQEKSKNTSDGSDSEEDFFKKVEEEDGEDDGKSFKKIADRSLPIYDMEKLESYWSEESALEDLRRRFITANLLEEKEKGEREDGESADIGDSDDEGDGAFEDLETGEVHSGSGGEKGGGGGGRNESKGDDEETSLEEERAKNARKKEELRLRFEEEDREGINNDKTGDGKDAEFGEDDWYDAQKAKFAKQLAVNKAEFEQLDDAIRAKVEGHRAGTYARVVLPNVPYEFVAHFDPKYPVLVGGLTATEDRFGFLQVRIKRHRWHKKILKTNDPLIFSLGWRRFQSIPIYSTSDSRTRNRMLKYTPEHMHCFGTFYGPLIAPNTGFCAVQSLSSKNPGFRVSATGVVLSVDQSTEIVKKLRLTGTPYKIFKNTAFIKDMFNSSLEVAKFEGASIRTIKRALANAKQEGHFRATFEDKVLMTWYPIKPRKFYNPVTNLLKDTALPDAPAWNGMRTTGEVRHELNIKTPTIADSTYKPVQRSTRRFNPLRVPKAIQKDLPFASQIHQMKPRKKTTYLASRARKARDLMHKIATLKKEKEAKRREAKEKKREVYRKKVAENMEMKTAREKKERDEKRRNSEGAGGGGKGKRRRGGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3L0</accession>
    <name>A0A2T7A3L0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3L0"/>
    <dbReference type="OrthoDB" id="5467127at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="242" mass="26663" checksum="6C170230C7331E93" modified="2018-07-18" version="1">MPNKSWLAVLRHYTLQELGEAACRYVEDGEHPRQFIGILRDIQGLNVTPDGADQIELIDDDQVNAWLRLSQCSTLTVACFLHRAAVAPPDGGDPVRPNTPLVGHSRNYLFPGQFDVAEFYTEPESDSDEEDDVERHARRRRAFPRSHNGWQRRILSNDRRVVRFQTHSRELISRARVRQGPAYMSRYAGQDVPMVALPPGIPPPGCEVSVHDAIEEGADDNGGGNGGMGWGDGGNGGNGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4I6</accession>
    <name>A0A2T7A4I6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_966898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4I6"/>
    <dbReference type="STRING" id="42251.A0A2T7A4I6"/>
    <dbReference type="OrthoDB" id="5337208at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="557" mass="62076" checksum="BD93D0DAD786E393" modified="2018-07-18" version="1">MEVFTDVAVDSFRTGFPSFQRPTGTKTGSEPCIAVTSRQGQLLTALYSIIVTLLFIVCWKIVSLAVMLLWSVSRGIALVGFWNAREPLEATCFTLGYLKRACAGYHIPSPTIRLLLLAVVWLVGTYAAGIFVAAELISGKVAPANPNKVYVPRPPGMSSADIMRQQALVAPATLRSLGSAEAAGNQHTIRKYISFDRFPRDKESLQNFTYKYTVTAHDMGLQKWHDLKQEVSGQCKVDSSWFSKNVPEEDLDVYRPWGLANKTVDVVYDGERKTAPSATAIPFPYAEPNFLINNKAEHRYGIIVHSSHRASYRLGTDPWYQTETFTTRDNETDARINTPPGNRVMGGRPALSCTQNDVWSYNGTQFKNIYELTDEANIKFPEGWVTQLQMDFSGPRIIEVINSAGSSSLASATTFVGGVFDAETSKIEVDMKRLLTATWISSAYTFRNMLMVDAEQNIDNVALKGTGQPQDGVDLFVVSTPQVATLRLSVLFAIPGLLAFFTFVLGILTIWGRRDKERYKNIHFAEGAYLYARTQDPVKFRDIERLGKVIRKCKQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4T6</accession>
    <name>A0A2T7A4T6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1074305</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4T6"/>
    <dbReference type="STRING" id="42251.A0A2T7A4T6"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="99"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="279" mass="31513" checksum="10D78FE07F04F282" modified="2018-07-18" version="1">MPPPTNTDQLTNQIDHRALRIRENGGPANDIVPTESTTNQRRRTSVALALGDAHPRAELEASRRQFVDYDGLSWPSSGTRERLEATPDEAEARLEKLSGAIRTILECIGEDPDREGLLETPSRYAKAMLYFTKGYEENLKLIVNNAVFQEDHDEMVIVKDIEIYSMCEHHLVPFTGKMHIGYIPRGKVLGLSKFARIAEMFARRLQLQERLTKQVAVAIEEILEPLGVAVVMESAHLCMVMRGVEKTTATTTTSSMLGCFRKRTRTREEFLRLALNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A532</accession>
    <name>A0A2T7A532_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_302368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A532"/>
    <dbReference type="STRING" id="42251.A0A2T7A532"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="971" mass="108598" checksum="6C57C6EFD61E58F1" modified="2018-07-18" version="1">MPRAGIKEAHPAGIWSDLSVDGPVIGTLIVVLDKAKNLPNRKKIGKQDPYVVARLGKEAKRTDADVRGGQTPRWDKELRFPVRNSPDYKSLKITVFNDDKKTDLIGETTLKLDKILVKGGGTDDGWRGLKCKEKYAGEILVELTFWDMRPKDPPPAGGKRLEQDLGGREKEREREKEAPRKVGGAREMVSSKDRTVKRRPLPSDPTRSSREDVSQPVPVPEKRTRRSRHSYHPGYENNPHSQHPFPEPQHPQHRIPRGSSRTMAMAPDPLPVATGIYDPYGDSHIPGGEVFGRFEEDGDPHGQPPPPPPPTHRRHYDASPGHHSPNPPHLPQQAIHKRHKSQHQLKHYQSVPDWQYHQQQQQQQQQQQQSHSPDPREREMHRSNSYDPRFPAQDQYGGSYPGPQTRYHGQDDYNEYAYSPNAVASTAHLRQERPLTYQDENPGLSYGPTPVSSFEDFRDEDDAPPPPPPPHGHSPAPMRFDEPNWGNHKPKTKEEEDLGLPSYELSTQLAHRRSYSNMNARAPEARGPSVGIEPSPTRNGMPIPPSLVPGIDPFVAEQMSGRIEAERGLGFADMSSGPLQIEGPQSHSQVIQHRSSQNYHRPQVEEVQDVQLYQPQLLPEDQVVGRPVTVKKSREQRSAPMVKPMPIHGERDDVVPVVGATANAVRRNSTLVMVAPERKPVPPAEPVFEGLPFSPDSFDLINPGPSASLEAAINGPGPTYNTPQEAEATARRWNAESKRGKLPSKMIVPGTNRVLDGTDVLPPESFAPEPERRGGRSPRPPPPVPAEYRRHSIGRQRTPSPQPPRRGERLALTGPVPPPLPKKVSIRGPSAQPDRGEKERERAKLQKRLRNSQSMAILPSNSRNHGSSRDRYSIGPGAMVMYNPESERERQMERDRDSRALVPAKGHDRYGYNSDQPRGGRSQQRQSAPPLPAKIPIDTTGMSREDYLLSQEMSLISIGPTSGGRTRRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A584</accession>
    <name>A0A2T7A584_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A584"/>
    <dbReference type="STRING" id="42251.A0A2T7A584"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="478" mass="53263" checksum="170FCDC25BBB4D1A" modified="2018-07-18" version="1">MSAEIFKEIKDAILTRNHDFLLYHDVAQEDFEISWFSRDKLLKVVMPSKLHECPGAWLYEMVTAAAIDGILPRIWTKTMQISPSPVYDNFKGDYKQSVKEADLTFVPLVGPEWKNTAEYPSVVLESGWSESEAALKRDVRLWQLGSEKAVRVILLVKFFAENPMRVQLSITRSSPFAISIPEIFPAPKCAQEDPCISLGEFYAGMCPSGVDPTSRVRLNLERLLGKAEVCVEKIENCELGSRRDCSGKVPPRGSRQIEWEERRSNSISPKKSFFTYATPPEVSPTEPDATGDAGKQVGGSLPENFAASDMWRLDGQDGSRGLSCDRRSIPFLARGNASSGAGYAEQSHGPMYLQYILSSMKSGAKRIVKSMESSRVRTFLCAMPNNVYTVNSSESVARQQLPEDIMSLPLLQAIPSDPTRYSRADRSVHLFLLISRADDGATDLPPEVFMKKMQIHIAGIGPVFRLGTRWGLRCGVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A585</accession>
    <name>A0A2T7A585_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A585"/>
    <dbReference type="STRING" id="42251.A0A2T7A585"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="56" mass="6187" checksum="B365080C5535D736" modified="2018-07-18" version="1" fragment="single">MTQAPGIGIGIVGKEGHRTSLTRDLSIEKFCHLTMLMRHGRNSYKAHAIEYAKASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5V9</accession>
    <name>A0A2T7A5V9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5V9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015551583" description="Secreted protein" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9460" checksum="47F0404E3D71F596" modified="2018-07-18" version="1">MLPLMLLVPVLMLTQEPHMLLLALLVVLLEPGLPVSPPNSLSTSLITTKLVCIPCARRSSSKGSDKYLSSWYVGRVFFAGGSDSLSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A627</accession>
    <name>A0A2T7A627_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ORMDL family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1098749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A627"/>
    <dbReference type="STRING" id="42251.A0A2T7A627"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="20465" checksum="BED30E3F1B59BDFB" modified="2018-07-18" version="1">MSDAAHGRRRRSSSLLYTEPPETIEQQSDQAALPNLNASWVNSKGAWTIHVVLIIALKIFYDTMPGVSQETSWTLTNISYMAGSYLMFHWVQGIPFEFNAGAYDNLNMWEQIDNGDQYTPTKKFLLTVPIVLFLMSTHYTHYDLTYFIINCLAVLAVVIPKLPSSHRMRVNLFTVPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6L1</accession>
    <name>A0A2T7A6L1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myotubularin phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000014">
        <property type="protein sequence ID" value="PUU83376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6L1"/>
    <dbReference type="STRING" id="42251.A0A2T7A6L1"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="1">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="20580" checksum="C137BC08D7DF8585" modified="2018-07-18" version="1">MEHIRDFKVENVIILHYGQPTPVKQPREIWIIYFIVSTRFRHPFKTERDCRLGDVFESINCLSIVKGVDNLYAFSYAPGSIEKQFNGWKIYDPRKEYERMDIGTKRSTISDTTLSKAKNYLSRAGNIYPLNNCSITRCSQLLTDVCGNRSIQDEKLVAAIFASVVWSKSSQVWLQISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Z8</accession>
    <name>A0A2T7A6Z8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_49121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Z8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="18999" checksum="A9D67E6A9F182CF9" modified="2018-07-18" version="1">MMRCLLVTNSLTFQVELWYLKGLWDPLGRQAASAANRLLSFSLFCCSFLIIVEIVLSRNLYRQPHPLRHPSIPLLHTGTCGALAHGLWRGCCAAGLLKNRALSGSSDKVAVLCLQAVIPVAPSVQGRVRTTKDETVSSLDGRTSLAPSWTGWTDGPSAADTQNWSMRQILPTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A772</accession>
    <name>A0A2T7A772_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1072054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A772"/>
    <dbReference type="STRING" id="42251.A0A2T7A772"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015761207" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="186" mass="19817" checksum="C7832865E53EE60A" modified="2018-07-18" version="1">MKSAIFSSAIAIFTTLATAVPTAAPADIVARDQVKQVILSSAVVNIQEDAANTPLGVTYKAIVSRVNGKHNSQALVKFDFPDGLTGYKCKLDFAYPAQFSGTGEIQVFSIGDTNIENATFNKRPFRDQFKGTFRVAGWGEAVVLDASGLTFDCPAKGAKAYEVVSQGDSNDVEWYAPGGGLRIDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7A4</accession>
    <name>A0A2T7A7A4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7A4"/>
    <dbReference type="STRING" id="42251.A0A2T7A7A4"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="21"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="418" mass="47610" checksum="1890473169AD5E12" modified="2018-07-18" version="1">MADKKIKVLPLEPSRRGAAFSSAVFQINAEKGTRTFYVHGDILSQDSQPFKSIVDGNWAESVKREINLEEWDADTVSRMIDYLYTKDYTWQKNENFKLAPAAVLEKSPSAEHSPDAVRPLTPISELMIYPQRGRVWGCQCNKQSLGHIDKEEAFGELFLVHAKVYALANYRAIEKLSELALDRLLHSLSLFQATEYNPQQIGYIVQLVSYVYENTCSRFGKPEPIRRAVTRFIAIELTKLDSTGGISELLNTYGDFACDLFSDLTKRIRLAEVQSEIRHKYLAGVKAYTGALQPFNCIKESLWRSSNINFGTGAEPVWLVPYYTEDVDKACTSFQVIMYGQEGYDHRFKIPTNLEDRRYPCLISICDRNIQSKVSHVQLVRVTRPGQVDDIQRRCKATGVTTDILGTAHSDILHLMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8A6</accession>
    <name>A0A2T7A8A6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8A6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="130" mass="15267" checksum="2CCA0E3B60B40679" modified="2018-07-18" version="1">MSLCNRRERDAERDLGPGLQEKVDALKIRVTSWEQLDSKCFSKGVKRAERGEGKCGGGLISWPLEEDKENKEEDKEEDKEENKEEDKEEDKEEDKEEDKKEDKEEDKEEDKEEDKEEDKEDNEGKDKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Q3</accession>
    <name>A0A2T7A8Q3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1071046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Q3"/>
    <dbReference type="STRING" id="42251.A0A2T7A8Q3"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="352"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU84109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="404" mass="43124" checksum="34A9CC53AC42AFBC" modified="2018-07-18" version="1" fragment="single">MPLAASSPLTIPLQITLSQFRLTGFIILVFSKAKGITLVFQNDPLESLKVSSTFDTIPFIKDYLQKEIERQVRGLFQEELPVAVHRLSLRLWNPEYAASLGLDAHDPDPSSLVDGSEDGAGDDATAAFTNPLLSPSDSDNSDTPSIVFSQKNLAALKGLSEAQKTLSMRTPDISDAVFRAWASGGGSSSVGWEKNVDAPSTPIGPQTYTFSDTGEAISSTTSISSSRASLTTSSSSLSVGGGASTPSTRARGKKKKHRIVNLRPAKESAHSDSAPNTPAALPQTATSSSADRKEEDLPTPRTPTFPTPLQPQLIPSTPTTTATSPFSQGEKIVFESPISPTSSIATENITYPQTSPSEHRRPQLRAGSAGSSGILEQAFMKKLTHEMQKRIEEERRKRGIMGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Y9</accession>
    <name>A0A2T7A8Y9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1070419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Y9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="7777" checksum="88F926F5290EEF25" modified="2018-07-18" version="1">MVYIYPQPLCYVASFDINVTASTSALTSERVSTGPVTIWSELSLIPIPLYDDDMIPARTQTGVVMVASYCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA64</accession>
    <name>A0A2T6ZA64_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1010436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000554">
        <property type="protein sequence ID" value="PUU72375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA64"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA64"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU72375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="24358" checksum="D9A713EE34087BEB" modified="2018-07-18" version="1">MSSLPANVAVSSHPCFISKLSLLRSASTPPKETKALVHELSLILATEALGRALTVEKTGEKGITPLGVSFDVEKVTKSIALVPILRSGLGMLEAFQTILPQPTPVHHLGLFREKVTLQPVEYYNNLPTRVDLSKDDKNPPCDIAIVLDPVIATGGTAEAAIQTLREWGVPKILVVSILGSVEGVARAASDSNGEGLDVVVGAIDRELGGDNGGMIVPGVGDIGDRLFLTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAF9</accession>
    <name>A0A2T6ZAF9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1137551</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000531">
        <property type="protein sequence ID" value="PUU72465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAF9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAF9"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000159">
        <property type="entry name" value="Casein kinase I hhp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="12"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU72465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="423" mass="47585" checksum="FCA4D7152480FE67" modified="2018-07-18" version="1">MTTMDLRVGNKYRIGRKIGSGSFGDIYLGTNIISGEEIAIKLESVKAKHPQLEYEARVYKSLAGGVGIPFVRWFGTECDYNAMVLDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEYIHAKSFIHRDIKPDNFLMGIGKRGNQVNVIDFGLAKKYRDPKTHFHIPYRENKNLTGTARYASINTHLGVEQSRRDDMESLGYVMLYFCRGSLPWQGLKAATKKQKYDRIMEKKMTTPTEVLCRGFPNEFAIYLNYTRSLRFDDKPDYSYLRKIFRDLFVREGFQYDYVFDWTVYKYQKNAQAIAQAAGGQQGPGEDDEGKDLNKRGTLRTNAATAGHPTPQTSSKPGAVGGSRRKVVERGVDTPGTMDTTRGLSGSDRMLRSASKGAQATNPGFAPQAGGYRVNKREDQPSGSGGAQQQWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAS9</accession>
    <name>A0A2T6ZAS9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1096972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000502">
        <property type="protein sequence ID" value="PUU72579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAS9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAS9"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8278" checksum="CE591BDB0D576140" modified="2018-07-18" version="1" fragment="single">MGAVKLMDDERVAVEPACGISAAVIYDSVLRKVCPELGPESNVVLVVCGGNSISAEMLVEYRNTYGRLDTPAAVQAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAW5</accession>
    <name>A0A2T6ZAW5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000495">
        <property type="protein sequence ID" value="PUU72625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAW5"/>
    <dbReference type="OrthoDB" id="4157208at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="8747" checksum="A67639F129F2C062" modified="2018-07-18" version="1">MSSSSSNTNNESTLLVPNPTPTSTSRRGSIPRNTPAWAGVGDASGSGNPEDPASSLRKEMNLVAEAAKRASVAIVVRDMQEFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB15</accession>
    <name>A0A2T6ZB15_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_914383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000483">
        <property type="protein sequence ID" value="PUU72681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB15"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="90" mass="9937" checksum="C0223459667F4913" modified="2018-07-18" version="1" fragment="single">LFQHLLERLALDPKDNLTTLPCACFRGHLTLAKLLINYVFDLNEKCQTLGRTPPHFAVAADSEEIVEILLTAGADPNIKNNAGSTPLHWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBN1</accession>
    <name>A0A2T6ZBN1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1166185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000446">
        <property type="protein sequence ID" value="PUU72900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBN1"/>
    <dbReference type="OrthoDB" id="5412732at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="20612" checksum="6031A3C51532DAAF" modified="2018-07-18" version="1">MVDVTITAGRKAKTAKQNVSTNPTNHYPHHYYPIPTSPIPNPNSTPRPSSHQSGPITHHWNDLPPSLLPKPYSASASRSTSPHPQQPQPLPQPSPPDLETLLEPLIEKLFSAQSTIPDAQRRQLKEKVLRAAPGMSDGQRGEVVEILLRWDGGGGKKEGREAVVGFMVRERGVAGWAMCLRRGFEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCD5</accession>
    <name>A0A2T6ZCD5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B9Z19DRAFT_1006013</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="NESQ01000412">
        <property type="protein sequence ID" value="PUU73106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCD5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCD5"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12303">
        <property type="entry name" value="RRM_spSet1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="1063"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="21">
        <location>
            <begin position="1189"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="12"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="336"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="620"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="770"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="775"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PUU73106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134011" checksum="349722F5A361EB90" modified="2018-07-18" version="1">MSRAGYADFFPAAPSVLAEKEKKKAQAEKQDRRARNVPDDYDRESNAISVPNLGRIHSSSCAPISVGVSLPSEHLVTTSTLTPTTTSSSPPPPLLSPSAEAATKGDHPPPKLVAQSSSAREPYPLPPPPIPPPSAPLTPKSTPPAIKSDSSRRNWKVKYDPFLEKKGVPKKSKEPILRWDGEGITTPVTDPRLEVERYTDGPKTGKKRLRSQGLYRTRWKWDENYIGPGPPSQILITGLSPLTTETEISMHFRPHGDIQTLEIRIDPATGGSLGICSIIYRDSPRSRSPAHEAAKKAAQAVNGSRVGIQQVRVELDRDGLKCKKLTGKILEEKRRKEAEAEKKNRLKQPLNISYGEPSSRPRSPSARGNSPSRRDPRTESKSDDRGSDRSRDQRPTPALRPDNYKALDHVGRLPYIFITSRCIPGDERYVRHLNGRLKNFGLKDILWDRTGFYVVFWERRDMERCFKVCDGDRLFSYTMIMEKHPGSHRSPSPPPAVRPEPRKMGPNELVAEATNALMKDMKLVLMKDLRKRLAAPTIYDCLEVGRVNKRLKVEEEELQGITAGSRQVLAVSLEASVRSPTALLPTLALKSTEKLTSVVAKSALQKPTALPRFKKRILTKADDSSTPEASPLLHGSRTKLSKADARPLAHRLNQYNSDAGSDDESTITENRPVSRGSRALSLDTGDDDSVSVAPSANEGYRKRKRSVGPTSKLRDTAVSTDDEDQGLEKDDGSQGLHDLKKPRIDHPEPYEDGEVYMGDEVDEEPVVTTPHRALTATTQLKSTSKNKSRSIESDSEDYEDEMVFKTDPKTESELINTPDDEDDSPSPDIEVPSRTTHSRESRKKIKTAESRANRDLLAVPSVDADGEEHDSEMAGMDIEVSWGVSTTEGPMVTVQDDPDAILDIDGLQNLVKDAEDFKFLTQALAAVEPADLDNVQAWAYKEKQLKVAQTQSIVRSQEKIDGFYRPNPTGCTRTEGYRRVPETEKSMYLPHRLQLAAKVKSAANNIQEATAATATSAAKNPSSTSRMNRVNNRRLVVGLNNQKQMLSSDTDVMRFNQLKKRKKPVKFARSAIHNWGLYAMENISAGDMIIEYVGEIIRQQVADMREKKYLKSGIGSSYLFRIDDTTVIDATKAGGIARFINHSCTPNCTAKIIKVEGSKRIVIYALRDIRENEELTYDYKFERELESEERIPCLCGSSGCKGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCL5</accession>
    <name>A0A2T6ZCL5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1069175</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000401">
        <property type="protein sequence ID" value="PUU73209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCL5"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU73209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="18684" checksum="1F8969D3A58092E4" modified="2018-07-18" version="1">MSFAAANKRLLKEYKALLKESPDGIAAGPIDESNLFEWECLIQGPEETPFEGGVFPATLSFPKDYPLNPPKMKFTCEMFHPNIYKDGTVCISILHSPGDDPNQYEDASERWSPIQSVEKILISVMSMLAEPNDESGANIDASKIWRDDRKEYEKRVRACARRALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCW9</accession>
    <name>A0A2T6ZCW9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B9Z19DRAFT_1095310</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="NESQ01000388">
        <property type="protein sequence ID" value="PUU73319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCW9"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1110"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1159"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1189"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1240"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="1047"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="802"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="912"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="913"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="914"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="994"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1000"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1020"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1023"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1024"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1024"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PUU73319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1284" mass="139986" checksum="19C52E238804C770" modified="2018-07-18" version="1">MSSYIRVSSPSPSGESSDLDLDLEELDPTSGGGGVGSGGGAGYSVGYRSVLGENHRSSFSPTRRGRTSVDGAGGPGRIALRRMKGREGPEDEEALLGRRSREEDIHDEEETSNLRDGGVAGGGEMRLLRRLGSRISLRSTTGEDAVVDFTPSKETRVVGLRPGGAGGKYPPNIISNHKFTAFTFLPLTLWHEFSFFFNLYFLLVALSQCIPVLRIGFLSSYIVPLVFVLSITLGKEAHDDIARRRRDTEANSEPYEVLSFTDGGVLKRKKGARLGKKKSATGAEGQELREGGDDSDDIRIVSKKSKDLKVGDILVLKKDDRVPADVVILKTISNEVNQAEEGGGNDTSGEAFIRTDQLDGETDWKLRLAPALTQALHCSSLAYLTITASAPSKEVNNFIGSISFNPSAPSSTAPSAMGSSMPLGPGASSSSLSALPATASSSMGLSVDNTAWANTVLASNSTTLAAIVYTGPETRAALSTSRSRSKTGLLEKEINNLTKILCVLTFSLSIALVALQGFESGQNEPGVKDSPNPGEVVSGSWYIKILRFLVLFSSIIPISLRVNLDMGKSAYAWFIEHDKGIEGTVVRTSTIPEELGRVEYLLSDKTGTLTQNDMELKKIHVGTVSYAGEAMDEVADYIRLGFSTGGGKDASGGVQAPPAIQLNAATTRTRREIGSRVRDVVLALALCHNVTPTTTTDEGASEATITYQASSPDEIAIVRWTESVGLRLSHRDRKGMKLQSVDTGEVVVRVKILEVFPFTSEGKRMGIVVQFMAGEKSKEPDLLGSGAEEENSSTGDIWFYQKGADTVMSSIVQANDWLDEECSNMAREGLRTLVVGRKKLSIQRYQEFSAKHKAASLLLANRDKEMGKVVEEYLEHDLELLGVTGVEDKLQKDVKPSLELLRNAGIKIWMLTGDKVETARCVAVSAKLVSRGQYVHTIAKLKRKDHAYDALEFLRNKTDSCLLIDGESLALFLDTYKSEFISLAVQLPAVIACRCTPTQKADVARLIRVFTKKRICCIGDGGNDVSMIQAADVGVGIVGKEGRQASLAADFSIEQFCHLTKLLVWHGRNSYKRSAKLAQFVMHRGLVISVCQTMFSIASRGEPIALYQGWLLVGYASLYTMAPVFSLVLDRDVDERLANLYPELYKELTEGRSLSYRTFFVWVLVSIYQGGIIQGLSQILVGLDHFERMVSVSFTVLVLNELIMVALEITTWHMWMIFAELGTALFFFASIPLLGEYFDLQYVISWAFVWRVAAISAISLVPPWVVKTVRRRLKPPSYAKIQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCX3</accession>
    <name>A0A2T6ZCX3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1004954</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000385">
        <property type="protein sequence ID" value="PUU73345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCX3"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="117"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="765"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1387"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1432"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1396"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1454"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1514"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1552"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1576"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1622"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1645"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1666"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1734"/>
            <end position="1757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1812"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1837"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1858"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1896"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1954"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2044"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2090"/>
            <end position="2108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2116"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2225"/>
            <end position="2263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2278" mass="255123" checksum="3225722BE2F9491B" modified="2018-07-18" version="1">MPENRLIGRDRKRKHPSSPNNTIPRTSPYTPNRPADNYSPRNSGGGAGGNRSGRRGRQSSTSQQQPQQQQLTLQQPPPHNRRRPEDTATATDESAMTSTPTDPGTPGDFYYWEFLSDVNLRAWQSEGAARVQEALGRSIVSEDVDEVCIILQELVKATLEGRISVQDSSKFVTDIINVFPKDTDSGIDLQDLFLSTVANFEDLNAQIPENLPKLLEALSPSPIPTELFALHLEPSTLSALGLVTSQFPKKAIKVTTSLIYKQRKYNLLREESEGYSKLITEFFTASYSQFPLEVVGRTGERVKGLVGAFELDPARVLDVLLDTAASTVVSNARFFVRLLRESAWWPKNLSSSSEDEFSNTGKGREELRAEKERKKLIMDAGGNKVAAQLLGFKFRYYQSDDALDNLPENLVVLSALLIKIGFVDLAHLYPHLSPRGDGEMMELRTAWLKKMTDELKAVKPNALAMAGSLHDDTLPNPPRTKLSAPAPAEEKKPEEPKPKEPEKRENWNQKVALLKHLLALGALPEAMFILGKYPFLTGLEKDIADALSRVLIRSIEAVYAPLRPRHADMYADMGIAKVATPLPGGVEMKTPLKRKQMVTFTVSNLNLRGIDIDYRFFWEDWKDGVPTCRDATDVAILIEHLGKLFGLRIGRDPMLMSMVCRIGRSVLENPNCTQEDRDRWINLSRSIIVPAVSFTEGNQGIVNEVWGMISHFPTETRYSIYGEWISREKMRIPDLKLKTSKTEKETKDLLKRLSLITIKPISLGLAKVAVSSPVTVMQVLLSQVETYDNLIECVVGGAKYFTPLAFDAIGFCVLFSMSTAGKQSVQADGMLTSRWLKSLGQFCGQIYTRYYRQMDPAPVLEYIARQLKQNTWSGLGVLQEIIQSMTGIDPDINLTDSQHRGLAGGPYIRSLILGQFRNSKAEDSPRTMKALTDTLMRSGLAIQLLILIAQARQNCLYQSPETTPLKVLGNLFDQIHVVFGQYSELLQIALPAEKYEEMVPSMGRLCRDFGLKPDIAWWIARSAINTKIQRIQSPDGREDVDMGGTQDESAAITLEKTPWNPVLKNIMDELRPVLPVSEWPGSLAFYVTFWHLSLYDVYVPMATYKNAIASLQDEIAALPDKRSPRSYELLGSTTKLSEEVKTHICHNGLVKKRLQLEKDHWFNEFPDPREVTNAIVQYCLMPRIVLSPNDAIFCSKLIKELHKLVPPKFHTVGIFDAIFGKHMGKTIFTCTQQEAENLGKFLKEVLSDLHAWHADKAHYEREAHNNGKNLNGFAFRGAPMDWEDFRKLLYKWHKTIHSAIKNCLCSKEYMHIRNTVTVLKHIYNFFPSVDWIGRTVLEKVEELGKHEKREDLKIASATLLGLLKHREKDWVLVAAFQKGSLTEALTPVVSGSKQPSPAPTSTPTPTQQPPMDANNASAQLNAASSAVITNGPALATNNTLPSKPDAEKEDGEIDDSKGSKEIKRLPNLPQRPAVPPPPLRRQPSRDPPRLQQSQQSNEPSRAGTPRRDEPLNPRPNQDMSRNLSQVNRGPPPQPNRPLPQHQLPDRPPVQQPHDRARDMRDPPRSIEVRGTAGRPITERLPDRPSDRRPLSPRRESRDQHRRDNDRGRAREDNFQRPALPLRNDDRVPRAGERKDTDIRMEPLPNRSTQQPQPNPVRTDSRSQPPDVDRRRPDRADDRSRRHDRSDLQAHQMEIDRPDPDRRALDRRASDQNLPRQQAPQEDVHSQRPPAAPRADVERERERRNRQEGPSTPKERDLLTGAPPRGPSGPSLSDFRETRHAPPVTHQDPNHGRLNPPDIIPKGPRSAPMGPRSNLNRVASSPALTTPTGTQRILNNPPGVPTPLPSPGLESKPPPATASVDNVETQKPTDNTGASTNGSDTAGIHPDRLRNVVQNPQPLPPLPPSQPQPQSPVTQPQPPPQSSSVHPSRRQAIQGASTAPTSVAAPGPPSGPRTNPISSVVSPAAPSPTTSNPPPPVKQGSPPTGPSRGDRGDEAHHQRRRMMTMQNIIGQASGGADATQGSSTKGRVSRRVGGTSGTPGRDNGRNSLPITTSDTTRRGGNGNGSQNDPTRRGSLAGPEPGRPTSVSGGSAEDRDRERDRDRPASDHGSRSGRHARERGDRERERDRGDRDRDRERERDRVPRDGDRERERERERQVERDRGRERAGMDRDRGLDRDRGQQERDRDREARDPRERDRHLAERDRDRDRDREPRRGSGVIPAIGGSGRDRDRDRDRDKERERRDGRDRERKHGRENDNGRKDESKRRRRGDQGGGGSGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDA6</accession>
    <name>A0A2T6ZDA6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000373">
        <property type="protein sequence ID" value="PUU73481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDA6"/>
    <dbReference type="OrthoDB" id="5479211at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="26010" checksum="1591F6B1BF9D1383" modified="2018-07-18" version="1">MGRKSAETVHTVKTPKHILEIGMTADKYFDLKVDIKSLIARPGMPGFEGKRFNSKENEKVYRQWLHNALLELGPKFFPGGGKGLVWPDDYDKIYKAVNQVIRTLSYKTRKEHGRKMEGVRAVEQTVNDKMEVEMAGDDEHYGDGPAGSTGFGEDAAMAAKEVLQRQKQEKEMTVVEQHDQEEMAEEMRTATELEELLDLMKPEAFDQLPDLTDEDFNWEEAPDLSSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDC1</accession>
    <name>A0A2T6ZDC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000372">
        <property type="protein sequence ID" value="PUU73490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDC1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="20271" checksum="961B08A22FF97035" modified="2018-07-18" version="1">MPRKLALGIQTGGGVLLLPRETSLESILAIEAPHIASCEIVLETPADLLPAPLLTSGSVWQTSGGVAWSAWPPPSGDFVGGRLIENTIQSSQFSLVEPPPRRLVIFRTNACYSQECILLMPTPRRLVVRVRQWTGILPGLTRGIERLVPFKVIELHWNRIFAKMVVGFVAVVGATRRLPCSVPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDK7</accession>
    <name>A0A2T6ZDK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1004097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000366">
        <property type="protein sequence ID" value="PUU73581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDK7"/>
    <dbReference type="OrthoDB" id="88410at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724:SF2">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="49" mass="5283" checksum="71C9EE95B255F482" modified="2018-07-18" version="1">MCMQATCATCGGKSWRGCGQHIPRVLDSVPAEEWCSCPKPEGSQYPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDR0</accession>
    <name>A0A2T6ZDR0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cora-like Mg2+ transporter protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1094722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000361">
        <property type="protein sequence ID" value="PUU73623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDR0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDR0"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55642" checksum="2CC9E896A9FE19A0" modified="2018-07-18" version="1">MARPNGRRNDDDVENNASPPLRIIIPKSPESTHRPSTSRFRLRRAGTVLASANYQDAAPGLEPGLGPDEELDARVNIHTVCGITVVDFSEDEILQTELGNAELIEFLKKPREDWVSVRWINCNGLSWDVIQALAKYRNLHRLAIEDLMNTKTRTKCDWYSDQAFLVLPLLKLIHSEDAENCGSPPTTHPDGSTMGKIRTLQEYYGGPNQERIQYMEKYSSLSSKGLRVSVEQVSMFLTEDGTIISFFENSADDIEPPILQRLESRNTILRSACDGSMILQAIVDAIIDLAFPVIQAYQDTIAELELNVLTDPSVEQSRELYILTSELSLLKSTIAPIVGLVSSLKDHRKGYSDVKGLKGVEVSQLTKTYLGDVDDHLLLLIDSLETMKRAADNMIDLIFNTIGMTQNESMKTLTLVTILFLPMSFLTGYFGMNFEDFPGIKNSDSFFWKIAGPILGITILFLLNGVVGKSARQKWRKRGIRVARERRVKHMKGGGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZES7</accession>
    <name>A0A2T6ZES7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000331">
        <property type="protein sequence ID" value="PUU73966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZES7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZES7"/>
    <dbReference type="OrthoDB" id="5414761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20396" checksum="480D5D85726A43AD" modified="2018-07-18" version="1">MEPNTARKCSPGSLGNESAEESDVLLLDVTEDIYAGDISRLMGVSYLSQAPDLLARDLPVEVGAIIYGPNGRTITSLIVTYKGNSRWVFFLIDTGAPKTFLSLEAYSALGIPWTQELGAWVTIAGRATIVCQSPVKSHFAHVNILGTDFVEKVGLVKLEDYSRKPTAIYFTDDARGTANLWRRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFF9</accession>
    <name>A0A2T6ZFF9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1103576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFF9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFF9"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007858">
        <property type="entry name" value="ORC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="9">
        <location>
            <begin position="186"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="413" mass="45890" checksum="7BD31C5A10234069" modified="2018-07-18" version="1">MLIIGARGTGKTTLLESAISDLTEEHKGEFLTVRLNGFFQMDDKIALREIWRQLGVEMELDERDQPKTTNFADTLSSILAILSHPDELREPDEEGEEPAEQDPSSTTTTLSVIFVLEEFDLFATHPRQTLLYNLFDIAQSRKAPIAVIGTTTRIDVVESLEKRVKSRFSHRTVHLKNPPTLKGFWEICKEGLGVDMDEVDSEINGSSDEDRRCFEAWNSHIEDLYKNDKQFQRHLRRIYAQNKDPKSFFNSCILPLSSLTTSFPTGPSFSLPTNQLGEPDSILSTLDGLTDLELTLLIAAARLDIISDTDTCNFQMAYSEYTALTSTLKVASSTTGVTAGRLWSKEVALGAWERLAEYELLVPAVIGGGSGGGVSREGRMWRVEVGLAEIGKCLEMGRAGVGRAGLGKWCKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGF5</accession>
    <name>A0A2T6ZGF5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000290">
        <property type="protein sequence ID" value="PUU74580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGF5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="307" mass="33470" checksum="78F9F9521876B8F4" modified="2018-07-18" version="1">MATREEIGLEEAAGGRYDEDLDGFDFAQTAIPNPQASSDSARRMTEPHAGEIPGVIWEEERQDDPELVHQQKYTMHQGVWKALSLNPDSGGVRYASAKPFDDVVLQHPICPPPKGRHHTSIFHGATESSEGGVHFGSVSYAIMEPFNDGVVRHPIYPPPKGRPHTSIFHGATESSEGGIPGALGMRSRSPLTTAFYAIPSIQHQKDVPIQILGAIGMQSRNPLTTAFYTIPSVHRQKGVPIRAFSMALHSLLKGGLLYQIPGALGMRSRSPLTMAFYAIPSVHHQKDVPIHIFSMALQSLLKGGSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGH8</accession>
    <name>A0A2T6ZGH8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1133053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000290">
        <property type="protein sequence ID" value="PUU74579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGH8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGH8"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="568" mass="62440" checksum="9284329EB14E9821" modified="2018-07-18" version="1">MLLDRNDIDPDKADDWSQTPLSWAAKNGHEGVARMLLEQNGVNPNRADTIYGETPLSLAAKNGHEGVVRILLARCDVNPDTADSEYGQTPLSCAAENGHAEVVRVLLERDDVNPNKVDRWDRTPLSWALENGHEVIANLLRKPPDPILKHATNLQPTESSSPELSNLSEPLPKGSTGFDIQGQYPTLPSLPTSHILSAAEPPDRSKIPRPPPTVLSQGPNSNFQEQEYVQATDFNGSTAIAWAAGRGHEGVIRVLLQRNDANPTTADTIYGQTPLSWAAKNGHEGVVRILLQWNEADPDKADKWNRTPLMLAAQNGYEGVVRILLDRNDIDPNKTDDWSQTPLLEATKNGHKGVVGALLEQNKVDPNKADKWSQTPLSLAAKNGNEGIVKMLLGRNGVNPDKADDWSQTPLSWAAKNGYEGIVRILLRQGVVNPNTADTIYGETPLLLAVKSGYEGVVRVLLERNDVNPDTADNEHGQTPLLCAAENGHVGIVRALLERNDVNPDKADKWNRTPFSWALENEHEKIAELLQERVGLIPKPTISLQSTESFSLEQFRLLEPPSKKIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGQ7</accession>
    <name>A0A2T6ZGQ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1157368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000282">
        <property type="protein sequence ID" value="PUU74659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGQ7"/>
    <dbReference type="OrthoDB" id="5416164at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="241" mass="25821" checksum="2891FB09DB56D897" modified="2018-07-18" version="1">MFVAGYNSSHHCPPSPQPEPTPPISRTRKRKKTTPTMITNLHTVLPLLILTTTTLIPPATASTILKREVRQLPDYRSLTSCQKVCIAGTPGTLTDKVSLFYLTKCEAKACFCPPQNEPQIGQDAQKCLETEGSGVCATVEEYNGLMAFVAKYCGFEYVRATTGLLFPPSGGARTTSTLGATATRSCWDSSGYPVSTAGCSSSIVALYLLTFSETGTGKAKADSAWEQLLGSRYLASSCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHF0</accession>
    <name>A0A2T6ZHF0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1091481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000261">
        <property type="protein sequence ID" value="PUU74920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHF0"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="52" mass="5983" checksum="07DFC80D62E7CCED" modified="2018-07-18" version="1">MARFLWRIREYHTSDISCGMFAGTIGVRGLLKLFEEVQDGCPMKWLKGGTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHV7</accession>
    <name>A0A2T6ZHV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor Pcc1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1091209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHV7"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="11573" checksum="0090EF30B649B6D5" modified="2018-07-18" version="1">MATAAITASPADPQYPHSLTISLPLPSHHLADTIQRALSVDREISPFVQRTYTTLPDSPILQIHYKATTARMLRVATNGMFESLGTVLRVCEELDVDVLEKELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI57</accession>
    <name>A0A2T6ZI57_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1054470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI57"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI57"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU75171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="354" mass="37955" checksum="59860466DE161EE0" modified="2018-07-18" version="1">MDTVDASAHYSQSIDEKPSLLVLILDTNPYAWSTLSATLPLDRALASILIFLNAHMAFSHANRVAVIASHTKSARFLYPTTTTTAAAGGSGGEDPFRDANKYRQFRIIEDQVQASFAELMRQTTTEELVDSKETMMAGALGLALGYINRLVRVDDGGIGGGIGGGGGEVISMNARILVVSVSGDLAEQYVPVMNSIFAAQRKKIPIDICKVAGETVFLQQASDTTRGIYMQLEHPESLLQYLMMSFIPDTATRRHLVPPTQINVDFRAACFCHKNVVDIGFVCSICLSIFCTPPEGAICTTCNTKLDISALGNFGGSPAVVSTKKKRTKKLKQSKATSFSNEASATSTPGTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIM5</accession>
    <name>A0A2T6ZIM5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIM5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIM5"/>
    <dbReference type="OrthoDB" id="3351042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="434" mass="47978" checksum="B8844254ED828F2D" modified="2018-07-18" version="1">MLAPQHPQSMQPTQPMQPMQPMQPMQPMQPMQSMQPMPYQPPPAKPGKGKKKQQQQQFPKYKDEKKTGTAKRFLGDTLAGRFVRSAVQTASSTWKLPESLSPWGDNNSLTLPNVRYRDAVLFTTFAFVGGPLLEAGGDALGGVIGCDTFAAEIINPVVEYFVYNTVAKYALFQIIEQAIDKGLLEHILPEEEKMLRTTSMRTLQCVVKHKLMDVDADLRLAGVTPSQNALSCEKGWFCPYLFASSRTPIIPRSQDFTIAQCFGPFLAGDYQLAHKLLSESAAVLSLCNPDPTVNIGVNRVLVTFIGITPYRGGMWSSSRRPGAALMNFHLLNGCPSMVIPVNNMAPIVAWSPTTLVSIKKPEFNPEWWHGQVCEFLDSIISIKDCVPGIRANYERALGRSTSMVINGALGLRDVQPGILKGLDPERAGIAFFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIU9</accession>
    <name>A0A2T6ZIU9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000233">
        <property type="protein sequence ID" value="PUU75420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIU9"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="31706" checksum="F2284EA259D5611E" modified="2018-07-18" version="1">MPNSRRTPNYPRDNNNAFNTTGSSNHNANAQNYNNNVFNRNNNHFNANTIFVVMNTSNEIEERSAREIARRISETLSPPFLAAPPNPDSILQEATIHQHQEWLQATTDELSLEGSPGATLERINAQGGRISGVLLTDSIQSPNMGMPAAPPISHTMPSAYLLPGSSLPSAIVPPMDDPEKETIIAVQVKAISLGKSPVFQISKWAMLPTAVHSYFFPYRLTKITLVDTPSFGNLMMSDYEVLAEISAWASSAYTKGRLLPYFLMKFANPVPGCVTSGPVIFKLGMLNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJB0</accession>
    <name>A0A2T6ZJB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette sub-family e member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_339294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJB0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJB0"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="128"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="403" mass="45576" checksum="5A9528F39FB0DC13" modified="2018-07-18" version="1">MEAMIDVLDLRPVLDREVEQLSGGELQRFAIAVACVQKADVYMFDEPSSYLDVKQRLKAASTIRGLTRPDNYVIVVEHDLSVLDYLSDFICVLYGKPSVYGVVTLPASVREGINIFLDGNIPTENLRFREESLQFRIAEAGDEFMVDRSRSFGYPAMDKTLGKFHLHVDKGEFTDSEIIVMMGENGTGKTTFCRMLAGVEAPDDSNKIPKMSISMKPQKITPKFPGTVRELFLKRIRSSFLNPQFQTDVYKPLHIEDFIDQEVKHLSGGELQRVAIVLALGMPADIYLIDEPSAYLDSEQRIIAARVIKRFIMHAKKTAFVVEHDFIMATYLADRVIVFEGEPSVDATATAPQSLLTGCNAFLKSLNVTFRRDQNTFRPRINKLDSQLDQEQKLSGNYFFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKD0</accession>
    <name>A0A2T6ZKD0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_992354</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKD0"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="252"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU75950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="740" mass="80381" checksum="0500B4BF83F3A813" modified="2018-07-18" version="1">MMRQRVLRSLKPSGRLLATLPAARRTFASAPPASAEVEITIDGKKVKIEAGAALIQACEKAGITIPRYCYHEKLMIAGNCRMCLVEVERAPKPVASCAWPVAPGMVVKTNSPLVHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRFGADRGRFHEVGGKRAVEDKNIGPLIKTSMNRCIHCTRCIRFANDVAGAPEFGSTGRGNDMQIGTYLEKNLDSELSGNVIDLCPVGALTSKPYAFRARPWELKPVESIDVLDALGSAIRVDARGMEVMRVIPRLNDDINEEWINDKTRFACDGLKTQRLTMPLIRRDDKFVPATWEQALAEVASAFQKLQPKGDEVKAIAGHLVEVESLVALKDMLNRLGSENLALDQPLGNQPPVHGVDIRSNYLFNSKIFSVDDADAILLVGTNPRHEAAVLNVRIRKQWLRSDLEIGLVGENFDSIFDIEHLGQDAASLEKALAGAFGKKLLAAEKPMIIVGSGVTEHTDGKAFYQIIGQFVDKNANKIITPEWNGYNVLQRAASRAGAYDVGFVTSSPTISQTTPKIIWLLGADEITPNDIPKGAFVVYQGHHGDVGAQYADVVLPGAAYTEKSGTYVNTEGRVQLTRAATNPPGVAREDWKIIRAASEFLGVTLPYDTLAGLRTRMEEISPALTHYDIVEPASLAALGNKVQILDANKGAKTNRAPLGRAIENFYFTDAISRSSPTMSRCSAAKMARSGIEADPDPGEAAYAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL56</accession>
    <name>A0A2T6ZL56_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000197">
        <property type="protein sequence ID" value="PUU76186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL56"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL56"/>
    <dbReference type="OrthoDB" id="2529286at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33148" checksum="E2A60F96EBEEDA0F" modified="2018-07-18" version="1">MPLNSFLSLLHEVHDTYEGSLTPPPRLHTGHTGQSPTLLSSSRSGGSGETTGAVLWKVTPLFATYLSHPGNPFFSHGVLSSRSTVLELGCGVAGVLGLTLGSSGRVRGYFLSDQEYVLKLLRRNLEENTPPPAAPRKGRARAEGSAMVRTLALDWEKDRITREHPVLKEGVPFDAVIACDCIYNEALVEGFVEALEEACLELSAASSPSSPGAARGREGGSALSKEAGGEGKTKPTLAIIAQELRSPEVFETWLVRFHKSFHTYRIPDSLLTPEINSASGYCIHVGILRDSGQIGMLGRGGDQKRPLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLN8</accession>
    <name>A0A2T6ZLN8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1088369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLN8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLN8"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="282"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="583"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU76407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="830" mass="91306" checksum="5B8464555D677549" modified="2018-07-18" version="1">MINSPRVPRLRRSGGHEYAPSPLRPSPMGTKIPLNDDVAEKAKRFKKRSMLRGLQANEIVAAASPARRQTIGSTDDPTTPRNLPALRGGVAGEGPIDAVTPMRKVPILANFEEWMKLATDNKINATNSWNFALIDYFYDMSLLKEGEGINFQKASCTLDGCVKIYTNRVDSVATETGKLLSGLADSNSKRKDRDGEEGEGSDDEAGEDGEDGEGSKRRKRKSQRSSEATLAKDFASLQIKKHDLELNVDPLFKKATADFDEGGAKGLLLNNLSIDSSGRIVFDSSDDSGHVDPIDKEDDGIKKEDEDEEPKEPEPVEEDKVEIDFNALRNKFFPNLSILDQQDICPSLKNFDLGDPAGSLDIPFLKALEERGDDGDVLASDIEGPDGPIGDGDLTERPDMAFGFDAGFGIGDDDDGDMGFGEGGEIWANETIVDAAQRFMSPAKRPLLGLGGEGNEDEDTKDFTVGFGGGGDDILSYFDETLKKNWAGPEHWRIRKLKDNSKPVNAPVRQRKEKETFLIDFMSPEAEVTDDVVRPKKGTASINMPKKDWKSKSRNLLPDDKHFNSTQLKKLFLKPKAVLYATKSSKTTSGGKSVEDRPEDMDEEFWAREDMAKNIQASSTPDPKVSGNYDANFFSDEGLGIPGPADDDDDDFADAREVFSPPPDTLPQGAQNPTAPDPSPLNALLAGGGATQGVEFGSQLVTSSRRVRPEYVQYAKIAKKVDVRKLKEKLWEGLSFSDTKKEEHQDAGKENAVKDEEMEDVKAEERKFTQVINGLQEVYPQKAMADISTSYCFICLLHLANEKGLVIEGNKTLSELSIWRDMTAEGMDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLV4</accession>
    <name>A0A2T6ZLV4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_990530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000188">
        <property type="protein sequence ID" value="PUU76468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLV4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLV4"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="565" mass="63418" checksum="4F4B9936DF21224D" modified="2018-07-18" version="1">MDIGVPSVRNLFRIKLERMILWIAIGITSIPLHLLYNSAVYTSLAANNFLVTLVANNHFEPGAYSNTAGVDHSFREISRNATTGKEYGDIGYQTDSYEIQLLTSMLEGHNASTPSYEDLTPSQCTNLYKADFMSNHRNLFLISNYTSADTHNNTILDMTIVMGDEMSSNSWICYWQRTSIDGNDRHTTPQCNPNEFSSNMAGGLPWQMNLTSVGVIEITGCKSEITNEKCKVQFSLGIMIAVICCNFVKVCSMIMTIVRAREPTLVTLGDAVDSFLRTPDPSTVGICFADRRFIEREWRRGWKTGPRQWKQNAVQRWWTSVSKTRWITCNFCFAIIMIAAAVLLRLGIRNDGQVWNTDLKSMWSRGFGKVNSVSLIAINSRNLNITQASLLANLPQTILSFLYLTYNSLFTCMLSGHEWSLFGHHHRTLRVTSPRLSQRSTYWLQIPYTYAIPLMILSGLLHWLTSLSLFLARVEISDPFGREISATKSTAGYSCIAIIFVLTLGILALLIAAGMGYRPFSAEITTVGSCSAAISAACHTWGADSESIIGRKVRWGMWESYRIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLX9</accession>
    <name>A0A2T6ZLX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_990390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLX9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLX9"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="7">
        <location>
            <begin position="32"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="14457" checksum="0E8A2F461602950A" modified="2018-07-18" version="1" fragment="single">FPPSSAPEQLEEMELAFSRNRIVTVEVANGDFTFVKTCTQPFFGTGMIEIPPGGIKRTKNSGKMHLVFYLLKGKVQVHVGETMFRVRNGGQFMVPRGNLYSIENPYDVQAKMFFAQGCEVEVQEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMC1</accession>
    <name>A0A2T6ZMC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMC1"/>
    <dbReference type="OrthoDB" id="5344687at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42089:SF1">
        <property type="entry name" value="YALI0F09427P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="18068" checksum="731719892EDDE47C" modified="2018-07-18" version="1">MHDHRSHSLLQQLPLTVSPFIHLPTAVTLPYSYQTLPLSLPPPSTAPPPGNPQGGYVVSPSGSFSTTPAAIMSSCQSLITHIQSQQKAKEQAIKDWEKSIEERELMEKRRVAPGYLDTELRILEPTRSTPAPASIPAPAAPAAAPPVQDRASGGGEELDRVFGKLGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMG2</accession>
    <name>A0A2T6ZMG2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1066436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMG2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMG2"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="548" mass="59832" checksum="3240D5D22D81A608" modified="2018-07-18" version="1">MSNSGEGGGEGGGEGGGGGGGGGPVPPEISPWARVKKHIKEYQWIGAFFTLLSGVIGGLIAAYANPQGSIPIQLTINGVEGTALICVGSPTLQTFPSLLSPIDTTTAITDTGTTMAAIPAILSPIYTIITSIDTSTTISTTTSTDTTTTTHTTTNTDTTTTTKATTTTSSTTRTTTTTTTATTTLPGTGGTVPAWVVRELEGTGRMLQDLHARLISMANIGQVEEESMKGMLMEVEAQQRNFFALRKRLIREFKKPGDESHITSKSSSTSPQFETQSTLISDEHKLQYHSARELVKTIEGFLDLVFNDLFIYLDGISDSEYEPIERELRRAGLREMVRFTFENASKAAILRISPGQERDIIGARFAFEFFRKISSIPGHHKHSVLSLRSTLFQVPGIRSKEGDQCFQPSTRSGEAWPSVMMEVGHSEAMYALRLDAEWWLINSDEQTRVVILLNLQKEPFTLHIESWMMAPSGQEENGPQIPYRVPRCVQDFHIDKAGVVTSPLGSTELAIAYNSVFDRPSLDKPPPPITFSFSELSDFALLLFKYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMY9</accession>
    <name>A0A2T6ZMY9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hsp90 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1102148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMY9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMY9"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="704" mass="80078" checksum="622E96578141808B" modified="2018-07-18" version="1">MAETFEFQAEISQLLSLIINTVYSNKEIFLRELISNASDALDKIRYISLSDPSALDEEKDLKIHIIPNKEAKTLTILDTGIGFTKSDLVNNLGTIARSGTKQFMEALSAGADISMIGQFGVGFYSAYLVADKVEVVTKSNEDEQYIWESAAGGSFTIKLDESGERIKRGTKIVLHIKDGLQEYLEEAKIKEIVKKHSEFISYPIFLHITKEVEREVPDEDEEEEKTEEGDDKKPKIEEVDEEEEKKEKKTKKVKETKEEEEELNKTKPIWTRNPSDITTEEYASFYKSLSNDWEDHLAVKHFSVEGQLEFRAILFVPKRAPFDLFETKRSKNNIKLYVRRVFITDDCTDLIPEWLGFIKGVVDSEDLPLNLSRETLQQNKILKVIKKNIVKKTLEMFNEISEDREQFDKFYTAFSKNIKLGIHEDAQNRPALAKLLRFNSTKSGDDATSLTDYVTRMPEHQKQMYYITGESLKAVSKSPFLDALKAKDFEVLFLVDPIDEYAMTQLKEFDGKKLVDITKDFELEETEEEKKLREEEEKAFEGLAKTLKEVLGEKVEKVVVSHKLVDAPAAIRTGQFGWSANMERIMKSQALRDTSMSSYMASKKTFEISPKSPIIKALKDKAEEEGGSKAVASIATLLYETAMLTSGFTLEEPNAFAQRVNRLISLGLQIEEKDDDEEEEEPEPEAAPAAESSAAPESSMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN82</accession>
    <name>A0A2T6ZN82_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN82"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="753" mass="85336" checksum="900A0D7FB4857D86" modified="2018-07-18" version="1">MNCLTPICRRRRGFLRLLQLNSCYSYRFHTKRRLLQDIPKSDETRTPSTTPNNSYTNTAHNIKLDHTISDVTRLAELRARIRANYAPHPLPFQAGTPDYCYLRNKGLLTLEDVQLVTRELVIAALVRQRSSSGVSEDLIGVAHTIIRDIQAGLLPSDYLVSGYLIGVLRVSGTLEDLMRYWNWLVDHGRKSCTVQTFGIMIEALTYRGTKLSIMEGMYKEAVKRFYEPDHPPRSRMLTQGILAARVLNGNWRGAYELYDYYLKLYPQSESREYVEGLLMFERPPNEAAIIAIICCRVGMPMAPGMIRIILHGIWINYRDVRSMLTVATAYTGAKGEVNGSLILRLLVSIMSSASDGPLLTLGKRYQEGYNFIYQQIDKFTAVARSRGFLFAPPKWTPLIDVAGGLRRRDMLEAVLRVMRDMKIEFTSRHLIAIGYAYSAIGDINMVVKTWKVLREKFPMSASKEHLMHSLTACGLGFRDAERLQNSKMSSSDILKAADHALSNPRRKAAPPPPGVRFACPLVGNSKISLEEMREDVQKASAKFLAAIQSYGEPYEFSADPDFSTIPSKLPAGSSPPPVAREELESYYSTLASLGAAKPGEVDGSTGYTTEHLHFENWRSINQVLATAEENEERERSAQREVRVLDFSTDSLLLHVGEEDEEHIWHRVRELDNRFYLEAEAKERIGERKKKEVEQDEDDEADEEPVDAVHRRKMLHSRANLWRQLGIENLVRDLGKIPLAGGGQRGGEDDDERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNA0</accession>
    <name>A0A2T6ZNA0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNA0"/>
    <dbReference type="OrthoDB" id="2435973at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="277" mass="31295" checksum="39E8AFF435909F88" modified="2018-07-18" version="1">MDSSSGFFDFIFSDNPKDSKAAYESLSSRPYQIFDLLLKEGRFTNFFSRIDIYGNNLATLLSQFPSFEQDDYSASLLREMIRAFALSLLAERLDDMRSRSAVARIVLSVVKLSGLRRTLGRFGVRLGALPGILRILIAEGHIKKLAQTHKGCFEDLISEPQAREKWAEFIMELCRECKEHGSKPSAQELAKFIRTVPCEFCNSNVSFDCVLNDGPEGEPTRARGPSFGLNMESNVFKYLLGEPLGPWKIVLSQQAMEDLGTENAQSTRSIKERFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNS8</accession>
    <name>A0A2T6ZNS8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1086785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000161">
        <property type="protein sequence ID" value="PUU77141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNS8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="52" mass="6358" checksum="AD17B954278C1A92" modified="2018-07-18" version="1">MDFWKVSAGRGLRYYLYLNFGFRSRRYLAFPSYDFKSLFGAQTWKSPFDIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNX9</accession>
    <name>A0A2T6ZNX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_987596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNX9"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="385"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="531" mass="58787" checksum="CFBE3C72FA343149" modified="2018-07-18" version="1">MSLPPQTIRIKRPRDEAPVQALYIDGNTRTPQKRQRTGHSPDYVFRLAHTVTSPTDPTPRPFQPRTSSPPRRYGVPQVRSTLPLSSEPVSLPSPSSPSTVLPLTPLKPRNTSTATTPQSGEKLVLDTATATASQSALLKAPVPLSAISSNGGSVLESQTVVSPDSPPAPSPVQTPERHDPLRHDTFGSESPRAGGLTPAVKRKNGEMERGQGDEDEERSGTKRKITPVRRYQLAKRLRVKHSHHPYSSATRRSAIFTRVAETSDTNTGRAGETGATDITPGPVVERKRPRTHPEEKKKLEEQKREAEEEKIVKGKEVKFQEQEDDNDPLIAPFHAMVLEHLNSSSNDGTRNLPSPPSLAKLKTTTSKIGGGVGGGTWGALEEEDGFVYDVYIREELPASIDKKEGDYGVLVIEGSDDEEWWYEGDPDEGSEDDVWASDDEDSNAEDFHTNDYPEEPVYDSEDDLPRRFNPSDDDTDDDPNVFKPWIRGGQRFGDEEFDLDDNDDDEGEEGRFRIKRGIWDIVGGDEADDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPF3</accession>
    <name>A0A2T6ZPF3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPF3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPF3"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17222" checksum="2BB386047A29641F" modified="2018-07-18" version="1">MSWLHLAVGSGLAAAFNGLFAKLTTTVLTTSLSSSIARLFSLPADSKIVEYVVRGMFFGLNLLFNAIMWGLFTAALAKGPTATKVSIVNTSANFMTTAFLGWAVFTESLPPTWWLGAGLLVAGNVIIGRRDEKEKDGAYQAVATDEGELRTREGSAERKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPN3</accession>
    <name>A0A2T6ZPN3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPN3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="106" mass="11929" checksum="9F06EAE8BFC86215" modified="2018-07-18" version="1">MLTNFVWILDKGILKLNPGPIIAASSMIVASSPWGQTTAEMIERYYLRKGDAVHEEMRILRKAPDEDLRRQKETLEVRILQKQLDKMEEAEKATAESSPAGKSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPS6</accession>
    <name>A0A2T6ZPS6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine carboxypeptidase S28-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_986925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000152">
        <property type="protein sequence ID" value="PUU77476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPS6"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000636">
        <property type="entry name" value="Serine peptidase, family S28, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF109">
        <property type="entry name" value="PEPTIDASE, FAMILY S28, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754494" evidence="6">
        <location>
            <begin position="18"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="548" mass="60550" checksum="51F0670A0DBC2C0D" modified="2018-07-18" version="1">MWKRPVVGLMLLGLAEAVIPPGPFFGFEDRVDAEVGRGPDDGNLQTFPTTQAATVLAETLPLDHFGNYPGTFENRYWVLGQFYQPGSPVFIYDSGEGNAEPNVQSRLVSQTSFFRQIVQEFNGIGILWEHRYYGASSHVNISRTTPMEEFRWLNTAQALADIPAFANNFTLSNFSSIDLTPASTPWVFIGGSYPGIRAALVRKKYPETIFASFASSAPVQAQIDMSVYFDQIYGGLNALGFKNCTNDIVAAIKYIDDQLSKADTAAAIKKQYLGVGADNNSNEGFAEALTYIYNSWQSYQVEGTLASMRLFCDWISTNPETGAVSGEEGWAKSKGAKFTSDRWATWPQFGALVNYYAPTSCAGYYGNSTVGSPNCRLDDPSSSPAVISWAYQYCSEWGFFHSTNLGPNQIVSSYNSLKYQQDICNRQFPQGISSGLLPQQPGVDKINQEYGGWGIRPSNVFFSGGEFDPWRTLSLLSEESWAPKGVKLTQDIPEEGVSTATDEVFGYLLKGASHCFDFQTTWSDGANSRNIFTTALKKWLGNFKKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ99</accession>
    <name>A0A2T6ZQ99_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_148938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ99"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ99"/>
    <dbReference type="OrthoDB" id="10459559at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="370" mass="39401" checksum="2FDA0593217CC8AF" modified="2018-07-18" version="1">MALQVDEDWDFDTIRTNPHSTFRHQGFETIRGGRSVSNSSHSSDFDEIPISVALQSLALNSAPHSENTGPSRRVASPSPSPSKPTRAGTARRRSPPNASPNSARREQLHHHHHHHRHITKESQVLHNDPSRSPSPEPQSHTAKSTSTVRPVRRVSEKNNRPGNATTSSSTSSSSTPSTGITSQPSQPSQPPDAQSLYNSIIHTSLAQLTTNTSAAPQEHLAAARLSSAWSSLNEVNPEASILLLRSMLDQLQRNPALNALVSPTSQSPLSPRPPPPPPPTARKATPAKAPELLSSSPAATGSPLARRKRRSSVVSGAGAGGAGGRRRGGSSASVGMEETAEGKGVNAVLADVLYGRWVEGLRERWGSTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQI3</accession>
    <name>A0A2T6ZQI3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CPAF-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1065636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQI3"/>
    <dbReference type="OrthoDB" id="27214at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056186">
        <property type="entry name" value="PDZ_CPAF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052766">
        <property type="entry name" value="S41A_metabolite_peptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049">
        <property type="entry name" value="PEPTIDASE S41 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37049:SF4">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23658">
        <property type="entry name" value="PDZ_CPAF_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015500037" description="CPAF-like PDZ domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="CPAF-like PDZ" evidence="3">
        <location>
            <begin position="209"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="747" mass="86447" checksum="D9690314F30EC23F" modified="2018-07-18" version="1">MWLSSMAVSAAVTWIFSTVVSGLAAWPEVGAEGGVYIEPAPILPLEKRTTQGQDPCTYFTQNYGRITGEDWRKCILAVPFNEPFARQAVNAFRVIFDLESSTEYHENPPPELELPPFSLNATFDMIEEKINSKGYQNHWSFEYDLMVLFNRYRDGHTSLNTMCMHGYYWVHAYPIVLFEEEVKGKKVWEAWTVEKDWNAKNWQAAKLGDKLVMINDQPALEWLAQYTRMSMESFAYVDPDSRMKQMEFTVPTGLSRGMFAKRQMWDGEELSIQWANGTRRNVPWTIQFTSQMVMDGKFRFNNVESLEKLCFLNTTEMEKLILPQPPPRARRRSEVTRLGEILIEKSAPVLERRSIDIRKRQEPVVVERPNGYPPARISGPEFAVESFILRSDPETAIIRFGTFKEQNQNTFKEFSKDFQNFIAEELVSLKKDGIKRLMIDVSHNGGGQAVLPYDVLNQLFPEEQKFSSMNIRWSPTTWALVQNMDNGKYMDYYKDENMKDFKSKEQWLGPLFRDGGWYSPKWKQDFEQYAQEASSIDLNHTGPQPFETENIIAASLEEHGVRAVVYGGRPNSKTPMQTVGGTKGGKMIDMEQIYQSLAKAVSDKRYTDLPPSVWMPPPMPIRVLKGSLNLENKFRDGIDIPLQYLYTPACRKIGFNKDMFVDIMVLWEKAREVMWDEDGKPIKCVDYSTQIEQIRAQDRAKQQKTQAQAYPRPRTQQGPPQGSQQARAVNISRTYARHSYMAYRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQZ5</accession>
    <name>A0A2T6ZQZ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQZ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="492" mass="53467" checksum="CCAB5A0B62F03178" modified="2018-07-18" version="1">MPPSPGGDSYRPRSPFTPHPTWDSYRSDSSRFANSRAATNQPVTSRAEDPVSSWDRSPFHRCCQGTSDEPGVGRVTKKPLPDRRDRNSIPSSQRFRDGNNRSSLHAGKGIIIEVRNGPPGSSRACNPPESSLTHTRDFSKFSLTIDSPRLLAESQNLGQPTKEFSWLGENNSVTSSARSQPDTNVPHPRGREGSPEDTSYSSGSRFLVAIAFAAREKGASKPDSAPNTDPSDSTWRTTIFTRSIWELVHGRAQQAKNCPTAALLPQNVPLFGSKISASRPGHLRSRKAKFKGSLEEYYQMLSDKEKKEHDDNPTFPTGSREDGGPTFSSSSEGEDYNQTSLKNPGCLDRASPGLSLSSVLNDSTNNTRPIEAKKDSALSKAQQEDPPKSEAQAASENAHLTKDTLRAGSVPNRSTHSIAPTRKLVIARGKQLRPELVQAMALLRASTSQSVHPEHECGKGHLPLASEGTPVTTLEISSCTSEKDGIPEPPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR25</accession>
    <name>A0A2T6ZR25_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1144196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR25"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR25"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="14155" checksum="8889214DFD3C0390" modified="2018-07-18" version="1">MRSKFKDEHTFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPADLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGFEELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRC5</accession>
    <name>A0A2T6ZRC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1084880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRC5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="12968" checksum="AFFF78D6EB0A2263" modified="2018-07-18" version="1">MKLSSRSFSCSFARGLFLWLGCYRCCCRATHSQRLLSRPHSLLSLLLPCPALPAFLFDSIPITFSLSSIPPTRIPSTSLLQHKALSIFHHLHHPPPKAPSTSSATITNSFPHPLTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS75</accession>
    <name>A0A2T6ZS75_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_88516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS75"/>
    <dbReference type="OrthoDB" id="5318005at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="16165" checksum="C3A6779DFF831EC1" modified="2018-07-18" version="1">MYLSTVMTAQIPDVKPTLFGLSSPRSPTKGYTCAFPSWPSRPCLDRRMPWEDDEDEESHECDGRKDGRCTCPATAATAEPSSSSSAVERWDGRSVSSTCESSTSTSTEGKVEALITGFEKLPLQPRSPKAPSGQTRSLLSLAILGKTGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSJ9</accession>
    <name>A0A2T6ZSJ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1101327</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSJ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSJ9"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="656"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU78465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="869" mass="95236" checksum="3DDBA827541450DF" modified="2018-07-18" version="1">MPGILPMKLIKCGSSQTRIAQACDRCRSKKIRCDGIRPCCSQCANVGFECKTSDKLSRRAFPRGYTESLEERVRCLEQEVREMKDLLDSKDEQLDMLSRIHSFSPYSPPASAVSGGSYRAHKSPESARSGSADFGLYDTFVVHEASSLVGGSEGDGNGVFYVGSSSGRPFLELFKKKSGVDFNPDILFESRLSVKPSEQSNSHEDTIKAPARLLSDHLLQSYFQEYHPLFPVLHRPTFLASYEKLVSGNGSQVNTLPHHSVAQLFLVFAIAQQSEPRNGPDQQFDAQWQRSLNAIIVDSTIETLQCLVLAQLYCFSKGDYSRLLQYKSLAVGIALRLGLNQSQRRFTLGALGGEMRKRAFWCVYCLDSFSAAMLGLPKLFKDEDIDTEYPSDIDDEYVSEKGFLPTLPGDSTKISSALALFRSSRVLSKVLDAVYPTSSSHEVSYAKLKELEDELGAWKAGLAPHLRLEFVNGTPATNVVDSRSPLLVLAYHYIRSLIHRPIIGSTLDSKVSASLHTIRESSKCIIQIIQLLTERKLGFSFCLDKTQLCLMSAFTLLYSTVDCPQHTSLAKENQRLITGVLEELENCHPPMAKKLRPIATAVINIEPRVTTTNRNQHEKPKEHIQSPLTPPLVSPTGQGPLRKKLSSISAEFSLRRGKNGDIRRASSQDMSSMGDHGNVRLTSASLSDLSPTPRTRYPAAGDAAAVKILQSRQNLMTLDSPYFDGLWDMGSNDLHSDSQNPPSIPAYAWDRMLAHAHIYGGEDVGSGTLIHPSDSLSAETGTRPVDQHWSLSETPTAASFHGAPPSISSFSTLSEESLTGGDDVRAGAGDLDVGSGYPDSDNLGDFLGPLMGARGGGSGGTLLEDEWHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSN2</accession>
    <name>A0A2T6ZSN2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1142457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSN2"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12378" checksum="E4500AF614B5F1C2" modified="2018-07-18" version="1">MSCPYSLPICAYGEKGKVDDKSTCTSGEEHFSDIAAAYRTELEILYDAGYRDVPVDDPMSVLILGLSYSTNFWILKVEGGCNRGSVSFDRAQILDAMVVNHQLTPWYSKGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSX1</accession>
    <name>A0A2T6ZSX1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1083671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSX1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="17084" checksum="C8739F982BBD9EE3" modified="2018-07-18" version="1">MGQAPSTMSSSEFITIYANLLLALAAWGITSAVMIWQINKHANELKKELKALTKELKKEFKTNFEEPLSSFMTAIRNPQGISPPPAYTTMKCLPGESEIIAKLAEDIAERFLAKMEEDITKSVVPEANIEAVKAIPEARDGDVSQGQATNSVELVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT89</accession>
    <name>A0A2T6ZT89_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_41447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT89"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT89"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="414" mass="44476" checksum="2ABF768317871720" modified="2018-07-18" version="1">MVYNTRRKSLSLPSLGIHLPQSSRSSPSSSATKSEPPQKRVKRDHSPLSAGGYDTIRRNNLPPSPPPECRISHEGINDEIVSGVVDVLERSGNRPHTVKELAAVLAPVLGVVENSANPHAIISSRLNTYLKRPSSSSSSASNQCVLSKELITTHPKRIYFYLSALPHQPIPNSHHPQISVASPIPTTPSTSDTEDPDVEENEDLCRRREFSPSPEVDLDFTSHELSPPSPVPSVTSGTTAASASLSGSKSALSSPPLEGDEQEFSQSAIYICRRSASRETSNPPSSVAGEKRNRGEYEADGHGEPGGDGILLGYSHAVVSSAVGGVVTGVGVLDSSSGLAHVKREDGEDDEDDEDIREGRVEPRDEEVTEVERTREESEKPAGLGLGSWGGEFERHLGSPESVELDELDDLFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTD9</accession>
    <name>A0A2T6ZTD9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_43363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTD9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17866" checksum="5ECD77EFBF2D58D4" modified="2018-07-18" version="1">MYAQYATIHETKRNGPLCFSLSLPLYHSLAIFTGEGGSPGGSLPVVAVAISLFSICLPRFIYLPYLYHTVLYPLPFPPSLPPSLHHLSQWKNIIPTTGTQTNARFHPSIHTSILFNSLPPSLARLRRRRGDHMVFFSFFYIYIFIYLFIYPLSLSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTI1</accession>
    <name>A0A2T6ZTI1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Piwi domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_36182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTI1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTI1"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="78"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="246" mass="27383" checksum="D6A32AC537EA84BB" modified="2018-07-18" version="1">MGFCSRQCPERGHTMRVDERGIDTFTKTCGQQFSSYGVASNPRCSCQWAMANPQGDFQRQIHELISKLQTSNAVRPNLLIFILPNAAVKSYCTLKKICDTTFGIASQCMVLEKCFNLKGQLQYLGNIALKVNVKLGRSNTVIEDPFLIKQPAKIMGYDASHSSPSQGRMNPPPPTFTAISASYDRRCAKYSSVTSCQDAGQEVIQDFGAIAEELLKRFQEQAKRDPAAIIYFRDGLSETEFDKVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU01</accession>
    <name>A0A2T6ZU01_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000103">
        <property type="protein sequence ID" value="PUU78960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU01"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU01"/>
    <dbReference type="OrthoDB" id="5598852at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="360" mass="40810" checksum="AD0345AC9718D5EE" modified="2018-07-18" version="1">MTKFIYSDSDLRASLNTGAKQNAKAKELALSHLNIRAMKARSVDIQGFFSRTLIVTTESGKIIVQLRVEPLDIDIFRRARQALGDVVPDIAKIRDEALEREEIWPYYMTFIPGRTWQRSAAFCNRALNVTCAKSLGRSLSHGFSAMVDEENRPRANQIKPFREDTQRLLDNSDQLKTLPLFISHADLNHVNILVQEDGEVSGIVDWELSSDLPFGMGCCRIHDLVGRFTVGEFHMPEGFEDAERGFWEAILDGIPTDVRRVLDTNLYAVQTSIHIGALLDTLDIQSDSFNLAGLKALPKFLTYRIPALRGQEPPYILGERSQNMEMCSLLAHYDVNPLHNATYSRKERLAKGRVDEKREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU62</accession>
    <name>A0A2T6ZU62_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000103">
        <property type="protein sequence ID" value="PUU78944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU62"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="270" mass="30313" checksum="74F3FA8054652AC2" modified="2018-07-18" version="1">MAEEVTSSHHHPYFLRSFRSKLHTLPRVEGQYRYYIKTLAHLVPVMDIKCTACITSFVFLIPPPFPHSFLESSPVEQRTCLGDAFVVNPVLWSSSGQDIAVGRFSAHAGDALGTHPHEPVHYWYTRASIARASVRQLLHRPEANFHTRQAQLEAQAQSQAHAPTPSVPYSSTGYQRYRSISTRLIGYRPFCLTRQSLNPTGSVPLPSMWTILAPHACSVTGQRGPDQDNGGRPNQDDLPTVYGYNTGSRREKELGVFVRRRGGYDLAKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUG5</accession>
    <name>A0A2T6ZUG5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1082466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUG5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUG5"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1131"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1203" mass="134559" checksum="F9487F6BC76B9AE1" modified="2018-07-18" version="1">MSHKTIFCPEPSFYAIGGTVASCLTQDLPPEEPARVLSLGCGDPRSILFSVQCAKMDFDYDFTCCDIEPGVLARNVILLALIFEGNKSEARNEKLWNIFYHIKLDRESLSALLDQCEKLVSVSVDISSWNNSRYGSFMRMCDKRTLSKLRAQWQTYIKNAKLAGREKKEYDEKFTKALNGTILKVPKHDISSTLASGPLTMEAVESTQSLLRHYWTKGTYSMDPKVIATATIPNPTLSHSFSGKILALYFRSDPLLSIHTGPAFCGLKSAPKVYKKKVEPSHVVKVAKREFFEWVKSFKDALTNKKNKLTIRFFNGDAMSFCKALNYCRVQKSIDTGYYVAPWTTSLLRLDGGDYNEDSENKAPVMFNAIDTSNLADNLGLINLLLITTPLLIRSPLSCVYSETKFRPGDTPINALSDRICGDIPAVSLLFDLAPISYLMHVNSRSSTHAVLLTLVGDPKGGCDGTFGERITWKLASLSDPLSVKVDGIQTKILEYESTQLAHFVFGIYQKMFKPDEHMRDIDLIHYTRGTLVLLLKLVKDRVKTDWDDFMKQFNELVVGDTNLSLGKSNYQELAAQLHVMGLHTFDFLGNYRQAHPDAQANVGVFKDWKDVPPVVCIVLTVSRGALKPLIETGGGAGNPFLHCETWNRGGQNYYSCFHPVFGKVRREGDKVVIDESPDGWHGTSPLVVSFWVPSWTLITHPNDTIVAFGAMPMSPRTTGALALLLRLGQMMRLSETNLISKNVIVTRTRPYLHSEMEKVRTLSFERDTFVPSPLRSVEISPVQVKLDESCQKIASLTIRGDLLVKIAKDKLSSGAEVTVVQSSPCTLQVQFGGLRQTMAFPFPVDVAQAKTKIARTSSYIEVSVPAYYPLTSGGFSHKKFPVSLVNGRPANWNIHYLNLDILPQLDLRSPPALFWITNHLSMMFSDRESIIRQKDEHAGEDWVVDIKESIEHLLGQYAGVYGTSRQMILGLKSPVGKVLVLIFPTDLRLDLGSHTLVMDACILPITPASELAVEVALRSMSHSGISAMATSTDEVTAWCDLLPAFVERCRNWEHRENCTFKRGGIPLTKDFHRSPLCSCAPGNPSVDFLGKREWRGLAPYVTRAAISPIQPVSYLEPVGYERIKALKGMYAEITQEEEAEKARRAKEEEEEKERLEKEMAGKCRVCLKTENLMRCGRCKKVEYCSGACQKADWKEHKVGCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUR5</accession>
    <name>A0A2T6ZUR5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_843757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUR5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015525065" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13636" checksum="DBC43746D48C1096" modified="2018-07-18" version="1">MLEYGTLLLVASLLSLSYHGGRVGSVAVATVRLLEKILFPCHSQPLSLFLLRSAQHPQNLVRSLTPHQINFSEKFSLLTSQPRKLPSPPLTTAHYFTAQHIFYHTFYRYLIPLTYSPPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUT0</accession>
    <name>A0A2T6ZUT0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_844700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUT0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="18479" checksum="52CF8E3DC53C5397" modified="2018-07-18" version="1">MQCCTSTFSIDGFFSCTTGSAIASPGSLGALVFGPGKRIPMIIAKFPDSLRSPLCTSTIPPSPSNSYNISFNQSGRFSVMNTNYNTSCGKSKLVILCVPEPLAGERRCKWNVESSAHKRFYRKNSRFHTKILHWRKFAKIQTIYDILPLKTVRTSFSIYKCLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUY5</accession>
    <name>A0A2T6ZUY5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1082124</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUY5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUY5"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF147">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="250"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU79302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="490" mass="54430" checksum="A15FA40B124830E2" modified="2018-07-18" version="1">MGSGWLEAKEVRGPSKHALNRWVSYTMPVIMAGLVGFATWVFVALVCVNHLLIGQGRKGTAIALLVIYFVLFLLMSSAYLRVVWVISVSPGFIAKQSTDSEDEKFPGSVESRSDAEIGLGGVQAEGLRKEEETIQLPEPMTIAGSPPENETESLPNPPPQPGSAKGVPRPALSPETTAQPTNGSSTLSFPASSNPPLQSPARQGVFPENALGSRPYYTHGPPRPQTSAGYRNLDEWFQRDAFVCENDGLPRWCVHCQLWKPDRSHHCSELQRCVWRMDHFCPWVGGVVAEPSYKFFYQMVFYGALYCLFLIVSIAVIFRQQINDNGNQDARWAACLALACVFGLFSGVMAGSTTQLVYRNVSTIDSLNYKTKVYQLALHDPNAAQTPPPGQQISAVMPARVWLPREPGPGQKQRCFAIVSTQPGDNPWRLASTLENFKEVLGYSFWDWWLPIKRSPLEAKKSGEGWYRWNEELLARLKHQAGITQPSKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV87</accession>
    <name>A0A2T6ZV87_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1064293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV87"/>
    <dbReference type="OrthoDB" id="5420021at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="275" mass="29108" checksum="642E0EBD1A032B0C" modified="2018-07-18" version="1">MPKPQNRRSTEPCMAYANPDSSTITRQPHHTTPSASILHHHHLPSSPFKREEEDPPKNCRYNKKTTMSVYGQNNDTELRERLSAYIERGGGDWDTAGDFGADPPGSPDSLFDYPGPSNIASAFAAAASSNRVRTRSLSIRPGPPGTLPETEVQVEANGDNDGWTDTDSAASRAGSVRPDVTFAAGTGRTGGNGGNGGTSRARRAAYGSGGRSVAREAPSVGLGMAGEGPMPAQSNVAVPYSCWSCGAMVSIRRKEPFVMCAACGGRIVMKVRPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVI5</accession>
    <name>A0A2T6ZVI5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1081616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVI5"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41702" checksum="9A3E0E828441EB8D" modified="2018-07-18" version="1">MGPKPARQRLPSSTTSDAPDAMPGPERKRKQSTTPGKSNLTGASPKDINAIFPNGFDQGTFHNYPEEDKIATNIHADLSISFCNITGPNPRGQLRFLEISQNIYRTTPNGVRIKFGDGSTQLQFPGRLYSSAISGLSTRIKISPQKCIGYNAHKQVTTALFRTPIRYPQDRQFNLDHYHSSPPNKQIHYGRKTLVVKCAATASLGSVYFGPDSQYNKSDIDLTEFNDDTLLCMELEVARHAVRLAREVAGNISQKLNTVTFTKIVVMTSSERVVRGMTEFLSHWRRMGWKGLDVLFFPKVEANKRGWEWLDTAIWRALENELEVDLWLVPEEAVADAFDLVKKPKVKFLEENFQKHEDTEEPGLMEGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVL9</accession>
    <name>A0A2T6ZVL9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1081527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVL9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVL9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="18993" checksum="1A4BC3FA616DA97C" modified="2018-07-18" version="1">MFLHEYNHIFVRPEEGNLEALRSHYPKHPHQNPPSTPSPISPCSPYPTPTDRRPSTTGSLLNPNNPDAAPLTPALRSPLPPLRPAPQEPPITPKPQFASYEPVYETVVTPTPTMQPVMGFPALQPMLSDGSGDNGPSGAKARKRESSMMFMMGRKGYNRGANNAGSSKLLFVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVQ9</accession>
    <name>A0A2T6ZVQ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1081631</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVQ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVQ9"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="152"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU79504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="244" mass="27430" checksum="4EE7EC88C56DB68A" modified="2018-07-18" version="1">MMSSTADTDPFIQFQNELANLLESARTSFSSYLRIRALHAPTAAPSPELLSAQAELITLLDEISTDLSDLHATVRQMEADPYKFGLDVPEVVRRRRFVDEVEGEVGDMREELNSTSSPSSRQNAGAIATATTDDRRDEESSGWNGYEMQYQQEIMHDQDEMLEGVSRTVVNLREQANVMNRELEEQTEMLGALDGDVDRVEHKLKKGVRDLNTFIRKNEDTASSCCIAILIVVLIFLLFLVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVR4</accession>
    <name>A0A2T6ZVR4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_812998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVR4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVR4"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="809" mass="86618" checksum="2746514DA4272F27" modified="2018-07-18" version="1">MGVCRDCFTPGTTYLDAPRTHHYGQRWHPKKGWRVKRKKTSRRVSFGWFARSRRSGSSASSSSSSSSSSSSSDSGSDLSDNAQKRKRLQKNIRREQRALRRQEKRESKYSIHSSHRRRGSNSSMLSNPGGVAKSMWRTVTGSTAGSVSGESDSRHRETGRHTSTRTRKHSSGVLRGGDLAKAKDSSLYYNPGYGSDGRAHPYHYTASASGTNGQKHHSDSSASLYTGLFGISDHKGKGKGKHSESYHHSRSSGEASHPGLIQFPSETSSGGEESGLHYGVLYSSSPSSYGSSKNTGMLSYFFGSKERSKRRKHARKSKKYSSSTTHSSSHHHGRDIVGGSSSLYDMRNGRKAGSSSSSSSSSSSSSSSSSSSSSDNESNYSGLIYGSHYKKSKRSTDSFSVRSGKSYAGSIAESFRSTGSRISSAFGIGKRRKSWIDYGTPQSGHHRQSSSKHSSGSAAIGISGRDSGGSRKWAKSSSSGHIAGGVMGVAGAWAGRGGRSTSRKHSSHSASHYGHSSSGSWAAGGARHGGFFSGDTRVSRSGSVSSRLSSSSGGSSWYEGKAGGKEKQRKPYIFQAESTKVTPVTIQSSENQTGLFGFGGSSDVKTHEGVLVSRTTTESRVYTDGERGRKEVFVGRDHSPKRPASIGATAAAREGRSPHRSEMVSGRHRTTSADSWESADSRHSKRKNRHHHHKTATTTKVTSSSGSGFLGIFGGSSSRRSERSRSRSRDSRMRKQVGGGGSKSEIFVTRDGKIVSENSKTGITTTILDVSESSKDVSKAARADSSSRNSTKRTVITKSYGASSNQGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVW8</accession>
    <name>A0A2T6ZVW8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_978458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVW8"/>
    <dbReference type="OrthoDB" id="4138121at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="7766" checksum="844153C99B8EFEE5" modified="2018-07-18" version="1" fragment="single">QAWLVARLLRSPSFHRMVARMHGRLTGKGQVEDYSELGGTKVQGKGKHGFKKFVDIYIDEFKNNFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW66</accession>
    <name>A0A2T6ZW66_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1080912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW66"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="764" mass="82746" checksum="43466883A7C50609" modified="2018-07-18" version="1">MTSSSSNPPNPPPVPLPPPSSLVPTISPATLSSLAIYNPSLGPTDETVHDQIVFYTSRRGNAITANDRLRQIGLAQGVVEFARGFSKTQNLSSVETEKSRIVTLEIEEPGWWILAQIDLTVIHNPSTYPPTIKYTSQEVSPPALLLADIRRAYDQFHFHYGSFATNFGRLGRSAFCKRLEKFWLRWAWGRWEVMLHASPATGMLGGGGIKMAGGRPGKEMGSKERDFLKGWADKEKSKGLVDLVASRFGEPPEENKKAKGSEGHNGFWFWNSSNKLPTPSTPSQKGQQGPAFIMPQDGCILPGTGVLDSRSIQDVATYLSELYQYGDESFSRSSASSRLKKKRNRPKAPTKGDSVGSSSQANTSTIRPARAELHTASSSSGPTASVAIDEPIKDGGAQGRAAETSSQMAQELSNKKQSPSNTNAKILNLLTFGWSGGSAPGKDTRARGADSATSSLAPSSRTPSPAPMKVVDPQAVEEADGPASKIKDENPNRARFVIGFMGDLDVEDLDESESGGRITSRTIWASRSITKNESDEQARGDTTLDEGLERSHSRTSTIKQVGLEELRIVIYANHPFILAFIFENSTRHLTSPSFYRTIHHQLAPLYEPMLKFAPLGELKLSLKVPGLLSPILKPPYDILYNPKTRTIHCTLPPIPEPALEPVNPGAGAGWTRADAFHVHALILEILSETAGDMSERERSVRSTKGWWVNWMRLDGGVEGIVVRRAGEKKVTDAAAGLVGASSTGAGAGGIDIRSYFEGLVHGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWB9</accession>
    <name>A0A2T6ZWB9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1080832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWB9"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="65"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="444" mass="48674" checksum="3B03504B020EA7E4" modified="2018-07-18" version="1">MSTLLTSRTFRFARQLQSMVQARRFTVLAIETSCDDTSVALLHSPPHSPSIATLLAHKILTCPNRIYGGIHPLASLQFHRRNLMPLLQSLEISQKPDLIAVTRGPGMLAALATGIDTAKGLSVAWGIPLIGVHHMQAHALTPRLVAALNGGEDGVEFPFMTLLVSGGHTILLESRGLTSHKILAETIDIALGDMVDKCARRLLPEEVMDSYPEAVSYGAALEKFCFPEKEPEYAYHPGKTPERKQEDEEKVKRWGEWKLCRPLTKNEKVRFSDAFSFCGLGSTLDRYFSMKDGGPESISVEERKALGREVMMVAFEHVASRIVTALEASQTPPSALVISGGVAANKFLKNILSNYLSHNGHNIRIAIPPQKYCTDNAAMVAWAGLEMYRSGYISAPTVTPVRKWSLDNDTYYGVSDIDCEAGDKNGPGGVLGISGWVKREVEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWJ5</accession>
    <name>A0A2T6ZWJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1080740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000080">
        <property type="protein sequence ID" value="PUU79855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWJ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="599" mass="68122" checksum="40F4C4CC2A9A0C62" modified="2018-07-18" version="1">MDDLGRNIAAPLGSLFTPEPSAGPSQILPQSWPLPSRELASRFAGWITIGEQRDFYDDRDCLDPCHHLASEKLQYRGEDDVVIFDYSLDPDYLSPARGNPPVEEGGPSSRRFGANDDIFFRVPKNKFIRSNQFDQIINPGRESPQIPSRGARLGIIDFPQCYDTYDDGLLKSMGARLGLLREGGTAFMSAHLQRAGALPGRGRFRTGISLLAPFKRPSEFSERNPSRDRIILFVSFPYFGGSSEEIGLDPESESVLLMDFRRLGIDVPHDRVGVRENERDNIGKILVHQARYMIFDNYTMATFRSKEDSAKDQVPLHRFQERIGAFRAMIHMIANRVSSELRTLERLQASLHELEEEIDERISDAEIYEDQEKQKRVRDLLTDINRLSAVTFAVISVVERQIAVLQDLHSVFATSYRTRTREYEKRHPLRGNPFHKNVAPIPILSENPEQIWPNALDTIDEVIRGRKSFINKVKDLVERMDIRRQILIGFLKCGIKVTAAGETKGRVARQPQSIVARQAGQSIMLFVFTVMTTFFLPLIFCTLYFGMNNIKKFHDNPLSPHDFWRITIPICSGIILVAVLIIIIPLGLGSSQRIYDAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX66</accession>
    <name>A0A2T6ZX66_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1173580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX66"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="347"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="589" mass="67250" checksum="7D510EA02338577D" modified="2018-07-18" version="1">MGLGKTLQTISFLAFLREKGMVGPFLVVAPVSTLSNWVEEIARFAPEIPAILYHGTPPEREVMRKTRMAKLDATFPVVCTSYELVMIDRKHLKKHNWKFIIIDEGHRIKNLNCKLISELKKYNSANRLLLTGTPLQNNLSELWSLLNFLLPDIFDDLDKEKKVGIVASLHAILKPFLLRRIKADVETNLPPKREYILYAPLTRTQKDLYGMILDRKAKEWLIEQLLSSRHNHKKRKLLTVGQESPNKRAKSPDPKRKKKCVSYKELSDDEYFQMLEEAPPEEEELEPVLTEEEQQVLQATQEIGAKKLQNPIMQLRLACNSPHLFYWPWGEGSPDERLVTVSGKMMLLERLVPALFARGHKVLIFSQFTRMLDIIEEWAMTLRHWPVCRIDGGIKQEDRREHIRRFNKDTGWNLFLLSTRAGGLGINLTAADTVILFDSDWNPQQDLQAQDRAHRIGQKKPVIIYRFATAATVEQTILEKADGKRRLEKLVIQKGKFRSVSAPSALEEEEIAQLLKEDFEKVNVVEQGTQLLTDAELETLMDRSPEAYSRAARGKEEASGAFKVVEIGVKKEEDTQGAKGGADDGADGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXA1</accession>
    <name>A0A2T6ZXA1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glucosidase II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1080073</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXA1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXA1"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000039">
        <property type="entry name" value="Glucosidase, alpha neutral C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000023">
        <property type="entry name" value="neutral alpha-glucosidase AB isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015750838" description="alpha-glucosidase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="15">
        <location>
            <begin position="92"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="14">
        <location>
            <begin position="377"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="16">
        <location>
            <begin position="715"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU80122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="950" mass="107878" checksum="5C8872669809FB8C" modified="2018-07-18" version="1">MRYQPVSARSAPVLFLSFLSLLQPAQTVKHENFKTCSQSGFCKRNRALADRAHAAGASWAAPYELDEKTLQLKDGVLTGKIWKTEAGGIELPLQVSLFENGIARVTIDEAQRRTGEIILRHDSKARKERYNEAEKWALVGGHKFQKTAAMETKEGVTTIAYGLDSYEARITHKPFSVQFLKRGEVYVVFNDRGLINVEHWRSKVEKAEGEGLTEDEETYWEETFGGNTDSKPRGPESVALDITFPGYDHVYGIPEHATSLSLKETRGGKGNYNEPYRLYNADVFEYETDSPMTLYGSIPFMQAQKKGSTVGVFWLSAAETWIDVIKTKQNPHALTTEKASTQTHWISESGLLDVFVLPGPDAASVYRQYGELTGFTTLPTMFSIAYHQCRWNYVSQDDVKDVDRKFDKFDIPYDVIWLDIEHTDGKKYFTWDPLTFNKPESMQKTLAKRDRKLVVIVDPHIKNDGNYAVNKEMVEKGFGVKDKGGDKVYEGWCWPGSSHWVDCFNPAAVNWWKSLFKFDKFVGSTPNLWIWNDMNEPSVFNGPETTMPKDNIHHGNWEHRDVHNINGMSFHNATYEGLRIRLGNGKERRPFVLTRSFFAGSQRSSAMWTGDNQADWPHLQQAFPMLLANGIAGFPFAGADVGGFFGNPSKELLSRWYQAGAFYPFFRGHAHIDAKRREPYLAGEPYVSIIRDAIRLRYSLLPAWYTVFHRASWEGMPILRPHFVMFPDDEAGFAIDDQFFLGDTGLLVKPVVKESATETTVYFPDDQVYYDYFDFTTYHRKGHHEVPAALEKIPLFMRGGHIIPRKDRPRRSSSLMKYDPYTLVISVSSEGAAAGDLYVDDGETYAHQSGAYIHRAFTLKDNTLHSTNLHPEPAKAAAYNKNMRSVRVERIVVVGVGKEWATKKEVEVKQGSKTWKAKVIYTEGKDGKANTAVVRDPKASITKDWSVSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXK5</accession>
    <name>A0A2T6ZXK5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1079783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXK5"/>
    <dbReference type="OrthoDB" id="5380457at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="22761" checksum="C7692C7562C617C5" modified="2018-07-18" version="1">MATRRRDHFTSIHFTHYPPLIVTHDRLDPSPFPILEVELDHYYTLTRKAFTPLLKHMTMPAHVTEILASFSPPDTGAPVHQHRTMTLLITKMTTLFPELIFPQISYLINVTRELTDEGVKRRNKWIRGKVTKDLGKTRKRLEGLRDVIVHRIVGSERAERHRELLMMDWVLGNLLELRVGKSIAALEERLVTERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXM1</accession>
    <name>A0A2T6ZXM1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1123859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXM1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXM1"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="26566" checksum="3C3C961EEB41C22B" modified="2018-07-18" version="1">MSARRRLEQRRLGAVNQALEKTTPQKPPLRAWRQITIGNNITRPQKREQWKPLMLSLDQVITPEQDTLIHSSQSGKQNWFWMSVEIKEIVSSSAGHAGQSQGVGLESVYLGYILLSIKSAVKSIVVSIESAMDRVVVMIFPCAMLNNMYTLSVSGSAARQHVNDAVIAAIQKLKAAMEALAAIHINARDPTGDWPVEQQINSTQASPGHSSYLPSTTLLISRTAGVHKAEGKVDLHDVPGIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYL7</accession>
    <name>A0A2T6ZYL7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1079014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYL7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="90" mass="10470" checksum="DEB2118FB651CDD1" modified="2018-07-18" version="1">MKPASLLFFAPTKRIFMSSRLAKHLLSVFFLLFFSFSSSGVYRTLFLHNSTSTGRRMISYLQLPLSYVAMNFLLEGRKRKKLNNDLSQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZF0</accession>
    <name>A0A2T6ZZF0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin cortical patch SUR7/pH-response regulator pali</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_973256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZF0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZF0"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="31371" checksum="DC38496E2E44369A" modified="2018-07-18" version="1">MRGLAIISIALSMAASILGLLVLFAGRKNGFLSDTYIIKVDTTNLTLNTSNTGNSVLDNILNSATPGTVNTTAERLGLRDFYKVFVMNFCEGDRDSNNKQISNCTKQKGMFTFNPVSTFNNQLLQGVKLQDLGVKTLELENDIKVLNVAYKTMFVTYCGGIAAAGVIMILGALGFFGGRLIECANMMFAVISFLFLGIASGIGTAAGFKICDAINHEMGKIGIRASHSKMYLGMTWAPVTCMLILTFLWCGACLSRGKDKTHHKDAGKRKSGGHKSDRAKRSWRKRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZN1</accession>
    <name>A0A2T6ZZN1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1099999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZN1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZN1"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001196">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_1G12380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="388" mass="43161" checksum="ACD5CAB781BD3910" modified="2018-07-18" version="1">MSMSNDPGHFFQTETALANAKRRATKSSNKNGSPITLASKLLSIIPDLTSPMRVYVAESGGIARRIDLESGDKSCIYKGHTAPVTSLALNAAQDVLFTGSWDKTINAYSTETRQKLRTFVGHSDFVKSLLFVPSPKHEDGLLFSGSSDASIIIWDAGTGQRLNTLKGHKRAVGALAVDPVTSNSEAAIIYSSGSERDIKRWEIPYANVGAATESRETIMEHDTSVNMIRFQGEDADMWTASADNTARRIDIRTEVKKNGTSWSDVVLKHPDYVNDVVVEPRGRWVITACRDEEVRVWNISTGELYHIYDGHIEEVTGLAIVGKGEVVVSISIDKTVRKWSLRPVDLTKTVEEKKIQEQEIKEEPIEEKKECFLTEEEERELAELMDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZS6</accession>
    <name>A0A2T6ZZS6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_894949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZS6"/>
    <dbReference type="OrthoDB" id="5329385at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031342">
        <property type="entry name" value="Mug163-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17119">
        <property type="entry name" value="MMU163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="23437" checksum="D1153CFC8A47070E" modified="2018-07-18" version="1" fragment="single">MLRHSLRQSSPLRRRPLLALSTNTNTGTSTSNNSTPLTSSLAPAPTSTPRKSPTHHHHHHHHQPSYFAASIPTPSPPPSQSSSKDHTPPSERSINLGRTIQTLRSHLPTLLQTPLPLDILSPSITLNLFPSTHPHLPTVRGRVAYVAALWTAPVAWGRLPGRNRRLEILSERMLRDGQGQGGGEGEGGEEVFVVRWRTGEEEDGFCGVFLFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A000</accession>
    <name>A0A2T7A000_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PXA domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1078034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A000"/>
    <dbReference type="STRING" id="42251.A0A2T7A000"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015731507" evidence="4">
        <location>
            <begin position="22"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="7">
        <location>
            <begin position="99"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="435"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="894"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1259" mass="140106" checksum="5A1002208F1871F2" modified="2018-07-18" version="1">MHRRSLALTTVILLLLLNTAAQYFPSLRLIVWAFFTGSAASLILFLALGLFTVHRRPSDNNVLKTIKPLAFASPALWSKEVEAIALEDSFHRLPLYPPSFVLSDSIDAILSNVLRDFVNSWYSKISSDPSFTIQVDRTIRHALEVLRDRIQTLDLVEVIIGKIVPLLTAHLHDFSAAERAVRGKHLNKDLTESEELDLAIAGKYREGKLHPAASLKSSDTKLAQQDHLRLLVDKILPVLLPERERKSRAVVAIVKEIVACGILFPVMGILSDPDTWNQFIEAIGRSTLQDRKTVRKLRAALDQHATPRHPNSPGHLRNYSQVELAPSQPFIRLSAKDDERTFERFIRSIRLCNNLSDARRLRNEVSAQLKRDERVEPKEGWSVYLRRLEVGKREVDKRVAQLSTGVAGPGGGPVRTHSEIFAPKQATTSHLEFATLQQVLRDSSGLSYFMEHMDRRRRLPLVQFWLVVDGLRNPLEEDVSSSDDEQETSTSTTHAAWTPSDRADLAQIHEAYLSMAELQIREKTKLAVKEFLKAGSNATQEQYIRARAAVLRAQTVVLEEMQQKDFSEFRASDLFYKYLASDETAAAQVRPMSGRTSSEMVRSSSWANAAHPSEASDPMVSSRHSLDGARPVERSLEDWDFGPLSNSRQSLDEEPPQYSQYLSQPQQEPRRHSPENGIVEAMEAALNDIIEDRPSLDESRSSPFQNSPVLTGPNSPRSSIDVSRDNGNGTGSGSGNGNGQKLTVASAVKDKAKPKPPSISSLGLVGTNSSGGVFADDELFPDEAAVVGCHSSGEEAEDKDDIAGGSGSDDEIRQAAPGDLGLAEAIAALTFDIEKLSTQEAVVDSLYRKAELTNNTVELRILRKSKASLHREIRRKELQRQQYIVQESDNSLYGRATIRIKSIRVGKENGQEYALYVIEVHRPAGDQMPPATWTVPRRYSEFLNLHQTLRSSFPSVKPLGFPRRRVVMKFQKDFLEKRRVSLETYLHSLLLLPDVCRSRTFRSFLSQSHIAPTPSASSDPAILTPADYRRDIMSRLYNSIADGVEDVLGTIPLLDQLSQQNPPPSIPFPQIQHQYNPPSIIPGETIDAAEAEAELSAFENRESTPFVKPICDIFLEVFQLNRGSNWLRGRAVVVVLQQLLGGTIERKVREQVRGLADEEGVIRYLDMLKAALWPEETVAAGQQQQAVRSAKEKARARNEAKIILATLVPDLAGSVVGRENARAAGRRLFAGLNNGRLKCVPPFFSFDKVGWADVCAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A084</accession>
    <name>A0A2T7A084_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1020301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A084"/>
    <dbReference type="STRING" id="42251.A0A2T7A084"/>
    <dbReference type="OrthoDB" id="5274906at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015614085" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="18964" checksum="8CA6F1A56AB9B349" modified="2018-07-18" version="1">MKFTLITTVSILSTLASGLALPDLTPRGAVIRPDIAIVIKEDFPTTSFPTTTAEVSRSNGQHNVKTLLAFTVPACTGKCTVSFSDATTATGSRRMQFFTTGSPPTDGNTWTSKPYTNIHKGTFTTSSSGAGAATVVEDFGLTFDCPSTSTKYGFEVQPVWDNDSVTWDIKKAGFIITC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Q3</accession>
    <name>A0A2T7A0Q3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP synthase subunit H-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1077556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the V-ATPase e1/e2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Q3"/>
    <dbReference type="STRING" id="42251.A0A2T7A0Q3"/>
    <dbReference type="OrthoDB" id="1508846at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008389">
        <property type="entry name" value="ATPase_V0-cplx_e1/e2_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12263">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05493">
        <property type="entry name" value="ATP_synt_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="79" mass="8933" checksum="807377BBB7F60B16" modified="2018-07-18" version="1">MANGWSVFISLFAIVGLSAVVWVFAPKGENQTVWRSSLILTFAACYILWAITFMAQLHPLITPRRSNLRPEAHSDPRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A152</accession>
    <name>A0A2T7A152_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A152"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="106" mass="12500" checksum="209AFA23531E789C" modified="2018-07-18" version="1">MMSHSLALQPKKKVILRNALPFFLFFFTIFFFPSSTGARQADWRDREEKKLRPSPRGCSWLRGATSTIVLLTWAVCAKEWKFFGLRCWGFGWLDLEGGFLFYINFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1H1</accession>
    <name>A0A2T7A1H1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_595315</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1H1"/>
    <dbReference type="STRING" id="42251.A0A2T7A1H1"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="165"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU81589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="405" mass="45412" checksum="21D989DAFA371318" modified="2018-07-18" version="1">MGIKGDCSKQTLHLWSLANMVYQGLFHLLRDNAPDAIKEGEIKQHFGRKIAIDASMSIYSFLIAVRSEGQQLTSETGETTSHLMGLFYRTLRMVDNGIKPLYVFDGRPPTLKSGELAKRSARKAEASAAHEEAKEVGTAEEVEKFSRRTVRVTKEINDECKRLLTCMGIPYVEAPCEAEAQCAALAKAGKVYAAASDDMDTLCFETPILLKKLMLSEMKKEPVQEIYLDRAMNGLGFTRDQFIDLCILLGCDYCDTIPKVGPTTALKLIRDHKSIEKVLEHLGPKYAVPENWPYQDARELFKNPLVTDPEECEFKWEAPDMDKLVAFLVGEKGFNEDRVRAAAGKLTKNLKGNTQARVVDFFKPLPKTAEELAGMKRKNEEKVAERKKKAKAEKAEKGKAKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1L4</accession>
    <name>A0A2T7A1L4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1099586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1L4"/>
    <dbReference type="OrthoDB" id="5386564at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754501" evidence="2">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="221" mass="24234" checksum="65765BF1458CF7D2" modified="2018-07-18" version="1">MWLSVLPLTLLIWTINGIAQLFVKPEVGSPMARFNPAWALVPYLVLFAVVAVYHRGEGLKGGEKGSEGTEGGVEEEEISEDFLDYFLDKLYTVAARLRGHFTPRRARRFTISLLFATSLIASYFALQYLSPHIAALAKALSSPPTSGPWEDMDFMYFVPSTSTGEQSTSSGMENAYGEYHPGTNALEEELQEGLGWKGVLRLAAVLVMGPAGAVAVRRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2D5</accession>
    <name>A0A2T7A2D5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_970129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A2D5"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1171"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1354" mass="146250" checksum="3EC9A94A9543CB4E" modified="2018-07-18" version="1">MANASTPFALQSLLEKMSSPDSDYRFMSLNDLLSILTSPNASLTQADSNLTSRVIDGVVKALDDANGEVQNLAVKCLGPLVLKVRDNQIAPLIDRLTTLSMTSTDPSIPSTALRTIISSLPRPVAVSSAVPGSPVLVQKPDAIHQTIAAAVQAIQKTLYPKLLILLKPGTETVKGGGASLDSIDLLIETLKCFGPVLGGKEVEQLQVAVMELLESDRTSQVVKKRAVTSLSLLCVYSPDELLSSFINHLIESFRAQGKHVNPTRLRLLVSVTGALARDIPDRFGPYLKTLCPFILSVVDGKDIQDRELGDEPEMEMDEVREAALVSLESFMSFCTSNMTRFTEDVLSAGMIYLKYDPNYADPADEEDDEEMGGTQQDDGDEDEDFGGSDGFGGSDDEGAFEEDGNFSDEDDISWKVRRCAAKLLSTVLSTRAADLILGEQEGGGKAYKQVAPLLVERFHEREENVRLEVLATATVLVRKTGEVAQGTFTPLSPSRDRRGSTDIVMGPPPKRRRGSDASMLDTTTYDVPGQSTDENGVKNSLQALMPRLSKSLSKLLKTKSTTLPTKQASVTLLSAIVSVLEGGLDGVLGLFIEPLVDATRGGSAVSGSNVVAATAAGGSAATATGSSLRIEVLRLVGKICENHSVQVVGEHFDTLIPAMIIAVEEPAYKISSEALNTVVSIVRLLTTEGSTGYGEYLKGLYDVIVAKVGNGDADLEVRERAIVALGVLLSKTSGQPDLIEPDRRTAALGMLVERAKNETTRITAVRAIEVIARNAKTTGDVNPNWVKTVVVECGVQLRKANRTLRGASLDALRSISANENCRKAMDPQSKRDLVDVLTTLLPAGDMHLLAPTLTIIRWMMIDGDGVYVTSGINDGICGLVRSNLGSGLVVESLLGLVKAIGENDTVGKKTVMNGLLQEVGVNGETSIVAKVVAQLLVSGGGKQGGFTIGVEEFVGEVVKTTDDKRKCLALMVLGEIGLRMGPSFSVGPETFLEQFHAKSDDVPIAAAVALGLASAGNVQGYLPVIMQRLGGGDKDQYLLLHSLKEIIQHSDDTTANIKPYADQIWKALFSMAKNDDSKAVGAECVGRLTIIDPYSYLPELQKHLQSESSAIRGMVISALRYTFTDTEASYDDLLRPIVVDFLTVMVDDKELENRRLALTALNSAAHNKPHLIGQHLQSLLPLVYRETVIRPELVREVQMGPFKHKVDDGLEVRKSAYETLYALLETSFSGIDIQTYFDRVIAGLQDEHDIRVLCNLMLTKLILLAKGETLRRLDSIAECFKATLNQKPKENAVKQELEKHAESIRSTMRATVALNRTAIGAGVSGKTGWNGYWEWAKTGFLNELQILEGEERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2K3</accession>
    <name>A0A2T7A2K3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1075892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2K3"/>
    <dbReference type="STRING" id="42251.A0A2T7A2K3"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF1">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="255"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="621" mass="71678" checksum="DD61635370F02B32" modified="2018-07-18" version="1">MVNLRSLLSADSGAGRDTSDDLREHLLPTHRGEHLHTTVPAERVTKVALRLKFLIEAAVPCEVKESHITRPHSQIITKQVVLLAQEAAGHEDRACVVYCLLVCLRWFKRQARLEMYDEGLYLLRASACQVIAKLTIEDISDHEYLFQEVLLKRYSILKNGQKTTPANAVERAVDLHATRVIGSSGYQKCIKYLWRGWVAQDLNDPTQFCTYRKIADKGFWSHFDHDRLRTPKYQNAFQVLVSIIYLILYTVAINTVNPTGDIDVEEACLYLLTVAFMADEMTKFWKVGRFYLTFWNVFNLTLYLALAVSFVLRMVAFSKAAGGEERKYWDLMSYNWLAFVAPMFWTRMLLFLDTIKFFGAMLVVLKVMMMESLIFFALLVVIIIGFLQGFIGLDNADNTKDSSFFILESMAKVILQSPEFEGFDNFAHPYGIILYYLFTFVVMVILLNILIALYNSAYTDITENAVDEYLALFASKTLQFVRAPDENVFLPPFNLIEIFFLSIPFEWWMERRKYQKLNDYVMTVLYSPFMLLIAFIESREAHHVSRNRARGEQDDDAIEEWEEMQGDDILGEGWSEKVEKTVPNIEENPAIVEIKDLRSHLDEVTSSLRRRNVGDSSDDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2W1</accession>
    <name>A0A2T7A2W1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1075750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2W1"/>
    <dbReference type="STRING" id="42251.A0A2T7A2W1"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="4">
        <location>
            <begin position="95"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="322"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="592" mass="65780" checksum="EE2FDF63173DC6EE" modified="2018-07-18" version="1">MPLRLPRVLPQSHRIWTVQLNTWTPFLYPFLSPGVAARPLTPAQSLLWCRTLSTTIEQPESRNDINLVQSQSAEEAVELVSVQQPQHPHAEYSTVPFVDMQELTLIAGSGGNGCVSFLREKFIPYGPANGGNGGSGGSIYVQAVYGETSLHKLSREGTVRAKPGRNGKGSSINGKRGDDVIIRVPVGTVVREISRWDPVGEELEGLQDENVDDESKQHNHHDRWVHYPRSAAENVMSENFMATKYPKTHHLGASTMLGITHPRKVYLDLSKPTMEPVLLVPGAPGGLGNPNFVTDGRRRPKFATKGGKGIRMKLQLELKILADIGLVGLPNAGKSSFLRAISRRKARVGEWAFTTLAPNIGTIVVDERHLPPPKPGEMQKRLPRFTIADIPGLIADAHLNKGLGHGFLRHIERAKALCFVIDLSREDPVEDLKGLWREIKAYEQGFSGDEGGSSVRGMMSEMSGEKHSDDRFIEPMAETHEPKRRRTPTTTHIRFNEEDGTFEYFEPESGFVFSQKPREEAPRMTSKRWFVIANKADLPDTEGKFVALQRHLEAEKEKRGDGEDIGLIPISALKQEGVESAIDWMKSILGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A307</accession>
    <name>A0A2T7A307_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1106041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A307"/>
    <dbReference type="STRING" id="42251.A0A2T7A307"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="23885" checksum="0F5B5F439E528BDD" modified="2018-07-18" version="1">MVHNSAETKDSSITARGELCVGNRPGSWIDRLRALEDDVAKLGEEVALNGARLTELDDQVLALVLLSKEERQARNQFIDTFKRDKLDTSNNDSDGEIIQEGYMAAEEGPNAIADAALYVLGERSDVYIFEELYGLEPLQVLRINYEPAITALNIHAGVISSQDKVGSEKFYESFAEFIKLLKAPECGESFWIPSSLTDACESFLLCAKDEVSDRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A309</accession>
    <name>A0A2T7A309_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1075841</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A309"/>
    <dbReference type="STRING" id="42251.A0A2T7A309"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU82109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="24925" checksum="E70E41A496F51907" modified="2018-07-18" version="1">MESKPTGNLSIDGIHVDMEHLKKGEVNLGTSIMAALFDGGVILGADSRTTTGAYIANRITDKLTQVHDTIWCCRSGSAADTQAIADIVHYYLQLYNVQNHEPPTTEVAASIFQELCYSNKDQLSAGLIIAGYDARHKGEVYSIPLGGSLHKQRYAIGGSGSTYIYGYCDANWKENMTEGECIEFVKGALAEAVKWDGSSGGVIRMVVLTERGAERKIFFPDEDYKGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A370</accession>
    <name>A0A2T7A370_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1121096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A370"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="12384" checksum="DC04E211CAAC511E" modified="2018-07-18" version="1">MLGFRTLRPIAVRAIRPTLAQPWAYHLVTFIPRKRSHEFSEAGADHHSPDPESSGTTKKLAKIMGPMHNHVIVKGFEDLKEEIQELRRERRWLYGAYLGAVLVMFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A396</accession>
    <name>A0A2T7A396_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1062029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A396"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="21141" checksum="C94BA45A414D2A64" modified="2018-07-18" version="1">MVLSAHGLISYEGANSIRPCPPQGIWGFCGNYAGSVKEPAYSFHPRDPDRKPKRFRSIVLESSWTSTEPEPVDVSRLWHEGSEGRVRVVILVKLDKPNAQNQSGATLKISHCTPGAGATATATQIVYLFYFTEVFPAPGSVPEDPTITMEELFRGLCPPGYNPATVLTLRVDQLRREIEMFSIRPISANLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3I4</accession>
    <name>A0A2T7A3I4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3I4"/>
    <dbReference type="OrthoDB" id="5389029at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015551968" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15623" checksum="BD1E10131D76B0CC" modified="2018-07-18" version="1">MKFLLPIFLILPSISALPQQAPLRSSGKSSNNSYCSTTPESPYYYQARGAATIMHNVLGDKPCVQSSLSQCKSLLKWGSADIGICGERGYEIPCTEVGGYVERIMEDCKEWAENRFVTEGLWATNGKPGDEDFRGVFLYHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A446</accession>
    <name>A0A2T7A446_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_382672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A446"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015450574" evidence="1">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="12051" checksum="8C7D1ADDE64FCE5F" modified="2018-07-18" version="1">MAHTSLRFLLLVFSGASGIKPKPSRINQTFLPPLSLFPHPFASVLHDQVSVQQPCILPPFFWMEANAADLEVSRSDVFFRDIILFQVHTYYRLQIQNSHPSVRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4M8</accession>
    <name>A0A2T7A4M8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4M8"/>
    <dbReference type="STRING" id="42251.A0A2T7A4M8"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="65" mass="7256" checksum="CAB290F9A6D7108E" modified="2018-07-18" version="1">MTRIQINCVMEDFEKSPELSFIGIPMRDGVSAACKAYIMEPQFNPAVESQEIDLIHSLGQTRPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4P8</accession>
    <name>A0A2T7A4P8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TFIIE alpha subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1074340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4P8"/>
    <dbReference type="STRING" id="42251.A0A2T7A4P8"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="36703" checksum="5EC9A00C715EB601" modified="2018-07-18" version="1">MEIAKSLVKCVARAFYDTKHILVIDALMIHNAVRDDELGKLLGFQSKDLQKLCGRLKEDRMLTVHNRPEQKEGQQRPTNRTYYYVEFRSTIDAVKYRMHGVVKDVEKKMNKDADTKGYVCPYCQKRFSILDAMSLARDEMGLFVCDRCNTTLVDDDDSAEVKTSQERLGRLMEQMKKIIDMLKMIDDIVVPVNDFETAIANSVPVPRDKNHLYSIPVAGKGATSIRNSGAPASIEVSFTSTSEKTAAELASEQAMKQAQAEKNALPVWHTKSTVDPGATTTAGAKEAAEREARALDGIGIAQKSKEEEDKKAAAGDGANGIQADGKVIRCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4T2</accession>
    <name>A0A2T7A4T2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1074387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4T2"/>
    <dbReference type="OrthoDB" id="5399295at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="31461" checksum="DDCF7882499C8DBF" modified="2018-07-18" version="1">MEPFVVNSSQRFRQQLARSCSGKGVRSGGGLSSSCIYYSRGRHSSCWGSHNLLVHYHHSFTFLFDKNSLKMQVLFTHKSVQDSGVIGENVLGIKISNDLSTSLTLSIQPFTVNCDIKIPASTPPAPSALSSPVLPSSLPAPGTEVKVEEPESAALPPVASAIATQTSLPTPIVTSTPPPVSLLDTYKVYQLDRIFTADRFYKYLLSAPSTSAYITTDDEFLSALHGITGADDCNADLVVEAYDGMNELRRGMMAEVIKVVEEGLERDGNERLDEWIKIEVPKILDEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A543</accession>
    <name>A0A2T7A543_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1061551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A543"/>
    <dbReference type="STRING" id="42251.A0A2T7A543"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="224" mass="25183" checksum="8D7491ED069B0F74" modified="2018-07-18" version="1">MAQEILQTIAKALETHEPQFLVFSELDRDVASQVLAHLEQPKYNFYKSGFRLHYSAPDRYLRLVLSTEIHGSAASWMRSEVATWFGDGRLDVATLYKILGWKTTYENFSGEYATSKKTPDLAWTPCINSLHNDYPSVVLESGPSESNTQLMRDSLVWLQGTDGAVKSVFPILEDNRPDPYITIDEFFSGSPPAGLDPEEQLPLGLRRLRGLFKGTIQQSGHLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5E9</accession>
    <name>A0A2T7A5E9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED20</name>
        <name evidence="6" type="ORF">B9Z19DRAFT_282640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5E9"/>
    <dbReference type="STRING" id="42251.A0A2T7A5E9"/>
    <dbReference type="OrthoDB" id="1854899at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013921">
        <property type="entry name" value="Mediator_Med20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12465">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08612">
        <property type="entry name" value="Med20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="25370" checksum="F3EAB5A3D1071D2F" modified="2018-07-18" version="1">MPVAGIYWINTPLTTPPQNMVPLLADHLGKRHQPLYIGKWSLEHRLLRETVPSSSGTTTTTTTPPPSNNNPTSQSPQPHQQIPAGGNYMQYLELTHHPGKLIVSTPSAIVTLDREFELLVRSKLSALWSHRQTLRGEGLAYEVDDFKVRIANILQGEVWKGVLVEVEYAPCSVLAAAEGVIRGFVEGLGWPTGRFTFSGKGGGKRVEGEEWSVLDTGRQYCEVLRMGWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5N0</accession>
    <name>A0A2T7A5N0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1149644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5N0"/>
    <dbReference type="OrthoDB" id="5353310at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="10546" checksum="980BF37D04CFE7C4" modified="2018-07-18" version="1">MTYPDPTFYQRFYHAARNAGPPPDPEKLKKQNSGDEEGTWLAREKQKCKRSYLPCGAVFLTVLIMGIGIGALVQLLGIGGARGGEMVRIIHGWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Q2</accession>
    <name>A0A2T7A6Q2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Q2"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="278" mass="29734" checksum="36C43B45E59DE773" modified="2018-07-18" version="1">MTTRTTTPLSYTSSTTYHSTTPEPQGLGPPPPIRRQRSPSTNSHNSWWSAEEESPAPLAGWGVSIATTAIGSNSSSLRKQETSVTMGVGTPGRKRGQFSYSGAITAPSSSSSSSSGATMRPHYQLHYNPHHHHRPHHHHHHHHPTSSASPTSTATPSFSSSSSSSTSSHTSAHPISPTLPYNTPIDWKGNAARRAEYAALDRRRQGVAGLLRRAAAAACCFGHAGGEFWEEKCGDGGSVRRYRLALPAEEEGEESSPEGVVGEEGGEKGGARVRVWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Y0</accession>
    <name>A0A2T7A7Y0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1060744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Y0"/>
    <dbReference type="STRING" id="42251.A0A2T7A7Y0"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="509" mass="56496" checksum="91E632502A078E97" modified="2018-07-18" version="1">MTTPHRGLPPPPAMALPSPTQTPSGIGQLPHQWHGSEDIFKTWLMAKMEEERRKAEEEKTKQEKIREETRRIELEMLRESSRHMGHFIQQQQQMVQQQPQHHQQQIHQMPPAQQCTPGPALRRETRVIGQQSGGPAPHPQQMGPPPQAGMVPPQAAQAPPPLPPSQGYSPAYSLPPGSQRSGPQQPPAHPPPPPMQQPGPLARLPKLDTNDQRQAPPMHTGMPPTQIGGHPTGPPIQHPQPSQQPPTQSETSVNQSPSIFFHHWQPPHSTSVGTSTPVQATGSPQGQLGSPFSRQPQPNQITGAEYTNSPKKRKTSTQQGSAPQPFSPSFHVTPLPASTPRTRRGNSRQRSETVGSGARGYEPYAKVPPPRVHRRSIGEGSVHEGGPPSGGNGGSGPHHPHDQHQHEQHQQHHQQQHQQQHQQQHQQQHQQQHQQQHQQQHQQQHQHQHHQQHQRPPSVPPPPPPQHRPFSPKSEGRRETYQPPATSQPPSEGGEADSRSKSRNSNGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8R6</accession>
    <name>A0A2T7A8R6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1060401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8R6"/>
    <dbReference type="STRING" id="42251.A0A2T7A8R6"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="200"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="842" mass="91276" checksum="5A3B1B73932BC6AA" modified="2018-07-18" version="1">MTASDNGGIGNSGGNSNNGGSGSSNGSGGVSSLQSSMGGLGLSPGTSPISPTSPPSAPLFNHSSQSIFNNPGIGSPASSLLAVPYSNAGVRLHSFPSRSLSYSGGSGSALAIASPNVKAVVVAGSSSGSNSRGTGSDPAVKEVDDPTTPLSHLDKVAVPNTFSRLSATPATQTTFGQSGSDSVKLEEFLYTRGFLEGACSDVTIIAFGTRYCLHRLILDRSPFFSSCFNGGPWLESTSSEISLSPSDPNITQHAFELALGRLYGHVDRLKEDSHALPLLAAASYLDLQDLAESCVSSLLRNLKTSNISTVVRFVTNSYYGPLTDRLMESAKAMLYRDGWEMSFEEWEGIGGEVAAEIIGYDGFYVPSEWLRYCFVKEMIDWRICHSSPYNRATNEGCSLDDEDYDADGASAFDDEETDVKPLRELLENGIYYIHMSFEELQKIEMDRDVLGRSTVTQDTIREAFWNQTRLRQKVMNVPLNSPDLGITETETVRQPTPLGRKSSQRLPTPRFGEKLGESGSGRVTPTRQDDGDDGPDTPTTIRGRQTKPKYYIPTEDTTTVIGDCQDTPQHLVVSHPVHRASTSRASEGQTGAERTGGDEDRDSSIPFEELRYSEFPPFRFSAEFKSVRSLKEKKRVYSKTVFYAGSHWNIYIQKVRSKNVQLGVYLHRAKDRETAGGSHGSSSASRESETVGQVITVDERIGTIELHTRNTNHSTEDLGDMTVTTDGDVTTSTFTDGNVSGRPGANTSATRSAMPQPSSSEVGVPAVPYYVDSRPMIQTYFKIFSPSRKGKVLSMFSSGPDSFNFSQSWGWKSSSLILEEGMIGGDVDKDARLRFMVVLGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A978</accession>
    <name>A0A2T7A978_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A978"/>
    <dbReference type="OrthoDB" id="5294439at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="62" mass="7058" checksum="2C2B50AD6E4E2E01" modified="2018-07-18" version="1">MAVRANERTSGTIGRSSVGSNETKTIASIHRSIHTSTLNCTFPYVFTIHHSIQLYVYRYRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9J6</accession>
    <name>A0A2T6Z9J6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">enoyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="11">1.3.1.104</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1012458</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2,3-saturated acyl-[ACP] + NADP(+) = a (2E)-enoyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.104"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.104" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000698">
        <property type="protein sequence ID" value="PUU72170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9J6"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9J6"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141148">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000112">
        <property type="entry name" value="Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="41"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU72170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="42554" checksum="1AE73E3CD0DAA436" modified="2018-07-18" version="1">MFSLRTPLRHTFLRSASTIPKRHITVFGYTQAKALIFSEHGQPKDVLRLHSHSISPAYGDEIVVRFLAAPINPADINQIEGVYPSKPTFTTTLGTPTPHAVPGNEGAVQVLSIGSSVTDFTPGDMAIMRHTAFGTWRSHATARSSNLLKLPKSPSITPLQAATVSVNPCTAYRMLKDFVPLQPGQWFVQNAANSGVGRAALQFGRIWGLKSVNVVRHREGIEELKRELMELGGGGEAGTVVLTDQELADPEVRKGVIDRMGGKGAMLGLNSVGGKAGIDLCKLLDTGGHLVTYGAMSKKPLTLGAGLLIFRDLHFHGFWVSRWSDQHPVEKEAMLEEIFRYIASGELKDVPMETTVWKRDTKEEELKAAIERSTQGFGGKKQVFVFEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAM6</accession>
    <name>A0A2T6ZAM6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000508">
        <property type="protein sequence ID" value="PUU72550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAM6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="132" mass="14144" checksum="C51D946BE4D8C367" modified="2018-07-18" version="1">MSSAKVLGYLRKHPRLLVIVGGGLGLVYNQRTSSRAMTHDLGVIIDSAYEKLGESLALQIHTMGTGLKVESAGTQPTGPASSHPMIQAASREHSAMQSWAAKIKRCTTLGGGDCPRLMRIAASYRARIGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAU5</accession>
    <name>A0A2T6ZAU5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1097007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000504">
        <property type="protein sequence ID" value="PUU72566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAU5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAU5"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="273" mass="29555" checksum="C9D540A8F0BCED08" modified="2018-07-18" version="1">MSTDQQSSLLSEQDTGMLPRAQLLAGNLQAVLQRINSVAHSPNSVRLVAVSKLKPATDVLAVHERTGHTHFGENYSQELLEKAASLPTTINWHFIGALQTNKCKHLAEKIPNLWAVESVDAIKKANALEKGRAALLSTSPSTPKLRVYVQVNTSGEESKSGCQPTAAPALARHILEECKHLTLQGLMTIGSIARSQESVIPNEDFLTLKRVRDEVAKEVGVQSEELELSMGMSEDFEQAVGLGASNVRVGTTIFGERPPKKNDARDGASEQMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAZ9</accession>
    <name>A0A2T6ZAZ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1137098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000492">
        <property type="protein sequence ID" value="PUU72649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAZ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAZ9"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008251">
        <property type="entry name" value="Chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01393">
        <property type="entry name" value="Chromo_shadow"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00300">
        <property type="entry name" value="ChSh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="108"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="225" mass="24829" checksum="DF297589FD4DF729" modified="2018-07-18" version="1">MPPQIVTSDSDSDGDIIAAKATTNDVDVASVASDNEEAAAEAAEDEEEYIVEGIKSHRYEGEQLFLLVKWKGYERKSDMTWEPEENCEGAKEILQQYYTSIGGRPTFESSPALKGKRSRTSLGSTPAASKAVKRAKTSTPAATNKNGNESPPADGDAWNPPKGSWEGEITCIDTIEKTEKGLVCYVQWNNGRKSQHEIGTVYRKCPQIMLRFYEQHLVFKESGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB70</accession>
    <name>A0A2T6ZB70_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_894038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000477">
        <property type="protein sequence ID" value="PUU72723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB70"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB70"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="184" mass="19586" checksum="4B6D194F137EB209" modified="2018-07-18" version="1" fragment="single">MLMRLFNDESGVKDSTNKNSHLARDAALANTPIDHKSLMAHALAIARKSIYIPSAFCVGAIITTSSGAILSTGYSREQPGNTHAEQVAISKLLSSSSPVPGEAVIYTTMEPCNIRLSGNKSCVDRILECGWVKKVYVGVMEPADFVENGGKARLEAAGIGYQLVEGLEEECLGVARGEGGEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBE4</accession>
    <name>A0A2T6ZBE4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1069488</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000462">
        <property type="protein sequence ID" value="PUU72811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBE4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBE4"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU72811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="227" mass="24680" checksum="772D913A69111A3C" modified="2018-07-18" version="1">MSSSSSSAPLLYACVAHGTTILSEYAPSGTASTNASSLASLILPKITHASPQKLTYTHGQHNIHYIATASSQSIPSGLTFLVISTALIGRKLPFGYLLEIQRLFTSKYPASTIADAPPYGCAEFNSTLAATMRQFEAGGENEDVVAKAQREIESARGIMTENIERVLERGERIDLLVDKTAGLQSGAMEFRVRSRGLRRRMWWKNTKVCPYHVLLEASDGRQSANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBI1</accession>
    <name>A0A2T6ZBI1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_612550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000453">
        <property type="protein sequence ID" value="PUU72852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBI1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="123" mass="14008" checksum="6DBE83450476AEC0" modified="2018-07-18" version="1">MCESKKDCNLLIPRDPKYRYPTAPIFLPPPFLLVPQGLLFSHLPLHAYSHHRVWILTESSPLSLSLIVVFWVNFSPIHSFTFPHRTHLIVVPIATASLGQSLLTYSHSHLVRLSNHHEIICVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBS5</accession>
    <name>A0A2T6ZBS5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1096226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000439">
        <property type="protein sequence ID" value="PUU72948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBS5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBS5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="71"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="541" mass="58219" checksum="2EB57001305E4E7E" modified="2018-07-18" version="1">MPLPRPLAILTPHSKHISSSLLTPRFLGESSFHRRFSTSRIIMALPLFKELVAPNGQKINQPLGLFINNEFVKSKSGDTLTTLNPTDESEITAVYAANSADVDDAVAAARAAFHSPSWSEINPSERGQLLYNLADLVEKNTHLLATLDTWDMGKPLSVAKEEDLSESVAVLKYYAGFSDKIHGRTIDVGPRKLIYTLHQPIGVCGQIIPWNYPLVMATWKLGPALATGNTVVLKSAEQTPLSVLYLGKLIKEAGFPPGVVNILSGYGKTAGAAIAAHEGIDKVAFTGSTATAKSIMKAASVNLKNITLETGGKSPLIVFDDADLEQAVKWGHSGIMSNMGQVCTATSRILVQDTIYDKFIQEIKAQTEKVSVLGDPFSEATFQGPQVTRQHYERVLSYIEAGKAEGATLVCGGTKHGDKGHFITPTIFSDVKDHYKINQEEVFGPFLAIGKFSTEDEAIKSANCTSYGLGASVFTNDITKAHRVAAKIEAGMVWINSSQDSHYAAPFGGVKQSGIGSELGEYALTAYTIAKAVHVNLGTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBX9</accession>
    <name>A0A2T6ZBX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_937025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000429">
        <property type="protein sequence ID" value="PUU73000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBX9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBX9"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="64"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="192"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU73000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="353" mass="39133" checksum="CC0F05283304AC19" modified="2018-07-18" version="1" fragment="single">AILPPLMPPQDSMQDPRPELPRPYKCPMCDKAFHRLEHQTRHIRTHTGEKPHGCTFPGCSKRFSRSDELTRHSRIHTNPNSRRSNKNQQQAALAAAAQAAQHDHPSIGSPGKMMPPPPKIISKSAPPSHVGSPNVSPPHSYHGMHQPSIHSGLTPFRTSSSPSLMGGKYNYGLDLGFLAQTASQQLERERHHYHLQHHQHSRPPLPSFSHGAQPMSRSHSHEDDDPYSHHRSVKKSRPSSPVSTAPSSPTFSHDSCSPTPESTPLATPAHSPRLFPRDRDDYQMQLPSIRHLSLRPVPPLAPMEIADPYNASGNMTQPPHPSHGIRLGDIINRADGSQRKLPVPRVAVHDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCM0</accession>
    <name>A0A2T6ZCM0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1095515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000397">
        <property type="protein sequence ID" value="PUU73238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCM0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCM0"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="264" mass="28545" checksum="0C3417C8D6EC6202" modified="2018-07-18" version="1">MAEPVHSAEGGTAETPNTPSASVDVRKARKAFIPLECNPELMTSLVHKLGLSKNLAFHDVFSISDPELLAFIPRPALALLLVFPVSESYQQHRIAEDAGKEEYSKQGDGEDPVWFKQTIKNACGMIGVLHAVCNGAARDMIGDGSSLKELLSKALPLPPLERAQALEDSQELASAHKSAATLGSSAVPDAEADVDLHYVCFVKAKDNHLYELDGQRKGPLDRGDLGDCDVLSEQAVKVVQRFIDREKESGRLEFSLVTLAPGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCX7</accession>
    <name>A0A2T6ZCX7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1035320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000395">
        <property type="protein sequence ID" value="PUU73264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCX7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCX7"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="105"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="749"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="11">
        <location>
            <begin position="871"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="541"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU73264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="984" mass="109166" checksum="9E7365EF10425B16" modified="2018-07-18" version="1">MAALQKSALSPMDPNLPTRPLVRKRSARATNPSPLRKQSDYQLVAPLKITPATTSGPPPAPSSTANQKRSGDPKTPKAAAKDRKKKLLCATPPQVLQDTRGRAEYDRGRQLGEGGFARCFLVQNKEGELFAAKTVAKKSLQNQRMKAKFFGEIQVHKTMVHPNVVKFVECFEDCDNIYMILELCPNKSLMDMLRARKRFTEPETRFFLLQLLGALKYMHGKKVIHRDLKLGNIFLDADMNIKIGDFGLAALLVNESDRKRTICGTPNYIAPEVLFGSGKEGQGHSFEVDLWGVGVIMYAMLVGKPPFQAGDVNVIYQKIRHNTFSWPEEVPVSSAAKHLVHSILNHDPDARPTLDDIADHYFFKSGFFPRMIPVSAGKQPPVWRGASGQGVGAVSTNRQDWIKNYEEVARECGIGIRSDGRPVSAVGDHAGESMELLTLPSSRPASVLSTRDENQQFAVEKQTVKIKPEDEAKKQKQTDAYILPETLSPRDSHARMRGANALKGKASRLWGPTRGTGLISAGLMPARQAPGLPASQVTKVTEVEEGSDDDFEDQEEEKPIAKPSAQRLKAQPIRRSTVVTSPVVRKSVFPPRNQAVKSHAAELRAASQPEVHEQPAKAPPTAMAPKFQGRLQSRPSRPTSSASAKLHYELPPSSQELVISARSSSQQSSLPSSQPSEGPIIPFGPNLSSKIGVSIRSTATSTVLSSLRPFINSLEAFANSRLHTLSPTPAATIAAVKSSRRGESNKHVFITKWVDYTNKYGVAYILTDGTCTAMFNDNTSFVVDSIGGERVEFITQSYASDSSQDTVYRRLQTKMEVLNEKKRTSKGLARKMQMWKRFKNYMKTDLETVEQWSVERDSVIREPTVGGDDYGMLFVTHYTRLKRCALFRFSDGSFQLNFIDHTKLIVSSGGRTIRMITKAHELIVMSLEDTHQEVFTSKNRGLLDFGVREKLNYLVDILKLWAAEGKFPRNYDVKEETGITVLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCY7</accession>
    <name>A0A2T6ZCY7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1095458</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="NESQ01000394">
        <property type="protein sequence ID" value="PUU73274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCY7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCY7"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="863"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="29"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU73274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1137" mass="124482" checksum="B282A034D28C60F2" modified="2018-07-18" version="1">MSSNKKQTTLGYVKSQTTLGRFFNLSLSTNAAAPTQSKLKLINKPGKPADSDDAASPKVKKAPVKGAVRGKPAAPENDGSDSDERDMKAGVSSEMEVSDTSEPAIHSSKEEKAVGNSPTKRARPTEPPFRKRGRGSSIIKKEAGVSEDGLSPPSKRSRKAREKSCDNVKSSDEDIVPKRRLPRGDPPKTTTKKGKGKAGVNIPASPPKTTRKAKSSSASPPAVSKSKSKTRTVQKSPPALPCESIDSGLSLPDAPSSKSKKSKPKPKTGIDQKLPPVSPCESTDSELSLPEASLSKSKRPKSKPKTGIDQKSPPVLPCESTDSERSLPEAPSSKPKKSKLKPKARTTKKKSPPIPPCELTDAELSPPEAPSNKPKRSKSGSKDRTVEKSPLVSPCESTDSELSLSETASRKPKGSKSKSKSGATTKSPTGRKSKKRVVASDTEAADKPESPATRKALDSDSETEKPSLAPSAGREMIKKLSQSVPPAYPDWVAGKPTPYAALVTTFNLLESTTKRLEKISHTSRFLRQVLRLSPDELLLVIHLMINKLAADFEGVEMGIGESLLMKAIGESCGRSMEGIREDQRECGDLGLVAMKSRTKQQTLFAPQALTIPVVHEGLLSIAKVKGEGGQGRKVSAIRKLLAAAKGDEAKFLIRGLEGKLRLGLADRTVLVSLSSAMITHEQELCGKMPTTAMLDLSELNLRSVYSELPSYEIIIPAMIEHGIMNIKKYCKLQPGVPVKPMLAKPTKAISEVLDRFENQRFTCEYKYDGERAQIHYVSPKSSIEYPPATLGGEPIKNLAKVFSRNSEDLSGKYPDILAAMNNWVRPEVESFVLDCEAVGWDETNNRLLPFQMLQTRKKKDVALKDVKIRVCVHAFDLLFLNGKPVVRESLNDRRKLMHETFIEVPNQFVFARYMDSSDLEEIRLFLDQSVKDSCEGLMVKMMDGSESFYEPSQRSRNWLKVKKDYIDNLGDSLDLVVIGAYWGRGKRTSVYGSFLLACYNPGTQNYESVCNIGTGFKEAELEEFYETLHPLEIDRAKPFYDHPSGNASKPDVWFEPKVLWEVKAADLTLSPRYKAAAGLAGHRDKGVSLRFPRFIGPRTDKTGENATSSGQVAEMYLRQDQVAHKTGAKGVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDB8</accession>
    <name>A0A2T6ZDB8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1004396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDB8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDB8"/>
    <dbReference type="OrthoDB" id="4505337at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="259" mass="29045" checksum="8943CDB9ADD1B4D0" modified="2018-07-18" version="1">MVQSSVSVDNEREDGCTILVPGFHRNIRKWWSRVEARDKAANGLTTCVSKIYTADDEEAFGRFIPTPCPRGGIRITRSDILHGSTRFARLRRRTILPCFIAVSPDYEKLENEECEAWTQLSTCHRVMEAPKRSTSGFGFAYGGPGYRFPPGVLLESSSAIGDALVCARRWDDALVIEELKILLGPNDDRAQQYVQTIRRRLVENYIRAVKAFFEMERQQYGTKSFALCGSLPDSLRDQEGGYTDLWSTDSDSGAVSPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDG0</accession>
    <name>A0A2T6ZDG0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1103914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000371">
        <property type="protein sequence ID" value="PUU73509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDG0"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015625219" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="83"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="381" mass="40902" checksum="3FB3E035B307683D" modified="2018-07-18" version="1">MFLKSSLTTSFLFLSSQVFQSADSRKPEHIFLGISAAKIACFDIRTTGSEYNHLPRDPEFEYLRTINFYQGQKLMIALSDHSAWATPECIVSPRSAAEVSSVLQAITAADAPFAVRSGGHSPNPGWSNIEGGVLVELSRINEITYDPVSTNVVVGTGNRWGAVYAALEAYGRTAVGARLSPVGVGGFLLGGGLSHVSNEYGFGCDNVVEYEVVLANGTIVNASTNSHSELYWALKGGTNNFGIITRFTLKTIPMSKIWGGVITYKATQAPAVMDAIHSYHAGHISDLKSAISVQFILGAGVVLVTLMYAENISSSPVAFAPFDALPHVASTMGSKSFTEFHDEWLVGGNANRYGFRESRGGTWIRACTKTSSQSPQTPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDS8</accession>
    <name>A0A2T6ZDS8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cohesin loading factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1094612</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000357">
        <property type="protein sequence ID" value="PUU73645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDS8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDS8"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="711" mass="79122" checksum="5AD195889A08B0AA" modified="2018-07-18" version="1">MTTPNGGRWYNSGPGPSYNGSNNSNGYGSNPYPPSTPIAPGRPQQSASTPTRPQLPPPSINRYSNFEITIPVNRWPASHSNSNTPNTPSTPSNSMDPHLTLISMAEGYFEAAHASGYKAALAKGGEDAKAYYKLIATGLRALEAALQCRLQPRLEAMVRLRYAGILHEETENGDEAEDALNKGIMLAQRGNFTDIKYTMQHLLARIMLRTTPKASLKMLNSCIADSETLDMVHWTYSFRFLRCNILMEDSPLHDEQGAITTLQKISSTAATRHDHGIYLLASLMETMISVSSGADGIEAANRALARANSLQLESIQGMEQLGILRQMLDIMCSLMAGRYSESEVKVKVLHGMLDHSSKAQIWTPSGEFEILINPLRLGRPEEKLKFKWLTKEDIFVLGYFISGLCKFQKNVEEVGRGEKYLQEGLRSIERLLKEDHAGTTSLVGAMNKSTWRQTLKCHVMLYHTFLLCVRTDWDGAIKGFNNLQQAFLVLPPQRSLLPTLITYLQAVISQGTNQLDQALELYKLVYTTVQSPDSELSIISKLNSIIILRPRDSRAAEHLMTTVEKPCMSTKNYLMKAAYMAVKATERGELVKTKNYLSLALQLATQTTNQQLTFILLSFMCHRFFSGVVSEQAEKSARAALQNATRGRDSLWSLMGGEMFADCLARKGNEYEAMRQRDLNEEPRNAVVANLTRHTPPDQHASGGVGFHEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDZ5</accession>
    <name>A0A2T6ZDZ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000350">
        <property type="protein sequence ID" value="PUU73718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDZ5"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="120"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="244" mass="28685" checksum="B78307EC16255D7A" modified="2018-07-18" version="1">MSKPQSWEEKRNVHLLEWEGDHDLVLAGIVASRGITFNHLWRMVPEVFRFTMIDFWLFYEGGTMVPMNNDQLPAGRYFIVTNGNIIRITDPIITSTPTAQNHFNRSGRFRNDVRTRDGRCVVSGCVVPRTMEYDGYEAAHIYPIAYHHNWANDSHQFKLLPEGESIDSMRNGIFLREDIHTLFDRFIFSIDVDDNYKVIYFRIDTRGIAGNRLPQSFIDNPHRPSDNLFRWHFKQAVLRNMRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE47</accession>
    <name>A0A2T6ZE47_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000348">
        <property type="protein sequence ID" value="PUU73749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE47"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11132" checksum="D77D36FA20780CD9" modified="2018-07-18" version="1">MSTANILGYFRKHPRLLVIAGGGLGLLYNERTTAHAMRNDMSVMMDATYEKLGESLVSKMDVIISGIKLERTGTPPTSLASSQTMILATSSEHSTKQSSVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE49</accession>
    <name>A0A2T6ZE49_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1003502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE49"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="331" mass="37682" checksum="52B0A2D331D867FE" modified="2018-07-18" version="1">MPDDCGRLVSVLAFYVFSCSCFHASNKRSKPSRNTQSNWKEEIENGPSLFRRRNYSHGSSRHSSPRGQSPAFGFYTSRNNATYSVPSTADSTETERPVHLNNLFSEVEEKRTKIERITTVTVTQLPRIHPPVNEYHPPVVSALPDRRMDTAWMRLPPPTARAMRAINRETHSRRDSVRDKYSSTNDVTSDIHQLESQSIARNKSEEWRTVGDSNPANGTGSKKPEGTVGKKEMSEGAEEEGEEEQQHKVPEILSEEHWLKRRRVFTSLPGLNGRRSVEIDGSIKFDQDQESPYHSAFSQPAEAIRRPAQVFTRPYPLRSISSDLDDNFYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE92</accession>
    <name>A0A2T6ZE92_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1002980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE92"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE92"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="181"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="323" mass="35956" checksum="FCC5359CCED9E132" modified="2018-07-18" version="1">MLIGICGSLCAGKTEVAKYLETKHNFTVIRIEETNNSNSDGGRNCASWTDGEKSYPSCKSLLDYITRHWSKRFVILGMGLVEPKALETFLRRPFFLLLSVDAPTLVRWQRYQKRAGSSSLKQTFESFVQECDTDMYHPDHGIAHLVQKSTVRLLNTTDSLERLHQNLDALKLEDESRLRPGWDAYFMQLASLAARRSNCMKRRVGCVLVRGKRVISTGYNGTPRNLVNCNEGGCKRCNNGTEGGVGLMTCLCIHAEENALLEAGRERVGDGATLYCDTCPCLTCSIKIVQVGITEVVYSHGYSMDAESLKLVGSNLQSSTLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF34</accession>
    <name>A0A2T6ZF34_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1093737</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Nibrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF34"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF34"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="24"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="388"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="699"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="741"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="809" mass="89823" checksum="E2B34997DF93401C" modified="2018-07-18" version="1">MWFIECEGEVLGGKRLWLRPKQRFAIGRTPSQDVNLSLPSQKSISRIHLLIEVGDVKEGDGLKLNVRPSLKVTDHKTKHGTRIDGQEIRDQAVTLDEESYHIHLGKYEPAFRLYWDPIVFSVSLSSKDRKDKRSMIPYQNKVEALGIKTLATFVCSTTHVVASKRNTAIGLQALINGKSIVAGSYLDAVAQAASIPQDGRQSALEQDFDANWPNPEEFLPPSNNEPGNPPSSLYKPDQARRNLFEGYTFIFCDNLQYNNFLGPVTDAHGKLERYDVRLGETTPEELVEFVRKRGHGTNVAVVRFIAKKNPEWENHLSTRVQEILGYRMVEQNEFLDIILTGDTSRLRKPLDEDFSPIARQIASESPQAPRNVYNGSPIQLEKSIIEETPLPPSSGETSGASRPALRGRGRTRTRVIPKLIDPFSMDPLDLPPPASAQVLSASTQLTSGQGFSTPAPRVIGASAQSESSLSRPSASFSNTPVETNEPPHNAHLEAPLDPRSRKRSVESEDEQGQPLDIMDLLPGAQAVKRRKLIEEEERALRGESLEESPPEPLPKPEPANKMPDKTLPLKGKGKKVQKGENPFIIKAREIKEKEEEAARVAKEEELTAMEGLDVDQLKNLAIVEVMEVKPRTDKPSRDGYGDQGARWEDRWNGRKNFKKFVRSGRGGGMRAMRSHVMVNLVEHKGRDYGIGDGYWLGNEGETPSAKKNQKTPAQRLRQADDFQEDNNDSMQALSPGDRSGAQAQGTAQAHTLATRTRGSAITGQGTKRGAVAQGSRAGAGKKQRTLVLRDESGSDEDSDDELRFKFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF37</accession>
    <name>A0A2T6ZF37_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1001802</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF37"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF37"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="219" mass="23672" checksum="ECCE842F604F0887" modified="2018-07-18" version="1">MSHARASAQSQRFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTIALDEATTIKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKAWVKELQRQANENIVIALAGNKLDLASPTGSPSKRAVETTEAEAYAREAGLLFFETSAKTAENVKELFTAIAKKLPLDQQGPRGATRTGAAGGRGVNLSSANAAQQHGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFB6</accession>
    <name>A0A2T6ZFB6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">B9Z19DRAFT_482653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000322">
        <property type="protein sequence ID" value="PUU74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFB6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFB6"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="417" mass="45931" checksum="1260F348781ECE0E" modified="2018-07-18" version="1">MSIEVNWETLTSGPDGARYAENIRSFVHEKFQSIPFPKFIKSVNVHSFSFGNVPPDIEIKELCDPYPEFYEDDDDEYSDSGSADMSSANAGGEDEQDYLLKLERERRRRERRDDGSASGGMRSPPPGLNPPPYTPDGRTGIPFRSPFTPGIPDTFPGRVGVAGVTTPLFHRGGSSSNLHYFHSALSSGFTGANTPALSAFQSSSSPAPPESQPRSTSTSSIPSRPSTADSGGLISSLNITDPPSVGSSSREPLHTPTSEDSRARRSSSPAIPRLTEPRDEDTQIMARVRYSGDIRLELAAELLLEYPITNFVALPVRLVVTGCKFDGLACLAYIRRRAHFCFIDEEQTSDLGDGEEVARVRTKSLLKEIKVESEIGEKGKGKQVLKNVGKVERFVLEQVRRIFEEEFLFPSSWTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFE7</accession>
    <name>A0A2T6ZFE7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1133725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000316">
        <property type="protein sequence ID" value="PUU74199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFE7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFE7"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="14"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="357" mass="38234" checksum="F9DF12F1B56A5836" modified="2018-07-18" version="1">MSIPREQYAQIYKDNNHPIEYKKVPVPKPGPDEVLINIKYTGVCHTDLHAWKGDWPLRTKQNLIGGHEGAGVVVAVGELVEEIKVGDHAGIKWLNGSCGHCEFCMAGDEPLCEKALLSGYTVDGTFQQYAIGKAVHVARIPKEAPLDAIAPILCAGITVYKALKESNVRAGQTVAIVGAGGGLGSLAIQYAKAMGFRVIAIDTGSEKQEMCLKTLGAEEFVDFAKGDIVANVKSVTGGLGAHAVILLAVSEKPFQQAAEYCRSRGTIVCVGLPPKARVSAEVFSTVIRMITIKGSYVGNRLDTQEAIDFFARGLIKAPFKVGKLSELTKVFQLLEEGKVAGRYVLDTSVSSINHILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFG0</accession>
    <name>A0A2T6ZFG0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1093361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000314">
        <property type="protein sequence ID" value="PUU74225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFG0"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="197" mass="21727" checksum="EED4B69B900F2133" modified="2018-07-18" version="1">MALLGVYHLDQPIPSSSSQTGPQPLTLLRYLSTTLLTTHSLPHILLQKRHKDVSLPPPVWGLDEGVEGVLVGLGSNAEMVVEMEYRRKSGRAVVEWFVIGGGEKEGGKDGVILLEDHPLWRVSEKVRIEDSGEREGNDGIDGVTFELGITERQRRVREGVQLPYMDAQREGGIGGGGAILFTPEKEVDDFDEEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFT0</accession>
    <name>A0A2T6ZFT0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromodomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1133475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000306">
        <property type="protein sequence ID" value="PUU74329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFT0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFT0"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05500">
        <property type="entry name" value="Bromo_BDF1_2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="260"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="479"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="666"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="625"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="741"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="88434" checksum="5A52B0E39A0E3F10" modified="2018-07-18" version="1">MAVMSPQLSVNTQSSELKTEAAAPALASAVDGSAVSEGAMAMDLDFNGSIKQDDSTSPQFAPSSPKDDHVSNGLRTPFVNGSAPDAKINAPPSPPIPTPPLHSDNTHDLSDLHITSPAGLPGSTVMSFQGGVGSEDKEKPTGELMDQDASGDNPKNDEKSDEGKGIGSNRSEPPQKSESSGSLAGSSHDTTTDRTMTDAPTLKTSRSRDDDDGEGPPLKRAKTEEEMDVVSPTTAASYNSAAPLTVTQTKFLAGVIRSLRRTKDARPFTMPVDPVKLNVPNYFEVITNPMDLHTMEKKLNNKEYSSSREFLADFNLILTNCVTFNGREHPVAESGRVMKAAFENHMAGFPPADFVEPQKSKSSKKKGGGNTATKAAAPKPPPKPAAPVPQTIKATQTKKESKRPAPAAAITAASPTFGLQPSGIPQIRRDSTANDRPKREIHPPAPKDLPYSDVKPRRKKTASELRFCDIVLKELHKKQYHDMAFPFYVPVDPVALNIPDYFKIIKKPMDLSTISTKLKTNQYDSASDFEADIRLMFSNCYKFNPSDQHVHKCGKALENIFDQKWVEKASYTRDNPGSHSPVSVSPPVEDEDEDMSGEESEDQEQNIRMLEQQLEAMKDQISAMKNGQKKKKTPPVASAKKSKGSSSRKNSLASAPPPANTSRPKKGKKEKKVPYITMEQKTELSERINFLPTGKMAYALKMIRENMPDLGNTADDEIELDIDELDPQTLYKLHTYVTRHAEKKPSGYVPPPPPLHQSQSQKQEAKIKDLQAKLQNFDNPTPQPSNSAANGDDSDSSDDDDESSGSESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG30</accession>
    <name>A0A2T6ZG30_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1056262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000300">
        <property type="protein sequence ID" value="PUU74429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG30"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG30"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="144" mass="16025" checksum="5F49E5B54160CA29" modified="2018-07-18" version="1">MAASTQSVQCFGKKKTATAVAHCKKGRGLVKVNGAPLSLVKPEILRFKVYEPLLIVGLERFAEVDIRVRVSGGGHTSQVYAIRQAIAKSIVAYYQKFVDEHSKNQLKQALITYDRSLLVADNRRCEPKKFGGPGARARFQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGZ7</accession>
    <name>A0A2T6ZGZ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1092084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGZ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGZ7"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="124"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="388" mass="43273" checksum="FC70CBE61BF7CB8A" modified="2018-07-18" version="1">MARDLFKKAYQPLVALGASYFVVLGLLMVPWIQNNAIYMHRMKITWRQDLTKPEEFGFAKNQVAPFFLKTPDGEDIFAWHVLPLGLYKEHRESLTKQNTGLITNPLESENIKLLMADPEARLIIHFHGNAGTVGASWRPTYLRSLSAGDPSKIHIIALDYRGFGLSSGTPSEQGLIMDGITAVSWAVNTLGISPSRIAVVGQSLGTAVAIGTAEKLATHPTNPIELAAVITIAGFSNMKELILTYNIFGWLPILSPLRPYPFLQRFFTRFIIDTWESDRRVASLIKSSKKLNFIVLHAYNDFDIPWQHSDRLFVTAANATQPGNELTWLEIMGLKEKTEFGEESYQNKWPMARSNGHSIEQWVVRWGGHNQVVASAGVSVIVAKALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHY2</accession>
    <name>A0A2T6ZHY2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000255">
        <property type="protein sequence ID" value="PUU75024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHY2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHY2"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="40"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="28165" checksum="269D8DF809A153C1" modified="2018-07-18" version="1">MTIIGARQWADGPFPLIKTPAFDGDPKDPFIKAATEMALIHNVALRGMNSIYLQAPHVPAKDVQPFIGYCKAWSELLHSHHESEEALLFPSIEKAAGVPGLMQTNVSEHQQFRDGLGEFDKYLDTATPETFAGQKLNGIIDTFSGALVQHLTDEIPTLMALREYGFEKVPITQLIDAEAQHQMGTANKTTALAFLMTALDVTYEGGIHKNFPPAPAPVLWFLRNVCTLPCRAYWKFAPCTAGGKPRELYLGDRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI93</accession>
    <name>A0A2T6ZI93_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_995607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000243">
        <property type="protein sequence ID" value="PUU75218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI93"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI93"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="522" mass="57408" checksum="63FBA063F0AA6F08" modified="2018-07-18" version="1">MDPEKAAISPPPVPPETIGAGAIPVLPKVQTRSHHEDIELAIDSGAPSSIGGEEFEVRWIGEDADPLNPRSMSKSRKWLAAWVVSLGGACVTCTSSMYTSTYRQVTAELNVPQLAAVGGLSLFVAGLGIGPLFLGPLSEFYGRRPIYLASFSLFTLFLLPCALARHIAVLLVFRFLTGMAGSAFLSVAGGSMGDMFNKAEVGAPMMLFTAANFVGPGAGPLIGGFINQNINWRWTFWVLMIWSVFMLASLYIFVPETYHPVLLRDRAVSLRKSTGDPRYRAPIEKMSRSITHTVLWSCIRPFELLIFEPMLLLLGTFTALLLGILYLFFQAFPLVFANVHHFSLQQIGLTFLGLIVGMCLGILTGPIWRKHYAHLVHKHNQISQPEFRLPPAIAGSLLAPIGLFWFAWTTFPHVHWILPVVGSGFFGMGTLLVFNGIYTFTVEAYPVYAASALAANSFVRSAFAAGFPLFSTKMYERLGYQWASSLLGFLSLAMAPIMVCFFVWGEEIRARSRFATVRTQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIE8</accession>
    <name>A0A2T6ZIE8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1090693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIE8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIE8"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="352"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="561" mass="63808" checksum="9FBC6AA08B8591BB" modified="2018-07-18" version="1">MEVAGLTIAAFNEVFVIGKFIRQVLIDARDQDNSFRKLESDFEHQQILLSTFGRRYLESRSISKIEHSLRDQIRKILGELKRLVGEYGRLAARYDKEYAKALEGVDKWWETGIGSSGKPKDAGELKVIHLESIEIPGPTKPVAHEKKHAQGGLHLPRAQFSQKFSSLQWALSNRERLESLVREHGDWVGKLVEIIKLDHFTRDGFSSNLSELENFQRKDAKALGMSKITATRMLFLDPSQGKRVKLKSKLITAHAPTNAAPPIGEGDLRNGKYNNQNVLIEYKSYPENSSDRVLEIAKGRIQFLSKLLGVECRNGEPTRSNDFTLRCLGFFHKRRERLYGLAFALPQDREPEPMSLHTAIGSLKRQSRPTLGQRFAIAHNIGYTLIEWFLVGWVHKSINSKNILFFHQESQGLDFDSPYLCGFEYARPALDGTIYSDNGGSKGIHWNIYRHPDRQGLPTEAFRTIHDIYAFGVLLLELGLWRLAPELLDPTAKATPRVIHKTLVRNARERLGHFMGQNYRDAVLLCLESSLADELDDQKGSRLIATFKEKVVAILEEGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIF5</accession>
    <name>A0A2T6ZIF5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_995269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIF5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIF5"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="348" mass="41026" checksum="B528E45C0E15CBD6" modified="2018-07-18" version="1">MRPFEVNNDRLGVLHGLTQDSAPPRTNKPPASPPKSKSRPTRAPPPPEKEDRTPQSKSDDPSRPRKTKFRFKRKRQKDSHHGSSSSHSHSHSSDRRKRSHHKPLDDDPAEYDDTYIPNLASVNFTTAEDAFRESLFDAMADDEGAAFWEGVYGQPINIYPRPDGRGELEKMTDEEYAEYVRSKMWEKTHEHIVEERIRREEARRARRQRDKEEQKMWEDAERSKRREEKERRRLKDKTRIEKQWKGYLEKWSEILAGKVDGDIPWPVESGKLKDIEKVSLERFYMDIRGSLGEGEDLLDVLKVERIRWHPDKAQQRWGKRGLSEEEQRGITAVFQTVDSLWVEYKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIQ1</accession>
    <name>A0A2T6ZIQ1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH:ubiquinone oxidoreductase 30kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_994989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIQ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIQ1"/>
    <dbReference type="OrthoDB" id="37721at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.80:FF:000002">
        <property type="entry name" value="NADH dehydrogenase iron-sulfur protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="entry name" value="NADH:ubiquinone oxidoreductase, 30kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10884">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="Nqo5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase 30kDa subunit" evidence="10">
        <location>
            <begin position="114"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU75375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="277" mass="31350" checksum="3A01D36986E85A8F" modified="2018-07-18" version="1">MSLRINSSSTIVRSLSAGARSPAIRVAPTIATRTWYSGAKRPDGTELPNIRKAERPPIGPLKAPIVNPADKYKSTSESLHAYGRYLISALPKYIQQFSIWKDELTIHIAPSAILPYTQVSDITAVDYPTRSNRFEVVYNLLSIRHNSRIRVKTYADEASPVPSITGLYDGANWYEREVYDLFGVLFVGHPDLRRIMTDYGFDGHPLRKDFPLTGYTELRYDEEKKRIVVEPLEMTQAFRNFQGGSSVWEQVGSGRDDKPDSFKLPTPKPEAEPEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ19</accession>
    <name>A0A2T6ZJ19_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_994408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ19"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ19"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="100"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="411"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="632" mass="70010" checksum="EBAD425FA0C4F2EA" modified="2018-07-18" version="1">MVSASKAKREAERAAKRAAGGGEDKPKKTAASKLAVTPGSSRAGSKATSKASSVNGEAVEGTDEKALAKLEKLALQEDEHGLSDRVTTGVLSSLESSRDAKISSVSLVFHGRVLIQDTTLELNYSRRYGLLGENGCGKSTLLKSIAKREFPIPEHIDIYLLNEPADKTSLGALDYVVTQAQEELKRLETLAEETLETDGHDSPILEDLYERIDSMDPSTFATRASLILTGLGFNPVTMGKHTKDMSGGWRMRVALAKALFVKPSLLLLDDPTAHLDLEACVWLEEYLKKWPRTLVLVSHSMDFLNGVCTNMIDMRMRKLIYYGGNYDAYIKTRSEQETNQMKQYHKQQEEIAHIKKFIASAGTYANLVRQAKSRQKILDKMEADGLIEKVNPDRVFSFRFADVEKLPPPVLSFDDVTFSYSGIAKDNLYENLDLGVDMDSRVALVGPNGVGKSTLLRIMTGKLQPTSGSVSRHTHLKLGMYSQHSAEQLDLTKSALDFVRDKYREKSQDYQYWRQQLGKYGLSGDSQTALMGTLSEGQKSRIVFALLAIESPNMLLLDEPTNGLDIPTIDSLADAINAFDGGVVVVSHDFRLLDKIAKDILVCENKTVRRWEGSIGQYKNHLRKKMQSTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ73</accession>
    <name>A0A2T6ZJ73_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1131140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000226">
        <property type="protein sequence ID" value="PUU75540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZJ73"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="907"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="150"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1102"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="725"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1501" mass="165707" checksum="EE345A1F5B6B78E5" modified="2018-07-18" version="1">MVEKSSIQNLRNNAVSRRLEEQKNLIISRKRKLQEVYAVCRHIDRTKPFPNADIVETWGTIERYEGANMEDGEKRFLEENDIERGRFFREPTLPPHSSYQLTSHYAVKPISHHATPLSTPVLEKPPQVLEHPTVSQEAELLAEKEVRHTFDARKRIEDQSSTKSGATNGKRSSEAPTEDGSVDSEATEEDMGSLSHAIEPSERVKLGNAAPVVNVGGVPVVQETTTRVPDDHERSLGVRPPPIPSELVNAAKGSTIQTTASRDEKTKERDTCTEKVTSTESTAVKSFGDYACEVPDSFESSQVTSLSEPPSPAPSKGTILELREEPQLPVTPPQIQQTPPQPPLVIITNRENRPSPIPPSRLPPGHASHPDAYSPTSSIDGDNRSTPSNIISSATSPDANHILGSDPRSEEINGQIKEVVAESGPYGVMTMPAKEAEQEELAGAFVGKRMAPCEAQSEKSLPSVLAAQDVIADEKEVQSQLPISPQELTNGGELDLAAVEAGLASTIPEADEAPQSAGTKKSASPDPSAQLRLENSLAQDDVVKPDSLADERPHSSQKLAGAGETHDEDLEDQVQLVGSREPEPRAAVSTRELTEAAREVRDGTENMEIDVPDRVGDIGATSHDAVMSGVDQPVVHRTTSGTHVGDISISTIPLPEQQSLEASTLQEIDDSKMEIDHTANERHDEAGPPDKVPTPDANTLADAGTEPPGSPADSMLGRGDKEEVPTTGEVVVGVAESDSSLIPSTSLAKQPLRRRETRKKQAKLSKVVISSTHHALAALKEEAKRLHEDQIAQGPIVVARRRDQQAASAAARRSAVFQPGSKIDAITRYGIAEPPSKEKSKVKNADMFDVAYTAKASGTLISELLQRSSKTLTTDDHRVHYFETQAVRIENRILELQDQGLWSLRQIPRVAEPRRRKCHWDYLLEEAKWLRDDFKEERKWKIAMARYYAKEVARWHRVGEGRCQLQIDRKRLGVVPKGIREERKRAAYVEMQDSDMNQPTPDLIDGCGSPESDDDFPMDDRHHDADQGNFAHIYEPPATLFTLSPEETVFAMPASKAADDILNQLPLYGPPEPPIGRHEEVEEEWMKIPVVAISKYASGKLVIQEEQGPPPSKKSRYEYEENQDPYADDSDEDEKLGGGGLIGRSERDKLRKPSFLPPEQTNVALFKPEYKPILQRVHSTHVPRLPSDFPPPAFFENRHPSLWLPSEDEMLKTLVREYHYNWGLVSQCLTLPGDWHSGSERRSPWECFERWIALEPIPPEFAKSPHFKPIQQRLDVAARVNGLYGNVPGSAGGNGSGGVKPRRGTAPIRVEKRRNTRNFALIESMRKLAKKRETSVNKQQTNKNQVVAAMRRASESQASANQLRTPQYFSAMKFEREQKHLEQKNIYSQHVQMQQSRNGIPPQARIPHPGQHHGLANGVPIPVQQRVGIPAPQGPNGVLQVPRVAPMQNGANGVPMRSLPPQLSQGQTQRFTPDQIAHFRRIQQTAAAAAMASRGYPSSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK96</accession>
    <name>A0A2T6ZK96_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B9Z19DRAFT_1029900</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK96"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK96"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="88"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="235"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="494"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="594"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="676"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="723"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1106"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PUU75917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134511" checksum="0E7F28EABF55A8F5" modified="2018-07-18" version="1">MPPRRAPSAAAVAPSASASASTASTQPKLKPTRAKVGGIDGSEATTKPVGDSFDELLRTYYKGKHLADSINTAEDKWTLLPMFLKVKGLVKQHIDSFNYFIDVDLKKIVKANERVLSDADPQFFLRYLDIRVGTPERLDIESNAEITPNECRLRDLTYAAPIFVDVEYSRGKQIVRKRAVNIGRLPIMLRSNKCVLSGKSEMSMARLNECPLDPGGYFVVNGTEKVILVQEQLSKNRIIVENDAKKGIVQASVTSSTHERKSKTYIISKKGCIYLRHNSIVDDMPIVLVLKAMGIQSDHEILLLVAGTDMVYQDTFSVNFEECSKLKVFSQQQALEYLGARVRKQRFIGPMKQRTTVQEALQCLADIVLAHVYVENLNFRPKAMYLAFMARRVVMAMTDSSLVDDRDYVGNKRLELAGQLLSLLFEDLFKKFNSDMKLNIDKVLKKPNRTEEFDASTLLYTGANLITHGMNRAISTGNWSLKRFKMERAGVTHVLSRLSYISALGMMTRISSQFEKTRKVSGPRALQPSQFGLLCPSDTPEGEACGLVKNLALMTHITTDDEEEPIKKLVFALGAEDATILTGHELYAPGAYIIFINGTLHGLTRFPMKFLRSFRKLRRNGKISEFISIYVNHHHNGVHIATDGGRICRPLIIVENGRSKVTPRYLKSLAGGRTVFEDFLKKGLVEYVDCNEENDAYIAVYEQEITESTTHMEIEPFTLLGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIAYNQFLRIDTLLYLMVYPQQPMVKTRTIELIQYDKLPAGQSAIVAVMSYSGYDIEDALVLNKASLDRGFGRCQVFRKYSTILRKYQNGAADRIGDIKRELSKDPENPDELVPIRKHAALQADGLAAVGEKISAGEVYVNKQTPVNTSNTPTLLSDGPPLDEYKDAPMTYKLYDHAYIDKVLVSTSESEQTLIKVLTRQTRRPELGDKFSSRHGQKGVCGIIARQEDMPFSDMGVIPDIIMNPHGFPSRMTVGKMIELLAGKAGVLSGKLQYGTAFGGSKVDDMANILVNNGFSYSGKDFVTSGITGESLEAYIFFGPIYYQKLKHMVQDKMHSRARGPRAILTRQPTEGRSRDGGLRLGEMERDCLIAYGASQLLLERLMLSSDVHEIDFCEACGLMGHSNWCVTCQSSKGVVKMKIPYAAKLLIQELLSMNVLARIRLEDVFPYGQEKQVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKE0</accession>
    <name>A0A2T6ZKE0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chitin synthase III catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKE0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKE0"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="32062" checksum="0DF2C19790558586" modified="2018-07-18" version="1">MSQFGDFHDFCRDSTLPVCNLFPHERHCALNGFRVGDGGVKNLGSIILCALAIIVSVLLLLLSQKKRAAVGRREMQIFLIFYILVSLVEIFTVGGFLTNRKVLVWFSGIHLGAIAATAWVLLLNAVVGFQLIDDGTLLSVGLVVGSALAFFFGTAYVALDTGFDKTGNFPMKNTDQLKNYALYVLYLLFPLVAIVAFFLLETFLVLKVLGEVMPMVRLGAAALLFAIGQIFNFVISVHLCRASSGKIDGTLFETLFTLLAVVAVWFFWSSITEDEWPDDHPMSQISEVYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKH0</accession>
    <name>A0A2T6ZKH0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ATP synthase epsilon chain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKH0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKH0"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="65" mass="7289" checksum="0E53A8D2C4AF1176" modified="2018-07-18" version="1">MVAAWKAAGLTYNKYLSIAARVVRRSLKEQPRLAAERRGDMQLKFAKWEGGKQGEVKSLAKEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKQ4</accession>
    <name>A0A2T6ZKQ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000203">
        <property type="protein sequence ID" value="PUU76079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKQ4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="27866" checksum="9C707423D6B6ACA5" modified="2018-07-18" version="1">MAQQKDLTIPSADLPIQVAGQWYSSPERYARLNNNSYKADIFFASLNPASGEASKIPKKDCYPLPISQYYLLGPPPGGSYTHVAPSGKRSGKPAMAAQVASASALQGVEAPKPPPPLLGTQHRFYTLHLLPSFFDDLLNMAASLPDDMASVLNSEGCTLLLSFAALVNTNRASKITTSVFIAVTPQDPNLLGPDLQHNGARIRLFNRLEDIHLAHPASRNTQYKKCYHFGHSKPVYKAEHYTCPISAKVHLRAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKT4</accession>
    <name>A0A2T6ZKT4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1088990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKT4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKT4"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000006">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000844">
        <property type="entry name" value="Nuclear GTP-binding protein NUG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="182"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="536" mass="58857" checksum="ABFB6B96E261F7B3" modified="2018-07-18" version="1">MVKPRKKSKRVPVRLRHKIEKRSNEKARKERKEAKKHPELHRKKKNDKLNIPNSFPYKDRLLSEIEEGRRLKEEEQLRRRELAKRRKEELVDGAQGKEDAMQIQGGGDESSSEFYSDVMDEDDADAGTGGSAMAALLASARARASEYEAEHGVFSGESNDGSDSETGIPDLESKSTRKDTSRKAFDKIFKQVVDAADVILYVLDARDPEGTRSCDVERQIMAANGGEKRLILILNKIDLVPATALKGWLDYLRRYFPTLPLRASGSAANAQTFDHKSLTVQGTSATLLKALKSFAHAKQLKRSVSVGVIGYPNVGKSSVINTLTGRLGGSQTACPTGAEAGVTTSLREVKLDKKLKLLDSPGIVFPCSNSQGDSKDDQARLILLSAVPPKQILDPVPAVALLIRRLSTSQALFSKLLHLYNLPPLVDTTATDLTTDFLVQVARKRGRLSKGGIPNIEAAAMAVIIDWRDGRIQGWVDPPAAVPPTASQGVKPATAAITTDDRKEIVKEWAEEFKLDGLWGEDWNEAGEGEEMGMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLA5</accession>
    <name>A0A2T6ZLA5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1088622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLA5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLA5"/>
    <dbReference type="OrthoDB" id="5413892at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="17707" checksum="BD96602E9AD6259B" modified="2018-07-18" version="1">MTNTNKTVAIAMTWTAGIDRTGIDNVKTITPTAEQLDQFISDLDDIIEDIAEINQNMALMDEDLVGLGEDIKQFSQTMARLNSYQLPRLNNTNAVDEDFVLTPLYGVNNNVIDSFPLTLRDLNALEDAGIDVLLQELGVPVAAGTELAAKKRMFRCYIGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLD7</accession>
    <name>A0A2T6ZLD7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1194891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000195">
        <property type="protein sequence ID" value="PUU76234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLD7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015780510" evidence="2">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="11726" checksum="E91FCF8012F4B3BA" modified="2018-07-18" version="1">MVYNYLRGRLVVPLLAVVVVVVVAAVVGREAGKGGSEEEEDDEDEAAGEEEVEDMIGLATGVSVVGVNAESSEPEGCGDFGEGKDGGVDEVFKRVEAEELITADVGLSSALPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLN6</accession>
    <name>A0A2T6ZLN6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1109491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLN6"/>
    <dbReference type="OrthoDB" id="5411734at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="528" mass="56259" checksum="AC926A14DA186465" modified="2018-07-18" version="1">MSGEGNESMLSSLDGPTPILCRKYASQPASPRDKSAMENSREGLSPPRSLVSVRSMPAILVEQGCLDGYSLEEYIHSLYASYVTPQKAKQSLLLRSPLIAVADSDLILSGREPILGTLIPSRKGGSQAVTESDTSSPPMPLMKDYYGSADEYTSASVSTKSVASEEVTVLDFARTSEPEGDRGFMGARGHLPRASPRVNPLGLGLSLNTDIEKDMNDPDPSFHRAAGSPRGPVREAFIEQVGSAFYFKKLKNDSLGKLPRITPVEWSFPEHESPELTAIQESSPGGGYRSRGPETPSSNSSNETIRPGVRNVVILPGESDRRYHSSCCRRSHGEMDIGSAAGIKIEEGEGIILHHARHRGAIAPGGPSCPPASPTTPAATTFSLLRKEKGSVVLERKPFPPGHGGSNYRGIHPAPPIKTTVLCYANVLPEQSRTPTPVLTIGDNDTSQPNSPSGSGEFSSVRWSRVSVASSMPYASGCTSGLEGSKSLRSIKALLLNEGIQLKEGDARSGNGTPGDRLSRGARLWGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN75</accession>
    <name>A0A2T6ZN75_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ppx/GppA phosphatase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1102131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN75"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN75"/>
    <dbReference type="OrthoDB" id="2014654at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="322"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="527" mass="57234" checksum="E214A229CD93C978" modified="2018-07-18" version="1">MADKTLLPVAGHATVPSKSNYRAAISLYDAQFSGTTKSPISKEVIGQILTSMRRFKSVCSDFGVLDQNVRVVATEATREAQNSAEFRDKITEASGWNVELLSKSEEARIGAEGVASSVGSVTGLVMDLGGGSTQLNWMRSEKGVCQMAEKPVSMPYGAAALTKRIETAIDGTAIGVLRDEMKEKISEAFNSLQVPKDLQLDAEAEGGFTMYLSGGGFRGFGYLLLDQHDIKPYPVPIINGFKAPGNAFSSLADLHLDPELSDRLDEKFRISGRRARQIPAVAFLINTLIETLPKIKTVIFCQGGVREGALFEKLPQEIRAQDPLPVATLPFAPKSTELASLLLNYALPRSAPYIIRFETAPALSNMLIYHSNVPKESRASCGLHSTTTGILASAHGLTHETRALLALSLCERWGGEVSDSDLKTRLQDLVGPELAYWARYLGAIARVVGNVYPAGIIGEEKLRFFATDEMANTGAIILKVAIREDDPATSAIMVMDSIKDLGKVGKKKKNREGFRRKVALNLVRDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZND1</accession>
    <name>A0A2T6ZND1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_205567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZND1"/>
    <dbReference type="OrthoDB" id="5451973at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="19170" checksum="DCB9D8B39B3D6019" modified="2018-07-18" version="1">MEFRSSYEQSLEVLCRIRSELMTRGGKYRALYPLLVKDDITRSRMQSAIRMGTGACVSSLLAQYQTSLFLGYKDQWRSILLEVRNQMMNRGNLSLRYGCEMINLVNQFMSETEAGDFPGRFCENIYNILGTMRRAKNSLNFYSASVISLYEELALSLVSKSFIFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNX2</accession>
    <name>A0A2T6ZNX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1086767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNX2"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015575368" evidence="2">
        <location>
            <begin position="21"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="453" mass="42830" checksum="2D1D4B0057592FE3" modified="2018-07-18" version="1">MKSTHFFLFLVSFTAVLVNGHMEMTDPVPLQAPKNPNTKTGDYDYTSPLAKDGSNFPCKGHIKAVGTPEGASVATWAAGSKQSFTIAGGAAHGGGSCQASLSQDGGKTWKVMSSIVGGCPVAGTPYPFTVPTEAKAGDSIFAWTWFNQIGNREMYMNCAAVTITGGGSGLSSYPDMFTANIGNGCTTTESTDVLFPNPGKDLVNNSKKTGPPVGNCAGGGGSSTGSGSGAGSGSGSGSGSSVGAGAGSGSGSSATLSAAPSMTSNASGSSGTGSSSAGSSGSGSSGSGSSGSGSSGSGSSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSSGSGSSSSGSGSGSGSGSGSGAGSQIVSSYTPSAPPTTVKKQASTTAISIPSSPAALKPTTTTSALVPIATPPIADNVSVTTTGVVSKIPYLTTAAPSFTSTSKGKCKCECNGRVFTIGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP29</accession>
    <name>A0A2T6ZP29_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP29"/>
    <dbReference type="OrthoDB" id="3595585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="17706" checksum="51777F747D04923C" modified="2018-07-18" version="1">MSFYAIPTFPEKSYGYLNCEQDVADGIKKLFRGVKVRVEDARPDTFVPRGIPHEEVKGEKDMRKHAKKDGVPTPALQITILRIIHPLEALYKPTTATPYSSAISPTNTSFCLGFSLGSSCDVNEDEDEDMLGDEDEHLSSPMTSMPPYLFTTETFIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPD9</accession>
    <name>A0A2T6ZPD9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1086446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPD9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPD9"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="623" mass="67290" checksum="ECE019F81FB9CF71" modified="2018-07-18" version="1">MPALSSGLPLYTSDTQILESVNAEKPANLRAHQGLNEVAFRELYEVDRTVEEIIAGGYTRVALQFPDELLRDSTRVYELVLEGINRETRQEPREGTAENEDKAGSGESGCNRDGNCATDTLPKPTHNGETGTAGASLNTKVCSCKTPSALKTTQPTTAATPTSEPKKAFILADTSYSACCIDEIAAEHCAADVLIHYGRSCLSPTTRLPVIYVFTSNPLDLNHAASTFSNKFSDKSQKVIIMADVTYSSHVAPLHKILQGIGYTNVYPTEVIHDPSARIPNRSLPPDCLVEGEEGEGEEGGLKSYSLFHISPPLPSLLLVLASRVHSIHTYDTTTTPPTCNQETTSILLRRRYALLSHARSANVIGILVNTLNVKNYLPVISMLKRQIRDAGRKSYLVVVGKVNVEKMANFAEVEVWVGVGCWEQGIVGGGEEGSGRGFFRGVVTPFEIGIALSEKDGWGWTGRWVSDFETLLKMDGGAKNATAANGKDANVGEEDGEEEEEVDGEEDEPPEFDLRTGRYVTTSRPMRRKSRPTKHSQDPSTSSSALIQTSNSSKQLSGAVGGVVSPAAQFLKDKRSWRGLGSDMAIEYEEDGSGNDGLGAVVEVGRSGVARGYTVGGEGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQU1</accession>
    <name>A0A2T6ZQU1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1101667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQU1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQU1"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="314"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="518" mass="56123" checksum="F9AAC55D80F2F815" modified="2018-07-18" version="1">MGQQPSKRSSEKGSAPPSSSTTSLSADGNTLPITKSDTQGSTRSIRGSIRSKISASTNKDSPSTSLATLPGAADKSDAASVRSSATPSLSRSVPNSEPSTSTNTPYDSTNSLVPPPSPVHGFVGKGHSAVEGGKNKEVDHVSDVPAGSGSMQPPHSQTPKESILIKRPGVPNPVTIGNGSAEGGSPGTDNMQMSALKSIDLDDMIMRLLDAGYAGKVTKAVCLKNAEITAICHAAREVFLSQPALVELSPPVKIVGDVHGQYTDLIRMFEMCGFPPNANYLFLGDYVDRGKQSLETILLLLCYKLKFPENFFLLRGNHESANVTRVYGFYDECKRRCNIKIWKTFIDTFNCLPIASIVAGKIFCVHGGLSPSLSHMDDIRQIARPTDVPDYGLLNDLLWSDPADMQTDWEENERGVSYCFGKKVILEFLARHDFDLVCRAHMVVEDGYEFFNDRTLVTVFSAPNYCGEFDNWGAVMSVSGELLCSFELLKPLDSAALKQQMKKGRGKRASLMYQSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR06</accession>
    <name>A0A2T6ZR06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1193709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR06"/>
    <dbReference type="OrthoDB" id="10667946at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015587814" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="19834" checksum="329901C0D0A67C65" modified="2018-07-18" version="1">MLFSKSTVIALLSVIAVTAEVPSPSIPDWIGVKSTGKTLLITDDFSLPGSSFTVGPTVSTPTVSTPTVSTPTDIQPTTTSGSTYVVIPDHTIQPPYFNSSAILTATTTASRGSPGNSKNLSKTVSIGESVTSFSIVPIVTANVTITKPIATTTPGNGTNRTTSAILTQPTSLGSAITPYGAAFLVVLVGFVAMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS12</accession>
    <name>A0A2T6ZS12_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1108389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS12"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS12"/>
    <dbReference type="OrthoDB" id="3595585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="471" mass="52223" checksum="6CB577784205EFBF" modified="2018-07-18" version="1">MIRNLRVDIDGPISPASKKCATDSPTHVEMEEETQHTYVSLPMVNTRAQAHDEEGKKHNRPGDTQIYQLEERENMGVVHLHITPLTPETTHSLLPPKVLAEKAVVASMSFHTIPSFPEKSYGYLDCEWGVADGIKKKLNESLFGGLKLRLRTPGLILSFLGAFSARRKKAKKCKEKGVVDGIELRDRKVQRGWSRPPAISTPAKRDGKRDCLFRISTTTPTPTAPTSTTTSTERTKEKRTDGTIKEFTHNTKFPQFLQRTSLDKDVSTTTATFDESLGWLNSTGAVIESALPLPPPPPPSNPTRRHNHYLSPLVSNSLPPFLPLTFHIHLNNRLRITIPRIVHRLEALYKPTTATPYSSAISPTNTSFRFGFSLGSSRDVNENEDEDMLSGDDEHPPDPMTSKPPHRYRSAAPTPDTAIGHRKFFPPDEDEVPDLSGGGGRLRVIGSISMRSGEAERRGSMNTEAPLLGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS13</accession>
    <name>A0A2T6ZS13_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ERCC4 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_983846</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS13"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS13"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="14">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU78278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="317" mass="35157" checksum="5AF32A7314BACD55" modified="2018-07-18" version="1">MPLADTPTGEQLQRFLLELGCRVNPTWAPSPSDNLKLVKWRRRVKADFDEDLGMFVLLENEQIRDENHILIYLTAEAFTNIALPATAGRLSAHVQKIKSAFPTPAMAKKPTRLIYLIEGLQALVRKHKNLQNRAFQNRVLSHLPSAPNALGASTALNTDDGTTINEDDVEDALLDLQITHNCLIHHTSSPVETAEWITIFTGDISTIPYKHSRTHLDTSFCTDVGQVKPGMGKRDTYRKMLQEITRVTPAISTAIAREYPDVRRLIGALERGGEDALVGIENSSTRNALQSTRTVGTACSRRIAGVFLGRDPWGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT24</accession>
    <name>A0A2T6ZT24_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000113">
        <property type="protein sequence ID" value="PUU78626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT24"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="19096" checksum="1AC124913994540E" modified="2018-07-18" version="1">MAMTAAPEFNNFVGEYVGSVKEADFTFIPRIGHRRQQSAAYPSVVLESGWHESSTRLLADSKLWQEGSAGAVRVVLQVKFYEPDNQNEMRLVLSISRTVPGGGPTQHDHYASPIFPAPPQRQDNPSISLDEFYAGACPPKIDPATAIPLDLELLREEAGFYIRKQGHIPADMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT53</accession>
    <name>A0A2T6ZT53_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_52888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000110">
        <property type="protein sequence ID" value="PUU78658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT53"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT53"/>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="394" mass="42054" checksum="664E6BCF83499824" modified="2018-07-18" version="1">MVDYRAPAYQFPHRKPTEPGAPPPLPTKNSLRINPNHSSRNSYGPPSASSSSSHIRRRTSSSGTLPTQEIQGMQTYTQNYHSSYIYPQNPHMNRRPSVASNSRGGAMDPAVPITIRRSGSTHTTNSASTSAQSAYVATLRRQKATVWCDRSQHEDPHLLAAHQRAKLRAAMEVVGSSNSAFLSAGHNHHGIGSATGSAASSISGGRTGKLGKTWVSSASPGIGGGSLPSGVPTRLSATEVLGDDDDDLYPGGAGIHKRSGSGKSSLNSNHRRTNRSSSMMSDTNRNCTIYGGVTGGLQHRNSRGSTPSYSSRSSIAEEGTPSTTTKTKPKSEKLPESPSESAPPRAHHVPTLQNPAILKRDNTLKRRGSLDEEEFVRTMTLSGNRLFVANPDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTK6</accession>
    <name>A0A2T6ZTK6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1101185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTK6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTK6"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF5">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="509" mass="57618" checksum="178ED255EB2C0A43" modified="2018-07-18" version="1">MSSRSSPPLRYNEIVCVGGGLAAISLGSQLQIQYNFTDFHIYEKNDGIGGTWWANTYPGAACDIPSALYSFSFAPNPDWTCSLPAQGEIKEYIDRVASKYGIPQRVSLSTAVTKAQWDEGRGRWRLSLQDLKTGDAYFHECKILFTAQGLLVEPNYPKIPGLETFKGHVYHSACWDHSVDLKGKKVAIIGSGCTATQIVPAIAPEVEVVKQFIRTPHWILPPPVIEYSDFDRWMYKNVPLAYRFHRLLVFASTEWSFRLFGLSRYSQGQRDRYLYEKAPEKYHELLLPDYQIACKRRILDGGYLTSLNRPNVQVHKEKAIEITPRGIKGSSGIHDVDVIVLATGFQTSGKFFKGMEVLGRNGVSADQHWDGIGGIGAYNTTAMHSFPNFFILLGPNSVTGHTSAIVAIENTVDYALRVLKPVLRGYASRVEVKERSEKEYVNWIQAELRKTVWNTGCTSWYTSNGWNAMTYPWSQLHYYYRSRVVKAKDWEVTVTPLPWPFGLHKLTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTL0</accession>
    <name>A0A2T6ZTL0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTL0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTL0"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="303" mass="34053" checksum="30CC527B368463CC" modified="2018-07-18" version="1">MITTIIAGSSSDIPPGSSTTDSQWFIQAAKAWSFLRAPLHIAYAVRTLTDPNISIITPATYPNWATDTGWWFHHTQPDIRAPIVACVNTMWTNTPLFADYPLITTPLPSYIELIANPQEVLNVFDVMAFKNKLLQNHGFLTLKSWLLEGDRKWAIERGSEGVQLVNGFVGMLDALDELLNVNIFVHLEELLEGRKTVTLVPDGQGNFMKLLIIQPVVQVSGMMPRSRHVLFTKNTRVLSYLTGAGHPGRDDQDSLWAMVAKGFGWEYLMFVRNCIETARHLHEARTPESPGKEVGSLDNFTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTW7</accession>
    <name>A0A2T6ZTW7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1064633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000103">
        <property type="protein sequence ID" value="PUU78938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTW7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTW7"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="35095" checksum="7AA8306145E91CBD" modified="2018-07-18" version="1">MSAPPPWYSIVPIPEFNTPIARYDFKNKELEQLLYASVVHERSFASSPEQRDTFEALTWVGSSVLRGLTTVLLASMFPTSRKKVLNDIRQALEDKAFYAHLSRRLGLHNHISLTYPAGESDHILSGLFTAYVGAIQRELGTDGFPTISGTFCQLLKPYAEAYKSHHDTYMTANPHLPPTPIISPVSTAPSSLAARQQQVYPILQTAPTSDSGAAKLRRQHVSVYTSRLMEYTAKCKLPQPSFIYKDNGCQGASIQWCATVSMSGTDIASAVASTKLEAKHLASRDALQAIGSSIHHWPVAGRRQKKLQVRRTTGGMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTZ5</accession>
    <name>A0A2T6ZTZ5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_980797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTZ5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="233" mass="26168" checksum="A7746F8A3D4D772D" modified="2018-07-18" version="1" fragment="single">LSPVINFFTSFLFGGNVTLYVGPKRKRMEIHKKLLASISTELNKHVNNDMKEGIEGIICLPDEGEEVLTLFTEWAYTGDYTRKDNTLPANTGKPKEPKHDPWPSLHKHLQLCAFADKFNVPILKQLAQSKFHTEISPVTIEPNYTRDVSGLVMVIGFAYDNLPSSDPVLKFLAQYAAWKLELLRETTSFNDLVLSQPDFLKELLRNVNGPGAKPTTLQKHTQQAATVFHGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU85</accession>
    <name>A0A2T6ZU85_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC3/GANP/Nin1/mts3/eIF-3 p25 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1047426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU85"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU85"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="359"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="546" mass="62789" checksum="D22995B4E5547F46" modified="2018-07-18" version="1">MSAPPWRSGGTNGNNRNGAFHSVNSRKTLSSRPIHHEGTQVHNDLFFSPSSNLFPLAFCRRTLWKKKILMCTNQTLTQTPAPEQTPKTQFPDKLKDYVARTFEDCPPDEKVAVELELKRIITDAFNEKVVWSLEWDKMPLPQTILARKKVTAKEEQTAKTLAMGQMSRVSNETGASPTSPFIRKPNYSNVMDVDYPGKKRKSAGSSEELTPPTPDRFEERFDKRPRQGDKFLPTSGKLSQREKDKRAKRFEDERREYSPDSATPEVPDNKKPLIGRCMDLEKRYFRLTSAPNPDHVRPLHVLEKTLEMLKRKWRSEANYSYICDQFKSLRQDLTVQHIKNDFVVTVYEIHARIALEKGDLGEYNQCQTQLHSLYREGFKGHEEEFKAYRILYLLHTCNRADMNELLANLTPADKEVKAIKHALEVRSVLAAGNFHRFFRLYLEAPAMGGYLMDSFVARERKAAMCMICKGYRPDIDIRFLTEELGFESDTDCVNFLYDNEAADLIEQKLGDKGVPNSIRFQTAKALPLFERAKKAAFSKVDIKGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUQ6</accession>
    <name>A0A2T6ZUQ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1125479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUQ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUQ6"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="283"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="512" mass="56555" checksum="7208C26A23AD35CD" modified="2018-07-18" version="1">MSALRHLSYVMGGGGDESAPDEETPHRHHHRHLHHHHHEKKDYSVAPTGGNVPVKIPSDEETQRHRHRHRRRRASTAPEDNVPRPLRVIDPDFEPKKKSRPHKRSSVSSNGTTSSDSSAASSGGIEIRGDRRSYGESPPLTPLIKTTPPTPSPLEQARRTNSQPVYRPLPPYPVTPHRDGAEYIAFSPVGNMSLPEGPQKRYSDSAVPRRFESHPGAVEIGSSDSIVQEPKRVDSSGSSASSPKSSTLRLDEKKASKPARRSGLANHRGSMRENQYDFLKTFDTVFVVDDSASMAGEYWDQLGRALENIATIATKYDSDGIDIHFLNSPQYDRKHITSPASVRDLFNRVQPAGITPTGACLDRILREYLDKYADAKAAYTPPSTTGPGPHPTIYDSLPKPLNILVLTDGEPTDDPEAVIVDAARKLDKLNAPLHQVGIQFVQIGNEEGAREALEELDDALEEIYGIRDMVDFTPFVGAPSAGEGEKLNGEMILKALLGAVNRRYDRWGNKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVC5</accession>
    <name>A0A2T6ZVC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVC5"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="43936" checksum="DA6FEA36C3C41BBA" modified="2018-07-18" version="1">MELPCTHDWHPECAVPDISFGHGPASCCQKLAALPAPIPPSPRGTSAPAAALKDSAPKPSLVHEALQKFHEFHFRRRAFDYEQALSIKMPLEDYIEFKKHLHGGGEESDKFPNYSYDTSRSLLFTEHMAGPLHEKLVSMIVKGLNITKSRLPSDIRTRIEVVRNQKFNGFKGLYEGSRKIPDLALQVANEEGDMEVKFVVEVGLTETYTKLVDDARLWLEGIETVSLVMLVKLEEAPIYQCPIRNLSQQRLAKINFPPSNQIAGHHFLLESRYGPAIFNGFTWVGKVSGFFEFWALDQSTKLATCMSSRNDISMMPNNLESGLSLSRLMDVDEKYDEEIFFNWEEYIHTIDRCIKETAAYRCREGLNDAKKRAGGLDTDYQPLSQASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVX1</accession>
    <name>A0A2T6ZVX1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_978851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000087">
        <property type="protein sequence ID" value="PUU79594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVX1"/>
    <dbReference type="OrthoDB" id="5356388at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="245" mass="26813" checksum="ED1DB205463253F9" modified="2018-07-18" version="1">MSPCVRYSGDPLTTVSATLDRSQGQSPHEPSPTQNPRQRDPASMVFINVTFAPTTPPQTPTDWTPQPLQTRVPGVEITAAHPTESPAKVAVKVGDSPSFFIATQEKPQNVKRAECPRCGSTFAGAQKLKRHQKSGACERQGAETSPEVREERDGVWKRSCPFCENSGTYKTRNSAVVAVRRHYKVRHPERDLGDKRRRRTNGRIPGREGEGGGGSDGGLMSADGGGEDEEYFIPPDGEDYGRIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXD5</accession>
    <name>A0A2T6ZXD5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">High-temperature-induced dauer-formation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXD5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXD5"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="895" mass="99812" checksum="BB434D991DB652AF" modified="2018-07-18" version="1">MGAGDSKLSFKKGVFRLAEEHNIPPHDPYWLSFWELPESAEDVFTLFAAADIRRTRDHHLENLETLILVVTSRLFTLKNHPSFPDPELAPEKHALNCIRILTRILPFLYEKDGLEDWGEKFFWGTRRKRSRKASLSRAQVIFDEAHPDEETQPPTAVEDIELAPPLMEELIDTLIDLLFYSGFTLMENPSSKGKVTYAIWQSGVGCNTPVGTTKELESNKIETLRLLLAITSKAMFIPANILPVRGTRALTYIATSADKKVVLLTLCSLLNTTLKYNPASWRVPYDHVVFSDPRQVLVTYCLQLLLVLLLYPVPEGRPDEPPLKNNYRHYLGRLHRTQDFQFLVDGMTRVLNQPIQATTSYLPGSQKTIQWAPEMLMLFWESLQCNKRFRRFIVETDRVHDFVILIIYYALEHRLDPSKSGVVRMCVFVLQTLSTEPKFGMSLNKHFEGQNTLPSSVRIPSFSGTYADYLIISIYSLITGSKGRLGAVYPALLAIIANVAPHIKPLSAAASTKLVQLFASMSAPAFLLANETNHALLHSLLESMNSIIEHNYSENTNFVYAILRAHKRFEALRNFTLESGQEEIDRQKRQKKDRGESQDSSAKNSMSQDDLASPVEERKPIAGSESPAPPSQFEIGDEEDSDEEGKSKSQPPASSVGTPTSARSPTLPSRTPSMSSSAEDAVPIQLRAMSEKARGKLPEGAFQRQASTTSLASHVSAPATVTSLNGFTPSPTWIESWLPHLPLHTILVLIQQLQPQLREVLARNHGEPNATSALECIRTTEVHGIEPSLVKTHMFEWSPLALGWYESLLWGFVFVAERHVSKGTVGVWNGTAVKLFRVQETAPEGPSLLAPRGGVDAIGSNLIERLGGASLGRGQRQRNSSDSVASGNRERHAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY41</accession>
    <name>A0A2T6ZY41_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_975224</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY41"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY41"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="4">
        <location>
            <begin position="94"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="420" mass="45475" checksum="693E8C2A57CAF01C" modified="2018-07-18" version="1">MSSAIFRSSSPLIQTIARQPSTAIAYQSLSVLSRPLAAGFLPKERTIQVFQQRKNISSSAPTLAPPRDQSIFSAPPGHGPHSGFFRKESLPANTIIRFVPQQTAWIVERMGKFHRILEPGLAILWPIIDKIKYVKSLKEAAIEIPSQSAITADNVTLEMDGVLYIRVIDAYKASYGVEDAEFAISQLAQTTMRSEIGQLTLDHVLKERAALNVNITHAINEASAEWGLVCLRYEIRDIHAPDPVLQAMHRMVSAERSKRAEILESEGQRQSAINVAEGKKQSVILASEAKKAEQINFAAGEAQAILMKADATARGIEAVAKAIKENKEAAQGAVSLSVAEKYVEAFGKLAKTSNTVVVPAQLGDLGGMIAGAMGIYGKVAETQASQQKMLGERLEGVKANRGNGAHAGKEVLDAFDISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY77</accession>
    <name>A0A2T6ZY77_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1079362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY77"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041014433" description="Hydrophobin" evidence="5">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="12392" checksum="D88C2109B0A1948B" modified="2018-07-18" version="1">MVSIKSLAVLLFAAAITAAPLAGDKKGGDSNDITVTKNSCEAEQKIHCCNDDGKSQNAGLVSLLNNAQIKCNNLGVNVLAVPTLTDNSMCKGTIVCCPGDNSQTGLVNANADLRCTAPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY84</accession>
    <name>A0A2T6ZY84_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1063470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY84"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY84"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="851" mass="95309" checksum="298FBB8060B90546" modified="2018-07-18" version="1">MDPLSQIPTTTVTENYKESRNSHIPNASRMMAIPIDNTHFTATYKESIIPTSESESEFQYHNWETGNLQPVTSRIQKLQTRLQDESVQRQRLEARISALENLIQEAGLQAKSQVLNPILVNQKRNSNMMLDSASDQSEEMETILNPHTCSSRETDHDVELAMHESPSTTASGHSIPTHTYIDKGKRPAYSVVARGPALVQARFKSTTIGMAQEIPTQSNVQSSRHHPTNPVGKNDSRNSASTPLYLAGVPKQAINIIKQELRSKPISVQGRHIQNVSWIDGRILELLVDSNHAESMKNRIVKYSNYTLRKSFDPLCAESFHCQGDIAPESKKAFLQRKLVMRLSESISSTKYNATRSHIMTWATNRAVGKQLTHELGKKNITILSERSEKEKTTSDIRVIQRGEVASSDNRTLVTSGAVRFTFPKRPYSSIDAIQDIYSGSSGSSSNGKFAQAISLLETSFDFLFIAEHWYQHHDKRLVHPLVHCSTIRPTSFTSRPNNGRQHGGIYLLATRQSQKIILSTTSTAHSIVVSLPGLKFAGVYYPPYSLNESALKADLNQIGSVDMLIGDINTRFSCNLIQRQTHSRVSPSARSLHFQSWAAMHSMIHLSDKPSHKTVDNIPDHAFSKLALQPFVSLALIPNSKLNINTDHRYLLQLDIDTTTSPLDSAIPNTPDLPPPLRFRVQKLRQPEIAKKYCSAWSLIDEIYTSYKDSEIFDIDMLDAVLCSSIQAIAELELGTYDPSKVRTTDDCTANHLTQEFDMPASIQLLKRSQRAATALSPLISLSDSLPPMQECINHYGTIFKKNLERAETTTGAYSGTRSSMPVFPDIDTSTQTEQQSYFAFIRPYLLNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A014</accession>
    <name>A0A2T7A014_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1168413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000051">
        <property type="protein sequence ID" value="PUU81087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A014"/>
    <dbReference type="STRING" id="42251.A0A2T7A014"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16831" checksum="1AA13FFF6E1D99FA" modified="2018-07-18" version="1">MPVKLIPRDPDVFAQLKTERPKPETESKPEAGSDPTKETDEPAKVTEDKEMVYKPKPVAEVKPPELENPEGVTHFLLNELVAIDAINNHLPPNAPKEDIASVPMHVHMEQGESMGKSAEVSREKLFSKLENPEFKAEQHPNSFTEVSACKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A040</accession>
    <name>A0A2T7A040_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A040"/>
    <dbReference type="OrthoDB" id="5475348at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="242" mass="26802" checksum="6C0389CDE1E3E6F9" modified="2018-07-18" version="1" fragment="single">MEVSRLKICLEEATDPARNPLPGNVYPILTSPESQSSSTQIAELKDALAEKSDFLKMEEQRSARLSDLLNQSIMEVNRLKICLEETTGTAGPPLPETSKQNQDTPPTSSEEKGQHHEKPHQGSNTLHGDPKQDSTQTHNEERSVNNTNGSEYFTEDENGSALSTATTQVQNEVPVILPISEGTLFKRRKSRGEPTTTTEDDNHGHFVIHTHQGSFTLSSLDEDDPHMKEEHKDLRPAPAPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0F8</accession>
    <name>A0A2T7A0F8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_972282</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0F8"/>
    <dbReference type="STRING" id="42251.A0A2T7A0F8"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="313"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="408"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU81232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="459" mass="50406" checksum="28005FF9DD4FBDEB" modified="2018-07-18" version="1">MLTEDQVPIDALIIDAGPLIRNDFTTSILSRVGKLYSTPAVIVEIRDAATRSRLETTWLPLLTLRAPKLESIKVVGDFAKKTGDFSVLSVTDLQLLALTYELEVELNGGNWRLKSVPGQKKVNGPVPKAMRENGEEKEEKEESGKDGDEKTEDGGDAETAVLEDTPAAPIEDCLSQKLGQTHISTNQTPITSTEPSGSTEEALSLPPEPTMNEDPNPTPGTNPTGNAPTPAFSSPAPSSTSTSEDSDSEGWITPSNLHKHQPKSTPSFPSSSTNSIKAFWPIRAALATTDFALQSVALQMNLHLLSTKTLQRIHTIRSHILRCHACFKLTRDMAKQFCPVCGGPTLQRVSCSTDSKGTFKIYLKRNYQWNNRGNVFSLPKPMHGSANGKGDREVLILREDQKEYEREVVKGERRKERDLLDPDYLPGILTGERRDAGGRPRIGYGRRNPNVARKGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0G5</accession>
    <name>A0A2T7A0G5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0G5"/>
    <dbReference type="OrthoDB" id="5496133at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="357" mass="40102" checksum="44D84818496E605C" modified="2018-07-18" version="1">MSSESRINESSIQNSQPQENHTAPLAASEQNRFHHFHREWVARTYGVQAISLPPQHFFQDPTYPSYLRNTGLTLLDTQYNNVQHEQQAANLYPNPILLPTNIEIRHRLPTAPICTTSTPIAGPSQLPQPNRAHQFADRPIPVTPKNRLTNEQKLVVVRHCIAAVEDYRRMGKTEFFAIQREIIKRTERFDCSVEVVMGDILIQAKVHKSACSGSRSGVAVAATDLDQAVVMWSEIVRKKEEMFAGDKGGEKDKQDNQETLSRLRLAMTQRLAERGEIGLVEGVDLPALSASMMELADHDASTGEGGNTEEEEGGDKEREKGKKKREWKERPGAGMSAGKRQRLAQEQDENLIYALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0G6</accession>
    <name>A0A2T7A0G6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_972310</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0G6"/>
    <dbReference type="STRING" id="42251.A0A2T7A0G6"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="155"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="358"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="502"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU81237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="546" mass="58610" checksum="584C65D72323D360" modified="2018-07-18" version="1">MAYDAYRGSGNSYGGGGGGYGGGGGGGYGGGSNGYSNGGAGGYGGGNSYGGGGYGGGGAGGDRMSNLGAGLKAQSWDMNSLPKFEKSFYKEAPTVASRTSAEIEAFRLEKQMRVQGRDVPKPVVDFDEAGFPSYVMNEVKAQGFAAPTAIQSQGWPMALSGRDVVGIAETGSGKTLTYCLPAIVHINAQPLLAPGDGPIVLVLAPTRELAVQIQQEVAKFGKSSRIRNTCVYGGVPKGPQVRDLSRGVEVLIATPGRLIDMLETNKTNLRRVTYLVLDEADRMLDMGFEPQIRKILGQIRPDRQTCMWSATWPKEVRQLASDFLNDFIQVNIGSMELSANHNIQQIVEVMNDYDKRDRLIKHLEKVMDDKNSKCLIFTGTKRTADDITRFLRQDGWPCLAIHGDKQQTERDWVLNEFKTGKSPIMVATDVASRGIDVRNITHVINFDYPNNSEDYVHRIGRTGRGGARGTAITFFTTNDAKQARDLLTVLREAKQQIPPELADMSRSGFGGGGGRYGSSRGRGGRGGGGGGGFTSSNSAPLGRSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0K2</accession>
    <name>A0A2T7A0K2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1077419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0K2"/>
    <dbReference type="STRING" id="42251.A0A2T7A0K2"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="4">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="219" mass="24157" checksum="40C43FB455D1C6C7" modified="2018-07-18" version="1">MGFFSIPSCPTCIRRLAGGALHQIRGKKRTRKIPTITVQLTKDVPRFGKQGTVLQIPRGRMRREWFPQGVADYVTRHMLKSMPAGTLKHRDPMFMNTGVQEKKPKVAIELLTPTQTIALLDSFIPPNLMFSRSTISPNEPAIHGSVTSTDIATAVRNIAVANGKQGSRIVVGPENIKFAGKGAEGDKLKSLGTFDFEISMKGANDFVRRKVMVVKQEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0M0</accession>
    <name>A0A2T7A0M0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_625672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0M0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="200" mass="22712" checksum="CFF1AA40295FC7C9" modified="2018-07-18" version="1">MGPGVEHEEEEEGEKAVKNTIPYALRHLLRAMTLASLLALAPCKHLDSTLPSGPSPFRPCVGSYCTRVLWRGSRTRPLLKAFQPTVAFLALALALPAVSTFTIFYSSTNGWLIPQSRSRSILISVRFTLWFITVRFFFIGRVRRTIPRSSKKETEGWKLQYDDGEEGRIIVMIIIIIIAIIQAYRKITRRTQPLSSPKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A100</accession>
    <name>A0A2T7A100_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_609971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A100"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="63" mass="7224" checksum="87C41F9F55065E13" modified="2018-07-18" version="1">MARSTRINLERLSKTIPTKQQVPTQSRRNPITYPPNQTLPLSFEPLRRSIYAASKKLCIEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A112</accession>
    <name>A0A2T7A112_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_914255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A112"/>
    <dbReference type="STRING" id="42251.A0A2T7A112"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="271" mass="29157" checksum="14E831A08BAB9FE2" modified="2018-07-18" version="1" fragment="single">SGNHLAPPPPSSIWRNLSRSPSPLGLIPIHRTFSSLIHKHEVPRKLLHVSIGFVVLYLYQTGHQPAHITPPLTAALIPIASADLLRFYSPSFNQLYIRLLGALMRESEVAGWNGVVWYLVGTITVLTVFPKDVATLSILLLSWCDTAASTFGRAWGRYTPRIRRGKSLAGSLASFVVGAITAAAFWGVIVPGTRPFLDDPVDGKMWAGRLGLQALGLGDTQVNGGWGLALMSVVTGVIASVSEAMDVFGLDDNVVIPVLSAISVWGVLRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1R1</accession>
    <name>A0A2T7A1R1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1165341</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1R1"/>
    <dbReference type="STRING" id="42251.A0A2T7A1R1"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="183"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="329"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="476"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="648"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="829"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="970"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123027" checksum="AB17A29BA69137EB" modified="2018-07-18" version="1">MAPATKKRRTEIEKEDEEAEAKATIGGLSSEEEAEAISKEDDVGGRTFEAKSKKRKTPQHPSSEQEKAQAVSESYESKSSVFRMETEELLSELRVDYRKRMAPVEKMLHRLKNIIDEIPRKTDATIDEVEGEMRERKIHIPFPEPRPGADIKYKFSYEKPAYMNIAGSYALKTVAKQHEGFAIDLILQMPPTIFQGKDYLNHRYFHKRAYYLATIARAVQDSELDLQLSYADLHDDPLRPIIVAAPSSGSETDFTASKCLIRIIPAVSKNTFSVSKLCPDRNAVRPLSERDTASCSLPPTPRYNSSILADTTYFEHLAQLHEASSEAKAFKDACLLGRTWLKQRGFSSNINQGGFGHAEWSILMSLLLKGGGSKGSSVLVKGYSNYQMFKAMLQFLATRDLITNPLLFDVESESVRWPNGPNVFDGKIGLNILFKMTEWGYRLLKHEAEITLKLLSDPVIDHFEEVFLYKLDDPCLKFDALAYIPISECLNKDNGPNPLLSFSQKLYDMLSTGLTDRAKLIHLTLPFTSAQSIRVGGINLSPAPTRQIIAGLLLDAAQCNRAVDHGPPAGHKDGASYRVFWGDKAELRRFKDGSILESVVWGTKDLKQSIPNQIIQYLVIKNFGDEIGSCVKFIGDEYASAVGGGGAGLFQPTMAAFEKLVEELRNLEGLPLAIRQVSPAAPALRYSSVEVPLFSSGQLMQPADVVVQFESSGRWPDDLIAIQKTKIAFLLKMSELLEKAGVVTRIGLENIDYPAMNSAFLEVVCCEGSAFRIRIYHDREQTLLERQLLNKDILGKKRDEITAALSEHRRRFIIGPLHAQEVQKLSHRFPALSPSIRLLKKWFQAHLLSREISEELAELMTIRTFVATSPPPNSVMSGFLRTLHFISLWDWRAEPAIIGTVAKSTLETFDAIRRSDPAMNRHVMVIPTEYDPTGTTFTEFGPRKVVAARVTALARSAVGASFKNMFISSTKDYDFVIHIDPKYTLPGIRSKGSKFKNLQKTGIAPQDIAKLGLNIPETFVNELNGIYGDTIIFFTDGNIIAGLWNPSSVSGRRWKVNIPYSTIPQTRGSDENVLVLNKKSILNEISRLGGEILAKIEIIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1S7</accession>
    <name>A0A2T7A1S7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1076712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1S7"/>
    <dbReference type="STRING" id="42251.A0A2T7A1S7"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="409" mass="45748" checksum="707267EDF1C8B035" modified="2018-07-18" version="1">MTSRYLLHFRPPSLKLSCPRTTPIPSRYFKSTVAYTPPQVWSKMSAPPPLSPLPPPPPNPLNTHPQRRPHNESPPRNQKRRRLPSSAKPVKEGGVEEVLQADVSSLLSTLGLSRPEIPFSEQGLPPRFSEVELTIKMLSSTGDGLAEHSGRIYVVPFSIPGDIVTAKVIRHMPTHSVTDFLSVKSPSQDRDDSLIGCRYFSTCSGCQFQMLPYAKQLEHKRNVIQKAYDNFSNLDPKLLPGVGDTVGSPLQYGYRTKLTPHFDGPRKGGFKAGDPTPDIGFMVKGQRRVLDIEDCPIGTEILRKGIKSARKYVEENLHTYKRGATILLRESTTRRPREESEGDTEWVEEKECITDSNAQTTEYIGNYKFVNPAGAFFQNNNSILPAVCSPELIVVVSFHQPTFILRLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1T4</accession>
    <name>A0A2T7A1T4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1076496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A1T4"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="421"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="964"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1210"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149181" checksum="1A662936CDE87459" modified="2018-07-18" version="1">MQFREPAKQANMSSRLEPPEIMLPGPHHPRKQRKRDIIFHIFTSGKRVEKPDPRRPRYVAPIHELGSQVFSIAGGISTPRGTWGSGDTKVGQEEAASVKISTVRKISLWEKAYETLPQEDRATFLGSSEHQNPVRVTLQNAKICQNKCYDKRWKFNWKGKELLLHDVVSRIMTWIEKFETIGDIVSQYDLSHAALPWTGFRSLLQAIVLVGVDGPMGIVLISLEKIGSLIDRCAIYEMLYLNSDLFSPDHLSSHNSEEISSVALEGSLVKLYTAIFRFLVQAKNICSQTTKARFAGAAFGNDDLWTLFDEIESLETDMCREAQVLEISYQTCFDDEKLAHFHRVLDFLANLTDTTTRFGAVVAGSHPKLEKTEKAAILQWTSTIPYDHHHQRISATRLDGTGEWLLERKEYGAWRSSSASMLLLLRGIPGAGKTRLTSKVVDSLLQSRHPSEGLAYFYFDRNEGSRRSCEVVMKTLVKQLALSPTNPDLLKPLVEIYEKRNVSGRLSDPLSSTESRNLIVEFSQLYKQTILVVDALDECDTNARRELLEALKYIITSSKNLVKIFVSSRSNDDTTRQLENFPNYHIEAKDNEGDIEKFVREKINYSVKEGKLLQGNVSPELKELIYTRLVGGANGMFQWVALQIENLCRLKTESEIKEKLGKLPSGLFKMYSETYRQINMQEGSSPDIAKMTFAWLMCSIQPLTPEELVSVIEFQLKAQGGGPPSPQLGTDVAVLLETCHNLIVHDTELNVLRFSHLSVREFLDTLDGFRKTNNCIMATTVCLSLLSNPDIQVGSENEHAPIARKNILRTGNPFFKYAALFWPTHIENCRELGVYSGEVKESLQTFLNPAKQHRWCYERWLKYASTSITSLVYTERRKLLLGAHIDDLKSQPNNPLVAAVSFGYSDIFRALFGLLDLEITSIETMLIVASCRGREVIIRMMLDYEGHFNKQHDQVPLEAAINARGGKALVEAARFGHEKVVALLLERGANINSRGGAALMRAVEKGHMEVIKLLLNKEADVNAHNGWALEKAARWGRQEVVKLLLDNGADVNIGKGDALLRAIENGQETIAKMLLKEKMDMRTIDGQTLALAAEGGHVEIFKSLLDSGMDIYQKDGEALVKAAGKGHVGIVEMLLDRGADACAEGGLALIRAAAGGHDQIVKMLLSEGAEVDKKSLQRALEEAARGGSEQSVEMLLGAGANARAWNGLKGNLAPLYNAALGGHEKMVMMLLDAGAEAYGLDLFDIVKQEKNLAIAQALLEAGADVNEDDGDTLRNAARANQRDMVEMLLQHGANPFFRARQIDQETSRPEYSEVKALIGEARKMWNGYRPPPSSSGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A240</accession>
    <name>A0A2T7A240_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1042468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A240"/>
    <dbReference type="STRING" id="42251.A0A2T7A240"/>
    <dbReference type="OrthoDB" id="5396653at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="630" mass="68914" checksum="4A0F66347DFC3303" modified="2018-07-18" version="1">MDHREPASIEFHSYQQSPFSPSASSILSSFSFQKLSETVFIILLNIVKMVWNTLFHPLPYYTAPTTPNSRLLTPLVYLYWAVICCVLLPLAPIYLFTSLVGTIYISTQMGWRLKQTKPEVVEDIKKRYLGSVTVTPVVEPTPVAEPTPVTESPSVAEPTPVAEPASVAEPTPVTEPAPVAGSPSVAEPTPVTEVAPIVFKAAQNVVSVEEVVEGKGRSEDDASIVPPAVAEEVEAEEIVPLAIEPTLTAEESLATPHEPTSIVHEEAQTETHEEIPQVLAKQESLTVREYASPVVEGPYLEDVGEISTAPLQKAREPIEETKGVYSCSMMESKSTTESAPSDYSESTSSDIEESDEDEFGESKHKEEQGLEGIMEEEEEADEEILRKDLDEREVSDQELTPQAPEYSEYSPSIPQTKPEEPAFVPAPRVYGPPAFGICEKRGIREIFDPRERHSLRAWMRQPVSVSVEESLASSDESSLYDDESERDGSPPISPISSIGGASNGRGIIGNLELDIGVEKAESVEDDVDTPVIPAPLAPQKTETPQVTEEVPPCVALVEPIPTAIEPEKKATIVDEQKLIPVAGIAPKLERSNTDDSGFESGSVKEVKVQKKKKKTPMKQRLGNKKSKRNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A294</accession>
    <name>A0A2T7A294_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A294"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="206" mass="22425" checksum="F0EFB583103F0FFF" modified="2018-07-18" version="1">MAPVPAASSNFNVVISSQPSSTYSCSVFYSNLNPPPTTDPVEAATVQTADWEAPSIAPAPLTPSQLPLSTELEQKPLVPETETLLEISDPEATDEFVEFVSQSQRWDNHRKRPVQDQGRPATAMDRAPVGEYRSSHFQEFLMAVSIHLIAIFLSAAITLAINRIARKLCCGPASSGGCELWKYQLWSISGPSVSSKFGKLLFEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2G4</accession>
    <name>A0A2T7A2G4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_970048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2G4"/>
    <dbReference type="STRING" id="42251.A0A2T7A2G4"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10917" checksum="D6E2C249A5A86FC4" modified="2018-07-18" version="1">MPTPSLNLQIPSYLDAYLLDARVYLPTCYTAPVTQHWDRKLAIIGHPYAPLGGSHDDRVVLEVVKTLLRAGWVVSTFNFRYDLKNKKNKDTLDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2J0</accession>
    <name>A0A2T7A2J0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1075880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2J0"/>
    <dbReference type="STRING" id="42251.A0A2T7A2J0"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="269" mass="30305" checksum="25A024CD1AF2F640" modified="2018-07-18" version="1">MNFVHLPSELQLHIAEKLESRELSCLSRTNHHFNSLCTPALERLAQEPRGLLCALWWAILHNYPPLVQLLLSKGNDINHLDGKLYFGTALHVSAMVGNHPLITLFLNNPALDVNKLDMDGETALHKAIAKHNLEAVKLLHAGGVDLEIANRFGKTALFLALKYEHEERTVLMEDEEIMENEEIIEFLVRNGANLNVLLSTGTEPYITFLQGLVWVGNERLVKLALEYGADPEVRDRWHNRAIDYAVELGLTGIVDILREVSLPLDMDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2M6</accession>
    <name>A0A2T7A2M6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1075944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FYV7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2M6"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013730">
        <property type="entry name" value="Fyv7/TAP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08524">
        <property type="entry name" value="rRNA_processing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="212" mass="24171" checksum="F9AFEDB2AEDA54B7" modified="2018-07-18" version="1">MGKPPLPDKPRKKAFRIGPANLPDGTYKRKVEKIKKSLIHKAKVKKSFAKTISGDAPDTDPHAIRAKRLLEEAATEREQAKSAEHKDGEDGNTIAATTEMHPERRAVLDQPEMTRVEKDPKNVDKGAWRKREKKRKTPTFLKEEREAARLREAQEEKERQIRARKVAMDKSKKERALRKKVMSARTTKGQQKLGRQSALLLEKVKAQVGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3F5</accession>
    <name>A0A2T7A3F5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1121024</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3F5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3F5"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="144"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="466"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="642"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="643"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU82258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="699" mass="76724" checksum="B65AA7419DBCE51A" modified="2018-07-18" version="1">MAKRKAEGASPPQSPTKKGKPAGSIPTDFKPFFREGLFDEAVQGKYRSEYATAEPYKHAVIHGLIDDALLRNVRQEVLKNVEFAPKETDIYRIHQSGDLANLDGLPKSALKLLPSLRQLRDSLYSKLFRDYVCGITGCGPLSGKKTDMAINVYTPGSHLLTHDDVIGSRRVSYILYLTSPDGPWQPSWGGALRLYPTKVAEDGVTRIPEPEWTKTIPPAWNQLSFFEVQPGLSFHDVEEVYAPEEEGGDERIRMAISGWFHIPQEGEEGYIEGLEEELAEKSSLQQLQSKSDIFDYPKPLEFKNGHEPDGEEQDGDEEGGIALTEKDLDFLLNFIAPTYLTPDTLESLSDAFAEDSSVQIAQFLSKSFAKKLKEFVKARDAKQYSPGDSEGWKIALPPHKHRYLYLQKPPAKSGINLEELNPIEQLLTVLLPSKSFAKLLHLATGLKITAGGFLARRFRRGLDYTLATGVGGDGDDDGEGEDGEGEDSSPGAGLKVEICLGITPSKGWGGEDDEDDDEEEEKAKNGKSKGKGKAKVPRPSKFDDSEKTVGGYEMYMAGDSDSDSDEEDDPDQAFKSNGKRKKADPAIYRAGRGNEDDGILFTMPASWNRLGIVLRDTGVLRFVKYISKSAAGDRWDVIGEWGVGDDGENDEAEEWLGIQDADDDDDDAEVEGADEEAEDGVDENEKQNGSDSASGSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3L9</accession>
    <name>A0A2T7A3L9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_968230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3L9"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="757" mass="82440" checksum="D2C654B48E29E44B" modified="2018-07-18" version="1">MLAPSIETSDYDTASIFSGAASLFFDSRPGTRIGDFSHSRRRPSTSANMTAPKRQVRRSLSVSNILPRNGPQKHGRGGKGLSAEEEGSDGLVGLYSADLDVSRRFSEPLVDSPYLLLPRPASLSMSGEERDPLPPIQSLSALELDMEALPATNTNNNNDLDDCRLETLSPVDPNYEADTDDDGEEVESEPFSRGGGHHQHRLSVISASERASTLVGSEDLGHFEGDDFQSETVFDSVRTRVSELTPVRLDAIFRLPPPEPSEYHLPMGSTKSYMSSDFTPTKANDVLPSSSTPTILTPHFQRSNMSDDDDDGSSSDWDIPSKSTDDAGELRVPTSSGLRPLSGIHLSSRLGLNLNNASNTSFGTALEGLSVDSSSIRETSSILEWSESIPSNGTPPSLSRRSKTIHPKESLLSGNRVGRRVPGFHIRSQSVPVVSDVRAVPSPSENWDDDFLDDDGEEGFEFARREMVIPREIEERQASVIGHLGCVREFALLVEDLKRLRDIGNACGLRNGAKKHLLEEADGIIALATLDDEDTLPSVQPERGHNRSSWHTPSRHSEMTLDDDFKSTPRNRRRSSILLPDDDVFGGGKLPTTPSSFPHLRHGFRSPSASSSPSPLSKKSIDKNDPVEVAKGIMERMQLQHWQGSDHPIGSGKSKGAWNGGKVQFDTDMLRELVIHVGGLKRDLAELVDCLDSPSLKKHPHYITSDVVESPTALETGEYGLDISPGVGSFDQESCGSGLEKVRSNNGVDFRPIVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Y4</accession>
    <name>A0A2T7A3Y4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1099158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Y4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Y4"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="352"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU82434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="637" mass="70320" checksum="CE56D968CD4678C9" modified="2018-07-18" version="1">MNGNTLNFPSFQSSSINAPIGRPVATPQNAPHKFVNHKRRAAEVLISSPNRHGAGHQGAALMVRISMGLKSGIPSEVDYALSQLVRISFDSGDELRAEAYPGLSEALFEKLATIQSLANTCYPEGAGELLEDSKFVKQLEKINEAALVLRNMSLQPDNARYFSRLKSGRQIIVACMNLPGQSCFIELKHYILDMVEAMAIHFSLAVDDDLFPTLHANLLSDDRGLVLGSLRAICRLVMGRDEANCIGQINKLAIDRIKALIMLEDEDLVSACLDFLYQYTTNEENVEKLIQPPDGIEIVKQLTRLLLHQAVPGDQVVYLTGSLKPIIKPTVIPNLPQEIVNDLLSYAEPDRAAKWMRCCFEEDKTADITQIALWQAYQARFTEYVAAGRPLLPAAEFIKNVSVAFNNASAMVLPIPGGGQKFIIKGIKPRETPMSVKGQVYLACKWATATNSNNTASTETTQGQQQPAQPTKCPAQLATPQDLWVHILKDHLSPPDSTQQPQAKLLCNWGGCERFHPAGDSDRRKVIAHVRTHMPEPSPPKNSNPSSRQNDWLDDPKQIKLVIRRNQTGVDDRGEAAGIPLTAVLVLRNVARRGMFNGKELLSGERPVLFEIMAVNKPLSNYISDLLVEEDEGVTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A491</accession>
    <name>A0A2T7A491_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_389217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A491"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015501671" evidence="2">
        <location>
            <begin position="29"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="16092" checksum="A52F6CD0BAD27E39" modified="2018-07-18" version="1">MRPYRPWVHALVHKYSLALACIVTSVKAVFPPQPTFQGSSPVISFCSQLAFDHPSLRHASDMLAILLFLLFWLVPNFVFKSCQRAQFLFFFKAWCLDEGGGPCVPESTDSLIPLYRTNIDSRSSSSFNTFCGWWWCVEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4E6</accession>
    <name>A0A2T7A4E6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1074396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4E6"/>
    <dbReference type="STRING" id="42251.A0A2T7A4E6"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="33231" checksum="315213DE456B67C0" modified="2018-07-18" version="1">MSFSRSALRNTHFYDATNPEVVLGGFRQNGSITEANFLSFLDILLVTQGGTVRVQARISGHIVTRTNVPLETGAYDIYCDGRIKITKEPSVHRLFSCSVSGKETRFRDEIRDRDRKCVISGTVNDELGIQASDWVSFEAAHLFPLHGESIWIDLDYGRWITDMGDSPPSWKIDSAQNGFLLRSHVHQKFDQYLISVNPDDGYKVVVFNCDIDILDGRILDPVCRDPANPHCVSDHLLRWHFRQSVLANMRGLGEPVFEHDFPPGTDIMDEILEGPYGKERFELEMAARLRGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4G1</accession>
    <name>A0A2T7A4G1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1154365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4G1"/>
    <dbReference type="STRING" id="42251.A0A2T7A4G1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="346" mass="37462" checksum="736ADB6E538DAABB" modified="2018-07-18" version="1">MGVLLSEPVVDKTSESGEDNRLAYGISSMQGWRVTMEDAHAAVLDLQNPDDPTKAGSEGRISFFGVYDGHSGDMVANFSGENLHKIMAKQPADGLLSTDKAILQDPQYRDDVSGCTASTALITDTKIHVANAGDSRTVLSVTGRAKPLSFDHKPYNEGEKARICAAGGSVDSGRIVTAFPDVVIHAVSDDDEFLVIACDGIWDCKSSQAVIEFVRRGIAARQELHTICENMMDHCLAPSSDTYRGSSGNMTMIVVALLKNMMTKEEWYDLIAKRVADGDILGEFDIRITNNSVRSIGGAGHITMLDDGSEASTDSEDGEAFDVEEEERDLPLLPMQFSQIDRSSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A529</accession>
    <name>A0A2T7A529_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1074058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A529"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="286" mass="31353" checksum="00900C418A04C06A" modified="2018-07-18" version="1" fragment="single">MGSCDFMGISGRSNTLTPEPLLHLTLRLNSGLLRNPCAGPGFQKLGIDPDTGLLPLLHLSFSLSHCCNLTPQPLNSLLSRTSHSRPLLRARSNSELILRMLFRRLDNAQAPALGALRCLARSPGPRDFHNFTSGSDFSMHDSRGCRVFLNFQAFRRCAMGYLRSQNLSPSRSRCGNGGSSYNAILFLLILLQLCLHPHFHFHFHFHFLLLLLLLPLLDRLTEPDQGAPEYAKAVGEHAIETGFGGFNGFGLRLGGHVWPCGDSSGVIFGDGVIGGLGLHSGWLMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5K2</accession>
    <name>A0A2T7A5K2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1189953</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5K2"/>
    <dbReference type="STRING" id="42251.A0A2T7A5K2"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001100">
        <property type="entry name" value="PRK00133.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="258"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="677"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="190"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="806"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="858" mass="94643" checksum="D71A5EA99BDC6CF1" modified="2018-07-18" version="1">MASLKVNIPIPAPSGSSAFTQTLKVCLAASAYGVPVQFAQVSGQTNISLEVPRENKILIEANAIVRYFATTGSRPWLKSGEVALKDSALIEFEESGQGIKAADVAESVISKANFPTDPALPPSPAEIILFSNLWDLASTSTSDDRPTLSSWLIRIIGTEPTLSSWLIKIIGTEWAKVGVEQATAHTADKPVTKSTGKGVGKGVGKGVGKGAGKGAGKNTSIPVDDTPREMIQKIKEGTNMKIRDPKEPILPVPGERNVLITSALPYVNNVPHLGNIVGSVLSADAFSRYAKARNYNTLYICGTDEYGTATETKALEEGVTPRALCDKYNALHAGVYKWFDIGFDYFGRTTTDAQTEIAQDIFLKLQKNGFLVEKTMTQLFCEKHQGFLADRFVEGTCPKCDYEDARGDQCDTCGSLLDPLDLINPRCKLDGTGPIKRDSKHIFIQLDELQSEIEEWSKKTSEEGQWTKNGRIITESWLKTGLKPRCITRDLTWGTPVPVPGFENKVMYVWFDACIGYVSITANYTKEWEKWWKNKNEVKLYQFMGKDNVPFHTVVFPGTQIGTRENWTMLHHISTTEYLQYEGGKFSKSRGVGVFGNNAQDTGIPPDIWRYYLLSSRPETSDTQFVWQDFATKNNSELLANLGNFVNRLIKFVNAKYAGVVPDYTAGINDLSFNQYKEAVNALLKSYVEELEEVHIRAGLEKAMAISGEGNRFLQDNKLDSALFTNSPEKAAAVVGFGLNLIYLLSALIYPYMPATSESIVKQLNAPPRSIPDVWDADGLLPGHVIGRAEYLFSRIEENQVQEWKSRYGGKQEAAPRDTKKEKKKGKSAARQQNAKEGAASLGPAPTSTANVEVRLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5N1</accession>
    <name>A0A2T7A5N1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CENP-Q, a CENPA-CAD centromere complex subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5N1"/>
    <dbReference type="STRING" id="42251.A0A2T7A5N1"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="361" mass="40183" checksum="A877E132D0222F71" modified="2018-07-18" version="1">MAANKPKQKQKATRSSAAAGGGARRRSSNITPANSRTRRSIQTTTNTADATANPGTMAKAKAAPPAPTSTSASSNMLPPPRPLVTAKVAGTKRKLITQEAEVEAERIKEKKDESRPAKMPMLKPRVRNVPQEVVEAKWGVLSDKGREEVMEVVRAAERPVLMTFRRENRRAEAQEVLHRVVRKIGNSLTKVPVPPLGKDTYLNYEKLLSKNRALEAILEPDLRQIAGLEAEIEREQKLLEKEEDYLQELKKNAIAQENIRRQKSRNMHPILRNAPSKQDPIDSVEKINLTSKLSATSLYDVNSDRQLHPLTTQLQQHLTSMQGNSGSLGEVTEWIQKGKAVVDEVLFRKAGEQVYDSIMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6D7</accession>
    <name>A0A2T7A6D7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_161771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6D7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16543" checksum="79C039C868A25DC7" modified="2018-07-18" version="1">MRRRKSSAKRSTVSTPRPITAPRALYLLSSILIDCHGAMKSSIRDRIASSNTELCISMHCDLHCLPHTFSYLLIVSSPHRCEGFSLPSFQRYREAETTSSSRIQKGCEGFRGSMVCAFIPGPIHQGSCYGGTNSVMKPSISLLVGAHPSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A729</accession>
    <name>A0A2T7A729_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1060970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A729"/>
    <dbReference type="OrthoDB" id="5352648at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015469134" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24049" checksum="7EEAE2DED01613C3" modified="2018-07-18" version="1">MFSATSFIVFLAALLTISVSARRIPQGQEIVPVPPFHSASYPYSTNDCDEACRRAFCTAVSQFLESVTCTSHRPCLSLNIQLHVQEKCINWHPETTHSRTSISKDSSGISLTPPPPPRDGEEGMEAPSPLARPPKTWIRPVSGSPVVDSVILGDEYEQEELRMTARKTLCFMGVLATCFFGWCGRVLRRRERRNRLGSDNRRPAWANSIPEKCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A730</accession>
    <name>A0A2T7A730_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1072055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A730"/>
    <dbReference type="STRING" id="42251.A0A2T7A730"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015612650" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="186" mass="19806" checksum="DC4DE1F6E217D63A" modified="2018-07-18" version="1">MKSTIFSSAIAIFATLATAAPTAAPSDIVARDEVKQVILSSAVVNIQEDAANTPLGVTYKAIVSRVNGKHNSQALVKFDFPDGLTGYKCKLDFAYPAQFSGTGEIQVFSIGDTNIENATFNKRPFRDQFKGTFRVAGWGEAVVLDASGLTFDCPAKGAKAYEVVSQGDSNDVEWYAPGGGLRIDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A736</accession>
    <name>A0A2T7A736_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_15193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000010">
        <property type="protein sequence ID" value="PUU83539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A736"/>
    <dbReference type="STRING" id="42251.A0A2T7A736"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9074" checksum="3457A7AC39F298C6" modified="2018-07-18" version="1">MLTKILPSHLHVTAIGIGSALGAGGSTVFPIAAGEIANSRGITTIPPLLLGMFAAELVLLCWLPGLPAKTPGRQASLEEIISLQFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7U8</accession>
    <name>A0A2T7A7U8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_890291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A7U8"/>
    <dbReference type="OrthoDB" id="5423371at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050163">
        <property type="entry name" value="Apolipoprotein_A1/A4/E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976">
        <property type="entry name" value="APOLIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18976:SF34">
        <property type="entry name" value="LIPID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="663"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1239"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1329" mass="146158" checksum="C6E7B8F04E83B79F" modified="2018-07-18" version="1" fragment="single">MSATIPSSALATTKDFKDFKEFKDLKDLKDFKDYSLPPLPRDRDGGQSDWESRSRDRERDDGPKLSHQELETITSQLSGLTSIANSLQREMTNLSRRSKDNATDLISLKEATKSRDEDIRQSLRDLVHGLHSLESDRLLTNSSLPLITSGASTSSRASSYASDNFTTPAGARGEKSGLEMAALERVLREMSTKDEQDRVIDLLRDIQDTLNKPQLDRLENEEKILSLLEEFKERDYTKGKELVIPGRERDSDMDEKILSMLQNIRETLYQGQERENDVRIISLLEELKQMEEKGENAQVVSLLEEFRDREGGSKIDAVLSSLEELRDGGGDERVLSLLEGIKARIDSVKEDLTNSLSSSIARRSPSAQDATGTESTRDAVENDEILNALNHIKRGVDSGEETTRDVQKLIGEWKERWAGHDREAHEALKDLMKEIEILVTEQRQAISRLNSNPGLQSTALTMTNPPLPPDLDNEAAITALANIASTTTRTDITLSTINALIKVFHKDMNSANTHTHETVLSVSRFLQELGDTVSNTYSQTGETRKLLEVVRSGVSSGNDRLAEFESATLRKIEELMFLHKHLQKTMLTNGDEMIWKQDVGVRAVVEEFQSEVEELLEKNMEAVKESAEKAVEAINNSNPVSLIEELKSELGAMAQRSLAAFAAADSKEALAELKSELQRATEQSIEAINTLNPGTSIETFRAEVKELLEKILSASESNSKGLAKFEESAPAQAAIEDLKCSLEELIERSFNTSNEQASAAITDMKSVITDRTEDTEKIQTSIDQLKVEVTELIEKSATALVPPTSYPEAESIKARIESLALEITKTMDNTIALFSDSSVETDEKLKKAVDELKAELGEVSKSISEAVSPNSPSGLEGVVKEALEEMKEVVEQIEKNVGVERSVVYSPEVSEKITSAIEDLRKEVHEMVEKSISMAVGTPQTGESAYKIQEVIEGLRTDIASIMEKSSVADSFSDSFKELLEDLRKEVAGILEKSTSMIVPQSGLDGTTKELLGEIKKDITSILAKSPPPEAGAGNVKEAIEGLRKEVGELMDKTMSMVAPRPIDVEGLPPRSAEGMEGVLEDLKSEIGEMVQHSLAAAIANSTFDSEESVKEAIEELKRDVRDTLQLSMMPLPAENTEGAERIRAVLQGFKTELGELFETKIAVPNVTVMEVIDSLRAQIGVLAENSKGSAVTEIMEELKVKVEGLEQKGSDGSVVEESIEGLRKGMDVLMGKMDVSSSAEIASAVDELKREVEQLSGKSGDALEALKFQVQGLDIKETIEALKAQVEGLSGISGVPVPSGLSSTSNEEMKESMESLKRDIEEVMEKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A810</accession>
    <name>A0A2T7A810_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_962186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A810"/>
    <dbReference type="STRING" id="42251.A0A2T7A810"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="194"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="349" mass="38631" checksum="C5B544B0DD9A982F" modified="2018-07-18" version="1">MFFFTISLNKTVRFCDPATHRALARRVFLPRYRLAPQNPFPAAIIDALISYLYLLYPPPGALHSPVPASKIIIAGDSAGGGLAFALLQVLLHLNRKPGPAPKDEDEGFSRVSSQENFSISWRSSQRSIPLPGGIVGLSAWVDVSRCLGEIRLPNGNRGSEEECLEWDYLPTPAEQREGKYLPSPAWPENPGRTHLYAPDELINHPLVSPIGAESWYGSPPIWMCVGDECLRDANLFLAHRLLASNVCVRFLKYTSMPHCFQLTIPHLEVSRKSIANVGEFIEAIFTDGSVKVGQTRVGPKGDPKGEVPDDELSLGGLKLEDVAALMKNEIKLWKEQAQKEKEIKESGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8E7</accession>
    <name>A0A2T7A8E7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8E7"/>
    <dbReference type="OrthoDB" id="5407790at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="589" mass="63119" checksum="142BF00C1BA4E359" modified="2018-07-18" version="1">MRGEHQESASPIPQSGAESQDGAPPRVVKKKSSLRSTFACFFKSPRNKKANKTGSQYLSRKGEASAKNRGNEALTFSTISLPTRVRSSTSSTSSPYDDEDEEFNSSIPHAEHGASRKTRSTISLPAQIRPPFAFHAPSSSSSSASSLEFVSDVSTAATSPSASSPSVLIQSSSPPSTLAPNHSTTSLSSNPSRETSPTRTQSSTKPSKMSKRALENYRKHPSPLSTVTDAHSPYILPTTPEPPVLHERPNSFQPKRKSSLSNYILRRTQSHPDLTDFTTDDLPAFPQLPVSAPTSRPGSAASSRTLSIRRRSGKADIGAPTSYSTQEKIEHRSILGADPAGSGFYLYPPAQSEISSRRGGSHNGSSGSRSGSRGRAPMGGNMNDDPRRNNSWTGPDGHNARGMPPPGRGWRDPRGGRSFGRSVTQQVILEEAGDVADSPQTMSSSSSAPNLDSRQAVLGSGGLPNQSRSPDMSKNASLPEKDEPRRSLHNNWDSIQSQMQIHSDGFPQLQVPSEIKKEGRDWGIGESMALKKLQQGEMRFMDASSADGNSSRGTPVTIQFGHPNRLSAVGKGRGLIDSLPVVRIESVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8N3</accession>
    <name>A0A2T7A8N3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1060494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8N3"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="285" mass="33204" checksum="F35F8085FBFAEC19" modified="2018-07-18" version="1">MFRMLCSSRFQSSYRLALRPLGRHISTITTSNQNISMMAHKRENGGVQSETPKDKQGSNKSMPKIEDKLETRPWPESYKELQRLDDWWLKHSQEQEQELQRKSAEIQRKSTEIQNLKSTLMREKAERGRVERLIRIHGAIEKIITHAKLENLAEWVANHEVATIQLTSNPQFTKVLHEEVQARRLVLEDVATCVHEIYFRLLSPWRCRDKTVVISETDFTAEEYAALITFMKVQSKWQYPLSWREDVSGEACEEDTEGRQQVSCVPRPVTAISPHYSLIDQSHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8V1</accession>
    <name>A0A2T7A8V1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_961325</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8V1"/>
    <dbReference type="STRING" id="42251.A0A2T7A8V1"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000009">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="76"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="21496" checksum="D90FA788C22086EA" modified="2018-07-18" version="1">MRQLITGARGLCSANANFASRIPKYTVYITIPHPLPLQPQFNVPSKLMGSYFSTSTTNKITNEMSANTNSPVQKSDDEWRAILSPEQFRVLRTGGTERANSGTYNHHTSTGVYTCAGCNAPLYKSTSKFDSGCGWPAFFEGVPGAINRREDGSLGMSRTEITCANCGGHLGHVFKGEGYGGAADERHCVNSVSLTFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9G3</accession>
    <name>A0A2T6Z9G3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1013250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000793">
        <property type="protein sequence ID" value="PUU72128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9G3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="79" mass="8806" checksum="272C15FB17B97B61" modified="2018-07-18" version="1" fragment="single">VALRGHWFHLKQETGSGVMFGNLTVSFGKSQIGSAAIPIRAACCQGRPHILWNPVRRRVYTWSDCLLGELAGWSPWNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA01</accession>
    <name>A0A2T6ZA01_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1097541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000586">
        <property type="protein sequence ID" value="PUU72299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA01"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015768896" evidence="1">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="97" mass="9745" checksum="0216E2F6285FF8C4" modified="2018-07-18" version="1">MRASSILAKLIMLASIFGIVAAQGAPWTDTMAFTIIGTGVIPTTCTAGGQCGSGDLGRTISNIPITSCSSCLTIIPPTGTPVPISGTKTTMKVPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-05-29" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA73</accession>
    <name>A0A2T6ZA73_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1097370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000552">
        <property type="protein sequence ID" value="PUU72385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA73"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="8641" checksum="E396DCA507E41927" modified="2018-07-18" version="1">MLGVRREFKITVDYVNSFFFPRILHFLYNILYVRFPSLFLFHSHRSCPFPFQLGAINPYSSFSHYFVAPGGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAF1</accession>
    <name>A0A2T6ZAF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000529">
        <property type="protein sequence ID" value="PUU72477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAF1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAF1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="18309" checksum="442821C3488AE801" modified="2018-07-18" version="1">MELQMKTQPVLRNELRKQFLAWMLSTMTLAMEWELIRLPVTVYSPSLGRILRLFSPLEIFQIFRRRLGEPESDPTKHGLMHPGELVMARRRLPIHRITFGESTIIAESPTGPGFRRSNTFRFIVSALKRNPRERTGEKMKDFWRNVRDHLKDHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAR0</accession>
    <name>A0A2T6ZAR0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1104336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000506">
        <property type="protein sequence ID" value="PUU72563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAR0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAR0"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43613" checksum="FC314966446C885D" modified="2018-07-18" version="1">MSEERSRRPPPNAGRVRKRSREQMQAGPSSGSSGSSVATSTTATTTTIAGSGLILPGNVLGYPSQQRPSPANRNGVPQSSSSQTVIDLTDSPPPLPRSERSSHHPPLNLGRTEVIDVDALPDSPPPQIPPISPFGQAEWVGHQYDDEVALYAAHSLLSVGNQNRLFLNPHRRISPPRPVEPNALYSQVGPDAPFQRRFYPQADDPRLGHGGMVGPGPSGRSAMGGYNPMGSNYPPPRGVMEMLHSVRGAVPRAISNLHLPVRNRPAGIDRGFQPPGQLDYSRRAPGIIREDSPVIEDAARARNIDYKAPPPAREGFTRSPRDNDILVCPECQTELGAESTDETREQVWASKCGHCYCGKCVHSFRVPALTKNGKKGARPKQKLCVVCSKVNLAAKSNMFKIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBD9</accession>
    <name>A0A2T6ZBD9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1136844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000474">
        <property type="protein sequence ID" value="PUU72734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBD9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBD9"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="109" mass="12399" checksum="905BFDB9E429C8C4" modified="2018-07-18" version="1">MLKDEDLVSASLDFLYQYTTNEENVDKFIQLPDGIEIVKRLTRLLLHQAVSGDQVVFLTGSLKPIIKTTVIPNLPEEIVNYLLGYVEPDRAAKWMRCCFEEVPTADIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBG1</accession>
    <name>A0A2T6ZBG1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GMC oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1136584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000457">
        <property type="protein sequence ID" value="PUU72830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBG1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBG1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="534"/>
            <end position="535"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="603" mass="65359" checksum="C242469A7A21E64F" modified="2018-07-18" version="1">MSFPSEVDVIICGGGAAGSVVAGRLAMADPSLSILVVEGGKNNHNVREVVRPALFLTHLAPTSTTAKFYKGKASEQLNGREPIVPVANILGGGSSINFMMYTRASRSDYDDWKTEGWTAEDLIPLLKKTETHHLENKDPAIHGFEGPLHVSHGGHESDTTEQLLEAAKSMGYKITEDLQDLNESNAFEKWGKWINPETGRRSDAPHGFIHPQIAKGCNLHLLCDTKVVRVIIENGKAVGVEVVPAEAPTGSSAPLTIIKAKKLVVVSSGALGTPQILERSGIGAPEVLKAAGIKQVVDLPGVGTNYQDHNLIIPAYHVAPETITHDDFRRGSADVLEQGEKDFADGKGIYATNFINAGGKVRPTEKEVEEMGPEFQKFYDEYYRDAPDKPVMFICIGNSFLGNHNLVPPGKYVTIATYLEYPASRGTIHVTSPSPYEEPDFDPGYLTHEADIGPNVWGYKLGRELIRRTPCYRGELPAVHPKFDPTSAARAREIDVGEALEPAQTGGDIENLVYTEEDNRAIEEWVRETLATTWHSIGTCAMKPREEGGVVDSKLDVYGVEGLKLADLSICPGNVGANTYSTALVVGEKAAVLIGEYLGLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBY1</accession>
    <name>A0A2T6ZBY1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1096065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000429">
        <property type="protein sequence ID" value="PUU73001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBY1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBY1"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="579" mass="61554" checksum="5C3CDB6875448278" modified="2018-07-18" version="1">MTEPDQIVPSLARKSAFGDHARRVKKAFLTKEGLIGSYDYAFLFRPRIPFMRRPRRSAPFFGLDDRMPVLLALLLGFQHALAMLAGIVSPPILLGGAGGANLSAEAQRYLVSTALIVCGILSTIQITRFHIWGTPYYVGTGLISVVGTSFAIIPVALGALDQMYANGKGPMGKDNIRLPCPEGYGAILGTGCVCALLEIALSFMPPRFLKKIFPPLVTGPTVMLVGVKLIASGFKNWAGGNGPCSAMPKTGPYSLCPSTAGPHALPWGSAEFIGLGFSVFFAIIVCERFGSPIMQSTSIIIGLLFGCIIAAATGYFSKASIDQAPAVSFIWVQTFKLSIYGPLVLPTLAVYIILACEAIGDISATCDVSKLDVEGKMFDSRIQGGLLADGINGLLASLATITPMSTYAQNNGVIALTRCANRRAGYACCFFLIIMGIFSKFAASLVAIPSAVLGGMTTFLFCSVAVSGMRITATMPFTRRNRFILTAALALGYGATLVPNWFDYFFTYKGGGGLQGLLDAINLIMETGFAITAFIAMFLNLILPEEVEESDEEVPIESSNNSNAQELGSESLGRGAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC39</accession>
    <name>A0A2T6ZC39_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1006654</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:endosome membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="term" value="P:endosomal transport"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein PAN1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="DUF1720"/>
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        <property type="entry name" value="EF_hand_dom"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EFh"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="EH"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
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    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="112"/>
            <end position="147"/>
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            <begin position="365"/>
            <end position="454"/>
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            <begin position="398"/>
            <end position="433"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
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            <begin position="1"/>
            <end position="67"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="1352" mass="146920" checksum="1C4B8A14E4244FB2" modified="2018-07-18" version="1">MPMQYQATGQPGGLQGYPSQQGIPPVPQLPTGLSSFSPQSQQTFSPPPQQQQQQQPQQHKKTKSQAKIPTIRLSFITAADQAKFEQLFKAAVGEGQALSGDKARDILLRSQLSPTDLHQIWQLADTTKSGQLLFPEFALAMYLCNVKRGGKNLPSTLPEVIRNEVSSMVDIISFGVPDSAPLPAPRTNIPSFEVSSAPSQTPQTPISPPQPTGQPQPSNSQLLGMMAQPTGFQPQQTGGQGLQTQQTGFPGMQPQFTGFQPQQTGIAPQATGYGQGPGGYGGSIPPVPPIPTGVSSLMPGGMNPLQAQPTGRPGQWGFVNTPASVLQGIDALQERMMPQPGREGGFSTQGLQGNAVIPWSITKVEKQKYDQVFEGWDGLKRGLISGDTAIEVFGQSGLPKDGLMQIWTLADSGNKGSLNKDEFAVAMHLIFRKLNGYEIPTRLPPELIPPSTKKFSESLSTVKSFLQEGRKASALQPQITGVSYLKSRSFHDTTTVQERKDGTVYRFDDNQVGYKSSARHRARGARSPSPAVGGSPSPSPGPEMTLDQLRKKVREKQILLNAIDIKDEGEAENDDILDRRDRRDADDLYRRIRRVQDDIDANPNAAVGGIDPETERRQLRRQLQNLADRLPDLASKVRKTERSIADAKLSLFRLRDAKAYPGSASVIIGTGPGGAITESDRIKARSKVMMQQRLAALTGKPTVSTGDDDEAASRRLAEETQKIKSDQESNDRMTRDVEDSLTEFQKSLEDSLKFAPSESDGISDSERRRWEEALGVEDEVKEFIFDLQRQSHSAKLRREDDRDYRRRDERSGSSVQKPVEEPPRQTASPALAPPSRTATPSGSSYSSFKSAEERAAFIKQQAEQKMAERLAALGLKPPARSNIGETAQQRAERERKEREERLRKAEEEEAMREHNLQQRLADEQPKPPSPITSKKPPPPAPRRAKDDNQAKARAEEQARKAEESLRAAEEQALKQEQEAQRAKIEQKEEESRAEEEALLREQEAARARLQALEDKVKQGKLQKQEEKKKRQAALQATKEKEARLAAMRAEIEKAREEEERLKRLQRELEDSSSDEEGPEELGGVTPTKESVSEEQFVPAPSPSSTAASPPPPPPPPPPPPAPPIPPTIKAPSPPATAVPSVVSPTSVGADTNNPSNNPFLKHLGANGDVPVLSPAISASAVSTTPSAPSSSGAVPSKNPFYKLNPDQTAEPSPRITRRQPEEDDWSVVDDDESSSDDDDDPPNRQDTRALAEMLFSTMAPPRPLSSMGNKGTEQPISPSAGGAPPPPPPPPPPPPPPPPPMPSGSSAAPAAAPPISVNVGSLLSEISLGRTLRKTETKDRSAPASGGRVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC99</accession>
    <name>A0A2T6ZC99_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015463263" evidence="1">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15756" checksum="E52C50D7581E4352" modified="2018-07-18" version="1">MKYSVSVIILCFSAVLNVAASTPDDNPDPGQDWQTFTISFDAYRPTIGPGTNTFDQVKNRNLNIRVNYPLGYQYTIYKSDYTVYALLELGVTLKQTSSYWFAGFVSDKPTFQSYMGHTMATTPSPILFRAHSGRHAALPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCE3</accession>
    <name>A0A2T6ZCE3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1058439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000408">
        <property type="protein sequence ID" value="PUU73160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCE3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCE3"/>
    <dbReference type="OrthoDB" id="5360505at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="397" mass="44323" checksum="3257330331177CEB" modified="2018-07-18" version="1">MSAPEVSASSRTPFSTPANNLLWIPPPQDMPIAAAAPPRPELTLSAADYTKLQTYITTTTALPQSYEAYKTLYPDVLSPLTANNLYSRTGQTLVSTAALTKSYQLSFSEISDIAGAFIGFATQARLWYPRLQTQLLGLDATPGEARQGREWEGMKSAAIMALKTLSDLAEKKEGRIGAILAQFTSLRTETLSLKTAIQGITEELSNLQDNITREFADRSVKLQTLRVQRDLVEEERSQRNRERNRALLGLGYMFKDPLFGLLSTAATVSNIHTQYESKRRERNNLDNEIGAVHDCMATLEKAKVTTDSLEHTLVGILSVVDAFLEVCRPIKDTFRTMQTNFDHVSASLHATCNSTTGDGFLWAIEDLQKAYEVWERIAECAYEFQSEEFLKVCVRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCF4</accession>
    <name>A0A2T6ZCF4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1035461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000407">
        <property type="protein sequence ID" value="PUU73175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCF4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCF4"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="17436" checksum="09FAF5E1F7BD240A" modified="2018-07-18" version="1">MSEETHAPITGGCLCGAIHYKISFPAGPESEWPPVPHICHCTQCRKNTGSLMVHFFTIEPKTVTWSSPAPTFREYSASPGCFRGFCDKCGTLLTWRREGSLNEIEITTGSLDESVLEEFGDILAKPVGGQYWCRNFIKGLTDVVPEGDRYAEGPGSAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCM2</accession>
    <name>A0A2T6ZCM2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1095532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000397">
        <property type="protein sequence ID" value="PUU73245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCM2"/>
    <dbReference type="OrthoDB" id="5381061at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="559" mass="61069" checksum="62708E0198820497" modified="2018-07-18" version="1">MPLLKCDNSANYTNSPSRPRKYNHNNRHNHDHRRRMPDLISTVALVIALIALLVSGVQLTQQLLATGYTIRKCDRIISGNLTKGGKRHWHWRQFRFTVTYEGLAFCLPLELYASLNVSPAVSVSPEMTTGLWERAIKLRSERKADQGCWVSFVQDMAPYILAENLGRKWESGDRVPDDLTVAPVQVDVITVVLLCIAAGMKFSRYSPATGEISMSGKVGAITSAVHPVLGGLLHYTPSVLAVPNESLEEIRMHSRAVNQGKGVWANAVFGKFNDRGVGRGFLDFTMLLRAKQGILPRYGWPEDSYTDSIGGAAGFMALATVDVYVAIPPTCIHAWCAHFAEVIVKAHLYEIQGTKPVIHPPEFRHVRGNIIEIHGASSPHIPWDQLHHTHHTNPTPETLNTPIECLQPLNLANQDLLSCGTGIDGTKDPSTFVTPAAAWEVIMSADAASHALEKEVPGIRNYSNRVVAASIAPLAEVGAPSWGRASNVVTAWPQTVAEACLATSKSEGFPPHQEKLIFAHAKLSMLRASYVTIMLRAAGSIGPGLEQDSEPVTGLAYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCT0</accession>
    <name>A0A2T6ZCT0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000390">
        <property type="protein sequence ID" value="PUU73298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCT0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCT0"/>
    <dbReference type="OrthoDB" id="5507699at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="18712" checksum="582532B117B985D0" modified="2018-07-18" version="1">MWHSSGVATVLKRRITSSDLHPRDSLLGNWPPLPVALNQISNQVTNDAGVPLDLEYADTKLSDNALARSGGVLRMLPERRPITKFEGEHIRASTGESFTSGEMSDSSDEDETSSAEDSAGPNPSGAISMRRTSMSLLAAAEGEQKAMSARYSVCSLLPSISITPLGSVPGATSPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD04</accession>
    <name>A0A2T6ZD04_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1095098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000381">
        <property type="protein sequence ID" value="PUU73377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD04"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD04"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="292" mass="33251" checksum="6F8CEDE625432E04" modified="2018-07-18" version="1">MQPANRAGGRDTFIYDSNHRDTLLGGLWVAEGITNANLYCMVGIICIFTDTFDIHDNNEQLVKRDEKPLQPGNYFIVSNGSITLTEEAPLLRALSLHSGPRIASFRDAVRERDRRCVITGLPVLRPDHWGWGFFEVAHIFPLAYEDHWDKFNYSHWITVPPAIESDGSIHSVQNGILLTRNMHALFDGYGVSINPDDNYKIVCFAPEATYENIAGRHLDQIFLDNPLRPTDQLLRWHFRQAVLVNVKGLGEPYMEHDFSGSDIMTEIMTGPKAEERMEYELFSRFNATGLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDF2</accession>
    <name>A0A2T6ZDF2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1117335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000370">
        <property type="protein sequence ID" value="PUU73528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDF2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDF2"/>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="607" mass="69325" checksum="CB69A3A8A2A0F0B0" modified="2018-07-18" version="1">MALPPLDPRDPRDLRDRPWKRRSSSVSAPYFRLPRRSRRATYICWTVVVFVLYFVLNSATQWSHVPDPRSFYSRGSDIPVRYSHLYASLSKITGGGNRIWNRNILFAAGNLDAASKLAGIACEMSMYGRSNVHFALIGDGDMDIELFRKLNGITEENTDCKANFHDARADFASLMSVERRKLVVRTALRHLRDFMHPQALIMSAEHEDSWFSATITDMAKKLQVPTIELPWDAADSLRWITRLDSGSLSAWHKPSFEIVVHADKHSGNLERLLKSLESASYPTPRHRPKSLTVILNPSVPLHPFTKSFLSSYSFPSPSRTFIRRPLTAPKNPLESAKQYIESFYPDSDDTSVLVLDSNAEISKWYYHYLLFATLEYKYSSYQYHDTASLFGVSLEEPPSYLNGSSPFSVPAPPKGSQPSPFLYPVPNTRAALFFPKYWSEFHAYFSKKLLYPHKSSASENDTEPVPFPLSDTAADSWVVPILDIIRARGYVMLYPAFAYESLAIVHHEQPSYTRSPRKGKKKAVEEKPLMEKNNLLDSLPNGDLPVYNSKLPLIDWWGRPALWDWLEVDALYYRKYISNCKVEDVGLPWMVHNVNDIFCDPDGNSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDS6</accession>
    <name>A0A2T6ZDS6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URM1</name>
        <name evidence="7" type="ORF">B9Z19DRAFT_1094636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000357">
        <property type="protein sequence ID" value="PUU73651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDS6"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="modified residue" description="1-thioglycine" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="13213" checksum="E92E7012D8D7AE69" modified="2018-07-18" version="1">MGEQQDPSADEVGCKLISLNIEFSGGLEMLFSNQRSHRIQIPVKDSSEQPANVGFLVRHLCENLMKDKRKDLFVLEDRIRPGILVLINDADWELEGEEEYLIQDGDTILFVSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDS9</accession>
    <name>A0A2T6ZDS9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Wings apart-like protein regulation of heterochromatin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_521092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000357">
        <property type="protein sequence ID" value="PUU73643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDS9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDS9"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="593"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1069" mass="117809" checksum="5DBC849A9A400290" modified="2018-07-18" version="1">MEDAQQRRRPPAVTYGKPIKKRFSDAPGIFTALDHGSKFPEASNEVQSKAAAATSIPKTTTIIPLSPATPIRVTKAQQQQEKKKGKEKIAESVLVANPTQQKKGSSGMNGKSTFAKAYLRNITPPAHSPEELAAKKLDSVDIFDFEVSSDAEEVPVIPMRKGGRGLKESKQKPAITRPTIIAGFDAPSTESNIPEKNTTVSRKRSYKKGGGVTVPEPKRRKSLKDSDEEMGISVAGDKGKGAVSTTLPKGKQDFKGDKITSTAKVTKNSTVFKVTKHSTFEVSIPYTFGRQPLSKPVFSRSIVKSEAQFLTKKQGQEKKLKPLAKPKSAPALVEKKSAPHEKVEKPPPKSTVEKGPATKSGKTTLKTVTASRVQKAAPTVLPSLKVKHASPEPPTLAREKSAPLNISAPVDKRVRKRGKTKAGPRGTKQFSQEFSDDDEFDIPLIAELRPVRRRRLIDTLGGDARGSRAGTRSTSVTTDSSDDSDSFTQDAQYPQSQQLSESQNGTSQLQDLFQFGSQGQKQPALMPTYNTGRIGPKVTYAQQRSFKADENMSEQSLFGIPLMMMPSPYSGKKSLGFDEGLEEEPLATTKGMMKNIHELREAGSNNRFLDDVEDFFGDIEGKNVPLGTKRSGYIGLACKMVDKTFVRNFRANNFDTRLLKRVAKQTDEVICFALAFMIARLLREDSTVQILSEIHTNGTLDMLVRMLDFERDIKMVSKDKKTNMSKAAQEMAMDLRALVDKSAVFPQSKPTVYSAQIMGLMVLETVIRSLRAAGIHDRIVSLDVLSKLVAMVKAFITPAKVGKALDMLVLELLLSILEAWACGLDVEIETAFSMDELTTLTDIIPTTMAQAVTGDDGKFHVGDFDVKDILLLTLRLNINITNDKTEACDALANSDLIPILIELIRSRFGILDSQLEEVPRLVNLDLLVLGLGLLNNFAEMSIPGRCSVLRRDETGVLLLDILVKLFLARFAKAEDADSLEESQSNVGFGYLAILLGNLCQDTEIRIATRNQLPNKSLNILYESMEIFIAHHRKVDELKDESDIFYQLGEAHCAFTERLERVVRRLKEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDU6</accession>
    <name>A0A2T6ZDU6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor eIF 4e-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1068790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDU6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDU6"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="807" mass="86739" checksum="75FCDB4D8D332160" modified="2018-07-18" version="1">MDTPPVTTPPTSVILPGSPDHLATLEGSRNDVGSASGVPSPTVEPADMLATPEEKTDVANDTHDCAAVELPDSIVNSEHTENEPDKAENRGSNDKSESPVCAPEVSIMVLVGEDPALQATCDAVKPSAANWVHDLDPPDDRVDNVNHKSSVVKLRDSLVEPEDNVKEGDEVGGFASTIQPADRDFKAEISESENKLLTNNSSTDKSDSTGASQEDSAVGPGDRLGVKGCGRAEKCDDSERSSISRIVDYLFAIGTSITGASHAASEDNHDVSTDDHVFPIVTQQISPSFAESPIILGTTDDEVHQAEVDTSTTTCKGPLSTASEICGNGTGDKSNASSSVQPIHGIVTPGPIKEGSSDPSNEFPTGQSADNSVVPEIVEHKKTPDNTNGEPFTVVSTNVLAIPESSGMPVDSSDGYSTDRAGLEPVKDDEDRRLLAASPDSLAPSSTISSQAKDSQELEDELEEREICEDTIIDSTDRAGLDTAKDGEDRRLLAASPDPLTHSSNISSQVEDSQGLEDELEEGEICEDTIIDSTVRAGLNTAKDDEDRRLLAASPDPLTHSSTISSQAGDSQGLEDELEEGEIREDTITVFHDAVRFNVKHPLINKWTLWYTKPSSGKHGENWSDLLKEIQTFDSVEEFWAIYVHGPSPQVYPSLTPILTPYKEQCSPPSALANKSDYQLFKFGIRPEWEDPANKRGGRFSFTFHKGSNIDTQWLDVLLVTIGETLEPEGVSEVQGVVANIRKGFTRISCWTRTTGLGRTDRDRLMALGRHFKVTLGLTNGENLDFSEHDESAYVGSSARARASFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDZ8</accession>
    <name>A0A2T6ZDZ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000351">
        <property type="protein sequence ID" value="PUU73713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDZ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDZ8"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF3">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="312" mass="33974" checksum="9FCB5460F84A180E" modified="2018-07-18" version="1">MVKVFILGASGFIGFAIALALRRNGHRVYGLVRDSVKGLNLAKHEITPVIGDILRPSSWTFVIECEGIDVVIDSSNVHQNMSKVLTEAKRLGEARLKGLKRGPKLGFILLSGSWVHGDQPDARDIVNELTAPTPVEMVAWRSAVENELLSSSDVLDAVVIRPTMLYGGSGSIFSMLLAPIAAAVKGGASEARVLGRKIELPVIHKDDVADFTLKVVEKISYVGALSYPVFDITAQHESYTDIIEAAAKHMGFTGAIIYRDPEGPLATLEHAILTQFNTSSDRARTYLGWEPRHRDIMGQIDVYTASIVANQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEK4</accession>
    <name>A0A2T6ZEK4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Filamentation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1094123</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in endocytosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YPP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000336">
        <property type="protein sequence ID" value="PUU73876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEK4"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051722">
        <property type="entry name" value="Endocytosis_PI4K-reg_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083:SF464">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT DOMAIN 7, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23083">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN, TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1213" mass="131137" checksum="035E1D3F295FD12A" modified="2018-07-18" version="1">MSTVKANNYLQLLDTARCSGAWESVPELCRKVQKHAPGRRCLALASATEARLYLLRRSSSGSTPASTADKSTLLNLQESLLQELESCPPSLPNVPSPAGGGQVGVITLEDVLQARTVLAWIYSLRGEWGSALKVVPSEEELLGEWNGGVGKAEYFGVARIKALVLRGIALAHLKPDDPSLALQLYRAATRLPSTYPSSGRDSPSLLLWTEKALSHHALAAYCCWLEAHASQDPSRNHYTPTPDGDTEQPEAGLGNGSQVRTAIGKMVVNEATVAATFRGFHNFVAGIAQSQQATLGPPPAVEKGLTPEKEMERREVYRNYHKFLSLLLLPDGHPNKPTPRDLRQSTPGEGGTISIVSHNEPIGGVGAKAGTREQLKKELEAIGGVYEEYLLRGLAFPGAAEYHNIIGEWVDRVIENWLVSGGSGEDASAVVETLYKACTKSFHSPRILRHLFTALTATGNFPDALLALKTYVELIHKAKERISKGHVEKDFDDDKTILQTAVEGIRLVCIVTGDGEKAMTMAETLEKWIDEWDTRDPEVLSDVYRGIGMANATWARQTIDAERRPDAQLAAIKAFKKGLSYDTLDVDGWYGLALVQVEHGDIEPAVESSKRGLSCLKHLAADDEADEFWDGRGPYRRRAIPLLHLLAILMTVEEDFKAAERACENAFEILGDNMAVFRGMGVGEKEGVLEVKMTQIAIEEALNGPEAAVGMSANLLDLYGRLFEVTNVVGADLPTSTFQSVPAGSAPSTRPSTASRKSRLLGGRSHKKEFAASATNLSQDKSSFQQSGSDGNSSLTKRPKSGHQSLHQPTGTPNPNAPKIQITEHSSTRSANASKKQNRPKSVSGGTIRRMKSFGSLHSSGHSAKQAPEVPTPPLPSSTEASSVSAERSPVGSVKGHEHHHHPHLFHMLKMKLQKHQLQEMGSSNSSVVAAGQFAGSSTSFVPDGIRTPVDGTADGTADAVLDRSGLPRANDIPNNLEQSKLPHPISAVGSRITDELRGKGAEPRNTKRPASLPEPMLKEEDERKRAAGALRAVWIFVGGLYRRAGYLQDAAMAVEEAAGLVGTKGDGEADMLTQKALLALVEGKTELSAEFFDEALFVDVSHPLATVGLTNILLDISIEPNPSTLTVKEGALETTQKSEGDTLTVRNRAMGLLQQLTNSPRGWNVPEAWFALAKSYELAGELERAKSALWKCVTLEDCRGVRSWSSIRPRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFF7</accession>
    <name>A0A2T6ZFF7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1159636</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFF7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFF7"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015401107" description="WSC domain-containing protein" evidence="8">
        <location>
            <begin position="28"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="916"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1039"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1150" mass="121435" checksum="E0E1CFA335BCC98D" modified="2018-07-18" version="1">MLGFLRTRRGNWPLLLVFFMFASLCVGAPTDSVRDADQAQSGYLDNHNMDPAIVQGPTFGRVFPLSGEQFPPAAGSKQVVFAASETNWVYVMDAVTGAILRSKQVATPFLVSDIGCNDISSFIGITGTPIIDPATDTVYFYAKSYPGADRGVYNGAYWIHALDINNLNERSGFPKKVDGSVADNDPTRYFHGGTHLQRTALSMINNIVYAGFGGHCDKYNFTGWVLGVDKTTADIRAVFATESGAFAPPQDGTFVGGGGGAGIWMSGMSLSSDSPSRLFFVTGNGEGHQNKEIPASGRTPLGTLDEAIVNIKIDPATGKLSLQDYFEPYEYISMDAGDRDLGSGGIALLDPNTFSGTNAARLGVTVGKNGKGYVVNLDNLGGFKMGPAGSDAVVQTLQVPGGASIFGGSGSYPLEGGYIYMTPVGYPTLVYKFGKDANGRAAFTQVAQTDESSAGRVGVGVPTITTFKGQAGTAILWIADVDGGLRAYRAVPENGKMIRIQLPPTPSVTKFQRPSFGDGRLYLSTSNGYIQCLGSPVALPLNCTSPISFGDLTIGSKRVLQVNCTALIAITKIDGITLSNPLFTASNSSLPTGALAKGQSFSFPITFDLTNATIIDIPGTSIPSVKPGITSGALNIMTTNGVDKFATLQPIVVSGNLVSSLPFLAISPGEADFGGIVIGSAAAETGVPGSMVVQNVGSTDMRITGYAWALDGFEDGDPQWTNVTENSATNRTVGPSFYAIDLPAVDSIVGPGQSITINLNFKPYAVGNYHSLFQIWSDGGAQYILLTGAATIEPKAVLEVSTAEGGWTTGDFIDFGPQLAGVSLVRRIRLRNTGGSALTITKSKPPEGAELTATNPTGELSEGLKIPPEGSAIGNSINGTWTLNTDDLTFGVHNVLVQGVILSRQLGPLLPDGTSRYKYLGCYKDAVAGRLLDKNNNLGVNNENGICQQTCLGQGYIFAGTDMSQYHQECWCGNRVPNKIYFYEESANKCTWTCNADQSQACGGDGASSTSSTSTTSSTSTSAQPTYTGPPRYITQYNNYTLRGCWTEATQGRALKSKSLSIANMTVDRCWGMCNQYQFFGLEYSKECYCGDVLQPGSQNSTSGALCNLKCGGNSTIYCGGSARLNLYQFNATLQNSSSVLVGFNLPLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFV5</accession>
    <name>A0A2T6ZFV5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1000850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000305">
        <property type="protein sequence ID" value="PUU74352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFV5"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="661"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1026" mass="110875" checksum="30A79FED5BD484C2" modified="2018-07-18" version="1" fragment="single">SMARKARQRISYVLPLANSPGGHRLGVNSLAVDKQGILFSAGRDGAICSWKIGVDLADGAANSATLPRPAPPPSTFCTRAQAHTHWVNDLALCHSNAALVSASSDLTVKLWRPHAADQLPPDKIGVHSDYVKCLATPDEHSDWVASGGLDRKIKIWDLNGGGEKLQIDVGDEGNNPKGSIYSLGIGGGIIASGGPESVVRVWDPRSGQRITKFVGHTDNVRSILISQQGNIILTASSDTTIKMWSLTAGRCIHTLSMHNDSVWSLYSSHPNLDIFHSSDRSGLAAKTDVRGVAEIEEGICVAVCQDQEGVNKVVACGDYLWTATQSSSINRWLDVDTNIDIGPDLRRPRLTSSASTKPRGVNSPPPPGTPSSPTTVGPKQSTIPVNALLRLSTTSAFPSNVRDPDAVTVYSIPNARQASISETILDADPGVLVPVNDLPDETIEGQHGLIKHFLLNDRRRVLTLDTAGEVMMWDLLKCMPVKSFGKRHLEDVAAETNTVESVANWCQIDTRTGRLACVLEENYCFDAEMYADEADIEDAVEFKDDQRINLGKWVLRYLFSNLINEEIARDEDYRKKLDSDREEREQTRRANAPPQISMPPATFSSSEVGTQSPGGAGAATPKAYNGFSLFPQTPGMAIGLATPALALGPTNIAHAGEAAPLPTTNEEESGPRASLSPTTRGSIDKPSTCDYFSTGNSATPNKPISSGPSLGEAVDDAPTTPSTADKEKEEKDSSLLGRWRSFGTRKLGRSASTDMTNKPTVSTVDEKPSEDESVISDKPDPSEDTLLGVLRKIRGSYGIQVRERVGEPIRSSIAPSLPLETPVLKPPGNTTIIIQEDRLDFGGVADLYRGTVSSAGEDADLLEKFAPAWLGDLILLNRIPLKDTVKVSFVLIPWQDKLPHLPSDEGKNSRLNANRMLRAKKIAAYVAERLEPPFMVLSFGPEVKEGQLPPKPEDWLELLCHDQVVPPAMTLATIRSYVWKAHGDVVLYYRRKDEAGVSPASSTTAVEVEKETNGEEGAMGNVTTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG70</accession>
    <name>A0A2T6ZG70_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="13" type="ORF">B9Z19DRAFT_441596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG70"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG70"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="12">
        <location>
            <begin position="142"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="10">
        <location>
            <begin position="357"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="145"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU74469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="485" mass="52649" checksum="420CE609A257FB4A" modified="2018-07-18" version="1">MSVPGLQLSELPIGQPFSNFTAQDSTPVEPLAEKTYEVAKFREWRFEVAFGTTVEVKLLKGSAEIFGTELPIGHKFTFTGAKSAIFTWHGCTLEVRGSPSVEYTSEETPMTAYTNLHFALEKQRGMAGESPTVQGPRVMIIGPENAGKTSLVKILTAYAVRQGRKPAVVNLDPKEGVLSLPGTLSATSFSTIMDVEEGFGSSPTSGPSPVPVKLPLVYYYGLETPEGNTKLYKALVSRMAVAVSSRLSEDDENRSSGIIIDTPGTISQTPTGYDLLHHAISEFSITTLVVLGSERLYSDMLRRFEDRPNHQHQPPPISIIKLSKSGGCVDRDDAFLRAARERSIREYFFGEPKKRTLSPYTMTVGFDDLNIWRVGEASTLNTSLLPIGHDDDDDEGGGGGVGGQALLAQAECSMLLQHSVAAVLHAEIGDEVRALAESSVMGFVYIASVDEQKRYMKILAPMPGRLPPKPLVVSSFPEPTFSLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGS8</accession>
    <name>A0A2T6ZGS8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGS8"/>
    <dbReference type="OrthoDB" id="10593250at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="21632" checksum="1746428FDF3317A7" modified="2018-07-18" version="1">MCLSNRAPSCGGAIATLQSPYTPHSAWTGQVFFVNEPYPTGTTSCNEDGRTGSRSSSSSSNNAQTTTTTFVKCQWQTPIPRSRTCPSISTSSSNSIPSATDAVCRLRIHEFAHDPLSVHNAILHDVLLRGGDGEEKEEVVNLGKELVLGVGGDGIIGRGISIVIVGGAEEEEEAAGEGEGEGKAQDGERRMREGEVVGWGVIGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGT4</accession>
    <name>A0A2T6ZGT4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGT4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="19964" checksum="6CC5A04D5BC9FFE7" modified="2018-07-18" version="1">MAGHLRVEIIQLSCRARAVLEAPSSSTTRKKELYYYSCSRKAPIPFLPVLPLGTLLNPLFLYYLAKQISIKVYNAPRGVSENSYQSGPCCSSPINKHCSWGTRKRMRTLRTWLYSSTGTVLVACFPISHLIPKKSLTLPMFAFPLFQSSPLFSPSYSRNTHSSLLSFYFLIAGQHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGW2</accession>
    <name>A0A2T6ZGW2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1092043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGW2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="68" mass="7958" checksum="99F81E24E33E0330" modified="2018-07-18" version="1" fragment="single">MFISLRHSYNNKTIFLLCQCQRIITNPTLDNCFVRSPYRIYRCRNLCGVGLSRGYRGKVKLQGGENRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH39</accession>
    <name>A0A2T6ZH39_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1067958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH39"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="169" mass="19367" checksum="C0A18106A681EA51" modified="2018-07-18" version="1">MWGKLVNVQHNGCLKYTLSSSYKYHPSRNKSNLCIKTRRIPYFHLQHVPVPQYPIPQNTQTNQLAEAPKYNPILATIHKSPLPRLSLIRMPHLSHFFLPPYDLDNLISGINPIPRAFDSSSPPPLRPSTIDRHPEVQYYSLNSPISPFTTLASNEGTFVRQETQYFNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHJ9</accession>
    <name>A0A2T6ZHJ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1091427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHJ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHJ9"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="7">
        <location>
            <begin position="160"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="334"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="479" mass="54066" checksum="A8E02B4D616156F0" modified="2018-07-18" version="1">MDLDSSSDEEDSVQEQYPLEGKYKDQADMRALLAMNEIDREALLAERAGRIERAQQNRHLRNLLKSRNAADKANGASASGANRRSTRTKSMPKKTEETSKRGKLDELRKTREERSTRAAGSGKQTGDEEDARVRRRSINEDDEDKAGYNEEIYVKEDDREILLADVNKARIGRTGLAKLCDYPGFEEAVTDCFVRVSLFDRETGSTSYRLGWVKGFVSGKYYSMLDGKRRTDQHLRVSQGLAERSFGMEFMSDSPVTEAELNRFKKQMEFDHCAMPPLSLVERKSRELRELDNRVLTQDEVNEMIKKRNSDKVDTVNIVLKRGRLRDAREAAQLKGDEAEVARVDKELQDLGDQHGKSLVVPKSQMERLAKLNAVNRKKNVAEIRRAEIEEKRAARTATVHNPFMRVKTIAKTRHNLDGGKREEEDSQNASGDSQTDAETKSNPAGLGFLSSSVKGRGRLGAGVDDVIANYDFGIEIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHS6</accession>
    <name>A0A2T6ZHS6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_996616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000256">
        <property type="protein sequence ID" value="PUU75006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHS6"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="463" mass="51065" checksum="F39823CB70BD38EB" modified="2018-07-18" version="1">MDILELIDDREQTVAESSPRPFSCPEPSCNKSFNRKSDLQRHHRIHTNERPYSCTFPNCGKSFIQRSALTVHTRTHTGEKPHSCEYIGCGKCFSDSSSLARHRRIHTGKRPYSCPIDKCGKSFCRKTTLTKHARKNHQLRTENDVSDDDAEDSDDDDLSPKTSGKAGSRAQSKRSTKAAARRAAPNRPGVLRTASSFAEPLTPHSPQSTVRSGHSSRNTSFSAASDSYPHSMPMAMTHSIHQHQPPTPQSPYYTEEDVGDGREISPNTMIQRDDEYSTTPTGPPPSLQGNRSFDTLSIVCSTPTTHQLLAAQQTLQSSPGSLSSCSSATTASCGSDYFYRAPQGTPSNHYQNMGQAISPGGIPPYPAQMPVHTGSSQHPIVMYSQNGQHQSNGMLSPHPQAPVQQQQQPVWYDYPTYQQQLLAAQTQPSQHRIYYTGVPAQDPSFVKPEPEQNLLPTPRGSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI74</accession>
    <name>A0A2T6ZI74_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1103078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI74"/>
    <dbReference type="OrthoDB" id="308861at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="10">
        <location>
            <begin position="565"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="11">
        <location>
            <begin position="749"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1162"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1181"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1234"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1275" mass="143684" checksum="5AE8E94F2769FFBD" modified="2018-07-18" version="1">MASKTLKGWSEITVYPTDASLRQFRLNCRQCRITRCYVNGRATATQHTDPYQNFRMHETSTAHQHHQYRKKLDAVLHDPPEHELVINLPSRVKIEPVPPTGHSKTDSLDAATNTATGIMTSSLLTSRTDNSLSPFAPLTIRIEFIVENIKDGFNFVGCDLGDMRYPHAYTTHSPLPGAACSLFPTLDGIHERWTWELEITAPRTLGDISKGNLPETKEKKGDTNATANGTNGLPNGINGVNGNHTPPDEDGDETLDDDNDLDIVVICSANLKDEVDGDKPWKKTWKFEQTMAVSPQHIAIAVGPFERVNLSEYRDMEAEEAMGIMIVDVMGYCLPSREAELRGTCMFIPRALDYMFKEFGQYVFQSFNLCFVDDLVSDTTESASLVICSNRLLFPESLIDPIEPVTRKLTYSLAAQWAGVHVVPKDWSDTWVIVGMAYWMANCFLKTLMGNNWYRFNLKKDAEKICELDIGRPSLYAQGFQVPIEPSALDFIKLKAPVVLTILEKRLWKVSSSMVLHRVVRKTFLGAIAGDLKNGLMSTQHFTRLCEKNSHTKLESFFQQWVYGSGYPRFEVSQRFNKKRMIVEMGIRQVQSSETPVARAVAENFMQDAMNHERHVVVGPTRPVYTGPMTIRIHEADGTPYEHVVDIKEGYTKLDIPYNTKYKRLKRSRRQKERAAAGAGVDVSIDAQNDDVLLYCLGDVLQAEDEVVDWKMEDWSKEEEDKMAQESFEWIRMDADFEWICTLKVNQPDYMFLSQLQQDRDVIAQYEALQYFSSVKESALISSIFVRTLIDRRYYWAIRVEAAMGLAKCATAELNWIGQFHLMKAFQVFFCFPESSVPKSNDFSDATAYYVQKAIPTAMSRIRNVSGACPTSAQRWILDVLRWNDNNNNNYDDCLYIATLMKALANTITITKFDLNNDFGYEDEEAIQTQKESINEIERYLRIDKWQSVYQNVLSETAVEILKDWILLGIKDKDPKFFLSYTREGTLDSLRAKCFECLVELGAMHQPGFVKYMAKVMSSDPSPYLRHRLWKVLGKGLGMIAVGSTKPVNNNVNPGFGEMTFVDDSVDMSHERQSELARETIAGAITNLKRELTDNEGFKQALWAAATSPDIGLIEIRNLLDICCLLYETKSSLVVILRQRSKTLKCTHLGDCKIVIKPEYRNWYTPRPQPPSSSRPAASSTHQDSPHAQNSTPRSGPIKLLPNSRSRGNPGSARRVKTERQSSGSTSRSAPKQAAASSGTPKASPAGGAGAGSAPRPTKIVLKLKRPLPQNGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI78</accession>
    <name>A0A2T6ZI78_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000245">
        <property type="protein sequence ID" value="PUU75195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI78"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="197" mass="21891" checksum="2871B9B9A157455D" modified="2018-07-18" version="1">MPIFLLIHYKETEIQETDTTITLPLERVGAKNLVCYSGEIQDTSTLPNTDFGDAEITEFLGEHSQGILLKAKVGTEVLRRTHIGTGSGSDGRSLKRLNGESFTALEPTTMATIIATIIDSDNNPPSFHREEFNLNNLRRSRLSNRKTDPRTLDYIPADTFQCPFPTPRPPPAFLGNHTHYPQLNPASDPNPILHILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIE5</accession>
    <name>A0A2T6ZIE5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_359246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIE5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIE5"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="171"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="377" mass="42372" checksum="AE4759EC785D13C0" modified="2018-07-18" version="1">MEVIKLTLFTRDTFSSNLSKLQDFQQKDAKALGMSKITMTRMFILDSSQGEAVELDPGLVTTVHVLQGHSNSSTGATPPLGEGDLRNGRYNNQNVLIEYKHYPEPQQATSNPEIVRDRVQFLSKLLGVECRNGEPTGSNNFTLHCLGFFHEPEESRYGLAFALPQDREPEPMSLHTAIGSLTRQSRPTLGQRFAIAHSIGYSLIEWFLVGWVHKSINSKNILFFRQERQGLDFDSPYLCGFEYARPSGGISNDALKSKGLDWDIYRHPARRGFPTETFGKIHDIYAFGVLLLELGLWQLAPQLFGPTAKPTPSVIQETLVKNARERLGHFMGQNYRDAVLLCLESSLAAELDDKRDSRLIAAFKEKVVAILEEGRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIL1</accession>
    <name>A0A2T6ZIL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIL1"/>
    <dbReference type="OrthoDB" id="5395563at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="18525" checksum="D0B534627E572B43" modified="2018-07-18" version="1">MTHENPYTWQEWVKARLLWLSVLLLLTSSAVFGMAVTETSMTTNGISISILTVALLTTFSAVFGIFSGFVPSFELHHTFLSVVLTIQIAIWLFLTMFELTEVKDIGSKENSYNSSYWGKDSGLSHGCSWADSGRYPDKDSYNRTCSLVKARFSISWVVLRGVTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIM2</accession>
    <name>A0A2T6ZIM2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIM2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="10682" checksum="626483EAB34A4DAE" modified="2018-07-18" version="1">MAKVGGVSFSLPAVALNAEVWPEHDISSQSCDEQSKAQVDVWERIFGWAGRGTRKGDGGLGWCISTILHHMAGEHMAPPTYCVVVVVAGLMVAWERSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIX7</accession>
    <name>A0A2T6ZIX7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1090402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIX7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015538054" description="REJ domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18061" checksum="FB11C74AE360A8C3" modified="2018-07-18" version="1">MHSNHLFLMSMTSLLPSSSPLPPPSSLSRYDTIYTKLTSFAVTHFTSRFLLPNSEILTSPTTSYAQLTNSVPGSSSPTFRLLTKNLPVATTTIHIAPSKYRTRTTLFNPHQSTSSKHPSFKHHHNRLPLSRYRSSSTTDLFSLPVRKPNGGYTMLGVFFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK24</accession>
    <name>A0A2T6ZK24_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal fucose-specific lectin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_307774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK24"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="433" mass="47275" checksum="41F0DA1E72AEC439" modified="2018-07-18" version="1">MSVISAPIPSFEMEHVADLERQDDFKTVTEGSERVRKRVEFAPYASKFEYPEPQYAPPSNICGIRRKVFWAIIAFVIVLNVGTIAGLVVVVNRSKDGELFSTKGNDGSENGGDANTAGGGDGEIKVDVSAFKGLPLLPGTALSAVNWGNDTRVYYQNGDGKIIQNYCGGMSCSPAQNPIITDAKYFSPLESVGRADSNNSIHIFYLSTDNALRERILSNNSTGPTDGPLSTFNTRAHSNSHISATFSNGEIKLYYQDAASLRLQELLYTPATGWKNGSQFPPAASGSRIATAIWEDNLRLYFVNESNILVEQRWATRDGWSEGTDTGREFDPRSSLAAVPPKDPSNPIVRMYSTDAYNELFTFTLKDPVGRKGVIGNVRDMADDVTATQTSDGVVSVWFVERGGDLMRKTGNGETDMRSASVRVAASDQDPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKM4</accession>
    <name>A0A2T6ZKM4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_992222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000206">
        <property type="protein sequence ID" value="PUU76032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKM4"/>
    <dbReference type="OrthoDB" id="5419517at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="502" mass="54338" checksum="D962944A1109552C" modified="2018-07-18" version="1">MATAVVCCPEPKRTREFAHTDAPSLFSSLVMKQPRTNRLAAWIHDEHAPFSEQPPAQRIQVVLYSVYKFEVDFTEQTEPANDFVAVITRLALRNGYAALSQITSASYGQSHRGHVSHSGQRNSGGAGQNAPGPTVPPGAGNGGGSPSKRPVKRGGNGDGEGNPNKKKKVSNEPQQDLSPYYCIIPGLRGESAEGDCAKPFADLPGIVNHHLRKHVGHIQCDMCFARKGTMTDMNKHHKRACAPPAKIRKEIEIHGRNIRDVKSLDELKRQVAPNGEIQYDMASNIDKLPQSSADDGNTHIGQPAAAPPQRQMNPVGTPTVGDTIIGYTHLETYHSDNSFGYPPIAFAGIDYNSSTLTDMPGTVDPLDLINSNFDSGYSDLKGSSSQRGTEFSHYQCSEIRGEASTGGGGGVQAISGDEAPEQDPSSKLLERVNWVIEAFLECDNYPGGRHIAQLCAQNIAIQVPESILRVFAEAYQNKVGQKRETQAYSPTRGTKGKGREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKP0</accession>
    <name>A0A2T6ZKP0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000205">
        <property type="protein sequence ID" value="PUU76058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKP0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="10486" checksum="7A0C537E743D370B" modified="2018-07-18" version="1">MTVSKILRARQLSTYCVLSGPDGRYGMDGDGGDDGGDDEGVRMKGMVWRMGVWAGTGSDVVDGMDGSGMKGGGGEQAGSGDVDHGGGAGRGRGGGDTNILEGDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKR1</accession>
    <name>A0A2T6ZKR1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1089062</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000204">
        <property type="protein sequence ID" value="PUU76078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKR1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKR1"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000082">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="15">
        <location>
            <begin position="59"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="16">
        <location>
            <begin position="265"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU76078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="344" mass="36855" checksum="837A49329EED8FAA" modified="2018-07-18" version="1">MDLVNHLSDRLLFAVPKKGRLHENCLDLLRGADIQFHRHNRLDIALCINHRIALVFLPAADIPVFVGEGRVDLGITGQDQVAESQAGVEELMELGFGKCKLQVQVPEKGPIQEPKELIGKNIVTSFTLLASEYFAKLEAEGARSGDDGEERGRKEGRGGGGGREGELNLDVLEKTTPRAVSRTGKVDGIVTRIKYVGGSVEAACALGVADGIIDLVESGETMKAAGLKPIATILTTGAVLIKSKHPSNPALVKTIESRIRGVIVAKKYVLCTYNISRDKLAVATKVTPGKRAPTITQLEEEGWVSVSSMVDKSSIATVMDRLEEIGAEDILVTQISNSRSTGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLI9</accession>
    <name>A0A2T6ZLI9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1088422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLI9"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="85" mass="9149" checksum="71A53EB3D8685301" modified="2018-07-18" version="1">MPLVVPGVNSKDTSALDANIANPVIPSEETIKTGVFDTEKKDEGDKPEAQHFQSMPGPVIPQDASALGEKANREELHARAQELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLL5</accession>
    <name>A0A2T6ZLL5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1102378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLL5"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="20362" checksum="2608944C9547A12A" modified="2018-07-18" version="1">MFFIHELNRTITLHPSYFGPHMKDYLIHKLHEDVEGSCTGRYFIICVIEYENITLGRIIPGKGDAEFTITYKAVVWRPFKGETVDGVVSSVNKMGFFAEVGPLTVFVSSHLIPRDIKFDPTSNPPQFSDNGDQIINKGAHIRIKLMGTRSDVGKMHAIGSIKEDYLGYDIFKYAEAFVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLS8</accession>
    <name>A0A2T6ZLS8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLS8"/>
    <dbReference type="OrthoDB" id="5510554at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="915" mass="97349" checksum="7F6A762073071668" modified="2018-07-18" version="1">MSKITEASAPFSGPSFSPFPQNPNIPIGDVLVDGVSQKTTFPTEISIESLVPYIPRGRKPLEAPTPPLSTPGYTMANGLNFGKIAFPPSAPVFGRKIKVPRGLLVGAEPAEFAFVSEKQCKIPMSPSEAIFTAGKPIKPVRKSHLLAKELEISFADASVSPGAVFVGTGYGRLDGGDEVVEELEDEVVVGARMAGVTTESTNKSFCVQGISSQDLENSLSLALQTPLPDDDEPFSEDELFTLSLALNTPLPVDTEFDLEWALPTPEIGKEPSPEVHDDKPLLDRLEGIDKVIGGLESEAIALKSHAVTSAVTYEDPTLCLSIAVETPLPDDDELSSQDASPALSPALNTLTPDTESSSEHPLLILECESPPEAESDGKPLLEAHSAVLANDMFTAEESIGRLCKHSILLAGELESSFADTPFSWETIFGGAEMGGLEGADEVINGLEDKVVESARTPGITTKGRTDKSSCTPAVSSDSSSEDLTKSLSLALKTPLPDDDEFGSEDTSLIHSLAVSTPLPVDTESDSESPVSILQRESSLKVDERELLRNTCQDIGAVGISASPLLTKVILATREPIKPLCRHIPPVSKEPGIAFHNASVSPELISGGASLALSLALDTPLPFEAESHFERPLSDLEMESPPLESADRNKPLSEALQDVAITKSPDITISMGELDTGAANGYLEKGDRERKNINAGNEQDPVGNTHPHSHSLPIKNPSLTFKANTATAECAFDLPPQNKRSASKSETYEHCQIIKNPTITPRACATTLDPLHSHTAMSCGLSSTLSSGVSTGIGTREPDPTLVGFREAKSEFDFTDIFVGLFKEVGAVDLALSTITPSTSAGTTRSWPQDLPTDEGFHKNEVAASLVGARSATSEKKLAVRKVFAKFGKASVRERVRKGAIKLFNKFSPIPVDVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM53</accession>
    <name>A0A2T6ZM53_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_990287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000185">
        <property type="protein sequence ID" value="PUU76526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM53"/>
    <dbReference type="OrthoDB" id="3546635at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8774" checksum="1B32A85696BDCC33" modified="2018-07-18" version="1">MAKGGYFISGLNYIWSIDGHHKLSMYGIEIYAGVDAYSRYIPWIYMGISTRTGISCLHQYLEVISQTNILPHSIRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMB9</accession>
    <name>A0A2T6ZMB9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1087896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMB9"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="50"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="156"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="325"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="499"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="761" mass="84568" checksum="B3507EF37ED23258" modified="2018-07-18" version="1">MAKRARIDNEDNRSSNESEVEELEQKVVPERKKKTSKSQDDAEDDTLKRRTVFVRSLPYTATTESLSTHFSFIAPLKHATVVADPVTKKSRGFGFVTFLDAEDAQKAVKQFNGADFEGRKLKVEIAEKRHRETALSEGEVKKGKTVDGEDVKKRAPRLIVRNLPWSVKKPEDLVKIFQSYGKVRDVIIPRKGNKPSGPMSGFAFITMKGYKNAENAIEKTNGMEIDGRTVAVDWAVEKNEWEQKGAVDIGEGGEEKEDEEVAVKVEDDDEDGGVGVIGDDDAESMDNASDASSNEGSDIENFSDDEDEENSTQKKLYSEEEEKSLTVFIRNLPFSTDDEILHKHFESNFGPVRYARIVIDHATERPRGTGFVCFFDKEDCDRCLADAPRQQFQVTKGKSLLQNEGDDPSGRYTIDGRILQLTRAVNKTEAAKLQEAGLAQRDKAQGDKRRLFLLQEGTILASSPAFQRLSNSERLLREASLKQRKTLLQSNPMLHLSLTRLSVRNLPRSITAKGLKQLAREAAVGFAADVKAGKRKQLSKEELVRGGDEDREAEKRRKAQGKGIVRQAKVVEEKAGTGRSRGYGFIEYSSHRWALMGLRWLNGYEVGGTAAPTEGGAGKGATRTAKEKGKGAAPPPTIEEKKKRLIVEFAIENAQVVARRKEKEEKARERSRLVAEGKAKPLGSTKEKKKQFAAKGKAATKARGGGRGFSNGKRKREEEAKDVREDSSKKAKKDKMAPKAARIIARKRQVKRRVGKGGCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMC0</accession>
    <name>A0A2T6ZMC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1087889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMC0"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16170" checksum="93B7AAFAD7060D3A" modified="2018-07-18" version="1">MAPKGKKVERKEENISLGPQIRDGELVFGVARIFASFNDTFVHVTDLSGRETIVRVTGGMKVKADRDESSPYAAMLAAQDVAARCKEVGVTALHIKIRATGGNGTKTPGPGAQSALRALARAGMRIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZME3</accession>
    <name>A0A2T6ZME3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alb1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1087823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000180">
        <property type="protein sequence ID" value="PUU76660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZME3"/>
    <dbReference type="OrthoDB" id="5304887at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14472" checksum="E3FCA46386D7E902" modified="2018-07-18" version="1">MSKTPKPKPHPAPRSRAAKRAHPSPTATIPLPRPDEKPTSEKLAALSARTAGSSVQKRKGGKAQLSRQKRRRKEAAIDKAGAVLEKLERRREVSARKGGVVKGRSTDWDNLNEIIEEEVEKAVEGGKEILVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMF6</accession>
    <name>A0A2T6ZMF6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMF6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="12202" checksum="609647CD7B779ECE" modified="2018-07-18" version="1">MPSTREFAIHAMLSQFDKRDRPENQQQDRNGMPPGAILAIVIAALTLLVAMIPLFQCPRFHHWVSSSIPPISRACSPLLTLPEPIQIYILNLVILYRKPTELPFQATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNT0</accession>
    <name>A0A2T6ZNT0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1115548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000161">
        <property type="protein sequence ID" value="PUU77149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNT0"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="242" mass="26791" checksum="0CBB2B61CB6B97E3" modified="2018-07-18" version="1">MPNKKGRSKNLLGIDYDLPTPTAQPPTKKRKRSQKTDDDTPKEFTRLLSRIQRNKPKPNGLDDPPMKARKSHLIPELKIQPSESLRQFNRRVNASLPITLKPEGSSKAQRAKEKKKKEKAKSTPVAGSGDDSDSEGKAWSEEGERGKRKRGRNKGRAGSPDPWAALAEKRQAVKFSDLAKAPPTLVKPKSVLHSRGVVDVEGIPKSSGSLAKREGLAGERRGIVEGYRRLVEERRREKGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNV3</accession>
    <name>A0A2T6ZNV3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNV3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="10617" checksum="6983DC6E0CB3AD9C" modified="2018-07-18" version="1">MGSHTMVKCKMQCMFWTFSFLHNYFCSILPRHCFHFVRDNAYHFLRGLPSRPNSSFFLHKVMIGAFFLFLFFLKKIPPSDSYPYSSETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNZ5</accession>
    <name>A0A2T6ZNZ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNZ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14269" checksum="04126F3D4E7291D9" modified="2018-07-18" version="1">MIQTHHCRKCSKVTSSRCFKKCGLQICHLHPNHAFGANSTCRACPDPRGLVIGQESEIAKESKKTDALPEERTGPKEQGRVRRLMEEQKAQRGRSEKSRQVSQKKRAENSGVRYAVKGKRPERRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPV2</accession>
    <name>A0A2T6ZPV2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1065807</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000151">
        <property type="protein sequence ID" value="PUU77496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPV2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPV2"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
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        <location>
            <begin position="378"/>
            <end position="425"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
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        <location>
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            <end position="97"/>
        </location>
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            <end position="187"/>
        </location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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            <begin position="11"/>
            <end position="51"/>
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            <begin position="592"/>
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        </location>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="PUU77496.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="689" mass="73586" checksum="DEB7A286034430A8" modified="2018-07-18" version="1">MPGKLLPNPLAMASSTSTAGVTTVAASAPVVIPSSPSPTTNLPTTTTTAATQPPPPPTLPSPTLELAATLAIDTQPNTDTLETSTSNMSVQDHDRDATVDSISQRVSMTLQEHAQHAQQSIKQQQDLQQLQQVAQQQQQQQSQNQLSSQLQPQPPPPPQQQQQQQRRQIQQQIQQEASPGPSGGQVCSNCGTARTPLWRRAPDGQTICNACGLYLKARNQSRPTNLKRPPHGSTIGSLQSSLGATYVAADQVASGTCPGGGRCNGTGGAEGCNGCPAYNNRVSKAAQFTVAASASENGIPMDPALTSQDTASPCPSTPAQQTQQQQQQQQTQRQQTQQAQQSRRASQPQRPSQIRQPYTQATVVRTGSPTNTTVVVACQNCGTTITPLWRRNESGHTICNACGLYHKLHGVHRPETMKKSVIKRRKRVVIPVNGNNNTAPAPAPAAAPGNEFHQQLSAQTPTPAGRADSFSVVQQQGQQGQHGLQPTDVSDDDMVMTDANGNSLRQRQLQHPDPEQRQYPPLVDFTGAFRQDKTDNNAPASSTEADSNQTSIPSDLSNSSAAVLAQLSTGHPSQPRKRSLSVAEADGDNQRTHSINSILNPHGQMSNVPIEPSLLALGTGSSETILTEEQKKQLLLQRKNDLERESKRIKAEMEECDQELEKLETAASATPGADQVVIMANGISTAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQN6</accession>
    <name>A0A2T6ZQN6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000141">
        <property type="protein sequence ID" value="PUU77787.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="61" mass="6450" checksum="2EBAA59C714F080A" modified="2018-07-18" version="1">MHSTTLFGHSSITTLSTEISPHDPKTTKQTVAASLTKESGYFLGAIPSAAETFSPVLNVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQR3</accession>
    <name>A0A2T6ZQR3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_134785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
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            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000139">
        <property type="protein sequence ID" value="PUU77829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="42251.A0A2T6ZQR3"/>
    <dbReference type="OrthoDB" id="5356691at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="27545" checksum="F67E5EF2BB145E0E" modified="2018-07-18" version="1">MQTKKMPSLSEKPPRPPPVATTRPPSYPSSISSTTSLQKSLLLPPLTHITTRLSRPPPLPTSSTAPLYISRTRFLLRLIAALFSFAILITISSIYSTINRTFPRHMLYNGRDLWPDVINLHPTTILLAMSSVTATLSTIVLIAGLKPEVRHVGGLGDWLNLGVSGVSLVLAAVGTGCLIGGEGKGDTVWGWTCKNSGVDHPDVQFWMVCGELKFVFALGWGIVAVEALILVNVVVGYIVVRRGVLGRRGTASQAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRL5</accession>
    <name>A0A2T6ZRL5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Calreticulin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_984231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRL5"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015374684" evidence="9">
        <location>
            <begin position="26"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU78131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="507" mass="55961" checksum="C05560F9AE2500BC" modified="2018-07-18" version="1">MRFNTKVALGLLSVALMGFGNVAFADEIDDALGDAATSSADSSSTAPVINKPTFSPLAINAPFYEQFTPGWDSRWKVSHAKKENDKTGDEEWTYVGQWAVEEPVVFKGIEGDKGLVVKNVAAHHAISAKFDKPIDNKGKTLVVQYEVKLQEGLECGGAYLKLLKENADLHAEEFSNASPYVIMFGPDKCGATNKVHFIFKHKNPKTGEYEEKHLKSPPMARITKQSTLYTLIVNPDQTYAIKMDGSQVKSGSLFEDFAPSDWDEDAPYEIVNELAEKPEDWLEDEPEFISDPEAPMRPNPAYKGKWSAPMIDNPDYKGPWAPRKIPNPDYYDDKTPSNFEPMGAIGFELWTMTKDILFDNIYIGHSIEDAEKLQKETFDVKKKFEQEEDAASAPKIPEVPKAPGETTFKEDPVTFIKDNLEIFFAAAQKDPVFAIKEFPAVAGGLGVILATFIAIFFGLIFSGSSPAPTPKAAASSDKKGKAETTPEGSSTESEKPKATRRTSKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRZ1</accession>
    <name>A0A2T6ZRZ1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_87655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRZ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRZ1"/>
    <dbReference type="OrthoDB" id="5366541at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024737">
        <property type="entry name" value="Get5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12754">
        <property type="entry name" value="Get5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="33579" checksum="B8395C4476EB862B" modified="2018-07-18" version="1">MTELSFTKQFLSTLSSRPIRISADFCEDARKLPARTPYTLPKTSKPKSKKAPPASSATSSISTVNITLRSLRGTPIVHPLPAAPLSTTIISLKHQLSTASKIPIEKIKLLLKGRVLGDLKTLEGVGVKAGEEEVVVSVMVMGGGGGGGRRRRGGRRRRREKWRRGWRERELLWMRPFGGICGSGWIGGLEGSLRRIWWGCLGRGGGRSDGGREGEVALCCTVLEWPSWGWTSGNNSHIECPTLARPCWCLQTSGWWCARSRTLISFRLQCFVIVHNSLSFLFFSPVVHRWGIIVGLMIPVSFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSY4</accession>
    <name>A0A2T6ZSY4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_983024</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSY4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSY4"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU78534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="711" mass="79751" checksum="2A9BDCFCD20AEF63" modified="2018-07-18" version="1">MADTGIPTHRKLPLPLSASITNIPPITVLADSPPTICRLEVAPHFAALTPKEKLYAHHISRASFLGTRVILRQVSRESEAIYDLILALYAACAGDWKKLGSESSVSEQDVQYWLQYATVFLGSLGNYKSFGDLKFVPRIPKVELRKLVEYASGEARKLFDGVEEVMYSVVPEERNLIGYIDAGHVSAYYPDSPSITKAEIEEVQVVTAANGILVENTRLRKVSDSEFHLLFASADTTAPEGQKTEFVFGEGGKKLKLVYGDYVELMKKISTECRAVAEYSANEIQRKMWEEYARSFDIGSIQAHKESQKYWVQDKGPRVESNIGFVETYRDPAGVRAEWEGFAAMVNEERTRTFGELVRRAEDFIARLPWGKDFEKNHFLKPDFTSLEVLTFAGAGIPAGINIPNYDDIRQEIGFKNVSLGNILSARSPNEKITFLKPDDATLYSKFQGPAFEVQVGVHELLGHGTGKLLQETSPGEYNFDHTNPPINPITNKPVETWYKPSETWGSVFGGLAASYEECRAELVAMYLGVEKDLLSIFGHADDQEAEDVLYIEYLQMARAGLLSVETWDPKSQKWGQAHSQARYFILQVFLSAGDGFVTFSHSLPDMSDLTISIDRNKILTHGRKAVGEYLTKLHVYKSTADFRAGSELYKRMTEVTDQFKGYREVVMRLKQPRKVFVQANTVLSGEGGVELREYEDSVEGMVKSYAERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT08</accession>
    <name>A0A2T6ZT08_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1126489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000113">
        <property type="protein sequence ID" value="PUU78630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT08"/>
    <dbReference type="OrthoDB" id="5357315at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000364">
        <property type="entry name" value="Protease-associated PA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF406">
        <property type="entry name" value="PA AND RING FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="508"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="438"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="558"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="591" mass="63210" checksum="34F88318CD853A0C" modified="2018-07-18" version="1">MPLTLTRTLVLLLSLLSLFCLFLYVSLTNLSPAPSSSRNRQSAANFLFPSTAIISLSDDNSTFFLSRPAAFGPSLPKSGLKGELFVLEEGQLACDDTPGWDPSSSPPVSMVGEDGTDDFDYAPESLTATVTKPGGAHADIESLQQSAEIEGKIVLVTRGGCGFLEKVLWAQRRGGVALIVGDYKRSGGAIGGGALVTMYAKGMRKICLFVLFELFGNGGEARSDTSNITIPSIFTTYTTAKLLTALLPKHESLPFRRPNTPTPVAGPVPKSGGERKKVEEEKVGLRVRWPLEKRNQAPPELQLAGTPAKSKKTTSAGGTATPTSPLAGSGAHLDSSHRSPKSAGLDGSVFTPNPDEGKPRDENDAKGGDKDGDVEKDGLWITLTPTSMSSSPFFDTLFVLVISPLVTLTVVYALLLVRSVIRRRRWRAPKSVVERLPVRTYQSTPSTSAPPPPRRTSSLPLRNNRERNVSNASSSRSVSAPSAPEKQNKEYIHQSPPRSGYQGGSVECVVCLEEYVDGVSRVMRLPCGHEFHAGCITPWLTTRRRTCPICKGDVVRGAAAGGPGPSWGRHSDAGEASERTPLVTGDGEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTH5</accession>
    <name>A0A2T6ZTH5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dolichyl-phosphate beta-D-mannosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1141335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTH5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTH5"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="16275" checksum="AFDFF4AE56F3E16A" modified="2018-07-18" version="1">MAPSQPTKSGKDKYTVVPPTYNERKDFPIIAWFLEKTFTERTQVVENQLNTVYGANRLLKPPTGKPGPDRVYLYRLHFAMGNFVTIMYADLWHHPKFIADFITLQKTKDYDIVTGTRYAGNGGVYRWDFKREFRENGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU06</accession>
    <name>A0A2T6ZU06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU06"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU06"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="47"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="268" mass="30422" checksum="BF7A8D7408A16069" modified="2018-07-18" version="1">MSCRNCGNCYGYCGNHYQQVSIYGSRPAADSPTTKHSPEYKDFLFGGNVTLYVGPKRKRMEMHKKLLASISPELDKHVNNNMREGVEGIIYLPDEEEEVLTLFTEWAYTGNYTRKDYALPVNTINTMEPKRDPWPSLHKHLQLCAFAEKFNVPILKQLAESKFYTEIGHVTIEPNCSSDPSGLFLVIGYAYDNLPSSDPVLKFLAQYAAWKLALLRETTAFNVLVLSQPDFLKELLRNVNGPGARPMAPQKHTQQAAIAYRQPYPFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUP9</accession>
    <name>A0A2T6ZUP9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUP9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUP9"/>
    <dbReference type="OrthoDB" id="3171351at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="711" mass="82124" checksum="F73AA5F41B0EC1F7" modified="2018-07-18" version="1">MNQLRVENDLITQGITSWEPKKLLGYIQEKLSVPLNAVDAEKFLEAQIDGSVFLFGAGDRSFFQNASLSFGSSVKLAGLSENIAGRYRNSEQAGLTWPCDHIFKKLQSECEIDTVVRELSSLTSQRRSQIYHECLPLSKEMLSDPAFMTKLPFPFVFNTLPNRFKFESKNNEHNWIYTGREKFAELLDKFQEICKSPHNSGFWLHGTRGYGKSHLLAALVCYLTARGERIVYIPDCHECMKDPVSYIKTAMLFAWADDDDQRESIILLKTMEAIYRYFLRARNTIFVIDQLNALGCMTGDSPEQEEKKGKLETWLLKYRARHKSILSASANFNTYLQTQSTQTSELQLHVYGGLTAKEMNHWWERNSAIILEVNGEVDLGVAVLRKVWKQAESYCEYVNACIRHQATPTSVDPKLIDHRYFYERCPTSATPYEIGAYVCGIARDAVVKQLRKFGENKFADRDFLKSIDEYINNEAVIGFFIEENILSTIALRGLEIGRNISQSMDMQMFQRFPTFSITERPILYCPMQFNFRAIDGIIVRFDLSNGVNGKKGKCFMFPLQITIAKSHADSEYEFFKDWIEWIKDLDHYDLEVVFLWISAKKPWERKVKRYPEYISKNVHISDVNRDTWERYDRALKSKNGRGQTKAMVPQKRGLRKQDMREQEVVKDESEIQRVTKATKRRRTNRAVSKDGVEGSDGVSIWAGRTRSAPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV98</accession>
    <name>A0A2T6ZV98_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12/S23-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1046800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV98"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV98"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24029" checksum="AA509200D254A7C2" modified="2018-07-18" version="1">MKESWSASADYPAFNFTKPIHLPYRTSNFTSSIIKTHLPLKKEETTSPLTTTTTAAATNNVHPPPPPTLPPPHPSLPLPLTRTFTTTPHPRATFNQVLRGCRKPQPKRKPESPAMSETQNPCMKGVCLKVFVMAPKKPNSAERKVARVRLSSEKVVTAYIPGEGHNVQQHAVVLVRGGRSQDCPGVKYHLVRGALDLSGVPNRSSSRSKYGTKKPKKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVG3</accession>
    <name>A0A2T6ZVG3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000091">
        <property type="protein sequence ID" value="PUU79466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVG3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="20195" checksum="337EDE04483E02AB" modified="2018-07-18" version="1">MPIAGGRRSDHNRQETLAYPQMVSIRHPKSTELYRDITEKVRSIKMRLVEKEILSGEYAPPQNPQASRRRSGPLNVFMASKNVIFCNTPIDLCGRSNFALTGLGDSRYTSQARITLQISQAVPSLVDRHSTLSYLTWILDSRRMGFSAAGDAIVESARWTPSTTSIFSGLADIKAELTQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW65</accession>
    <name>A0A2T6ZW65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sec39 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1124713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW65"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec39" evidence="6">
        <location>
            <begin position="18"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="754"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="806" mass="88342" checksum="C508A1388D52E644" modified="2018-07-18" version="1">MSASNLRPASELSAAKLIILAAHYASSAELKPLRSLFSLHPSTFSKEVQLRVLLCLPETTKPDLYVPLIKGESRETATEVDTAPVSKISEKTANKRLKELPTLTLLENGRASDEGVLLSYLVCRARNIDRETGALSTVIELLSPFVGVVTGIDEYLKGIVDILARLTYDYASEDVGAGEEAEDESGRLEVFEGFEARVGIRLLLARCGGRRVVNDLERLVGPYLGAKKNDREGWEVVWEWLKFKITGGNWGDFVEVVTKWNGPVEDQGLAEEYARLSIAGCYVCRETEHSAWEGMRAIHRRCSKYINESQGSKDQKLPWRFGDPFDKANPLTTPNEASLQLLDVLISSAEVLSAPLANVAEIRLEGSREDQEALLVGHVRNGPNWAKRSDEEWRRTRDSVKWLQTKAKIFDKLTAKEVEKVLLSAMLAATKFDLVKEIYVNGRNGSLGKDDVETGILDAFQGFYDNASNGNKTRGSMKNALAALQILYPQTSKSTALERAYRLTNATHALSHYSLTLTPGIPLLPVQIRIHSDPVSLAARLLDSNPKSFAQAETLVTIARDLRFGTTGTDGGKKTDARVIGMCIEAALSEGDFETAYSLGMNRLVVMIAENEQNVDEDVADMIWRACFQAGRYRSPYAALVGETAAFGGKALRTVEMRMELLAQALRFCPPSALAEVLTSWRRCEEEMLAGLKEEEEEEEKQEAYWSYNNSGEKTNTATSVSKRGGDETPMGLFAVAAGAAKALRGTAFPLSTTRGDIVPPGDDAAAAAAEEQRTRKRDMVSGMVTSGLASGLGWVLGAQPNVNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWT1</accession>
    <name>A0A2T6ZWT1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_772213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWT1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="21403" checksum="385726D518D4AA3C" modified="2018-07-18" version="1">MQYSFFPHGSTQLFGVRSTKQNGRDGRRKEGGGNKKKKKAKNNNYHHHHHRNHAVPQVPGLSPLTIPKEKAVDHFRLLFTNRHNTGRYPHRRESSKLGKMPSRVKSSHPCLVFLPSDAQGTIMIRYSQDQAQPAPPQACTPTHPQAKTSSLRSRGKKMMMQARSNFGTDRLDMVYASLVWHWWDKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWW1</accession>
    <name>A0A2T6ZWW1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWW1"/>
    <dbReference type="OrthoDB" id="5421422at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="576" mass="63807" checksum="7A304A6387334C61" modified="2018-07-18" version="1">MTTFPPTPDASPKVKNSLLLNSAPSPASSTSSVTLADEPPACVSAEDDDNSSSPSPLAASTSSRTHGNSSPTTPQSIAKSPKCTESETVPCMPPPPPSSPAPIGDFQRVSPSTHHGAAVGFDSLPPTALVEIFGHALRGDCGEISSNFIEYTDPRFLNHNFCALLERRRSLSRLSRLNRFARAYLQPHLYSPAVVTSMAQLNSLSGYYYPEVDWKKKGKQPVLETDGNGTLVKPRLPVKRRKAFRGPGRKIKELVVIIAGLPGGMLEDNPSVRWPGWYIEDWMRYDLEALAVERLTILAPSQVTAATILCATIPNYQTIKHLHIEVNIGEPAFAPETRFYNSAAHDSTRDHLCPRLVLHNDTLESLTLRNIHVCRHLFDQTNTWRRLRHLNVTFHNGLRGLCCADTTTNEPATPELEVSETNRKIWEFCQQRQYLTIEMLAWYDFWSVMPGESVCSWRTISGLLYRRVTPGGQLAFLPYEWWKALSDGTVCYATPGPSPAGTRIVNDSAEEEVEEEEEEVEECSEDQEEEDSILLLDTQFSDVDGCLNGGGGVAVSQEEDIAILCAATRPRQMRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX67</accession>
    <name>A0A2T6ZX67_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1045432</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX67"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX67"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="191" mass="21270" checksum="0B16A1BB57FF430D" modified="2018-07-18" version="1">MAARPKANLYALSGLKNTSDDSIAPYLKSKGWKQNHTLTDVRLVLGFSAVTIAGSTFYYDYTLGFDKTKVMTLYAVIAYFVINTVLTWWIWGMEGGKVYVGSKDGVTITISSHTEKHSPIYHLKIVSQSLKQKPTTTEAESPFTSWFDTQGFLVEKPFMTFISNSIPSMAATTPEGQHLKPKTKPKSTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXB4</accession>
    <name>A0A2T6ZXB4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="7">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1080043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXB4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXB4"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="637" mass="71562" checksum="FC7CCC39FAAEB083" modified="2018-07-18" version="1">MLAKIITHEDCQDILLDIGMPIGHKNVRYNCRVIVHNKRILLIRPKIHLANDGNYREMRYFTGWGRTKYVEEYYLPRTIMTITGQRKVPFGDAAISTLDTCIAPETCEELFTPNSPHIGMSLDGVEIMTNSSGSHHELRKLQTRIELMTEATKKCGGIYLYANQQGCDGDRLYYDGSAMIGINGKIVAQGTQFSLKDVEVITATVDLEEVRSFRFAPSRGVQAVQNTPYQRIEADISISAPSDKVDISLKPTPTIDVRYHSPEEEIALGPACWLWDYLRRCGGVSGYFLPLSGGIDSCATATIVHSMCSLVLEACENGEEQVIKDARRVCGEPEESTWVPGTPQELAGRIFHTCFMGTKNSSADTRARAKDLADAIGAYHIDLNMDSLVKAVTDLFSFVTGKRPQFRVHGGTKTENLALQNIQARLRMVLAYLFAQLLPWCRGKQGGLLVLGSANVDECLRGYMTKYDCSSADINPIGGISKTDLKRFISYATTKFNLPILHSFLTAIPTAELEPITSTYVQSDEADMGFTYDELSILGQLRKNHKLGPWSVFNRLLHEWGDRMSPRAIATKTRNFFYYYAINRHKMTVLTPAYHAEQYSPDDNRFDLRPFLYPSFSWPFGKIEERVAAINAREKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXC5</accession>
    <name>A0A2T6ZXC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_761198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXC5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="27870" checksum="4065FB5173BBB092" modified="2018-07-18" version="1">MESVSKKRGSSDAVLIPVPGAKGRSSASLLRGGFGPVNTLNKPQHSRSPVRTKRKLTQSEALADQPFRPKRQKEEDSIVLKNLSGSSASTVKDSDAKKSKYFPQTARDTTFEPPQSSSRAGSEETVDSFTALVNSVPEIPSTRKMLDPSSWVSKSNDPQHTRWKTTPPKRTQVPPKKPVFFPLTRFQRGSTVVENTCSHENCRGLVIEKSNTKDSKEYKVMHGPEEVKDLTFQVDKIRKIYVTQRSVRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXE9</accession>
    <name>A0A2T6ZXE9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1100456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXE9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXE9"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="125"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="361" mass="39780" checksum="5A412C44C88CBB0C" modified="2018-07-18" version="1">MQSNAPTSPASAKTIDLESSSATLADDRDDKERDQSELVHLSDSEETAAQKLQASVQMSVKDDDPRDIEAVESSLEHMSLDEDEWPKEDLDEPLDLHQAMIGDNAVELIAPKTAKGKAKVERPNRRSVPADTPAIIILDSMGYGSSSRPTTIKNLKDYLAAEALNKRNLEITRGDINATYAKAPNQNNYYDCGPYLLHYVERFFEQPKEFVAAFLAREDVKLDKELWRKDEIKGMRSKIFNVIVDLREQFENFELAKATGEVKRNGLKKDDNEGEAATAGGGKKAEVSVREEEEIEDGDCVMEGEAVVDGPSNTSKLSSPKSIMSTSRSPASRSQKKRDEGSSRAGEVLGIRSKPKVSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXY4</accession>
    <name>A0A2T6ZXY4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SMP-30/Gluconolaconase/LRE-like region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1100302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXY4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXY4"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="5">
        <location>
            <begin position="23"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="382" mass="41463" checksum="4E9B21E16DA63D34" modified="2018-07-18" version="1">MSPNFKVIARTGEPILHREDFWLPESPVHDEETGTTWFTDTPRSVIYGFNVKEGQKSLKRLEVGELVGCLALIDGDKEHLAVGAKRGFGKVDIETGKLEYINTLFPGDKDKQDLMRVSDGAVDVQGRFWAGSMRSFGLGPPQNEGTLFRSDPTTHLNHIKYPITHPNGIGFSPDNSTLYFVETQLRTIFAYRFESETGGISHEQEFIKFDEDKHGPGAPDGLAISSDGDLWVAMLEGHKVLRIDPKTKNVKGVIEVPTSKQVACPAFVGEGMIITTGKLVELDPDVAKTSAHAGDIFYVPLPGITGREVYKAKFDAVPEDPGTTSGKLVSASKGKGKEEKEEEEEDATLTGAVAPLVAEKPSASITTSTTTATVATRVTGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYH3</accession>
    <name>A0A2T6ZYH3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vesicular-fusion protein SEC17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1063361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYH3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYH3"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="32263" checksum="49AEAD957A504A46" modified="2018-07-18" version="1">MAQDPRALLAKADKQAASARGGFSFFGGKQDKLEVAADLYTQAANAFRVQKLGKEAGQTLEKAAAIQQEIGEPDDAANSFLEAYKAYKKDDPSSAARVLEKAIQHYTLRGNFRRAATSQQNLAELLELEIGDIPKALAAYELAGDWFQSDNAEALANKVFLKVADLAALEGMYPKAIERYEGVARSSAGNNLMKWSIKDYFLKAGICHLASRDKIALKKALDSYVELDPSFPSTREFLLLNDILAADDDNDAEAFADKVFQYDQMSKLDKWKTTMLLRVKNSIEEDDGDDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYT7</accession>
    <name>A0A2T6ZYT7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYT7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYT7"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="440" mass="47276" checksum="A957B101C681519C" modified="2018-07-18" version="1">MIATNTQPDSGAYHCSSLQHTPTSGSVSSDQWPSARPPSGTSTPVQPTSRGATSSAFRNPSVLSSLSTSQPIVAAAPPPGTASSASHTQTTPVSFEQSHPLPSGGNAGPEQPHLSSSSSATVTTGPTKRPSDEGEEDTASPVKLQNLSHVVDLAKEDHRPRSPPKRSRGADEDRQRYEISGMPVPDVIEMVAGLLTKITTTNDRQHDQLHRGIPPPEATSGLSVTTNSVLAFHGKNVPSITILSYLSRIHKYCPTTYEVFLSLLVYFDRMTERVNKNPHHNWRTGTVDASSDLDGSPVPPSTASSSTPSVTDAFNFSHFFVVDSFNIHRLVIAGVTCASKFFSDVFYTNSRYAKVGGLPLAELNHLELQFLILNDFRLSVPVEELEAYGTMLVQFYAREAVSGANLLDNNINPPLPLSQPPTQPATVETETSHVENGVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZF8</accession>
    <name>A0A2T6ZZF8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_912303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZF8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF654">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="18"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="19853" checksum="11DEDF77C09D7A58" modified="2018-07-18" version="1" fragment="single">DFVSIPVTTEPTRPQPSSIDFSIPVRETTFIIGRSGSGKSTIGNLVLKMYEPLSSEITVDGLPLNSLDQEWLRENITVIQQENVLFSETIFRNIAFGGKDSRNVIEDQIRDACRMAMLGDAISELPLGYNTLAGVGGKQLSGGQLQRVRAYDSLDTVILILDEATSNLDYKTRSSVKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZS2</accession>
    <name>A0A2T6ZZS2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU80997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZS2"/>
    <dbReference type="OrthoDB" id="5402279at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="281" mass="30861" checksum="4334D709869C89FE" modified="2018-07-18" version="1">MSSPPPEVPEEVDVVDAIAPPGKLYIRYSTETSTSNHRWRHACFDVSTITPGDIGGLYAALCSTITTDLQRLQHERKLASKRASSFGMGSLAPGAETKYEPLNCELRIEHCRLLDKDGKLVLPPLGKANVVAVEGKEGWERVGGKSKRMDLVEWLLSAAVIEVSSEEEGAVVWGEEVLQGLLFEEGVNWPWYCIKVRFVFESRLDLVLKHHARLVEAGIDPQTFFPIPHPTLSPPPPAVPKKDAKPAPTTAASGSAIRSRKVELVRAKSKTAFTMKSLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZZ3</accession>
    <name>A0A2T6ZZZ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1078048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZZ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZZ3"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46018:SF2">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="416" mass="45308" checksum="27680CE531006344" modified="2018-07-18" version="1">MPPSIILFPLGTSSAVPAPTRNQSSLALVLPTGTTLLFDCGEGTQNQIQHLKSSYSIKHSKISKIFITHLHGDHVFGLVPLLTTILNGAGGAENDPRVLGKGEEGRKRAVDVEIYGPRGVRGLVRRTLQTTYTRLEGGFVVHELLFADEDGDKEEGEDGEECLGEVGRGRDIHPGKDGFWKDFLEVDNFLVSAGEIKHSVPCIGYVLTERPLPGKIPPEYAKSISKFKPELIRAGHPNPMSFLADLQRPEKLGLELTLSLPDGTVLTRPPVVRGRKIVLLGDTSDPSLIAPLAEGADVLVHEATNAHLPGIDPSTKEADTYEAVEERARSRGHSTPDMAGRFARRLGLGKDEVREGLLVLNHFSSRYKDDEADGADGMAMRIMRGIRKCAEDAWGVEEGKRRVICARDGVKIEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0J1</accession>
    <name>A0A2T7A0J1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1099878</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A0J1"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="281"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="486"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1095"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1920" mass="215634" checksum="7671D5CE7934F756" modified="2018-07-18" version="1">MPTLPDQEPSPAFQWLQHLSRMDEALAHLPAFPNSHLPHPSEYGLDLPLDEEPTESFRIADDLFDDLSLDGALSSPPTDDTAHPLSYDYSWLLARCRAISTRQRSAITAVDLSERLLNGGLQSRLVDLLGLDELEFVLDLIVHRTDLTPLGLSRPSLSTPGSALQLLTREEREHALGQSELEHKSRPLGPKYSQPVASYPHVYRAHDAGNTLSFSGKKYNLPLGSQTIDQKEYEETTIPATKVGTVRAGEKLVQIEDMDTLCRNTFRNYKSLNRMQSLVYPVAYQTNENMLICAPTGAGKTDAAMLTILHTISLNCTPSPGAASGEASIYCNKDQFKIVYVAPMKALAAEIVEKLGKRLRWLGIEVRELTGDMHLTKAEIVRTQIIVTTPEKWDVVTRKSTGDTELTLVARTQRQVESTQSMIRIVGLSATLPNFVDVAMFLKVNLSQGLFYFDASFRPVPLEQHFVGVKGKPGSKFSNENLDKTSFEKVKEMLQQDHQVMVFVHSRKDTLKTARLFYQMAVDEMCLELLDNTGHDQYNQVCKEMARSKGRELRELFKKGFGIHHAGMLRSDRNLVEKMFGDGLIKVLCCTATLAWGVNLPAAAVVIKGTQIYNTQKGSFMDLGILDVLQIFGRAGRPQFQQYGIGFICTTHDKLAHYLAAVTQQHPIESRFAEKIVDNLNAEIALGTVTSIEEGIQWLGYSYMFVRWKKNPLTYGIEWQELSDDPHLYSQRKKLIVRASRRLQQTQMIIFDEKAQSLTPKNIGRIASDFYILNNSVEIFNNMMKSQATEADILTMLSLSGEFDNIQSRDTESQELETLRKTVCPCDIGGAKDTSHAKVNILLQSYISKASLEDFALVSDSAYVAQNSARICRALFHIALNRRWGELCQVLLSICKSIEKRIWSYQHPLAQFRLPFHIIGGLVHNQKMGPQISSLLAIFPTLNVDTEIAPLNRDVLRIHLYITPDFRWDDKIHGNSESYWIWVENSETCEIYHSEFFILRRRKLYDDHELNFTIPLSDPLPPQIYIRAVSDRWLGAETVTPISFQHLIRPDTEAIYTPLLNLQPLPITALKDERLEMIYGKKFQYFNPMQTQIFHRLYHTPSNILLGSPTGSGKTIACELAMWWAFRENPRSKVVYIAPMKALVRERVKDWNARLTAPMRLKLVELTGDNTPDTRTIQDADIIITTPEKWDGISRSWQTRGYVRQVSLVIIDEIHLLGGDRGPILEIIVSRMNYIASQTDRPVRIMGMSTACANASDLANWLGVKDGLYNFRHSVRPVPLEIYIDGFPEQHGFCPLMQSMNRPAFLAIKTHSPRKPVIIFVASRRQTRLTAKDMIAFCGLEDNPRQFLHISEEELQGLLSQVKDQSLKEALQFGVGLHHAGLIESDRQLVEELFTHNRIQVLVATSTLAWGVNLPAHLVIVKGTQFFDAKTEGYKDMDLTDVLQMLGRAGRPQFDTSGIARIFTQDAKKSFYKYFLHTGFPVESSLHKVVDDHLGAEVSSGTISNKQDALDYFTWTFFFRRLHKNPTYYGLEIPPEEQDSALAMEEVNHYLVGMVDNSMLELSKSGCVIAYPNGDLESTPLGKIASYYYLSHKTIRNLVRNAKRQATLEDCLEWVCTATEYDELPVRHNEDLINVELSKALPFKAEKLGLPMWDPHVKAFLLIQAFISRIELPISDYITDQNSASIDVLAELGYLSTTSTMITLMQSIKQARWPNDGILSLLPGIEPSTEKSLRENGAIAPLLPKNLASLSQLSDKGLRKLADLAGIPQAGAGRRNFLLAASSIPQISISVTTATASALSASLARQNASQHRDFRIHAPKFPKPQTEGWFVLLGDSRKDELYTLKRVGWPTRSGTGGGKPSVKFSLGLPEGGVLEGSDATLLVVSDGYLGLVLRTGVHLQTTQVAPGTWIEKGGEVELGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1A5</accession>
    <name>A0A2T7A1A5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1077136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1A5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1A5"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="133"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="201" mass="22491" checksum="504F6D2B411DBEDE" modified="2018-07-18" version="1">MARTKRTPTRARTPPITCTEIPLKTPNRDAPSGKTLIDLIDTHRPRDPSGAPIPSSTTTPTEDEEEIFGPGMQALCLTVPFCMLLGAFDYLVHLQYRQEVDLRGIIWKVIKSSPPIFSINYAFHSRRNWLSAQALLFAISVLAGCWLVRAVNRTGYYAVMKRAPQVGTLWIWAAVEMSLVPVLGSCLLVGGYSWYFGYSWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1B4</accession>
    <name>A0A2T7A1B4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mtf2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1076728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1B4"/>
    <dbReference type="STRING" id="42251.A0A2T7A1B4"/>
    <dbReference type="OrthoDB" id="2444174at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043837">
        <property type="entry name" value="Mtf2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040009">
        <property type="entry name" value="Mtf2/C5D6.12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39468:SF1">
        <property type="entry name" value="MTF2-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19189">
        <property type="entry name" value="Mtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015781733" description="Mtf2-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Mtf2-like C-terminal" evidence="2">
        <location>
            <begin position="221"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="416" mass="46391" checksum="0BE101F18507C640" modified="2018-07-18" version="1">MSRCRPFALSILAFRPSLAVNSSIHVSTMPLLPLPFLYPSRCVAHYRRESLVEANENLPFSNDRYTSDSESGSDDPWAFLWRTTPPHRPKAPYVAPSYVRDRSQPTSMITEREREIFAQIFESILSEKSSFAPQIRESGRSFPSSALTELFESAVGPLANGNEISFGPKGAINRSSATVGLVKASDNKEYPLAFRVAAARAAGLKSRPRTEEGIEAERHRAKILGNLVDDMRECKSDWELLRWLDKNLFSMVSSQDAKSERKIPSAVYADLLVEGMITFRQSFNDLVGAMSVFERVKGLGAESYVVGCSIGAYNEMLQAKWEAYKDVSKIVELVDEMDLNGVEGSQKTMEILRSIIEEVGQMKGGIMGPGAQSIITDVDTTLLDRLEGYVDVIEERSFEPPERDPLIRDALEYVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1R5</accession>
    <name>A0A2T7A1R5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Folic acid synthesis protein FOL1</fullName>
            <ecNumber evidence="10">2.5.1.15</ecNumber>
            <ecNumber evidence="12">2.7.6.3</ecNumber>
            <ecNumber evidence="11">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Folic acid synthesis protein fol1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B9Z19DRAFT_971139</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the central section; belongs to the HPPK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="10"/>
    <dbReference type="EC" id="2.7.6.3" evidence="12"/>
    <dbReference type="EC" id="4.1.2.25" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1R5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1R5"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00534">
        <property type="entry name" value="DHNA_DHNTPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="25">
        <location>
            <begin position="454"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PUU81667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="718" mass="77574" checksum="7FC1D76438B04B1F" modified="2018-07-18" version="1">MGESPSSEDGNDLIFVRSLNLKATTGVDSWGRKRPQPILLTLWLRSSIALAGSTDHLPYSINYGTVTKVITAHVENDTFNSLEHLAEDIARTALGPDINAGWVKVMVEKPKALLRADAAGIAITRTKNSEGEVLAEGSDRVFVKDLRLVTIIGVNPWEREEKQAVVINLTMHKENNPGKLVEMVEGGKFDPHYNFRSVAKRVTEHVEASDYKTVEAFVTAVAKEACVGCGISKVTVRAEKPSALTFAEGPGVEITRERSFFVLEETAAGVDGKHDVFIALGSNIGDRFRAIKDAVAEVEKKGIKVKKTSSLYQSAPMYYLSQPTFLNGVIQVETTLSPDDLLKALKDIESLLGRSKSIENGPRSIDLDILLYDNLVYETPHLTIPHPKMLEREFVLRPLCDISPNKPHPLTSTAFKHHLSAIPPPPPSTPPLRTFAFLSPHLPPLDPSNPHRKTYIMAILNLTPDSFSDGGQHTHSNIVSTAQELIAAGADILDIGGCSTRPDAEQVSPEEELARVIPAIKSLREAGINTPISIDTYRSAVAKAAVSAGADLINDVSAGTLDKDMLKTAANLAVPICLMHMRGDPSSMMSLKSYPAGVIPGVISELEDRVRAAEEAGVRRWNILLDPGLGFAKDLRQNLELLRGLAEVTSGIGLPWVVGPSRKGFVGKVTGVEVAKERTWGTAGAVAACVAGGADVVRVHDVTGMKKVVDMAGAIWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Y1</accession>
    <name>A0A2T7A1Y1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1099562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Y1"/>
    <dbReference type="STRING" id="42251.A0A2T7A1Y1"/>
    <dbReference type="OrthoDB" id="5362630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="331" mass="38316" checksum="3B4AB05E0741B6A1" modified="2018-07-18" version="1">MHHVLRWSNSPARTVTVSHEEALGITLSLSVYEFIPAYPGQLVYWYKDASGWQSMGTTSYAMKRGINTEILEKYIDDHTWFYVESAFTASPILSEIFRSAWRYSRSEENFMLRDALQLWTATQLLLNGATLHPSSDSLGINPIPSPTCPLANQTPLPRVLANQLDHLIERRIWQLEKQILNELQKRIFGRKREDWLRIFLTLVVLMSALERDSWRLYYWVFHMEDGYAWRHPSPPQRLVEKNNTLAESLAAHFAAISKGLTPFSLDWSREQTVALIGNCEDAPLMLESMERIGRGLRSPDHALRVENVLSHYRESDEKSLDFLYTSKVMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A218</accession>
    <name>A0A2T7A218_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A218"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="162" mass="17644" checksum="EABC097BA945AC0B" modified="2018-07-18" version="1">MPSRNPRPGKHLLSYCDRRSGATIQPVANPPTNPIAVASLHIPGTHASLLTIPPLADILLESSLNIRLTEVFLVKTSEHSSTTCRPQERLEDAGLEFFVPSAQRHPSGERLCFAGVRAATGIAPITLQRSTDEADGPYNEISKHTLSTEVDVFAPRYECYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2A1</accession>
    <name>A0A2T7A2A1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_970619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2A1"/>
    <dbReference type="STRING" id="42251.A0A2T7A2A1"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="13912" checksum="BDC34D4B09F4933D" modified="2018-07-18" version="1" fragment="single">SELARFGIKTTTIEPGIFRTEPLDPHANFIKTNEDKRIEDYREMDETAEALSRDAHGKQLGNPKKGAEVIYEVLTHTGVAQGREVLLVLVLGSDAVSTIQKFARDQADLVESWGEVSSSPDFPQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3J4</accession>
    <name>A0A2T7A3J4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3J4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3J4"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="527" mass="56587" checksum="C34DB413FD917EDE" modified="2018-07-18" version="1">MDGSTSGPAAMVQSKPNAEAMVIPDSSAAGSGAVVAAAAAAVAAGMKKGKGLKSAVEGVEGKREAEPVVEINIEVEATAGDGEPTGKGKEVAKEIEAETPVQIVEFVAEETVSEEKVAEQKGELKPEATTAEEKILEKEELKLELEETVEKEEFKSESVIKEKAIEKVGPELVTEEVVEKAEPGAETILGEKAIAKEEPTTETIPGEKFVENNEPKPEAGEPVETEESKTLKEHTAQPEESEQAPIEKHETIKEPEEKVLEKEPTTETNPQENPTEAKEDDAKAEPEEKVEPKEENIEVEDIAGETELRPEAEVEETKEEMKASESKVEGEETKEDVKASEPEPGKVAIEEAKDIMVPAPAKPSIEEVKVENVTVAREPKVEEVEEKEPTRAGSPKAEVKDIKGEEKPAETAKERALEQPSPTEVKTEKPTKTKAKTAKSPTPKKEPASSKPAASEPVRATPAPTEAPKPTEAPKVAESQRPRSEPTDTPAPDSPQPKEKSAIAVTEEALEKDTNSPTPSPTVRSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3M8</accession>
    <name>A0A2T7A3M8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_968360</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3M8"/>
    <dbReference type="STRING" id="42251.A0A2T7A3M8"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="47"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="888"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="477"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="814"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU82346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="938" mass="101970" checksum="E75FF457857CED2D" modified="2018-07-18" version="1">MSEAQSVTTNGTGSQGPSAGIPDDSNRQSHHPQRPKKTSIQGSTGTWVLGKTIGAGSMGKVKLARKSDGSEQVAVKIVPRQVIQEQGIDPATGQPYPPRHDDSKEVRTAREAAIVTLLDHPYICGMRDVIKTSNHWYMLCEYVNGGQMLDYIISHGRLKEKQARKFGRQIASALDYCHRNSIVHRDLKIENILISKTGDIKIIDFGLSNLFSPRSHLKTFCGSLYFAAPELLQAKQYIGPEVDVWSFGIVLYVLVCGKVPFDDQSMPALHAKIKRGAVDYPQWLTSGIDCRNLLSRMLVTDPRNRASLQEILNHPWLLKGLQGPPENHLPHREPLTLPLDPQVVQGMTGFEFGTSETITAQLSKIIDSEDYQSAVRNAASNTPLASPNPERKKGFGFDFYKRRSSTSSKDTLTNPSSEILTHPLYPDPTNAYNPLISVYYLVREKLEKERRLTNPPVQLLSPVPDGENFAKITIPKQPEAAHTSETSYEFKGESVSTGGRTRPRARTHGDEEVSEAMKKVNLGGASMPPSPVIPQHVKEEAAATKKESTVGGMLRRFSTRRHNSSRSDASRADIKPPPPPTLSLQPPSGPPQADVAAPRKSRSVRRAPGSSRGEPKSAVQAVQPDLLTPPTTSDGGSKRSSKLGRSTSVTEADWRRRYGRNHSGDPPGTSGSERSISARDDGAVSDRGSGTPKATTTRTKSLSHGRGAGTSGSRRGRKDEAIATTPMSNEVPEEDGADAATSVGSADGQNSATLSSDYVKPVFLKGLFSVATTSTKPPVEIRMDIIRVLKQLGVSYTEIRGGFACVHRPSIDLKSVQDNPSSQSPEATNMVTTPSHRRKLSFGGINSNAGSGAGQSSPHKSGGKRNRERADTSYSNSDVSNESMHDGVLGGSLILQFEIYIVKVPLLALHGVQFKSVNKTNTWQYKSLASRILAELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3X9</accession>
    <name>A0A2T7A3X9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1017821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3X9"/>
    <dbReference type="STRING" id="42251.A0A2T7A3X9"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="10472" checksum="C084631AE45BCB18" modified="2018-07-18" version="1">MPTSMEEALKTDPPCLPRACAIQDCLRKNNYNESRCTDLIDALYDCCLELYKRDGPGANRTCCPKEGLLKLKIKQRADGKGSQGAEVHQTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4A8</accession>
    <name>A0A2T7A4A8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1074643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4A8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12787" checksum="B8233B419437AD66" modified="2018-07-18" version="1">MYHLVTVPRQQPVRSHIMRRCRSRNAKSAPDSDPFKPFQSQNVGMFLERGALLQAKNARNRLSRNPDVVSHVAYWFMALASAAIQPEHAFVVNVTLLLLSIIYSLLNSGQSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5M4</accession>
    <name>A0A2T7A5M4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="3 8">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1061345</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5M4"/>
    <dbReference type="STRING" id="42251.A0A2T7A5M4"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="11">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="97"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="544"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU83046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="661" mass="73756" checksum="31EFBE1928233724" modified="2018-07-18" version="1">MSEGGVPVVSEAHNVKTYQVPNKYYEKHPAKPHLTLDEYKAQYRESIENPDKFWGEKARELLHWDIPFQTVRNGSFEHGDVSWFLEGRLNACYNCVDRHAFKHPERPAIIYEADEPSEGRIITYGELLREVCKLAFVLRQMGVRKGDTVAIYMPMIPEALVAFLAIVRIGAVHSVVFAGFSAESLRDRVLDARSKVVITTDEGKRGGKVIGTKRIVDDALKQCPEVKNVLVYRRTGSEVPWTKGRDYWWHEEVNKYPGYCAPTLMDSEDPLFLLYTSGSTGKPKGVVHTTAGYLLGAAMTGKYTFDLHPGDKMGTAGDIGWITGHTYVVYAPLLLGVSTLVFEGTPAYPEFSRYWDIIEKHGITQFYVAPTALRLLKRAGDHHINKQMKTLRVLGSVGEPIAEDVWKWYHQKVGHEECHVVDTYWQTETGSHAIAPMAGVTPTKPGSATLPFFGIEPAILDPVSGDELHGNDVEGVLAIKKPWPSMARTVWGSHQRFMEAYLNDYKGYYFTGDGAGRDHEGYYWIRGRVDDVVNVSGHRLSTAEVEAALIHHEAVAEAAVVGIADELTGQTVNAFVSLKDNFENTSEMRKSLTIQVRKSIGPFAAPKAVYIVNDLPKTRSGKIMRRILRKILSGEEDQLGDTSTLSDPSVVSAIIKTVQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Q5</accession>
    <name>A0A2T7A5Q5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Q5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015452120" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9504" checksum="1C194A9079926988" modified="2018-07-18" version="1">MLQVFWPLRGICSVFLPHIWLQDIMVTAAASDQKTDWEGPFILMKMCVVAWIEHPRPCSLFFSSASTCTPKPPQCTDRYCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5T8</accession>
    <name>A0A2T7A5T8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1189971</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5T8"/>
    <dbReference type="STRING" id="42251.A0A2T7A5T8"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="90"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="383"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU83035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="488" mass="55104" checksum="4D9E1E937EE00A22" modified="2018-07-18" version="1">MRLLFSSRNLLAASGTSGGFSGVIRARGITQFRSRRRKYSTTEEPPSPPTTKLEGRHYPIDEWTNLPSHISSALPRKLHLQPSHPLSITRRLIESRFPGPTYQYHNDLSPVVSVHQNFDSLGFPIDHPGRSRTDTYYVNKDIVLRTHTSAHQADTFRSGTSDGFLISADVYRRDAIDRSHYPVFHQMEGARMWSREECKARGGIAAVIKEEVEGMPKHEINVEDPNPPFHEKRNPLQVEHTPEEARAVGAHLKLCLEHVVAEVFGQARAAAAAAGGASAEGASEEPLRVRWVEAYFPFTSPSWELEVYWQGNWLELLGCGVVQQSLPKSAGIPDKIGWAFGVGLERVAMLLFGIPDIRLFWSLDQRFLEQFKEGEISRFVPFSKFPPCYKDVAFWLPSSSSAAGGQIPFHENDMMEIVRNVAGDLVEDVKLIDEFTHPKTGRKSLCFRINYRSLERTLKNDEVNSLQQTVQRVLVEEFGAEVRERNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5U3</accession>
    <name>A0A2T7A5U3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Surfeit locus protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_211537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5U3"/>
    <dbReference type="STRING" id="42251.A0A2T7A5U3"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="14275" checksum="FEC1328297C6BFCD" modified="2018-07-18" version="1">MAPEEQAKIEEKELWGKALGAAAGKKIRGDEQLLKKSLKRQEQVKMKSEREWKERIENVATSKAMKQKKREDNLAARREQKANKSGKKVGGKQGIQMKKKKGPRPGFQGTMKSNHSGGGGGHPKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A600</accession>
    <name>A0A2T7A600_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1073157</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
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        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
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        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="127"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="333"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU83167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="571" mass="62877" checksum="EBB8F26983F9B3B2" modified="2018-07-18" version="1">MGGLINSAKKRKRVEKEQGEKLLKTSPSIGTSNSSGVKKAKNSSKPQTKSPKKSPRAQPRSKQQTKGQGGLNSDTDEDGDVQGSGGEDDTSTQDPQVFTDLKLSTEILNSISSMGLTELTSIQRKTMPLLLTGKDVIALSKPGSGKTLAALASIISLVTSRNVKSRNGTIAIVLTPTRESALRLLGAASELLSNASQTLGIVTDGSNIRPEIERLANGVNILIATPRRLLEHLNTTPAFVIQNLKNLVIDDAERIAKTAGIQDILTHINKVLPKKRSTALFSAETIDETVVGILHFRSPHRVQADDQTEQQSEPVEGQVQGYVLIEPEKRFLLLHSFLKKFSRKKIIVVFSSTSAARNYAELLSILELKVCQVHAKQTTQQRASNHSKFKVAKEGVLICTDAMFRGHETPAVDWIIQYDPPEDPQEYISRLSRPVGGRNVIFLLPDERAFVGYLKDVKVEAEEFEFSSKQLVNIQSQLEKLVSKDYQLHCLAKDAFRSYLKNYALHTLSSVFDYSKLDVAKAAKSFGFDTPPRVDMHPDEAKDRNKGRMTYAPPKPGVFPGKVIKRKATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Z9</accession>
    <name>A0A2T7A6Z9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1072555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Z9"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Z9"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="284" mass="32727" checksum="97034AA26F7F5E02" modified="2018-07-18" version="1">MPRSHSRSRSQSPPRRQNRRSHDSRSDRRQQDDRSTRDSNRERRYRRDQEEEDERPPRRRDDSGGRHSERRRRRDDRDRGYVEKQRVEARDSKDISRGLPSSATPDERLARRAVASTSESGTLEPPKDREEANFNTTGLLAAASNTTNGVVLKYSEPSEARKPPGSQRWRLFVFKDKDIIDTINLNSSSCWLIGRDRAVVDLPVDHPSCSKQHAVVQFRFVTKTDEFGDKESGVRPYLLDLESANGTGVAGKRIPESRYVELKDGDLITFGLSTREYVLMLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A740</accession>
    <name>A0A2T7A740_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A740"/>
    <dbReference type="STRING" id="42251.A0A2T7A740"/>
    <dbReference type="OrthoDB" id="5426191at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="348" mass="38246" checksum="7E99B31215EAD98B" modified="2018-07-18" version="1">MAAIQAGSLSPIMNLADHPPQYINPNAPVLSSLILYIVRVPGSQDLFLTTLHPLQSTVTAEDINACLYYIHIEPVVNTSSIASSTLSPPLPRPSSHRRWSSQSITGSRHSSRSPARPIPTMTIVRRDLATGAQWNVARISSPSSAEEDVERILVDIMTAGYQRFVEPAMDWDEHVSVGFRREMWIEGTGFWSRVKNMGHRRGRSTSTSSDSREKASAAAAPAGEKTKKRGYVFDALWSPGKGEERGRCGFKDEAGGKFLKCKYYPPTHPSKSSLLSVLEFKPPSTTVLSAAPGREAPEVITSSKSKLGMLVCHSDGIYMMDLLVAANMAVFWKRWESWASERSALSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Z7</accession>
    <name>A0A2T7A7Z7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Z7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7182" checksum="FD1EEE932F7F5FF1" modified="2018-07-18" version="1">MVGVENVEEWSKRRNGWGEGGGRFEVENVEEWLRGGTVGVENVEEWSKRRNGWSGEMDGAAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8F9</accession>
    <name>A0A2T7A8F9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1071289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8F9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="59" mass="6627" checksum="80830F598FDD08F2" modified="2018-07-18" version="1">MREYSKVSKWLLAGLVGPRIKQKISLELRYLTSGLLHLNSSCATAGVIVPLPSWQLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8M3</accession>
    <name>A0A2T7A8M3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1189152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8M3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17441" checksum="30E3F07DF97E33C0" modified="2018-07-18" version="1">MVTGCRAMRVCRRCHATRTLLSNVCRRLIKMFVPWVSQVDIKTSHLAPDSIEQVKFGIGGPIKSSFFLKIVMFFVMAMAREGQLDSSPDFTHASNDLRVMPSHQRQFSTCRPGATAASPSFSKETPGQYHEKPPSRGQQQYTPRCSVAELPEAAGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8U6</accession>
    <name>A0A2T7A8U6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_895169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8U6"/>
    <dbReference type="STRING" id="42251.A0A2T7A8U6"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9643" checksum="34BE4DE7269902E3" modified="2018-07-18" version="1" fragment="single">PSLLSAPDQDGNTPLHEAAISGHSSMLQALVTRFTQDRAYNNEINKKNHSGNTALHLAFQFDHMEIVELLVKKGADTTIKNNAQMTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8U7</accession>
    <name>A0A2T7A8U7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_961178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8U7"/>
    <dbReference type="OrthoDB" id="9989103at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
        <property type="term" value="P:virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009013">
        <property type="entry name" value="Attachment_protein_shaft_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771">
        <property type="entry name" value="LD27203P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47771:SF14">
        <property type="entry name" value="RH73259P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51225">
        <property type="entry name" value="Fibre shaft of virus attachment proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="237" mass="25112" checksum="707892598E116BC1" modified="2018-07-18" version="1">MEPVVVPVRMPVRMPARKPVPKPVPKPVPKPVPKPVPKPVPKPVPKPVPKPVPKPVPKPVPKPVPKPVREPVREPPADSLTLKLANGLTLKPADSLTLKPADSLTLKPADGLTPEPANSPTLKLADSLTLKPANSLTLKPADGLTLKPADSLSPKPTDILTPNPADGLTPEPSDNPPPEPAYRLTPNPAHGLPPEPAYSLAPKLAYSFSLKSAYSFTPKPAYDLTPKPAYSFCLKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9A8</accession>
    <name>A0A2T7A9A8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran GTPase activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_960508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9A8"/>
    <dbReference type="STRING" id="42251.A0A2T7A9A8"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU84318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="43804" checksum="6560D75BA3D39952" modified="2018-07-18" version="1">MNNKVFILKPSDGKPLKLDTAADIEPHIASLRGNETVEEIRLSGHTFGIEACKALAEVLKTNRNLQAFNAADIFTGRLISEIPDALAALLSALLTLEYLHTVDLSDNAFGGRLADTLRDFYSRAGPLRHLLLNNNGLGPTGGIIVANSIRDLAALKASSPAYPPLETIVCGRNRLENGSMEAWAEAYAAHKSLKTVKMVQNGIRQEGINALLRNGLSKNHELQTLDLQDNTFTITGAQALAAVVTNWNDLLELGIGDCLLSARGGVLLGEALAQGKNKALKTIRLQYNEIDIKGVEAIKRAIHPALPKLQRLELNGNKFSEEELVVEQMREIFEHRGFGELDSLSDMEEETDEEDEGGEDEDDDETEAVIKRAEEAENANVPQEKDEKVDALADLLDGAKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9T1</accession>
    <name>A0A2T6Z9T1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinetochore Sim4 complex subunit Fta4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1097708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000620">
        <property type="protein sequence ID" value="PUU72243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9T1"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9T1"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="239" mass="27187" checksum="E6FB8936E2E882D6" modified="2018-07-18" version="1">MATGNSIYDIKKGFLSSQLRILDGALKPKENWQEKLPEGEHGDLSEGVLNQVLYKLNVVAKRHQKLVYSSQALRHVAEQIDDLYQKKDDSEEGITREDDVLRRGANLKDPQNIDLLPESYPAEEKDSEEDLEEYQTLKAKLANHSAALQAQRQRHAYYSQLKSLIAPFASPQQSVQPNLVTKDGPLAAELERTRLLAAKLAYQIEKSKFPNTDRMHEDDDDEMEESVGDRLRMILEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9U9</accession>
    <name>A0A2T6Z9U9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1011355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000607">
        <property type="protein sequence ID" value="PUU72267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9U9"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12480" checksum="71DD2C23D67D915B" modified="2018-07-18" version="1" fragment="single">ISVKPHSLEYNTEVTTAILVNDILAVGGFLDIEILFVESMVTYVVAADPKLLLFDLILDSISKLQKLFITAHSLSIVPLKYPYYKGTAKLYFRLDKDCQCTAILTCACVIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9V5</accession>
    <name>A0A2T6Z9V5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 16">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 16">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 16">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B9Z19DRAFT_1011323</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 16"/>
    <dbReference type="EMBL" id="NESQ01000604">
        <property type="protein sequence ID" value="PUU72278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9V5"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9V5"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="18">
        <location>
            <begin position="44"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="19">
        <location>
            <begin position="242"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="17">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PUU72278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="386" mass="45401" checksum="B281BDF95B61F289" modified="2018-07-18" version="1">MPSRPSSVPSMPGIKADHNLAQMLRAEIGEMLGRGRNTSFPGAQPVSFARKHLDELKRQDYYLCEKSDGIRCLLYFTYDGDREVHYLIDRKNDYYFVPHLHFPMPDDPTFRRYHRETLVDGELVLDDVGGPKPLLRYLIFDCLILDNKHQMSRTLDKRLAYFREYVYVPYKNLIKQFPQALDDFPFQVEFKKMEFSYAIQMMFQDILPNLPHGNDGLIFTCRTSPYKFGTDQNILKWKPAEENSIDFRLNLEFPLIAREDLEDEDEDESDTDSMAPDYDAMPKFNLSVFMGDGRYEKWAEMYVTPQEWDEFKSMGKPLDEEIVECAMDKQERWRFLRLRTDKKDGNHISTVNSVIESIRDGVGKEDLMAAAKEIRDAWKARLPRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA88</accession>
    <name>A0A2T6ZA88_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1137749</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000550">
        <property type="protein sequence ID" value="PUU72395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA88"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="569" mass="63581" checksum="91615E2DAFDE7C1E" modified="2018-07-18" version="1">MLVTILASTVSQVRAIVITCVATFLVLCTFSDICHFTPTPGSSSVEYPPIDTLAPSQPVEQPVSKLEDEVECKSEEVPASEDVIPHGVSVFMPSNFVEHLILPRMSNEGTTWLTYLSEDLNIITKTYLIDPDKSNIAPGTLTVLVNKGREAQAYLTYIIEHYDLPLGTHFLREKLGVLGKLGCTIYLIGGVIIVLHAPPDEDIQTIDEILNYAIQPGFLAYVAIVSAFSSIMIYKVSPKVTPLYYVTFTTATLIASFILFRGFNSTDPLNTISLVCGFLAIFGGVYPLNLSRPDPDGHLLAANGSASYGERVPTDGITGLQVRRSMQLRRSDVGGSRSSIGARLLERHLDEEAAVGLTDLAEDDDSDSDDIAIFTHAHSTAWHSNDLQLSSTPMMLLELNYRRIMEHGYMNLRCHWNPGCPDWIKPNATEYNDLKKEELVMHEPFKELFLQEVARYGVPDMIGTPCCARFAVTRSRITQHAKERYISWRKWHFIFASPSLERNADKAAEEGVGRKESEEESWRQEGIKQWKRELKNMGREGETEVQLARRRGSDAKMRRGEVGELEFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAC4</accession>
    <name>A0A2T6ZAC4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000541">
        <property type="protein sequence ID" value="PUU72419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAC4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="19903" checksum="8010E1631EE9649A" modified="2018-07-18" version="1">MALQRPLKGAPYARFLLIWGVWKVLTSRPDSFGVRNAIGKPFSNGVLQYPMYPSLKGRLHTTMFYGVTVFSEASWGIRNVIIKPVDDGVLLYPICSPPKGYLHMSTPYGATELLGVRHAIMKPFYDGVLRHPICPAPKGYPHTSIFHGATESSEGRVHRLGVFGYLESADFEAIFWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAE9</accession>
    <name>A0A2T6ZAE9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1097242</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000532">
        <property type="protein sequence ID" value="PUU72455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAE9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAE9"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000965">
        <property type="entry name" value="Autophagy-like protein 18 Atg18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU72455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="422" mass="45443" checksum="A0A52B69662CBBAE" modified="2018-07-18" version="1">MNFVTFNQDFSCLAVGTRNGYRIYNCDPFGKVYEQKEGGDVSIIEMLFSTSLVALILSPRRLVITNTKRQSTICELTFPTSILAVKLNRKRLIVVLEEQIYVYDISNMKLLHTIETSPNPTAICALSPSSEKCYIAYPRPTNSSTSPFSPPSHAPPGVNAPPAASGDVLLFDAIKLEAVNVIEAHKAPLANVALNSEGSLLATASDKGTIIRVFSIPSAQKLYQFRRGTYPSRIFSIAFNLMSTLLCVSSATETVHIFRLGGLNPQESSSGSFRANDSDAGGSPTGSIASSPSNHAGAAGGGFDHYVESKRRSGSGTFGSMIRRSSQQIGRTIAGAAGGYLPHAVTEMWEPARDFAFVKLPNAGLKSVVALSSTSPQIMVVTSDGYFFVHNVDMERGGECVLTKQYSLLDSSEKMGQSLMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAL3</accession>
    <name>A0A2T6ZAL3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1009316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000511">
        <property type="protein sequence ID" value="PUU72542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAL3"/>
    <dbReference type="OrthoDB" id="5403175at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="25042" checksum="555C97AD8E1DBA32" modified="2018-07-18" version="1">MSNPIYAYREYLHLLPHLFFVKVEKQAPGEACIACDSTLTSQLYECNTCTLRLCEPCRDRIVDRYHMGSLTKLIENVASWKLRYRSPIGIENQQQQQLHPQYQQEQIGGGADMNHHAVIMMMQDGYGQQQLQHQGQLQIHHQGQEFQQIHQQRQQEDMEEQQIMLQMDGGSRTRRKFLEMMQKIQSEIDMEAELENMDDMLGRMRRRGPMGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAS6</accession>
    <name>A0A2T6ZAS6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000509">
        <property type="protein sequence ID" value="PUU72546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAS6"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="299" mass="33981" checksum="B7916E68F01C399C" modified="2018-07-18" version="1">MVQICSSMDSPGTASGYPINPRYSMTSEFHTDSNGAPTTCPTSPAMSCPSTIHRHPLSPHNALSQNPYCIEATPTLTARGPSTTPYPINFLQSPQQLLEQREARWNERIQTRITELEHNFSLKSQKHQEECHRHCDEWYKRCENQAREIQEKSDENATLIAEVLHGKIEKIKLMENFNIRGALEHMVYHAKLIKEIRADCPAGIQEGLNELAKTPEFTRVLGEEVASRGLTLEAVIRCIALIYNKTFLHAHGNDDIITLYNGDYTANEVAVLATFLKVQSARLYGLEWKEEKRKGHIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB67</accession>
    <name>A0A2T6ZB67_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_628977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000474">
        <property type="protein sequence ID" value="PUU72742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB67"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="16287" checksum="B9AC37EFDA627948" modified="2018-07-18" version="1">MSPLCRSLFSGSLLGTGVTNRICRKGKKTKKKGWVTHCGDGSPSSCTPVQDSTRVQFCIPHRIALGEGNTDWWWWARPGTLTRLAWPFGWVIMDVGRCVGVVGTTLRVYYLCLTHFELNTFCTFVSSLGEFCGYKIFHLHPPIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCE6</accession>
    <name>A0A2T6ZCE6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1058480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000409">
        <property type="protein sequence ID" value="PUU73153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCE6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCE6"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="444" mass="48172" checksum="D2E1043C5CEBB95A" modified="2018-07-18" version="1">MSGLQPVLPSNQAPSTFEYGGDEISAIVLDPGTAWIRAGFAGEDTPKSVIPSDYGVLEEAGENGGKKYFIGDNDVHSIRPGMEVKNPMSDGIVADWEAATILWREAITPRLTTALSEHPLLMTEPSWNPPKNREKTIEVAFEDFDVPAFYLAKAGVCAGFASGKSTGLVIDVGASNISVTPIHDGLVLRKGCVRSPLGGEFLSNQIRAYFESANIPLSAHYQVLSKTAVEVGKPAEAIYRTFAPGEEPTESYKRFQEERVLTEFKECTAQVWVGPGPLPGNNNPPLEAAHAILSPGGRTFEFPDGYNLVFNSERFRITEGIFHPPSMLTAPNPDPQTTPGLNQLIANAMKDIDVELRQTILNSIVITGAGSLLYGFTDRVNAEIAAAFPAPRVRIMAAGNSVERRYASWLGGSILASLGAFHQLWVSKKEYEEHGPNIVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCL4</accession>
    <name>A0A2T6ZCL4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Six-hairpin glycosidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000397">
        <property type="protein sequence ID" value="PUU73235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCL4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCL4"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015499924" description="Six-hairpin glycosidase-like protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58978" checksum="4781B1450C384E7B" modified="2018-07-18" version="1">MIGAATLLLSFLLLTGESEASRQDALYRSQQQQSPYRRQACPDYRDYATRLHPPYSTGKYRLPFQRPVKECRLYSSPAVESLIEEMNARINDKDLARLFENCFPNTLDTTVRWHLNADKVADKQSFIVTGDINAQWLRDSTNQLAQYQLLAKDDEALRNLILGAINTQVDFVLRSPYCNAFQPPKASGLAPTSNGQDDTVHPVYDNTVVFECKYEIDSLASFLSLGNQYYNHTGDLSFVGEKWLSAVDNVMALIEEQQVPSFSNTGSVQDQVYTFQRRTSLGTETLNLGGIGNPINHNTSLVRSAFRPSDDAAIMQFFIPGNAMLAVELKRTAEILKKVKQIELANFVRKKGEEIEAGVWKHGVITHPVFGKVFAYEVDGYGSHIIMDDANLPSLLALPVLGFVDVKNQTYQNTRKMVLSREGNPYFLTGTEFKGIGGPHIGITHAWPISLLIEILTTDDDDEILALLAMVLKASPLGLVHESVNVRRVKDYTRSWFAWANSLFAQTILDLARRKPQVLFDVNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCV7</accession>
    <name>A0A2T6ZCV7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1095530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion inner membrane</location>
            <topology evidence="2 8">Peripheral membrane protein</topology>
            <orientation evidence="2 8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ATP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000397">
        <property type="protein sequence ID" value="PUU73244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCV7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCV7"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02410">
        <property type="entry name" value="RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="750" mass="83933" checksum="1A137E343A26E113" modified="2018-07-18" version="1">MIATGQVSRCVNYRLAIFNSPISIFATQVRLSVWAGRGRLRTEVLGGQRAFRTSPVRFQEREGIEGYNTTESEEPTIIDPTRVSLETPRAPQPTTPAPPETSDSKEEPVPWYLRAKTPISKFHPLAERQVLPPLPEDPPPALQAVLTQLSVGEGIDYLKVLDLRALDPPPALGEDIVMIIGTARSGRQLHMCSDRMCRWLRKEFGMRPFADGLVGRGELKLQERRARRRGKLTTAQSGIEEAAGWVCITAGSQGLVIQLFTREKREEVDLESLWGKELERDSKKREAEQRVAEGKEQGTFGAFGRGLSTRFPVPGSVQTRAFHSSSQQPSQAATEPPAESLVRFAKDCINVDTHVRKGHYWRLVPRVSEAFDPDADLKNAAYLTEAHINHLRNKFRGNNYSGKITKGCGLLGQGVQDRTSTQFLQSYFRYFPKHPAPVHLRLHLQFLIETNRIKPKEYPLSEATSFLKTLPAPVPAELYYMCMRAIADSPEYRSYELPASEAATLRLSLIQDLAEHFDPTSTLSQHIPEFQFCKFRALAHNAVTAVLLAAKTVCSTKRVEAGKEADGAFKWFKIRVGTYPLDPRLIEIERESIEQKGHSYAIREYIEQAMAAYVAADHWTALWNRWKNLKYMSVGRDQGFYELLIGLVVLGAKQKEGVYAARHIWNDMERETPPVLMTAGIAKGLLAVVQLAERGSNVSGEFAGLETRCNGYLERWHKWRAEKGLVEEESAAANAVREGKAGGGNGSAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCW6</accession>
    <name>A0A2T6ZCW6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L34e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1058106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000387">
        <property type="protein sequence ID" value="PUU73332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCW6"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="134" mass="15170" checksum="DA6C36A6C079DD23" modified="2018-07-18" version="1">MASTRLTYRRRNPYNTRSNRVRVIKTPGGKLRYLHIKKRGSPPKCGDCGIKLPGVPALRPREYSQVSKPTKTVQRAYGGSRCANCVKDRVVRAFLIEEQKIVKKVIILPLSSRLTNMLIRIGVQVLKEAAAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD49</accession>
    <name>A0A2T6ZD49_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1163088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000377">
        <property type="protein sequence ID" value="PUU73420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD49"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="264" mass="30024" checksum="63671D9650D6CF60" modified="2018-07-18" version="1">MERPDISEFVHPTLSNQCALGTRMVVLQAKNQKGVYVHKALIKDEAGGCTWSCFPSTTVRSFVEYLYQGDYNPPPITSTYLGGWDKSVEDFSDDYKEIFLTHAQLFILSRYRNELSLANLCLERLEEAIVEAQSDSVESLFVRNMRTLIEYSYSPHCYGLGDGVWEELQKAVCRFLVSQKGWLLEKPGSGLVGEDSQLTKDLLTMFINLSIDTDKLRMEAERKCEALKTELAQSKSAKKKKRQALTTSISVKKCEELNAYRMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDV1</accession>
    <name>A0A2T6ZDV1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1111068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(34) in tRNA(Ile2) + L-lysine + ATP = lysidine(34) in tRNA(Ile2) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDV1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDV1"/>
    <dbReference type="OrthoDB" id="434144at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032267">
        <property type="term" value="F:tRNA(Ile)-lysidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033:SF1">
        <property type="entry name" value="TRNA(ILE)-LYSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="481" mass="53346" checksum="228EC54676769986" modified="2018-07-18" version="1">MVRLNSISLSEYAEFLHRLWPGAGLPARLGIALSGGVDSMALAYLTSCLFSSHNKPPSAIHAFVVDHKARPESTAEARSVAQLVKETYGFTAHVLPLTWTLSPIDLLNGFETRARIARYQAIGRSCVENQVEKLLLAHHADDQAETVLMRLLAGSKMQGLAGMRAVARIPECGDVFGAERVVVGRPLLGIEKGRLRATCLENKVCWFEDKTNQDATLTRRNAVRKLLSASPPRLPRALQGPSLVALAQRAEARSKSARDQASVVLNEDCNLFFDPATGSLQLQLPPEIRGIQPRVLQNLLAQVVETISPLPRVETQSLQTAVKNILSIQRKPFTAAGLKWTYRLDKTLFLQRQNYTSRSRELCRMIFINNSPGWTPRHLWDGRWWIRLFIPTPSHPAISIQPMEEQDIGPLREKAAQLNMAKQLGQVLKEKLKGEMRYVIPTVYCRGEVLGLPSVGLWLGGGSVEEGVKCEVMFRGRGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDZ3</accession>
    <name>A0A2T6ZDZ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000352">
        <property type="protein sequence ID" value="PUU73702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDZ3"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="385" mass="43741" checksum="579D2BF5C697E982" modified="2018-07-18" version="1">MALAPSSIGGSDRSSGHSSSPPSSVTPASRPHSAGGAAIFPTAPAIGHPSKIPKHLQSLCDVQTSDLDLTPHEKKVIAYLRAKTAWSLRYPAEDLPSPQQLLEQEEFKRYLRFQEDTTEEEDKFYFQSKEGHPSTTQKHPQSPYDVQTSALNKPPHEKNATSNLTARGTSSRSYPIKVLPSTQQLLEQQNAKWYQRLTDYASEYREEYHRQSLEYLEELYRRSDEWHAKSDEKNKEILKLSVELERLTCDTLYGKTEVMKLEENFNVKGALEHMVYYAKIMKRIGTDCPRGIQAGLNELAKAPEFTKVLHDEVASRGLELKAVTSCIASVYNKVLRRARGNDYIITLYKEDYTANEGAVLAAFLRMQSEWSYGLKWREEANYPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEV0</accession>
    <name>A0A2T6ZEV0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_489922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000327">
        <property type="protein sequence ID" value="PUU74015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEV0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="14174" checksum="5B939D05D55B2C3F" modified="2018-07-18" version="1">MGWIRSPVPFFFSFYSLFFPSCFITGSECSFLEIFYSFLLFSFHSFLYYFIILYFVYGKRGAFYVMWKRKEESCFIITVSFVSRFAYGFASWYPFLRRVVFVAIPKPPLLGGGFFFSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEX0</accession>
    <name>A0A2T6ZEX0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_489612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000326">
        <property type="protein sequence ID" value="PUU74048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEX0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8463" checksum="C989D91EF6541CEE" modified="2018-07-18" version="1">MPMFTAQAMLRTAAKLKLIELPAVLPILIRPVPDIIVDKCDLSHVLYSGLTRAIVDGHFYTKNKGFQSIRTRPPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEY8</accession>
    <name>A0A2T6ZEY8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1093765</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000325">
        <property type="protein sequence ID" value="PUU74055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEY8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEY8"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU74055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="554" mass="63538" checksum="F432DB2437EC51BF" modified="2018-07-18" version="1">MARLAAKMLSRRQVEGLIAEGKTVFIFDGNVVRADAWLKFHPGGDKTILHMVGRDATDEVNALHSVETRARMRSFIIGKVQQPWESFTPPLHGGKFRPYIEGEEDEELSEPECPRSREARSSSSSSVSSEGNSFLLDPSLRRRHQGSAVASSSSSMTSVSVHDETSMEELTRRGVEYDLAAYPALDQETQGKIVDLYRELDKQVRAAGLYDCNYVRYMREAMRYLTYLSISLIFLHYGWYKMSAFFLGVFWHQITFTAHDAGHMGITHHFHIDTCIGIFIADFCGGLSLGWWKRSHNVHHIVTNDPEHDPDIEHLPFFAVSHRFFSNLYSTYYDRVMQFDAAARVLVRFQNYLYYPILCFGRFNLYRLSWEYLILGLGPSKGIAAYQRWLEITGMAVFWYWFGYQLLYKSIPTNWDRFLFVMISHAVTMPLHVQITLSHFAMSTADLGVKESFAQRMLRTTMDVDCPRWLDFVHGGLQFQAIHHLFPRIPRHNLRTAQKLVMEFCKKSGVPYALYGFYDGNKKVVGHLGEVGIQAKILAECQAAIINKGDPGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH27</accession>
    <name>A0A2T6ZH27_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_998399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH27"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH27"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="618" mass="68497" checksum="D22961CC2802F31D" modified="2018-07-18" version="1">MSVMDAATELKHLKFTPRTSAWKHMQRFERLCSLAYPRATDAGKWSLFVKTIDTTNVWGTGRGMTPGRWLMDLSEDWLRKNPHCSQPDCTDCKHDSMSFDYLRTAFLDRWGATNTSPHGNLRQPMRSHSMPPPSESDGDPAEMITPSDIVSNALIPRGGSSHYNPPAAPTPPNEPVSERERLVQETKTSIAINPAGNGGGQIVLQITDNNKPRKRKKEIKATIDTPPPQHSMHEGSLPDSPRDRDYHDRDYHPDDRDAYRSDRDERDHRIPRDHRTQHHDRERSRHRDGVHVIEAEPPVLELIRQPSPQSDGRHDNSQALVEVASSEVDESTVTGDALLTAPSQPVLRPRLLEGKICAITGASRGIGRAIALGFAKEGANIIAHYWGTKSDPANEEIVSLCVEIRSMGQGCTIVFGDISDPRTSDNIVKRAVETYGRLDVAVGNAGMCWYREFLDVTPELLRRHVDVNLNGNFYFVQACARQFKEQFHAMPIEPRPDPIPDYSIIFISSASALSGNGHQSHYNPTSAGVLSLMQSTTISLGPYGVRCNALLPGVVQTKMNREELQDMEKRGRLEKKVPLGRLGVPSDVVGPAVWLASDGAKYVSGAQITVDGGAFVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH98</accession>
    <name>A0A2T6ZH98_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000268">
        <property type="protein sequence ID" value="PUU74849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH98"/>
    <dbReference type="OrthoDB" id="5430981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="750" mass="83517" checksum="94CC81AB41EE5F0B" modified="2018-07-18" version="1">MPEGKFWKQLVPERRHLTELVLSTTTSPSSSHLSLSIPNTTANRINFSSSLPTTPTPQISVIWPQFDEARSQIHNSPSSSSSERVSFQFPSSPLPLPISFTTAPPEPVDKMDSALMADLGLKPFAFAGTSRDNVEQFPKGIELALTTDEKKNTWSDELKVYFLFQNIKAGSPAERFVRRLDGETTGSYGKVCEVLKERFGNDDELAEERRRAEESFLELQQHRDNEHLVATQFVHRLDSHELRIHVMTSLGSHPKMNDTIIKVRHTASMLDDASPIAQQRESGFDHGTSSDDDDSESDDDDSYHGKCARRRRRERARQSKTTKGLKAQWESEEAQNIRLELRELKKLIQKTQESSGNSPQPSSSSATRQLVQQTLPFVDTYAVNNLLAPPPPPMFGSMLLGQDRGQASSGVPFNYPPYRQLQLWNMNGNQPNAGYWHVLVGHWRTECPLLAYPNSDATNLPSGNNFSSTLLNILQNTQRQLQPPQQPPPTANRGVTHNQASTSEANGGLSRVVGTVAGIEIGSCSSAMDGMAVNITAKGKKILAENEFVKGLLQEGATDSTNRNNVGDTMGGERARPHSEVAESSGTAGEPVQQRLWHTYRQPGDDIKQWKLPKHQGRRPPIRLMVDQMPFDFIGGLRDRLVTGLTWGHFFDLAPEAKRARLNGRVFELKYILMDAGSVVNMSPISILQAIGASLFRTWEITIRTATSILVEIEFYTDLEIEVASVTTCLRVYAIPAICELNYGLLQSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHL5</accession>
    <name>A0A2T6ZHL5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1132151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHL5"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="533" mass="59881" checksum="CD178A51AB91EB79" modified="2018-07-18" version="1">MESPRDEPEHRYRPTRQLPYTLNERARVSIEETLYPSAVEFLNSISIPGTSTPSQAPHPAFIPPSTFQRCITTLIAHPYYTTQVSKNEPFSTAPGNAYLLLRRMLRLVGPLNAEFSKAWEFNKNARAGRQVRGKTRGRGGKGKGPDPTDGLSTDDDLNGDFATTESLFSVADDFWSIAGWAFTCSISHPKRWEWWKLVLDLMMDVVEQDWMDRLESKEVTGDKSALDGALFVKFLPQDTGSAGCKKIVRAIMTCAEEKSFNEWKEIWENELSTKRPRKIRVGTQDTTFMGDEEDDEEDKDMKGEPDGDGDTEMQDADSSGVEVEGLPSVSEAYGGIESVDLRQRLLSMLSTVCIAGCYVPTEDLFYEFTETFIRLSLPHFHFFTSTLLDTTTEYKCTLNQLILSTIISTRAPVYNGRLTATALVNNYLPFEAKTTHLADNARVAILLETLTRLLINAKLLEYSQDLQAAVAKGIKARASKVPKSFAKPGTQKYLLDRETRGIWSAAETRLKGLTEILRIQKEEEEIQDSSLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHQ9</accession>
    <name>A0A2T6ZHQ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Emopamil binding protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1054799</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000255">
        <property type="protein sequence ID" value="PUU75025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHQ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHQ9"/>
    <dbReference type="OrthoDB" id="58557at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000247">
        <property type="term" value="F:C-8 sterol isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF0">
        <property type="entry name" value="3-BETA-HYDROXYSTEROID-DELTA(8),DELTA(7)-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="7" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="15">
        <location>
            <begin position="50"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU75025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="25759" checksum="518C5DF0E05149B8" modified="2018-07-18" version="1">MHPYSPSHLLLPNYVRNNVSALGLCSVMGSLIITVVGSTWMFARTGLSTTDKAIVCWFLISGLLHLLFEGYFLVYHATLLSRIDLPAQLWKEYAISDSRYLSEDTFVLAIERITVFLWGPLCLLAAAATAKSSYNRHALQMLGSTAHIYGCLLYIVTSWEEGHRHSRPEPYYFWLYFVGFNAPWIVIPSILIYRSFAQIAGAMKSAQELEENKASALVIADISLVPECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIL4</accession>
    <name>A0A2T6ZIL4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIL4"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32756" checksum="03C5279C08330AC0" modified="2018-07-18" version="1">MARIHTSRTTPTLLSGVELEVTGRACEPKLRCNPTTPLTVEFYLRYPHSSLHYKQTKAKPQESSPPPLKPRMDSISFRTAYSSGVDTYYTQNASTYRNPHESGITKSLRAILEVIIPPNHPPPVRIFDLSSGSGEATLAAIRFLQTHRPTLASSAVINACDPYTHELYTTRTGLPCGKESFRDILLEGELKGGKHDIVICSFALHLCPKGEIWGLLYALSLCSRWFVVLAPGKGPEVGADTGWERKGKEIMVERVRGRVYRSLNFADDREEGGKREDGKTNKEKGVEGTIEPGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ58</accession>
    <name>A0A2T6ZJ58_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_994233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ58"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ58"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="369" mass="42426" checksum="545168E765E9DE91" modified="2018-07-18" version="1">MSVCTLSASSSIRALGAIRFNVIRPIALQGLRTRAIPNKSSTEGVEGAGSAEGAKKNRLKMRTIETMPFQTFQLALDIINKDRQEKLERITQERETMKKLIKHKGLTHADRRIVSMKQQIEKWQLYADANNPRVKYNFDCGIIGMNKPIYLHLLNKKWRQRNRPILMQRLETMHVIPDVLPAINPIADVQVHFKGRKVQSGLLLDSLMVEEFPTVRVIPFKNEEMLCTIAVVDPDVPDSKKHGFRYRCHWVVSNIPISPMQTTAVGRSAKPADTIVPYLPPHSQKGAPYHRYTMIVFEQPERIDTTALEGSINRDDFTMRGFQSKNKLHPIGAFMWRVEWDSHTKEIMQKHNLPGWDIMYKRIKDVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ62</accession>
    <name>A0A2T6ZJ62_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1090244</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ62"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ62"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="226"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="161"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="235"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="427"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="499"/>
            <end position="500"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU75464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="513" mass="56040" checksum="5442E089A96C489C" modified="2018-07-18" version="1">MMAAEAYPSYPPELSQTQLSYLLQNLMDYSLSHGLAVRPAESFISKELSSNGALATHAPVTLFPSPFSRSCLEEGRAVQKDYNELYARVSGNEEWLEKIIVELSEVDDFMARLYKVHLDVKAEGFVQPLSLGLFRSDYMIHNPAEDPNALPVIHQVEFNTISSSFGALSTRVSELHRHLARMGAYPSDSIIKTENIPVSPALPELAKGLAVAHKAYGSGGEGRSTAILIIIQPGEKNIFDQRWLEYELLERHSVQTYRISLPDVPKLTKLASGTRALIYSPPQAPNTQIEVSTVYFRAGYGPEDYAGEDDWAARTTLERSKAIKCPSVITQLAGAKKIQQVLAVDGAVEEFLADRNVSSRVRGTFAAIHPLDQSPAGMAARKLALEKPDTYVLKPQREGGGNNIYRGDIPGFLKSIPESHWSGYILMELIQPPALENTIIRNGGLMSGGVVGELGVYGAILWKDGEGEERGKGLKEIVMNSEAGWLLRTKGRQSNEGGVAAGFGSVDAVLLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ87</accession>
    <name>A0A2T6ZJ87_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ87"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="428" mass="47147" checksum="F8356811AC466684" modified="2018-07-18" version="1">MLRLGPSARLLATSPCRLASSPGLFASSRNLLTSFPKHGPTTLKISDAGVIPFGPNLAIKAYQIPRQIGTEHFLFETAESDSRDLPVGYDLFPSSPSSPPCPSPPPPPLPSSPFSLDLMLQSSRKGPESTQKQVAVNFRVTSVDNERNDAVPELGIVVDEESATKRLTTKLVSVKKLAGPPLVWLDELEEMKDLLPLFGLPPLPDASATFDDTAPVDVDIEIEMEKVPCGTNFRCILDRVAPFPRQLGSSPGRLRSFPSQSAPFSTYSAPRSPDTFGNEKKDGEKKEKEEKGAVEEKKDKDAVDGQFKKLEANFKLLLKCFVGVVLGLLGAKYVVDTAMEARLGVRIDLVGTRIDQQSALFDQKLSHVETRIDQQSTLLDQKLSHLETKLNGSLETLESRMKANTKGELERLRLEIRNDRLKDTGKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJF0</accession>
    <name>A0A2T6ZJF0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000222">
        <property type="protein sequence ID" value="PUU75615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJF0"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="225" mass="25343" checksum="2873808193E397AB" modified="2018-07-18" version="1">MPPRIITLVRHGEGQHNATRNFQIHDALLTPLGETHCHELSKEFPSEPPVDLLVSSPLRRTIQTTLLGFKKQVESGVKVELLAELQEVGKSPCNTGSSRDDLEKEELFKELDFSGLPDDWTSKALYAPLDPHPLSERARVARKWLRSRSESHVVVVLHGNFIHYVTEALDSNGNLPGTRWSYTEFRSYVFVDGDEDNASIIETDESKGRREGNEKSLGGMEVIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJL8</accession>
    <name>A0A2T6ZJL8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_993484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000218">
        <property type="protein sequence ID" value="PUU75687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJL8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJL8"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000051">
        <property type="entry name" value="Putative kh domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="262"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="474"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="519" mass="57002" checksum="3DCCDD1A47044F20" modified="2018-07-18" version="1">MTDDSSDRRKRSKWDEPQRSTSHGSRDHVRDYRDRESERGKPASSRGASRWDDRRSRSPNPHHQFSSRRDDRRRSRSPPSASRSTESPPLEPAKEPKPDPAAAAAAAAARINAQIQAKRGIQHVDVPPIRSSAGKSSSPPSTTTFNSDMYIADGDYIKDIEVNDLRNRYTLTKGATQKMIKEETGADVTTRGAYYPDKSMATPQNPPLYLHITSTTKEGLEKAVSKIEELMKQDLPNLVDERRFKRREPPEPVERDEYGRRKWPEEKIPVDLEPIPGFNLRAAVVGHGGQYVKHIQQETRCRVQIKGRGSGFMEHGLGHESDEPLYLHVTGPDPREVQRAKGLCDDLLTSVKSQYEDHKKQPQPIRFPSYGGGGNANPYNSPMSGHQPQGQNQGHNPHNLNHSHGQSSSPPPPPPPSGPPPQQAAVTASGAPGAPGASHVNPYAAYYGGADPYAPYGGYQAYMQYYQAYYGQQQPQAPGASPYSAMPASSPPPPPPPAGNPPPPPPPPPSYNTVRPPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJM1</accession>
    <name>A0A2T6ZJM1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_993694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000220">
        <property type="protein sequence ID" value="PUU75646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJM1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJM1"/>
    <dbReference type="OrthoDB" id="3780939at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="17342" checksum="7A271113C26564A6" modified="2018-07-18" version="1">MLQKLLSSGQMTLYERQYTYELLKQVGMPVIRDRMLQILKFLDPGGVASQHLQFTTRPRGAYLVPGPNFVRSIDCHHKLTMYGIEIYAGIDAFSRHGWYIPWIYVCISTRTEVSYLYTGVLPHAIRSDCGTETMMMASTPWPLYQALCPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJR0</accession>
    <name>A0A2T6ZJR0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Small subunit of acetolactate synthase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_993512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000218">
        <property type="protein sequence ID" value="PUU75686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJR0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJR0"/>
    <dbReference type="OrthoDB" id="2013116at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="314" mass="33891" checksum="5341DB9430034A8E" modified="2018-07-18" version="1">MTAIRTAYSSLLGRPAVNALSRAIGRVHSSSSSSSSSTSAIYYKALHRRVNPLPTTDPPAWSASAAVSSILYETPLPSSNPPKPHILNCLVQNEPGVLSRVSGILAARGFNIDSLVVCNTEVPDLSRMTIVLSGQDEVVEQARRQLEDLVPVWAVLDYTASPLIQRELLLAKVSILGPEYFEELLAHHREMTAENAEALGGHGVAPRDGDYHPSKLPISQALRHKHQHLHAVTQLTHQFGGKVSDISENNCIVELSAKPSRIDAFMKLIGPFGILESARTGLMALPRSPLQTRTEDIEVKDAGDVVDASTLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK40</accession>
    <name>A0A2T6ZK40_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="5">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_306209</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK40"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK40"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="892"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU75860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113528" checksum="8E6FFBB23BEE7B93" modified="2018-07-18" version="1">MTDTSSNMQLDSPADTAAGTIDEGLYSRQLYVLGHEAMKRMSQSDVLIVGLKGLGVEIAKNICLAGVKSVTLYDPSPIEISDLSSQYFFQISDVGKQSDEVSAPLLGELNTYTPVSVLRSNPFDDVELLGRYKAVVVAGIPLSAQLKVNEYCHKNKISYISAETRGLFGNIFCDFGEGFVVIDPTGENPVSGIIAGIDSSGLVTALDETRHGLEDGDHVTFSEVQGMESLNGAEFKIEVKGPYTFSIGEVSSHGTYDRGGLYTQVKKPKIINFKSQAEQLKEPELLITDFAKWERPSQLHIGFQALHQFREKSGLPRPMNEEDAGEVFKYATAIADSLGELKPELDEKLIKELAYQARGDLAPMCAVIGGWAAQEVVKSLSGKFSPIVQHVYFDSLESLPTSVPRTKENTQPLNTRYDGQIAVFGKDFQDKIANVKEFLVGAGAIGCEMLKNWAMIGLATGPEGRISVTDMDSIEKSNLNRQFLFRSQDVGRLKSECAAAAVRKMNPDLNGKINTLRDRVGADTENVFDEGFWESLDGVTNALDNVEARTYVDRRCVFFRKPLLESGTLGTKGNTQVVMPGLTESYSSSHDPPEQSFPMCTVRSFPNKIEHTIAWSRELFEQYFVQPAENVNLYLSQPNFFEATLKQAGNQKQILETIRDYLVYNKPLTFEECIVWARHEFEKQYNNNIQQLLYNFPKDSTTSSGALFWSGPKRAPDPLTFSLDNETHMAFVKAAANLHAFNYGIKGNATDEVYRKVIGDMIISEFTPSSGVKIQASDAEPDPNATQTGFDDEGEIQRIIESLPTPSALAGYRLVKVDFEKDDDSNHHMDLITAASNLRALNYGIPTADKHTTKGIAGKIIPAIATTTSMVTGLVCLELYKIVDGKNKLEDYKNGFVNLALPFVAFSEPIASPKGKYQSKEGEVTIDKIWDRFYFDYDATLQEVLDVMASKGLTCSMVSCGVSLLYGSFFPQKKLKDRLPMKLTKLVQEISKKPVPAHTKNLILEICADDETGEDVEVPYICVRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK92</accession>
    <name>A0A2T6ZK92_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fumarylacetoacetate hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1089302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK92"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK92"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="5">
        <location>
            <begin position="87"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="346"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="63898" checksum="5516D7228EEC6E1A" modified="2018-07-18" version="1">MTVPASTPLTNFVTYTPPNSTQTRVGHLDLEDSKITPLSHPSGTPLANLYEVISAGRNAQFIPTSKFQSPLELSSVTLLPPISGRDVLAVGKNYAEHAKEFNSSGFDSSDKADQPTHPVIFTKRATSIVACGSEIFPHTGWTETLDYEGEIGVILGKEGFGIPESEAWDYVWGFTIINDVTAREKQRDHKQFFLGKSADTFCPMGPIAVPITSLPDYQSLRITTSVNNELRQDSNLSELIFSIPTLISTISSSQTIQPGDVIATGTPAGVGIGHTPPAYLKPGDVVQVSVSNLGTLTNKIGTPSKRPPPVLQQSPAPPKNFTQLTTLRNGKQVYVERYGDQNSFNIIIFIHGLGLNTTFYHPLLSPALLKYNIILYDLEGHGQTPTTASSSTSIPTYVDDLENLMSSLPLPPVSRISLVAHSLGCLIALTYASKYPLQNLILLGPAPTPLQQSSAEVFLKRADQVRAEGMLPLTEAIISLAMSQKTHTANPLAVTLGRSILRGNDVEGYAKCCTAYARFTGEGINWERLRVSGEKVVIAGGEDKSAPLNIIRKTAGRIQARLVVLEEVGHWLVMEDLKGVERVVEEVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLK2</accession>
    <name>A0A2T6ZLK2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_258013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLK2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLK2"/>
    <dbReference type="OrthoDB" id="5404892at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27505" checksum="C7F7D58AD52EB78F" modified="2018-07-18" version="1">MGFVSVGRSSTRLNRTFGKRHNNRPPSPPPQKLRKTRSSSCSSSSYSIQLSATSSPNPSNPQTPLFTASPPPPLIRNPPALQTLPPELLQRIFLFSKNLQLPATTLHLTRALSTPILKHKYIRIHHGSHIPPGLLHRRFFTAQFLRDHETRYQSTLKFAPDTFLPPHRYSVEVLRLLLFRGATLSAEDSDEWTAVLREGIQEADLEFIRALLDEAGAKPDQECLRLAIEMGWVEGMEVVSGWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMS0</accession>
    <name>A0A2T6ZMS0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000175">
        <property type="protein sequence ID" value="PUU76790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMS0"/>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="12408" checksum="FDA0E86501BFD4F0" modified="2018-07-18" version="1">MLTQQQVHGEPATVLLGATKILDLGSGGISGLGVQTHRNKDGTGLFDRDSDHAVKYAVNWLKEHGLKFVWTKQGETFVETKSSRLLGALPVMVAEMTPDPVGHYCGNYECHISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMX8</accession>
    <name>A0A2T6ZMX8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1028191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMX8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMX8"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="361"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="762" mass="87167" checksum="DB6CD2DC4468A936" modified="2018-07-18" version="1">MFRYEDPTEEDQWLYYLNRAERILKESEARKGQKRPNKPPRSLYIFQHNFQNKGFPGEWGRDRSPKLTAGLATNIIYNEHPPCIVPFATLERKFLDDLRLEIAHRGSYIILRAVVNPNKYVSVTTIAEDENGEVELVQIYNQDDRRSPTSIMPEGQVFIVKEPYFKTTSEGGTSIRVDHVSDIIFLDGEDERIPEKWRPRIKLLGRRSLDWKDDGNRFYKGKQYFEAAQCYTKGLEIVEPGSASDIVLLLNRAQAYLELGYNEKALADANKALYYEPLNQKALYRSALACYEEGDYESTKTQLVKLLKEFPENKNAKEMLLRTFRRLQEQRTGEYEFLKMRNEVKEWGDKRGKLDCAEYVGPVSVGDAGSKGRGLFTTRDVKFGDLLLCSKAFNVCHEEAANARIIALFNLKARKGQAGTHSQLVQELIQVLYHNPKKAKEFYKLDSGDYERVRGEMVDALPVVDSHLVMHIMLRNCANCTRISSVDDPLENLFKTRSEVEKTIAEAPLTGRPKGSGLWIMPSYINHSCWPNSVRSFLGNLLIVRAARDIPQGEEITINSIENESGVQERQKAFYSEWGFNCKCALCEIEAAEPQEVQDKRQELVEKALKFDVYLKQSVKRNSGIAPLITLIKGIEATYSKPEFIHPRVPLLSPTHILQTFLVRAERPPDVFFLAKQALNGLGFKITTKERKVVIERYGYMCYPVMHMFVHIITAGAMAGDLLTAILWKDITVKVYEVLVGERESFFDAYGRALLQAGVPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNA3</accession>
    <name>A0A2T6ZNA3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1109160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNA3"/>
    <dbReference type="OrthoDB" id="5448793at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="457" mass="53537" checksum="DB08468DB89D941F" modified="2018-07-18" version="1">MTKGNKELDDSFPGGLPGGIDSSDGTGACISSFLAQYQTSLFLGYRDQWRSALLAMRTRIMDRGNPSLKYGWEMVTLANQFLSQTEVGDFPGRFCENIYEILGAMGRAKGSLNFYSASVISFYEELTLSLIFLVRPYEFLIPDSWHCLYFKRWERKYRSPSALERFRYKQCLAKVCLSFCKMVINIEGSPTKEFALAWRSITLIVVCLINLGTFFPRPREYAELWRKSQEVFSCARLDARGIQGLRGDELIGRLTKVFQEYRGKDSIRLVWGRQGWVDSFAGIPLKGNRISVVPNRPTEERNRNLRKPSRDQRTRKLNAAHILTAFWKLNGPRVLKKMKEHRDATHTLAAFWKLGKMKERRNAACILTNFWKLNGPRFLEKMKERRNTAHILNAFWKLEKMKERRNAAHILTTFWKLNGPRFLEKMKEHRRYFAPRYKYPKNCCLLVDMRGDRNWMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP08</accession>
    <name>A0A2T6ZP08_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1146549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000158">
        <property type="protein sequence ID" value="PUU77221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP08"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="31216" checksum="B75225C235B7B004" modified="2018-07-18" version="1">MSKSGKRIDCLITYFELKLVLICSTRDRPFSSSRTTGKPYFLRSSSTSSSGLSNLFQTQLVPRPTNSRFLISNFAVAQKVRSQALQVIWVCTIPNSGPLRYLVISNIELAFSTKLEVLKVVLHPKGYGFSKLPRVTNEISNIPEKKGLLFAKGEKCRVERKLLRPAFPHTHIKGLVSGFWSNRVEMSEKVAGVMRASQGLAGGWGRREVGSYEFRALESSSVSDSSNTEEKSGPELADAYNTIFNMGGIPDRGDAIYDISLPPRAIPIAKASPRRCAARRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP09</accession>
    <name>A0A2T6ZP09_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_182187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP09"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="86" mass="9527" checksum="FC4CDF7488F8D7EF" modified="2018-07-18" version="1">MAPKATYRYVQKRKGGKSPLSFSGTNYFAINLTTGTQRVNTGTQIVNIGAQIVNIGTQIVATGTRHREASFAHTKVAYQRKILKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP48</accession>
    <name>A0A2T6ZP48_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aconitase/3-isopropylmalate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1128507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP48"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP48"/>
    <dbReference type="OrthoDB" id="5149968at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170034">
        <property type="term" value="P:L-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170038">
        <property type="term" value="P:proteinogenic amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="5">
        <location>
            <begin position="60"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="6">
        <location>
            <begin position="214"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="343" mass="36580" checksum="B0B023DDC5E156F5" modified="2018-07-18" version="1">MTLGHEVQNGGETSLGKYQNIKELAKRTGVTGKDVIVLICLCAVISTTTRFSTTPLSFSGVEFYIAVASTLEEEAATKAGNLDAPTNAGGKGLPAGCGPIIALGISPPNDGEVGIPATNRSFKGMESREALAYLASPEVVAASEMNGFIAGSGNYNGSSSAASISPTLTSPILNPVLERLGNRNRDTPRPPPLMEGEIAFCDHSREQMAQVYWENYGSSFPTILKPSDILFAGFNFGCGSSLEQAVTPIFARSIKLVVAGSFSNIFMGNSINNSLVTVELGNLIERLREKFPKMLTRRRGWSLRWDGCTSKVIVREGPEDAEEWSLGVGELPLHVQDVFVKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP70</accession>
    <name>A0A2T6ZP70_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_987363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP70"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="7417" checksum="E1D05778E7AADE0D" modified="2018-07-18" version="1">MVGGGPESEKKEDGLDKGIDYVQEKFLGQGPQNNESALEQAKDEQISDFIRRQYKGATGKEFPIADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPC7</accession>
    <name>A0A2T6ZPC7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPC7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPC7"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF265">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="135" mass="14972" checksum="3185C39780F1BCA8" modified="2018-07-18" version="1">MAENTVACRLFSSGTSGLPKGVEITHYGLVAQHELAHETEKGLENPILTLKLPMFHIANVPLAFMSMLRTPRIGYVPRRFDMETWLSTMEKYKATHTSLPPIIAVGIVKSPLMDKYDISSLRSVISASFALNPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPL7</accession>
    <name>A0A2T6ZPL7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1065848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPL7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPL7"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015786667" evidence="8">
        <location>
            <begin position="23"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="479" mass="50697" checksum="FE51E21342D80838" modified="2018-07-18" version="1">MRFSRKSTSLLLLLVAPPLIAAANSHVPIEYPEGATTVGKKKDATLPLNPKAPYKISDTQPGAGPLKPKVEGTADAPVDGLDGKPHDGPGLYPGTEEKGSGEVGVSGGGASVDIKKPPPHTGEHEIVEIEEPAEGDDSAIKTPKSKDKDAKDDPSTPKPPVPKTGHQEYTGSQGDTIKNGGPPVEIPKHLKPEELEAADFSGISQPFHSFALSFIMIIFSEIGDKTFLIAALMAMKHPRVLVFTAALSSLIVMSILSAVLGHAVPTLIPKRFTNFLAAGLFLVFGVRMVLEGLRMEKGTANVQEEMKEVEQELEEKAAERERGASVSRNLESGLVSSPSRGGLGIRRSTSSPALSDSDEDDYERARGKGGSGKARMTSLEGIQNLAGLLLSPAWVQTFVMTFLGEWGDRSQIATIAMAAGQDYWYVTIGAISGHAICTGIAVVGGRMLASRISVRNVTLGGAGAFLIFGIIYLGEAFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQA2</accession>
    <name>A0A2T6ZQA2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1128062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQA2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="417" mass="45422" checksum="314BCA5B2EB6B0E2" modified="2018-07-18" version="1">MALQNSGGVRHAIKKPFSDSVLRYPIYPQPKGHLHTTIFHGATDQIPGALGVRSRSHFTTAFYAILSVYRHKDIPIRAFSMALQSLLKGEFICRVFLDVWKALTLKPDSGGVRDAITKPFSDSVLRHPIYPQPKGHLHTTIFHGATDQIPGALGMQSRSPSATAFYAIPSVNRQKDVSIQAFSMALQSPLKGDHYAGQILRALSMGSRSPFTTAFYAIPSVHRQKDVPIQAFPMALQNSGGVRHVIMKPFYDGVLHHPICPPPKGDPHTSIFHGATESSEEGPDSGGVRHAIMKPFYDGVLRHPICPLPKGHLHTSISHGATEFSEGGVLMADSGGVRHTIMKPFYHGVLHHPICQPPKGHPYTSIFHGATESSEGGIPGTLGMRSWNPFMTAFYTIQAVHHQKGVSIEGVSIALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQA6</accession>
    <name>A0A2T6ZQA6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rrp15p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1065663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000145">
        <property type="protein sequence ID" value="PUU77670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQA6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQA6"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="253" mass="27526" checksum="909B845D295C11DF" modified="2018-07-18" version="1">MPSHFTKKRKISATADAKKKNIPAEKRKPASPSASSSPSSSDSESTTSAGGVDLNKALEASDSEADEYSLSSSSSTSATNSDDGSDSDDNLSDLLSTPHTTKKRKRNDPEVFSTTMSKILSSHLTTTARKDPVLVRSKHSAVEIDESKIEAKARRVLREEKRKELEKGRVREVVPKDDDEAARKALELEKRLRKTAQRGVIKLFNAVRAAQIKGEEGSRVLKSEGVVGIAKREEKVTEMSKQGFLSLIQSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQX5</accession>
    <name>A0A2T6ZQX5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1193728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000137">
        <property type="protein sequence ID" value="PUU77873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQX5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQX5"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="284" mass="31363" checksum="9C4FB8BDAA918803" modified="2018-07-18" version="1" fragment="single">MSNNDGKSPDTKGVLRRAKSNTPIKVAPYPQKSHYCPIPSCGRSFKKLLRFEKHVRAHTQERPSTSNVDEKPPAFSWGSLKEEPKKAEEAHHTPFSIDSEYVSAATPWDEDGILQNVFDVSGYPWIPSHSSQTNPFWAPPSPTPRRSTPTTLNITEPDFLSLAEQDAEDYMRESKLRQDQQPSHLVQSEWSLAVSPSSYNYDSVSSYATTPENPIEPLDAEFGDGVECEPEASTSELQPREDKQTSFLALSQSPLAGSAFSHDYEATNSSSAATPQGGSLFPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR41</accession>
    <name>A0A2T6ZR41_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1026105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000134">
        <property type="protein sequence ID" value="PUU77960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR41"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR41"/>
    <dbReference type="OrthoDB" id="5325022at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="18"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="245" mass="26519" checksum="AB813CB2F988E292" modified="2018-07-18" version="1">MAAYTDQHVVEQPPWLKFIRIAQVALSVLILALAAFALSAIPFGNTFGTFGFNIFTCIFTFIVGAYLILTPIKAPKLYNCWAALVLEIFGVIFWLSAFATMASWASLGLLTVGGISGLGKRDAKKSKSSSSDDLFGSNSDWLDNYDKEIQARYARYRAGWRCAGAAAGLGGVVWVLFMITLITYSIFLHRHRKNPENKNLPDNGMPARDGGEAGVSCHSAAEVKGHEMGSVHVGAVGGGEYPKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRH8</accession>
    <name>A0A2T6ZRH8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_984338</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRH8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRH8"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="18921" checksum="ED662F6D66189393" modified="2018-07-18" version="1">MTDESEPVVFLDLALGGEPLGRIKIKLFSKTVPKTAENFRVFCTGETKGRGGRPLGYKGCKFHRVIKDFMIQGGDFLNNDGSGALSIYSSDSFPDEGFSIKHDAPGIVSMANSGPNTNGCQFFITSKVAPFLDGKYVAFGQVIEGMEVVRKVENVRVILDRPTTDVVITQCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRK7</accession>
    <name>A0A2T6ZRK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_984228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRK7"/>
    <dbReference type="OrthoDB" id="5316527at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="426" mass="47657" checksum="A5D6ED17DD1C5872" modified="2018-07-18" version="1">MNDGGAVYRVRFVPKQRRFGTFTRALIWLSGFQLAANGLLQIYGNGWENPIFIPLGFTEFVPEREYGPDDPEYAMYMKFRKDPRRALEGKRRVVDALIDYLGKRYGKKFGGNIEPEIATVYYHYPLRPREYKRRGRVHSSTPSQSHKLILPRLKISPPPPLSDDTLPPLRISNLTYEWSTRPIPTATMHRLMTALYPTWMFSSVTTSLQHTYSFLQASQSSTLTSPTSSPIDLGKRAISHGIQSGIVQLRRTYRRPPAPQGHVVLDGLVQVAGDKLRVAMDVTVSFHPEDLNSIIFHKIDVRYVARNNKRQKVIAPPVSPPHHQVTTIRVVVKSATEQPKTEIIEAAAALQRSNVDKARSFIDKQDKERKKVQKEAVEVGVEKEVTAVAPGTDGAAVNGPTPPVSSGEQEKEGPKRAGDDAASSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS15</accession>
    <name>A0A2T6ZS15_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HSF-type DNA-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1101477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS15"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS15"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000229">
        <property type="entry name" value="HSF-type DNA-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF396">
        <property type="entry name" value="FLOCCULATION SUPPRESSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="6">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="506" mass="55548" checksum="833625B9837E1C92" modified="2018-07-18" version="1">MSMSVDTPMGNAPNSGPGLGLGGAAGGVQQPKVQTAFIHKLYNMLEDANIQHLISWSPSNESFVVSPTGEFSKVLSQYFKHTNISSFVRQLNMYGFHKVNDVFHTGSPDATLWEFKHGNGSFKRGDLVGLRDIKRRASRHALIHRDSFSGPKSTVVSAPGTPDERPGDSIDGRFMSIEQSLYEINSRLARSEDHNAMLGIRLQTAIEGLTRCHQVSPEPLRVASFPFTRLTGREVNSMQKEIERHTQLLEEPQDVLLRERQPFLSSLAIDNSAPLSPRQRPMEDESRRSSITGPLRPSGYFRAPAPPMSNAPRRFGSVGLAGGSSPNALRPQQPSQQPPAQHPLASFHSPPSHLSRRHTSADIRLHGWQANSPFSGMSGSTQWPPSPNRSSNLQHDNTREILASYEIQQHRPPNNPVFTSQTTPPLSETASNNGISDSSWSFGGGGPKFPPQREAGHTAPPTRRSSLASSSVHALLNPPDSNLSAEANRDGMSDCEPDDRKRKRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS46</accession>
    <name>A0A2T6ZS46_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1143055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS46"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38360" checksum="0F051F51647241D8" modified="2018-07-18" version="1">MKIASSAALSPSCIFSPTSPQKVSQAVKTFTDNQCKFAILGEVHSAVPNAAYANDCIPIVTEGLNELILTNENSDYLGPYHKSVVAGRYYPIGTGLLLRTGLSFGNEYGRAIDNVKTYEVVLDTGTIIHANATSNPDLHLALKRGGDNFGVITRYELITLDTQDWIWGGIVYYNQSQPSQVDGVLYNYHVDIAVNDVKAHVLLRFGFKGTTNETIKFSPIFTTALKIAPPLLSNPGSTLTRTKHNAPDPGRRPRTGYKNIPGFYGLHFNMPVTPNAVQQGVRKGGNMLGMGVFPAFATFVKSMLSLAKKRSVRHPYIMWSYIGHDEKIKACGEGNNIFLPRIKEDYDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSJ2</accession>
    <name>A0A2T6ZSJ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Guanine nucleotide binding protein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1101316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSJ2"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002307">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU78448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="353" mass="40956" checksum="DD0AE5BFEE0A9C4A" modified="2018-07-18" version="1">MGCGMSTEEKEGKQRNEEIENQLKKDRMMQRNEIKMLLLGAGESGKSTILKQMKLIHEGGYSRDECESFKEIIFSNTVQSMRVILEAMESLELPLDDSRAEYHVQTIFMQPTQIEGDSLPPEVGNAIKTLWADRGVQECFRRSREYQLNDSAKYYFDSIDRIAQAEYLPNDQDVLRSRVKTTGITETTFIIGDLTYRMFDVGGQRSERKKWIHCFENVTTILFLVAISEYDQLLFEDETVNRMQEALTLFDSICNSRWFIKTSIILFLNKIDRFREKLPISPMKNYFGDYEGGEDYAAACDYILNRFVSLNQSETKQIYTHFTCATDTTQIRFVMAAVNDIIIQENLRECGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTC3</accession>
    <name>A0A2T6ZTC3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1126296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000110">
        <property type="protein sequence ID" value="PUU78674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTC3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTC3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="499"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="569" mass="64812" checksum="F48F99D055FD1966" modified="2018-07-18" version="1">MLAPLFVTSVLLFMGYTCYSLHILLCKVRPLGIPYFVIPFYHSPLQRLFLFPLVKLLIKVFGLTHPRFFLMTLDWQVRQRYEIYRLIGSDIFFTVTPWKIILHVADPDMAIEVLAGKGENGELYSRPDFFSGIALFGENLATVEGAVWRGHRKVTGPVIGKSLSIVWEESLTQIEQMIRYYDKSEAINTSYRDFRRATLGIMTRAGFSKVMRWAPLTAAIADEKDGEGNYQKCLDILFGNLMWPIIAPSWLLEMLPFKALREAGRAANHFRFFMNEWFEEKKAQIELDNKTALKHSSRADLMESLVRSSGLDKGSTLETPLLSKSEVIGNAFIFILAGHESTAHTIAHAIYFLAIYPEYQVKLQKEIDSILRDSDHNKTSYDTHYDAFSSGWIAAILFETLRLIPAVIGVSRKIGPTPRTFPRSGGQRPITLPPGVEIWIEFIGLAQNPKYWTQPGKTEAESAISEFRPERWLPKPGGDTMFKPYNGSYIPFSIGTRGCIGKKFALVEFTAIMLGLFREMSVEFDSCGGRKTFDEARQECLAEMDRFKSKITLQPSGEMPGIKWVRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTM0</accession>
    <name>A0A2T6ZTM0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1125968</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTM0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTM0"/>
    <dbReference type="OrthoDB" id="5355583at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="3">
        <location>
            <begin position="314"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="435" mass="48284" checksum="75B08773AD2ADF2F" modified="2018-07-18" version="1">MSHRQAEKRLGFVLETIDEDAVPVKHMIATSDGGANIEGLTPNELEGVRAKVYERILEFLEGEGYPSETNEDYKEANVHDLVYTILIPVISIFRRKTGRNLRLRREKSIIASNGEKDGNQEFVMIDIVGVDDRKFVFLMEAKKSSLGEAKKQCLLAMKDMGEMNGGGVVYGFVTTGEAWQLLRFEGARPEVLGQVASMLKIYGIPAEEPFFKWELYCIEMGLDDTKLNLDIVQAFKEDVHEFGRGIKSKLRMHGTTTSRPVAELQLYTFCTMKNVGSTYKVLNEHIPKPSLPLPESLADAELASPMHQKLSEVSELINDYVDEPMDTIQEPHEFANNQFGNPSTASLSEIIGVGRTSCNTLGGRLSPSSVLLEASRKIGAGSRAQLKLDALPSYSFFSRQIVAVKGVNRSSECLAVGEILQVHHAPIRQFLGDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTX0</accession>
    <name>A0A2T6ZTX0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_981081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTX0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTX0"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000146">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="291"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="543"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU78915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="610" mass="66281" checksum="1C5901B857B8AF35" modified="2018-07-18" version="1">MSSTNHGQNGQADGLNLQHFAASTDEDSLYGPTAADQGYTGFQRYPRYELNQQPLEDIRRSASPHLQASTAPPPPQHHSRQDYSDFSLHSTSTDPTLFDYESKEGLTGGSINPADLMNPAYSAHSSQQNTPPLHIHPNQQQSSQPDSATFLSSGSTNPSSGFEWDTVYARRENAWESHRKAPSEYSDISSAAASPFLQNSEFPEHPSPLLQGHNLPQQGSMQEFLNSNQDFNTGGESFGLDQFSLNERDASPHVSPRISPAPGQLNSGANSPYMLPQENQFLTYVPPMSQDQGMGLMQPSHPPTGHGAGPGVDRSSPGEEGPFPQINVIFAPPQRQPTFPGKPGFAHDDGALSPPPKSEPGNTASEKRVQKHPATFQCTLCPKRFTRAYNLRSHLRTHTDERPFVCTICGKAFARQHDRKRHEGLHSGEKKFVCRGNLKPGGAWGCGRRFARADALGRHFRSEAGRVCIRPLLEEETAERQRNQMLAQGQMLDPTLGHLANPSDQQGIMGSSSMDPGSGMVFPSALLEQYPALANMEWGNMASGEQDDIADGEGSNRSSFDASGGEWDEASASGGSALASHRNSYDGSRADWSGNEEWASDTGGEYQHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU61</accession>
    <name>A0A2T6ZU61_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1140506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU61"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU61"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="601" mass="66819" checksum="0144D0B59E64E850" modified="2018-07-18" version="1">MDKAQSDLIEWYKLETKFFPDHVRHTRYLGEARNRNKREEEDWSNCGELGSGGFGVVYKQIRKTTGRYRAVKTIDKRPPLKLDYSRELLVMAILAKRPPLFVEFLGWFEEPEALYIAMEYLEAGDLTKHIGAPLLQETVRHISKQILEGLNVMHQQGIAHRDLKPANIFVVSMSPVWVKLGDFGVSKRILAQATTTLHTPVSTQLYSAPEVLGLDSSSETSNYTNSVDIWSLGCVIYELLAGAKLFPLEGQVSRYFFGKWPFPEDKLKGLSPPTDDIGISLLKSMLLIRPEDRPTAAGALSHGWLAGLESYGEESGDDQDQRAQSLGEGASGRRGRKQLAIHDIPKKKRRERNPITQDDTKPILGGVVLGARSQGGSHATTPKARIDGSIITQLDVVSPKNSIFQMGSLEPESMPQSYLITHSTGKGAKTLRRKQVHTIPQSHSQSSTPNPKLSSYTSIKGVANQNWMLNARPPASDPPTADPHHGNSLRSALRTNGPMEHGPKKIHQAAASDLYGTASRIAYQRTYPTRPVRGDGRGHNGPTINSMRTPKTRRNCNTRQDLDPLQTPITGWNPDRNPNILRNPNRDPNTGWNPNRNPNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUF6</accession>
    <name>A0A2T6ZUF6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_19986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUF6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUF6"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="23710" checksum="C65ADAFF863D6149" modified="2018-07-18" version="1">MSGKANEMPVNPQEPGEVEAIGKHCDLPECHLLDFLPFKLNCTTCRKQYCLSHRLQDQHDCDKVKPPPPAAATANEKAKAALSRFKAWTSSKSDKVIQSTRPGASQIAELNKLKRAAKGDDKVPVGKRVYVYVEAEARTTTSKLPRGEFYYSNEWTVGRVANLNNKADDDEKKLRVFHVEGGRVLSFGEKIGDAVGNGNTIVLLRGLQMPELME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUI3</accession>
    <name>A0A2T6ZUI3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUI3"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF11">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="116"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="245" mass="26540" checksum="2D97AEF57546FDE8" modified="2018-07-18" version="1">MPLLDFPIEVLRLVAKHLSPGDLNSFLSANRHLAVVLTPLLHDFAVQDKDGLPALEWAAIEGYEDLVTLILKRKKAECTDIGWARGALHQASAYGHEAIIGQLLNSGVVEVQSRLDGLTALHYASRYGKEAAIKLLLEHGAEVNARDGRSNDTALHFAVHGFECVAGGRRMENELGIWRTFGGGPGVTCSGIQKGFLACVKVLLEKGADARLKDSCGRTALDIARKYKLGDAIGLLEEARLRPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUP5</accession>
    <name>A0A2T6ZUP5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1192834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZUP5"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="11">
        <location>
            <begin position="1539"/>
            <end position="1687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU79134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1821" mass="201761" checksum="2282BE770682FDF3" modified="2018-07-18" version="1">MASNLAAQLSAIAATSTNTLNTQKLKSIHSISLLFPPSIAAAQDTDTIFSIAIEGFRELCQLDKRFLLYEKGLFSEHSKNVDRFVLPQASAESLSKSIDGFLQLLCGRMLLQPALRALEWLVRQFRVQDQNAASLILCFLPYHDHPTLFKTMLSILHQKDLPREFVFLTPYLKKPSPVPKHVITHALSHHRDLLTLLCDYTTNAVSAKRDSHQLVSFFSVAITASVSLMCDSISSNKSGRAKNVPTAENILTSTLPLLDQAFSARSSSELETGCHMLTIVLVTKLSLTDTVLTAIIKSIVNHWTVGSCKTGLICVAYIAQSRFKDDVELPDEVISALLKLDAPEFGNKRLDEAFLSMQSKYRVDRLAVALCLGILKRLGEAYDAKGLRTVISLLERANMESHQRLLVTKKLVEAAQRVGSAAIGEESTDGTRELLAEALVNWAGPARGGRVGKVLAQVMADDAVDVDDLEMRLQTVIRPLPAAVSGSVKKAIKQAPARAQTLEDIISTIPNDTDEKTILAAKAKALFQDLLRFFAAAVLSKRQEKFIKLPLFKGLPPSNPLQISFLIECWTSHKYPVAMRSSALRVCAKIIQKQASKSVSIDYQAALPHILIALADPNRRVRSDAVDLTQVLFEHYKGLQKPVLGDKPSKKKRKRSSGAAEYWGLDTIYGEGKDSDEVKWLELDQVVKLMERITANGLFGCIEDPEYVSNMLAAAVGTGEGTGSSLKGSLKRSIFVFLSSHVVNAPGLEIRYRLLSQINKINLAGDIRTKNLLPALTNWLSVEDYNERIKQCETERLGIVAIEKQVVQVVNADEPKILIDILTKDVSHSLLGAAADRIRSIWSAIESDVQIELAAELLEIELDVMQNFSGVDVLERLRIPTAAFQQFFDKARTQLQVSLSRVSVGPNKRRKTGTDGMGKEVKAEELEAARRRATVVTDLLHTQGAERHSSLLKSLFGILADLASFHFSGMAYLNQVLLDCMSSIVTSVQRFGGSDIDDSVRPDVLVECIRAATAPQVQNRAILLLANLADVVPERVQHSVMPIFTFMGANTLRRDDEYSAFVIEQTIKRIIPPLVKSLRSQEGNQVVVTAELVNTFVASYSHIPSHRRVRLFVTLTKTLGAEEFLFAVIAKLGEKYLSTDAEHPTGEEAVVTSACKMIVENFDIDVQLETVIRYLDLVMEVLRHKKHGLSKHLFEVPKNNRCQLAERLLNLLFIVIGNKKLQDYIAKVDDGGDTRNKKFSEALERVLGPLEWGPESGVYEAASRVLSGLLYDLHIPRFITVVEHLIFNPESSFRGGALKTFRDRLTNVHRIDSASAKAIVGFAPKISTLISAHDPDKLSIDAIACITSMIKHCQSEMAPIVANVADAVVGHGGLHSSEDSTQAVSLVCLTNLAAKFKVHLIPILPKAVPRSLELLKESLRGGTEHEVLHDYVIAFLEELVKNIPGFMTSWLEKIMKLMYSSAAVMEDEDQVGVRVGFLKTISRRMQLDAILRVYAATWDEAIEGGEVAIEEALTTLEEMETSSKGDEKRSKATKRLFRTTDSLKPLLNLVLLLLDLRRRLLDLGETVDIEEGKIQELEDQALKVILRFVYRLNHSNFKPMFLQIIEWATEDFNKGSATSINRCIALWNFLYLLGNDLESIFTSYFGFALDNAVDILTNDTIFVTHLPLWKSALKALRVAFKSDDHDFWQSPTTFSKIAPVLTTQLARASTSASVVREYVYPALTELVGVTQGSEEHAKMINGKVLEQMKAENAMVRIAAAEALKDIYAQAGEEWLNFLPESVPVIAELMEDEDEGVETAAHLLVVGIEKHLGEGELQAMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUS1</accession>
    <name>A0A2T6ZUS1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUS1"/>
    <dbReference type="OrthoDB" id="3905365at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="337" mass="37381" checksum="158C92F8B6EFCDD7" modified="2018-07-18" version="1">MPTAAAASVVETVAPEPAKKRASPPKNCPCEWCGVLFSKSGLGRHYDYWVYSVSPGKPDEKHTPEAIQRMREIRKDARRLKGCDKLDPKEIKSRQNKRNYQRHKGRHVAKKRAKRMSEMARSMVLKEIAMEISAVATTPTYPTLEPDSEGLVNFPALVYAFLSPPADVFSAATTRNLSSWGDQIPGVTEYIALGVKFKQPDLSKWSQRLDLEWQNWGSLSELEKTGLCFQEMGRALSRSQADVATYKPYAKILGKFGGEELGHRIIKWEGRATQLRAQKGRAEEVQLEKEWMTTRDDQHLSHDNAPTEGGASGSGEGNWRTGGRGGSGASGSGDDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV19</accession>
    <name>A0A2T6ZV19_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1125326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV19"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV19"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001721">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="271"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="556"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="792" mass="85735" checksum="347148803ADA81A1" modified="2018-07-18" version="1">MPPTLNLNSPSKDTISSPHIFTIRPATSAGSHKTFLRLTLHRTALSALGVKSGELCQISAIGASEGKFFPVVAWLSSDPHVQRHVALISDNVKTLLGAGYEDKVLVERYTGRVIDATKVAVREGDGRSAVEEGWRWYLEHIFIESKYIYNGLSIPGTEYKGAKRLFRIETVTGEEGTLIEGQPVVYKATLSTVVELANPSSPPSKPITLPPPKLKSSKEPTPQLDSAIIVPSSKTNFSSIGGLAPQITALKALLLSTLHHSHHFTKRNLTPPRGILLYGPSGTGKTLLLKAIASEISARCYVLNGSVVGKYLGESEAAIRKVFAEARKNQPAVVLMDEADSIAPKRGEGDGNEGRIVSTILTEMDGMSYGDSGSAEAVKLVVVAATSRPNAIDQALRRPGRFDREVEIGIPNVDSRREILEILTRDIDFSGEQPKEATIKTLAAKTHGFVGADLEAVVRTAFTSALKRLEQDDLDLSTLTLNDTPEAQPQLLLRGEDIDSALKDVRPTAMREIFLEPPKVHWSDIGGQEEVKQRLREAVEWPLTHPEAFSRLGGTPRKGLLLYGPPGCSKTLTAKALATEAGLNFMAVKGPELFNMYLGESERAVREVFRKARAASPSIIFFDEIDALSASRDSGGRKGGGGGGGKTNVLTTLLNEMDGIEDLKGVTILAATNRPEIIDPALLRPGRLDTILYVGPPDLPARKQILQIKTGKMSISTDVDLGRLAEATEGFSGAEVVNICDEAIHYAMRESFLIEAVYTRHFEAALEKAVPQITTEMCEAYESWSVGGVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVA9</accession>
    <name>A0A2T6ZVA9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1082026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVA9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVA9"/>
    <dbReference type="OrthoDB" id="266020at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12247">
        <property type="entry name" value="RRM2_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000029">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="91"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="17860" checksum="7B9FFB73EE16BA56" modified="2018-07-18" version="1">MVLAFAKSRSDATVKREAGEDSQEFEAHKRRRLAERERKQALAALESQRHASTAAAPQVDAVKATKKSGGLKSTAPAAAPQIPDEYLPPNSTLFLQNLPDETDLDTLTSLFGRFDGFKEVRMVPGRKGIAFVEFEQLEGAIGAKEGIGGMTLGDKVVKVTYQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVZ4</accession>
    <name>A0A2T6ZVZ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B9Z19DRAFT_978499</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZVZ4"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000391">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="23">
        <location>
            <begin position="265"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="85"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="475"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="553"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1342"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="1342"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00059773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PUU79648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1364" mass="151977" checksum="BFFCE9A4689B8CF8" modified="2018-07-18" version="1">MGSDDEKPSSPARKLCHALGRSGSKKKKRFAPFRSASDPTRSMQLPSRFSTEDDSQTDVCAATEGTPFNMNQSFFQILTATTTRMSSRFDDEDSDDGGSPHSEPTTPTAETARKAKESADKHSADKGSNDFHLDSMKESRKDKERNNYDADSNEEDTSALTRVVSNSSAPYMSQILQAQAQMNSSNFAVAAQLKEAEMFGDNEEGPKDHPDLAKRLTEIFSLPETEEVISEYPCWLLKSVLLQGYMYITTRHICFYAYLPRKDNVVLKSGYLAKRGKSNVKYNRYWFILKGDVLSYYTDPSDLYFLNGNIDLRYGVQASLVESKGKEGTVTFLVATDQRKYYFKADSAASAKEWVKALQKVIFRSHNEGDSVKISIPVENVIEVEESPVLEFADTFKLKVVDNDDTYAIDEYFFSFFSFGKDALNVLRSVVEDSPASKLPKEIFTGSAPGSPKLSSSFSETPVLKEHVRDTLSLLSPVGSGRASPKPSGEFSRPSVELGRRSLDVSQESLRRSGSPARNSMGLDRHSQTSGASQPTSPNRLFSSESIVQSFGESSDAIRLSSDEERGTSASNILDRSDVFQSPTLKKPGRSEDPRRSSSLKGTRTCSPHPRLRLGSGKKARGPTTGSDSDTEATGKASPRLQDIAKSGSFPLQRAADWADWMRKRSKKVGVMIAAQPMSYLEKVSDMWVGGRRHYGGGAMGMMPNEEVEDVDDDDDETHHEERFRARFSLPSTERLQAVYFGYLHRVLPLYGKIYLSNRNFCFRSLLPGTKTKMILPLKDIENVGKEEGFRFGYSGLVVTIQGHEELFFEFGNVETRDDCAITLLQGLDDLRVLQQSGILTREEKEGAELAKQEHQMLQDARQIGHNIHDTQLPTGTNEASCPLNAPPIVFDDPHGSIINFKPAEPMKITCLTIGTRGDVQPFIALCKGFMAEGHKTKIATHLEFKDWIESFGIEFAPVDGNPAELMAICVEYGMFTVDFMKHATSTMRGWLDGLLLSSWIACQGSDLLIESPSAMSGIHIAEALGIPYFRAFTMPWTRTRAYPHAFAVPEHKMGGAYNYFTYVIIDNVFWKSTAGQINRWRKNHLGLPSTSLDKLQPNKVPFLYNFSPSVVIPPLDYSDWIRVTGYWFLDAQSDWTPPEELTDFIQKAREDGKKLVYVGFGSVTVADPQAMTRTVIESVLKADVRCILSKGWSDRLSKSKSAEEPEVPIPPEIHQIKSAPHDWLFKQIDAAVHHGGAGTTGASLRAGIPTIIKPFFGDQFFFGNRVEDLGVGICVKKLNTSAFSKALWEATHNERMVAKAGLLGAQIRKENGVETAIQAIYRDMEYARTLIKKHTADNQDESEESWTFVDDSEPELPHRHATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX92</accession>
    <name>A0A2T6ZX92_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear pore complex component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_976020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX92"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX92"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="258" mass="27484" checksum="E944A182E1D0B438" modified="2018-07-18" version="1">MSSAPSTPMKSAPASPATTGSWRHPALDDIAKRNANKRPDMSFKRLTMNALALIASFAMFTLLRKSEILLSLTPSSPTFHQYFSYVLWAARFVLAFNIVESITQLLSPADEFADIPLTPDQRKLLGLNPNTPLSASASMGNIVTPPRYTKSTPSSRTGSPSFGASTSGSPTLQRKSAPQTPPAISPSPLRMGGGLERRQSNGVGSPNVGLLSGGSPGVKLAGASVVPGNKWLYEKNIQRKNEGLRFSPSKSIFSTPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXI7</accession>
    <name>A0A2T6ZXI7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_756629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXI7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="20885" checksum="C9BD2CBA5C37A236" modified="2018-07-18" version="1">MRPSTVPSSCRQAGKGRRVGRVWMGGEEWRNLLDYCVTKLCCRRREIYSHHTGITSGKMIVRLAEGKKLEKSRPFTSFPPSSSASPPRLSRPSSHLPALLLCSLHTRTSSSIPPPPYIYPIFPYYPVFIYSSTAPTFRAHSSLSSALNQLAIPPDHQFQQSYSPAAQATFSGIGDSSPLQQCKNTQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY49</accession>
    <name>A0A2T6ZY49_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY49"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY49"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="171" mass="19367" checksum="528FF7AE6DE81C6B" modified="2018-07-18" version="1">MNHTILELRVNRDPKPKERTFLDRKTTFLSLAGGETRTTGLNYWDGRWDSGRGAAATKPSSPNQTSQPLNIPIAIESEDEGSDTQEEEEEENEEDEEDGDETGTDGVGDKYPSDDEDWTGKSTDKGVRVHLREVLFYDHKVACLERGMGNCNPLHWSIFDLLSSPFSWFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY83</accession>
    <name>A0A2T6ZY83_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_975081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY83"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY83"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015463279" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8726" checksum="9CD934BEEA7F8C21" modified="2018-07-18" version="1" fragment="single">VSTTHSTSSLFPLVLNLRLLEHALLVLPTFHYHARAAKLCQRFPSQLSPVRTNILLVRSQPSSVPELLCRFVAFVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYX8</accession>
    <name>A0A2T6ZYX8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1021137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYX8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYX8"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin C-terminal" evidence="3">
        <location>
            <begin position="171"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="422" mass="46679" checksum="63ECE9AE3A576741" modified="2018-07-18" version="1">MDDTIYSTSTQHRLFTFTPKQLSDLRYSTNKAAAEKITESIKRRATAAGIPESDIEEIDCPTAEEELKLVAYYCVKCMQLSDHFQFPSNVKATALTFLHRLYLTTSTLTLHPKKLLLPLLYLATKTENHYTPIDSFIKTAATAGPKVTKEDLLDPEFTIAMGLRWAFQVWHPFRGLEGIFLELNAIAAGRYQPPKPKEHLVPPAAEAKVALLELLAGDMDRIGRAHGEARRLLTTTALLTDVYFLYTPPQISFGAFLEADRELATFYLDIKFPESDLTGRKAKAKLLGILDEIAKNHLSAGLSKESKNPYQGLLLQLPQNGIATSLTTAVDPALVKEVTRIDKKLYRVTKRDQDSGGKKKTEEGSGSGSQSGNGNGSGSGKYDEDEERRAKKRRLEREKAEREGDVFGANLPDVRTAGAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ19</accession>
    <name>A0A2T6ZZ19_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid synthase-like central AT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1123095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ19"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ19"/>
    <dbReference type="OrthoDB" id="3033689at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055118">
        <property type="entry name" value="FAS-like_AT_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22690">
        <property type="entry name" value="FAS_AT_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fatty acid synthase-like central AT" evidence="2">
        <location>
            <begin position="136"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="35977" checksum="782C84E4EE56B7D1" modified="2018-07-18" version="1">MAAVSTSVAILYDEYVLDEEPFSVPELLCRFVAFHANLLFLAAAEKQPLTFMQPPEDRETLKNTLTSPEQSSAYGGLVDIGVFCHLPFVTFSISPPKQGVFQGTICCYSEQTYPRIRLDPSALQDSIHEGEGTPSPMMSVRDLPQAQVQYRLDTTNRHLPEDSHIHVSVINGARHVVVTGPPQSIHGLSLRAFTWKDLVIPVFHTSTGQDLRHGSDYELIISELVVIMTQLPAHCETATLISVAAHILRFNPSGISRFGVLTQHNRDGTDVFMIIRGAYKGTNNEVGYRPELFDGDSGHAVEYALNWLKEHGPKLVLTNRERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ64</accession>
    <name>A0A2T6ZZ64_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ64"/>
    <dbReference type="OrthoDB" id="5405453at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="381" mass="40563" checksum="4B9B5CD77062EB8D" modified="2018-07-18" version="1">MARADVKRGKEITPRRRVAIMTMRILGLQYHEIQARTGVAKSTANNIYCRAVRNATKIALDRKQHEVSELAALESQVVLGSPCTTIRSQELEVEIPEPLPAALLSQFPAAITTSELQHLGFRAPDLESGSTSLPRSLETAGLEALELGISQLQCVSNVEEDSLASRILGPEAILDNIQAASRESLRGGLEPGILGLRSTLDNIQGASGEDRLLGGIGNEIPELQDPLDSGLGASGEESFSGLGSGDARPQEGSESSGLGDEERRVREGFLGGILIFGAGSEGIVGVSEGDEDEITVTVPENIAGSSVSVPEISFLDLISAKALDSGSRSGRPQVLSSTEKDALVAFIKREFTTRRMVLVDIRRESGLSHLSDTTVWKALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZH7</accession>
    <name>A0A2T6ZZH7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B9Z19DRAFT_680055</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZH7"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 17 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015475785" description="Probable alpha/beta-glucosidase agdC" evidence="18">
        <location>
            <begin position="20"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="20">
        <location>
            <begin position="113"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="19">
        <location>
            <begin position="272"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="21">
        <location>
            <begin position="684"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PUU80897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="890" mass="99561" checksum="4E52AAAB2267E4AA" modified="2018-07-18" version="1">MATLTRRVAILVFISLASATIVIRPPAPDVNSCPGYKATYIEETSSGLTAELQLAGTACNIYGRDLATLKLQATYDSKSRIHVKITDTEEKRYQIPEEAFPRPHSEATGSAKSSDITFTYTTFPFGFTITRRSTGEKLFDTTGDTLVFESQYLRLKTSLPTDPNIYGLGEHTDSFRLPNVNHTRTLWSRDSYGIPQKSNLYGNHPIYLDHRESGTHGVLLLNSNGMDIKLKTVNGQSSLEYNVIGGILDLYFFAGPEPVAVAKQYAEVAGLPTMMPYWGLGFHQCRYGYRDWIDLAEVIANHSIAEIPLETMWTDIDYMYNRWVFTLDPERFPLDKVREIIDYLHEHGQHYIAMVDPAIAYQDYPTFNRGKQDGIFLKEADGSIHKGVVWPGVTAFPDWFHPNTSPFWVGEFVEFFSADAGVDIDGVWIDMNEPASFCNYPCNDPEADAIEQKMPPQRLPVRGPPRIIPGFPGTGKPTASVHSAERRVRKRQKGGSIDLISPLYAITNDAPLGLSDRTAHTDIVHYGGLSEYDTHNLYGAMMSYTTYEAMLARRPGLRPLIITRSTFAGAGKRVGKWLGDNMSQWDQYRWSISGMLGFASIYQMPMVGSDVCGFGGNTTETLCARWASLGAFNPFFRNHNGDTSIPQEFYRWPLVASSARKSIDIRYRLLDYIYTAMYHQSIDGTPLLNPLFFKYPKDTNTYSIDAQFIYGNALLVSPVIKENSTSVEVYLPKDTLYDFHTGKKIKGGGMNMTLTNIPFDEIPLHIIGGNILPFRSSSAYTTTELRTRPFTIVIALDECGEASGSLYIDDGVSIQQEAVIDVMMEYKSGKLSIKGKFGFKGEKDGVSVKIEAVKVLGKKRKDGRSGGEEEEEVFEKKVDVELVGNVEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZR3</accession>
    <name>A0A2T6ZZR3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1020610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZR3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZR3"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="397" mass="43187" checksum="F53E53C88A4C381C" modified="2018-07-18" version="1">MSTPASSTRGTSAETFTPFPPIPSPPRASSPPSPTNPAHSTTTDDRPALANDAVLKPSDPIPSTWNSRVVSGPEFNDLHHTPITISSLIDSMTNIGFQGSELARAVEVVDVMRTYVSPEGRRATIFLGYTSNLISSGLRSTIRYLVEHKHVSAIVTTAGGVEEDFIKCLAPTYLASFNLLGKDLRAKGLNRIGNLVVPNNNYCLFEDWIIPIFDKMLEEQDASNGELIWTPSKIIHRLGKEINHPESVYYWAYKNDIPVFCPALTDGSIGDMLFFHTFRSSPKQLVCDIIGDIRKVNSMSMRAEKVGAIILGGGIVKHHIANACLMRNGAEWAVFVNTASEFDGSDAGARPDEAVSWGKIKVDGESVKVYAEATIAFPLIVAATFAKDGIAEKHEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0C1</accession>
    <name>A0A2T7A0C1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1020247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0C1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0C1"/>
    <dbReference type="OrthoDB" id="5353931at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="399" mass="43501" checksum="BFD813A02407E3F1" modified="2018-07-18" version="1">MSLLQCPNEVLLLITRNLPAASLSTFAQTSRLFFDLAQELLLQHACSEKHAVLALSLAAANRDEKRVRYLLKNGRGFSIREENGSPLYGPLDSVIAYILQKGPNLIINHNLTYICATTPHHAIISGNTTLLKTLLSKGANANLKDPLHGWTSLHQAVHSENYPAIKALLENTPLTLNSRSTFGETTLHIASTLRSPRMCQFLLSHNADPTLQDFSGTTPLALSVSWSNLPTIKLLLNCTPSSTDTTTTNPPAGCGNRNEVINIQDRNGRTPLHLSAIYYTTPEIPHLLLSAGADPNIRTRAGETPLHYAATYTRPELVDLLLRRSPGVAVNSRDNTGSTPLHWATRSGRMGVVRLLKNAGADTGLVSKCGGWVGRGSGNDRVRKRSGVTFPRDNRVYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0X7</accession>
    <name>A0A2T7A0X7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1043207</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0X7"/>
    <dbReference type="STRING" id="42251.A0A2T7A0X7"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="253" mass="28382" checksum="D6149946EC9730C5" modified="2018-07-18" version="1">MGRQLQKKKNKSSIPKKSKHKNPRIFKVRPTGNALIAANWDHKQTLSQNYRRLGLVSRLGKSTGGVEKAFSAAAQQHKRLDEGGKKGDKKKLAPGEARIIRDEEGKIIQVIYGKSAEEALDSDSDSDKVGQEEGEEEGEEEGEEEEEEEEEFTGCAGGGGGGGETDIVKKLKAQAAVGERKNRKILCPGEMDWIFRLVEKYGEDDCEGMVRDRKLNVYQQTLGDIRRRVAIWKRQRAEEEKEKEERERGQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1H4</accession>
    <name>A0A2T7A1H4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_606722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1H4"/>
    <dbReference type="STRING" id="42251.A0A2T7A1H4"/>
    <dbReference type="OrthoDB" id="5406217at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="781" mass="86452" checksum="BDE38001C97A9636" modified="2018-07-18" version="1">MAFSRPHTSHGRPGQFQDGPDPKLQFDIPPFDPAETEFHNHVSDPRGEFNDRPRGQDFRPEIHQDNPPRHNSMPNSSLQRRASVGRGVHPGTFQGMPGTFPGGGIGGGGGDGRGRPVVIQHGHLPERRYVSFQKRTGKFWEKGSTIYDHIMMEISPEDAERRIRRHEESGKGLSTVFNGLAFHQQSHIGEAKERLNKAERDSGWRWVTSAVGKEKPEKPNATKTFWAIYSRLPKGRKGSQRHHRHSIGGPQPQMPHGEPRGRPTPQQRQHQAPDSFKVQPVQIPPPPRPSDFPGTDLPSPPGAFPQHLYGEEEPFGPGNFPAPEPPRVTPRPNPNFDYNDGPRIREVEPPIPGAFPQYQDHQQHYQQQQQGREPLPRPTIRSQLPQGTFGAPGPYSNAPGDRSSMPAMPGSMGGGGMGGGGMGGGGMGGMPNGMPGGMPSGMPSGMPSGMLSGMPGGMPGGMPGGVPGGAPGGMPNGLRNDHTLRDTDFRDPRDRDSRLPSGQMPRYDPGMNPHHSNSHHQGPPSSQPRRRNTSLTRSPDRLYNEHESFSTYREPRHLDSHHRLTTSGGPRRVRAATNPNHATTDFADWDLDKMRRTDRWVESSASGSSGVGSPTGSPDSFSGANGEYVLNPPPPARPRSPSIYDERERGREYHSSNHHSLPRSRSVRESRRYSSYNPSHEPQPLAIEYDYAIAGQNGVAGRGPTRYRTVYRDQDNRQYRRSMSRKRSGYFDSRDRDEYEYESADDIGNGMRDLRIGGGREGPGRQPRYTMYRGGMVSYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A274</accession>
    <name>A0A2T7A274_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_567158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000040">
        <property type="protein sequence ID" value="PUU81765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A274"/>
    <dbReference type="OrthoDB" id="5395290at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="486" mass="55279" checksum="9BFD8ABBB0850203" modified="2018-07-18" version="1">MMPALTIDHMIYTLSEIALHCNYHPPQQGSTRKFISEENQHRLQVLNLISLLFVTGGSGDVAAVSLHATSSKRIELCYSKNRPCTPDEKAYITELFTIATDPTSSGETKFSRLLKLVLRKCKDKIITRLHKLCNQLRFLDGPDVFLFVNLNSRAGAGHSPEATQCIAQIRELVGTERYPLDSSLIDFLKRWFQQLLCSLQPGSCFDMHANRHLVYDTIIISHLLANNPQAALIPDPTLVRPIRKLGNYRAAIWVTIEELAKLNVAGECRVSIKEIVPPPPNTQFPSDFLPILNECARDNGTTEVTKEDLSNAYPQEMWTLPRAREIPLQTSVHCECSLALSFAKSHLNSRIPATLIIGISKLPCRWCHEFLFAFHNSYPHITIHFPPFGGKLKSEWTLPPETPSEVVSGMHKRLNEEIKQVLARSIGTRVSHQIPLHPPAVIWRWGSETEDEVIGNQHRYCGLCIHLRVRPKWRYCWRHRRFGSHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2E1</accession>
    <name>A0A2T7A2E1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2E1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="16848" checksum="2559EE205DF15143" modified="2018-07-18" version="1">MPSPLSSPLPSRASSTSSILSSPSSQLLSELTEIDPPANFPLPIPAQCARKVRNKAISELLNLADGTPGPQSIVPPPRNLNQVLGWYTHLTLVQLLDPFLTQESVQNSCWLGTPIVTTSRLMQLWTYLNEITSSLDLQVSRMMMEDFTTTLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3D5</accession>
    <name>A0A2T7A3D5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1099254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3D5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3D5"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="539"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="783" mass="85835" checksum="DE2BCC42AC045F2B" modified="2018-07-18" version="1">MSHRRNTSSGSLSDTPPTPPPKFRRSLVVTTTTPPRSSTTSLEEPNNLTATTVVSTPPTPPPKPTLFLDTESVDPEYVPRVKSAASEVSPPRRPPPPTPDIQDKRFAKRLSKIPNRPTSVLEGLGIINIPSPTLFYSSFIPGASDTWCGIADHATDSPALTSRSYTPRQPAAQTNSYDETIAKGMSVLFDEEPGIGVVPLFSKRDSSSDLENTVVEETEMTQVAVEEIIAENLGDLSAAAENSIECLLDQLEATDSTKKTEEEKEIVDKTQDSKDVLRAYSMNVTMEKDPETITTGETNNQATTTLAPAANTTNQGSSSPKTVKSEGDEKPATSTTEKEETPRIDSSYLKAFRGFVKKSGDSDPFIHRMPRFDALQAQRICSHLRNDYPLVASGKKAKSGSPNGVVTATVRQREAEEGILTSLWALMALRWMNFGRVVISPGHETLLAASAKRLTRRATTKMDQRATQMLENVSSGVHLGSHERRRVLDLGGAPIADWGWHCAYDYPKAKVYTVTTGPRPKQQSEGEEKAAGASDKCRGPQNHRPLVVSKLWKLPFPPNHFDVVSARNLYLTLKATVPENSPNLGMDEYDLCLEECLRVLKPGGHLEFSLFDHDIVNAGPLGAELAAKFAKGLESKGYDAAPTKRWVSRLNRAGFGEIKRSWIFLPMSPPSAKPKVPSKGEMQLPPHESQDLEMVKEEVRRKLKAWEDLGVENGSIENVSPVTGLVGSWIWEKWMLKTEGEGGGECDLAIDTIGDVLEEGREKGSGWRCLVGWARKPMFAGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3F2</accession>
    <name>A0A2T7A3F2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1099326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3F2"/>
    <dbReference type="STRING" id="42251.A0A2T7A3F2"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="326"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU82230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="467" mass="50658" checksum="CB477147BF8A7E02" modified="2018-07-18" version="1">MPMDRSPDCMDLDVGDDRRETAWWEDLTKNSVRMQELVGNLNPACFPIDETRPCSEVEIALERMYYDLHPSHARGAHLLTFRTACAHIIPIINISRQNAGGSAGGMGAFTSTMSSFLREGYPESAPFNGEALHSRAGDDAGDESSIPSSHGGAGSLRSGVPLSLHERPRTGDRSHPCDSQPHTHPPYGNPATPTPSDSTKCSPGRSNSGSPHPSGGTDSYLSADENIRSYPFSPALTSPRRSRANSHSRSVLNQGQPPIHTGHHFDVPPPRSSNGTGPGGQHKCDACGKAFPYLSKLKDHKHIHRPDKPLPCNYPDCLKSFKRPRELQAHRKTHSRKSQFVGIPAQPGIPRDPQRVPHPHPHPPAPYALAPPRQPPSSTGYDGGSPTSELLDSDRTSSASPRESTFSRSSTPASSHTDGGVAILEPLVADTLAVDRQREVDRTDTEQTGISDRLHERLNRQLFPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A418</accession>
    <name>A0A2T7A418_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1074961</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A418"/>
    <dbReference type="STRING" id="42251.A0A2T7A418"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="373"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="504" mass="57374" checksum="0FF368C4EDBF4BAB" modified="2018-07-18" version="1">MSNNDIYQTPLASRYASEEMAQLFSNKTRFRTWRQLWVWLAKAEKQLGLPISDEAIVQMESHLDLTDEDFKVAAEEEKRRRHDVMAHVHAFGQVAPAAAGIIHWGATSCYCTDNADLLFLRQGLDIILPKLANVIHKLSNFALEYKDLPTLGYTHYQPAQLTTVGKRACLWIQDLLWDLRNLTRARSDLGFRGVKGTTGTQASFLAIFNGDHNKVEELDRLVTQFAGFEYAYPITSQTYSRKVDADVIYAMSSFGATCQRIGGDIRHLASTKEMEEPFEKDQIGSSAMAYKRNPMRSERMCSLGRHLANLCKDALDTYSQQWFERTLDDSAIRRIDIPHAFLTTDVLLRILDNIAGGLVVYPAVIARRVREELPFMATENFIMRMVALGASRQDTHEAIRVLSHQASAVVKQEGKDNDLIERIKKDKFFEPIHNEIDSLIDPRSFIGRAPEQTVKFVEKEVKLALEPWIGAGMERAIGLLRNFEFLKKHEAGWEKGPVYMITAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A428</accession>
    <name>A0A2T7A428_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4 transglutaminase-like domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1074914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A428"/>
    <dbReference type="STRING" id="42251.A0A2T7A428"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="497"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="557"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="626"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1146"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="857"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="878"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="961"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="981"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1186" mass="129699" checksum="0EFC212E9E4B215C" modified="2018-07-18" version="1">MAQKRPASNPPPGPGQPSSRLRTPKTTATKGASGAPGSSSVPGGSVGSPEKVTATAAGVRGSGSGVGSSAKRLSAISGSGLERGGKPVPASGSATGKLSGSSKKAQVGAGSPGAAQPIPIESDTSVDLDEDDEDGIKWEDVDLGPQAITNFLSSASNENPAQASLSLTLGGKDKKPARTVRTITAVERRIRWETHKMHILCLLHHVSLRNRWCGSPEVQDNLSPLVKRKIRQLLIDNPNDQPFRRSLLFLEGLRALSDIWVENFRVIRAGLSKCRWAGPENFIHKGGDPPLGYKEFVIVSRMRKGSRDIGAQLFCAMLRSIGVTCRLVCSLQALPFTFSSNEPPMKILADATTGSDKGIGYISKTWLWNCRQNEHGIRQDERGWPVYWVEAWSVGGQKWIAVDPFATKTVGKPSVIEPPVQVPGNLMSYVVGFEGDGDCTDVTRRYAQAFISRTRKVRITGTPTGEIWWDRVMATLATGAHSHRRQLEQTELTNKALHEPVPKSLKDLKGHPLYILERHLKRDESFKLLRKCGTLTTGFGENKKTEPIYRREDVIKLRSLENWARLGRTVKPEEESKPIKYVKAVRLPSTKLRNARSGDVEPEMSALYAESQTELYVPKPLVNGRLVKNKFGNIDMFVKSMLPEGAAHLPQKSIDKAARLVGVDFAPAITDFEYRHGYAYPVATGIVVAKEYTEAIEAVHEGLVEAQDEKAARDRDMKALCLWRRFITKIRILDHVSRIPEEQEGAHHPMTMMANNQSKAVEKGVVEVVEADEGEFGGFRGGFYPVSEESEPPISTKLTKKSQSLKQRYKNLYASPSLTFAAKTAGKKTAKSKSKSTTAAKAKASAGKTRRRKVAIESDEEEEAEESEASDSNSFSRTQRRNPRSRKFNYKYNFDADSSDDYGGDDTAASSGGAGGGFLKQQENKATPRRSTRLATAVNKATPVKYTLDEDDDDEDDPEQELEKQQQGEEKRASGGFLIGSDNSSSELSDAPSNLISEAEYEVSVSGRAIESNPTLREEGHGSSRLFTEGSEKQDDEGDDGDDEDERGNESNDDAESRRAVGMFETPHHRFSNNGNLSKTDHVMRDARPATGTGDGAVNAAKTDQEMVDYNGGGDDHNYDDIVVGKSLPVENEAVVGPTAALPDTVAGLEKMHREEHTPSDGGSSPMLSEDPEDRDNADLDWCNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A445</accession>
    <name>A0A2T7A445_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1074578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A445"/>
    <dbReference type="STRING" id="42251.A0A2T7A445"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="8"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="458" mass="52949" checksum="FFEF16D5CC4CD143" modified="2018-07-18" version="1">MDAKLLKGTKFPPEYSKKVDMGKVNLEVMKQWISGKVIEILGNEDDVVIDFVYSLLEEERIPDPKKIQINLTGFLEKDTPAFCKQLWGLLLSAQSNPQGVPMELLEKKKEELRREKAVIEERTEQQRRKREEEEAREREIANVRERERDTRRRAPQSTAGASLSSKDTRERGGGDNYVARPRPPSPRRRSTDRSDRRERRPPHQRGGGRRGGGGDRFRGGETDTYIPSRRGYNRRDFDNSEDRSYNRYGRSRSRSRSQSRNRRDEYRARRPSPHYSNSPDMRRGHERQHQRHRSRTPDYSRGAGGGRSNRRDSRRVESVSSRSSSSSRSSYASTRSPSRSPPKRERGGGRRERSASRDRVDRREKRSSRGYAEETDSWRRRRHESEERSGRDARTSKRRRSLSSDNDDSKGSKNRRGSPSRARDREAKSSTATTTGTKAVEKDKEVGDSSIIETPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A449</accession>
    <name>A0A2T7A449_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin reductase</fullName>
            <ecNumber evidence="8">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1074573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A449"/>
    <dbReference type="STRING" id="42251.A0A2T7A449"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="10">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="351" mass="37772" checksum="65E934D1E0D8D1D4" modified="2018-07-18" version="1">MHSKVVIIGSGPAAHTAAVYLARAELKPVMYEGMLANGIAPGGQLTTTTDVENYPGFPKGIGGQELMEAMREQSERFGTTIITETVSKVDLSKRPFKYWLEYCEEEDPNTADALIFATGASARRLHLPGEDTYWQNGISACAVCDGAVPIFRNKPLAVIGGGDSAAEEAIFLTKYGSKVTVLVRKDKLRASNIMAKRLSAHPKVEILYNTVATEAKGDGKLLQSLAIRNVATGEARDLSANGLFYAVGHEPATALIKEQIDCDEDGYIITKPGTSYTSVKGVFAAGDVQDKRYRQAITSAGSGCIAALEAERLLAEEEEAAPEPITFVVSLVSKQKRVRLTALPHHTELIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A475</accession>
    <name>A0A2T7A475_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane peroxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1074676</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A475"/>
    <dbReference type="STRING" id="42251.A0A2T7A475"/>
    <dbReference type="OrthoDB" id="5586090at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="322"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="552" mass="60773" checksum="413FCDFCB5778BA8" modified="2018-07-18" version="1">MSDEPSIGAEPLTDLHPTPSTKDPNPPTFASFAPPSCSPAARSTFQVHQKSPLLAATPPRITRALSQAFPYLSGLNWVAGLLTWTTKDPWESFLVVAAFWAAVLYGDVGLRWAGNVVAVALLVLGMFLRRYRDEPAPTTLDEILETLSSLTTRLNIFFEPFLSLTRFLSTTVTATTTTTRPVLTTLFFRILITTPIWLFFAVYPFQVITTRRVALATGTLILSWHSRPAKVSRTILWRSSLIRAISSYITGLTLVPLPSPPPLPPRKARKSSMSNRDVNPATASSTSVNSLTASPPKRAPTLQIDPSKSTPLTASTAGASPGVKFTFAIYENQRRWLGVGWTSSLFAYERAPFTDEHLQPCPQPEEFALPETPAGSDVRWRWVEGEEWRVEGADGHGKKSKGQEVKDKLGGSGEVGQGWVYYDNQWRDGRRGVDGWGKYTRRRKWYRNAELVEDLGSDTSDSEGEGEVGAQEEEGATEATFSPLASGGDGNGKQRYRRTEHDEDEGDISTDEVPDVIVTLEEDGTGEEKEKYIMEKSVVSGNGVARPPLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4C4</accession>
    <name>A0A2T7A4C4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1074736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4C4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="7336" checksum="3CCEF8C8B6A5691F" modified="2018-07-18" version="1">MESDHRVNGKNEAFVDPHHLHEAVVAISDLSRGFVKLNPISAIKSFLSKVPELRDGADTNVSSLEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4T7</accession>
    <name>A0A2T7A4T7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1074343</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4T7"/>
    <dbReference type="STRING" id="42251.A0A2T7A4T7"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="251" mass="27342" checksum="F53CDB6BF2E18FA7" modified="2018-07-18" version="1">MSMRLTKGLAAATRLRPTAALLPRFVPAINTAAAPVTTHRHQSTGTPVPAEDPKIKAQSILDALPGSNLVSKTAILSSIAGLSVAAISSELYVINEESLVAISLLTTFYGIARMGGPAYTAWATTQVNKVRDILNSAREDHTRAVRDRIESVQQMSGVVGITQALFEVSKETARLEATAFELEQKTAFAAEAKSVLDSWVRYEAQVKQREQKELAESLIAKVKKDLENPKTLNQILQQSVQDVERIFSTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A556</accession>
    <name>A0A2T7A556_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A556"/>
    <dbReference type="STRING" id="42251.A0A2T7A556"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="11622" checksum="D6C3E89A2581EAB9" modified="2018-07-18" version="1">MTSLKNIGTTVVSEDVLNAAKRDFASERVSDQQTVQSIRHIFTTPPSTPYILGPHSAVKVATSLRLIKASQTAGQENVHHISLSAAHPAKFNPPPHVPTISNTGTTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5A5</accession>
    <name>A0A2T7A5A5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1120042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5A5"/>
    <dbReference type="STRING" id="42251.A0A2T7A5A5"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="352"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="452"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="524"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="601" mass="63066" checksum="9BBC5E568ECC0293" modified="2018-07-18" version="1">MAKEKPSAKPAYNGKANKKDVLKSIRSAVITKKSTKPTKPKEFALKAAAAVSGHKKAIESNKSAQSKKVTEPKRKAKAPTPPSSESSESEGSSESEDGSEAEDGSESGSGSGSDDSESESGSESEVEIKKTEIKKVEAKKVEVKKPETKKIVAKKPEAKRPEPKEAVTNDSSSDSESDAAGSDSDGDSDSDSNSDSGKEALKAKAVVKKAKSVSSSDSDSDSSSDSDSDEEETPLSKKTTPIKAANGTKKAIKAESSSESDSDTDSSSDSDSGAKVRSIKKAASDSESSSDSSDSESDAKLKSAKKASDDSDSSDSDSDQAEPDSKKRKATAEAEVTPKKVKTGSSTEEGGRNLFVGGLSWNVDEEWLKGEFEQFGEIATVRVITDRESGRSKGFGYVEYTTHEAAKKALEEMKGKDLDGRALNVDFSTPRPQNLRPDRSKSYGDQRSPESDTVFVANLSFEADEQVVQTEFEGFGNIIGLRIPTDMESGQPKGICYIQYDRVDSARKAVEGMNGALVAGRAIRTDFSTPRDPSSGGGRGGGRGGGRGGGRGGRGGFGDRGDGGGRGGGRGRGGRGGGRGGFQSQNRGGFGDFQGKKKRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5S5</accession>
    <name>A0A2T7A5S5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5S5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7923" checksum="76AEE47AABE22470" modified="2018-07-18" version="1">MVFQSEILGYQDPCVPQWHSQFESIGAKSLTAIRNYVKEVGEGEFPGDELTHHLFTGQDLDNLGLDSLVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5U9</accession>
    <name>A0A2T7A5U9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1061262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5U9"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="23345" checksum="7AE18E789F089750" modified="2018-07-18" version="1">MDTCGEQEMVPRFGFISPAFPSYQDNTVPQTINDPTPIHAFSPRNTSTRPQIIISAIGVTVSGSGKGYFIWGASGTGVSDAERSKWVVVLALVTQPPGEESGHKRRERNKAILRSNLILSPIQQKMASLDTPGFNNTIMGQTEAMAGICVCPRASLSYREGRLLSGIIYLHSTTNSITIDTSLKNPWHGDFWRGLIAGVLLLKDLKAPEDMDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A665</accession>
    <name>A0A2T7A665_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A665"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1163"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1340" mass="144933" checksum="02523660D52AD03A" modified="2018-07-18" version="1">MNRPTRPDCLDLQQQQPHHQQSSLTHQRSRSNGSIDYPLSSHGSVISMSYPLASVTPESAYIAASAATGIVTSNHENFLQSEGIVSPGSPTILVTPPSLRLINQFLDFLLYEFLSSAKSTSLRLLKPAVEEVLRSRLANEAISGADQELASYLGGGDGEDDGDFGEPQETTGAWDLEGTWKKTRLRCMVYSSLGDLEEDDEAVYSGVGLEGSVGAQQYNDHSAIPDIVSPAVAIWLTAVLEFVGEQTLLVAGHAAINRFSRELPTNETGETTDATERPIVEELDTEKVALNPSLSRLWRQWRKRVRGRSSISIPSIQRHERRASTSSRTSASSLATGNILRDEPSAAKGTSEGDGAPVVGMDKELEVGDDAATLEAKKEASLPPIVEAAPPLTDGDAERFESRKVEPMSVDELMELEIADRLERRRPQSLIVLPWTTESPFVTLAEDDREQIDPDDLEIAKSEVETGESAETDQAFSASPEEQQGWPAEPDKELESVVETYETYEQSGGSIIGGGSNSEVMEVMQAEREFSMDEAIEIESPETAENAVSVAGNDEDFSGEIGVARTSDVATPACLSPSRARFEEVEETPIHQPQQEDEVEGAPAGPVYHATAGSSGAESTHSAGIVETPRSAEDQPPPVPEKAASRRASIAPAPDDHTEAADSTVISGGKTPVVAGRRGSRTETSTHPAENLTGNENSSHSKKGSSTSSKHSQYSQLSDRKIGQLTLVQPSSSSCISISSERANGVRGWTPPATPDKSRRSSSFSKTQRPIYSSGSTTSQSSAKFKSFVTWPVGNAGHSKVPESDDESRSSLHSERQSAKFANMDERERSFEELISSNDTIHCTITPDPIRRIEGSSHSKTQTADLADFLRSTGPDGAERPRTVTPNKSGSRPSSARSKAIIPKDPTSGDSITLAQMLRSTASPPFTSSTFAGSLPPPRPDATVQTVKMPNLFTPVPATAPPRVDSFSLTPPSGIILPTVMKRRSNSLSTTHSQPRNRLVARDASGSTSSASTSALADFFRNTTPPVDGEQIVQRRISRSVAPFRNTMDSDRFEATRDPARTEKVDSAANGHGFAVNSAPEDSLQSAFSSSTALLGGTSERAHDYGSIPSTSSVLTPQRKQTRVRDPYTIEFDELDDDPDLGGLGLVVLGGKQEESLIDFLRNVPPPPQPPTPLEDPKDKMVQKKNSSVSLIGRFGRSSVRKNSNADRVIPMVPQLPAQSDGLGKHIPLLSDTDHMSPHHSSNTSQPSLLIKRHNSYRPTSDLREHRMMGNSDMKPRIQYQARGARIERDDTDSLVDFLKYTPPPLPTPTDVSPSMHKEEGGLPKFKLSFGRKLKRSEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6E1</accession>
    <name>A0A2T7A6E1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6E1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="75" mass="8341" checksum="E7095F201F122068" modified="2018-07-18" version="1">MMPHNPSPLFLNLASMVVVLVLPMILLVFRHATSLHKCICTLPFVPEYPGSRKTSEDKDGVYAKELDRQGVSDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6F6</accession>
    <name>A0A2T7A6F6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1016148</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6F6"/>
    <dbReference type="STRING" id="42251.A0A2T7A6F6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="435"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="696"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113464" checksum="F634BD85EC1AD853" modified="2018-07-18" version="1" fragment="single">MPSKYKPTRDRKQRRVPKPPRNAEDNTSEAAPPPAAVPSDPNAEIIIPLTKEQKAGKRKADLLAEARAENPGMSGKKLKRFNKYIENKLKKEEKAEIIAKLAAGASSMDTGLLRSTKELGRGRETRKERVRRAVREVKAGVAGEESLEVVFEERIVRDPTELEVAIPPTAEPEEAVKVEVEVKGEKGSTEKLPIVPAIAVGSGLKRPLGTDKNGFPIIKRVKKSVQIRQERLMEMIRVMEGEVGESGSEDEDDSGESDESDESVEGEDEDEDEEEWGGIADDIDTVPNYGDSAEEGAGSTESGEEEEEHEDEAEISGSEGYGSEEGSEGEGDGGDEGDKPVSRLRRGQSERANAFKAWALAQRKQVLNGGEPEHSMPNLLELKPKVVAIPKAAPAPPPSPPGGVKKASFVTVQRPIEIQTARLALPVVAEEQRIMEAISANDCVVICGETGSGKTTQVPQFLYEAGYGSPSTPTPGLVGVTQPRRVAAVSVASRVGEELGPGGKEKVSYQIRFEGTVGSNTAIKYMTDGVLLRELSEDLLLRKYSAVIIDEAHERSINTDILIGVMSRVLKLRKELAEKDEAKSLKLIIMSATLRVSDFTENQRLFPVPPPLLKVEARQHPVSIHFSRRTVSEYLEEIYKKVCKIHRRLPPGGILVFLTGQNEIIHLLKRLQKTFPFKNEKGGSTSASAPLSAQISASEAVVETEDMEFGDTSKSDSYDSEEEGSNLGNGDDLGEEMSAEDVESPLHVLPLYSLLPTKEQSRVFRDAPEGSRICVLATNVAETSLTIPGIRYVVDCGRSKERNYNKTTGVQSFDIGWISKASAAQRAGRSGRTGPGHCYRLYSSAVYERDFPEFAEPEILRMPIEGLVLQMKSMNIDTIANFPFPTAPDRPSLQKSERLLEYLGALDPRGALTEPGRIMNCFPLPPRLSKILAIGHQHGCLPYVIAVVAALSVGDVFIPEHQLDIHEEADDGGAPRNTETALEDTQRAKRRKEYYRAHRTFSSLDPTSDVLKLLSAVCAYEYEKSPTDFCEHNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7B4</accession>
    <name>A0A2T7A7B4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7B4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="235" mass="25773" checksum="AA4E1F585F27DF3E" modified="2018-07-18" version="1">MLSLALPVFCGMLSPQSDEGLESSSTTQLRDNQLLDNFLEAAIESSSIGATELPTNSSDMNEDTSIEESDLLNSSLVAAVETISIRDPKLPTNSPDASEDTSMQESQIMDISLLVIDDTQDAIQDVIHDTSIYDSELPDYSLVVIEVVFNILYFKNANISMAIKKALLSQIAQMTDKYNLVSGLKVSRSIWPGMGVVDQRKKLTLLGKGRKFEDINREDEISLSQVFGEGVLESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7E6</accession>
    <name>A0A2T7A7E6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_893169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7E6"/>
    <dbReference type="STRING" id="42251.A0A2T7A7E6"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="266" mass="26959" checksum="CE00AFAFB39EAFA5" modified="2018-07-18" version="1" fragment="single">MSSPLEEDSETPSSPDPFGDSGSIFATTSPPSQPHRTLPSFRSISDSQTTTQSPNPLGPLNAARRPGSSQVPFASMQSVGSGTGGLPKDVQARLQAFQASRRGAPPAAKSGGTPTLQTGGVSPIVGSMSPTGAPFSPVGGMTGKPGNRPTAPQNWTSAPAVTGRMGPPKMSLMERRRKQAFPGGLPPVPGAVSPGPLSGGNPVTNGGSGAAPTDGVQGSLFDKYSEYVDAKTGSLRFAGKAVLHSKGVDFSSGSSFNISLEELDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Q2</accession>
    <name>A0A2T7A7Q2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1071578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Q2"/>
    <dbReference type="STRING" id="42251.A0A2T7A7Q2"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="86"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="235" mass="26173" checksum="EA489F77FF1B58FB" modified="2018-07-18" version="1">MSITLYTSRLCPWAHRAHIALSELGLDYTEVPIDLTKPREPWYLEINPRGLVPSMKYNDQIITESAIVSTFLTDLKENHLVPFPGTPEAALKRAKINFFVDTYIGKAQSLVHSVLTTTDAATKAQRANEYVDVIDKQLAPLLADAKPFFGGSSKLTLAEVLTASFVIRLYSYAKPGIELFPQEALDRIRKIENWQKWADAVMAHESVVGIYKEEDVIAGLKRLLAKSAAAAAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A836</accession>
    <name>A0A2T7A836_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A836"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="6997" checksum="3F203F1FC2760293" modified="2018-07-18" version="1">MGLESPSDKDHLCLEDYKISVNIMDVSGERVLHAAALEGWERVMKVLSSQPDTDVHESDNLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8N1</accession>
    <name>A0A2T7A8N1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8N1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="146" mass="16963" checksum="739D370BDA4770D2" modified="2018-07-18" version="1">MASIFIQPSRRLALRSGTRAFSMSRTSLLKPSASLYGFSIDDYDAKPKSDLDISKEILQKRMDLGILQLQMKEIRRSIFRAKVNRRRARKMRFIDMLPDPPGFLFYTEWNRGQNSSALFYLPLPPHGAFVQVIFRARLPIDVRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8S9</accession>
    <name>A0A2T7A8S9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome oxidase assembly protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1070663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8S9"/>
    <dbReference type="STRING" id="42251.A0A2T7A8S9"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU84139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="507" mass="55134" checksum="775B3B3748D896B2" modified="2018-07-18" version="1">MPFSVATTRGIWVNIGRACLPRTPALGLPRPLLGIAKSKSASPSILPRLRNISFTNTSRSTVTTSTLTSTTPPGKPSSPLGTLANTFARNSQNLKAGAKPQPFFPDISSPTVGYWLLGSAGLVFGIVVLGGLTRLTESGLSITEWKPITGALPPLSPEGWESNFSKYRNSPEYRILNPNMTLDEYKFIYYMEWTHRLLGRIIGLSFVLPAIYFVARGRVSQRMALRLGGISGLIALQGGIGWWMVKSGLKDDLFQQPGAHPRVSQYRLTAHLGAAFAVYAAMLWNGLSVLRENRLLVPDPKAAIDEFVRLSNPALRPFRRLVAVIGALVFITAMSGGLVAGLDAGLIYNEFPKMGNGYIPPLTELMNPFYARRPDHSDLWWRNMLENPTTVQFDHRCLAISTFSFIAAVFAYSRLNPAVARALPKNGKKGITGVMHLAILQVLLGVGTLVYMVPTHLAATHQAGSLALLTSAIVLASRVWLPRAALGAARRRLQAVAGKKVGGKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9I1</accession>
    <name>A0A2T7A9I1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_5237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9I1"/>
    <dbReference type="STRING" id="42251.A0A2T7A9I1"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="738"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU84375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="838" mass="93436" checksum="BE58C7139FB1DE41" modified="2018-07-18" version="1">MKFGEALPQRSVQEWLPYNLDYNEIKQLIKRYTTGKPLVKSPEAKTDFEDEFFNILMDQLGRIDLFVKSKSGEVDRRIVRCKRQVAALRRRDTEDTTLPHIRRPGRSTKTEQEVERVSYEVQCLSRFVNVQRTGFLKLLKKYKKWTGSSHLLNRFLPILKSPTAFYKVDFEKNVLELSNLLNAIRNGLDLPAAVPPPPQIVTQPKRIRGTGQEDSQERALSIETVLSQKAIATTEGRAYLDTALATSALGDSGGGRATFWVHYDHLIELQVLLLKYLTLQTSPIHNAPPTSPSRKDSIGTLWKDDEIGVVLLDDLDSFSDIQSSATVAEVSKACSRTAGQVRWCCRDSDAVVVVSNTSALDLNRIAGHDEEKLEVRMKRKQIEELLDTGSISSKANISHTTDEQRDTGVEKLEEWLAKHKNITPLAKLLMKRIRFAEPPEGGRVWALLDWDIKMTKVQQGTNWLTGPEEEDGPGFGSEGRSEFPHAVLEVQWEGQRVPTFLHELETSHMVENVRGFSLDVHAVSVLYRPTNMTPPFWLSALQRDIRKTPVHTPRHSRRSSSHMMFASAASKPNSNGTSATMAHDFTDGFDSSTTAFSHTAPTTLPRAKSNNRSSIELISGERYWSEFNDDEDSEEPYTILIKRGEASDDECEDEDVSLSRFIRKSVTSTSHKFQALFTTSPKTPGERKPLLRKPSVPSSESSSEVDVEVGTFGIGVSSRAHYNTFSRPATNNAPLSPAYALCLGSAVVILVVTLILSMNSSIAKHKHKWRRGHFTLDLEVCGAVLTALSFASIGLFIFLKGRSRVGPAHQIFAWGSFGAVCVGSGVVLAMVGNREVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAB1</accession>
    <name>A0A2T6ZAB1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1137606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000537">
        <property type="protein sequence ID" value="PUU72430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAB1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="239" mass="26658" checksum="1EFD1B065D6B8F11" modified="2018-07-18" version="1">MPALAEPDPDAAALFNGFLSSLSSFFKAKRPFRRPIIPTSPEGDDSVELKTWDRPFLPPSWDSSSDSLSPSPPFPAPAPPPTTPVEPPTGWQLEPAGPEKEPWWRFPGLQKSDEYKELVSNQWNDMSKRSVQYSNHAGAAISKALEGDYRPSYFQELPLVMFVFLVTMFAGAAALSAVVRTEKRLRPRLTQCLEKLEDDQHMYAALYSAMYCAVIFSLLTLLLLGVFGLHQLLLLAIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAB3</accession>
    <name>A0A2T6ZAB3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1197591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000552">
        <property type="protein sequence ID" value="PUU72386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAB3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAB3"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015402453" description="DUF1479-domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47260" checksum="2E8140ADEE1D34A1" modified="2018-07-18" version="1">MLSRIKLLVPNLALATRGVATTATRGKIGGDISSVFPSLSGIAPPPLPGRYAELKRLFTAGRERVLAESWEKLLLDLEKETAVVKRFGSDLIPQVEFKDLASLSKAKIKDIKKRGVVVIKNVLPEKEALSMKESLKEHIERNSWAKAFPADSPAVYELYWSPAQRAARAHPSLIASQCFVNSLWHSSLPPSMVDTSMSLPYADRFRIRQPGDAGFALGAHIDGGSVERWEDLEYSLCYEKIWTGRWEEYDAFNADHRVHAMMDLYDGAGSCGVWRSWQGWLSLSTTSPGEGTLLVNPVLKHATAYTILRPFFTPSTPPTISTTPHFPNSVQGACQEFNNSTHPHLRLDDVMTHVPRISPGDYVFWHCDTIHAVDRVHQGASDSSVLYIPAVPWTVESQAYVERQREAERRGVSPEDFPVGVGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAI3</accession>
    <name>A0A2T6ZAI3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_660378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000517">
        <property type="protein sequence ID" value="PUU72507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAI3"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="9">
        <location>
            <begin position="41"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="736"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="815" mass="86769" checksum="73F9897CA7160719" modified="2018-07-18" version="1">MAWQSPSAHNSSPDGNNGNGGLQGNGANGGSGDGAVGTEYTLQGVMRFLQTEWHRHERDRNSWEIERAEMKARIAKLEGENRAANRLHQGFLTRIKMLETALKKERTSKGVEGAEKDGQGNQKAVVENLINAKLSQQSSPLGESTSLYRAEAARNKSRIYLEKCLQEITYLLTPPNHPPPQHQPPINMESILQQHHQQQQQQQQQQPQHQVLQQPSPSPNHQPPCPPGQAGNHLGNTGMLSGHQSYPHSRASLSRPHEMGGQQTSFAQESQTQPQPQINIPSGSNEQSDEALQQQNTFSSSGSDFGNADTNPFSASVSAVGENATGSSAPSDTDSWDFDETTRVGGSDPEAANSHPREVEQNSSSNHVGKANSVNRRKLSASKHRSPSELRDLAGIVTSATVPGFDSGNFKVKFALRGHLDVIRAVIFTGGGTANEPEICTAGDDGVLKRWLISGSYGLSMGLSDMDIQSHFTHRGHSGMVTCLAARPPTGGSGDEGASSAGRWIFSGGQDSTVNVWEAGRVGPKATLVGHTDVVWAVCVLPSASNVLGSSDSFERVLLASGSADGTVKIWSVTPPPLPQPHSNAGSMRGSFRDTPSSAVPYVNNVPFQYSLISTITREGIIANPTCITPMSITGETFVVSYDDAAIIIYDTASGEEIVSMMSQETYDGTPASGVNAIVASTVNLESGIEAGKEDEALMAGATGLKGGVGGMIISGHEDRYVRIFDANSGQCTYTMLAHPAAISSLALSPDGRELVSAGHDASLRFWSMEKRSCTQEITSHRLMRGEGVCSVVWSADGRWAVSGGGDGVAKVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAM4</accession>
    <name>A0A2T6ZAM4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000529">
        <property type="protein sequence ID" value="PUU72474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAM4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAM4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="486" mass="54174" checksum="F9B7AF3753F0332F" modified="2018-07-18" version="1">MFTFLSYRHATSLLHFRRNPFAFTDTNIPFPIDSNIQSFGAMTTEQDTVSFVPPSDRSAYRNIFICNFHHRGTVLGGLRVAEAFSQSLTRFGGNNGETFIERLGRLSTHPWISAILVVWNVIIKAIFLQTIDGDLLKLVYHLSRFRMLPSVEPLMWLKPKPKLMLFPTLPPSFSLLPSFTPPLSLTPTVVESPAANSTTTIPVSPDSPGTDASRIRRAPKAQGQRVGFQLETREARKAICEIEGLDDKDLDTIYKGPASSAIMVQSEMGEPIYKSGSNAFGSQLDVKIAQMGLLSDCCRMDSMTYDGKIENKEAYCSDNKPKISPEPPPLSPSSAGMKGRVDAFQPTNRLCPSKKSYNLNAPSTNAKHSIVNLLRELVCRQTKLAISSWSPFISIIEKLIIWASSTSMKILPGPEIDPLTGMAQLVPAGFLCRHPYCGNHPTFDVADAMWRMRRALELDLAMSKECGVDAVFQYWHDKNIYFKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCE7</accession>
    <name>A0A2T6ZCE7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B9Z19DRAFT_1069200</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000407">
        <property type="protein sequence ID" value="PUU73171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCE7"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000012">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000017">
        <property type="entry name" value="Chitin synthase ChsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="878"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1187"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1569"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1610"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1640"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="20">
        <location>
            <begin position="1"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="941"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="21">
        <location>
            <begin position="1800"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PUU73171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1858" mass="206269" checksum="C5DF56680FC85AC8" modified="2018-07-18" version="1">MAQQQTPQSQPSLPSLPAHLQSDTHITAHLASRFHLSLPTANISSQALVSLNTYTSPHAVSSDLEAIAGRMWRRLGGRGENQAVIFLGESGSGKSTLRSHLLSHVLSFTSTPLSQKISLFTFLFDSLTTTKSLTTPTASKAGLFLELQYDNISQTLIGGKLLDYRLERSRVAGVPTGERNFHILYYLLAGTSDAEKAHLGLNNSATASSNRHSGDISGRGGQKRWRYLGHPTQLKVGINDTEGFQHFKTALRKLEFPRQEIAEICQLLATILHIGQLEFTNGHATHANGEESGAMEGGDQIVNVKNKDVLGVISAFLGVSTEALENCLSYKTKTLNRERVTVMLDARGARAHADELARTLYSLLVTWIIESANERICAVEDAVANTISIIDFPGFTQVSATSSTLDQLLNNAATESLYNFCLQTFFDRRAEQLESEEVGVSATSYFDNSDAVRGILKHGNGLLSILDDQTKRGKTDGQFLESLKKRFDSKNNSAITVGSSASVIPGAARSFTIKHFAGEVEYPASGLLEENGEIISGDLMNLFRGTTSTFITELFSSKAVTTVHHPREKTAIMQGQIASKPLRMPSVMRKRGERPVRGAAGNTKGSAPDPTTEINTISSPDQGAAAQFVSALDTVTRSLSGTNTNPYFVFCLKPNDRRIANQFDSKCVRTQIRTFGIAEISQRIRNADFSVFLPFGEFLGLTEAENVVVGSEKEKTEFVVEEKNWPMNEARVGATGIFLSERCWLEIANIGEGGGSAARRSMAGAGFLDSDDRSDPLTPVGEPGGGNGGLFGGSDSRLRLIPSHGPGGLGTHIYGTGDGKGGYFSKADDLRSEAAASAFHSGDMFKNFDTPQQMAEKGQAAREQEIEELPVTAGRKRWMFGVWAITWFIPDFLIRWIGGMKRKDIQVAWREKLAINFMIWFMCGLAVFFLIWFPSLICPRQNVFTLEELENHNGGKDHMQKTAYVAIRGVVFDLTDYAPSHYPPLVPRKNIMAYGGRDATSLFPVQVSALCDGVEGSISPYVSLDFQGTNATADRGLDKNARYHDFRAFTNDSRPDWFFEQMMVLKANFKKGDMGYSQKYVKTLATKRSQAVAIIGDRVYDLTDYAVGGRRIDVPSNGDSIDLSQIKVDFMDTMVVDLFTQRSGQDVTKYWNALNLNADRKHRMKVCLDNLFYVGKVDTRNSPQCLFAQYLLLGVSVLMCSVIAFKFLAALQFGRKNMPEHLDKFIICQVPAYTEDEESLRRAIDSIARMKYDDKRKLMVVICDGMIIGQGNDRPTPRIVLDILGVSENVDPEPLSFESLGEGQKQHNMGKVYSGLYEVQGHIVPFLVVVKVGKPSEVSRPGNRGKRDSQMVMMRFLNRIHYNLPMSPLELEMHHQIRNIIGVNPTFYEFMLQIDADTVVAPDSATRMVAAFLADTRIIALCGETALTNAKHSFITMIQVYEYYISHNLAKAFESLFGSVTCLPGCFTMYRIRAAESGKPLFVSKEIVEAYSEIRVDTLHMKNLLHLGEDRYLTTLLLKHHQKYKTKYIFNAHAWTIAPDSWSVFMSQRRRWINSTLHNLMELMPMQQLCGFCCFSMRFIVFLDLLSTIVQPVTVGYIAYLIYEVASSSSVIPMMAFVLLGAIYGLQAIIFILRRKWEMIGWMVIYILAIPVFSFALPLYSFWHMDDFSWGNTRIVTGEKGQKIVISDEGKFDPASIPRKKWEEYQAELWEAQTLRGHDDTRSEVSGYSYGTKSYAPAQSEWGGYAAPSRPMSQLDVPVPRNQSRMSMAPSEMLSQRGSTFFGGGGGMGVAELEMSTIELPNDDAILAEIREILRTADLMTVTKKSIKAELERKFGMGLDAKRAYINSATEAILGGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDB5</accession>
    <name>A0A2T6ZDB5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000373">
        <property type="protein sequence ID" value="PUU73485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDB5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDB5"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49122" checksum="642B02129EC9E0BA" modified="2018-07-18" version="1">MGPNLWGAHTAGTATNPNSTSPSPRSEIYQTANAHQTNNTSSIITIGMELEFLIAKTPHSLFFSPKSSIFETIRASLQNFFHAGGISIQTDIFPQRPNHQPDQSKFRLMEERSCDPFLLDHATGKKIPGEAVEICTPIMRFRSWEWVIPTVFEHLTAQFDCRFNTTTGLHVHVGRGCGWDLSAAKSIAKAVIIFESTLDHYHPLHRAPAWNWCIHSNRDNDNLTYFAKSTIMRKLEDAGTFQELINLISPHKFFKYNFNSLKRYGTVEFRQADASIGTDRAVQWINLVVRFVTAAVEATPEEFERWAEDEDPAICCPPEVFDRFGVPWVGAQEQVKDFQMVEDFSFGGGGWGIAAWRGGEAVEEWGLEITQAVQESVDLWTGWEVKEVLLGDNMDLRVLEVRVEEGTNPLEGSLSIEDTRTMIEEASNYLLSRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDM6</accession>
    <name>A0A2T6ZDM6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1003979</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000364">
        <property type="protein sequence ID" value="PUU73592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDM6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDM6"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000011">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="11"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="352"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="739" mass="83956" checksum="217583C2F5DB849D" modified="2018-07-18" version="1">MTLGLQEASILEDLLFVFMGYEGQYIRFRGDYNPASESDRLAGPQFKILPGLDPSLRDLANTMLEMATHYGAVEAFVEVHSREEFGAVNHALCSSIRRLLKEYLVLIAQLEHQFLTSPSFTLHVLHLRTLPTSHMMFQLYTLAREMLRRNSMLEDDLEDSADDLDDMENILESLREGGDVVGGGGVPGSKICKGGSVLGLLTLRLASMAGDPAARSLLSLLLREASRPYMNMLNEWLHHGMIRDPHAEFLIKEQKSIRRERLEEDYTDEYWEKRYTIRDGDVPPQLEGVKEKVLLAGKYLNVVRECGGVDVSKDVGDVPKSFEDIRFLDNVNSAYAHANESLLNLLLTTHALPARLRSLKHYFFLDRSDFFSYFLELGATELQKQAKKVNVGKLQSLLDLALRQPGSIAASDPFKEDVKVQMNEVGLTKWLMRVVSVSGIDEGATTFEESHRAPAISSIEDDKSVIGFNALELDYSVPFPLSLVISRKTVLRYQLLFRYLLSLRHLETLLVQAWQDHNTLYTWKHKSKYPQVELWKRRAWTLRARMLVFVQQLLYFCTSEVVEPNWNGLMKRLGEVRTVDELMQDHVDFLDTCLKECMLTNSKLLKIHAKIMMTCTMFASYTSHLSKALITADPDLASPSAKYMGNEDAAFDQARLDKLSDNLSKYEENFSRHLKILLDALNYYAATETVVLLGLCARLSTATNDADTQGLYIVKKKKSNGILTTPTFPLTPRCANWKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDM7</accession>
    <name>A0A2T6ZDM7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1134871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDM7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDM7"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="303" mass="33584" checksum="B2644596813B11CC" modified="2018-07-18" version="1">MQMDPANNHRSPRKRRRIASPTPSRLSKAEEAEATACVICQEAISEKAVAGPCGHEYDYICILTWAGVKPLCPLCKVAIESLEVGGVKHNVPWKPAPPQPTFHTSSPSTTTSTHRRSYRPRRPRSPLHPSSTLTRRHIYTHALRSSHVGANRLSNHTNFTPAAFLASTHLQSRARAFIRRELSIFTFLADNAEFVLEYAIAILKSVDLKSASGAAEDMLAEFLGRRNAGVFVHEVNAFLRSPYERVEDFDRWAQYPSVEKGASGVLEWEREDGGGDAERKERVKVRGGRLGRGSSGGGMSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDP4</accession>
    <name>A0A2T6ZDP4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDP4"/>
    <dbReference type="OrthoDB" id="4149149at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="382" mass="43014" checksum="EE56FE219154B8F1" modified="2018-07-18" version="1">MPAANMDSHEVTTRLHVDELILDYLLWFCTSSLLKERRLRLDDQVGKREWTDAAKSADMGMRLVNSFTQTFKRLHPNAILPDSIALRQRICRFTTVFLRRLDATSPTFTRPSQSGTRTRAWLSRKRASNVIEDLTSSSPSSNVPIASEFSQTPFAPSNLRRNTEEMHRQMGFSSLPAAQQMYWGNISLREGLKEFMVLSSWTCAFNDEVSTLWVETATNYMVQSVLEAYRCEGAKGIDALNECFSWGPTTSQDGLDDDEVIVNEMFGGDDGSVGVLFEEMKTEALLEVLPPDDTPLETHLDRLAEKHTWAVFEETLVSGYLTAVVSAQPSPILLQVFVFSSFFSRWRVILTIGKQQLESGKLNGFEDRDISTLLANAGALVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE14</accession>
    <name>A0A2T6ZE14_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1134720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE14"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="303" mass="33249" checksum="15FEEF9B197FCBE7" modified="2018-07-18" version="1">MVERSKKPGPIPVSSTEPESPGFVFKSDRVKLSLPTGESAEILLHGATVISWVAGGGENLFLSEKAALDGSKPVRGGIPLVFPVFGKSTEGPTAALPQHGFARICKWELLGRTSETDTSIQVDFGLGPENLTVEQRKQWPYDFGLIYSVNLSKSSLETKMLVRNEGSETFDFNFLFHTYLRIPDVNNLTIEGLKGTSYKCKVTKSEAVEEMVELSVGSEVDRVYANVPDTVQVKNGGEAIFKVDRTNLEDVVVWNPWEGASKMADFGPEDGYKNMICIEAGAVSKWHTLEPQSVWEGSTIINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE71</accession>
    <name>A0A2T6ZE71_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1003121</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE71"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE71"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="259"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="515"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU73782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="600" mass="66398" checksum="2B72F69EECF25EC7" modified="2018-07-18" version="1">MSWKLPKSLKQLKETHLGAPSTSRSSSTSTITPNSNAQASTSTLVASDGTVPTTATSTNSGDAAPTSTVKPGLLIVTLHEAKGLSLPPTHPAYNSQRPSSSSSNGTPASRPGTANSTVHHGHQRAMSKLFRTYCVLEFDKTQVIVNANSGTLDSPMFSGYTTQYKFDVSRDTDLSIGIYMRNPGSVGRDEDLFLGSCKVQPRFEEPTAPQPGKKGQQQQPAAPGFSGVDWVPLSMSTGSVRLGIEYRRNQDMPLTIEDFELLKVVGKGSFGKVMQVKKRDTQRVYALKTIRKAHIISRSEVNHTLAERTVLAQINNPFIVPLKFSFQSPEKLYLVLAFVNGGELFHHLQREGKFEINRSRFYTAELLCALECLHGFNVIYRDLKPENILLDYTGHIALCDFGLCKLNMKEADTTNTFCGTPEYLAPELLLGHGYTKTVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILQDPLQFPADIDRDAKALLIRLLDRDPEKRLGANGAAEIKANKFFETIDWKRLLQKKIQPAFRPNVTNAMDTANFDKEFTSEVPTDSVVDGDFLSQSVQQQFTGWSYNRPGQLGMGEHGSVRDPGPGSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEI2</accession>
    <name>A0A2T6ZEI2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_496561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000335">
        <property type="protein sequence ID" value="PUU73895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEI2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEI2"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="274"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="431" mass="47406" checksum="B5C8758A18B7DA56" modified="2018-07-18" version="1">MVLFWPFSRRDDNSPDSFERILSKLASQIQTQTTKLTGLRQRSRRYKALFTLYTVIGYILYVVVIVLVVGWKEVGPVELSGVTGGPVCIWSIRKLFDLYYNYRIGNAEGVLEELQTKQNDTIEKLKAATKFSTTQSIIEKYGRGSSSGPPSPADTDRKQQQRPGEQGGSINQQLRQRPQGQSGLQGPAQVASPIAPSTTQQIQQQLIQQQMMAQQRAGLPPPAQMQLQPHPGIKPDTPEISSRPSPNASLPNLPQTQPSSQQLIQPEEATTPKWYDRLLDVIVGEDETSAKNRYALICGNCRMVNGLAPPGTTSLEDMEGWGCARCGTWNGSPPGQRRCAKSEGGTRRLTPDILDGGKAKGRRATRSPSPNPENARTTRSKARKEQELHSSSDEEDDTLEREVKPEGGSSDEEILEASQPKTKGGKASQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEU7</accession>
    <name>A0A2T6ZEU7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_490251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000327">
        <property type="protein sequence ID" value="PUU74020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEU7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="134" mass="15392" checksum="030CF60FF0B6177B" modified="2018-07-18" version="1">MGVLGRFLLILFSWFWWVGGSFDILLGGCFAVVFIIIVFILIISPFMNPAKLENGDIRDYSYHFFLFLFCFLFSQTPFVCFQATTLVSSSCPYFFCSTFHPFNSFILIWRGPVKFGRLVGLVLPGLVNSIAIRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEZ7</accession>
    <name>A0A2T6ZEZ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_484593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEZ7"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="124" mass="13600" checksum="13B9F74960DE2904" modified="2018-07-18" version="1">MLTRAILTRQHLRFLASTRTSPRHCAPSLVFWRGILAGRPKSDSKAMRAHAEKVLAYYTGKRTLFLAALKLSTLFLSCFSLVIAAPAVGSQTSWGALGFIGVALVGTIPMAFIQYIRFVPSFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF10</accession>
    <name>A0A2T6ZF10_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1093736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF10"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF10"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="85" mass="10251" checksum="8F60B0842FB0471E" modified="2018-07-18" version="1">MKMEIPSLKLFLQRMRVLSLYRDALRSIRCDILIENPAAKSEMRSWARQEFERNRHVEDLAHIRYLISNGKKDLETMTRYTIQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF25</accession>
    <name>A0A2T6ZF25_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RPEL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1056799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF25"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF25"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14768" checksum="72F407C6B8EBA2E7" modified="2018-07-18" version="1">MADTVPAGELATSPIKERQNSLENALAHRPDRGELEERNILHTRAEISERQQELAKAMAQRPERDDLVQRNILPHNANVAPALVAHQRELEKNMLERDLKEKLSHRPEPQEVIQKGILKPDEDPTNPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFN7</accession>
    <name>A0A2T6ZFN7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_462234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000308">
        <property type="protein sequence ID" value="PUU74282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFN7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="19304" checksum="6C571B21F0451BCF" modified="2018-07-18" version="1">MPIISALPYSSHYLYSTRHRAQDNSPMFPSASLLLLRKCPSPDRNLVHLLVHLWKWSWEFPPTSSLFFGMHGMKLPRIFFKKTKTKRDVDTVASYLNDDWAGHWFNLLNIFAFCPSYRNIHPGIPRYLFSFSLTNITTKVTTWGKRGTYEGDGWVDGGMGEWGNGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFZ0</accession>
    <name>A0A2T6ZFZ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1092965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000302">
        <property type="protein sequence ID" value="PUU74405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFZ0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10889" checksum="3144D6DEE48E4000" modified="2018-07-18" version="1" fragment="single">MLIISNTIRFSSQIRSPKGHAPLQKPNLSENLANSHPSFLPTFRRLFPHLHPHSIVCLTNHRHRHPTANTEPHEKLTMVKKGYHRAIGKARAHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG22</accession>
    <name>A0A2T6ZG22_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1116892</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 11">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000298">
        <property type="protein sequence ID" value="PUU74448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG22"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG22"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000015">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000024">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="13">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="10">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU74448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="426" mass="45041" checksum="9F0F77EE0261F8D3" modified="2018-07-18" version="1">MRRVVVTGVGAVTPLAVGAAKSWQRLVEGQCGIRSIKNRPEFNGIPSQVAATIPFGTSRDGGWDPNEWLRGGDARRMALFAQYAIAAAEEALGDARWRPTSQDERERTGVCLGSGIGSLNDMYDASTTFSEGGVKKLSALFVPRLLINLAAGHITMKHRFQGPNHAVSTACTTGAHSIGDASRFIQFGDADVMIAGGSEACIHPLGLAGFSRLKSLSSDSNSHPERSSRPFDRDRSGFVMGEGAGVLVLEELEHARARGVTPYAELRGYGLSSDAHHITAPPEDGGGAYLAMKRALQHAQIKPRDVGYINAHATSTILGDAAENNAIKWLMLGEDGHKKASDVNVSSSKGAIGHLLGAAGAVEAIFAIKALDEDLLPPTLNLENTTEEFDCNYVPLKAQSRKVGVAISNSFGFGGTNASLCFSKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGE1</accession>
    <name>A0A2T6ZGE1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1133249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGE1"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="28233" checksum="B467161A9C25952D" modified="2018-07-18" version="1">MSLPLPFFKTKFEDKHIVDQKFYMAKHNEENRDIMLFANEVHEKPNNSGPAKTAAMAMPSPVSAPPPREPTVASVENGGQNKKGNKGKVLSKEEEQRLLFESASYRLNGNRLFNTSHYLAALDAYLLALSRCPQTLKLERATIYHNIAATQMKLRSYDEAVKAASKALDLRPGWGKALYRRAKAREGMGGWAGLVGAYDDYVQVLEDAVDGTVEGVGKGELEAVKEKIRWLPDRIKTVREKEVEGVVGAMGGLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGY5</accession>
    <name>A0A2T6ZGY5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="10">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="10">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MEF1</name>
        <name evidence="12" type="ORF">B9Z19DRAFT_998475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGY5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGY5"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="99"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="183"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="769" mass="85093" checksum="8227266CE20571F3" modified="2018-07-18" version="1">MRAVKCQLRTLRPFPSSTAARTLRISATVARKPLKCSGPHSPLSSPLMRTGYPLALNRVSNIRGLASVAAAPAVSEEPDIIPQEEILAKMDPREMARLARVRNIGIAAHIDSGKTTCTERVLFYTGRIGSIHEVRGKDAVGAKMDSMDLEREKGITIQSAATFCDWVKKENGVDEKYHVNLIDTPGHIDFTIEVERALRVLDGAVMILCAVSGVQSQTITVDRQMKRYNVPRISFVNKMDRMGANPWKAIEQINSKLKIPAAAIQVPIGGEDSFQGVVDLVRMKAIFFEGHKGINVVEKELSEIPAEVKKLAEEKREVLIAALADVDDSIAELWLEEKIPTLEQIKAAIRQATLARKFTPVLIGSALGDKGVQPVLDAVCDYLPNPSDGNFGQLTYIRVYQGTLKKGMHVYNAKSGKKIKVPKIVRMHSDEMEEVPSIGAGEICAVFGVDCASGDTFTDGGLPYSMTSMFVPDPVISLSIKPKNKETAAFSKAMNRFQREDPTFRCKVDPESQETIISGMGELHLEIYVERLRREYGVDCVTGKPEVAYRETIDSRQEFDYVFKRQTGGAGDYARVMGYMEPTRDPEGKNHFEEQIVGGHISEKFLYACEKGFLKSTEKGPMIGHRVLGTRMIINDGATHMVDSSEMSFKTATEYAFRDTFKLANPVILEPIMKVAISAPNEFQGNIVGLMNKRNAVIEDSEIGADEFTLTATCSLNAMFGFSSQLRAATQGKGEFSMEFKDYLPTPPQLQKELIANFEKERARRNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHU8</accession>
    <name>A0A2T6ZHU8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1067711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHU8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHU8"/>
    <dbReference type="OrthoDB" id="5590473at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18724">
        <property type="entry name" value="PIN_LabA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF5">
        <property type="entry name" value="NYN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40789" checksum="4411DFE8470395EA" modified="2018-07-18" version="1">MADTSTTTIFNFSTVIALSDALATSQNSNPLVINPDKISGATPHKSLGDFTAIWNFLGLSPEPCTTTDEDDSLPPLKSIQHREESVKSATRVPLGPMQLPNKLHRRVPANANLEDPFDKRPVIRSSMTSIERKAQLIQKILSLFPAQASHLLTRPGLRSGAKDPSDTDIHVFVDASNILIGFYECIKKRRGYSRGAAVRQPAFSFHGLSLILERGRTSSKKVYVGSSPTTVSALDARSLGYEVSLLERVEKERVNAKYSSSSGSEGTQKQRTRKVEQAVDEILHLKILESVLDFTPTTIVLASGDAAQGEYSPGFFKVVERCLDRGWKIELVSFKASLSWLYSNKDFLKKWKGAFSLVLLDTFVEELLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHV6</accession>
    <name>A0A2T6ZHV6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1195757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHV6"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="15561" checksum="60CFF203BA06A030" modified="2018-07-18" version="1">MKSPISLNQKYQNLRLTLRLALRVLPSSPPPRILAITPSYIKLAVEPPPKSGAANEAVVRFICELLGYPKTDGRIVMGRKTQGKVLEIRGVGTDEGLVERVREKLMPPPAVLPVVPSVPGGVRTTKDESVSSSDGLDGATAVGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIP1</accession>
    <name>A0A2T6ZIP1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rpp14/Pop5 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_995012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIP1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIP1"/>
    <dbReference type="OrthoDB" id="24745at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3250">
        <property type="entry name" value="Ribonuclease P, Pop5 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002759">
        <property type="entry name" value="Pop5/Rpp14/Rnp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038085">
        <property type="entry name" value="Rnp2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15441:SF2">
        <property type="entry name" value="RIBONUCLEASE P_MRP PROTEIN SUBUNIT POP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01900">
        <property type="entry name" value="RNase_P_Rpp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160350">
        <property type="entry name" value="Rnp2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="169" mass="18179" checksum="DAB02F567824FA6A" modified="2018-07-18" version="1">MVRYKARYLLITIYYPTEPTPSSSNPTLPFTHPSHPSLTKQSLSNLIRDSLALQFGDYGAGAAGNMAVKYFSPATSTGIIKVSRAHYRMLWASLTFIKEVLGRGAVVTVVRVSGTIKKVQIEATRRAKEGIRRAQGVGGEGVGLDVMDVMGDDDDDEGGEGEESEGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIQ8</accession>
    <name>A0A2T6ZIQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1131497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIQ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIQ8"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="268"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="440" mass="50761" checksum="941D632CB8466693" modified="2018-07-18" version="1">MTLTPSHRSSLAFGLRWESKLFGPVPAWAATPNIATIEALSRQHLGADNLSVEFLAGGAFNKVYLITVPSNNILGPKFYVFRVTLPVEPFYKTASEVATLRLLRQCTSLPVPEVFAYDCTTENELGFEWIIMEKIPGVPLEELWPLMSLEDKKIVVERLGQFSKELREKCKFNAIGSLYQRTELSEGDLKVTVATDYNDFVIGPIVNSFFFIGKRKLLIKRDRGPYRNDQAYLLALMKVEQEDKKLLLKLTSDKRAASIQKAKDEYSESDEDEDDDDELAEDVPEIQETIQQLREILPSIFKDMQTEEFVLRHHDLNRSNVMVDYMTLEITGIIDWECITTVPAWEDTYPKMLRGEDMEEEPEPLAFGDTDVSRVERWEKWENTKLRKIFDQAAGSGANNDKDACDKRGFRQRLNWLEISTKIVKDWIIEYEERKREQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ00</accession>
    <name>A0A2T6ZJ00_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MBOAT, membrane-bound O-acyltransferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1067413</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000230">
        <property type="protein sequence ID" value="PUU75461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ00"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ00"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF23">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="568" mass="64463" checksum="576D1CD38B70DD45" modified="2018-07-18" version="1">MSQRAPSTGNNGAPSATSSHTFLLGELQTTTSSDPPSPESASPTSEFDDARLPANSAEKPVAGLGVGGEHEGKGFQQEVKRRASIPVRLEKIRGKEKYRLVIDDELRKLLVGASVAGGKRKKKFSDPAPSPGRHSTKKLTSNRMSVVMLVLKLAATSYREHGRLFGIDILSIMFNPNNLIDCLLVDATMFWGSALWCVPLQKAIAKGGISWERTGWILQMVWEAVYLGIVIEYTLWKDWPWIQTVFIVLHCLVMLMKQHSYTFYNGHLSVVYKRLQSLEKKLAELRALDTSGPNVRHHVRAGSVDSGVDIREGLEEKEELDSAQVEGFERAIMEELAACNAELSSHVEDDDGPKVVYPQNLTWWNYFEYIHFPTNRVVYELAYPRTTTINWAYVLEKTTATFGVLGIMIVVSQHLILPVVLQTHALRLLPLSERLQAFPYILLDLIFPFMIEYLMAWYLIWELILNVLAELTFFADRGFYGPWWNSTTWDAFARDWNKPVHNFLLRHVYHSSISAWHVSRGTATVITFLLSAIVHELVMWSLFKRLRGYLLIAQMSQIPLVLIGWIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJA0</accession>
    <name>A0A2T6ZJA0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rad1/Rec1/Rad17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_890985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJA0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJA0"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01245">
        <property type="entry name" value="RAD1REC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="344" mass="36711" checksum="09EC174BC58691C7" modified="2018-07-18" version="1" fragment="single">MSQTQENPAPPPLFTALTTSSRQILTLLKCIGFQSKAQLQISADGLRVTVEDSHVMQGHAFIDKNLFTTYTFHPPPHLTENLEEDEDPVIQFGISLTALLECLQIFGGGDAGGGGGGKWRGSGGRAGGGGEGWSGGTAGVSAFDHSLLRIAGTCRFLYEEGGPLCLILEESPITTTCELTTYTPAPLPDIPLSPTLTRKIILKSSLLYDAITELSSSSTHPSSSSFLVVSTSPTPPHFTLSSTSPLGTTTVEFSNDGELLETFMVSRRAKDVYRFDLVRHARGAMAVATKVSVRSDQGGVLSLQFMVEWEGRASFVDFRFLGVDDREGGGGGWGENAEEEGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJH1</accession>
    <name>A0A2T6ZJH1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 16">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B9Z19DRAFT_1130988</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000221">
        <property type="protein sequence ID" value="PUU75632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJH1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJH1"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000030">
        <property type="entry name" value="Branchpoint-bridging protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000024">
        <property type="entry name" value="Branchpoint-bridging protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="407"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="568"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PUU75632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="622" mass="65394" checksum="3C285263EF003150" modified="2018-07-18" version="1">MSYRGSGGGITGTNNVPLGNRRRFGGEGSTGSNDSPSPASGGPSSREEQGGNGLADLKRGRSPVRSHPDGPKKRKKKNRWGDQTDNKAAGLMGLPTAIFATMTSEQLEAYALHLRIEEISQKLRINDVVPADGDRSPSPPPQYDNFGRRVNTREYRYRKRLEDERHKLIDKAMKAIPNYHPPSDYRRPTKTQEKIYVPVNDYPEINFIGLLIGPRGNTLKKMETESGAKIAIRGKGSVKEGKGRSDAAHTSNQEEDLHCLIMADTEEKVNKAKKLINTIIETAASIPEGQNELKRNQLRELAALNGTLRDDENQACQNCGQIGHRKYDCPEQRNFTANIICRVCGNAGHMARDCPDRQRGQDWRNNDRGGRGGAAGGFGRPGAAGLGQGDAVDREYEQLMQELSGGAAPAIGGSAPQGRIEAGPGGPDGGYGGRDSYGGGAYGRDNQNDQDLGPDGRALKPWQRGPTGGPAPWQMGGRGRGGAPGDSHTPPTNAPTGPSGAPWQSQSHGPPTGPASSAPPPWAGSHGIPPPPPPASAAPPWASGAPGAAPGMSYGASPYGAPPGGYGAPPPPPPSFGIPPPPPPPGNPPPPPPSSLAPPPPPPPPPPSSNEPPPPPPPSHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJS2</accession>
    <name>A0A2T6ZJS2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B9Z19DRAFT_1089697</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJS2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJS2"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012744">
        <property type="entry name" value="Nitri_red_NirB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02374">
        <property type="entry name" value="nitri_red_nirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011565">
        <property type="entry name" value="PRK14989.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015595267" description="Nitrite reductase [NAD(P)H]" evidence="22">
        <location>
            <begin position="23"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="958"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1098"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1133"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PUU75732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126504" checksum="6DDC780DEA267F41" modified="2018-07-18" version="1">MDYFLDLLCLATLAFLRYKSSSTNMSVAIEVPLSIKSEDTILVPAEMDSRPSIANEDGPIVPNGNGTDPPMPQRKRIVVVGLGMVAIAFIEKILKLDAENKQYEIVVIGEESHVAYNRVGLTSFFEHRKVEDLYLNPKEWYESKPDVLNHKINTKVTSIDPVSKSVTTSGGYDVSYDVLVLATGSDAVVPSNTPGHDSKGVFVYRNIEDLEKLISFSATVKGSTGCVVGGGLLGLEAAKAMMDLEQFGSVKLIDKNPWVLSRQLDQDAGKLVLEKITELGLDALSCRKIKTINSNENNQTKSVTFEDGETMDTTCICFAIGIKPRDELADSAGIKTASRGGFIINKDVETTVPGIYAIGECASWENQTFGLIAPGVEMAEVLAFNLCKSALHGHSETPKAFRRPDLSTKLKLLGVNVASFGDFFADRDGPRELPGRSPSQERRGREVKALSYRDPFQAVYKKYIFTSDGKYLLGGMIIGDTADYIKLVGMVKSKKALEIPPSQLILGAKTEGEENPDDLDDDTQICSCHNVTKGDISKVVKDGSCKSLGDVKSCTKAGTGCAGCIPLVQSIFNAEMKAMGAEVSNHLCPHFAYSRVDLFNIIKVKEIKTFPEVMRECGKDPESLGCEVCKPTMASIFASLFNQHVMDKPMHMLQETNDKFLANIQRNGTFSVVPRVAGGEITPEKLIAIGTVAKKYNLYCKITGGQRIDMFGARKQDLVAIWTELVEAGMESGHAYAKSLRTIKSCVGTTWCRFGVGDSVGMAIRLEERYKSIRAPHKIKSGVSGCIRECAEAQNKDFGLIATETGYNIFVGGNGGSKPRHSELLIKDCPVERVIPVLDRYLMFYIRTADRLQRTARWMENLPGGIKYLKEVILDDKLGICDQLEKEMQDLVKTYFCEWTEVVKDEERRKQFQQFANTSEASETIEIINERSQSRPTYWPKASVKYDFKNHRWSNLAWQPIIEASYFDNANSSTPVSAAVKRGDTQLAIFKVRGKYYATQQMCPHKRAFVLSDGLIGEDPDDGTEEGKKKKNMWVSCPYHKRNYTLEGKTPGGCANDEEVSIATFDVEERSDGWVYLKLPSVAELDSLLGTERWKVKKEESEDPFKEMDKKISNKGRKAAKPTEVLNGNGSPTEKKINGLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJY6</accession>
    <name>A0A2T6ZJY6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1116249</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZJY6"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="15">
        <location>
            <begin position="262"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU75766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1456" mass="164184" checksum="20CF6492262887E1" modified="2018-07-18" version="1">MLSTATREGMKEQVVDNLPKRIKEVKFGIMSPQDVVKQGVIEVAKRELFDLEGGGRKPKQNGALDPRMGTSSKSGVCETCGEGLTNCNGHFGHVKLALPAFHIGYFKATITILQNICKECSRILLDDNQARFFLERLRTPGIDNLRRMNICKKINEQCKKTKICYHCGALNGVVKKAGPLKIVHDKFRAFNMSTAAKKVPPESKMAFEQSFEEAKKTNHDLDKHLKKAMDDLNPLKVLNMFKQILPIDCELLGMNPQEGRPEMFLWQYIPAPPICIRPSVQQDSASNEDDLTVKLTEIIFVNSLIRTALQSGEAIHILMERWDYMQAQIAMYIDSSLPSLQRNYSDLKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDQVAVPMLVAKNLTYPERVSRYNIHKLQQLVQNGPDEWPGANYIIKKDSDFKLWLKFGDRRRAADALVEGDIVERHLEDGDVVLFNRQPSLHKLSILSHYAKIRPWRTFRLNECVCNPYNADFDGDEMNLHVPQTEEARTEAIELMGVKNNLCTPRNGEPIIAAIQDFITASYLLSSKDRFYNRKTFANICMFMVDGNMQIDLPPPAILKPQRLWTGKQVFNVLMRPNKKSEVLVNLDAKCRDFKAVPGKAPDMCPNDGWLVIRGSEIMCGLMDKSTVGSGKKDSVFYVILRDYGPDETVQAMNRLAKLCARWLANQGFSIGINDVLPGTNLRREKDKLVEQAYDECDTLILDFKEGKLEKQAGCDEEVTLENKVQGILSNVRDKVGDICMRELSKNNSPLIMANSGSKGSKINVSQMVACVGQQVISGKRVPDGFQDRSLPHFPKNSKQPPSKGFVRNSFYSGLTPTEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSASYDYTVRTSSSGVVQFQYGGDNLDPVAMEGNARPVNFNRTFYHCENITFSNADKGLLPYEIVSLCDEVLGPYQQKLPRIDLLENEIPDKDLTDRTLDEHESKRRFYNSIRDYMVEKACKLGALRLRYNLPPHEEPPDADYMDVDDSYFSAHDVNAVNRIMKISEKHLREFLRQCLSKYEKAKVEPGSAVGAVGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPIITCTLVTEDDERAARIVKGRIEKTYLEDIISYIEDVCSRDDNYVSIRLDQETISKLQLELTIDDIVTALVKAKLKITRQDIRVIGNRIRIYVHEMAEKDRKRTKDESDVFLRVQNLKRALPRVAVKGYPNAARAVVKKDDKTGKNQILVEGYGLKLCMNTDGVVGTKTKSNSIMEMKEVLGIEAARGSIIDEISYTMREHGMDIDPRHMQLLGDVMTYKGEVLGITRFGLAKMRDSVLQLASFEKTTDHLFEAAFHMKSDAVEGVSECIILGQSMSIGTGAFKVVRRLMIDPRDLFPKKLVFEEAYANKYRPQENPGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK17</accession>
    <name>A0A2T6ZK17_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7357 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1130686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK17"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK17"/>
    <dbReference type="OrthoDB" id="5368821at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024822">
        <property type="entry name" value="Coilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15197:SF0">
        <property type="entry name" value="COILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15197">
        <property type="entry name" value="COILIN P80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7357" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="937"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1196" mass="131197" checksum="6DD13111A6907A83" modified="2018-07-18" version="1">MRLRLFIQRNRLPATKIWWDTSSFEPGDDHNVSTLLSRVGQIVPMESGGWGLEDYAVEVDGFEVLHFQEVERIIREGDEVVIRPLTTTEIRQRRASGRRQISTSGRKLMDGTPFGRPMITTRPAPDRPRLSIPPKKRVKTGCDADHSTLVQVGSDGGDESDESYKESDEEQEVSEVGDDDEVVRADMGAEVETYAESDEAEESDEEEEDGIDEADFEELSRDYENPLMDYFDSDEVATSQVASSEQPSRLKAICGARDTQSLQGQNGSLQRDSSEDDDDYADSESSQDNDSSDGSDDSGDAASSDEESMEADIVRQVGDFFLPDYFYSDASAAGGAVDSPKLPQIYQSGGTSGEVGGDERESESESLSLSESSVSTGPEQDEDSRSSSEYPSDSSDSEESSESEKAVVPKDERSSKKASQNRVPGTSQGPPSPRVSLVPIEQPKKLAVAPGTLPHQKNRRTKARNERKKQRRKTEGLLAELVNTGVLPKGSTIDDLKNYQDKHNLKNAGEQLRHKRQRPCVGGGEKQTNLELSEERIVEEPPRDVADHVLQKAQQEQQSNDLAGGGANKKNQRKKLRKAFTKAKKKKSIPENWDFSRWLTEREKKVGAEGQPDNIDVEGDADGDVSMESVDRPVELSSKISSEQTGISLSHDQPPPLPPHRGPLVPAREGSRPRGPRKIVYDEDGVPNPVYAGFDEQQHEVDDPEAWRGKIVLSAVECEQERVEIPAPEFPFKQPAYQPGFGWEATGNNKRKRHGGTKRKKKQRQQDKENYSYDYGHQNYQDPGYGDWEGHDYYDDSTVAPTSTKDKATDMAEADPVDDLPLLPDNIASLYPLTKPVLPGTIVAFKQLMLTEDYTPIMADYRTAIVQAVHAQEKDGPALELRLAVRDRPKRRIDPETGEKILRKFEMPGDEDEDEGLLDLMFGQLLEAKVVKLPEGLDQGVNADEGAGDGEGGDTQEGNPDNQKNEGNANQSAPEGGDSYSPDIQVNATLSDGLVPPSAGASQDQEQDLELSLRPETQAAQPQESLKSPSPVSGVLGTAISLSSAPTSQVEASIPPVSDKGESDLSYEPDSVSDSDGLETLESMFASSQRIKPEPSSQRSPVLPPLPVFSPLGAGVEEDEQSQRQIQEEATNEKRAALKAARRTKPPNGAKITNSEVQIIDLTGTSDPIIMDDSPRGKKGSGRSRAKGKQWRAVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK81</accession>
    <name>A0A2T6ZK81_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Swiss Army Knife protein DSP-PTPase phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1130590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK81"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife protein DSP-PTPase phosphatase" evidence="3">
        <location>
            <begin position="145"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="325" mass="36756" checksum="0AD3CA8C44432ECB" modified="2018-07-18" version="1">MFPPGRGNDHLNAGDIYWISLLGTNKVMTAKGEKLYLREYQKGRWDQMWICETNLDGRISMRNRHTQRFLGRRVDHTVGCVSSHSGDSEWLTITRLSLGGYSLEVSREGNKLRPIQCVNGDGPLLKIGGVSTQFGLHKIKNPVFRRFEWVIPGHLARSSAPYYDIEDADQSMNETSIEFLDHYQIRNIISLNSVELSPRERARLRDAEIAYSHIKAMEYAAVTQEQFDQIWDAYHKSGPTIVYCGYGDGRTGMAISAIQLFQGQALDDRDYRENGVQCPTQLAALNALSDRINSVESDSDPVNTLDTQLPPCTVPENTTPEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKA6</accession>
    <name>A0A2T6ZKA6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial-processing peptidase subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alpha-MPP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Matrix processing peptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1029918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKA6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKA6"/>
    <dbReference type="OrthoDB" id="277191at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000023">
        <property type="entry name" value="Mitochondrial processing peptidase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000032">
        <property type="entry name" value="Mitochondrial processing peptidase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="55"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="12">
        <location>
            <begin position="207"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU75927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="549" mass="59526" checksum="C3CC939CBB16AF39" modified="2018-07-18" version="1">MIRSSLKKISSPLSILKPRYPFRNTHRAFASSVLNIPTKDPAELDNITTLPNGIRVATEALPGHFSGLGVYVDAGSRYENSRIRGVSHLIDRLAFKSTSTRSSDKMLETLESFGGNVQCASSRESLMYQAAVFNKDVPSMMGILAETIRDPLITEEEVVQQLDTAAYEIQEIWAKPELILPELLHMTAYRDNTLGNPLLCPEDRLDKIQRETILEYRSTFYRPERIVVALAGVDHSTAVKLAERYFGDMKSAEPSPSSLHAGASSSSSGSYASTLSPGILPKVPLAKNLSTSASRSADAHSSCPNINLSIPSHYTGGAITLPPSDLPSHLPSFTQLQIAFEGLPISDPDIYALATLQTLLGGGGSFSAGGPGKGMYSRLFTNVLNQHGWIESCVAFNHSYTDSGLFGISASCHPGAGPHLVDVVLKEFTATLANSSYSGLQNAEVDRAKKQLQSSLLMNLESRMVELEDLGRQVQVHGKKLSPLQMCHEIEKLEVKDVRRVAERVLLGQVENAGKGMGRATVVVQGGEMEVVAMGDLLQVVRDYKLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKL5</accession>
    <name>A0A2T6ZKL5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1130454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU76022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKL5"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015650580" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="122"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="589" mass="63872" checksum="FD755588977B2591" modified="2018-07-18" version="1">MRIYGILLGTIVPAVYATYGDSNVGAEVCKCSPSDDCFPTLADWQTFNSTLGGQLIKIIPLASPCFSPSNSSNSETCEYIRTHWTNSTLHASDPASIMMPMWAGTGESTQGPCTPTSAHCDIGNYPVYSVNVTSPQHVVDAICFARKQKLRLVIKNTGHDFLGKNIGFGALGVWTHNLRGVEFHDDFLDGEGSAVTLMAGMQWGEVYDEVAKKGFVVVGGANPTVGSVGGYLQGGGHGYLSSRHGLAADNALQFTAVTADGSLVTANKHSNPDLFFALRGGGGGTFAIVLSATLKTYPTPQTTRHAVLMVSPASSKSHEAFWDAVAYIHGHLPRLADEGMAGYFVVVPQNGSMVFSWSLFIYERPPNTATTLFSPIESHIKDTYPGLHLSTTEQQYTTWLEAYKPNIYPESVGHNSLLASRLLPRAALENNFENIRSTLVTAFPKVSDGGIVGQLIAAGQVSRNRHLHTAVHPAWRSAYLHLIIGVTWPDNIPLSSALEIRRFNSEVSVRALDKLAFAAGGEDGVGAYLNEADGYTRREDAGRVFWGSKYAELKILKERWDPEGVFWCRLCVGNEEWVVEEESGKLCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL57</accession>
    <name>A0A2T6ZL57_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1088830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL57"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="16104" checksum="20C143AD3CDE4D67" modified="2018-07-18" version="1">MVACYRFQGSWKWEKGLEGIMESLPTKPTLSGRCYLHRCIYHPLCTTILAQYTLLLPKNRTHPSNPRPPNRRDLDSTRWAVTFPSSPSSNANRAQPPRPFQETISVNRRRTISTIDPINQTNPTCHQNTKHEHNLSPLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLB0</accession>
    <name>A0A2T6ZLB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_260224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLB0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="13649" checksum="1AE3A72B74CCB249" modified="2018-07-18" version="1">MFLVLPSLRKYHPIAAVFLFLSSDGLDTAPRPTTSRSGYLYLCFRSIKDFFVSFRSTLSTQQGLLLVHGIDVVESCTQVSCTRRSHKAASPHERAQERQSKRLKFFDTGVPEKITGRPTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLK5</accession>
    <name>A0A2T6ZLK5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_258555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLK5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="221" mass="25195" checksum="111D536CF00EACB2" modified="2018-07-18" version="1">MLLPRYLYSSTQTHTHPVPPPLLPFTRRCPCPAYYSSTLLQHILSRRRGKVRVRLPTGPSLRVNHSKNLLYRRIRTYVYVHLKKNLHPHTLYHTLSSSLLALTIYSPHLFSSAPPLTFLPHTSKKRKEKPFSHCPPLTSLNPFPFLTPSELPPSTQPPSNANTTPNQHPFPFPYNDLHPPSGFIVPLLSPYILIAQKRSKPYLARPFPLPSPLPYPDTGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLR8</accession>
    <name>A0A2T6ZLR8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1088282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLR8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLR8"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="31769" checksum="6BAD29FCA79728C8" modified="2018-07-18" version="1">MSTTTAISPTPKTWLITGCSSGFGSALALAALTSGDKVICTARNTQALSHLTTLGAIPLSLDLTSPPTIIQATITSAITDHGPIDYLVNNAGVVTIGTVESYTINELQEHFTINVFSHITIAQAILPHMRSRRSGVIANIGSIAGWGGGPSLGAYCASKHALAAFSLSLQQEVASFGITVTCVELGYFRTGILEDGKAFEAKKTIPEYEDLMRVARGALKGISMKQPGDPKKGAELVFEMLSGRGRGVGRVLPGRWVVGRDAVSFVKAALKRGEDMVEGWREVVSNTDCDDVDPSKDMIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLY2</accession>
    <name>A0A2T6ZLY2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000186">
        <property type="protein sequence ID" value="PUU76500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLY2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="191" mass="20460" checksum="F5D06066543251DF" modified="2018-07-18" version="1">MHMLVPDNDGYAHQFQLAFMKSLLPLSVRQEALANKGGSPLAKEENSTALLINIPYLTISPEPLTDTPLNTAHQPNNPTTQQLRTSATRHNFITMCRSYPQSSRRQTKAENTSASSPSSSSPSTIFSSATSTTAQTSRSSPTTSGTLGNSTPQQSSGSISPTGSNFSKGSKSFDYSIKHSYGKGYAYSSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM00</accession>
    <name>A0A2T6ZM00_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_248812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000186">
        <property type="protein sequence ID" value="PUU76511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM00"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM00"/>
    <dbReference type="OrthoDB" id="5311681at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="558" mass="61969" checksum="07695D980AE88E40" modified="2018-07-18" version="1">MLYDFLDPRRPATGPDPSRSQLPLDIMSTIISYVESASDLSRVSRVSRILHFLSVPRLYRTVVIRALRTRADDGDKGRGRKQSISASALGALMKPGIASCVQTLRIEGEILGGDEWWAGGMWSDMEVVWAMALAGVMGNMTRLERVEWISESYPHPVLYGAMAKHPTIKSVYVTHPPAEPASLGEKPPLRPPLEIVPGFTNIRSLHFTNIPTSSAYIDDYTRAIFSSPRLEVLYLGFSSRTSVGLRLFFLHQKIHPAGNIGTKLKLKELALRNVSFDFPGGGVVDDWLDTEALEVLSLLDCKIVATGCWPGLFGNHNSSPAAVSSPVSVRSAGSPAGKSSRTSTPRTSALSAPPPEKKHRLKLRSLRINSQAELWAGFLSSYEELEELYILDPPEGEEEFEVAAPAGAFIDTLVTNHKSIKRLRLCSHWVLHKTEVQRLFRACTQLQELGLSFEQTQWPFMEVLVLFLPNIKVIHLLESQLAGKAELEAELISKREVIESSLAVPGLLGFGKFGSGQVFIRMDKTSLRVDGREIKNWQMVDFEEVRDSVGIWRAERSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMI6</accession>
    <name>A0A2T6ZMI6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1087735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMI6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMI6"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="189"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="417" mass="46046" checksum="75BB86E131CFFC1F" modified="2018-07-18" version="1">METPINTLMVEGSIDDQVLEMAQYLETRKGSQGLVAQIKSQFEGEAYDLDSCLREIVNASSALSTAPEREFIPAYNLLIHLVRSSTGLPELLPTILQNLSAPPSTSPINGPALSVHALSTIFNVLPANSPLRYPVFKATLRVVAEHGMYDVLAPQLKNIERWVEEWGSSIAEIRDLYLTIADVAEKAGDADQFYSFLFRTLQSYTPEESTGEEARTIAVRLLKASINLPSCLEFDDIIALDAIQQLSNTDPEAFALLEVFAGGDLEDYEEFNDEHDGWVDDNGIDHSIAFRKIRLLTLASLASSASSRELPYSVIARRLHIPSEEVELWVIDVIRAGLVEGKLSQLNQTFLIHRSTYRSFGKSEWEEVGVRLDNWKASLRNILEVVRGAREQVVAQGGDSVVQTAINGGGNALQVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZML2</accession>
    <name>A0A2T6ZML2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZML2"/>
    <dbReference type="OrthoDB" id="5405453at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="314" mass="34560" checksum="B8759C008236DBBF" modified="2018-07-18" version="1">MPWHQEIVPSAKTSPRSQVEVSRIHSIQASHIQQHCPYFLYLYNSEKIFSTVRAIVKKGKEITPRCRAAIVTLRCLDIPMTFKKIEDITGVLTSTTASDIWRHALANARSACLAVTTTTALPTALPPTASLASLSGGHSATTLPAAALPGSVLSVLPPIGAPALASIPSSASSLISDKEFSLLELISASVLDSDSCSGRPHILSEGNKDRLVKLMKKDFVTWRMTLCDIRREASLSHERQSAEEIVTAASKIQSYNENCAEEESRLNTAWRASEEWEELQRRELLNAREARLLASLTGVKTKTTQSWRDFTNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMV7</accession>
    <name>A0A2T6ZMV7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1066317</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMV7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMV7"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU76828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="408" mass="45611" checksum="B4AD4B79626F3543" modified="2018-07-18" version="1">MYIRQSKLPNLRKYQYSAVDHSLVSRYILKPFYTNYFIHVFPLSMAPNLITLSGFAFVIFNLLTLLWYNPTLDQDCPGWVYASWSVGLFLYQTFDACDGTQARRTRQSGPLGELFDHGVDAMNTILEVVIFAGAMNLGHSWATVLTLFASLCAFYLTTWEEYHTGTLYLGVVSGPVEGVLTLCAVYAITAFKGGSFWQKPMLETLGLPCPDFLPPVLRDMPFAQWYLVYGGIILAFNIVQSSRNVIRARRDKGLPIAPALLGLAPFFTTWLAIPLWLSLRLEILHEHILPFIFFIGASFAYQVGLIITAHLTKSPFPYFNVLLLPILAGTLDALGPFLQAKLNLGWPSVLDGGPYTVAYVLACLGLSIGVYGSFVVDVITNICDYLDIWCLSIKHPYDPNAPEEKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNR3</accession>
    <name>A0A2T6ZNR3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_943422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNR3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNR3"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="12345" checksum="49F82C6E96EC6C7E" modified="2018-07-18" version="1" fragment="single">VPVNTKDFLGRSLVYLAVKMDRLDVLEALLKRKDVDVNSQENRRGKSPFHVAVRRVHLSAVRLLMDDGRVNINLADHYEETPLHSAARWGRMEVVKMLLKDEKLQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNU2</accession>
    <name>A0A2T6ZNU2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1086702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNU2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNU2"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="360" mass="40611" checksum="AFE49B1EECC440FF" modified="2018-07-18" version="1">MPGPTPIPFEIHIPDSLLGFIHDRVRTARLPPPIAHPDGMAATYGVTHETMTALQDHWNNRYNWRAVEDRLNKSLKQFTVPILHAGEDLSIHFVHHRSPRPDAIPLIFVHGWPGSFLEVEKIVTPLTHPPSEKAQAFHVVAPSLPGIGFSSAPKAKNFGPEKIAGVFHKLMMILGYDHYVAQGGDWGSMICRYLAADNPKACIGVHLNFIVALPPSALKNPLELFYLATRWMTPYQKKMIERMVWWRKEENGYAEMMSTKPMTIAFALVDSPLGFAAWIRDKIEPLVDDYEWTEDEIITLCMMYILPGNSAFANLYKEGIIDLKANILRRVIPSEVYFGASSFPKGSHFPSSPISFFVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPF8</accession>
    <name>A0A2T6ZPF8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1086478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPF8"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="574" mass="62618" checksum="1D10FFF802D2C5F7" modified="2018-07-18" version="1">MSSFFSTPGSLKKRKRSEAAAFSSGGKPKRPRESYKDKNAPEDDNISSGSESGNEGGNGKALSEDEEDEDEEFSGETAAEKRLRLAQQYLNNLRVEADEVGFDAADIDRDIIAERLRESVAEEKGKIYRHVSSQLSFATADSTLFRMDSGPTTGIATCSPFIYTVTKDGYLIKWELPAYPRPLSTGTNHTVSKKPKRVMYVRACRKGGADSFQGHTGPILCVAASQDGKFVATGGQDTRIVVWDAGLLKALKVFKFHRGAVTGLTFRRGINQLYSCSTDRSVKLWSLDELAYVETLFGHQDEVVGITALAGERCVTVGARDRTARLWKIVEETQLVFRGGGGSGGAESRKPRKNKDGTKRYEEGTIDCVAMIDEEHFVTGSDNGDISLWSILKKKPVHTIQLAHGLQQTLPPVEHTAESNPTDPPPEPCPYYITALAAVPYSDLILSGSWDSQIRAWKVSSDKRKLEPHGTLGPPGKDSVRGVVNGISIVERGEKGQEVLAVCVGTGKELRLGKWLKVDGRNGGYVIEVGRKEIEKPALTERSEGGQPVGEEVEKQVSIDPAKVDQPSEGERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ05</accession>
    <name>A0A2T6ZQ05_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_165690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ05"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="12827" checksum="07717264E1CB6B42" modified="2018-07-18" version="1">MVFLCFFFYPHRLTYQPTLVGQTAAVTALDHKVFPWGVLGTGGGRSGFWLGKFESFFILNVQIFPFSFFVWDVFRFFILLYTPIYSVFGGVFLNPFFFLVMLIPYPCGCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQC5</accession>
    <name>A0A2T6ZQC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1085724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000145">
        <property type="protein sequence ID" value="PUU77666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQC5"/>
    <dbReference type="OrthoDB" id="5279243at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="59" mass="6816" checksum="FA96E554A75C99B1" modified="2018-07-18" version="1">MSYLFVRNFSHRASGIYRSPRTIMMYSYLVAGFSLPFALPVAKKLSAQNNKSVPHNRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQH7</accession>
    <name>A0A2T6ZQH7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQH7"/>
    <dbReference type="OrthoDB" id="5357079at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015556136" evidence="1">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="21039" checksum="E8EF24E46A1C5EFE" modified="2018-07-18" version="1">MHPHTLLIIFLHFLGVLGHALALLPSQMTHDPAIDHLFSRIYSIAGQVAPTDPATLNQTRTKILSLLSTFPFQQEITATAHSRQLYCETSWASPEYADVASAMSQLYRRAGQECNSNFGCEAMQGWGSAEIGICGPFGYSWDCKDVGGMAFSIAASCWRDLGIMRVGGRYLFDRWWTWSPADVRVYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQY1</accession>
    <name>A0A2T6ZQY1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Hydroxyethylthiazole kinase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1101658</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQY1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQY1"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="16">
        <location>
            <begin position="10"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU77834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="546" mass="58222" checksum="30974F6835236907" modified="2018-07-18" version="1">MPPPRPNLELYLVTDSLNLPPNSTVYSQVEACLSAKHPPTIVQLREKHLSTAKFIELARDIHALTSKHGVPLLINDRVDVALAVGCEGVHLGWDDMDVPTARKLLGPEKIIGLSISDHEQLEKALGMDPTYLGIGPVFSTPTKPDHSPPLGTSGVRSLLSAIPLTMQAVAIGGINHCNVQRVLFQSKDIAGRRLDGVAVISAIMASPLPVGACNLLYETMNWPPLFVPTGYSVRTEDFSIYRDNIHKHKPLVHHITNNVVKSISANISLALGASPIMSENPAEFADLAALPNVGCVLNMGTFGGGRESQDLFLGALREHNVRGNPVIFDPVGAGATNARREFAQMIVGAGYCTVIKGNEGEIRSLAGLGAVKMRGVDGGREEGSGEELAKIVHDLARLEYNIVLMTGPKDYISNGARTFCLSNGSKYQSRVTGIGCALGSVIAAFCAAAPVDESLIGPVISAIGMYNIAAERAESLMDGSDQPGKWAVAFVDCLAAMAMSDENLTELIAVQEVKELTNLEKWETPTGGEGLKQGEDLKQDEDLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRM7</accession>
    <name>A0A2T6ZRM7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1101487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRM7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRM7"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="10">
        <location>
            <begin position="579"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="637"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="673"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="709"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="745"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="781"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="817"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="856"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="421"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="924"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU78141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="985" mass="107893" checksum="DA745897123FB58C" modified="2018-07-18" version="1">MSDHQTAATSRVALSTSVKPARFDDFGSSPNTLDGGASQPTTQGLGNSGAWGIWGNSTIGSTTIGSGFGGPNTNAERRGSSSLLAGSGEHDTWNTKPPAVRWSGESASPALPNVPINQDLSRSPVRLRQYESPQSNSEIPRSSSPFYTMPRQSAVGRGPSLSQSPNNSKPFLDPASAAGFESMDFPNGPRGRPVEIGQGFGSPRFPGTSTSTDTSDRRHLVLPAIDDEDPASQMARGRVVSNPRGPGAEAFGSSVSSAGRSESLPPQQRANSTPPTYNPNQSPPDAVGGYGAYTHVPTSHPASHTPNAGSYPVAPGRFADLSRDTREAEMLAHLRQISVDDDHDRFSASREGVSYSRLSQALTGHPANFNYQNQPPFGEYPYQARQTVQAVAQNSMWTPDDGNYPRGQEAYNNTEQYADANYGEGYGDIRRPYERVGSMSPGDQNGEYQRRNMGSAYHANGSTPPPHGSDFRSSSRGPPIRTPPSGQLTQLTPNHEKLRQRLLVAPQQQQSPHINQGQLIMRDQLYRNQYPPQPPYDYAYGNGIRMPMASYAGSSISPMIAPTHPAVRRPAHEDFGHNLRSVLLEEFRANSKSNKRYELKDIYSHVVEFSGDQHGSRFIQQKLETANSDEKETIFAEIKPNSLQLMTDVFGNYVIQKFFEHGNQLQKSILAKQMEGHVLTLSTQMYGCRVVQKALEHILTEQQASLVKELDGHVLKCVKDQNGNHVVQKAIERVPAEHIQFIIKAFHGQVHTLATHPYGCRVIQRMLEHCDETAQASLLQELHVCTIALVQDQYGNYVTQHVIEHGKPEDRAKIISLVTTQLLPFSKHKFASNVVEKSITHGSDEEKREIVKVVTTIRSDGNSPLQILMRDQYGNYVIQKLLTLLQGPDRETLVEQIKPQLQALKKFTYGKQINAIEKLIYNSSTPSQTASPPPGSALATPPLLTMDVQSPDSSAPPSTEASTTEERPVVDKSSEGTKKEASIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU92</accession>
    <name>A0A2T6ZU92_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1125670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU92"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU92"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="204"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="355"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="588"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="72762" checksum="41399A89831C9050" modified="2018-07-18" version="1">MMKVGRSLSQLVDNKRTRESKTRSVGGRGGAQAYREKSFFSFEIQGIRKSLKGDKTDTFSGPKASHLSITPKPAITIQPPKKVGPSSQYYRVIRALFDYTAASDQELSFSKGDFFHVIGREDDPEWYEACNPASNARGLVPATYFQTLGKSGRGSQDSAASGASDILRTDSGYSDRGATAGSQERVTSSGTDRPRAMSTSGKSGSPLYGVVQYDFAAERADELEAKAGEAIIVVAQSDKDWFVAKPIGRLGGPGLIPVDFIEIRDMVTGQIVEDTQAAIARAGVPKVEEWKRMAAEYKNSSISLGRFDFDAPTAQAQGQMQNMSISDSQNRHTLQGHSNGGPPDQYRHSGSSSQGQYLAPVVASVESYSFENGRYWYALNATMEDGRSWILCRFYEDFYDFQISLLDEFKEEAGHTGQPRSLPYMPGPVTYVTDTISAARRTSLDEYIKKLLGMPTNISRSKLIKQLFAPRPGDVETTGYRQSQVSLHDNRRSTASQQSSDSSREPSRQSSQHNLDGTNGGNGYPGLSAPPPRSSGQQPRMGGSNGISQAQQVHIRSASDLQPPRMLRQDSSMSSATQGSNSSQPGQFMKVKITYSDDLIAIRLPKDVSYVQLQEKLQERLRADISSVRYKDEPSGTYVELLSDNDLAIALSRNPKLWLHVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUC0</accession>
    <name>A0A2T6ZUC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1101020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUC0"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="132"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="408" mass="45612" checksum="31C4F1E2FCBC70C7" modified="2018-07-18" version="1">MAATTGRKTKLLIDLFLLAATQVSAYYLVKWLISYRDPDREKRDMIKKKSSAVLRRLDDNHQRQGGKGRLERTTFTSYEQTILTEVVAPEDIHVTFNDIGGLDSIIEELREAVIYPLTVPDLFSTSSNLLSAPKGVLLYGPPGCGKTMLAKALARESGACFINLHISTLTEKWYGDSNKLVSAVFTLARKLQPTIVFIDEIDAVLRSRSSSDHEASTMVKAEFMTHWDGLLSSSATTGNASQILILGATNRIQDIDEAILRRMPKKFPINLPSAPQRQRILLLILKDTKLSSNFDMEELVRKTAGMSGSDLTEACRDAAMVPIREYIRSFTGDEGKRRLEAGGRGGISRDEVRGVENSDFFRKGTGGRRPVEDEVMEGFERAVGEVRERIEEMRGNEEFREAEEARVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUF1</accession>
    <name>A0A2T6ZUF1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1177028</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUF1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUF1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU79120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="417" mass="46461" checksum="3D28D31B797D1F08" modified="2018-07-18" version="1">MMQFYPGNKTGGIPGLFGDPYYWWEAGAVFGSLVDYWAYTGDTSYNPTTTEAILHQVGPDKNFMPPNQTQSLGNDDQCFWALTTMSAAEKRYPNPPDNLPQWLSLSQAVFNTQAARWDSDSCGGGLRWQIFQLHSGYAYKNTISAGCFFQLGARLARYTGNSTYADWAEKAFDWTYNVGLATRDNRFLDGATAPKNCSDINRLQWSYNAGMYMAGAAYMYNFTNGDVKWKTRIQGILNGTLQDFFTRPPIGPENIMYEVACEPYLTCNVDQRSFKAYLSRFMALTVKMAPFTKDTIMPVLYTSAASAAKQCSYGDDKNTCGQKWYTNEWDKLWGVGEQISALEVILSTLIDSLDPPVTQAKGGTSKGDPAAGGGDGWVNSKGEFVPHTPNRKDKIGSIILTVVVILGLLWMSWWMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUX0</accession>
    <name>A0A2T6ZUX0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUX0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015718400" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="10013" checksum="F467E88F06DA659F" modified="2018-07-18" version="1">MRSTRRPFLFFCFSFFQIIHSSFDLSEKLLKRGKVGEEKCMLSQVHDDYITYELRNLRIFFFFPLRKKKKNRADFKQQTCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUY6</accession>
    <name>A0A2T6ZUY6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_839984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUY6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="21497" checksum="D5E3C4C566A76238" modified="2018-07-18" version="1">MIMWVTDHFTRVEILHLVAIFYPGGALPSRRDGGRAYIGCVLEDCKIAGIYLGNSISCMHQLEGCIDLEHGGRLPGSEMLPSPMSIVLMQEQAVLPPELPSLPEPFPLPFGTQRATIKFLFSSLCDTPSQLKCNQMYKTIARHRCTTPQPLHLSSRPSHTRFYSRSECNIRPSSPHIWYSQESGCYCNPVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV30</accession>
    <name>A0A2T6ZV30_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV30"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV30"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="408" mass="44272" checksum="9282B979DADC569A" modified="2018-07-18" version="1">MPRALPWARDRSSTSASSSSKPSAKPPSPSLKANPKRSLSTSPPRRNAPKKKGSAPNEVIIEYMTPKDDVYIMVEDELLTTAQLYTRSLHRAEYNRLQAAAALKNAHRISDIQRPVDGVTRMSREAIMRERRGARVAALGLDGGGSSSGEDEEGWIKGALGRLMSGKGSSDGYAKGRLGERWKDRGGRGGTRAAAGFTDSQAVGGRPAVRGAKVKVEKQEDDKDIMAPILRFREKEKGSRNTNSSIPAVGVKVKQEQASDTDTPSDDDLDAPVHSFRTPSVPPLSSIPSFTNNRNQAKLIKRRDSIPPSTVSTTTSFSSTTTTSASHTTSAPQSRATSFSKIIDLDDDPLFMLPKPLEKSSTYRGKSMAARRRAEGENSGNGIGGGEDLGDRKERERERRLFDSLKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVI9</accession>
    <name>A0A2T6ZVI9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1114417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVI9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVI9"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="111"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="21816" checksum="D9E5F3159BADBF7D" modified="2018-07-18" version="1">MGQSQSTRRSEPGASYRAKAAAEAEARADASRKSQAAFKTSSYNSAKAYSLSARKHQQKMSEYNALASSEIFRHYNPNYPTAATNSSLLASSFFGTFFSLFTAGPNDLSQLDLHGQHVNEAIPMVKDHLERCRREGAQRTTVITGRGAHSVGGVAKIKPKVEELLVGMGVRYRKDGPGAFVVECGRLDGGGIVGWILRGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVM9</accession>
    <name>A0A2T6ZVM9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1125053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZVM9"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000452">
        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="954"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="1264"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1071"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1424" mass="152863" checksum="A71216B8BA9289CC" modified="2018-07-18" version="1">MSHLPLHTPPTPPHFGLSDRGFPERSAQDRLRVTESSSTSSLNKHYSGGNNTTGTLSHSNNNIHPPSPNLYTLQVNSQSEARTVYTHQGYPSSPRRLPPPSQHLQRDNLITHQDFDREINAGNNNSGNNGAGGLIAHQQVSFTHPQRSPYPPSSPHGRHNHYSLQSTTLSRTQQDQLERLQPEASSVTGGFLGPLGNDPSHRYDSGPSSPYSVSRSLSGGSSNSVHGTSRDKGQPLLSVPETSSSAATTPAASPSMSSTGFPRSIPRTSSIDSAISSVSAQSGANHTTRDGNHSSAKDVNPTPAEIQSLIQTAGSAESLIAYMMKEKASAASQNAQLWKLVDKQRAMIYGLNKDLERALKDKEKYRKALKEQRSQIPLLLASSMGTSRTSNESPAPSESAAGDSPQDGQPKANPLVRSESMPLPGRSGPDSSSVQGGSMAPYQLTPPLGQELDGPANSMGDRLPSSANHGPRGPNGQSAPSNVTPPLGNKHSDQMLGGQGNLQSGNPLPPMMESAEEGPAPLSKLDNSYPAAGTGPVKGPIPLRMKLGISTAVAPASGLGKSPLRKAPPAPLSLGLHTESKLHDDTDEDDNVSIDEIVGYQQLSSRKSKEPEGKGSDSDSGKSWQHTPVDKKAPSDFSSPEIEVHKSVSPTQPAPSPRPQEKQALPPSTLRKHSEGLLSPTAVGFGKEQSVVSPGIRQQFARAPLPSPGLPNSPRPIDRPLGSPMPRIKSPGLPATPRMSANQVPYGPGTPRMGMPMSASMPPRTSDHKGHEKNASASSLSSASGFAKPGSLDRLSNLLILPSAIPSVDSRVVSSRMKPARASMMPGSKPRPLSEDSVFTLGVFSRADGKELLRVEKDVGALPALDSRLRNYITYNVKVPDRSLFSGHAPAKIDARRNAIDEYFAGVLGATMDERAALALCEFFSTDVVDNSVGRDSAPIKDGSGITGTNQDGKPVKEGYLTKRGKNFGGWKARYFVLNGPVLKYYESPGGSHLGQIKLQNAQIGRQSQNQKVKETAEGANDADNQYRHAFLVLEPKRKDSSTLVRHVLCAENDAERDEWVEALMQYVDKGGPDDDAHSTMSQVSQTSTTGREGKKKRYGQKHKDSREKNDDDSLQAVSYEETAPGAAPARGPTPEEFNRLRNTPSPQDSNVHSLSASQSAPVLGNHQQAQATENRPMVGPVPDRGPVASKQISGPTNGSVISDLAAWGSKFSAPTSHAEQKSVKKRSIWGFRQRSSSDLTNQPQAQPQQVYERIPVSRSVFGASLEEAVHLSKPMGVDVHLPAVVYRCIQYLDAKDAASEEGIFRLSGSNVVIKGLRERFNTESDYNLLGHDEYYDVHAVAGLLKLYLRELPTNILTTERRGDFVKVTEMDDKAAKISALNELVHTLPIENFELLRALSGHLIHIVENSDINKMTIRNGNPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVW0</accession>
    <name>A0A2T6ZVW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1081275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000086">
        <property type="protein sequence ID" value="PUU79612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVW0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015476706" evidence="1">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="70" mass="8215" checksum="A0DECD927D65280C" modified="2018-07-18" version="1">MLELLMLLVILTISHDIYRTCMHASYPAIIQTKKFTAYARRVDTSENEFFYAVKHTPLSFDKLRICACDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW58</accession>
    <name>A0A2T6ZW58_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1124812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW58"/>
    <dbReference type="OrthoDB" id="5424754at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="130"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="462" mass="51687" checksum="427778A78DAAE4DF" modified="2018-07-18" version="1">MELNGQEHLEMVHLSDDSSDAYQNLDDAEETESDTEPDIETLDIEEGTALARRHGSQAVGQQRNSDPITVRISTTSGFITTSGVSNSSPRSEPGIPSYGRIGPAIDSQRNTVIWAEGAILGKAKALMLRYTRFDNPLPNAVALTSQVYTVWSKVQDTISDAGYIDPSEENLNLLRGKYTAVRGQFLFHIRTNIKGLYSLPKDPTAMVPRIEYLLEGDRFMCSSNGYENLTFRFLAPQIANAIYGKYFDGVKMQGMLDQGFLKRINGNIICLTCAMLCHVLRAWQTGIFKTPAQFKHDVVRDLFVRQRNTWLGFAKETQKAFVLNLHWTMTRRLENQHSIRPERREGFTEDNDAVYAELQHQLAVRSLPVGWGQDSLDPLQETDTSLDFSQMSVDLESGFLDSDPAGPEDGCRQTEELGLEEARSPDPSSPLSLSLEYFEAGEVSPGGGVEIYNRMPRVGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWC7</accession>
    <name>A0A2T6ZWC7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_977975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWC7"/>
    <dbReference type="OrthoDB" id="76215at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045026">
        <property type="entry name" value="LIMYB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47584">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47584:SF14">
        <property type="entry name" value="L10-INTERACTING MYB DOMAIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14204" checksum="1E70B02BF0EBADF0" modified="2018-07-18" version="1" fragment="single">KENSGFEWDGERGLPTAGEGVWDKYITKHPKVAKIRPKALSFYTVMNQICSGHTANGHYASTMMEAIIEGVEQQTGSDYSGGRDTPHDVDFMFRGEGGGESSEIEMKIMSGGSIQGKGKGKRISEEKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWD5</accession>
    <name>A0A2T6ZWD5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1107462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWD5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWD5"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="432" mass="49464" checksum="B6FD7A60C12888C7" modified="2018-07-18" version="1">MATGFAPPPQTFAQDDVQLSYNDYQDDLMDYEGASAILPAAQQQVQAQNNGDEAMELDEPISRNDSLASEKVHLRGVDNMKTSEVEAFASEHFQPAPTRVQWIDDTSCNLIYESPDIALAALSSLAAEPAELPVLQLRPAKAASLHPDSRLHVRIASVDDKKEPGARDRSRFYLFHPEEDRVEQMERRKREGTRRREDREYDRRYFDSREHDRRRKHNVEQFSTDFYDDDAATRESRNNNRQSRSYDRSRSISPRRRKNIELFPERKREPMEVGPRVRVTKELFPERVGSLLSRDRDRDLLSTEREGSGSRELFPNKLGSQRFRSDRSLSPQKGISPSPPSPPGRGGSADRRLEKLEDRISMPGRSLEDRINLDATSNGGEGLKIRGRGMKRDNLFAEKLRASKGEELVFEDSGGGKRSKGRRRDKAEDMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX77</accession>
    <name>A0A2T6ZX77_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX77"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX77"/>
    <dbReference type="OrthoDB" id="5407781at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="34903" checksum="60CBEC44F5FE7A02" modified="2018-07-18" version="1">MPDVNKLEAAAATTTTTTSPPAIQSTFTTTPTSTSPPATTTGPATTTTTTMPRTSTEAPSPLPSPIFQTSRPTTPSPHASSSNLHHYPPQHHPSISSRRPSSSLSIGSSSSRRPSSSVLSPSSVDQSLPQRLPRQQTAQEAAAFAELHQELETEQEAQVNRLLNMIRLQQLQQQSLNQGSSGSVIDDNCSTAATIDSNSTLGAAVGGGRALSPVSAYSRSGRLSRENSTTSASRGRRRRSGSRASTTTSTSSPSFPTGNFIPDNASDTSASVPWLGSSHSDMGFYIAEAQMLTRENEMLKRRIRELERQVSELSSKSSAAGSDVASPGGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXH1</accession>
    <name>A0A2T6ZXH1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1079935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXH1"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015526425" evidence="4">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="148" mass="14963" checksum="F055E2D2D6A25160" modified="2018-07-18" version="1">MQFLKSILLLAATASLTLAQTTGIAKYDNTYDNANLSTLSVACSDGSNGLYTKGYHTLGSVPGFPNLGGSGTVAGWNSPNCGACYQLTYTPPPPAAPKVLNIVAVDVAAPGTFVLSQAALDTLTGGQAVMLGSVSVSWTPVAASQCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXJ1</accession>
    <name>A0A2T6ZXJ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal C2 in EEIG1 and EHBP1 proteins-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1079997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXJ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXJ1"/>
    <dbReference type="OrthoDB" id="3365224at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039931">
        <property type="entry name" value="EEIG1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456:SF1">
        <property type="entry name" value="C2 NT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21456">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="403" mass="43963" checksum="34EAEC60209B4918" modified="2018-07-18" version="1">MQSFGMLSSYSTLFSPMASTEQTTTFLMSRPTPSSTFSSTSSSSSLRRGLLTKDLSFDGLIVPKSRRPKFDLTLEIHDLNNVPLVSGQAYVKWHIGGTSRADFRGRTNKENIKEHKVNWGYTQVCPNVRMTVGRDGILQELPIVFEILQEYAGARERIALGSVTLNLAEYTCVNKETRRYLMQDSKINSTLKVSISLEQVGGDSNFESPMLRGAQVFGGIAGIIGESQNQEDTGCATVATSQKRETSAIQDMYRCTLAASWQLQAGELHPEDCIEDIFAGGDGWTPRSERGRAGKAKSVRYEGGLSRGGKGSDSDSLSAMSAGAASGTSSSTNHAATQGHANTKDARRRKDGDTLSIMSNLTGPKVERKESSRSTRSAHSAYEVDELRAREDLVSWRMPSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXL4</accession>
    <name>A0A2T6ZXL4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXL4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXL4"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31024" checksum="8CA91CE543989957" modified="2018-07-18" version="1">MTLPYPLRIMAVSSLQGGGRFHQYQMPHYITCHMQRSASPQSSEWLASPPPVARNQISNQISNDADVPLDLGHAYSKPSDGALAGSEGVLRMLPERRPITTLEGACPGWHRGVIDERRGGVNERAVIDSSDEDGTSSVEASVGSNSPVGEEEERRGSAAALRNGSGPSSKSSTARTEGTVEKGAGLWAIPLGAEYVEDKYKFTDCCGGRTTILRGEYESIVKEVEEGSKPVQKYLVATGLSGEAQHALEWTIGTVLGAGDTLMAIYVIDQDTVEDGGKIFPDDKIGGELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY54</accession>
    <name>A0A2T6ZY54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1079604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY54"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="10756" checksum="8CD9B52A6E644196" modified="2018-07-18" version="1">MLATRIVLCVKVGFSLPPCSPQRPSARDFSGLCSSVLKASSGKNQSPAIMEINSENTQTIRKHSTVDYRLIHCSRPFLYRSGRAHRTTLVTIHKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY65</accession>
    <name>A0A2T6ZY65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1171927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY65"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="7733" checksum="2C3CEF28DF9C33E9" modified="2018-07-18" version="1" fragment="single">MRKAPGLILRTCSTSSTSAAIFVPLVTGPRYSSGMQHQGAGSKLVSVSFHIIGTTEPCQRTHTNTDGANTLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY69</accession>
    <name>A0A2T6ZY69_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1123694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY69"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY69"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="162" mass="18647" checksum="F759670D81C6B664" modified="2018-07-18" version="1">MVDIICIFTDTFDTPDNNEQLVERDEKPLQPGNYFIVTNGSIALTEEAPLLRALSLHSGSRIVSFRDAVRERDRRCVIIGLPVLRPDVWGWDFFHVAHIFPLAYEDHWNQSNFSRWITVPPANESDGSIHSVQDGMLLTPNMHALFDAYIYQSIRTYEQLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY76</accession>
    <name>A0A2T6ZY76_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1123604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY76"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="287" mass="33008" checksum="6617E4009F26F421" modified="2018-07-18" version="1">MRCFLKTPTGLATALPAARFLNLTHGSRRTHTTLRTRTTMPNNKTVITETTMPTQEIGLADTPAFQQLKAKWPKRYPFLDDALLNLVIECETRASKLYDEKLATVLNHFESHVEARGNLPPFLQVRQKQYDDEIKELILDKRDLLSAALEERTERLKSDNMYNVHGVLDRIVYAAKLQKMVPPYAKMQEGLDWLALEREFTTVLNKEVQRRQLCFKDVMACVHRLHSEMCDRFRGAGNVDNYGSVIFVRDDKFSDNERAALVSFLKVQSSWENPVNWEEVTGCKGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYC2</accession>
    <name>A0A2T6ZYC2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000063">
        <property type="protein sequence ID" value="PUU80493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYC2"/>
    <dbReference type="OrthoDB" id="10418828at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="309" mass="35088" checksum="0619CC2ED033A59F" modified="2018-07-18" version="1">MSKNAQLLSRIRELQHIIEARYKEEKHARQISAEKEQYQRNFIDYQDYQIRAQAVRIELQETKIRDMIEKHARDCEDMRRQMNFLRGIAFGRDGIPAVKERVECSHWEFSAEADHRAESELAPGEGARPGYRVPENLSNNLDHEGNYDPTPAAPPACPVLSLDPPLGPWSLSKHDIELLQEIGFNIFPECLAEGSPQQPQGTAHQPNDWLYTQEQSPEDSLEAGDAPKPIAPQNLTRGLEGCAEESTQGSKNGVRQTTYRHHRWTQFTEDQPSGGIISGGVAKPNHRRKGCWEIPSKENLHAPPYQTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYT8</accession>
    <name>A0A2T6ZYT8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_974225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYT8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYT8"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038:SF1">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="118" mass="12547" checksum="CA10823D3C9BD5EB" modified="2018-07-18" version="1">MSNKNLKDQRRADLIIPYVAPTAKTNEKKKATMTSTLPMAAKRENKTKCIRTAMIFAIQAWLNETPAQLAGGKQPAYFGVGMSLMSLAFAYLPLFVPGMGAGPLGMGSTVAPAEATPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYZ5</accession>
    <name>A0A2T6ZYZ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1170580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYZ5"/>
    <dbReference type="OrthoDB" id="5338512at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015694133" evidence="3">
        <location>
            <begin position="32"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="486" mass="53223" checksum="61E4E2E1A71CA2BF" modified="2018-07-18" version="1">MKTYRPPYPSPTFMISLTLALVTINLQTTSAHSYSTGPTIFRRQLPCESGESEGPPVLCEVKNYCCPSGSRCISIENNTSVVCCKNGEFCNEIFPINCESTPSPTGVPASANSSSKAIQCGRLCCPEGYECGPDQDRCLMKKENIPDDARKHLEEQKRKEKEKDRANCQKFYKENVGRGKHLPKIFYAKAILAGLFPGIALGVAIMFGYTKMVEMKTRRRTINFNNPSPDDINWAERRPYMQQHESIAVGYSPHLDLPGPRNISPSNWKQITPADLSPNLGPTIPPRERSTPSDTVESRMANSRTTPIQTTLPLHPLAASPLEPRAQSSPRSSTYSETDHSESFLSSTISNARASSSTRDLPPPDRASNQRRHFSSEVASVITDAGTGFSDMGLNSQAMTEKERGRGRSGISTETGYSDSEYQDGSSVLQPFAFEDEVPPLHPTRAQGPLSAIREQSPFASPFNPNSPATQSPFAGGTPPSRFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZG9</accession>
    <name>A0A2T6ZZG9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1063107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZG9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZG9"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="337" mass="36109" checksum="0B09C8D40EFB9015" modified="2018-07-18" version="1">MSNLRRESSQEQVLQPNLYHDLFTSPRDIRADYRLSSAFAGRIGGNQRFTISRDDPLFDQIKKDIPDATTDGTWKELCDLRGLAKKDIWKSAIIEFWATLFNTLISGAAGISIAKYGTQYNLSPTTMAAAGGLSILFSLPLFIHAAGPASGGHINSLITIATFTAKLAALPRAIVYVFMQCLGAVAGGFLLRAGLGEADTVGAVVPGCYWAPNAGITNGQAWVIEFSACCTVLFIAFGVGLDPRQRDIFGPALGPILIGVIVGITEFITGIMKPGYTGASMNPSRCLGLVAATQTFRGHWVTWSAGIAAACINGLFYVLIPPYHAEQARDEEKGKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZL4</accession>
    <name>A0A2T6ZZL4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZL4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19909" checksum="128E2B77DA609388" modified="2018-07-18" version="1">MTPRRPSQTNQQETIFGTPPQGDDPRISYPLDHWHEERKGERRGGRIGDEINANLNRRFPRKAYVSTASFTNESSWIGDQEERRASNSIMKHCVQPEFCMAQVGMPPSTTGKYWSNHEIPIRNIEEHLLQVDVEVLASEIEGLKHLGRGPRSIVIACSDIIKLSNGTRGFYCVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZU0</accession>
    <name>A0A2T6ZZU0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_972785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU80996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZU0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZU0"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="15"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="87"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43251" checksum="E2505B2E0124E305" modified="2018-07-18" version="1">MLDEGVRKPDTGFVAGCDCPDGCKPESCLCNVDYRDLPSEWLVDRGFAYDDNGRVIRPNNIGITECNMHCTCLEDCQNRVIQRGRTVELQIFMTKECGWGLRTLEPIPKGTYIDSYLGLVITRTEAERREAGYRQSGLSYLFDLDFFEKHNENVNCGMEKPLEALEIGGDPETPDEESAAAQQTAPLQKKRRRANYFGGPRKRRTKGPSTAKANKGKQIKEVEDLSEYEEIRDFKVKQEEVLFGTEEVGESSRSARSRSEVSAGYHHERSTSTTPVEYTPQSYSLDSKDMGNVTRFSNHSCDPNLDIYSVVIGSQEIFTLALFANRYIEAGSELTFSYSGNTGLERAKKMKRQLKKSTKSSEDTELFRCKCGTRKCVGYYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZW9</accession>
    <name>A0A2T6ZZW9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_663176</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZZW9"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1059"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="107"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1088"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU81026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1354" mass="152928" checksum="EEA33336DC0FE013" modified="2018-07-18" version="1">MATSSVRKLDPDQFSGQRGVHFISSDFPSDVHRLSGSLDGVARPSHQDDSASSDDSQRSGQQMSVEYDELDLDVDEEALVSRDDITPIHNGGYSSWAGSGKMGNGVRSLPYPLSEPSGRMSPEGVVDRSSLQRPSAPIRIPSHTYAPGLHRHPINMTNERSRHRSSSATRSRRDPSALYRSQEKAYVQRLRQDPNSDYFSSGPGILGAYQHEFEMEDESPSEVHFGEDMYDGDTLLLYGHDEMEPSAEELKIPENRERLEWHSMLASVLMGDVVKQEKKRLIGNTEGKEGVTMKAELFIGLRAKVCGRSIPAQRRILEEGRAKVDTLIGDIIRFEIQGKDKTEKSPREQVQGIILRWEKCEQLWPTRAAMIKAKPDCASSSFTASWDALVAWNNITELINTELKILQNWVGNDDLNFARPNANSASDVSSIDRESSFLDRILKEDNLKSLIGESNMLLGLSNVIGKAKKTLIEYSEAFRKRHLPPYVEELLHLIGFPTRLIEEVIGMRLKYAENMREPMAMMTDQLIMQFQSVLQLAVKIKQEYMVISEPEPGWDLPPCMDENFEQVVLHGLRYYFKLIGWRIGSNKNTFKEAEILETEWHFSNDIGRFIEGGDVEVAEQFSSLTSRLLSRLMGHFEKELQKPPETRGEDISKRYKQILDSVRVRQRKLFRFSRLLSQRFENASEYSVEKDKLRGLVDSLIESGHFLVYTASVEHEGVYLVADPSLYERPHQIQSILRTCFHDDAVREDPSCPYVLVICPQDQLTWDGLISNIDMKEPIVDIKPGRLRLVADGSQTRLANARASFSHSTNHSLDILIEQRANLPRVNQELMKIKKTTYRLSNTIMDSVEKIRRQTAGLGCQELIQTCFAFATEFGQRSVLYMDNNRKAMNNLKLTRLAIDWVSFVCDDCVASNRMTFRWAVKALEFAMVMTRGQNILSFSEVEYERLRSKVAGCMSLLISHFDIMGARSTLAAQAEKQRMEILAGQAKKMDIGEFLEGNDDANHVREEWLRQLAEIENARKSLLSERQTLGRVLDDSNQTDRSLTSLSRSSFSNVSLRWQQGPFVGGGTFGTVYAAMNLDSGYLMAVKEIRLQDPQVIPQIASAIREEMQVLELLDHPNIVQYFGIEVHRDKVCLFMEYCSGGSLAGLLEHGRIEDETVVMIYTLQLLEGLAYLHESNIVHRDIKPENILLDHNGIIKYVDFGAAKVIARQGKTRGGGATTAVRTNLNSMTGTPMYMSPEVITGSDKGRHGSIDIWSLGCVVLEMATGQRPWAILDNEWAIMWNIAAGHPPQLPSPDQLSQSGIDFLKKCFERDPGIRPSAAELLQHEWILTIRNQVIEPSIPASETSSGASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZY9</accession>
    <name>A0A2T6ZZY9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1122652</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZY9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZY9"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10200">
        <property type="entry name" value="Ndufs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU81020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="11264" checksum="780E7DB87304CC68" modified="2018-07-18" version="1">MASGYGLDGGVSRCFPFWQDLLSCYVVNTGSTTSDEGKWKCVPQRDDYYECLHHKKEMRKTQAIKAAYNRRLKQDPNFDTRKPEGEADVRSLGLLQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A091</accession>
    <name>A0A2T7A091_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">B9Z19DRAFT_1077733</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A091"/>
    <dbReference type="STRING" id="42251.A0A2T7A091"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="46"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="486" mass="53124" checksum="DEBE6172DD91AC4F" modified="2018-07-18" version="1">MKPIWRLRPRTAIPHLRNSAQSQFTALRYSPVPRTYTTTNVLENLYDVVIVGGGPAGLSLATSLRSSSVTSRLRVALIEGLDLDVGRKWKPSGESYSNRVSSLTPGSVGFLTDIGAWKHVQRNRVQAYHGMQVWDGVSGSRIEFNWDVKNSSTIAYMTENVNLVHGLLSRLEELGGAQLIDKTRVEGISFGEDHGTLDLRTWPVVQITGGRKLAARLLVGADGANSPVRTFAGIESRGWDYGRHGVVATVKTEDMPSVERTAYQRFLPTGPIALLPLPENFATLVWSTTPEIAAQLKKLSPTDFVAMVNSAFRLSHVDIAYMAKMDGGISQEYQWRQSVTPIDSAGVPSTVLEVQEKSIASFPLKMRHADSYISERMALVGDAAHTVHPLAGQGLNQGIGDVQSLIRTLETAVQTGKDIGSTLSLESYYSDQYFKNNLMIGVVDKLHKLYGTAFPPVVAVRSLGLRAVNAMEGLKSMIMKQAAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0I1</accession>
    <name>A0A2T7A0I1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1099803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0I1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0I1"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="306"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="485"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="735"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="859" mass="95859" checksum="178E2CD4FD93AD7A" modified="2018-07-18" version="1">MSDEKRSMLGSSLPIPTYEEATSSRAHSDAGDNPHTNEEASHLLASSHGRYRQPTVETARSSLESSFLEEFGDSARSSRESLERVMVEMEILEPGEGEEGQQSRRRRGRLRMHISKRISSITDSLSAISIPHHWRINPFRWFSCIRIPDLPCFGEGFVPLYRFIGVIVGLIVVYALLASDSVTLNPPPGAGTVEFEINALRDFIRDSIDKDNIEHYLEYLSRFDHTAGTEGDFVLAKYIEAKFRSFGLESVGLDEYNVYLNFPKPGGRKLAIVDPPWEAAIEEPKTNGDHENTPAFHGHSKTGSATGPLIYANYGARADFDKLESQGFNLTGSIILVRYGGTQMDRALKIKAAEERGAAAVIEFSDPKTEGWDLPEGFVQRGSVSLMSFMVGDVLTPGVPSKPGYERIPLEHNPGLVGIPSLPLSWDNAKHLLQSLKGKGTKAEESWMGDTRGVEEWWTGSINDSPVVVKLENDQVEDERHHIWNVLGYVLGSDDRAKRIVVGNHRDAWCFGASDPNSGTAVMLEVARLFGKLLEMGWRPQRSIIFANWDAEEYNLIGSTEYVEDNIDDLRLHGMAYINLDIAVSGREFYAAGSPLTQQPLLNVLERIQSPSGNSTLRDDWGDKYLPGLGAGSDYVAFQDYAGVSSIDIGFTGDPFPYHSCYDTFEWMKNTGDPGFNHHLAIAQVLGLLIIELADTPVLPFNMVDYAHALGRYTDDLEEHAREIMQAQSPDTKPLDFKDLRRAVESAEKRLKEFDEKHENWMDYVGTGLDMNGIIARQGRNIRMSNFEEHLLDLSKGGGLPGREWFKHVVFAPEAWSGYDAGYFPGVRDALAGRDWELAQKQLEKIAKVIDSASYKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0M5</accession>
    <name>A0A2T7A0M5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_972106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0M5"/>
    <dbReference type="STRING" id="42251.A0A2T7A0M5"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116187" checksum="CD355C301547BFB2" modified="2018-07-18" version="1">MSTVGHRQAVGPYQQPQEMEEKARGRERNRDGMMDGSGGQATGGPLSSSSDPPSRKRRRSRKGLDKKFECPEEGCGRSYSRAEHLYRHQLNHQPKQIYFCDFPDCKRSFVRQDLCMRHRDRHTNRPGSQLQRKDSLLNNPAAAAARNILSERKSSMSKGSSSPESPNGPGLMMKGGEVESPIMTPNGVSMNMTASPDTSLSSTTLPNSSKISLVDVGALYGGGQQRPGLPSSKSDFARPPLQTSMGPNQTINGMNMQPLSASSVSSGGHFSAHPTSATTTGSSMAATTGTSAGPTYVPQTSFAPFSLPQPAYPNLSQSSAPNPGPNQYITSPPTSSSSVGASNSIGGVTTTDVEFESIGLPFTMPVFGGDGYTRSPNWMANDFATWFFSEDPQVPGTRTSSIGGGYIDGLAMGAQNFYIGGQEFQTPSFYPLQPQHPMAVTSLIAPPSPPQESLLSEHKRQDLMDLIENYPEMSDLPQRSSSLMLNSTEDDSHPLSLHMMQSYISSYWLHFHPQLPILHRPTFSADKTPNLLLLTMMAIGASLIGTKVDSSVAQAATALSVILAWNLRWQIFSDVDFRPPAKLWVFQALLLLETFEKMFASRALHERAHIHHATTLTLMRRGSSLTGRCAYDSPQSGRDVKSNSESGSAAFSGQSSGPAPVEDAWNRWIVSEATRRAAFAAFVLDSTHATMFGHSAVLVAHEMRLQLPCDETLWAATNGAEVFKIEHSLLQAGVKPTTFLDGLKKTLNGQNVRTNSFGRTILMAGLLSVSWHMAQRDLQVTSLGVVAQLGGKDKWRQALTRSFDHWKKDFDSALDGIRAGSSTYEGSNYCLPSTEDVEHETTFESRNVMHHLAHMSMHVDIVDLQIFAGAKRLLGRTVIPSDAAQVRKRVKDWAPSARARDATFYAVQFLCQVLLPEERVDMHYTADDDDIGAHRKLSSATTGVPIYSARDDHLLNRPWVLYYASLVVWSYGFALEGQLQVSRSHFATPAARYQDMRTFLRRLGGVRSPEELANVRDKNACLGLLLTLHSMFEKARWELLVEASKLLNQCVAISIGEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0N9</accession>
    <name>A0A2T7A0N9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1191256</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0N9"/>
    <dbReference type="STRING" id="42251.A0A2T7A0N9"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008724">
        <property type="entry name" value="PRK11720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="209"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
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    <feature type="binding site" evidence="15">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
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        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU81290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="382" mass="43233" checksum="439DB6586576BEE0" modified="2018-07-18" version="1">MSDREVLDDISHRRYNPLRGSWILVSPHRTKRPWQGQKETPSKTSLPVFDSSCYLCPGNLRAVGDTNPAYPETFVFVNDYSAVKEDQQDYVQPESGDKSSLLLQAAGVRGKCYVICFSPSHNLTLADIPTEMIVPIIKTWTALYASHLPKSSPYYQVPAAELGITVPGDQYTYMQIFENKGAAMGCSNPHPHGQVWTTTGIPEEPSLEIQNMKEYKRKHGAGLLKDYVDLEITKEKRIVALNDHFAALCPWWAIWPFETMIICRREVHSLPELTEEEQIGLAKVISIVTKKYDNLFETNFPYSMGIHQAPLDGDPEDRKACHLHLHFVPPLLRSATVRKFLVGYELMAEPQRDITPEQAAERLRNLSGDEVYRGNLVCCPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0U5</accession>
    <name>A0A2T7A0U5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_971931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="212" mass="22976" checksum="FAF400F76DA350E1" modified="2018-07-18" version="1" fragment="single">MGDIARRAAETLALVARLQPSDTTAATSQATRALFAAYYPIIQEYTIICREALREALCYYHVTSKTTYILCQSATALLTKGFCMPEEKGQGEETGGANGLKSGTGLGEGEGADDISKDIKADEDLSELAQEKNREEREKEIENERDAVDIESEMEGELGDMSDKGEDGGEKGSGNEEEDDMDEETGGVDDLDPTAVDEKLWDGKGDDNAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A102</accession>
    <name>A0A2T7A102_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A102"/>
    <dbReference type="STRING" id="42251.A0A2T7A102"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37741" checksum="30ED8A9D9A34A99D" modified="2018-07-18" version="1">MDVGVLSKVVKSLFVHFQMPAVMLLQEPVMAVVGAGVRSGVVLDVGWNEAVINVVYEMRVVGTGRRSRRGVRTYRDIWRKFLQEEYSSSSSSADGGNGSDDDGNEDNEIEDWEIEEILTRTGWCQSFSRSTSHHKDETAITIPLTTPTPPSTLTLPFNKLATPAEKTFFATTTTDSSTPEYPDDDDYALPELVYRALRDCPIDVRAAVMQRIIITGGGSYVPGLKKRVIDEVRVLVKCRGWERVGKRVVKKGQGKMLAQEVGEEGGYQWHGEDTASLEEQKDKSNKQEAEDTSGRGRIAGVESFGSWVGASLVAGMKVRGTIEVEREKFLAAVAAGGTGFPLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A163</accession>
    <name>A0A2T7A163_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A163"/>
    <dbReference type="OrthoDB" id="10446382at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="234" mass="25091" checksum="8994FC7149236AB8" modified="2018-07-18" version="1">MLVICLFAGLGALWKKGDRGKTDHSSLIKSTAQPSSAKPGITPTNSITITDPSESKLATRATTRTKRTTTVTSTIKTTLAPSADTTFPLWIGTFDSISPLVSFFGACKTSTSPAILQACDDVARFTTTIGESKPDGYSIGTTLWAFQDHLVPTERSGKQWYYSGVSVEKKYSHPSSSGCEVVEKAGMWLGEDGTYTLRVNYESTGACTLDNGRPKNPTAQVCECVYEGVFATLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1M3</accession>
    <name>A0A2T7A1M3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_895250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1M3"/>
    <dbReference type="STRING" id="42251.A0A2T7A1M3"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="11">
        <location>
            <begin position="29"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="12">
        <location>
            <begin position="173"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="27598" checksum="7111EEB56ED8F947" modified="2018-07-18" version="1" fragment="single">MDSLSQQRLSAILSASYSDAEIRNALQVLDSRFTENSPDSRRQLRVDVQAEVIQSNVHIIREFSKISEQLKLVGHTLNAMNNVVSSLKTHVTAASSESAPILEESSQLLTQKKNTETKEALLKAFTEHFVVSEKDVVILTSSAEPVDDRFFRILNRVKKIHGDCEVLLASENQRAGLEIMDQMTNHLQGAFQKLYRWIQRELKHLSLENPQINAGIRRALRVLAEKPTLFQNCLDFFAEARQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2P7</accession>
    <name>A0A2T7A2P7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1075956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2P7"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="377" mass="43173" checksum="FC26A79702C863E3" modified="2018-07-18" version="1">MERIHLFRNLLRQASILFDDVARAHTAKLIISGFRRNQKLEDAWTIHEKIKKGRQALSLLHRANAGKPKPLGKVLDLAYGRDGRRRHELLQPILDRATSSDPLIPGVPRTAPPPISDELMALMKHQVGTTIHRAEPEIPELNAWGRPMPKRRVANMLRRHREYVLARLLPPLPEETIQKLEKFVRGEEEPVLPRRKIKSSSSTQNSGRKLSPRFKRRAYKKIVINTPLMGINEKTQKPIAYWSDIVKGPPTEIGKLWDFEGLKKPEVQKPGKRKAKMLEEERSKRGEEAVLKAGEEESLNQRDGEVGSLKESEDRVSNEQEDVPGDSENRRLKEPEERISTEQEEVPGEAEEAYREVDGGPKEQSSKELDERKMEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2U5</accession>
    <name>A0A2T7A2U5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chorismate synthase</fullName>
            <ecNumber evidence="4">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1075714</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2U5"/>
    <dbReference type="STRING" id="42251.A0A2T7A2U5"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="401" mass="42528" checksum="F63AE24003AF72FC" modified="2018-07-18" version="1" fragment="single">MALSEADIQTQLSRRRPGQSALTTPRNEKDGVQIQSGTEFGYTLGTPIGLIVLNQDQRPHDYSEMDLYPRPSHADFTYLMKYGVKASSGGGRSSARETIGRVAAGAIAEKYLGLAYKIEIVAFVSSVGPIYIPGSLDHASSEYITFLSDLTREKVDTFLPVRCPHTESNDKMAQLIAEYRDKSDSIGGTVTCVIKNVPVGLGEPCFDKLEAKLAHAMLSIPATKGFEIGSGFKGTEIPGSIHNDPFASAPGANGILGTTTNNSGGIQGGISNGENIYFKVAFKSPATIGIDQPTSRYDGTSGVLAAKGRHDPCVVPRAVPIVEAMAALVIMDAVLIQQQRESSRSLLPSMPQPAGLKTTTVVDGSERKVDPANVPEAERTKLVSDPKGGQMVGGQGKVFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A344</accession>
    <name>A0A2T7A344_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1075666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A344"/>
    <dbReference type="STRING" id="42251.A0A2T7A344"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="169"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="335" mass="37284" checksum="47C6170272C1833B" modified="2018-07-18" version="1">MISLIEGPIEPVMGMAVAFHETTALRLAYDMKLEHNVPLDGSPIALAELAAKTGAPEETIVGVMRALTFKGVFAETAPGYFAHTSSSAAMGIPGIESMIGHYINEVFPSSPHVSDILRENNFEPPQDSRKSAFTRAFNTNKNFFEYIYTDDKPMGTRFGQAMTVVRDAHIGGGIGHIAIAAAQKFPNLKCVDKGIVANEGRDELPEELKDRVEFQENDFFKGQPIGGPGVYYYLRHILHDHPDPACKEILSHIAKAMDSSSRILLDEYILDERVGPEGDRLWIVKDYLMLVMFNSKERTETQWAALLKSADERLVVEKVWEAKNRSMGIIEVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A422</accession>
    <name>A0A2T7A422_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1061842</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A422"/>
    <dbReference type="STRING" id="42251.A0A2T7A422"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU82468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="259" mass="28332" checksum="9A7A6CBB708E7A35" modified="2018-07-18" version="1">MPQEPPPGALSSAFPPPPTYYTHFTGENLTALKSHRLEDGTPPAADSLPEPLCYLVPPPPPTGSYRAFGEEWMVPERYPSLEEAGIRQLYPPTSMAATAAANGGGGGVDKGKELTVDRTIELRRLSKSLLLNYLELVGVMGMAPEQFHEKTADLETILFNMHHLINEYRPHQARETLCLRMEEQLERTRRETEENKKAAAKVEDILARLELVAKQADAICAGDGLGVGSLGEKRVDDGVAKARVRDMEAWKALVSMGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4B7</accession>
    <name>A0A2T7A4B7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1190263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4B7"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="383" mass="43388" checksum="FB0CA20EF6C94D62" modified="2018-07-18" version="1">MVSPPSSMSNPDTSSAHSSSPPHPMTPASRRHSDGGAGNSPTTPATGYPSTTHKHLQSLFDAQTSDLDLTPYEKKVIAYLRAKTARPLHHPTEDLPSPQQLLEQQEFKRYLRFQEETTEEKDKFYFQSQEGHPSTIHNHPQSPYDIQTSALNHPPHEKNAIPKLTAKGASSLPYPIKDRPSPQQLLEQQEAKWHQRFQDHANEFEDKYFRQSLGCQAELYRCSDAWYERWEKKTQRIIEQSVEISAVLSGKTEIMRLKEIFNVRGALEYMVHYAKLIKKIGTDCPPGIQAGLNELAKAPEFTKALHDEVASHGLGLTAVTSCIALVYAKVFQHARGNDYIITLYKGDYTANEGAVLAAFLRMQSEWPYGLEWREEMGKGRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5P7</accession>
    <name>A0A2T7A5P7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_965848</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5P7"/>
    <dbReference type="STRING" id="42251.A0A2T7A5P7"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU83071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32121" checksum="D90BCA85F9D7673B" modified="2018-07-18" version="1">MALPIAATESTIATKNLTRLLSRLDSKLASQKATPLSPVDRAKFAANLEYARQLLLSLESESVLIRNTSTRQSVLSGLGVQKQAIRRLNEQLLVMAAEGEEEEGGDSTDDDDNEREGGGEEVKELSAFPAEVNGGKPPQQSENTPTSTTTTTSTLRNRFQPTATPTNHHQRKQLFPLPDSTAAATDADTEKHLSSQRAEQEHITADMLLLAQALKQSSLRFGSELENEKALLDMAQEGLDKNTLAIEGTGKKLEALRRDENVGLLWSILYPIIIVGLAFVVLFVLFFAPKLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6C2</accession>
    <name>A0A2T7A6C2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6C2"/>
    <dbReference type="STRING" id="42251.A0A2T7A6C2"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="37845" checksum="6D47497322B83620" modified="2018-07-18" version="1">MSHQHFDIPEIVVTEHVTEATEVHSTSFREPPAWKLNYRIGSGAFGTVFLEKVQTREMESPELWAVKRIPRALPNFPAKRYQAEVKNLQALSNHEWFVKFNSSYEVTDYVYIAMEFISIGDMSVTLVDGYRWNESDMRGVIEQLLHGLTVMHEAGITHRDLKPENIFLCLIEKETYALRVKIGDFGTSKRIPHSNASTYLKTTTGTQGYMAPEVHDTSIPKTNKVDIWSLGCVLYRMFAGSPLFNDPFEVWKYAMIPSSSLPVVENLGFSIACENFLHDVLQPNPEDRPSAVECLKKDWIINKSGASRYFIGRDLHTKLSKIQLAAPNVHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6H1</accession>
    <name>A0A2T7A6H1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_164278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6H1"/>
    <dbReference type="OrthoDB" id="10517506at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="18565" checksum="21296DB19C54A246" modified="2018-07-18" version="1">MFLFVFPIFSYLPFSTNFPSPSTFVKSLPLLFYFYSSPPCLSPCYSRHYQLIISLCHRFLHPGLGEHWLHSAKKIILFVAFNRHQSDLNSNSNCGRERCSRDRGRVERSEKKVLLNLNGRATRLQFNLPAERQRMFIKIDVSRNHWPEEVLRKILSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7I5</accession>
    <name>A0A2T7A7I5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7I5"/>
    <dbReference type="STRING" id="42251.A0A2T7A7I5"/>
    <dbReference type="OrthoDB" id="5339076at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="872"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="960"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="984" mass="107634" checksum="69A902E9EC7A3C14" modified="2018-07-18" version="1">MSLAVRGGIPISLFDRRAAPLTPFSDLSDNPDTPGTTYSFQDPPQHKSANMQAEPAHHALPGLLDPHVPTTDDEMMDSDADIRKDSDFDIEIDADEVYSNAGGVDLDVNYRMEEDNADNSHQLYDNDDIMLDEEDDIIFEKQQVDDEADPIPGGVPTSAVPEASPKTLPEEQSAVPEESNITHSIPPAISEQVDQPSLLLEEPNAGETAHLTDSQPTASPAGEPHGALAPPEDAEKAAAVHETITQDSDLQHKENVWSENTSVTLTNDVVPLEERQANETTEQPHQPVTTGNEADEQGVVSLTDEPPSFDPHPVVVQYEQNHVSLFPPPDDVDLPFFIKDVGVCLRGMNELFSELRNVLDGSVSLGDELVIKIVDYGVEISEDSKSSYEFSLQHILDLHVRLSLQDNVENPEALRLVLFSRPSVSSRINMLLSSANEGLGYNKAIEYARRKSGDSDANSEQRFVETSEGGDLQEAEVEDYNNNDDSPAAFAHDTDKPAEVESNLTENQGSISEQKEEFEEEDDDDDGDGDDDDDDFDLEYGNDDIANGGVEGENEGGANLKDGAPNSPSPTTAVSKDSPTSINESPNHGSETPRAQENTVLELETVSNSASPRDTQTPDEVEESVSTVQGDEAHSTEEEEEELIEYEDYETFGESESHHSPHTVNSESAEQNLGDNGPSPYEDPEQQQDAARPSDTPENYEQQSTANFIDPSENAVDGDHNESHSPSDGDVNVNNEPSSIPVFGGDGEGEGDYIGEQQEEYGAYEYEGRQGFEAGQDGVRDYLPVGEQYNIQDPSGDSHESSMQRYSRPEQSDQLADDEQNQYLGETAEYEDGYEHYNAEYDGAVDGQEALPGETEYDVGYQIYDLNQAHLGTDYDDDAATGDANETGLATNAENDEAVGSLHPPELAPEVESLLGYDSDDEAEHNTLSEAKQSTEQKRMYGELEQDEDDDEILGWSKFSNPSTTSSPSSDRTSSRPAKRQRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7R7</accession>
    <name>A0A2T7A7R7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_751197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7R7"/>
    <dbReference type="STRING" id="42251.A0A2T7A7R7"/>
    <dbReference type="OrthoDB" id="10465344at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="9658" checksum="D94498E29CA1898B" modified="2018-07-18" version="1">MATTNLCRKRWLAIRGELTRDKLPTRVFKCVLATTLTVIISLLPNIRNVYGTATYLASITTVFVFGHPGRRLGSMRWYLHHLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Z3</accession>
    <name>A0A2T7A7Z3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1071341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Z3"/>
    <dbReference type="STRING" id="42251.A0A2T7A7Z3"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="112"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="17450" checksum="4681754B29CB7622" modified="2018-07-18" version="1">MGSKASRLLGASSTRKYPTRAPQVTESPSYQAHGPVQASHNKTQDILRDAQDPDYQSMLRRVGVAEILGPARNVAVSEKSSNSLHTISRRQALHDQQQIESSSKQGRDRRTWVDTSTIFEILKLRDEKKWVAERIEKELGLAPGLVHRLGDRVGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A842</accession>
    <name>A0A2T7A842_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_962316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A842"/>
    <dbReference type="STRING" id="42251.A0A2T7A842"/>
    <dbReference type="OrthoDB" id="5321570at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="390" mass="44407" checksum="E6236FDDBE0536ED" modified="2018-07-18" version="1">MGSKQQSSKAFASWNTSSRVPPQPQAPSPPSPLPLPEVLTEATKTEKQLFAAAVFRTPETLASKSCNLKTSSEDFQCRERDLVKALPPRLLQSPSTSGRIANRWACKVHEALDGALLEALFYKIRYEAWGTHLNSLVPVKDKDAQELVANLRIITAYWIPLEDYEKLYMASPPRDDMYQDTDCDGCLLAAIAGDIVCLEAMRIAIYSRKHRGGRLVPWLDAWIRTHGKDALHRIRERSETVGRIIRNARRVSLTTREQQAKKDKREREKSFRDELRYRDRKLKYSDPFSLEAKSYWEDKKPDGPFADSHAIPRRREPGPIDRVDGPDPNPHETTGPGAHSFYGNHFNPFDVYYNSDDDPFPAAESGYTSEYSAVNIPEHHQEIERNGGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Z1</accession>
    <name>A0A2T7A8Z1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1104700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Z1"/>
    <dbReference type="STRING" id="42251.A0A2T7A8Z1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="100"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="706"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="779" mass="86991" checksum="A5368292512D8840" modified="2018-07-18" version="1">MAPKASKTAIAQSSIRGRNSGNNGSNNIYSTITNNFGIQVPSYVPATFWELVANGRWGVSLPEIDLDHLCDEYNLPQADSGKWIFKDVGYREWQESKESKLLWLCGGPGTGKTMLAKRVAAEFLGGSGGSSEGVQLAFHFVSPELPTNGIPADETEPPQPRLAKVASDLLYSILEQDGSLFDGCKAELEKQGEKFFTNPSSLWKVLGKAIEDCHADPVYILIDGVDGFRTSLCGELIRRILRLMEIRTVKVFLSSRDVPHISNNLPHNPAEYIKINLDTNCFVKEDVENFIGRKVNAWGWDDDLRKGAMEALLAKSEGIFLWVSLAIKGLSNLSSGPDFDKFLSKTPSGLQEVYRTMLHTLLSREEAGEVLNMIWSVALALRPLTFSELGHILAFVGEKASAGPQAPHGAKSSEIRPRREEEIRMYVKSSLGFLRATDTTVSIVHHTAKEYLFEEHSKGNLPGVLSQSEADLTVSWGCFLYLHHTFGDPERLPRGDVKRRYLRPQHSSSALDYKQHKPGETPWEMARGNPEEAVAEWPYLRYAAESWYIHARRRIEILKDNFCDDSAHNWLQHQFFETSDTIRNPWIELCGDSRMEVLVGEQSPLHIAVCLGLMPLVEKALSDFTKATNNNWSPLHLAAKFISGAYKILIAKGEQSLLTHSDQDGNTPLHEAAIYGHLSMLKALVKKFAEFERGARSDEVNKKNDLGNTPLHLAIQFDHPDMVEFLVMNGADPNIKNGALVTAFELGERLRRGDSLDILKRARHSEGSGGWWGRLRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9S1</accession>
    <name>A0A2T6Z9S1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1069957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000684">
        <property type="protein sequence ID" value="PUU72186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9S1"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9S1"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl phosphate synthase ATP-binding" evidence="1">
        <location>
            <begin position="60"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA carboxylase BT" evidence="3">
        <location>
            <begin position="300"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA carboxylase central" evidence="2">
        <location>
            <begin position="361"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48118" checksum="F30A2A0A9788D929" modified="2018-07-18" version="1">MRSRLEVREVQIDTEGLVTVSGEIYAKGYTHSAEDALQKALEIGFSVMILALEGGGGKDIQKLARNARNMEVQLLADEYGKNISLVGRDCSVQRRYQKIIDRAEVTVANQTRFSRMEKTAVQLEKLVGHVSAGTVEYNYSQSDDKFYFLELNPCLQFEHPTTEIVTSLSALQEVFIPSLTHSSVTFSPILNELISNKLTTEPPETFLAVVCCTVTKADAARVSDSEMNNFAMKPAITYGKFRPPRILKLLEIVNKDLCCEHISIKDFDSWTIQNSELEENKHIRYEYNSFTERFFIKYIECKASLKRGQVLANDILETEFSVDFIYQGKRYKFTATRSRRSYNIYWKEKEVWATRLSLEILDNLSCVKHATPFNSQLSDFGIVQVVGTKLPLRFTLLTTVLKNIIDGYGNQFIMATSFKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA34</accession>
    <name>A0A2T6ZA34_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1097447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000565">
        <property type="protein sequence ID" value="PUU72350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA34"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA34"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015371175" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="40"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="520" mass="57143" checksum="3FA6889734920EFF" modified="2018-07-18" version="1">MVRIGLKETLFSLLLIGGGSCAVSDNSSLPIVDLGYVKQQATEYNQTYDFYHFRNIRYAAPPLGDLRFRKPQPPLPQAGIQNGDISFVESTCHQTWPPFLGTTPFGEDFGVEDCLYLDVYVPTCVKPGDDVPVLIWVYGGGYIIGAKEISGDPAHLIQSSDEPMIYVSFNYRLGAFGWLSPANVTDIDANIGLHDSLAAMEWVEKYISKFGGNKDKVTVMGESAGGGVILHTITSNGGEGKKLPFQQAIVQSAGFDPKRTHYDNRYAQYNEFRKSTNCTTLECLRDAPTEVLLKANHDVIMLLVTGEIGAFGPAVDGGYVPDIPIRLLTQGRYHHELKSLIASSMGFEASIQFPTPDTVTNGTFDDLLNGLYSLAPESLKQQALALYPYQGPGITEWLRTSAFFGDTVFNCNHVWLAKSFQKSYRYVFNIPPAFHGEDVAYTFYTGPDPAIANETTAIIHQKFITNYVTRGEPGCEKGACLPSYGSGANALSMNLTEIKVVRDPWATERCDLLVDLAGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBI2</accession>
    <name>A0A2T6ZBI2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000458">
        <property type="protein sequence ID" value="PUU72829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBI2"/>
    <dbReference type="OrthoDB" id="5475664at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15541" checksum="96A0744B0BC24E31" modified="2018-07-18" version="1">MEHAEVESGGGIEMPLKRYVSSGNLQAYRRLSDLIGFRRPLKFGLYRLRPFLERPGLAQPMAYRLAYERPGPLGTLYLNVCLSTPPPTKYCDSGGEGNVTSPSSPLQDGTCSPRPLLLCSHPAGFKDIRLSRSHPKDGLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBK0</accession>
    <name>A0A2T6ZBK0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1007676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000454">
        <property type="protein sequence ID" value="PUU72849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBK0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBK0"/>
    <dbReference type="OrthoDB" id="5374542at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="31558" checksum="81BA35A56A86F342" modified="2018-07-18" version="1">MPDDKLNGKKRDVKNSPDEENSEKDGKENKKKSAASPSLSPHPEKHHTTPLSSKTITTPKSLLKKSNDKTPTPRTKTVTFADDAKSTDGDSIANTVRFPVGLGIGGRGDIPRLPGSPQPHPALLAQQSSSSSSSTTITQQGTFSPPLNPAEDYHSQQQNTRPQIAYLLNYYQARSSWKFSKTKQNWIIRNIWNLAEFGAEVLQSALWAYVNGLVAQGPKGRLLAEAKEVAKARREELGAVDAEDDPKYRRAKLVLTALGDDDIPSEDEPDDADGMDMDSDESVYAEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBS3</accession>
    <name>A0A2T6ZBS3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000440">
        <property type="protein sequence ID" value="PUU72941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBS3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBS3"/>
    <dbReference type="OrthoDB" id="5409589at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="298" mass="33178" checksum="243411C186085600" modified="2018-07-18" version="1" fragment="single">MASLLPSSGRPSLTPLSMFYPRRTSSSENPYVPSTSSPLSPHSSSLPPLETSAATTNSHYYRPLSSSTHSPARASRQFRVQSLLATDPLLCHLTPATIIRLSTSGDFDFEPGEKEWSLRAAEGTVKVNEWLREVEGWNREWRRAYRESKDTGDGYLPPADRPEKRRKTDMGSIREEEEGAMLDGSKPVRRRLFSEDNGTGGSWGVIAKDDTPEVGAMEAPKPQTDSPSLRRGGKPLTPYQLKMQRQRAAEGENGGRSEPDQILVKPVEKIGAKEEREEEEGDEEDDELEEGVEYWGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC15</accession>
    <name>A0A2T6ZC15_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1197186</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000423">
        <property type="protein sequence ID" value="PUU73035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC15"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC15"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="321"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU73035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="694" mass="76839" checksum="4B8FA6B54F2B2742" modified="2018-07-18" version="1">MSHSMHGSGGGELFPIPGDPYFAKIYWMFVGGAIGVGVLVHLGELLLYRQRLVDALISAASRALPEPARPKNFLVRWYATLTATAREAIYYTAPLIDAGRIPSSAGSRASWKKALPLNLPQLGCVLLIAANLSLLLSLVFYGWDVENRWNWEALAVHTGWITLAQLPLVFLLAGKRNLIGYATGTSYERLNWIHRWVARCMFITATIHLSYFLRTWAQYDYIERKFEIDIISRRGLCAWCVLLWIVLSSFAPIRGWRYELFVIQHVISFIAFVVMVRLHTPSNAHIYVWVPVAIFFLDRALRIIYMLYTNLAIFHPGRLGKPSRPFTCNATFHALSDKATKVVILDPPFGWRPGQHAFVSCHSLVPLQSHPFTITTLPSDNSLEFVIRTQKGGTGKLFDYACVLPVNKDKSKTVIIDGPYGQVRPLEQFDTVFLLAGGAGSTFIIPLLRDLVRLKRESKPMVTRKVRLVWVVRSSTQISWFAKEIADAMATLGRLDGLVLETSVYVTCGVLSALSSSSPSKNGLIDGEDSRAMYAEKAQGAAVEESELCGGDRCCCQEVLEDEDAIIEANKADGEKKQVCCCCSQSTVPHPKIPKTTTNTDLVGAQTQDSTSENSFAASLYLPPTHVFSGRPAIKALLNKELEKALGESAVVACGPAELIQKTRQVVVALSDERAVHKGTGAQGIYLHTESFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCN3</accession>
    <name>A0A2T6ZCN3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1095667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000407">
        <property type="protein sequence ID" value="PUU73174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCN3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCN3"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="477" mass="52653" checksum="BD6B7EAD95C9E748" modified="2018-07-18" version="1">MVGILTVSNSTFASSLPSGAVSYIRKDLDVSSPEITSLTISIFLIGYVVGPIFFAPVSEFYGRRWVSIIAFFWYTVMSIGCALAPDIGALLAFRFLTGIGASAPLSVTGGQLADIWDDPVKRGRLVAVFCACTMVGPTLAPFISGYISETQLGWRMTFWIGFIIAAISFIPLIFFCPETYAPILLLRRAEKIRAEGDMHAVAPLELDDRSLKKIFTTTLTRPFRMFWQESIVFFTSMFLSLLYGTFYLSFQSFPMIYQGIYGFTPGTAGLFFLPLAVGGGLACVGGAAWDSYCYRKQKQSPNVPLSPEFRRLPIGLVGGLAYCTGLFWQAWTARAGVHYIVPALSGIPFGFGFCIIFLAFLNYLTDAYGIYAASAMAAASMCRSLLGAAFPLFSRTMYDRLTIPWASSLLAFAALGMSFIPILFIRYGDKIRARSKFCQILLERKRIQLEEEQAREASRAASRAPSFKELALEKEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCT4</accession>
    <name>A0A2T6ZCT4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1005393</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000395">
        <property type="protein sequence ID" value="PUU73256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCT4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCT4"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="83"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="587" mass="63259" checksum="B6838AA8C01D8D13" modified="2018-07-18" version="1">MCQNAAGYNKPKSQVHSDSMRIRNVVEGFIAEQSNRHVKKEDETAQANHGRQVSGRNAKNDLAALQQAQNEIIDELLTFTDEKGESVAHFFVNLPSKKLHGEYFRVIKQPISLNLIKKRIALGEYPTWAEFESAVHLIRTNAEEYNDEQSSIVEDVRKLDAQFHKLLGEAKAKVGNTGGGGSGIRLRLNVHQAQSPPQEPAPTPRGPRIKLNIGSRRESAVDSPSVASRSSPPPSQRAPRVPKKPPVNGLRATRAAPVDGPSPSLESPVTAQTNGARPVRGRSNDSPSKPPQGSKKEPTPPTPVTSLPPLAAPRDQKDLLVLPASQSPRPGAGSMTPSTQSGRSRSPANDSITLRARSTPRTPQPQASSPAPNLAMPPPPQRHSATPVPNGHSPVPQLNASTSAPPALPQPKPNAGPEEPRYRPDGKDASTAIISSVRLAAALNGIDSKFSQELLPDDRKLMTQFSIHLPPEAVAVVFTPVLSTANLHNRAYKLTVELRVNNTTPKLLNPNPSLQKKKEEPPYEFRPNPGSVSTLECTLVTTAQRPTVNGTSNGVNGTTNGTVNGANGAFGNWEMERFRIFFSFLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD69</accession>
    <name>A0A2T6ZD69_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000379">
        <property type="protein sequence ID" value="PUU73396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD69"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="27574" checksum="0763D2687AD81E3F" modified="2018-07-18" version="1">MVIQKFRTDIWAALFKFAEPEWKDNTTLKREQALSGVLPLDYENVIGYAPSRFTRIKYSNKHKLTLQERWEILFYSNDKWDQQDLRKSWKEKPFRLFFQKCYDTIATTCDLATARSWEYLLLQTQFARSNFLLPSPSKYSFLQKYSKRGQLSKIYWVLIQHNSWEISSEIRTLPDKDSLADRWHMWSIDYTSPIPTQYQSPGSLFMEHLKPFHVLQRLEHRWVKTKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDD9</accession>
    <name>A0A2T6ZDD9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1135054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000371">
        <property type="protein sequence ID" value="PUU73502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDD9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDD9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF4">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="334" mass="36543" checksum="2C2D39A2798312C7" modified="2018-07-18" version="1">MASQGTVLITGANGTLATALVENLLINHPENPLLLAVRNTSDSDAHTKNLRRLSSRHPSTPVRIEPLDLSSLASVRTFTTTVMSLISSGAIPPLAAIVCNAFSWSLNSGIQFTKDGYESTFQVCHLGHFLLVLRLLASMEKAGRVIIIGSEEHSDEKPSLISPYRPGIPEKVEELVKPAPEDAKTTFHRGFTRYATAKLCQTMFMYDLGRRLSEDPKLSGITVSVLDPGGMPASRCFTEHPTVVKLLMNYVFAPAVYLLKYVTSKFRTPWDASTDVMDVAVGDLGKVSGYYVCKSKTDGSCASRDEILQGVLWRKSVEWTRLEKGETVLGSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDH5</accession>
    <name>A0A2T6ZDH5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_540016</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDH5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDH5"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="322" mass="34426" checksum="C9108ED55A0E7189" modified="2018-07-18" version="1">MIDNSPPPPFPLPTPDPDSKRHATSAASLDFGCTNNSLEWKYVLIKWTSFACAIVNCLCAGSILLFSLWAPTFQQKLGFSQMQVNAISIAGELGMYLPVPIFGYICDTYGPAKLSLLSSAFFCPAYLLAAHAFANQLPFPVMVLAFVFVGMGTSSMYFAGVTTSAKNFTGNRGLALSLPIAAFGLSSLWQSQLVSRVFTNEATGELAIAAIFRAYSVFLVVIGILGALGLKVIKSDGEISRTGERDNLLEGGQSSGSPSYGTIGRGVVGEEVTEKRPLINNATREFLGDNTMWFFAAGVFLVTGPGEAFINNASFFFSFLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE55</accession>
    <name>A0A2T6ZE55_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_509324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE55"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE55"/>
    <dbReference type="OrthoDB" id="18530at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40368:SF1">
        <property type="entry name" value="YALI0F14399P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015434059" evidence="2">
        <location>
            <begin position="25"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="260" mass="28876" checksum="9C986265536A8146" modified="2018-07-18" version="1">MRLPHNNSGIAALLLSLFISSSNAYEKPGTGDPEPLKYTSGDQIYVQCLNRTIDTGEHVQDEKTGILQYIPFATCNETGRPLEVKFLEDGEVNCTISFLSDEMFHLFEFYVHHDSPLACRVPVRPLGGERDLEKKNEEEYAPLVFALAGKLEASHMHLATNMNVLFHLTSPTSGVIDSGAAYSTSPTSSDLTRIIIGDPLPLRLKVHWFRTLSPLSTKSNGEHVTVHLLGYCLLSAFAGACCVYTFLVGWEFPKRLKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEB9</accession>
    <name>A0A2T6ZEB9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_505444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000340">
        <property type="protein sequence ID" value="PUU73840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEB9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="152" mass="16981" checksum="02701E9CC3FC3190" modified="2018-07-18" version="1">MDPPGRKLGLSKVHPFTPPHFLANIPARIPQVSTRFCQIRGELKVCQPPAVPHPSVRTHCEGRVEKVNQPDSTRKGGNGREEGRGSENLLSPASFPEQREQSRAFIGFQHATHLITNRTVSQKALAKVQVSYYKGVSKQVPHRTPLQKLHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEG8</accession>
    <name>A0A2T6ZEG8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000340">
        <property type="protein sequence ID" value="PUU73836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEG8"/>
    <dbReference type="OrthoDB" id="5309447at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46153" checksum="1107316CBE78C830" modified="2018-07-18" version="1">MLKSKPTAPLRRTADNSNPPAFGGNEISPPRPPFVKRHSSVPSSESLGRKIQRHLDAGNPLYIGFDPADPPRDSTLVAGPARGGDTGGCAGEEEHTTARGRKGWSRKAVKVLSCGVPLDVCARIILTTGMMVAILSLLWSVNRLIQLKGITDPDSLSFTSYLIVYQCCWGTFFGAICFFGFILMWGKWRRSPTAALFFTVTWILVTILMLVTSVLWFYFYFFFGHKRFRKCHEKVTSAGPAFGLDAPIRQATQDQIDGCLLRARKQGGGVLFWGVVYIVMFYAGIIIAVWGRDYRRRLLEIRKCEERAKGPGAEGEKVGLLLGTAPLGRLVHSRRMTIGPTRSELEGSLAEEESSPKDTIVRLSGTIRVGQVVPTSSSSREQHRDRKGSNSSAESLGLGISVEGQSFAGSSSQGRSMAYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZER3</accession>
    <name>A0A2T6ZER3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000329">
        <property type="protein sequence ID" value="PUU73990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZER3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZER3"/>
    <dbReference type="OrthoDB" id="15893at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039196">
        <property type="entry name" value="Fmc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28015:SF1">
        <property type="entry name" value="ATP SYNTHASE ASSEMBLY FACTOR FMC1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9657" checksum="AB747D24445D95DD" modified="2018-07-18" version="1">MATAAATATTTTTIKTLYRTLLRELPPISQKRTYLHTLSKYLRAQRTYATLLERYNPSLGLREDDDDDNRVRMSARRVGLDIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF61</accession>
    <name>A0A2T6ZF61_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PQ loop repeat-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_480048</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF61"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="277" mass="30442" checksum="8D45D0B67475ACDA" modified="2018-07-18" version="1">MPAQESIPPAANVLGTIGTVLWCVQLIPQIWYNYKNKSTEGLPAIMMLVWGFAGVPFGAYAVIQLTQSFTKNLNIPIQIQPQCFASLSLISWAQCLHYSSGWAIWSSSLLALGVAAACAGAEVALILTLRPIYDRGIEWPMLIVGITASILLAAGLIPPYFEIWKRRGRVVGIDFVFLSIDWFGALFSIMSLVAQHTFDYLGGVLYLVVILLESGIFISHWVWLFRTRKQRKAEKEADATVAAATAVTSPALVDERSCDIASTTESSNKEVELKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG00</accession>
    <name>A0A2T6ZG00_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000300">
        <property type="protein sequence ID" value="PUU74431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG00"/>
    <dbReference type="OrthoDB" id="5284003at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59599" checksum="47F004D85AC96DF9" modified="2018-07-18" version="1">MKLCNIPVVILHEILDHVSTPVDLSNLTLTSKWLGNLAAPRLYRRLEFTLSSTTQTRKFCECLLMEDRRQDWRHWTRSMHVSDEVREGSSRRRSPTGIWSGLAGVLDGLAGCGLDEFEWDSRDVPPRIIVKSLLGLRSLRSLKLEMPLRSRDHAFLEELAVAHAAYLRSMHIWGIQNDGQMNRVGKTVGFAGELKDLSLCVAADCDWEDDEDEDEDEEYSSSSEAGGEREVGSEERNKWMTLPTDVHNTLSSIELNGLFNLRDSPHFFNPTTLRRLELRQCTGYNSLLRALSSHPDIRNMEEVVLGSWENCDIARVSEFIYSCPKLKILLLSLSSYALTNDLMRSIIPAVETSRATLEVLLLDFRHQSRIGSTRDNNNNSSNNNTCVDKTLYQNPRWLSSIKTFPRIRELGVSIDLADLTSLPEISTILPPDIRVLDLRFPWQTVERDRALRTAQIQSLVDASPDTLRLKLVILGDGDDYDVCTSYEVARDAEAAGTAVVAPANGPRGSMVAGCDHKLYRLRGDCFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG27</accession>
    <name>A0A2T6ZG27_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B9Z19DRAFT_1000538</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="NESQ01000298">
        <property type="protein sequence ID" value="PUU74450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG27"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG27"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
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    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
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    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
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    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
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    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="843"/>
            <end position="865"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="886"/>
            <end position="910"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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            <begin position="922"/>
            <end position="939"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
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            <begin position="951"/>
            <end position="971"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="991"/>
            <end position="1009"/>
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    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
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        <location>
            <begin position="772"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1082"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="20">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="440"/>
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            <position position="440"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="440"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <name>ATP</name>
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            <name>ATP</name>
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            <name>Mg(2+)</name>
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        <location>
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            <name>ATP</name>
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        <location>
            <position position="514"/>
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            <name>ATP</name>
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        <location>
            <position position="547"/>
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            <name>ATP</name>
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            <name>ATP</name>
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        <location>
            <position position="628"/>
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            <name>ATP</name>
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            <name>ATP</name>
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    <sequence length="1104" mass="124096" checksum="1E6BCB22CFA8473B" modified="2018-07-18" version="1">MGPEYSEMDLPLTEARPKGTAGGDAGGASGGQKSKERRSSGSKFKFGFGRRKVDPSTLGPRVIHLNNPRANAVGKYVDNHISTAKYNIATFIPKFLYEQFSKYANLFFLFTAALQQIPNISPTNKYTTIGPLIVVLLVSAGKELVEDWKRKTQDQELNRSKARVLVGTSFETQRWINVRVGDIVRVESEEPFPADLVLMASSEPEGLCYIETANLDGETNLKIKQAIPETANLVSPSELSRLSGRIRSEQPNSSLYTYEATLTIGVGGGEKELPLSPDQLLLRGATLRNTPWVHGVVVFTGHETKLMRNATATPIKRTAVERQLNVDIIMLVGILLLLSLVSSIGDVIKQATASSTMSYLYLGNNNKVRQFFADILTYWVLYSNLVPISLFVTVEIVKYSHAFLINSDLDIYYPDTDTPAVCRTSSLVEELGQIEYIFSDKTGTLTCNMMEFRQCSIAVMHHFLTLLATCHTVIPERKDNNPNEIKYQAASPDEGALVEGAVQLGYRFLARKPKSADTVIMERLSRDNPMVEATLQHLEDYATEGLRTLCLAMREIPDEEYRQWSAIYDKAATTINNRGEELDKAAELIEKELYLLGATAIEDRLQDGVPDTIHTLQTAGIKVWVLTGDRQETAINIGMSCKLISEDMNLVIVNEDDMESTRNDLSKKLAAIKAQKSSGAEPEALALIIDGRSLTFALERDLEKTFLDLAVLCKAVICCRVSPLQKALVVKLVKRHLKAILLAIGDGANDVSMIQAAHVGVGISGVEGLQAARSADVAIGQFRFLRKLLLVHGAWSYQRISKVILYSFYKNITLYMTQFWFSFQNGFSGQVIYESWTLSFYNVFFTVLPPLVMGVFDQFISARLLDRYPQLYQLSQKGLFFKQTSFWAWLVNGFYHSLVLYIVSELIFLFDHPQADGKPAGHWLWGTALYTAVLATVLGKAALVTNMWTKYAVMAIPGSMLIWMGFMPAYATVAPMLGFSEEYHGILGRLITSPVFWAMVVILPCLCLIRDFAWKYAKRMYFPQTYHHIQEIQKYNIQDYRPRMEQFQKAIRKVRQVQRMRKQRGYAFSQADEGQSRLLQAYDTTKERGKYGEMKSVRSDTRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG66</accession>
    <name>A0A2T6ZG66_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_443501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG66"/>
    <dbReference type="OrthoDB" id="4078573at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF40">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="565"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="78364" checksum="17ACD861B58AE417" modified="2018-07-18" version="1">MKEHQIVRTVGNPAGYVSVVYALILLTSRQSNLLWFRYHTNGRVASIAPSPKYNRYADIAASTVHFQDESRDIASEYAGGISRYAAFARVTPPKPTRNSPPTPRQTATVTTVTSAPTSHPTLPPILPLLPTPMHTGEPINNFEEVKPHHRQGYHAYAPPLPPPPPPPSSTMNSDHTMSPPPPPKEVRNYLNNTEETLFMQVFVEEVGIWMDSMDPYKHFSRLLPFSSLNEPMLLNAFLACGARHLTLVNPAYHEDKALNYYDTATRLLLASLQNPNRDTEMCATTAVILNVYEIMSERALQRMNHIAGARALLKECRWSARTGGVGGACFWLNVSMELLSCLHFNWAVAWEPDEWGVDMDFNRYCEPGREELWAYRIIYVLAKIANFRAAFPRQQQEAKTVTQQMYLNNETQKRYEEWKRLRDLCMAWNDHIPRSMHPMAYLHSYQTTTKSAFPEVWLVKRCAIVARLFYHTAMVLLAQMNPFMPRESDEMRDMEMTNSHLICGIAAHVKDRGVASVALRSLAIAAECLTVRREQEEVLEIFTKIKKETGWRVNFVYKELKEKWGWEAPDPPPQPSSLLQSSTMMHQSPTPSNQYAQYQRQHQQQQQHHHQQHQQHQQHQQQQQQHHQQQAQQQQQQPQVRRLPQLVNPLMAVSDYTSNSHPYHPHYVSAPPQVERHHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH62</accession>
    <name>A0A2T6ZH62_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_997909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000269">
        <property type="protein sequence ID" value="PUU74838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH62"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH62"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="340"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="694" mass="76838" checksum="C41B4B517A64C60E" modified="2018-07-18" version="1">MASPPPPPTKRAKLDVPSHKASTQKELELAVGIAGYVHPDLPGWQGVFKKRYADFLVNEIGLDEKVAHLTDFGSEFLRKGGKKREEKKEQKEGAEAEASVSSVVGEDIGPEVLAATLRAQLRLTSQQNPKLQGIIRLTEHITQSVDREERGLVHTAIREFSSGKIDSVTLSGDQDGCIRIYASTGQPGMRQRKRGNRAGRRRNKSDKGDGEVGLDYCHFLVYKVNRDTMDVMGILPHLIGGTGGKNPFSFAGNKDKRAVTVSWFSAYKVRAERLARLNQGEGGLRGCHVGNFCYKDTGLGLGDLCGNEFVITLRECVSSDASKSLEEVVGAAMQRVRETGFINYFGLQRFGSHGVGTWEVGVEMLKSNWRGAVEKILSYDAAILEKDDDSVSAEEKSRARACHAFLTTYDFQKAVELIPRRSNAERAILTSFRDRGIEANEHGGRLDYMAALQAIPRKMRTIYLHAFQSFVWNYVVTERIAWGIKVLPGDLVMAEPTTAAESKAPKPITTDDTPEIDQDGEVIVRAPPGVAGTNPGEEKFKRARALSKEEAESGKFTIKDIVLPTPGWDVVYPQNALMEVYNRVMKEHGLDPLNMKRTHRETSLPGSYRHVIGTFINGEASYEIRKYRGDEQIVKTDLEAIKQREAVAEGAAKDDRKTAVVLRFQLGTSTYATMALRELMKDGVKAFVPEFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHC1</accession>
    <name>A0A2T6ZHC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHC1"/>
    <dbReference type="OrthoDB" id="3533623at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="350" mass="39260" checksum="A0C0B101A981904C" modified="2018-07-18" version="1">MSFGHDSILSRGSSGSREGLAMNWVLDHVLAYPATYDFALPLRTIYTLNSTTPHTSPADFKLLLLEHISNLPSQPCTLPPSFLCTFIRKCFPRDLENVQFDQALTALDYIRDLEIRRSKELEKAARARGEGDRRIVNLRIKSIRTEQFYARAIAGIRRWTLLHELSITPFNKFNCIAILNTLYPIEESDVNSYLPAPTLASQRHALWRYITGVEKNGPGILESVRTSNGGWTGVSEAVNAYLRLSLDMIQKADELARPSSIGSFQSDDSMDMSATLIARSTPERKRKKSGFLRRDTAGSEASEEEDGKASTLERIVRGLARLGSSQHPGPPKKLYESDTGSEEDFPMRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI11</accession>
    <name>A0A2T6ZI11_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1091150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000251">
        <property type="protein sequence ID" value="PUU75096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI11"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="54" mass="5915" checksum="E02017B867C4E49B" modified="2018-07-18" version="1">MIPMTPSCPTGSAVQHGQHCHPPLRQPRSEPPHSAPQTNPLRLLAPPRLFTLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIG4</accession>
    <name>A0A2T6ZIG4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="14">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1090759</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="14"/>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIG4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIG4"/>
    <dbReference type="OrthoDB" id="2748310at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 14" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="877"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 1 C-terminal" evidence="16">
        <location>
            <begin position="444"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="788"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="985" mass="110190" checksum="18EBA8F8375DBF7B" modified="2018-07-18" version="1">MARLGRLGFLGLAVLFHLIYIYSIFDIYFVSPIVHGMQQYRVDAPAPAKRLFLIVGDGLRADKCFQSHDDPDYPSENRYLAPFIRSKVLNDATFGVSHTRVPTESRPGHVALIAGLYEDVSAVTTGWKLNPVNFDSVFNESRHTWSWGSPDILPMFKHGANDESRVDAFSYDEEMEDFTADSIDLDIWVFDRVRELFESAAHNDSLNAMLRQDKVVFFLHLLGLDTAGHSYRPYSAEYLRNIKVVDEGVQQIHKLVNDFYGNDDKTAWIFTADHGMSDWGSHGDGHPDNTRTPLVAWGAGIKKPVASKVLEVTGHEDGFSGDWGLGAVRRVDVAQADVAALMAYLVGLNFPVNSVGELPLEYLDANASVKAEASLANARQILEMYKVKEEQKKSTTLRYTAFVPLSEGEQSLESRFVEIRGLIDNGSHERAIEKCVELIKVGLEGLRYLQTYDWLFLRSLVTAGYLGWIAFSLTTVIDLHVLHGRTEPTRTRWSSIFFISGLVAIYSILMIQKSSWTYYAYAFFPAMFWEEVYARKNSTAEGIRRLVAHLDTWSAYMGLGAKMVGFLVLLEAMVYGYFRREVFTGCFLLATIWPLLYGPGFLRKNKLLAASWMVCCSLMSTFTLLPAIKQESENLILLGGFFMFSLGLLYMMFGETIVNGGDGAQVARSQDWVSKSILGLQLGLIGLSMFVTRSSVRSLQAKLGLPLGNQAVGWLVLVFSIACPFLHGIRPQSHYFHRLVVIFLTFSPIFVILTISYEGLFYVMFCLTLVAWVRLEHKIHLHSYRKLPKSPRSREGEMKDASSGPDETLKKNSTASTAGPHAPCPQAWRELTLADARIALFFFFLIQVAFFGTGNVASVSSFSLDSVYRLIPMFNPFAMGALLVLKLMIPFAVISANLGILNRRIGVAPSSLFMIVMAISDVLTLNFFYMVRDEGSWLDIGTTISHFCISSMLGVFVSALEFVSEVFVGGLEWRTGTPCPPPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ66</accession>
    <name>A0A2T6ZJ66_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1090117</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000226">
        <property type="protein sequence ID" value="PUU75538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ66"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="500"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="646" mass="71314" checksum="B5E506AAA4221B92" modified="2018-07-18" version="1">MSDKDSAGEGSSSLSKRKRTISDTPLPRPSPAATPKDAGDTSSDEDIGPSLPPAGGLKKKKKRRALPHEKLYLSAMPSSPRYSKSLMHRENLSFVTMTPFTDFLITTSADGVVKFWKKVAIGIEFVKMFRAHTAEIVSVTVSSDGRCFATAGADNRVAVFDVDTFDLLTTLTLPNTPRAVCWVHKRGSSLPLLAVSDTETTAISIYDGRPESMKVLATLPKLHRAIVHLMSFNNKYDTVVSCDEGGMIEYWSPHSEREFEKPSSVFVYKSDTNLLDFKRAKSVPSSLTISPTCEQFATFSYPDRQVRVFDFSSAKLYRSYDESISTLTTIQQAASADKKLPDLEFGRRIAIETDLTSLPSLTKQNIIFDESGYFIIYGSLAGIKILNMTTNSLPRLLSAEEGIRPMHLAIYQGAPKKKALMTVEMAASANPLLNESTERDPMIVCTAYQKPRFYIFTNDPSASKSERDILNEKPTQVSQASAGPTAATAKHESGQAAIIHTSLGDIHVRLFPEAAPKTVENFVTHARNQYYNGTIFHRVIKKFMIQGGDPLGDGTGGESIWGGEFEDEFSTLKHDKPYTLSMANAGPNTNGSQFFITTEKTPWLDNRHAIFGRATQGLDVVHKIENVRTFKEKPEDDVKIVSITVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJT6</accession>
    <name>A0A2T6ZJT6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1089621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJT6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJT6"/>
    <dbReference type="OrthoDB" id="24683at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU75751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="14143" checksum="38240AD5240879F5" modified="2018-07-18" version="1">MGAIRRSKTKRRTRDMDQVHSDLRDPKQLAQLKALVPDEDKPGLGKFHCVECAKYFESEWNMVQHRRGKNHKRRVRLLKEEPYSQKEADAAAGIGTAAFYQASEDKKEQEKIGQRLSSMELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK32</accession>
    <name>A0A2T6ZK32_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase delta, subunit 4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1089471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK32"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK32"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="9956" checksum="6172FDD05F351EAA" modified="2018-07-18" version="1">MGCSPAHQQYLCMQEKILRNFDMQAKYGPCIGPTRLERWKCAEAFGLNPPVEVLAIILAEELRDGIGVGSDSGRDSRRAYLESLLDIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK54</accession>
    <name>A0A2T6ZK54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_306545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK54"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="17791" checksum="75D1B5D2C6EBBF90" modified="2018-07-18" version="1">MEEKIDIHPAQLSLLCPKGMVFLSWPTFNFSFINQIGNWESKETLPVLWIALFFFLSFLPRSSIQSEGAPLVCILDKQPSIFAVVGLALFSLHGCPGCPLAICLPCLHAVRSLFYLLRVRFMYDVYVWQKCGATVKKKKEKKDCTAGVWPSFLSELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKB0</accession>
    <name>A0A2T6ZKB0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1102668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKB0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKB0"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="260"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="472" mass="51958" checksum="D1F9791BB5466254" modified="2018-07-18" version="1">MSTRPQNVGIKAIEIYFPSQCVDQAELEKFDGVSTGKYTIGLGQTKMSFCDDREDIYSLSLTVVKSLLEKYDIDPMSIGRLEVGTETLLDKSKSVKSVLMQLFTPNTNIEGVDTVNACYGGTNALFNAINWVESSAWDGRNAIVVAGDIALYSKGNARPTGGAGCVAMLVGPDAPLVLEPGKRGSYMSHAYDFYKPDFTSEYPVVDGYFSIRCYTEAVDGCYKAYNNREATLAALAHKNEGANGNGVTNGNGIASRNGHAASNGGIDRFDYMLFHAPTCKLVSKSYARLLYNDFLASPTASQFDSVPQDLRELDYEQSLSDRNIEKAFMGLSKRKFEERVKPSLLAPTQCGNMYTASVYSGLVSLLSNVDSDTLQGKRIALFSYGSGLASSLFSLTIKGSTKELAEKVNLKERLEARRVVEPQVYDDMCELRHQAHGKKNFVPQGSAETISKGAYYCLKVDELFRREYQRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL91</accession>
    <name>A0A2T6ZL91_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-l-rhamnosidase c protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1088604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL91"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL91"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43101" checksum="73D78C300647DE17" modified="2018-07-18" version="1">MASPFEAPSPTTPAAVDSATAAPIRRTRTASITQSILDANPHYGVLAAAGEAFAHAPSLKDLRKSSIGSGNSRGRRGSSVSGAASPRTETGLRALAIDEEEAGRKSREILAVGSTKDGAETKKEDGLSAEDLTQDGDGQEDVTHGWWQTALNGLKAFWKFFTTPLGFFLTIYMLNVVAWGGMLFLLLCNAAPAMCVPNCNDINSPRRKWIEIDSQILNALFCVTGFGLVPWRFRDLYFLLRWRLFSDKKALHKLEVIHGGWFRGPSGVNVAHTTTGQVAPMTKSWKMDYVVWLYVWNTFFQCALSGFMWGMNRYNRPSWSTGLFVALACIVAGMAGGQVWWETKQVKKIEGARIVETVEIEGGKREKVKNKGRKFWAREERNVVVLNMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLB6</accession>
    <name>A0A2T6ZLB6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1088554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLB6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="13432" checksum="5680EBDC1F763989" modified="2018-07-18" version="1">MIPTYPTYHPYRTIQYHKHHTPNPPIRHPSIHPSVRPPIHYTSKHHHLQSKLPRTGPSNCFPSSLFLSPCRTCFLSYFILFYFPPFPSPSSSPQKSRVSKWYNNLYHEVYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLH9</accession>
    <name>A0A2T6ZLH9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1088416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLH9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="12726" checksum="EB3A11078017EE6C" modified="2018-07-18" version="1">MLFFFSVCCDRRRGITDMFFMLLVLASIVLYLPNERRVVDTDTGYVLVLYHTVAIMRYSVAIMRHSTVQCPYMRILCEQLTFPSQSSKVAPTDTVLPVVVVEHYDSLAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM87</accession>
    <name>A0A2T6ZM87_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000182">
        <property type="protein sequence ID" value="PUU76593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM87"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM87"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="184"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="500" mass="56284" checksum="58B950A45689DB32" modified="2018-07-18" version="1">MAVVGLTFRALSTLDICLRVGPVLRERYEDVQDTSRDLVDLNIRVENVWIRIEYQLNGVLRSEEEVPQVLCDHREGLLDQLLVLLHTAFKNIDKATEKNGKRKVLKFVLFTKGSLDKDVSALEKWRDTFGSTLHMPSIPRTPRFSRRVMEAKPRSDTSPIGSAIVDANEPTEQLPSFWLDSFRMYSLDPIGYSGAHIVFDDNTHTKYIMETIIVDQGLRDYSELDQEVEFLAEVLGEPKDLPGILTCKGVVRKVGTDGQLEEFQFILEMPHGLGDTPSCLRSVLHRSTHEPPPREDRVLLARQIANAVISVNNLYFIHGDMRPETVLIFPNPGSTLGVPFLVGLMFRSAVGISFRAGDYSWSKSLYRHPSSQGTHPNNIYRMQYDIYSLGVILLEIGLWSPFVDHNGQPGVALSQIVPILKDGDQSQGNAQIKKIFITMAQSDLPQIMGAKYADMVVACLTCLDRESELGSEIEFPEDDGILVGVRYVQRILRVLEEIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMJ1</accession>
    <name>A0A2T6ZMJ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_989368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMJ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMJ1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="233" mass="25905" checksum="1A04F2D11CD69124" modified="2018-07-18" version="1">MAHSEDKKTALHKAVWYEHLGVLRVLLDKGANIHARATHGYTVLHFVAIGTRNSSEAIARFLLDRGADPDVQNEHKVTPLHLVVQQTSANLVAIAKLFLEKGAKRNPRNGSGDTPLHHATRFGRKEMVKLLLDSGADINALDYFGDTALHIAIERHNEPCAKILLAYGADPYVKSCSGNTVWDWVHSGAMWESQEDVIMAERLAKMMGKMCFGKGSQGRRCERERERRSITAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMJ6</accession>
    <name>A0A2T6ZMJ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endosomal peripheral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_989423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZMJ6"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="6">
        <location>
            <begin position="201"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="769"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU76718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1715" mass="187954" checksum="134B134FEAFB11C6" modified="2018-07-18" version="1">MTAQFLTNELTNLVQEAKRKNSDLRHAAEKSLADLKSIGLATDVAVAASELSGRPQFLHPFLIACSTRNAKFSTIGVVCLQRLIVSQGLAKTKLKEVLEAFREAATLGVEIQLKILQALPPLLQNYAEDLKGNLLSEALLICSILQGSKMGVVNNTAAATLSQIVISIFDKVVTEDERVLEVPTVGEGPSESGTIPLRAAAFDAYRVFFDICLLTEGQRPRFLRFSVLPQPFGLELIESVLTNHPDIFLTHPEQAYVLKTRVAPLIMRSLSDRLNFPTTVRITRVLYILLRRHLSILSEECEVALSLLTHMLDPEASASWKRALCMEVFRGICAEPSLVRKIFAEYDTREGKMPIMKDLMGALTRLATENRSVIGSGTQSSAPVGQVVPKDSSSEQAALEAGGVAGIIGGAVGLSEVNVTGLSTQWSLMRVPCIDQLDKSEPPATPESYIYCLTLICINSFCEGLAKFILPLSVTNDATKGAKRRNPTRVASVGMMRTNMRTPSPTKGSLRRKPTMRQHRIPTNPLSMEGHPLYNEIVISAAIMESCWPAVLAACSTFLYATLDNEFYHGLVRSFQKFTHVAGLLRLTTPRDAFLTTLGKAAVPSNVLSANITAAPIAPDSQGLFSNAKGLLSVDSLNNSERLTPGGTEHHPPSLNSRNLLCLRALLNLGISLGPTLEKSWTIVLETLQQADYVLFASSRKTGRQISLNASTARSDPQKGVDAGNPLANIGPELSAVETAAMKMFEGTRDFPDEAFVAVLLALCKLSDGDGEANSRTSIDKSSSPQRSPRSPTFSHKRLPSVSNFSTSQVIGDNAFALAKLGELAQINMSRLIGPNPSSTGWDMLVNHLATVASARDRGNSIRMKAAEVLNEVVVSAAKAIITESTENVAEVQKRILSALREGVTDSEVSGVPDSVTRATELEIHRAGLEALNAILEHSGQSLIAGWEIVFDIIMSVFDSTMIWRRDATILEASAKITKSTRSPKLIRSSFSSLELICSDFLASLPTPCILVLIDALFAFCGQKDDLNISLTTITFFWNVSDFLQTKGESSLSGEFVSSKAQSEKDLLDMVELTDADSHPALWMLLLLRLTGVSKDQRAEVRNGSVQTLFRIFDTYGNQLGPQAWSSCLKIVVFKMMNITQTDEKASDIPKVRTAERKQWDDTINLVLNGIGTLYSNYFEVFVKQSEFRNTWSVFIRYLETLLERQSFEVNTTVFMVLKHVLEKVDKPDNLDSPSTEDVWKMWSGQGVKLVEGNMETSRAGIQETLSAYVDSFKPLYRLLEPTINTDMVDKTLTLLWECIIFPDAPAYFQDIDILTPLQATILEVIQMMRTDIPGVPSLVLKKVADLSTVAYRPPHTPQSTKVRVPSYIALAAQSMKILETVSFRHVESSEIYTTGALSSVLSALKLPISLKYDFARAASSAAAKRPSQWIPATKVVLSIITKALPAIDKLNINEAHQKEVWKLIVEIIGSVVSANTTDIGEATLTSDETFDISSFQEFRSLIIPPLGRAVVPDEVVEAYVKSIFKSSILYDIAELEHPASTDTSLSSLSIRKHGKTSELELVRRSRMSYACLDELFALAAVNDSGIHPTYPPSRGIIDSEELQRLAATAAPYLVLRAGHVLQHYISDQPLRGRMPQPVRQRKEMLYVLKCLVNLESGVKTVSTDSGHIPPSRKRHLFRLFPLLSQCVAAAQGDQEILGWLAKAMDEIGGALGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMS6</accession>
    <name>A0A2T6ZMS6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_229283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMS6"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="17723" checksum="BCD133567A36EAE7" modified="2018-07-18" version="1" fragment="single">MSSRSLGGGSSTRGSANYSTSVRLDDNVPANVIVRAGKNLREAIDPTEEFLLPAGEKRVVMKCDKNDPTTAIFTFNRDGQTLGGLLVSALLALPCVTFAAYKVSHPLFFVFELRLTTDGAMSPKEALLEASKNMVEDLVMLGRRFTHEWELLKQAEMAGGVGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMU9</accession>
    <name>A0A2T6ZMU9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1129125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMU9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMU9"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="263" mass="29889" checksum="DAE0A621901F9481" modified="2018-07-18" version="1">MDFDSAEYLELQAACKARGIRAVGSKEDFIKRLKSYKSKKDTEFQPNRVDPEGETSDRLVHCRRGQCPEDIPAIVEATRRASTAFTEALKLSNKNLAELQLQIRSFDKRLNSLTALPSPYHHARNQFLSTFKKDKLGRATEDDLKIIAHRDVKGEWADATTDALLYRGTMGRRDFTTFKALYGLQPEAVRKIDHMETIGALNIHARVIASYDQTGSPRFYALFDDFIRVFKESGYDVGYLVGSPTEVTNAYWEFKGCIKTEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMX4</accession>
    <name>A0A2T6ZMX4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_221172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMX4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19975" checksum="38206FCA50A46EB6" modified="2018-07-18" version="1">MTKLSRPFLPFFHRSRHRSIFFHACPRSPICPPFPSAKNYHASKERTNVTKKTSSRSIASAHPTIPSGNAWIPSTYPKGLSNDNRKGFTYAELSGQHPRTSSRQTYRSRAHIRNRCLIDKEICFLQRACWAVAKGFNTTQMCVACVYLSCFYTCEASIHPSPNTTRFLSNLRDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMZ3</accession>
    <name>A0A2T6ZMZ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1148128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMZ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMZ3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="204" mass="22862" checksum="0C01416DE12A46B9" modified="2018-07-18" version="1">MDSTTKEEKLMKMIEDFSRPLFSPPFIPSSTKLTYIPHPPRSNQPIEPNQPTSLPPLTPGTILVTQVDSVPGSSNPDPQLLEPLRFFRIERPMLPPAGTAPSSKYPIVVPVPVTLGLFPDTYCTRQKNPLVFLIHASRNPFRTHREDVFEVLTADTSRAHSSLPLQNNALQSAYPHFPACSLRMPLLFPWDDPLLAQNRQLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMZ9</accession>
    <name>A0A2T6ZMZ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rdx family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1066301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMZ9"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14679" checksum="4097B9A0E0B8ADEE" modified="2018-07-18" version="1">MSPTYYSKITITYYSGNEEWLSKATFFAQELQSTFPTTLNEVSICKASNDEVFTIKISVSKDSNGGGASTNEAVLWDRTINIGFPDVESLKGAVRDIIEPGSGGGNIREVEAEDEDEEEYEEEDEGDDLMLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN10</accession>
    <name>A0A2T6ZN10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nnf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1087487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN10"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN10"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="209" mass="22931" checksum="F1B9AD3952C85FFB" modified="2018-07-18" version="1">MSDPNLPDLVKGEEDKQQPEELVEGIRATALRNIFTAALDRSIKTCSYENFAACFPTPARRAPEVLRNAWEQMCGFWESSAKREYETILKERNVVSGLNALDELTKEAEERRAKAVPGEVAVSPSTLPPATILTAQLTPLLLAAQKEVAGKIEVVQGSNTELMGKIEAQRREIEELVKLLEGRLGMLDGAVEVVVAGRKEVVGEEIMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN44</accession>
    <name>A0A2T6ZN44_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000171">
        <property type="protein sequence ID" value="PUU76876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN44"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="66" mass="8163" checksum="131D3008AC8902E8" modified="2018-07-18" version="1">MYRECWNKFLFFSFLFHWGPGIGIWLLLLAIFLYLFILYYIIYMVLGFTSLCFTWLRFWVVFLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN65</accession>
    <name>A0A2T6ZN65_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1087294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN65"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN65"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="64483" checksum="936D94795C723076" modified="2018-07-18" version="1">MPVLGMMGAGGFIDGLGVPSRPLREGDAIIDITGDATNERGYPASTCPTPPQEFGPGHRQATAEADVCFPVDDGLTDDDEVATLHGGSVRAARRRAREWPDLSVLEEWSRDEKEERSEGIRAKKTAEPVYVGGRLRAPRRTGWHREVEDEPYRFTYFNDELPATIHSHTISELLQPGQTFKDLFRPEPRILDDSSDDEDDELPQSEAESRNSNGRGTGDDSAVRASPQNAPRPVRIGPRPTFWLDVMNPTDAEMKVFIRAFGIHPLTSEDILMQETREKVELFRSYYLVSYRTFEQDTNSEEYLEPVNIYFVVFREGVISFHFSLTPHPANVRRRIRQLKDYITVSSDWISYALIDDITDAFAPLIQSLEEEVDEIDDAILQMHLTANSDGTSDKKSNAGSSTSDGTEQKSDGDMLKRVGDTRKKVMGLYRLLGNKADVIKGFAKRCNEQWEVAPRSEIGLYLGDIQDHIVTMVGNLNHMEKILSRSHSNYLAQINIKMNERQEQTADVLGRLTVLGTIVLPMNIITGLWGMNVLVPGQEIDNLNWFWCITAGLLVFGFLCYFVAKRVYKIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNC2</accession>
    <name>A0A2T6ZNC2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate decarboxylase-like protein-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1128893</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNC2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNC2"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="507" mass="55460" checksum="6B1506F278F21257" modified="2018-07-18" version="1">MSSPSRKSSQMKACEVERLLKLAQSHLLPHISSADDILISDYLPPRKLKEELGLELPTQGRGERGLEEILKKVLKYSVNTWSPGFMDKLYASTDAVGVVSEVLLAVLNTNVFSPSSSFPQISHYGFRVTPWGKSGGYNAYDTEINQKNKKQNTVSPALTIIEKETASSIARLFGFTSGHAGGLTLPGGSASNSTSMIIAKNTLFPETKVSGNAGYKFVVFTSEHGHYSVEKAAILLGFGSAAVRSVPVDEEGRMVVPELESAVQKSKQEGYTPFYVNAGAGTTVMGSYDPLNAIADVCQRHNLWMHVDGSWGGSVVFSDKHRYKLEGVHKADSVTINPHKMLGVPMTCSFLVTGDTRRFSKATSLKAGYLFHGDGDEEEVFDMAQMTMGCGRRADSLKMALGWIYYGKEGYEERINHAFETASYFATKLSQNPNFHLLSSNPPPCLQVNTTTTRAIAAKLIAKGFMIDYSPHPIHGEFFRAVMNASTSKNTVDRLVSAIEEHIVLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNC9</accession>
    <name>A0A2T6ZNC9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Tuber borchii white collar-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1128894</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNC9"/>
    <dbReference type="SMR" id="A0A2T6ZNC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNC9"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000063">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="487"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="617"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="822"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="716"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="864"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="718"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="924"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU76985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="954" mass="103814" checksum="3F19717ED1AC1A67" modified="2018-07-18" version="1">MMMMELDGNEYDRYLAASNVFSNLPTGRNASARGTNGHGSHGHSVVDRPGVGGRRASTPGMVGAVGMDEIVAENARELRRRSLANGFNLDYIGVGESEADTFSRMVSPGGFSAGDMNQMGNEMGRLPTTIESFSEMDASAPELSAVGMMGVGNISGPEIQSSISMYADQQVLSGTSHSSPVTNSMAVSVPQSPVGPQMSGSPLGPGSHGHRMSVDSITSAPMAQMHMAQMPNQGMDQSLMDQMGGMTPSSQYSPMDVNKHFTETTYSSTGFDMLGILYRVANRPNPQINIGAVDLSCSFVVTDARKFDNPIVYCSATFERLTGYTKHEILGRNCRFLQAPDAKIVPGVKRKYVDDDAVYYLKNQIQAKKEAQTSLINYRKGGQPFTNLLTMIPITWDSPEVVYFVGFQVDLVEQPGAMVNRNKDGSFAINYQYSQLPTYVPAAAAALVMDPARSGLTVARDDVSHVLSSFGSGDSEFHSKRILDKVLLENTDDVVHVLSLKGLFLYCSPSIRKVLEYEPQELVGTSLSAVCHPSDIVPVTRDLKDTSSSTSVNVVFRIRRKFSGYTWFESHGSLHTEQGKGRKCIILVGRERPVYRLGWKEVQVAGGIGDNELWTKMSTSGMFLFVSSNAKTLLDRDSEELTGTSVQALMRPDSKNELGRALENAGNGTKATVKHEIQNKRGQFLQALTTLFPGDGTESQKPTFLVAQTRLLKHTRASAGSPTKNHQSDTLSSAASTPSWSNNSPNQAAHMTNGAEKTPPDSREDSAETTADENLFEELKTTRSTSWQFELRQLQRTNKRLVEELSSLVALRKKRKRRKGVDQLEKDCANCHTRVTPEWRRGPSGKRDLCNSCGLRYAKLIGRVSPRTATSNSDKGNTSPTQSQSSPLTAHSLGDSPHLSSAKTAGMTPIPISPVHQQLRRGSMSGNMPTLQPHPTSAPHINGNGEVEMKINGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNH2</accession>
    <name>A0A2T6ZNH2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_988524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU77006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNH2"/>
    <dbReference type="OrthoDB" id="5395245at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015431941" evidence="2">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="68" mass="6958" checksum="F60E335DC9D77A61" modified="2018-07-18" version="1">MQNFSILTVFTLLFAALALAAPVVVDRQIKPEGVNKYGDDGVPSKTDGSGEVVPVVPGTAKGVSSSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP53</accession>
    <name>A0A2T6ZP53_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1194161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP53"/>
    <dbReference type="OrthoDB" id="2959714at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="283" mass="32652" checksum="3516ADDEB2D2DEBC" modified="2018-07-18" version="1">MAQVWSPSPQLAQAWSPSAVSMESVFKVLNDHDHPFVMVGGYALPWMGVPVHTGYIMDILVRTSQASSIHQSLAQTREWIEVDDASIPGLVSFAERQEKRSVGRLKRLDDHWYICLCTEDTYKLMVDTKKIQVPHPISLNAGLVESEFHPNPADRRVRPFLTTDKNIKFVWAEPVTFPVFIPTIPEYLDSCLSCTGGRSHLDDELYSIPEGDLDYLSRYLALDLPHQQDKLLPKVHQAKLLEDYFINRQRRQEVRMKKILERRRKRSSQFNSQPQLPWATLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP82</accession>
    <name>A0A2T6ZP82_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1101943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP82"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP82"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="31667" checksum="B40AAE8F76014372" modified="2018-07-18" version="1">MLSQLINYRRTLQPDEKKSYIDAVLCLQGLPAALSSTIPGAVSRFNNFIEKVHLNGQFLPWHRYFTAVFEDSLRIHCGYAGGQPYWDWTLDIKPGQAFANSPVFSLTDGFGGNGPYIPCAEQPYNLFCLANGTGGGCVSDSPFKNAVLHLGPGRNIESNNHCLTRNFHPQFPARWLSEAEVNRTMAEGSYGRFWRHLEGMFEVERMGLHGAGHLGIGDLLFYLHHANLDRLWWKWQEQNPQPRLKEVSGPVSQKQGAGNIAGKVNIADVMHIKQKALCYDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQT1</accession>
    <name>A0A2T6ZQT1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUR7/PalI family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_985445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQT1"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="320" mass="34695" checksum="6A54A548CB5A691E" modified="2018-07-18" version="1">MGKAGRFACILTPMLLTLASLCCVLIVMIGGTNKNSSMISGLYFLRIDTRFIDTPENIDLIPGTDWDNQLLKSGFNATASELGLDDFYTSSLWNYCSGKVSGDKWDINNCGKPSASYSFDPIRILDVEAEGKDVNFPDSVKKVSKAVSAASKVMLAMYVLGTISTIITFAVGWFGLLSRWGSCVTTIFADIAFFFLLTASIISTALYVSIREAFNKALKEFSVNAQINRQMFTITWLSVAFSLGACIFWMLSTCCCSGRRSRVMGTDHKGKGKSTSPIGGGKAGYERIATPYHGGSGSGTKPMSEVGKKQAAGYEPFRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQT4</accession>
    <name>A0A2T6ZQT4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S17-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1085397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQT4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQT4"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="18516" checksum="B62615FD11B9CC3E" modified="2018-07-18" version="1">MATELTVQSERAFQKQPHIFLASKTRPAKRRVGKGGRRWYKDVGLGFKTPKTAIEGTYIDKKCPFTGLVSIRGRILTGTVISTKMHRTLVIRRDYLHYIPKYQRYEKRHKNISAHVSPAFRVEEGDQVTVGQCRPLSKTVRFNVLRVLPRTGKGVKAFQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQV1</accession>
    <name>A0A2T6ZQV1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1049616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQV1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQV1"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="892" mass="96727" checksum="D3F865B332E1B4FD" modified="2018-07-18" version="1">MLYSAHLLYLAADAPNPRGRVLVAAGTVFGEILLWSVAITPFPSSGIHDLQIPKTHYRLLGHEGSIFGVNISPKCHGDKYYLASCSDDRTIRIWDISQFDSSPPTADGSEIKRTGFGHELTRGGGCISVGWGHGARIWGVRFLPVTEESLIELLSISEDLTSRFWTFNLEQKGAGSIELKNTATYRLHSGKHIWSYALDFERGLLATGGADGRIGLIHYRDDQESREEAWDMDSVLAQIGDSREEPGEPSHKDKKAHDAFKEYAALDNDCFAATTTRGRVLTYTLSQKRWNLVGQWAELKGWSILASWEDSGLIALGDRNGQVGVLDTVSKREWWWQSMAGESGKVAGVFLGSYYILTTALSPTIFSLHSFKMDRSKSPSVLIDRETLSLHSPARAGETKFLVTSLAVNQETNYLLLGSRAGTLGIYDLSSTVRPLWALSHTLVHPTDAITSILLLKPGILTTSRNGEYSHLSISSPPNICLTKTHSLKPSLVIEGAGQLDNLTLWGFRGKHFMVINQASQHEAHSVECGGAHRAWTYRLNEYFVWTKAGKSHIARTYPRRKLLQSGLHGREVKSIATHGDLIATGAEDTLLHLSTLSPTSGELCLGTVVGTHTTGIHALQFTPSGQYLFSAGGAGELLAWRVRSVNEIVLRGACEGWSDLRVEGFDLLPVGGGGGGEDGVLLAIGYSDSTIRLYYFSPSTGTFNLVMKGTYKACCILHIKFLPSNDGILVAGTDGYLSIYPLSDPCSLTSLPHPLPLPRKSVEKRVHQSSIKALKVVVGANGVCVYTGGDDCAFGVTRVDTKYNVAESWIVPRAHASAVTAVLCVGGHVLTAGVDQQVKLWKVSEGGEGIMVEAQEQQESAVADISAAEMVGGKVVIVGVGVDVWEASARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQX1</accession>
    <name>A0A2T6ZQX1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1127665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000137">
        <property type="protein sequence ID" value="PUU77881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQX1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQX1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="123" mass="13021" checksum="5ADE5F156816A6C8" modified="2018-07-18" version="1">MATKLFIRSLSWNTNDDSLRVKFEEYGQVTEAVVVKDRDTGRSRGFGFVTFADDKDAGRAITAMNETEFEGRRIVVVVAEDRRSGGGGGGGGGGGYRNDGGYRNDGGGYRGNNGGGGDGGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRP3</accession>
    <name>A0A2T6ZRP3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1084689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRP3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRP3"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU78165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="375" mass="41652" checksum="158D697614F93343" modified="2018-07-18" version="1">MEDEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAISRVDMAGRDLTDYLMKILAERGYTFNTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGIADRMQKEITSLAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSC1</accession>
    <name>A0A2T6ZSC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conidiation protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1048633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSC1"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="10567" checksum="C11172B851C3F975" modified="2018-07-18" version="1">MDSTSDQKDLGNVIRGHKANLHNPNTSQEAKKHSKEVLEELGIETSGFVSEISGPDVNIEGKNPGNVAGGYKATLHNPNVSEKAKERAQEKLEEMGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSG2</accession>
    <name>A0A2T6ZSG2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_983244</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSG2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSG2"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="523" mass="58605" checksum="A747521DBCEE2EF1" modified="2018-07-18" version="1">MSKEEPEQNKPYIEQKIPAYDGQHEVGFVQEYTPAKRGIELHPKPTADPLDPLNFPRWQKWTALGTVMWMYFLFTYITTTTVPSFPLLQEQYSISYSQVNWTVAIPALGLSVGPLIWSSLSDIYGRRLILIIGTAIALVATIGSAVAKNYSGYMAARFFQGLGVAPASTVGMAVVNDLFFEHERGQKFGLWVLAIDMGLLVGPLIGGFVTLVNQYWVAWLTAILFAVLLVAEILFFPETLYPRKLMLSRLPTSSGFHTDSEKTGTVSASNDIARTKQLPFLNIWKVPGIEHPKPWDTLIRFIQMWTFPNVAVAVVVYSFAWYWWVMSVITFLPVAYPNYKPQIQGLLYGGMILGTLFSEILCSGTLSDWIIIKLAEKNNNVREAEMRLWLLYPAGVITSVGLIVWGISVDKGYHWIVGQVALFLFAAGIQMGNTAICSYIVDCYPLHAMPVISFYVVLLNLSAFANPFFIAPWVDSVGFTWTFTTQGLLTAFVAIPALSVLHVFGKRWREKRGAPKWVSAEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSJ4</accession>
    <name>A0A2T6ZSJ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1101377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSJ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSJ4"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5672" evidence="2">
        <location>
            <begin position="152"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="362" mass="41112" checksum="10AA0BB169AD1D11" modified="2018-07-18" version="1">MDHAHEKYNWLSNHLPFKTAGKKILIIGTASVFALWFLFLFGPSAAKTVSGLNLPSSANGVSPDLLPNVTCNPEPIAEVQKPHEEPPAPKFNESKVALLIEDRPIAHLAPLLLHMISVVPEDWKFQFVGSEKSIQFLNKSLAVQRQEARGKLEMVTLPDTWSVKGQEPLSRTMTDIEFWKWIKRTQVEWVLIFQTDSIMCSNSGVSLNSWLDYDYVGAPWGPGDGFGGNGGLSIRRVSRIIQVLENDHRPDNDGALEDLWLVQRLQNLPGAKMANGTTEQRFSVEQVWHDEPMGYHLGWSGARLPEGVWNEKEHRDHIWNWCPEIKLILSMRLEREGCPDGESSKLKARTAEEDWTRRLKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSS1</accession>
    <name>A0A2T6ZSS1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1084113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSS1"/>
    <dbReference type="OrthoDB" id="5328449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015723592" description="F-box domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="37577" checksum="EBF17400148A708F" modified="2018-07-18" version="1">MASLGFLATELLLNIVQYVAETPEEFTIIDGSKEQPPLKNLSLTCRRFRAVCFSFLFRSVKLSLENGHTHRSIRELRGFIRDNSLERTIESMGLAMRPEWNGGKVGLELKKFLWEISVKSLSIRQHRNPSLREKSARWPYFLATLERLRLEEVDDDNDLKMLLLKQCPIRLLYVNDGSFRSLYGNDNYFVGDAEYGPGIAAFKPSAFPNLTTVVYHAAWPPFNRFDGFLEFVAKLSTIEVLEVKLMGDEDLELDLERKAYKATLDTVLWTEMVTAYQILAWRVGTMGSLQRLVVRDHCIPFHGKTAPPQSFTEGPIGTYQKQKDAQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSX0</accession>
    <name>A0A2T6ZSX0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1141958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000115">
        <property type="protein sequence ID" value="PUU78575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSX0"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="301" mass="33980" checksum="5CC13AF6403C87CA" modified="2018-07-18" version="1">MNNDTAKNHITTLPTMSSVYSSAMFLTRSSNGNLGPIHEHPHGAHYAQTPGCSPNPNEAASMVPTSPSTGDSSMLPQYPCIEEDAQALGLEQNSHEISGISDLAAQGDSSQTYSMNDFLSQQELLRQQDSKWFQRYQDQAKELQAKFFLRSQECQAEWYERFLYGKTDKMIFEENFNLCGALVTERMVYHAKLLKKIGADWALGIQSGLDEISKAPAFTKLLHEQAAARGLVPKDIIPCIAFVYDKAYKHGARGNDSIITLCKDDYTVKELAVLATFLRLQSEWPHGLEWREERRRRQPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU71</accession>
    <name>A0A2T6ZU71_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1082941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000103">
        <property type="protein sequence ID" value="PUU78954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU71"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU71"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015632546" evidence="2">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="329"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="436" mass="49674" checksum="5803FA2C9EE54682" modified="2018-07-18" version="1">MSIPLTSVVRVLYAAAVLFPQLAATNSMCRLDKAGKRTGSTHIEVLCGTVFDSIALSTVSKRIFKSLSSMESSVADTPPSAWELEDIDYKTLMEDEIVIAVMGVTGAGKSHLIRQVTGLNEIAVGDGLESCTDKITSYRFKHEGLNITLVDTPGFNDTYRTDTDVLLDIATWMEFSYRENFKLSGIIYLHPISAVKMEGSALRNLRMFRKLCGEDALNHVFLATTHWKNVPEELGNKRVKELRENPEFWKGMLSRGAKVAKYLGDRESGLDLIDVLVKMGRVTLGIQHELVNEGKELYETAAGEAVNAELARLQKNHEMALSAVRAEWVQALKDKDDELKEVLSEERQRIEEKLTQVENDRENLRRERRREIREQEDEWHRRVKHMEGVQQKEREEFHQRFNDLQASVRERESGIPWMSVIDLVVKGLVHFMNVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUW4</accession>
    <name>A0A2T6ZUW4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S36, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_979949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUW4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUW4"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12639" checksum="033531357D3A4688" modified="2018-07-18" version="1">MSASKVLRASTTGRTPLIQFLGKRSIPEPVDHTPRPHPAAPTKALPNSFAEYRKEAQQHGPLSGYKPATAPRAPRAPSISPGQGQVFDRSQLPPRFWRLTLSKQEMEVVESGGAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVA6</accession>
    <name>A0A2T6ZVA6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1125305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVA6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVA6"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF3">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="303" mass="33321" checksum="7A2214F5F19B022E" modified="2018-07-18" version="1">MNTGHYTFPTPVISSMPSATHYNTRPTTRVTNSSTTEFRGSTNPDEDWTKISDLAERRRIQNRIAQRNYRKKLKRRLEDLERRAASRSLSPNGEDTDGRSTRESSAEQPIVSPPPPPPQALSEAPLSRENYLPPLNTAYTTATSYSSQYRSAASSNSSPFSSSSPTPYYPSASAPVNDAASLPHYESPSTHYMYAYSQPALSSVVEATCGSGISSSGPEHTYLPLPSTRISSNNYHHSYSDFITPKTTSVFDENSMNPFYLSYAGLAESPDPSFFSSQYYHDDHSSPSSTTSAHSPPIAIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW15</accession>
    <name>A0A2T6ZW15_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_978558</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW15"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW15"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02660">
        <property type="entry name" value="Peptidase_C19D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="41"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="6">
        <location>
            <begin position="189"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="524" mass="58802" checksum="7C6AB4FB63A78728" modified="2018-07-18" version="1">MSPTTVLKRPQASSASALLASPKTVKNSKPLANSSVASLAYGCDHIKKVLRSPAEGTKTKTNYGSAARVALDSSRTHAQTCVKCKFLITRTFLCMQCPGIYCPKDAESHSKENKHYFGIDSRSGHVYCFLCQDFIYDRALEEVRMEKEVAMEGSARKRRRLDDTKLSLKDLEYIEAHTTLAPCRATGLRGFINMGSTCFMSVVLQSLIHNPLVRNFYLADGHKPKECLRTDCMSCAMEEVFSEFFGTDRTDGFGPTNLLTTSWKCEQTLAGYQQQDAHEYLQFLLNQLHVTNGGNSDTKTESCKCIIHRAFYGKLQSDVTCEGCQNVTTAVDPVMDLSLDLRKKDKRKLDAPKSEGEMQTLQECLERFTNTEKLGMNEYNCGNCSGHQEMATKQLTVKRLPPVLCIQLKRFEHGSTKSSKIDTKIRFPMQLDMTPYTTRAKRKAKDGSTDCGPKSSLKGHGPYLYDLLNVVVHTGQINSGHYISFSRENGQWFRFDDSMVTLATEKDVLSAKAYLLFYIVRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWI9</accession>
    <name>A0A2T6ZWI9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000079">
        <property type="protein sequence ID" value="PUU79862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWI9"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8761" checksum="5F413358AFEF0D47" modified="2018-07-18" version="1">MRITEPRSKLRLITINVHLGNMVPAPPDWTSFALTLLSVIGLTAVVVTEYRLKKAQLRIRRKAGEGVLALQLLLWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXG5</accession>
    <name>A0A2T6ZXG5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1080121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXG5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXG5"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="170" mass="19175" checksum="2012B0BF8A708709" modified="2018-07-18" version="1">MKGSKVAFYFAVQSGGSFDVDYKVTGPNGKVILDGSKERQGDFVFTANEAGEYSFCFSNDMSTFAEKTVDFEIAVENEARAELPSKQGTSPEHLSSLEESLFKLSGQLSTISRNQKYFRTRENRNFSTVRSTESRIFNFSVIESLMMVTMSCLQVFIVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXH2</accession>
    <name>A0A2T6ZXH2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1124051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXH2"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="645" mass="70535" checksum="500B5121294E02B5" modified="2018-07-18" version="1">MADQTKTAPVDEYRVMWTTNKTQKIKKWHDGFLRYHSFNRRMLVYDNGRHLVADMYLRDRELLDEGDELEFEHHLVSIEDFNGSVNQDLTPIFSPALQRKQAAAKAASSVQTPIPNRRREPAGALRGGKTGAQSARQQRPAARGPYTPTPAQGESRNGHMTTPSRPAQAPATVPRMNGQGEGDGVINLNTPGRQDHPPGAGSGRSRQVSGHMGMDTPGPQARAPMPAYMGNGHGNGNMNINTPVRNSTSHNPYPARQHAIYPPQANERPINFRSAESPVPQRAPPPAPPQPVPRRQNPNSRPVGRTPPLATEKVVHPNAQSPTYRPPQHQQRNGVLEKGGPATASRQIPTQANGSENITRILPPMPQGRPISRANQTHPIPQQTEPPVQRRYSPPAPEPRGHPPPAPPRVPSPAPAPPPAPAQPLSDELAFTAPATVCKIRQFSAPSRPRPPRQPTAPPPPLPQRSPESIQVPSSAAEPPPHISRSPSPRNRPLPPPPLLQKETSIPNSRSPSPTRNPTNRPPKRPSTNSGANQPPTKRKTQFQSAGRLAEQEQDEIHDVDDSDDDNNVAGSIRQGAGVIKLSSTSGPKKKMLLCARPPTFKFPPKQPEEGVNGNESENRERPKTVIVEEDYGDWDEDDEIMSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXY8</accession>
    <name>A0A2T6ZXY8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1113954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXY8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXY8"/>
    <dbReference type="OrthoDB" id="5401166at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="44"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="308" mass="33183" checksum="E3B49D802731BDA5" modified="2018-07-18" version="1">MAAKVPVPNSWEDDEWENQPAKLPTTNTPATVVTGILRSDAVEFTPAQPLYTLASSQPKTFFKPELKILKRTPSPNSSTATADALKISTEKPQSQKQEIELERRERERKERERRYQETRDKIFASPVAAAKPKRKFPSPPRTTPARNAPAPAGRGNGKSNKTGGKGGDRGGGAITSFSLNGGDFAVAPPPPKIWGVDEKMLESQLAIMSESMAAAATMVKDGEGAEEGLDWDSFERGSWRPCDDPPVAPQYNNNSQGPTPPSPAAPAQDKRLGVLRAPRGPDTGGGKGFKGRGRARDAKEFVPGNTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY62</accession>
    <name>A0A2T6ZY62_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1171883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY62"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="296" mass="33513" checksum="2CEFF9A4840DC0F0" modified="2018-07-18" version="1">MRHFLRPHNRFTATLRTGSFRHLTQGVRNSPDHCGKLAANNVQQSHGTPTTVLAQSAVFKEIEGRWSKRLQQQSAEMHKVFDKIEVMWINLSKRMEAGTLNTSAKFAKSCDKQRTTLLNSFNELRQQHENKAETLVLRNSDLFVGLSLLCLNIGFLISQQYAVSEERNAKMKVQRKYNICGALERMVFLAKLQQKVPPAAGVQQGLRKLARSGEFTAILDKEVEARKLDARDVIAGVSRLYRKASNGTNGNDDIITIRATKFNDNERAALAVFLKIQSNWPNPLNWKEDTSCKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYA3</accession>
    <name>A0A2T6ZYA3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WLM domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1107061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYA3"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07344">
        <property type="entry name" value="M48_yhfN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="431" mass="47090" checksum="12767ECD4D4DFDF2" modified="2018-07-18" version="1">MRDNGLAVMSLDEFPANVEFWGRNFNAGEVIQLVLKNPNTGSWLPFSFVLGVMIHELAHVKQMNHSRAFWSVNNKFSAQLRVLRAKGYTGEGFWSAGRTLLSEQYTHDQPLAEKDMPKSLCGGTYRSHKKRESTQDASGRAKRPKITYAERQQRRKERKFGPGEGDKVGADDDTRSVLEKGKKSKAAPRIAQSARGRELRAAAAVKRLEGQKVDKAEEEASNESGSSDSEGTGNWDENEKKVDVGGGKYLVPVSLEDDGDLEQDWMKRELVELKDACGRGTMGEYFDEEGGTSGNGKEQEQRQSRGSSSKMSANKDTVDLTNDDDPQAPPAPNNKPPTPNPPPPLNPQNPTTPSPSRSKAKTPSEPSKATCTACSFANDPTSTLCCVCANVLNPGHMKNAWKCSCYGDLPYMNPGDAGICGVCGKKDGRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZT6</accession>
    <name>A0A2T6ZZT6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_674136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZT6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="163" mass="18219" checksum="81DAF4745BDCED63" modified="2018-07-18" version="1">MSPSTETMRRKLITALWGIHTLSFQHEKEVQEPPHANHRTSMVKPKVHNPELQPSFHPPPPLQPLQSLLIHSTCTHNHRKKKLLTVTPMRLSLSAGAYRSVPAGLVPFSSNWEDSRFSFVSIITTGATASPGICTNQRRPALQSRGEPTQLAWREDNVAYSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZU1</accession>
    <name>A0A2T6ZZU1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1078299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZU1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZU1"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="551" mass="61590" checksum="4CE23B352189AA35" modified="2018-07-18" version="1">MPSTPPSGAPSSKEKKYDRQLRLWGANGQNRLECAHIALFGATATGCEVLKNLILPSIGRFTVIDDKLVAEADLGVNFFLDQDSLGKPRAERAAALLGELNPDVVGGFRIDNLENMLSNTPELLDPRTTEFTHLLLMSPVPTPLLLQLPAEIPIFFVHSLGFITSLRIYTPTHTIVETHPDSLVDLRLFNPWPELLELALEKTRTLDVQESEGGMSDQQHGHVPYVLLLLKYLEDWKQSHEGHLPRSYSEKTLFKSMVMDKMRTNVPGGGEENYEEAIGAVMKNLRTAELSSGTKEVLNDPKCQNITSQTDEFWVIARAVKAFADSNNGLLPLSGAMPDMKAESHGYVTLQNLYRSKARSDAAAVERMVWDHMSRVQHPKRNQIDRDAIQLFCRHANFLRRLNYRSIADEYSGSSEEHKRAVLAALGDWDAEDSLINDYIALRAYQEFYTSHGRAPGDTSHENCEDDYQKIRGIICQYLEGVGYTESPPERCEKVAKEIIRAGGGELHVTASIAGGIVAQEVIKIITRQYIPINNTVIFDGIASRTQTFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A056</accession>
    <name>A0A2T7A056_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A056"/>
    <dbReference type="OrthoDB" id="5450301at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="21119" checksum="F2C2C14B2D1E511B" modified="2018-07-18" version="1">MSYSSNEGMSGHSVPIDRGISPSSGNEGTIPQSPNSSCILLQALLDPANANTRPAPLACPVSGCSSVFQKKAPHGYLWRHLKRPRADGRTGDEKDACENLHRIEHDRLLSTRLNPAERKREAREVKVEKRLRTTEFELRARSMGITEDALVAQKVKFWEEMWVAKQNGEDIEKLKYDALVLLDFFTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0M1</accession>
    <name>A0A2T7A0M1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0M1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="16478" checksum="AFD177876DCD0472" modified="2018-07-18" version="1">MREKRKEKNAPMSGTYGSTRMAGTRFFFLLVFSNVFLGREYGDRTRLLSLAELAAPSEQSSVCFFFLFSLPHLLFHQPHCWLCLDPFFPPTAWGLMRWWNLPFPAFFFLWMMSGSCQARWLRVASVIWVVVCLVNYYCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0M4</accession>
    <name>A0A2T7A0M4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1077470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0M4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="8137" checksum="DF9639E38CFDAABD" modified="2018-07-18" version="1" fragment="single">MVFVLSCLEMRLGRYLITILLMDECDGTVYCTVCTCARCDAYSSYMICKGSLVLTWVSYLFILTPAIGGQGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0N8</accession>
    <name>A0A2T7A0N8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1019961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0N8"/>
    <dbReference type="STRING" id="42251.A0A2T7A0N8"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="366"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="655"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="919"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1189" mass="134425" checksum="8EE4DBEC93DF7517" modified="2018-07-18" version="1" fragment="single">MDYLRRVRNKQKGRAEMHRMGTGASSSTAGSIREGEGTTYAEASADTLEEGPGQEEEEREEEERFGLFVVTPEDRDAMVDIVALHGLGGDRFQTWTHESGACWIRDFLPEQIPGARIMTFGYNSGVAFSQSVSGISVFASDLLDRLKGLRRHVNESTRPIIFICHSLGGIVCKRSLVLSHEQPVYQDILKSTLGIVFMGTPHRGSTIADWTRMFTSIVDSVLIGTRMRSDLLKDLRTNSRALQEITSSFKYRTSGLQIVTFYEQEITTPLKKLVVDMDSAILDLPNERPVPVNANHREICKFSHAKSEKYRPVWVAISDMASSIQVDHAVAAEFKSRSEAQEKCLRMLAGVDASSILQAITTRHRGTCEWISNEPQFSEWETGNNSGLLWLYGAPGFGKTVMSKYIIERCEHRETSLVAYFHCDSKDESRKTELNTLRSIIFQLLARNSRFFEHVLKYMEMERLGIMTSFSTTVSALWKILEDICATSAREIRIVIDAVDELSTTEVPQFLQRLIDLVVRGTGAQSALKVAVVSRPELEIQRQLSLPWVGKIELSSTRSQKDIESYLSETVGKFAAENDFPDDQRDAIIEALRTRSDGMFLWVTLAWTSFVGGDGDWSRAAIRAWINELEHLPRGIDALYRTMLKKVPESKQPKTRLLLTWLIYAFRPLKVQELGVVLALRPFHSSHYDLEENLGFDPEKRLRSLCGNLINIRDGNVSLLHQSTREFLVSSLSHPEDRFEDGGDFVLDVHAASLELSISCLTYLNFDGFDIRSTPSLSGAYFTTSSVDADTAKVPFVKYCAEYWPRHAALVSDAKAEEVLKLVRRLTENEYKLAFEYQLRRSLLMKSPRKSPPLLHLIVEYGLLNVLLVLEPKVENMNQINFNTETALHVAVNSGSHPHKILRYLLQHQKVDVNAKTGLGETALHYAMRISKESEIEPFLAERRVDLNLRNRDGVALVHLAINNDWGILRRLILNPKVDLNCEDLRGIPPLLIAAYWGKESATRAIIKSRRARLRVKDPEGRTPLQHCIKQDWRDLTKMCLDDDEVGANEIDRDGNTILHLLTSMGWADVVKYLLERKSVNINARNKDDGRTALQRAAEFGSKPVLIALVESGSDLALVDKEKRTVLHWAASWSWEDVVAMLLQKMESDVRARNSYGETALHTAAQCGNRNIVRLLMTRGFDPADKDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0X0</accession>
    <name>A0A2T7A0X0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0X0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015425602" evidence="1">
        <location>
            <begin position="21"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="16646" checksum="58C95285F106A741" modified="2018-07-18" version="1">MGYLLLVNGVLRGVCFLALAGGICPRECSITHRLRSIIPIFLSLSDIKNPYPNRLPQDPPPPLHSHSFLLPSLLISSTSLSNALPFILSSPASTLHSSTPSPAQKPLSSVLCGLYRGPNSPISPGALNSISARPNFSFEFSTGRHRSGFTAQQVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1T7</accession>
    <name>A0A2T7A1T7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1190896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1T7"/>
    <dbReference type="STRING" id="42251.A0A2T7A1T7"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="30368" checksum="BB45FEA935611E4B" modified="2018-07-18" version="1">MELIAFGFNAHGQLSPSTNPSEIPEDIRIPQIIASAANSLRVLFAGWSDTLLEIDGSLHLLGAASANTQLTIPSTHLSQITSAFGDHTGLKGVTTTAQAIHLLQHYGTKQVCFGQRVEGINDTSHIAIAGNGVVAVVQGDEVLVYRSFSAFLLKNARQRWTLAGGVVELHANEGGFVALTREYGGRVITWGDARHEYLGRETTAEASAGAPGIVDALDGIAIARVGSGGWCSAAVSVERDLYIWGGAGGEVLAGRGEVELAQEFEVVDGVSVGDGHAVAWAGGKLWDTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Y7</accession>
    <name>A0A2T7A1Y7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_574037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Y7"/>
    <dbReference type="STRING" id="42251.A0A2T7A1Y7"/>
    <dbReference type="OrthoDB" id="5400080at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="286" mass="32096" checksum="FA4A2BF8894E3805" modified="2018-07-18" version="1">MQQFLTEQQRLDRFAIPSALLEHSDFPPPSSSHPSDLSVAGADCGSSTTHRSDRMHRCEGSTYTTSSMPTLDYSSLTSLSSPTPSTCYHPQMYGFQEDSSGALYTYQSASTPVRTETRPDGTHPCLFFFNGCSEAFGREEDWVTHVGSHFSSKEIPPPSPCICSVCGTPFRAYDPPLNWERFLKHTFNDHYVRDKLSQGIPPHPDFVRYCRDAAMISEFTCTRFEGYQRVISEDDRIPRSSRGRPQRDADIARVHYPGTWESSEAQPRTATTVVVNRSGQARSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2D0</accession>
    <name>A0A2T7A2D0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1062287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2D0"/>
    <dbReference type="STRING" id="42251.A0A2T7A2D0"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015475938" evidence="4">
        <location>
            <begin position="26"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="285" mass="30114" checksum="34EB23A41F760032" modified="2018-07-18" version="1">MPLFLSLPNELLLLIADNLPACALSKTIQTCRHLHSLLTPRLHRLANEPCDTLPPLHWAASRGHTRLVRYLVQSGHNPDACDAMYQTPLLHAVKAGSAGSVSCLLEAGANAIVEDPLLGGTPLHWATLGGSLEVLGVLLKTPGVSVHCRASGSGTSSRWLELRQLTHILVQGGQSVDRVLRYSAGGTPLHWAARGGQVAVVRALVKAGARVGDLDGEGAGVLHWGVLSGKKEIIASLMKAGARDVPDLYGESAADLAAVAAGWAGFGEIEGVLKSRRAWLRGLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3T5</accession>
    <name>A0A2T7A3T5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_968234</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3T5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3T5"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU82402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="411" mass="45856" checksum="5D7BFBDB40A443D8" modified="2018-07-18" version="1">MLRSSLLRVIRTPQALRAHSTQTKLPDIDASKLTITRTQTPKALKKPEDLIFGRNFTDHMLSIEWTAQSGWAAPRIIPYQNLSLDPATCVFHYGFECFEGMKAYRSTVNEKPSIRMFRPHQNMQRLSRSSVRIALPAFSIEEMTKCLATFVNLEQRFIPDKRGYSLYLRPTMIGTQKTLGVGPPKSALLFVIASPVGPYYPTGFKAVSLQATSRYIRAWPGGVGDMKLGGNYAPCILPQLDAASRGFHQNLWLFGEEGYVTEVGTMNLFTAWITPEGKKEIVTAPLDGTILEGITRDSILALAREHLTKEGWEVNERKFTVGEIAKAADEGRLVEAFGSGTAAVVSPIRRIAWDGGVGGTPRDIMIPLQEGKEAGVLAERLWKWMEERQYGDVESDWRLFLPTHPPPTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3X5</accession>
    <name>A0A2T7A3X5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-antigen, C-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_415399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3X5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3X5"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="182"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="530"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="379"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="565" mass="62404" checksum="6C6A480E25B6B5DF" modified="2018-07-18" version="1">MHLLNRGHNHTIPYCDIRLDGNVVVLRGTPEESAGAVLEGTLAFCITESVSVRSITLSLVGVRRLNWQEKTSTASAGISVKPVKSESVVFVKKWEFLEFSHKHPVTLRPDNYEYDFGTVLPGDLPESIEGLESAQIFYRLKAVVERPRFAQNITAKRHLRIIRTLNPGALELSQTMSVENVWPDKVEYSISIPNKAVPFGSSIPIDITLVPLRKGLTVGKIVCNFQELHSLSNPDKGTTKNDTRHVLQQTFENCEIEMEGDEDLGRWRLQDRVELPKSLVRCVQDCEVDHIQVKHKLKFTIQLHNTDGHISELRASLPVQLFISPNLLMGEDNIVHGATSSEGLVLHQNQAPPRYGDHCLDRLYQGLPQDHYETPIQTPLPSRPNSPSLSRQNSSENLVTYSGGDSGRTGPYTLPRVPSHRNTGGTSPSLLSPASPSRTMAEEVAARLSQCGNEDYFSRPVESIGHITRHSGPSTGVHSPDELREGGVDLGALSKVPSYSTAIRSGTRNLSSASNLPTYHNGFYSAPTSLSISPRGSPPSPPLMPIMHSLLQRRKRQTDVEGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4K0</accession>
    <name>A0A2T7A4K0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4K0"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="42849" checksum="5B9963AFB907396F" modified="2018-07-18" version="1">MFEPKQWNVPEVVRATVEKSDGNLNPLQGDGSNFPCHGVAPEAPVATYLPGTSQSLKLKGSAVHGGGSGQMVITYDTNPTKNTVFRVMTSYMGDHPIKAAGNLGPTDRDPQGLKSELELWKLNPLSFTVPKGLPKGKAVVAWTWFNHIGNREMYMQCATVIIGGDETSMNAFEALPGMFKANIGGGCIVSDQITAIDFKHPGPEVFGKGITPVPCGEPSITGSGVAEMVVPGAGNYGQKVESSAGAAVTPTKTSSSSPPPPTGDNAGDDGVLTTYVTVTPSPTPSKEVNIQTPIPSAPTTLVASAIPYNPPTRPSAPTTLVASTIPYNPPTRPSAPTTLVASTIPYNPPTRPNVKTPDACTTEGEITCGENRTWYMCGSGRKQFMGSLAAGTSCTAGKIFKRGIRGYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Q2</accession>
    <name>A0A2T7A4Q2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Q2"/>
    <dbReference type="OrthoDB" id="5348903at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="467" mass="53086" checksum="D54FE27AA92EE411" modified="2018-07-18" version="1">MPPNEDIRLRREALFRAGRLLANEMEATAWNPGNLMVGMAIHKNPSISTVKAVESARDLLREVTVSDNRLRKMDPINDLQPLANIHNTLLQIGGLVSLKQRLYEALQDIKLRLQELQRYTGDNIGQAAAEVHDFICFVTFVNLIHPQQCILTSESIKDAEIIASKIPFFEARQAFVELRQAYQLQTPVPGYRLSKARQLPAITRCIMEQWYKDYLSHAAATGTKIIPFQIVFGWWINYQRKFISSAQEKTTPIVQELIDQAYISKAKIPEDEDEQPWMQEDKEAFKAATSLAMSMTKLCKNIPLPKHVKPDPQREEQLPIHTQFNARPQTPPITRELQKLLAQIYGLFEGNSCAAFTIMTKAYYTKEENYFRFSAQDQKTSSVKHLNAATYFFNSLRQVRVVVLKDQSGRSAGEGKVEVPLLDAVSAVCRDPTITDEEHLAAITCKSLPQVGMHFLVRYRGPVGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Y6</accession>
    <name>A0A2T7A4Y6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B9Z19DRAFT_966618</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Y6"/>
    <dbReference type="STRING" id="42251.A0A2T7A4Y6"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000447">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="26" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13 26" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="25">
        <location>
            <begin position="327"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="91"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PUU82794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="677" mass="75703" checksum="4C806E68028379BE" modified="2018-07-18" version="1">MLNSQVHRGYMPQQPQNVKFFQQLAQPQGHQVDQTMNHVQGNAGNNTVGGHSHSYSSGGLGNPSYVSPQNGVAATLQSASPHWQEQQTLIATSRNSSSPHHHARQAALSNKNSSQAQVTGGINPSAFQPPSAQHRKDGPPVEEKEVRKNDTGELERQDWKSLDLGGQGLRALSKSLFQYTFLDKLYINHNKLTVLPPAISRLKLLQLLDASGNQLTEVPPELGMLTNLKNLYLFDNQLTTIPNELGSLYHLEVLGVEGNPLQPDLKEVMIKDGSRGVILNLRESMQVPPPLAERDWIILDDSSRSGAKSEADKFQVLCYNILCDKYATQNMYGYSPSWALSWDNRKGLIRSQLIESKADIICLQEVDMENFNEYFMPELAREEYKGAFYPKSRAKTMNETEKKSVDGCATFFKSAKFSLLEKQIVDFSSAALNREDMKKTADIYNRVMPKDNIAVITFLENKMTGSRLIVANVHIYWDPQYRDVKLVQVGILMEDITKYADQWAKSFPNRARSPGDTSPLQPAVNYSSGSQIPLIICGDFNSIADSGVYELLSRGSVASDHDDLLGRTYGNFTRDGMSHPFPLKSSYSNIGELDFTNYTPGFTGVIDYIWYTTSNLNVTGLMGNVDKEYLARVPGFPNMHFPSDHILLQTEFQVKPRKEPISKPPPPDFGNNLPRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A517</accession>
    <name>A0A2T7A517_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A517"/>
    <dbReference type="STRING" id="42251.A0A2T7A517"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="481" mass="50465" checksum="F38BF6DA6D1F89B4" modified="2018-07-18" version="1">MNTDTPNATILRETSGTTTSSPKAAIELPDLSAKADTETIGTLEAGLYGMLTENYEMVFEAYYAMRLAVLGDDEEEMEREGEKEKEKEDGPVVAALVGQVAQKNKAKAEMGKEKGATIKVESPILKSMTGTKVTKKTVVRGLKDRIAQKAKAKGGVEKEKGATIKVESPIPEPMAGAGVTKKVAVRGLKDRIAKKAKAKAEMGKGKGATIKVESPILKPMAGTGVTKKAVVRGLKDRIAKKAKAKGGVEKSKSITAAIAADRVTRLSRSGAPSPEALCAPQHRNMGIIGLIQRSAQKEGLSAAAVQVEKEKIVGGLRGKVASKAAIDGKSAILKPRAGAGVMKKAVVGGMRGRIAAGTKGSIGIAKEVENQSITSATTTDKVIDTPRGRTSPEVLHSAQRRSVRIIELAQKSALKERKSAEGALVEGRKIAGDGLSRQIAVAVLIDVKPQILKPRAGAGVSKREDSGKLRGGKKPSVLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5E5</accession>
    <name>A0A2T7A5E5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1190015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5E5"/>
    <dbReference type="STRING" id="42251.A0A2T7A5E5"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="648" mass="73661" checksum="BCE03A29E07AFD3E" modified="2018-07-18" version="1">MDDPWTNSAAPLDPRSTQEPSAGSVHEMSQLSPLLPLLSPKSEDGFADWETIGERRDFYDEQDFLNPSYSLASEKLKNRKEDDVVIFDYSIDPDYLSRLDGNPPVEGGGPSLGRFSGDTGRFFRAPKDRLVESKQFNQVINPTKDPRLAQSLGPRLGIIDFPQCYDTYDDSLLNSIGEKLGLLREGETACMDAYSQRVRALPGRGRFRTGISLRASFREPFGPPKSGSSEDGFILFVSFPYFGESSKNISLDPETESIKLLDFKGLGVEASNCNAVVSKERDDIAKITVEKGETLVHQARYMIFDNYTMATFRSKEDSAKDQVPLHYPQKCISAFDAMVHMIANRMYPELYTLGKLQASLCKLEEDINQMISDAKTYEDNQGMERIPDHEPQLRGFWRRLPSSLMKKQKSSYPYERARQNRVHKCKQRRVRDLLTSLNSLSAALFAAIAVAERQTVVLLDLRKMLLASCQTEATSKNHEERYPPHRSPSYKRVPGILTPLKYPEQEWRNILGTINEMVQERKSFIQKIKELVENMDIRGEILFGFLASTAKERVEDTPMQLVETQSFPGFLEVSLAFIPLNFCTSYYGMNLKEWDGNKPSKLDFLRLVSISFFGVSGIIFFAGAVFFAVHRVFSRFSKKNIYDIESQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5F8</accession>
    <name>A0A2T7A5F8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1061410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5F8"/>
    <dbReference type="STRING" id="42251.A0A2T7A5F8"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="3">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27156" checksum="6CCFDF4B6799C2EA" modified="2018-07-18" version="1">MTSRALGRKVHIYNAKDTTTVLGGIHLTTGMTKANLYSMVEIVFIFDNDYTLSSESGATIQRDDHPLKKGKYFINTAGSLRVNNEPWLFRTMSVGDQAPAKEFIHAVRERDYGWITIPGARGSISSVQNGMLLREDISTLFECYYLSINPDDGYKIVSFMGDENAGISGTCLDKTVLGNPERPVDQLLRWHFRQAVLANVRGEKGEPYNDPEASEWSVSDWGTMSGSKTGKNSISTLSLLAASSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5J4</accession>
    <name>A0A2T7A5J4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1119811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5J4"/>
    <dbReference type="STRING" id="42251.A0A2T7A5J4"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="31674" checksum="3B091CC244E2C9FA" modified="2018-07-18" version="1">MAGTYSGRRSGVNVSSYLENLNSIPVDEPLLDLQDDANLALFSNTSWFDFDMGQPLDDGTSDVLKGSKDFAALDQKPGDEQMDFMNDIDNSFGLPKFTLDDTLETQPTTDIVSPFTNDGAPSTGPVDSVMHSPSPNSPTAYSQLNGSTRTSAKRKGSAVSVAHTSPQTDSFEEASRLAAEEDKRRRNTAASARFRVKKKQREQALERSAKEMSEKVRHLEQKIVQLEMENKWLKNLIVEKKTPNGGKGVQDPSEDFAAKFSAAMKAGTLSGGPSANRSKDDADAMPEVNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5P1</accession>
    <name>A0A2T7A5P1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_233736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5P1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="163" mass="18739" checksum="E7E9F1833C2F2D97" modified="2018-07-18" version="1">MNKTNASPTHRSFPTFFALAQLCSRRCRCANDAQGRTVLTFSYPPSTSVTVEKEDINLEGYSFRSRQAEFLFLSDFTLLSTFSSFLGNLFVLGTFRLTYIYTIVPVCVHALAFRFLPCWQLFSFFPFLYTFFVFVWEICWLGVGGLDCVGGVSERLWLYNNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A694</accession>
    <name>A0A2T7A694_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_965388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A694"/>
    <dbReference type="OrthoDB" id="5398326at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20091" checksum="F2502AF34BDD12C1" modified="2018-07-18" version="1">MTPKSFTGGCQCSLLRYRILLPPPPSTVSITHCTSSNHPKTFTRTTLQISSSQIQLVSLATPPSPSPAATAQTLRVPEIPRAVYIPGVRPRRAGTEEQPPGYEDLEGERAGGVGWPYREFEYTGGIRGFCAHCGGVVLVWGCAGGGDGKVEIEMGSLDAPGEVFDCFFGRSGGVRACCSEREVSGVNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6I2</accession>
    <name>A0A2T7A6I2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1061120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6I2"/>
    <dbReference type="STRING" id="42251.A0A2T7A6I2"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001558">
        <property type="entry name" value="Ribosome biogenesis GTPase Lsg1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="180"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="612" mass="69023" checksum="AC6EF99417317BEF" modified="2018-07-18" version="1">MVLAESKNKVGLGRALMNSRSGSAHKTNNKHRGNGAGRDGRGTGSGQAETLYTTEKHEADWYKMRSITQQNDLDEFLNTAELADTDFTAEKTSNLKIIHKDQVNSYLLTADEEKAAKTKHRQNKQQLTVPRRPHWDSTTTPAELERREKDSFLHWRRGLAELQETKDLLMTPFERNLEVWRQLWRVIERSDLVVQIVDARNPLMFRSEDMERYVKEVDKRKNNLLLVNKADMMTAEQRSAWADYFEKEGISYRFFSAALAKQVNEEYYSEDEEEKPVEEVVEEEKEEPRIRILTVSELEEVFLEHAPIVEDKDPEKPRKTQIGLVGYPNVGKSSTINALIGAKKVSVSSTPGKTKHFQTLHLSEEIVLCDCPGLVFPNFATTKAELVCNGVLPIDQLREFSGPATLVAQRIPQHFLESLYGIKIHTRPFEEGGTGIPTGEELLMAYARARSFYKTGAGNPDESRAARYVLKDYVNGKLRFCHPPPADPPIDSFNFNKGIYDEAHLPQNRRAGASLDQDHDDDLASEDLPVVEMGEKSHDLDRKFFADGQGSLGHMKTPFHLGAGAAGALPGGKHLSGRKARTMIALDNNLSPEEVRKAMGGKKHFKGKKNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A724</accession>
    <name>A0A2T7A724_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1060923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000010">
        <property type="protein sequence ID" value="PUU83527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A724"/>
    <dbReference type="STRING" id="42251.A0A2T7A724"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="305" mass="34563" checksum="A999C6C36C132B7A" modified="2018-07-18" version="1">MDTKDGALRHTEPASITEITTEEVSECGLKNALRGIPAQQIHIFLKTWNVLEILDETSVWMNSLPCPYLAFLNTSPQQIIDFEAVQTPGIRKQYIESLQILIIKLPFKAQEVVTEHISYRLRRKAVLMGDVDEELGGTGSTTYRSTNTIFCNTCKEADAGIIPHQRRPGPHGWPTIIFESAVSESLERLHEDARWWLTQNNQEVHAVLLAHIFRAEQIIDLEVWRILPIKCEGASVGSDAQRMPQIDNQLRINCSTFPHTISGTVPFFVIGFKDLVLRDKTAGEEDFFLDFLDIQSIATLFRVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A755</accession>
    <name>A0A2T7A755_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1072075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A755"/>
    <dbReference type="STRING" id="42251.A0A2T7A755"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="13863" checksum="9739DECF121408A9" modified="2018-07-18" version="1">MAGKVLQDLTDQFQALSKDMSSIVEARQKLDSQLQENKSVQKEFASLADDTKIYKLIGPVLVKQDKSEAVMNVDKRLEFINSEIVRIEKQISDIQGKQERKKMEIIQVQTQLRQDAQAQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A785</accession>
    <name>A0A2T7A785_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_821350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A785"/>
    <dbReference type="STRING" id="42251.A0A2T7A785"/>
    <dbReference type="OrthoDB" id="2426521at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="21114" checksum="EE2BE15E3E87A92C" modified="2018-07-18" version="1">MHLLYRGFPDLVDDLPPEVGDRPGPKPALYVGSNIIDVLRYSEKLENTQGSDGQSSRYNEYGEARVILVRDEETCDKLQAELGRSSLVLTILESKGMEFEDVFLYDFLSTSPYSHKLNILEELFKRRHHTDLSSEDHLGPAGEGREGNERRVEGGARPESGHNPSAYQGGHADWIKENIVLCSELKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Q0</accession>
    <name>A0A2T7A7Q0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1072005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Q0"/>
    <dbReference type="STRING" id="42251.A0A2T7A7Q0"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU83735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="502" mass="58738" checksum="D88DB18F45B08104" modified="2018-07-18" version="1">MGILDEQRSLCEDLERLEQACADRILEEPKSTRERLTRDHQIAKFVGRFQQQSARLLETQADRDGTRQREIDSLSSKDPFEEFYRQLGQIKDFHRRYPNEPVENLERAYKRRQATDGEYVSEIDTMFTGEEAHGKFFDLTKNHEDYLNLPGVKRITYLSYLSLFDKFDKFARNQKMNDKYFKYVSALAEYLENFLSRTRPLENPEGIVEQTGEDFEKAWEEDNVPGWGKLEKGDGDIGPRQEEVRVPKEEFYCDVCAKGFKNNNVFDHHFNGKQHKKAAAKRAEGGAENGEVRKAEGSSGAASKLKDKAIAEREWRIVKLTEIMSKERDETMTNVERKQSLTERERQMELDALYEENSANPNLEAETHTDDENDDEKIYNPLKLPLAWDGKPIPYWLYKLHGLGVEFSCEICGNFVYMGRRAFDKHFNEYRHTYGLRCLGITNTTLFREITKIDEAQRLWEKLENDKKKTKMANETVEEMEDGQGNVMPRKVYEDLQKQGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A812</accession>
    <name>A0A2T7A812_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">beta-glucosidase</fullName>
            <ecNumber evidence="16">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1071767</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="16"/>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A812"/>
    <dbReference type="STRING" id="42251.A0A2T7A812"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF20">
        <property type="entry name" value="BETA-GLUCOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015775475" description="beta-glucosidase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="18">
        <location>
            <begin position="794"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU83842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="885" mass="94063" checksum="89FC3C18C5C9C8BE" modified="2018-07-18" version="1">MIAAIGVLALILGLVLGLPQANGGGINGSAEALEGATSPSWYPSPKGGTVDQWAESYRKAAALVRKMSLAEKVNITTGTGWPMGPCVGNTGTTNAGFPSLCLQDGPLGIRFADSITVFPAGITTAATWSRKLMYDRARALAKEAKGKGVNVLLGPCVGPLGRSPLAGRNWEGFGSDPYLQGIAGGLSVQGIQDEGVIATAKHFVANEQEKFRQLSESLSQGFKDVTSPLSSNIGDRALRELYIWPFMDTVRMGVGSVMCGYNQINNSIACQNSYILNGILKDELGFQGFVVSDWLAQRSGVASVLSGMDMTMPGDGLLWADGDSLLGPQLTRAVLNGSVPIDRLDDMALRIVATWYQLGQDDASYPRPNFSSWFRTSIGPTYAGVGPSAGHSLQNSYADVRDDHHEVARAIAAESITLLKNTNGALPLKSGKDAKKSIMIFGSDAGPNLLGPNGCPDRSCNNGTLGQGWGSGTAEYTYLVTPLEAIQAKALADRTMVEYVLDDYQYSAINSTAGKAPNATCLVFVSSDSGEGYASAEGVLGDRVDLKLWHGGDKLILSVAERCSNTIVVIHSVGPVDMEAWIEHKNVTAVLMAHLPGQESGTAVLDVLYGSVNPSGRLPYTIGKSLADYGPAAPILKQPGGPAPQQNFSEGLYIDYRHFDKQGITPRFEFGFGLSYTTFEFSDMVITQTLVPTEFPPARPIGVPAPELNSTIPPSSQLGFPLGMVRLPKYIYPYLSDTTVTKSSAPYPYPPGYSTTPHKPSPAGGAQGGHPALFDTIFHVTVSVFNTGSLPGKAVPQLYISYPNGTGIDFPVRSLRGFDKVAAGPGETVAVGFDITRRDLSYWDEKKGNWRIPLDKKGNIGAYEIFVGDSSRGNGVTGRTKVVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A894</accession>
    <name>A0A2T7A894_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1112118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A894"/>
    <dbReference type="STRING" id="42251.A0A2T7A894"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050276">
        <property type="entry name" value="MshD_Acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43617">
        <property type="entry name" value="L-AMINO ACID N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="274" mass="30564" checksum="C392F67EAEF0FB0A" modified="2018-07-18" version="1">MAVIIREYQEGDFGDVVEICKLTAHPSIQSSADILPYIYAVPYIRLEPAHAFVLDAGSSEENASGSGSGSGRRVVGYIIGTPDTKTFVERYRREYLPTLTLPSAVANITATSVAAQVDDGDGDGDELQRMFEKILLNPEEMLQPAAPDFIPCYPAHLHIDILPEFQGKGFGGRLMEKFLRGMRQSGGGACGGVHLGMRRDNVAAGRFYKRCGFRVHEGLSDEHTTWMVKDLEDLEGEEGEREDLHDTRNIAREKVDRLYQVFPRMITTYQQMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8A4</accession>
    <name>A0A2T7A8A4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1060546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8A4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="13404" checksum="2EFD99AE9E241448" modified="2018-07-18" version="1">MTSEGCRYSRTAQLKRMGRKKSKESLFRETTPGRIGRIGSIFPALLYSATVAPGDQTGKQEFARKAKRFSPELSPSVKFHGAGVKWATLLPWQPPKSLTNCCQLSGKQQTAQFKVLSGVDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8K0</accession>
    <name>A0A2T7A8K0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1118357</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8K0"/>
    <dbReference type="STRING" id="42251.A0A2T7A8K0"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="67"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="255"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU84050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="615" mass="68688" checksum="593C08AE584ACC71" modified="2018-07-18" version="1">MAKRKHRDEEDPAPAITTTTTTTTTAITTTEVDANASFATFGLDPRLLQGIAKQNFSHPTLVQAKAIPLALEGRDILARAKTGSGKTAAYLLPVLQAILKRKETSEEKFTSALILVPTRELAQQVHKVIESLAAYCGKHVRSINLAQNISEKVQQSLLSEKQDIIVSTPSRALVHINVSKSLTSQLTHLVIDEADLVLSYGYEDDLQGVSKALPKGLQTLLMSATLTTEVETLKSLFCRNPAILRLEDVDAEGEGLTQYCVKCSEDEKFLLLYVIFKLKLIKGKTIIFVGDIDRSYRVKLFLEQFGIRSCVLNSELPVNSRLHIVEEFNKNVYEIVIASDENEVLGDEEDDDGNSIPTPKPTTSQEQAESEPTSKPKKRKKARNRKDKEYGISRGLDFNNLACVLNFDLPTTSKSYTHRIGRTARAHKNGISLSFVIPTHLFSKHKPTTHPTCANDERTLQRIRKSQTKLGREIKPYAFDMAQVDAFRYRMDDALRAVTKVAVREARMRELRVELMKSERLKRHFEENPGDLLALRHDGESGQVRVQAHLRHVPEYLLPKGGKSGMLKPAGGAVGHVGLRKVRENRIRKARQKKTGRGAAGTGRDPVKMYRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8P1</accession>
    <name>A0A2T7A8P1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NUDE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_961553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8P1"/>
    <dbReference type="STRING" id="42251.A0A2T7A8P1"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="129"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="395"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU84106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="524" mass="57944" checksum="4DB26801628A918B" modified="2018-07-18" version="1">MPSKDCDSPESEAKEALAYYKSQIQQLESELTDFQASSKELEQELEKELEASEKQHRDLRNKNEGLRYEVEEWKNKYKQSKTEANTAQNVLQKEITNLRETNRQISLRLRDIEVSNDDFERQERIVKSSLEDLESKYNQAIERGVLLEEEIKIGEQEREGLRIECQRLRDELSDLKVEQDITVDKLNNAMAMAAKYGNGSLHHVPPPVKFQSTLSETSSVASRPPSTPTTPSIASTSTPQSDHSPTPPSPPMSEVSTTPSQSSRAREDPALTPRPRHHQRPARSRAPSFGSQGPGMGLHIPSSKSLHHIRGLIGQMQRLEQRVQNARSKLPGPVNTPPRISPRNQGTFIPPTITMRSQKKHRASSTASSITSGGSDRDTVYPHSTRLSFGERPSSRTTSRPSSRASGATSRSSLGSQLPQSQRPSSRASLSGRVTPMETHSEFGMTTISMRDRTSIGSVASSTEDTFPAPAIRRNTVAKGESGIPLPASGLPRRSFGGRRISSNSVDEEARRRLGRKLSGVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8S2</accession>
    <name>A0A2T7A8S2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1070657</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8S2"/>
    <dbReference type="STRING" id="42251.A0A2T7A8S2"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="8">
        <location>
            <begin position="617"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="576"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU84136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="725" mass="80732" checksum="27A7C74C67523C8A" modified="2018-07-18" version="1">MPWTSTTEDFDPDKAPAMSLLPELLLTVLFGAQASFTHPGIILPPKELLGDSELKAIIKRTQKSRDAREVLGFSPRIWEALTETLRAGNDQLATNKYNLVPRVRDLVILARNLLATKEKAQNYASDEGFEAEVRRLLDICVDKASKPIAANIDKQTHETEMHIKGNYKKVMITTLQFLNNLMSQNETRKLHVWLHMFGTPAASAPSSSVAPTKGSQKSKGKNSQAGKPSSGSGVGIVGSGALGAMHPHKETVAKCNFLSAGFNAKYYKPGFLTEVPRLLQPDELQPLPMILQNGVVPLEGTDHAMQAVRCKLMLAQGYGRSLLREIFVFLGAWEVDEEDFCFRMMAQVTEAILLNGLIPYAYESFRDEKDIVTPAQSVLLKLLASVYRQPESGRDHSANSSVHSFSISPPSMSSGSSASPITDFGEAFDPPPIIESSIPTFFVAVLRKQVIPPTIAIIKLQGAIREGKTKKETFELSLWDLDRVYEGLYQFFELLVLFSEDEEAKRVLVSSDKGIVGDLVIFLKELDKAIPRWVASKSIPQPLSPSPSSPQEKEAGKEELDEVLKVNEAYRVERPFDVYPGDNDEEGSGDESEDRDDEEPNDDRGLSEPEEFTWPHIKRYLVMLLSSFSWQNKTVQDLVREKGGLQAVLNQCMIDDDNPYIREHAILCIRNLLEGNPENQQVVKELEAVQAIPNEVLDRHGYEHYIDDAGRVQLRKVKGKGVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A981</accession>
    <name>A0A2T7A981_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A981"/>
    <dbReference type="OrthoDB" id="5421906at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="295" mass="33455" checksum="E5FCE977FA73ACEB" modified="2018-07-18" version="1">MSSFTQSSEAQGSAPTRRRIYLTDEKKLMLVRLCVENQADFQDRRKGQFWAMISDLLHQEVGIFLKDPAGTVKGLVASRRTQLKVQGRESGTVQEDTDFTQAVDRWIEVEEEREHAKELARQPKTQSAREAQEAEVHRSNLLRSAHLKRHLSSESSDGGNDDKSGPKRSRQGSGDSEKEIEDLGNPEERAVSTNTIQRISSMRKKTRERAVREDTHEMITAVKGMGDAVALVAEKLGRQGEGSSRFLNMEQRLNTIEENIRQEGDLRQKQAERVEQQQEKTNQLLEGILSKIKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9G9</accession>
    <name>A0A2T6Z9G9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_919690</name>
        <name evidence="1" type="ORF">B9Z19DRAFT_931466</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000789">
        <property type="protein sequence ID" value="PUU72133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000192">
        <property type="protein sequence ID" value="PUU76318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9G9"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9G9"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="22926" checksum="10F18EB38690F73F" modified="2018-07-18" version="1" fragment="single">LLCGISSESQTPPTLELPIPDLSIATTTTYDIDSFIAKVKCLSVASKGVRVQFTPSSQKNISSDVHLFSKIEERLASGKVHVRQVPLHHIPHFYLGHLTSSLYLPLYVFLPGLWQKNLGTNSYVANQHLQQWMDIGFIPSILQHCPPDIVQHLPLSFASASMNTFARGRELGIQNREVYGAKRQELHYFLSGRYLKPIWQDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA09</accession>
    <name>A0A2T6ZA09_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1137956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000569">
        <property type="protein sequence ID" value="PUU72332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA09"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA09"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="206"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="477" mass="52198" checksum="5F9E1E8BF0E07D42" modified="2018-07-18" version="1">MPIASGSTPTCSTSTQSAEADEYFRPGVVRSLSYRSTTRSLRSPFPPGVVGAVGGEVAEGAADSQATIAPANIPAVSTGDSCSQHAPSTNQSPVPSLSSTGSTGAPAATLGLGVSARASMNLSPSPSFNTGGHKTVVPEGEDPHIQQRDRTDHHSHHSHIHPHPHSHHHHGHDPKTGFYNATTSTFSWSTCNHDPDPHYERLVFDYRVISQSMHAYRHISIFRRFGRLSMANLLYYQDELAEIEKALGEVDREETRWMQTGSESENAVVDLKERRFKLMRMLRETLKNYYEALLLQEQVFTSLDPPRPVDSNLLSALEDPSTPPRTLTDPFYKNTDDLVALGLGGRDSLEKLVGRIIPRIFPHRNPSVEDVRQRNMSQRDIASIFSPFTRRITRMVIALATALLMLGPMIILQFLKSDLWKLVCISIFTMMLAVLVALGTRGRGEAIVMVIAAYSAVLVVFVQGNGGCSEGGSCSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAC9</accession>
    <name>A0A2T6ZAC9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA pol II accessory factor, Cdc73 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_676267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000533">
        <property type="protein sequence ID" value="PUU72450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAC9"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="309"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="470" mass="51066" checksum="66DB788852081E78" modified="2018-07-18" version="1">MAESDTLLRVSVSRPDTTMSSSSPTADTDPLSLLRLSISQSSSPSLSHTPNPPPQGASPVTLASASYLIFPSAAFPLWTKTRFQKSGGESVDLRSIYFAWLHREDTIPDYITKAQNLGDGVVTNLAFLERLELVTWLEGGQEESDFIKPLASAVTSALASADSHTVGGAPGGGVAGAVAMGGQGVQSTPGGSAKIGGSSAALTGKVRVTDPRLLEIYSYERVLSNRNTFLRGIKPTDFSHVRKQAEDFITRLRNQKPSGSNPSSSTPGPHHHHPHHPQQKSLPHRSSHPASGSASATSTPSKSPSKSRSRDPIILLSPSASSLLTMANIKAFLENGSFIPASQLPGPHETIHQISRLIPAIHPTAPVRFLVVDSIEKFKPDYWDRVVGVFTTGQAWQFRDYKWNNPVELFRQVRGFYVGWDGETVPDQVRGWGAGVKCLNIERNRRFRDREVCESIWDGIETGMKLKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAL6</accession>
    <name>A0A2T6ZAL6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_660542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000517">
        <property type="protein sequence ID" value="PUU72513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAL6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAL6"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="127" mass="13884" checksum="0D99D0E95AC6799B" modified="2018-07-18" version="1">MNDANECQILITVLDILQIMLMSPSNARSWTPRVKQIIFDEVHSIGNAEDGLVWEQLLLLSPCPIIALSATVGNPEEFGSWLASTQRSIDSEERNGLIRGDALESFKVQPVGYGRSHAGYSSCCGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBA2</accession>
    <name>A0A2T6ZBA2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1136787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000471">
        <property type="protein sequence ID" value="PUU72749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBA2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBA2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="316" mass="35506" checksum="4E921137034100F5" modified="2018-07-18" version="1">MGIQTGGGMLLLSRETRLESILAIEAPHIASCEILLETPADLLPAPLLTYHNDLSPIESYGYLLRQQRHRPTQAHLHLPGRHDPLGNFRRIHYFTGRVQAGRDRSQSLPGFPSDGRGKAVVARGGEASGGIAAVIKKEVESMPKHWTNIVAKHWTNFEDLNPPFHEKRNSLHVEHTPASSRVKHEPSSSKLIQESSDLSLPPTLMLRIRPATSPHSHIPSTTLSISRTALVHHYNEQGCTEAGIHQWEYVYRMRSLKVARMYPNRVHTLGKIKAIRPTGRRPEAKVDLHNISRESAYRTRFEKPFSKSAVGSSKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCS1</accession>
    <name>A0A2T6ZCS1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000390">
        <property type="protein sequence ID" value="PUU73295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCS1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCS1"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="11718" checksum="50343B8ABA8091A8" modified="2018-07-18" version="1">MLPERRPITTFEGEHIHAGTGEPLTSGRRMRSQRDWGNADERAVSNSSDEDETMEDGGKIVPDDRIAGNLSGLAAAIGTSLAPINIPHIPGTASPLSNIGDISESGRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD13</accession>
    <name>A0A2T6ZD13_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000380">
        <property type="protein sequence ID" value="PUU73391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD13"/>
    <dbReference type="OrthoDB" id="5356990at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="237" mass="26406" checksum="4E74AE0E1A60663B" modified="2018-07-18" version="1">MSRIHSTHKKALRALEPIANLLCQSHRHEMSIIDPASGKIVEGYSLTIECGGDSIIWTVKMGENCRFGSLMRAREGLARRSVPRTPQLHSIGRLKKSWLKYPMILRNDQHTSNINHLPSANGPQIGTGDTDPGHREPGGVVYVVCCPLSTGLSSDLFSEVSRPPSSPFDTEGEDADEYENRYDTESKSEGEDEESNTDGGEGPRDKGDEDEDEGDDQDWSEWEGPWRQRDHSSSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD80</accession>
    <name>A0A2T6ZD80_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000385">
        <property type="protein sequence ID" value="PUU73364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD80"/>
    <dbReference type="OrthoDB" id="5388200at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="146" mass="16155" checksum="EEA557BC6BF4F715" modified="2018-07-18" version="1">MASYSPNRERQRSSGVLWVVPGSAPPPPPPPQWDSQGQSRGRRNTAEWDQDPMDVDCDGGDGHDERVERELVRGLVAKDVFSWVNSTDAENDQIFSVTSRSGGKNICDASGSDTAPTSPLSGNFPEQLEFRRRRLEEAARENVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDJ2</accession>
    <name>A0A2T6ZDJ2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000368">
        <property type="protein sequence ID" value="PUU73560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDJ2"/>
    <dbReference type="OrthoDB" id="5421241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Cleavage and polyadenylation specificity factor 2 C-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Cleavage and polyadenylation specificity factor 2 C-terminal" evidence="2">
        <location>
            <begin position="160"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="274" mass="29322" checksum="D8976A1E20C57566" modified="2018-07-18" version="1">MLKEGDRVILDGKKVLSKSPETRSREGRSQVEQKSALVLDVLPPALGVSTRSVAQLIYVDDIRLADLQRVLLDDGLMAEFREEGALLIDGVVVVQKGGVGGVIIQDGGGGMLRRAAQNGKGFCGKLEGGYLKASQWFLEFVSGHHRRSGISANSVILDGKKVKLPKSPGAESKEGGSEVEQKSYLVLDELPCALAVSIRSVAQPIHVDDIKLVDLRRVLLDDGLTAKFRGEETLLIDGVIVVRRGGGVGSVIIEDGGGAMLRRAARNSRAFCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDJ3</accession>
    <name>A0A2T6ZDJ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1004142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000368">
        <property type="protein sequence ID" value="PUU73567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDJ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDJ3"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="49"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="516"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU73567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="645" mass="72831" checksum="1449E8CADEDF858B" modified="2018-07-18" version="1">MATESTTPPVKGVPPAPSIESLNEQLSNFGISEPLTLFPDSNPTTNPIDVYRCYIADVLAPITGVDIKLVYPALEWTQNLEKGDLILAAPRLRIPGKNPSELTKEWAEKFPENPYVLPPTAAGTFLQFYFKKDVLSKLVLSSILGRKSAYGPIDTGRGKRIIVEFSSPNIAKPFHAGHLRSTIIGGFLSNLYESCGWEVIRMNYLGDWGKQFGILGVGYKRFGSEEKLLADPINHLFEVYVAINKIVEQEKEVEKAKAAEMGEKQISNGPTDQEALDFFFQMEHGSEECIAMWKRFRELSIEKYKATYSRLNISYDDYSGESQVSKESMERAGKMMKEMGISSESDGAIVVDFKPHAKKLGKAVVQKKDGTTLYLTRDIGAAMERYEKYKFDKMIYVVACQQDLHLQQLFMILKLLKLDWADRLTHVNFGMVLGMSSRRGTVVFLDDILADARDKMHEVMRKNEEKYKQVEDPEMVADVVGRTAVMIQDMSGKRINNYTFDMARMTSFEGDTGPYLQYAHSRLCSIQRKAGIPAEELLNADFSLLTEDHATNLIRCLAQYPDVLQNTLKTLEPTTVVTYLFKMTHLLSSSYDVLRVVGEEPKLSAARMALYESARQVLNNGMRLLGLTPVERYVFPYVFLSRGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE65</accession>
    <name>A0A2T6ZE65_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1094368</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE65"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE65"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000231">
        <property type="entry name" value="mRNA cap guanine-N7 methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="15">
        <location>
            <begin position="313"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU73783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="655" mass="74247" checksum="9E9A58C87757412F" modified="2018-07-18" version="1">MYDSARDCFTEQQQQERREQQDRERQRQQQASPAGPADADTPPRRRISTVGDLLGPVESKNEALKGSAGTKTSSDKKEGGSPEASSETMSPETPLKDIKNTGIPKTSTDTTTPTATTTHSEAKMDGNAPASSSATKRRRVSSSSPGKRRQRVSNERDGDASNPTTSRTDDRRPTSDDPQGARGNAYASRRYSRSPTQRQPYQRRPTSPGGRYRYKSPPPPLIPKRDPSPTLPPGEDGSRSRDASPPWKRKRPGQASRFSEKEKAETRERLRKMEEEVERKAKEAIKERGVEEVVKAHYNDKRELGKTWRKTDSRIKGLRSFNNWIKSTIVQKFSPNDDFDPRNHPRDSSSHLVVLDMGCGKGGDLLKWKSAPQEVGFYVGVDTADVSIQHARERYDSMIRDSRRRQGGRRDRNGHQIFQAEFHVMDCWTRWVGEIPIVSKVGVDPNVGPGQSTRMSARWGSGGGFDVVSMMFCMHYAFESEQKCRNMLRNVSGALKKGGRFIGTIPSSDVISARVQGKHMPADSPEKEKLDKSEHGLQEWGNSIYRVRFAEEPPKAGVFRPPWGWRYSFFLEEAVEEVPEYVVPWEAFRAIAEDYSLELIYKKPFHDIWREEKDDKDLRSLSERMGVRDREGKFALGDEEWEACGFYLGFAFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEV1</accession>
    <name>A0A2T6ZEV1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000327">
        <property type="protein sequence ID" value="PUU74028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEV1"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38839" checksum="3552F01CC6CC56C2" modified="2018-07-18" version="1">MATSLSLPALSSLLDTTDFSKTVTPFLHQLSISHIQPLLTGQVPVKEWYLSTNPLITTVHFALAVTLAVLVISEINRNYSQIDRLWSLLPTIYIGHYTLFAHMNGLDTQRLDTLTAFSLLWSIRLTYNYWRRGGYNIGSEDYRWEIVQKGVPRWGFILLNIVFISFIQSALLCMIAAPAYLHLLASTLPITPTWSLTDLVLSRGLLLALLVETFADQQQWVYQSAKAAYRTTGVVPRGYTKADLDRGFVVTGLWSFCRHPNYTAEQAIWVLVYQWSCLVSGELWNWTGLGAIGYLALFQASVRLTENITAEKYKEYKEYQKMVNKFVPGLGALTGASEFEKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEV2</accession>
    <name>A0A2T6ZEV2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000328">
        <property type="protein sequence ID" value="PUU74002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEV2"/>
    <dbReference type="OrthoDB" id="5418189at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="19164" checksum="AECF0662C77FB6A6" modified="2018-07-18" version="1">MSASQTPTPTPPEAQEILRDIADLLCPAHKHNISAPRIMPGLPTHYSMVIGCPQEGDIKWQVGMSADFLAKVIRRCKVLSDSPLGHVDVTTLAPLSVWEGDQCNDILWLLDIGHLKEGWWEDNPSRLSDQRKDYKYGFSFPYFLHWFFPPLVSQQLDGMKKRLRVCVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGB9</accession>
    <name>A0A2T6ZGB9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_435424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000294">
        <property type="protein sequence ID" value="PUU74522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGB9"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33134" checksum="C6941FD4AADFBDD3" modified="2018-07-18" version="1">MEHNHSGCSAQSSRQNSPPTWVKLKLRANRSRGGRCPPGMMNPFTRKTRAEKPRGRGAGEKAKERKVSRFNHASDYKKHKNQRHLRPFLCVFFFAGRNQKFGNKNEWKRHVNSQYLQLFYRHCYDSLCADRKAIFNRKDLFGQHLKRMHPPPAGSKSSAASGDRTLPRRAPTAAAGEQVRYCERNFEGPQGWEQRMEHVGQHYQKNYKEFSNDCWVPDEGLIKWALEHGIIEDNNDGGYTIISTGKDAIVKAGVEQKKLAREGMARMGYAEDGDLDFDAESEDEYMHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGC9</accession>
    <name>A0A2T6ZGC9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1133240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGC9"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="247" mass="26952" checksum="2E58F4FAE6CAA54C" modified="2018-07-18" version="1">MEPLPKLTEGRSVISSYPDLLSTLTDFLTVCIHTILYHRNIYPPELYIKARKYSFPVYQSRHERVCKWIADAVGAVAGEIAKGNVSKVSLIIISPRNIPLERYVFDLSAFPNVPFEGGYGDLLLQQLAEVGGGVGGEEKKRLDEITIAGLEAQFRACLMKLSVAAPDLGRLPEDCTYTVAMEMKEPGAPINYAEVWVPAEGQGSDGTGIRHGGGTRSTAIRTVEAGSICLELSIEETTTKTKMVFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGI4</accession>
    <name>A0A2T6ZGI4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1068079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="NESQ01000288">
        <property type="protein sequence ID" value="PUU74611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGI4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGI4"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="199"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="471" mass="52867" checksum="BCF12F59AE9B7BEE" modified="2018-07-18" version="1">MSNKPPHGTEEVEGIASLVDTDLYKLTMQCAVLKNYPDVDVTYAYTNRTFDLKLSREGFEWIKAQVAKLGQLRLSQAELEFLQRACPYLPQTYLAYLEKFSFKPDDQLVLAFTPDTGVSDRMANEGNENSEKVEFADGSAKGDVRIDIKGKWVETILYEIPLLVLVSQAYFKFSNTDWNYEGQEEKAFAKGLQLLESGCALSEFGTRRRRSYHTQELVLNGLVRATAHYEKSGGGEGKLLGTSNVHFAHRMGLNPIGTVAHEWFMGIAAITNDYTRANEIGLRQWIDCFGEGVLSIALTDTFGTPHFLRNFALKYPPSGKSYAEIFAGVRQDSGDPEEFVKRMRKFYDEQGIKSKKTIVFSDSLDVDLCLKYKELAEREGFVSSFGVGTFLTTANPSDDFVQLSSPGQRSWPLNIVVKVNSANGKPAVKISDNISKNTGDRATVERVKQELGYVEREWEDGNERDRSGSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGP8</accession>
    <name>A0A2T6ZGP8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1110520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000280">
        <property type="protein sequence ID" value="PUU74668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGP8"/>
    <dbReference type="OrthoDB" id="5305647at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21617" checksum="EF8DF3B77605E1DE" modified="2018-07-18" version="1" fragment="single">MDHVTQSYRSVAATVNPVIGGPSTPLALQEFSLISFDNSGYRQPLPPGLGDLPLYPDDDGYFSINGSLDSTDFSPQTTLASISHDNQSTFNPMITDILGFPAESPHVTPDPHSAHLNADTVCSGSRARSESRRYCCREPGCTWRSSFPTKQALDRHHEVKHLDKHVDCPIPGCERVGDKGIKRKDNLPAHIWNKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGT7</accession>
    <name>A0A2T6ZGT7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_410404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGT7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="11586" checksum="8CFD4127AB1508B5" modified="2018-07-18" version="1">MFRPILRPMLNQSVFRPALLGKVIRPALVLPISPRPVPAPVVLFARRGSSMFLLPNTNLIVLTPPSPPPKWMTAALLKSSPRSMGSFNQLRMISKWLVTSTSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGV3</accession>
    <name>A0A2T6ZGV3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1132779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGV3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGV3"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="55"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="283"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="369" mass="40785" checksum="8B54F732BCA9CFD8" modified="2018-07-18" version="1">MSTTVEKIKAIEDEMAKTQKNKATSFHLGQLKAKLAKLRRELVTPSSSGGGAGRFPSVGKSTLLNLLTGTHSEAAAYEFTTLTTVPGCVMYNGAKIQMLDLPGIIQGAKDGKGRGRQVIAVAKQCNLIFIVLDVNKPLTDKKIIEQELEGFGIRINKQPPNIVFRKKDKGGINVTSTVPLTHLDAEEIRAVTTEYKISSADIAFRCDATVDDLIDVIEEKSRRYIPVIYALNKIDAISIEELDLLYRIPNSVPISSERFMADAVEPQGWNVDELLELMWEKLDLRRVYTKPKGQTPDYTQPVVLRSNACTVEDFCKAIHKSIIDSFKIAIVYGSSVKHQPQRVGLSHVLEDEDVVGAIAFVESFGSQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH10</accession>
    <name>A0A2T6ZH10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1067954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH10"/>
    <dbReference type="OrthoDB" id="5359682at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="447" mass="49500" checksum="1DF34C9AF31A7D09" modified="2018-07-18" version="1">MDPLTPAITPGTASPASMVPAENHVYFPQNQSPVPARSLLTISVCSVASESSCIPVARCPHCLEAIKLTDIEKSGLSVSSDDQKRIDDAGYLLGEGPHVDSATRTLLKTLQETDRDLKRIGQDLHQIHLLNPTPASSRTPSAQSLFALAKEQEKRPPPPGNSSLHPNNGAMSPSHRSEVASPFGPTSSSSSPTEPQLRSAAVGFQSGHPLIRDFGDLENLSQANIRLLKTLQDKVNKVDTMEKLLKTEREALDRERENVMQMKAEIDRERLRLMDRGLYWRSYGAQSSVTMSRGDSAGTTVDEWLKGEDGEAAVYEEWSEEKEQEMLMLEEKLRKAQMGWSDEQEEILGPLEKLREEKRHQAKAKRLERQTSIKFDRILSSDEKTEKGPSHKKSVDRSGSPTGSATRHSKNPFTNLVRKGSVGSVIPRRASSASTAITTPKLFKKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHK3</accession>
    <name>A0A2T6ZHK3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1132159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHK3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHK3"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="535" mass="58835" checksum="E90B5591ED461026" modified="2018-07-18" version="1">MASSNMTGDSRQLPISDLEAKHYYHGLYSKPLLIARTGSNAWVVPSGPEAYLRPKELGAVTDAVLSEAWEGGLAFGIHEILEANAVRWTSTDVVRIGFVGECAAPVVVWIGVIPDTLSHEDGQIAAKACKELLAVRNIHDIEVEIREANVFRYISPKLKKPAFSVHPTAQIIQPLTPTSGLFICNSRTPELEGTGGFFVSDQSSLYLVTARHVLFHTDHTNNHSYKWKSPNEPINIALFGTCGFKKYLTQIEHAITIENITLELHGNRIKAMREQRDMVEAEEFELELADAAKQIKEAVDTIVTLEKLLKDVKKVWGDIANRILGRVEFSPPIKLLTGVKKFTQDFALIKIDHSTMEVSGFPGNVLDLGTEIPAAQFTIMMFPNSKNKRNFSFPPDRLLKVNQIIPDTEMRNLPMYDDNDKKCLIVLKRGYGTGLTIGRSSGIKSFTRSYFPDRPPKVSKEWTILPYDNKSGPFAGPGDSGAAIIDCLGRLGGLITGGSGVSDSGPIVYATPVSFILEGLKANGYNVTIEATLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHW0</accession>
    <name>A0A2T6ZHW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1155236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHW0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHW0"/>
    <dbReference type="OrthoDB" id="4297048at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="596" mass="66732" checksum="822EDAC864F6B9B5" modified="2018-07-18" version="1">MFNLFGGSKRPNTQIPFTLYKQHAQPMPPCPLKPDAWEKALEKYSDKTYTKSLVGMLRYGALIGYTRPRAGQTLHRNHGSAREQPELLEQDLREQLRNKRLTCYKEGHLPPFFVSSPIGLVDKNDGNKRRIHDLSYPEGTGVNGGIHPERTKVVFSTLQDIMNIMKEDQCSVVAGIRENKAISISDEAREELEWWKNVLPTSPHIKILPSNRKTIEVFTSASGFKGMGGFYLKDKQDLKSLPVEQYFMKPHAESNVREKDPFPREMLAVEEALTMWSSVFRGFRVVFNTSNQGVAFGLLNHAVHSNGPPLDTLKRILLLGQKHDVDIWSHWIPNDDNELAICLSRFDRPRIHALAPKLSGLGGSRATRSDSRFSPSESKFSPSESKFSSPESKFSPSESRFSPSESKFSSSESKFSPSESKPSPSEGRFSHSKSRFPPSESRFSPSESGYSASESRFAPSEDRPTPPEGTKQIGNKPSGYRQRQTPASRNSSYAPPKTDPPLSPPPSPPPPPYKRTPSPPPATKPRAQRRKPRKAVLASESEAGEGSDALEQKKDGGLKSRTIILEFLSLLFWCAYVLCRWIGVALWKLVRLISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI59</accession>
    <name>A0A2T6ZI59_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI59"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="11964" checksum="5ACFE6944567739C" modified="2018-07-18" version="1">MATNVSSGSGGGGEEETLTQTQKEILVELRKSLGTLRVINEILVKTIAVAGGTGGDDSLGGSSGDNGGGGGGLVEAQKEVAREVRRVIGSAVWKGGGDEGEGGSADLPVGAVAEGSKDEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIC1</accession>
    <name>A0A2T6ZIC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIC1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="252" mass="27999" checksum="F1898A0659CE8D0D" modified="2018-07-18" version="1">MVFGLNTIPKHLPDMILRWAQYLPQISARSDNPQQITKDTTEEAYLRIYIQNTPASDIKPRQIYFEIQSHDNGNIRPSQRDGPYGKSDTFFEVGVYFALTRRTQRIPLQKNFHSSRCLRTHKVIWDIHGTDLIVSNMIKALMPGDELRVFAKCSGDNINYIESIEGQISASSAWADSQQDGPSGGVNEKLAATHYCHANGVTTPDGAPINGGQPATSGNLHSEKPPTVIATTLSPPKKRAFRNMFCCCFSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ14</accession>
    <name>A0A2T6ZJ14_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1067391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ14"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="672" mass="73996" checksum="C72B2FF8C5DDEC92" modified="2018-07-18" version="1">MDYDCTYVYAGPPDAISKQRGDKRQSRIRTSFFGGGNKRGSPSRMMVDKGDQEAVSFTFGRQKLRKASSKVSLRSMSSMTIHESPDEKSGYRSLSEILRGGRMPYAQRKGFTPISNPFNFSHITHANSQDFNRLHKAPEQELVRDFNKVVRDSSLPLRRRGTGDSDESSLPSPMSSCPVSNRSRSSSFQTIASRRRANSTKSISPSESLCELSQVRSEESSRYACPLTPPLRTSSRHCLRSLPESPSEGVLDDDTTLVNISDDISERTLPHAVTTPDNSSYGRKSPGIEKLMGDVSDGLTPAQQDRMELRGCKSTPDLTHIRQRSFLTVRTRPISQLSQASDTLNGSFIIPASPSQSICARRASKRLSMLMCASEGFTSEFGACLDSWEEDIDWCYENQVDADCDFVWDQNSECGAQAVDNVEEAIDLSMSMRDSTSLLSEVPKFPEPKEQFVFVDKRITGTFEDKLLLPPTPRLPPSPGFPPFEATPVSNIGAVDGGFSAYEPDNEAIIFRAADTALRHRSLSASASLPDLAPCRVHRDELTRVARKLDEHIAALNHEIAPHVTEHPAFHPFVVSHSLSTSYPPSRSRADSEATCVTLCSDTETVTPTDSIEVITPSSSAHNSVNFNSQYLEGRAEKGLSFAAAALPGVVEFGPELTHTIPIEEEGLIHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJC9</accession>
    <name>A0A2T6ZJC9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1131086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000224">
        <property type="protein sequence ID" value="PUU75583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJC9"/>
    <dbReference type="OrthoDB" id="2414008at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015624320" description="GPI anchored serine-threonine rich protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="27265" checksum="663C2399B24467F9" modified="2018-07-18" version="1">MKNSAQLYLYLLAVLMVGQSLAANMTPHLFVRRAHVISGPEASGLEKRKIACPITDFMCPGGGYCCPFGTTCEPGAMCGGASCGVGSTPCGDSCCNAGFACQGPNKPCLKTIGGGSIPTIPGNTIVSSSTLTIPGNTIVSSSTSTIPGNTLISSSTPTIPGNTLVSSSTSTIPGNTLVSSSTTTIPTTKAVTSGTTILNTYTIPIKPTSTIANSVPTPPSMTPGGYSSNSTAPPNANSSSIAIIPIGGGNSLKPGAWLGALGAVFFFAFFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJE4</accession>
    <name>A0A2T6ZJE4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1067286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000222">
        <property type="protein sequence ID" value="PUU75611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJE4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJE4"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="143"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40492" checksum="C17C3CC6ED239481" modified="2018-07-18" version="1">MSPRKIAVIGYGFSAKIFHIPFIQHNSKLTLSVIIQRNPTPGNDAAKDHSDVKVYRSTEEFYKTDSECELIVITTSNDTHVQYCKEAIENGRNVIVEKPLTIYSADAKELVNLAKKKGVGISVYQNRRFDSDFLTLTKVLPKVGELVSLETHFDRYKPDPTLDTSKSWKSAQVPGNGTLFDLGVHLLDQVVHLFGMPQRLFGDVRDERGCSTNPSATWGQEGFVDDFFTATLYYSSAPPRKRPFTVRVEASSLSCQTPQLRFVLRGMDGSWTKHNLDSQEAQLKAGRMPGTGGFGVEEEEHFGKLELKDGSVERTVAAVGDYGRFYKEIAEGGAAVPAEEAVRVIRLVELIGESSRLGKVLDIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJL5</accession>
    <name>A0A2T6ZJL5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-conjugating enzyme E2-18 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1102801</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000218">
        <property type="protein sequence ID" value="PUU75688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJL5"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU75688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="18091" checksum="C1BDE05FA7963D4E" modified="2018-07-18" version="1">MSLCVNRLQEERKQWRKDHPFGFYAKPAKTPQGGLDLMKWSCGIPGKEKTMWEGGLFKLDMIFPEEYPTKPPKCKFVPPLFHPNVYPSGTVCLSILNEDEDWKPAITIKQILLGIQDLLDDPNPESPAQADAYNLFRKDRPAYEKKIKYIVRENPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJR4</accession>
    <name>A0A2T6ZJR4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1089693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJR4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJR4"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="533" mass="59158" checksum="9714C8E883157C17" modified="2018-07-18" version="1">MRICEHDQHIRGFPPPWFWQIAIWAASPAAWQRNSPKSNASPPLPPMTDLMTPDGRMSFTLHSPPRSPSPPSPHHSPSTPSTFSALEVVPSPLSSPSYIMERLREWWKPTYEPLEDQDEREDASSPKAQRVSRFEYFVFLSLGVAMLWSWNMFMACATYFQRRFAENEFLLNNFQSLILVVSTITNLGSAVYLSCRQKSANYPWRICASLVINCTVFTVLALSAVMFRVGPEAYITVLLICVLWASWSAGLSQNGIYAFANKFGGIYTQAIMTGQGVAGVLPAIALEIVSVLAVPQSPGTQGSTASPKSAFIYFLTATFVSGSCLLLFLLLLSHHRISPHKSGSDVIDSDHAPAIHTQVSLWVLLKKLKFLSFAVWQCFLVTMTFPVYTQVILSVRPEDTSPRMFKPDVFIPIGFMLWNLGDLSGRVLCGWRRFTCDRPKLLALVSIARLVYIPLYTMCNIKGHGAVISSDLFYWLVQFTFGMSNGWVGSNVMMSTPGWVGDDEKEASGGFMGMCLVAGLATGSFASFLIVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKG7</accession>
    <name>A0A2T6ZKG7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_294255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKG7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKG7"/>
    <dbReference type="OrthoDB" id="5422260at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="477"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="873" mass="98151" checksum="B3E70840861453A6" modified="2018-07-18" version="1">MSGWRGRARERSRESSRQYHHSGEREREREYDRGHSGGDEQRTARYRDWERSQGSGQQHPRHPFSGPGRSRRASSGSFRQEDYIPEHRREPVGGANQTPFSDTARRGSASSAASKTQDPLHASPRERGMIEQSGHKRKLSPSWPRDREATKLRGDTDDRRSSYDRPDPSPIAASPHDPPLHSPSTTTPKTPMISSSNPRPADPRLAVGNTQKKPNSFASVFQEAAYAFMKREDAREAHGKAEADRNKVADYFNAFPVMRDRYEGRLEEARRELMLADMALKIKSKPLETICLEFARENYAKKELEPMVPFLRQLKHELGSSNSLAQFIKSSLSPSANLSQSQQPAVKPDELQRFSKELADLRKQQDDEAKLRRDLSENFRTFKDNSNKRFKTCEDKLKDVETSQRGLRSELDQTKEEMRRVVNDIREVQQSLAQSQESNTGNPQNAAPTAAGASPGPDAAEIKKIAEDSVLPLLGRYEGLQEKCQQLEPRVKELELKIDSIGVGSVSSDDIARLEKQLKIQDETIDSIRQSANSDTEVMMEQFTAIETGLQENHDQTSRLSADLEECRTTIVRNGMGQDKNASDVQAIQAILGEYRTDINALKVEFQNLIVRHHDYASKLHELDKNSSAITPKLSKEIEAIHTKLAKWENSLDGCLTAVTHLDQKMSAFTTKDFYERVVSSLVAINPLLFNTTNQLQHMLNENKKASTAVQRLLVEHQQHQASEPAQQQQHQPSQRVLDPSSTNAEAANGTANTREAAPSEGPGSLSQALKDIESHTQVLEALARRVDQHIETYNGKMSDIREWTISATKRLQENSDTCSNVEREIKLIQTFLNSANENAPAADSDQNQSQWRAVSASTAPRNPDLESDVQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLA2</accession>
    <name>A0A2T6ZLA2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1129975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLA2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLA2"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015493767" description="6-methylsalicylate decarboxylase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="27"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="349" mass="38821" checksum="55E3D31E4748FFF7" modified="2018-07-18" version="1">MYLHRYAQLFSSLLPLGGAAIPPSYTIDIHSHIIPDFYREAMINSGYELRNESVLWADGTPIPEWTIQEHLSSMDANGIDYSVLSISAPGVAFLHGNPIAVDLSRRVNEYMHNLTLLHPKRLGAFCLLPLPNVEASLVEIDYCIDKLNFAGVGLFTNHDGHYLGDAHLDPILERLHERNIPVFVHPTVPKCWHTVSHGIVPPMLEFPFDTTRAIVNLFFSGARKRFSNFTMVFCHGGGVLPYLADRVATLSAIPRFGGFDRKEAETQFRSYHFDLASATSVSQLAALKEFVGVDKLLVGTDFPFVPGPRGKAFIQGFQEDGVFTDQEVRRIKHGNVLGILPRVKAKIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLL4</accession>
    <name>A0A2T6ZLL4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_990687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLL4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLL4"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015495867" evidence="4">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="5">
        <location>
            <begin position="51"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="24309" checksum="9423FC757B062872" modified="2018-07-18" version="1">MRFFTVVLTAVTAFTALVSAQSATETSPPTPTLTDSKDNQINYPVGGTIGSGSLITIKWTPSTQGPITLVLRKGDGNNLGTITTIASGIPNSGSYDWTPSSSLPAGDDYAIQIISGDVSNYSPKFGIGLVSSSSSSSSSTMSTSTSTRSSSSSSSSSSSSFTNTTTTSSSSSTSPSASSTSSRANTTVSSTSRTSRTSSLSTPTSTSSGTSGSGGATSTNGAAHVASPLMLIFFIVAGIAYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLL6</accession>
    <name>A0A2T6ZLL6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_258697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLL6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="12471" checksum="8B3BB8FB63A38785" modified="2018-07-18" version="1">MLGSIQSFRPHLAYLVSHVSVYLSLFYLSSGFLYTASATPDGQSFKISFGTAQHTRQRRKGVHGTVLAALSTGIAALEALDNLSEVGGEEGREPPSCLRQMQSLVDKRKEKHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMA0</accession>
    <name>A0A2T6ZMA0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell division protein kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1087857</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Forms a stable but non-covalent complex with a regulatory subunit (SUC1) and with a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMA0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMA0"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="4"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU76617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="309" mass="35022" checksum="DE001E8AA1828056" modified="2018-07-18" version="1">MENYQKIEKIGEGTYGVVYKAKDLKNNNRIVALKKIRLEAEDEGVPSTAIREISLLKEMSDPNIVKLLNIVHADGHKLYLVFEFLDLDLKKYMEAIPSGMGLGTDMIKRFMSQLVEGVRYCHAHRILHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRTYTHEVVTLWYRSPEILLGGKQYSTGVDMWSVGCIFAEMCTRKALFPGDSEIDEIFKIFQVLGTPDEETWPGVTSFPDFKSSFPQWAKVDTKKMVPGLEDAGIDLLEAMLVYDPAGRISAKQACHHDYFIAEDGTDWNNGRPNSRFQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNG5</accession>
    <name>A0A2T6ZNG5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1087095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000166">
        <property type="protein sequence ID" value="PUU77032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNG5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNG5"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="16164" checksum="86C6AD1B1CCD4189" modified="2018-07-18" version="1">MQLRRPNTLVRLLLSFGADPNCFHLGETKAPLNLSVDRRDLTITRMLLENGASIDVVDLDNGDTPIHRAIKNSDGRMFRLLLEFNPNIEIQDRSGKDALAVARYRGEGEMVVELQTRLGLGVVELSLSEVDEVVEEIYDSLSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNM6</accession>
    <name>A0A2T6ZNM6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_988179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNM6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNM6"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="399" mass="44742" checksum="F7B4152454706EB9" modified="2018-07-18" version="1">MSNPSSDMRPSPKRIIVCCDGTWQNSDGGDKGVPTNVTRISRALKSYTDKGISQTVYYQSGVGTGGPVDKIVGGGVGYGLSEHVREAYGFLAHNYLPGDTIHLIGFSRGAYTARSICGLISRIGILTKKGMDDFHEVYDEYKDKKYSENSWLTKLQNKKGGPYVIPNVKIETISCWDTVGSLGIPTLHLPRVKDHNHKRYDFHDTGLSPQVENAFHALALDEERIFFEPTLWKKTEESKGANLKQCWFPGVHSDIGGGWADKEISDMTLAWMMQQLSGFLEFDESYLEKIIESGDLSSKDEWATGKINSETGIKRALNWKTRAPGMQDDTEETIHKSVRVRMMKFKPEWSSKALKGWTWNKGGYWTNGLKQIKEDQLGPLEKKLAGKAVVRDMLGEDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNQ3</accession>
    <name>A0A2T6ZNQ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1147228</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNQ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNQ3"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015731502" evidence="2">
        <location>
            <begin position="24"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="112"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="4">
        <location>
            <begin position="395"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="926" mass="100406" checksum="F70D86C42B3E4C8B" modified="2018-07-18" version="1">MFVFLPLLLAVNVISRLVDPAGAAAIRQKDVHRHNAAIVKRNLEARAKEEVLLRPIDIDYLHHSLNRRSDVPKLDDYSRLDPSVRELLMYGAPFAHEGGLFVANMTVNAPHGKKLLLMEKFNGFTREVDCTTAGDGRLSVILKDRRIYDYVYQIWGWLNKNDKNEFIMITNHKGCGLENERAVYRVYQVDFDGEELRVNFYSEEKEWSESIGSYSVDFGNLQVDGGESRDSLQARDLFARNPLDIGKAFTDFGKNTKKSFDEAGKDIKNVADKTGNTVVDAKDKVVDAFKDFGTWIKSLPKDVADQLNKLDDKLKAKFLEGAKKLKALGKDFVTVFKKARDKLGDKFEAVAKQISEIGDGNLGKDNVDFNLASGKSGVKKNLYTDPLNKNNPNDIIDCVDCYVTGKIVISGHVQFEDFLPKSAFFEARPVDLTTMMKFRIFARKSQDLNQDGKVDTGLKVEVDIFTATLPLVMIPGIFMLGPKFEFEVGVNSLVKSDVDFTFGFKGQAPNSAIYRKDLLDKNKHESSKWEGAKMEGLPFELLSGSLEAEFQASTNLVLAIGIQLAGIFGYEAGFKLKLPRLKRTYTTITKEDNTQACPGSKHETLANSTTGILEKNEINLDLIALVGEDRAINAKALQTTLFNIKIPFQDQCHPIVDKRTAEDKALAKWNNQQQGIPPATFGTQTPPTPQAIGALVPTGGAVPTIGAIDKNSTASPTIAPNPAVPAMPSTDNGQAPVIPAAPVAPPQVGPNTGLPPPSTLPGTSQPEAAPPPTLPGTVTPQNPTGPASVSKTLPGQTVPGQAQNLPPPASYPTAGQPLTFTPPANPAVNPGAQQYPAVAADTYGQQQYPPFNYPPASAGADPYAQQYPPLAPLSPQAQGIAQQQTPPVVQGYALQPQAPSYPPPAAPATPAATAALLGGYPGPFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNV8</accession>
    <name>A0A2T6ZNV8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNV8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNV8"/>
    <dbReference type="OrthoDB" id="2322999at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="220" mass="24915" checksum="112764FCB55E4483" modified="2018-07-18" version="1">MVAAAYIPHPYQPEVFAQLHNIDEAYRRLEEKTVSKEMLGEVRSLFIRYGVHRTLGIMVLHKHFDMTPEEKLVEFGNVSTPWLVPEANGDSVFGGKVVPRSWAFSSGHLYPIEFGFNPPTVENFPKMSFDQDFVVGLYGLLVGLGIGDLVGLTMLREDIHDMPYGIEKTVGRVSITLPITPETEPTQAVESVWTFGCHERMDNSKLWPARICWVCQDCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP85</accession>
    <name>A0A2T6ZP85_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_987395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP85"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP85"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8879" checksum="8C1A85DC3CB6CA2D" modified="2018-07-18" version="1" fragment="single">RSKAWEFYPYPCIGNFYFVEFTFANQPCYPDALRRVKQGGSLLDVGCCFGQDLRKLVADGCPAANLYGIDLCPEFIELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPN8</accession>
    <name>A0A2T6ZPN8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPN8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPN8"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="13346" checksum="30B4A6CA8D1BE137" modified="2018-07-18" version="1" fragment="single">LKPPSPKLCLLPNLRKRLVASIPTVCLAQTDYHLCHALPDMARDVEEMVDNFRTAEEAGMRKALSAGFGPSRKFVGASSGGIGGAGTGTVAEEGEEDEGSTIAGAEEESVADEGTEKEKENRGGGGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQB6</accession>
    <name>A0A2T6ZQB6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1108740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000145">
        <property type="protein sequence ID" value="PUU77680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQB6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQB6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="570" mass="64929" checksum="E0C36219DE50B008" modified="2018-07-18" version="1">MLAPLFVTTALLYIGYTCYSLHTLLCKVRPLGIPYFVVPFYPSPFIRVFIFPFMKLLIKVLGLTHPRFFLMTLDWQVRQRYEIYRFIGSDIFFTVTPWQIILHVADPDMAVEVLAGKDENGELYPKSERVSQVMGLFGENVLTVEGAAWRGHRKIAGPVIGKSSLSIVWEESLTQIQQMIQYYDKHEATNTSYRDFRRAALGVIAHAGFSKVMEWVPLTTPIANEKDREGSYQKHLHVLFENFMWAAIAPSWILEMLPFKALREAGGAANGFRFFMNEWFEEKKAKIELDNKTALNPSREDLMESLVRSSGLDKGSTLETPLLSKSEVIGNAFIFILAGHETTAHTIANAIYFLAMYPEYQVKLQEEIDSILGDSDHSLTSYEAHFDAFSSGWIAAIMFETLRLIPAAVITTRHMGPTTRTFPRTGSQRPVTLPPGIEFWIQIIGLSHNPKYWTQPGKTEAESAISEFRPERWLPKSGDNVMFKPYNGSYVPFSIGTRGCIGKKFAHVEFTAIMLGLFREMSVGFDSRGGRKTFEEARLECLAEMEKFESKITLQPTGEMPGIKWVRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQD7</accession>
    <name>A0A2T6ZQD7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_143372</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQD7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQD7"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="86" mass="9288" checksum="B6D4D6C4CF0FB896" modified="2018-07-18" version="1">MTLEELFVWAIGGGIWHGARAFRNGNSALSVLQTIKSRAPISGGSFGVWGGVYSAFECGLKVARKTEDPLNAVLSGFLTVRRREDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRC0</accession>
    <name>A0A2T6ZRC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1101591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000131">
        <property type="protein sequence ID" value="PUU78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRC0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="260" mass="29273" checksum="D4CABD3549EA603E" modified="2018-07-18" version="1">MTHHMYLIMLDGTLVVAPVENPQNILDVGTGTGIWAIDVADLFPSAVVVGTDLSPIQPSWVPPNCKFQVDDAENDWSFPRDHFDLVHSRHLMTSIRDWPRYIGQIYESLKPGGWIQMLEHDFILVSDDNSLPPGSQLRLWFDLYNQAADKIGLPSIAHKLSGMLSDAGFTEVTQTPHRLPWGPWAKDKKLKEIGAWMLANTETSLEAYGLAFMTRVLGKTHEEAQAICETAHKELRSKRVHAHNLHYVIIGRKPLEPLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS35</accession>
    <name>A0A2T6ZS35_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS35"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS35"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="21312" checksum="2FD28CDC5B4C79F5" modified="2018-07-18" version="1">MVLNFGSNKSALTGATNSNGDTAQSSGDLISESVPGSAPQSDPPTEIPTTVKGDSRNSITQPTTNQSALGVSAEKENSSEPSLSESANLGLSTMPRSTVPVADAEAPEQLDPSRGSSPSSGKTVTQDSNPETHNHSGYLAHLHYRSGPPRFTRPAVTTYSGKQPQGIISYSQADFSESKIYSAALIATPTPRIKYEPDYLTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSD8</accession>
    <name>A0A2T6ZSD8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1126837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000120">
        <property type="protein sequence ID" value="PUU78401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSD8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSD8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="17033" checksum="A8FE4A3186AE4280" modified="2018-07-18" version="1">MLLEKVEDLSFKDEAMRATIIHDAVDTGVVEILRMVLYAGASIHIMNLETGRFPIHHAFERGSFEMTSLLARKAAGCNMKEAMSVNTLLHIVFVSGYVHPEQDSTRDRDVDKRKCNASSGATGRKPLLGGAFGGSFGGGGASSAPLEHSMKPRECPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSH7</accession>
    <name>A0A2T6ZSH7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1101317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the free Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSH7"/>
    <dbReference type="OrthoDB" id="15735at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033745">
        <property type="term" value="F:L-methionine-(R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000008">
        <property type="entry name" value="GAF domain-containing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF15">
        <property type="entry name" value="FREE METHIONINE-R-SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="65"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="18997" checksum="C59C753048CBC68A" modified="2018-07-18" version="1">MVHADASNFTEGSTKAEIWEQAIESTEALLADQRNWAESNLANTASLIWHALKSMPEPSNHTNWAGFYVLDPRASKQLILGPFMGKVACQTIEFGRGVCGKAADSGEMQLVQNVHSFPGHIACDGETKSEIVVPIKVGEKVVAVIDIDSTVPSAFDEEDKKALEALAKTLGPACDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSK4</accession>
    <name>A0A2T6ZSK4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">B9Z19DRAFT_983146</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSK4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSK4"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023462078" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023462079" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="960"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="200"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1005"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="873"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="959"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU78458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114895" checksum="D51338F0F2EFF2CB" modified="2018-07-18" version="1">MNDSTLVLKATAVQGRNLAPKDKNGFSDPYLVLSLGDYRFQTEAIQKTLDPTWNDTFEMPLGGVCTSTMECVCWDKDIIGKDYMGEFGVSLEDIFLNGEVNPEPRWFPLKSSRKKAQISGEIQLQFSLSDSSNEAAPSEEIMAKWQAWQGNFVTTPNPSGDDQDPLSRDLGNELPSEDDDEVGDAESMVAGKKEKKGKKKDKRIKKGGHYELFSGTDVVGVIFLEINSITDLPPERNMTRTGFDMDPFVVVSLGKSTFRTRHIRHSLNPVFDEKMVFQVLRQEQNYSLNFAVVDRDKFSSNDFVAQTNFALKEIIETQPSADPETGLFNLREPLKDENSVSPISPGLKPGNGSKSRFRLPLPRSTSGTSLSAKGNGRAELSRKGSSTSLGGALDTLPAEETATPPSGNKIIPVNDITEYDLKQFKLPLPLKNKDRWEDKHNPELFIKAKYVPYPALRQQFWRVMLRQYDADDSGMISRVELTTMLDTLGSTLSAHTIDSYFERFRNQNGYDSLENTELTVDQAVICLEDQLSSATPKTPSHLTPHLRQLPVPGLKDRDNERDDASQKSLDTSTGSDTPDLRSSSAVSLPKIQTQSVLGSAGEEGLLLGDNDLVDEKAEEHVIQLKECPLCHQPRLNKRSEVDIVTHLATCASQDWRQVDKLVMGGFVTSSQAQRKWYSKVISKISYGGYKLGANSANILVQDRITGQIQEERMSVYVRLGIRLLYKGLSSSSMENKKIKKLLYSLSVKQGKKFDNPASARDIKGFIAFHQLDLSEVLLPLDQFKTFNEFFYRALKPGARPCSAPDNPKVIVAPADCRSVVYNKIDDATKIWIKGREFTIARLLGNAYPEDVKRYEKGALGIFRLAPQDYHRFHHPVDGLMGEPKLIKGEYYTVNPMAIRSALDVYGENVRICVPVDSPEFGRVMIICVGAMMVGSTVITAEAGQQVKRTDELGYFQFGGSTIVLLFESGRMAFDDDLVDNSNTALETLIRVGMSIGHSPGTAMVSERKENVTNEDKMEARRRIEGSLAPPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSX3</accession>
    <name>A0A2T6ZSX3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YkoF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1126546</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000115">
        <property type="protein sequence ID" value="PUU78577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSX3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSX3"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="118" mass="12940" checksum="18422DDF7BC8A676" modified="2018-07-18" version="1">MANSSNQEPLTIETPIAVYADFCLIPIGTGDPSVSKHVADVQRLLKKSGLNYHMHSAGTTVEGSWEDVTRVIGQAHSMLHAQGISRVHTDIRIGSRTDKQQTMQDKVASVEEKLARDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT84</accession>
    <name>A0A2T6ZT84_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT84"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="7909" checksum="5CE8A0457865AC14" modified="2018-07-18" version="1">MRNMNGGGALVGFSLVIILVMAMAVVMAMVVVGWLGGVGVFAEIAGCFRFSCSLLLGCYCVEWSGGHSTWMTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTF1</accession>
    <name>A0A2T6ZTF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTF1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="13296" checksum="B2B52FAE04CFB520" modified="2018-07-18" version="1">MAIVGMDYNITIMARMERGRFIEVMPIKIQAVAAEVLDYTGITDPEVLADNIDLPVTPLLVDSLKSAHRKKQWQGGNLNHGGGQQHRGSPGIIDHSTVNKVMLDVTDISYGGQSRINLARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU37</accession>
    <name>A0A2T6ZU37_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1082846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU37"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU37"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001194">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="40962" checksum="DD6F5B26FE6E6ED8" modified="2018-07-18" version="1">MAAANPLHRQLESTKLNETITRYRPSKAFSNFAQGAEVTSLDFDDTGEFCIATGDDETLQLYDCKLGKHSKTLYSKKYGCHLARFTHLQSNVIYASTKENDTIRYLSLHDNSYIRYFKGHKRSVTSLEVSPVDDQFISCSNDDTVRVWDLRSHNCAGLLNITAPSLAAFDPSGIIFAVAAQSASAILLYDLRNYDKQPFTTFTLTDDSFLSQYSYPPRMPAWSKLEFSNDGKHMLVGTRGHAHYVVDSFAGDTAQFVYRAKRPNGPTSPKKLETSGDVCFTPDARYLVSGQGERGVIVWDSWMQADEKKTLKPFIELAENTKSMASVVSFNPKMNLFATAHKDVTFWLPEQHAPDAPSPSAAPTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUA5</accession>
    <name>A0A2T6ZUA5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">10 TM acyl transferase domain found in Cas1p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1101041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUA5"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="627"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="307"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="840" mass="94347" checksum="CFC7EA7E24BECEEC" modified="2018-07-18" version="1">MAHRNTSRPSSASVIFDRIAAVFIAITILGVIIRYCWYDARDPFKCGALLNDGEWLDSTFNGTIPSNWQPPGCTIRKYDSKNIQSCLANRRALFIGDMTVREIFWATARSLDPEVRPQAVGEHTNLSVVKDDVTLEFIWDPYLNSSALATELAEFGGGAAGVGSGSAALVLMGSGLWYARHENLNWLKKWKDNIDEVVQHMREGRTSTDLAGSDILLLSPVLVPQYEWLTDDRRETITPDKIGAMNAYLEQLSSFQGVNVFWAFDEMIADLPQAYQSSGVRIKEEAAAKQAEALLNLRCNGEITHFPYDGTCCNKYHPPNYIQWLALVFVLAVLPAIIYMRHGGLEAAPASLVCQLNRLPSNEIVHSLLIFGLVVIYCFYADRTQVFSKSQKQFYSSDMLWLSLGALFFGLVAIRRTAPATTPDQPFLSREQSYEWKGLLLVTMLICNYTGGIQIAKINAVYRLSITAYLFLNGYGYSLYFLKSQDYTFKRCIAVLIRLNILSAFLPYMMGTSYVFYYLAPLATYWFLVIYLTLWIGEKHNSNVKFLLGKIFVSAIVTRLLPGILEIIFLIFGIAAGSRWDVSIWRDYIVSDLWMVYIGMVGSVLFLKANKNSYTSTRSFLLARRYAAAISALAIPLFYLFLASLGEDDEYSAYHSYVSFIPILSYLVLRNATPQLRDAHSYVFSWLGKCSLEAFALQNHIWMAADSKGLLELGAFGSSQKVTNFALATLLFIYLSYCVRRAAEVLTPWIMGIQPMLRKPSLPITSDGRKAKASESLDCDQDYFDVQTSQLQITRIEDGGPGLSPSTGDAQKSRWGELWADLRVRVVVIGSVMWFASIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUV2</accession>
    <name>A0A2T6ZUV2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1023980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUV2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUV2"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF53">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="490" mass="54736" checksum="BBE7E4C587E88E5F" modified="2018-07-18" version="1">MEGQRATKDTLDEKYETVSDGELWSTEEEARVRRQLDWRLIPLLTVLYLLCFTDRWVTGWLNARIQGMQQDLKLVGFRFNWALTAFYLTYFLVEIPSNILLKRIGPKIYIPALVIAFGIVSIGTAFVKNFQGLCVARAFLGIAEGGTMPGMAFFMSCFYKRGELLLRVAILASAASLAGAFGGLLATALSRIPKWGANGLEMHTWRNIFLFEGILTVGFGILGYFLMPESPGKCVFLSERQRWIAAERIRVEHKELTAERTELWHVKRGMFNINNIICCMGFLFCNVTVQSFSLFLPTILSALGWRATKAQLLTVPPYAVACCFTLYIARLSDRYRRRGLFVLVCAALTLTGYSILVSVNEPYIKYTAVFLAASGSFPLGPLFLSWGLNNAAGPSVRAVTGAYIVSLGQGGAILATWTYVPSDAPRYIRGHSINLGAQVGAALMGLLGILYARWENTLRDRGGRDNRLVGLTEEQVQKLGYRHPDFRYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV85</accession>
    <name>A0A2T6ZV85_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1064279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV85"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV85"/>
    <dbReference type="OrthoDB" id="10264449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="13410" checksum="2BB9316EEC8D05F7" modified="2018-07-18" version="1">MRLPKTPYPTPPEIRHAFALLSQRSTFKTFFDEHVSETVDWTAMGIDYPLAGHWHSREEFLRSAYEKLHSILDEDGLVLDVVDVHGGGIDEWAVVELKGRGRCRNGEYPYHDRLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW82</accession>
    <name>A0A2T6ZW82_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose-binding domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1100645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW82"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW82"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="25"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="231" mass="25280" checksum="BB867A02E0D01F0C" modified="2018-07-18" version="1">MADHSHSHCHDEHSHDHGGGAHDHSDDVTPAIQSSLYKHIDFDKITTLNEATPGSGRNVVRKSWEDRLASTPIVESDADEELLMFIPFTGLVKLHSILIGADPGVSAPKTLKLFSNRDDMDFSSASDTQAVQTLDLPVPPPGNDRVMEIPVKRALFNNTRSLTLFFENNHSDGEDITQITYLGFKGDWTELKKEHVVTLYEAAANPADHKNLVPGAKYGSLGLGGRQGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWJ4</accession>
    <name>A0A2T6ZWJ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000080">
        <property type="protein sequence ID" value="PUU79843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWJ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWJ4"/>
    <dbReference type="OrthoDB" id="10581986at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="143" mass="15870" checksum="97BECC37F2960447" modified="2018-07-18" version="1">MADSGANPAAPLEPLQASEIGRGPISQPSLQSLPSQESADHVDGWEIIGEQQDFYDERDCLHPSYSLASGKLKNRKVDDVVIFGYSLDPDYLKNEDGNPPTESATSSRPFSADDDIFFRMPKNELKEPEQFDRLLQGLRLGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWQ9</accession>
    <name>A0A2T6ZWQ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1063903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWQ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWQ9"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="283" mass="31197" checksum="76D5712E595FDE61" modified="2018-07-18" version="1">MPYSSPSLQPQRRPVQHSNNTSPPATQHTQMIQPPQFNAFPTSPFPNFTHLPAPCRQLHPPKSPLYRPAVLRSIERPARRENSPLTPPTSSAASVNEDYVGDGEYKNGMDIRNAGYGGYLGREEYGIAGLEEEGKVTGPPGKEHWKPDAEAVTCDAAMCVKNFSFVLRRHHCRRCGNVFCAQHTAHTVPLNQNARFHIQGYQERACDNCWNDYTRLLETKRPDYLSSSNSSSSTLSNNHPSPSSPVMNMGVRGPGGGKGMDGLGAKVGSYVGSVPRDWSWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX39</accession>
    <name>A0A2T6ZX39_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetrapyrrole biosynthesis, uroporphyrinogen III synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_976166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX39"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="295" mass="32226" checksum="12C7DE8385BA3C55" modified="2018-07-18" version="1">MSDSETKDIPILFLKTRSLPHEQYNEFFASNPLDNAVFTPLFIPVLKHHHVNLDNLKTHLITKFDSADPDSYGGLVITSQRTAEALSSIIPALPPTTLQNLFANTKVWVVGPATGSALVRLGFAASNVLGQNSGNGEALAELILESYGSRPKPLLFLAGETRRDIIPKTLSIAPEGRNITVETLTVYETIVDEGFETEFGKVIEEMKDTTRWIVLFSPTGADIAIDVLAKDLTSPSSGSYLAAIGPTTEKHLVDKLSRKPDVVAEKPTPQSLWEGIRVFTQRDRVKGDDVTIGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXQ8</accession>
    <name>A0A2T6ZXQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXQ8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015518665" evidence="1">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="91" mass="10498" checksum="A817B72B7F2A3597" modified="2018-07-18" version="1">MPIGRLTVATLIVSVVALLQTHRQEAEATRLARSDFDWCMRAPPAADIRDCHERELAELQALRAASKAPCKKRRGWYLRRRKGEERRGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXV5</accession>
    <name>A0A2T6ZXV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase inhibitor I78 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXV5"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10889" checksum="BC04CED874A64661" modified="2018-07-18" version="1">MSSNEERTFNRLLDEQRAQNNPASVNTASEAEWRTKLSGKKIIDGQAYSADTFSKRDLPEKHRVIPPGVVVTKDYHHDRLNVHVDEQGNTTHVTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXY7</accession>
    <name>A0A2T6ZXY7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1113953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXY7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXY7"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000003">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="29092" checksum="09C05BCABEBD75D3" modified="2018-07-18" version="1">MGGIMIQHLEDFNSETDSDYASYWRDWFISTRGHEYFCEIDEEYLTDRFNLTGLQAEVQYYQYALDLVTDQFDFECEDDMREQIEKSARHLYGLVHARYIITTRGLAKMLEKYKKCDFGRCPRVLCRSHPLLPLGLSDLPHQKPVKLYCAKCEDVYSPKSSRHAAIDGAYFGASFPHILFQVYPGLIPPKSNERYTPRCFGFKTHAQAALSRWQEGEREAQDVRLEKAGVEVRRVDGEDEDDEDEEVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY58</accession>
    <name>A0A2T6ZY58_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_735149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY58"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="80" mass="8920" checksum="A882237F121C144F" modified="2018-07-18" version="1">MTPRITIRSAPPKPCILKINPDLSKTCAFYKANFLKTPTGYRTNPSPTSECTHFPDRVAEWISLLARNGSTLARSAPWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYB9</accession>
    <name>A0A2T6ZYB9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1079418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYB9"/>
    <dbReference type="OrthoDB" id="5286008at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045290">
        <property type="term" value="F:D-arabinose 1-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070485">
        <property type="term" value="P:dehydro-D-arabinono-1,4-lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19164">
        <property type="entry name" value="AKR_ARA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044480">
        <property type="entry name" value="Ara2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686:SF1">
        <property type="entry name" value="GH17980P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="350" mass="39255" checksum="688E1711FE33C790" modified="2018-07-18" version="1">MSAEKPKLSSLIPPIIIGGAVYNTQMNPDPSTLPVRNLLVKAFSMGINCVDTSPYYGPSELLIGDALIQPAITRSYPRSSYIIMTKAGRIAEGEFDYSPSWIRKSVRRSCERLHTDYIDVVFCHDVEFVSADQVIGAVRTLFELADEGRVRYVGISGYPHKLLAELSVRIRKELGRPLDVVQSYCHMNLQNSTLLQSMDKLRNEGGVDTVVNSSPLGMKLLTGTFPGSFHPAPEGLRDACARAAEFCEAQGETLPRVAMRWVFANWKGATLSGVSYLEELEGNIGAYMDVTVSSEEDKEGKVTWKDVDERKVKRWEALWKGVQEIFGEWKDYSWDSPPRSWTFGKRQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYL5</accession>
    <name>A0A2T6ZYL5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1079002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYL5"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="40018" checksum="FE10BFBFDC2ACDD6" modified="2018-07-18" version="1">MFYHSIPNPLSPLYRGGFMQTVEWTLSECPPLRSKIAIITGGQSGIGAEIVKQLLLHDIGHVVVLARSREKFEFAREEWGEIKGYGEVAERVEFVECDLTDLKVVDKVGKDLLGRLGRLDMLFLNAAIPNIPNYELSPQGVETIFAANHLGHFHLADTLLPLLLSTPKTHSVSSTRIIVSSSSLHHLCRSIDVQSLTSPNPPSSNLGAAYTSLYRYARSKLANILFTKALSRRLENEKVFVNAYFPGNIPTSSMDTWKEHFGYAFGSAFSEFFRWMGQTLEDGATTGLFLAAAKEVETDGNRGEYWAPIARKESCSMTAEDERLAERLWVWSEGFVKGALQSGHEAGVDASNDVDADVDADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYY1</accession>
    <name>A0A2T6ZYY1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_973960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYY1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYY1"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="66137" checksum="D165BF975F8ECA03" modified="2018-07-18" version="1">MNSPKSDTSLRNIAEKIKDVSISGEANRIVVGVDFGTTYSGVAWGYTGSPSEIHVIQSWPGGMNLTSPKVPSKIAYEKDGIKWGFQVKPFQNCIECFKLCLDPNLRPPDFVSLPNIYAQLRQHDKVVQDVVRDYLQMLYDHTITTLTRALGSTFVDNTRIEFILTCPAVWSDRSKNATLQAAEGTGMAKSCKIRLISEPEAAAIYTLKTMQPKNLQVTDDSCFVVCDAGGGTVDLISYEILQTDPLQVKESVTGTGELCGSAFLNRRFESFVKERLGSAAYYAMKEKTKIAALKSWEEYVKRVFVDGEDQDVFPIQFPGLPDDEARGIDCGFMTVTREEVQAIFEPVIQEVVRLVDGQITAVQSKGRQVKSILLVGGFGSSEYLFMRLKNKYADVLSTKDNPDVVLQPVDSWTAVVRGAVIRGMETIVQTRKSRYHYGVKYWEYFDENIHSEEHKYWDTTREKWLAENQIKWYIAKGTEMSEDESISFPFYITFEDHHSRVLVDELVCCQETFPPKSIDSTVTTVCKLRSDLTTVPKSLYTKGRNSKDVEYEGLHFTMEMSVLSAALLFELRVDGVRYGEVTADFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A082</accession>
    <name>A0A2T7A082_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1122557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A082"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="8506" checksum="520EBC2F5DBFB890" modified="2018-07-18" version="1">MSGSGTRWLAPELAGWLTFPPADAPDGNEIIWIAYRLLGLPGVWACPQTPPPLLSHAEPRWATLSHDVGAFSERLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0B1</accession>
    <name>A0A2T7A0B1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1191356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0B1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0B1"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015742035" evidence="2">
        <location>
            <begin position="19"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="118"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="37858" checksum="B3D8FEA3BD272C3F" modified="2018-07-18" version="1">MKLTILSLLLFLLPLAIAAFSPAPPCPAPNVTIPVLDPVALAWLNASSGSKPIYEFPIPKARVLYDVLATGNVSSPSPTDISTEILYLPVGPTGNVTVYLYKPESSDREEGQGLLPVVVYFHGGGWIFGGPKSYEGLVYDLVHETGAAVFFVDYTRSPEAVYPVPIEESYSAVQWLLEHGEELGVDSTKMGFAGDSAGQMSAAVTLLSTKRNTPLPKYQVLLYPVTDLSCESPTYKELAQGVGLTPDVIRWMISIAAPDVNSRLEDIASPARASDEDLAKFPETLIIVAEVDVLRQDGEDFGRRLQKLGVRAATFRALGTIHGFASVNPLSQTPVARAAIELVGLKLKKALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0R1</accession>
    <name>A0A2T7A0R1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1122217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0R1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0R1"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="478"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="656" mass="72070" checksum="F3B91576ADF21239" modified="2018-07-18" version="1">MSSVVNKSKNKFVPKAKARPRPRAAIHSSPSNPTPPSPSKPPQPAEQPPTPLAPPVSEPAVPPSQPEAGGETPVAELEPPRRQVLVPAIRTKTGNGTPSIRQTSTEVFSSPSRSGIPIVQSSSSRGIPRIRAAAPEVAPTTQLSSAERSPEALRAANTRPNAWLATVLGGTVDMPVFRDSGVATTQETQEVSQEDGAAAGMEGSTENIDGGESPTIEKVAKPPRKRKARAAKNGLPKRQKATRGRRKAAEDNIYGAQEVREAQEGQEGQGDEQEVAGGTEVNVEGDNSDNSLYKDPQKSDKPGKTRRPRKPAAKKPPKEPSEPNRKRSSGRHRAPSPEDGEQREITPSVIKMKDLCRDIRIGRKSKRFIELEQMDWTKLANDQKAAKAALEVRQAAGEEVERETVEENIEGLGNESQGLPRAGAPQMRMVNGELVLDQESIQVNSHERNPIDEESMEIVEENMAFRRITSATYSKHKRSERWDTEETDKFYNALSMFGTDFEIISKLFPGRNRQQLRKKYLNEERKDPQRITDALRTRVPVNVAEYSEMTELEIGDPQLVEDELEKIREAHEAEEEAAIGHAAAMERERQENANAAMRAGDDAVAAAAADQNKKGRKKKGAKDRGGASHGGEEILSMSREEYEAEWLRELAEAEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Z7</accession>
    <name>A0A2T7A0Z7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Z7"/>
    <dbReference type="OrthoDB" id="3267074at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="21207" checksum="AF762CD5202C49C9" modified="2018-07-18" version="1">MSKTGDAVECAWITIERGMADTPRCQRLPGQWGIMEVELMGILGSLREWTGTGRSIRIHSDCLPAILMLRDMTPEGDTAMLFHLMAEVLNNINGDVGFGWLPSHVGIPGNEMADMGARSGSRIAVLPEYVESIDFGLAQVRTANRLRAEEWRDYHISFDRTYYDRGLAKPRFMKGLSRMDYYYLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Z7</accession>
    <name>A0A2T7A1Z7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000040">
        <property type="protein sequence ID" value="PUU81760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Z7"/>
    <dbReference type="OrthoDB" id="5395290at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="190" mass="21268" checksum="60713A4AF95B8831" modified="2018-07-18" version="1">MSMQTIDHMIYMLSELGLYYFYHQPPTSRAISKHNQQLLRMLSLLSLIIVTEGSGDVAAVSLHATAGKGIELYYSKNHPCTPDETAYVIELFATATNSTSSTKQDDVSFATSNLRARVDGNPMATQCDAKIRKLVGTERFTLECSLVDFLKSWFQLLLSSLQHDPFFDLPANESLLRDTITISYFLAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A283</accession>
    <name>A0A2T7A283_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A283"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="70" mass="7560" checksum="CED040C6DACF5438" modified="2018-07-18" version="1">MSHEKNSEAPIATLSSAGLINGEKAIKKKVAKGYYTTRILLEFESGDGGNGWILLLRAQGGEERLGLIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A293</accession>
    <name>A0A2T7A293_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1121628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A293"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="330" mass="36484" checksum="67DDB8ACF2E419E8" modified="2018-07-18" version="1">MADLNPLSNANPVEVYTNPITSSEVPNSSPTIPTPSGQPTVGESKAGLEPPAWHNIDELFLWDISFDKWKNSKSSVEVQEPPIVVNPLSETDNVEVYTTQIIGSEVPNSSPTTPTQSEQPLLSETMTWEEAMAWVESSLALPASDDDFFRFVPDQPEGDNNHKLSVEVQEPPMVVNPLSKTDPVEVYTTQIRGSEVPNSSPTTPAQSEQPAPSEIKTWMGVLTQETINEHSPSSDILSYPPMWDPHILSVKAREPLVAATDRAGIDAQVSQQPEGERHISCPEEHWFFIFIFSVIVLMATTTLLFKGKFWRKLRRCIICCLMALGGDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2F2</accession>
    <name>A0A2T7A2F2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1099531</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2F2"/>
    <dbReference type="STRING" id="42251.A0A2T7A2F2"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="505" mass="54754" checksum="7904B2099921DDCE" modified="2018-07-18" version="1">MQNTVGLYEYQYKILNYQNGRVYLISYWTRGIDNEYQRKLLVVVELNGFGLVYVQAWFLKSSPKVTLLIKLPTTITSATVNRFMSSPGTISAVPKFSLLGRIVITLLGSSPPSLACGIWTSRGMSLRPQSSQLPLNAASIELTPSPSDTTTATRARSEATFDSPRCIFLNHSSVHPSEIRGEHLVTPDRTQSSCKKFPPWTVSQGMTLAPNSILRKCGLIGANVKVVKFSFCAGGDEVFQERHKNALIESKWLLHNPLAVATPGQSGNGGASSVSIAGPKGAATNVPKKEAAIEGAFEDLEALMRCAKEMLALAEELSTHLSSTPTFYNSEAKAALPNSTQELGIMIMDMLTAAIGGSNSSSSDKPSDLYFFEHARHVAEYLTDNACGIHRQGIIRWEGGVIALVDLLAIYDKKAIALFEKLKLPVRVPKFWSGLLVVPEARSSDGEIVRRIMGWVAGPGWGRGVTEAQAAERFGWSIGVAAEELGMVEDRGAPCSEVGVEGVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2F6</accession>
    <name>A0A2T7A2F6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_888929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2F6"/>
    <dbReference type="OrthoDB" id="4768051at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="569" mass="63171" checksum="2923DB65C3E79AE4" modified="2018-07-18" version="1" fragment="single">FDSWKQFWRNMTSLSWRCLTTALSLSLLILGLRIFSRMGELSHKEQRGFNAITILLGSFASLGLGSVLGYLGSMLRWRLLARKKYKVQDIELLLAMSSPNGSAVLLFTHVGEWRLSLTTFIVMLYLLVNISGKFSVAIFGLTYNLVDDLVEVSPTLITDWSSSVLLARNATDFQVVEKTTLGGRRHTRDGIRVPQDLTAWLFTSLWVDYSYPTESGGNVVFVYHIPEFIEGKRSPTLGHTVHSSANCTMFRLEGHKYWKDYETGDETSEGWDDETNRQIAEVLRALESKNAWPQQGAEQAIWAAPLVGGSNVSSLTYILYHGTAWECTSRLFETLKGSHYPKPLFGSSTLFLLPIAERAERAPEPASRLSNSCGGPSGGRTPSIVYRSFSDLKSQSSPSVGVQNLNFYQNGTGGSTTQKNYYNLYIAGLVARLPIAAIAYGNEVFPRVEKVPDARWTEYVETKLEVKWGRVGIAAGTIVAVQILAITTILYYCRNVHVREDSYLTTAELLKTVLNRIEDGNTMTAKELEDASDEALEGPISYGTIPGPQKDQLRVALGCGVDDNFPGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A319</accession>
    <name>A0A2T7A319_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_492510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A319"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="16511" checksum="E8B2D7477D3183CD" modified="2018-07-18" version="1">MPSDIEGWPRSCFLSATISGCTAAVDCLEYFWIAIEHDRSAELPSLLQQFISHSLPGSLTREVLSGLSFVWFPEPSYLRTYTSLCVYLDRIFNARPAHLFLTVTCLSFAVIPLPAPRPLDFFLGVDTGRQTGPKQGRTRGWPAGTVQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A378</accession>
    <name>A0A2T7A378_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1075456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A378"/>
    <dbReference type="STRING" id="42251.A0A2T7A378"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="53"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="395" mass="42797" checksum="B0F2E3B8300CE114" modified="2018-07-18" version="1">MAGAYSQVENSHAHPKEIKGPSSVTRALLRMTEGVPLVHSILIEKDSRRIGYFMCLNFAFMIVQTCYGFMTGSLGLISDSVHMFFDCLALGVGLCAAVMSKRPPSMRYPYGLGKMDTLAGFANGIFLMLISVEIVWEAIERLQAPTEMARLGELMVVSSMGLAINLVGIMAFDHAHHGHGHSHSHSHGHGHSHSHSHGQSHAHENSCDHLHGHDSHHHHNHGGEPPASTHNDHAHAHNSENMHGIFLHILADTLGSVSVVISTGLIHYSGWTGFDPLASVFIAVLIFASAIPLVKSSASNLLLTVPDNSEYTLRETIAGVSGLKGVQGYTVPRFWEVEGAIRGVVHVQVARGTDSDEIRRRVEEWIETGLGKAAEVVVVVESGDGSSHCWCVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3M6</accession>
    <name>A0A2T7A3M6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1112900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3M6"/>
    <dbReference type="STRING" id="42251.A0A2T7A3M6"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="46"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="9">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="24366" checksum="415F481751A47089" modified="2018-07-18" version="1">MYGDLGLKLVQHAKRTQSLSQLPPYQSDIVRSVTREVRDLDRDVTEMLEPFNGHFDPAEEPATACSLLVRHLCMRRDKRCLLAYHRVRVEMIEGMCWSGSDLLDQVQASQNKVAEEGARIGSAEGSGASSLSPEEEEYARQYEDLLAAYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGAITLTKNSQFFVRQGDVERLIAQGFLQKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4C6</accession>
    <name>A0A2T7A4C6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_897212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4C6"/>
    <dbReference type="STRING" id="42251.A0A2T7A4C6"/>
    <dbReference type="OrthoDB" id="4363844at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF28">
        <property type="entry name" value="TRANSPOSON-ENCODED PROTEIN WITH RIBONUCLEASE H-LIKE AND RETROVIRUS ZINC FINGER-LIKE DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11206" checksum="50285474F96B6200" modified="2018-07-18" version="1" fragment="single">LPLTIWGEALTHAVYTRNRMPHATLNNQSPYEVLTGEMPDLGYLQLFGSPAHVFVPEERLKMKGKLLAGSVEGFLVDYGQQRNHYRFWIPSLHRVVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4D8</accession>
    <name>A0A2T7A4D8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1074722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4D8"/>
    <dbReference type="STRING" id="42251.A0A2T7A4D8"/>
    <dbReference type="OrthoDB" id="5427204at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="350" mass="38276" checksum="DBB4987CA2F159E9" modified="2018-07-18" version="1">MEAVRDREREEQGSAYASRNQNQFHLQSSTGFRPGTPARGQQHLQSQAPPAPSPSNTLSVLVSSIHNLVLDLTVSSQSPAYTIPAQITPHQIPTIETLTTCLETVFSLLLRLKSPTSQSPSLPPPPPPPPPPPPQAQHPQVTALSQSCPPNQNLPQTLSALQQTHNTLLKTHKSLQAVHARSQTRATTLEKKLLVCTDENENLTNERERLQGVVESLEESLAEVREERDEIRLELRKSGAQWGRILTNAGRLAEGASRVERDLRGEVGNLREEVGLLRGRGGDGDSLMSGMESGGFVGGSGSGGGDREVRELKLRVRELERNIEEARRDGRGVIEMAEKLAMLGRGIIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A500</accession>
    <name>A0A2T7A500_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A500"/>
    <dbReference type="OrthoDB" id="5333220at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015483216" evidence="1">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18582" checksum="A3719690C180ABA8" modified="2018-07-18" version="1">MKSAFISVISLLCLIVPAIAGPVGNPINWMEQPSDLIDLSQFPDHLFEATGRPVPAEVVKAYGLDITPGNTTGAAIFENDNPKAEWTTVGGIQCTQWNPGHPYCTELITFGGAHIGVCGEYLYWLWCESAAGFTQSLLDQCKNNLGGGERVGGYTLIRGWPGQPGFRGMMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Z5</accession>
    <name>A0A2T7A5Z5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1073170</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Z5"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Z5"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="74"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="163"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="377"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU83171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="480" mass="53610" checksum="EADF4B356C99BAFA" modified="2018-07-18" version="1">MSLAAATTSRRLLLLRSRVIASSFTTSTASTGPPLLQCSARTGTKKSRVGPGIRFESLRAFSVSMGRQEFQKIKVKNPMVELDGDEMTRVIWDWIKTKFIYPYLDIDLKYYDLGILYRDKTEDKVTVEAAEAILKYSVGVKCATITPDEARVKEFNLKKMWLSPNGTIRNILGGTVFREPIVIPRIPRLVAGWKEPIIIGRHAHGDQYKAQDFVAPGPGKLELVYTPENGEPERIKVFDYKAGGVALAMYNTDDSISGFAHASFKLALQKKLPLYMSTKNTILKKYDGRFKDIFQEIYESTYKAEFDAKGIWYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHYREYQKGKETSTNPIASIFAWTRGLIQRGTLDNTSDVVAFAESLESAVIDTVQLDGIMTKDLALASGNEDRDSWVTTSVFLDSVEKRFKASLEAKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6K1</accession>
    <name>A0A2T7A6K1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000014">
        <property type="protein sequence ID" value="PUU83371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6K1"/>
    <dbReference type="OrthoDB" id="5475159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="20757" checksum="A8F89A6C38039B79" modified="2018-07-18" version="1">MSQNSHEGISGLYLPTYTPSSSGNEIVSQTPTPPNLSKAFHDTTPDPGAPTLACPVSSCSLVFKGDIAHGYLWRHLKRPGIHGRTGDEKIIWLNLHKTEHDRLLATRITPAQRKHEARKAKARKMLRTVEFELRARNMGVTEKALIAQKVAIWEGMYAAEQSGDSIGVGILIPLHFRGRGGNVADCRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6M8</accession>
    <name>A0A2T7A6M8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1119379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6M8"/>
    <dbReference type="STRING" id="42251.A0A2T7A6M8"/>
    <dbReference type="OrthoDB" id="5413729at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14903" checksum="1CC86657BD10C51D" modified="2018-07-18" version="1">MSGKETTRDERVQIIALQDKASLTWKEIGRKLNIDFHTCQKIYKYVKINRTPSNKRRSGRPMLFGAEEKTELLAFVTHNKRTRRLQWEEIIAEVGYSYSVRTIRSVMALLKYHKRLPHKKLVQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6T2</accession>
    <name>A0A2T7A6T2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1072670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6T2"/>
    <dbReference type="OrthoDB" id="5379605at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="170" mass="20013" checksum="32F71D8101A176F9" modified="2018-07-18" version="1">MYHAGDRAIVPASYRNSRSLPESYSLVHQSKPRTGVRYGSGGTIYHNQQPGATMYHRQTMYQRQPVVYHQNGRTTRYYGNQNTMYHNNQVGRYNGQGTLYHRNSRVYQSPMDLDPYTGRNSYHEQRYVVPVNNQARYIRGYDPQARQSRRYGYRDTYHREVVEPSCCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Y6</accession>
    <name>A0A2T7A6Y6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Y6"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Y6"/>
    <dbReference type="OrthoDB" id="5362630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="71297" checksum="93EBC1C1BC0770DA" modified="2018-07-18" version="1">MLNSSKTCNNGMLFTPWFDPHSGPTPHDLPGDDEHGLGDLLSASGVPNLKSGQYPAFTNMFTPEQYLSTIDFNLTGDWLAVGQANYLDGLNFPCGYDDFANMDPSNLARLDDCVTNVENNIDICQELLRLGTNLPMFDQSAPWDQPGAWQPTPVAPSCSPASTLDASVGFHTPSSSSAGDHEESSDHQQNQRKNSSSESSDGEPRNNNSCKKKRQRKRFTPELKKETHMTRITGACLPCWKNKKRCIRVSEACCKYCESIFSKIPNIPCFRARMTESELFRRGPTEEFLWTRRRWLKASPNDRTVWASQAKGFTVTQGMGLTLNLMAKQYKPLPDDRDNYTWIGQNGEVAALACPPYAISDIDDAQRTINRYVEDNTVRYIQEHVSSNVILWESFSMALRMSSAKGSSLLRNALKLWVGSRIIETPWSIIGNETFGMTTNMEEGSPYYGKIPVTPIMDFQIDNITIHQLLIPLRKKLLQELQRKVLNNKPEDFLEIYLTIFILLHNMELTIAHDRWFAMRYSLQNRFSNYHLIDAVFQGANILLAHFHHVSKGYAPFSIDWESGETIVLAKSNEDEVRYMKEVIQATKHQESELKMLREKEIYEDSMYWCSQLFFPGWKPVNAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Z0</accession>
    <name>A0A2T7A6Z0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1141624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Z0"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Z0"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="141"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="431" mass="48597" checksum="041AE99C5BBB9285" modified="2018-07-18" version="1">MLVHGGYSSGNHTPSFVPAYKPFSETLNKRDATTKQIRGNFSISENLATFKSSDSASDPPIDWIPRYSSYINRSQRRLRQGGLTKTLPAGFPARVESPLAWTASELKKEEYTVVLSEEDILEVERGLRDFKESKLAISLITRQTFQLPTLGPRLISLGTSLYNGRGFFVLRGLNPKKYSSEENVLIYAGISCWVAEKRGRQDEHNNMLQSRTNKLQPYHTDIGDILALYTLGQAYTGGRSKLASTGAIYNELAETRPDHIDTLQSPEWIFDTFGRAGEPYYKRPLLFNQDGKMVFAFSRRILTGSKVSPRTKGIPDMTDAQADALDAVHFTADKHALTLDDGQLGDILFWNNMSIVHARQGFIDGGPMNQKRHLLRLWLRNEELAWKTPEVLQSAWNVAYGSDDVSEEKWPIEPILDRDHVTTQRRSSGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A762</accession>
    <name>A0A2T7A762_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A762"/>
    <dbReference type="STRING" id="42251.A0A2T7A762"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="21847" checksum="94AE8BA094440425" modified="2018-07-18" version="1">MSDVYIEREIVPVKVRRYRWPELLLAVILLMLLVCGAIVLGSFAYFTAIQQRLFMAVPWYYYFLLSISTLTVIFVFTVVALYYVHLLLPIIVMISSFIMFVLWLTGLIKASIELWGPLGSINDNCTRYVYNNSFWGGRNIDTLARIQQEGVCNLWKTTFALEMVATFLFLWLILMSWQVINRARRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A774</accession>
    <name>A0A2T7A774_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_820904</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A774"/>
    <dbReference type="STRING" id="42251.A0A2T7A774"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="275"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="497" mass="55982" checksum="A99E8767DB30E31E" modified="2018-07-18" version="1">MHRFFFSREQQLAPTTAEPSSSLPCASLPSTSYSVSSDSPPPLAGSYMHDYLLVEESKSDKHHRDKSGSPANSYTRQFSAQTVSTDLVLRAAIEAQHPHQKLTVCRDYSCDIFGYASSTGKITLTPSISKSDPILSKLTFQPSSRRANGPGSIEHSIDFAKFMLCKDGKEYVYYFATWPEGYTVVRAHYFLHSEKEKMDIEDIVLQVCAYTMELHQEILVLNNGVWSKDHALWKSVQKADWKDVILDEAMKHRLRSDVENFFNSRDVYKHLGVPWKRGIIFYGPPGNGKTISVKALMKSISYPSLYVKSFRTYMGDEYGVAAAFDKARAFAPCLLILEDLDSLINPMNRSFFLNELDGIAENDGILVLGTTNHLEMLDPGIVNRPSRFDRKYVFPMPNVEERKMYCNYWQAKLKGNDKIEFGDGLVERIAEWTSDFSFAYLKEAFVSTLLIIAAMGRGGGGGDGDRGDGDEDGDKPGLFERIIKEQIDSLRREMGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7H6</accession>
    <name>A0A2T7A7H6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_785304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7H6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19708" checksum="77888B44975D117E" modified="2018-07-18" version="1">MWKGGRNTAKFSVLTYQASLARGRSRFCASLNCLNSQILQLIALLDETYCCWRPRCIPLTHGLYYKRFMTFYQLKHYPVGHWCCIKGSQERSWSRDSSTLLKSFLLRLSIGIGTRKSLGRVTESASTVIFGFTHQTKLPPLTVKPPSLLGSRTTSAWFSCLAFSTSPSTIQNPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7H9</accession>
    <name>A0A2T7A7H9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1071903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7H9"/>
    <dbReference type="STRING" id="42251.A0A2T7A7H9"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015395455" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="349" mass="38023" checksum="C3B1C76765FE189B" modified="2018-07-18" version="1">MPSVGAWLVSCLYLASLLGNVVAGPLPEDVATRWGSCKTVIKRKEWRTLSKDEKKDYIKAVKCLQAKPARGKATIPNSVSRFDDFQGVHIQQTFSIHFVGHFLAWHRYFVATYEKALREECGYDGAQPYWDWTLDANNFLASPLWDPVTGFGGNGAYILPDTSPLAVPGATGGGCVTNGPFVDMRLHLGPGASLNATSRCLRRGFSPLIAQTFSNTARVNNALAQVDFGWFNKVIEGETNFVNVGIHGGGHYSIGGEAGDLYASPGEPVFYLHHANLDRIYWQWQSMDLPARLRDISGPVELLGPITGPNVTLSFPIDLGPLAPGVTIRDLMDVKGSKAGTGVLCYTYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A816</accession>
    <name>A0A2T7A816_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1112172</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A816"/>
    <dbReference type="STRING" id="42251.A0A2T7A816"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015550594" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="240"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU83874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="358" mass="37035" checksum="F1F62E3AF07281C4" modified="2018-07-18" version="1">MKPSFILSVLGAAGALAHGFVSQLLIDGALYDNFNPNLDPYQNPKLQKIGWTIPNNGPVESVTIAGIACGTGSAAGSLSAPATAGSSIKFFWTQWPDSHRGPTMTYLAKCPNTDCTTADPTTLNWFKINHAGLSDGKWASDALIADNNTWTVTIPSDIAPGPYLVRHELLALHSANNANGAQFYPMCANLKITGTGSAVPTDTVKFPGAYSPTDPGILVNIYYPVLTNYTIPGPAPYVSGGSSAPVPSSVAQSSVPTATSSGAGSRIPTLSSSATPPCSSDTSTHSKLPQTTQSAGSPPKEVTPVVKSPTTPTSAAAVPPVVSTVIQTVTVTQSCPGVQAPERTPTGRYRRSIYGYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A877</accession>
    <name>A0A2T7A877_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_962206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A877"/>
    <dbReference type="STRING" id="42251.A0A2T7A877"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="393"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU83915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="662" mass="72635" checksum="195ADC4B32405EF6" modified="2018-07-18" version="1">MPPDKGKSKVPTFFKPKLPSATPDPSSQLTSDPYEPLPQSTRPQAPRILAVEIPLNVLRPVAFRVFTKKHNLTLKSDALALLCSFVGQRCGAEWRDSGAGEKLLDEVARQWRRNEGANGVLVDGGEGLKSVIRGLEVGSDSIGASREKSFDITGVPSSALYDGGRSMDDIGGTAEAGELEDVEPCAYLKVIDAFSQPKFAYNPLKKQFEKAPKPSLLPPPQTKTQLFRTRYNLLHQRLLRTETFQLPTFSAASSSAAKAVNRLTPISNLLGRSGQSFLLFGMLGVSPSGLLILLDPSGEIVLDLSVATAIPEDGSWFTPGCFCILDGAFEETGKFTVFTVGQPSAERRTTSVEVFGHVDFLGNGVTLDMSVSSGGQQGRMLRKAEKSLEDVKFLFIGEVELDGKGTLEALRKVFSEYETEPPLVIVLMGNFCSVAMGSSGGSVGYKEFFDQLASLLQDFPTLTSSSTFIFVPGDNDPWASTFSGGASTTLPRKPIPEIFTTRIKRVFTQSRSPNSVVWASNPCRIGYFTQEIVICRDDIFSRFQRNAINFKKPDHPMEDALSQPEATRDEEEVDVKTRNTKAFFLHSPSPLDRFYGITGILLAFTHYLALQLILADPRMQPFVITYESCHVMNPGKLVQRRMARWVEYSPSIGKGKVCEAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8D0</accession>
    <name>A0A2T7A8D0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1071203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8D0"/>
    <dbReference type="STRING" id="42251.A0A2T7A8D0"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="35516" checksum="7FB897686314C0AD" modified="2018-07-18" version="1">MFGRDMCQTAFDLRVLHLPCKEFLWNADSSHEWVGYIDGQQEYPSFLETLRIFLDPKKQFPVLSPLSSMFILHGLISVGYDLHRRSSPIGPSPEETAAKQARLLRAYEKWATYYEMNVSQHLSQSCNNRNMVMYHAAYISLHTNIHNLTTVAGDTRTYKRSPERGDYYRAKAELQQWANSGSSQLATWHAAQILVRSLNRTHVYLELFHVPWCMYIAALVCWAYGQLSPSAVGPGGLPEASDDKAVWDAHQDMRVYLGQMSTDSWESLPRAGGHRRTAGLIAVVKNTLEGVRWGLTHGSVDVLRRLDGSGAGKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8H3</accession>
    <name>A0A2T7A8H3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1070844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8H3"/>
    <dbReference type="STRING" id="42251.A0A2T7A8H3"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU84029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="15403" checksum="99190FC87CBB8317" modified="2018-07-18" version="1">MPSKKNLSTPSTSTSTTTTTSSSASATAAATATPTNPFTILGGIFKNYSRSTPQRTKLIDAFLGFLVITGVLQFAYCVVAGNYPFNAFLAGFSATVGQFVLTASLRIQSNPANKSEFASVSPERAFADFVFCSIILHLFCTNFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8H9</accession>
    <name>A0A2T7A8H9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1070856</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8H9"/>
    <dbReference type="STRING" id="42251.A0A2T7A8H9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000095">
        <property type="entry name" value="ABC multidrug transporter Mdr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="174"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="493"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="768"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU84034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="796" mass="85307" checksum="02BF1175A8B5299B" modified="2018-07-18" version="1">MRSSPSLSSSLRSAACSRVTSFTSPPRLICHSAKTQTIATPTTRIFSGGSASLLGLRLREPLLQAQRSFFPGFPSSNCALQSSVRSQERWLSTSPILREVRSNTTKKSLAGPQKSTSIEPELEAFGRSEKATKAAQVNLSARLHKDGNPSAVKPGLGETVRLLKIARPEAKWLAVAFVFLLMSSAISMSIPFSIGKILDMATQTDGGTLLGLQLPQFYMVLGGVLCLGAACNYGRIILLRIVGERIVARLRSRLFHRTYLQNAEFFDANRVGDLISRLSSDTIIVGKSITQNVSDGLRALVTGAAGLGLMAYVSLKLTAVLAVMFPPVAIGAFFYGRTIRNLSRKVQKNLGTLAKIAEERLGNVRTSQAFTGEILEVSRYNHQVKKIFALGKKESLISATFFSSTGLIGNMTILAILYIGGQQVKSGAISIGELSSFLMYTAYAGSSLFGLSSFYSDLMKGVGAASRLFELQDRKPSISPTVGIPITSARGTIKFENVCFSYPTRPAVAIFNGLTFSIPPGTNVAIVGPSGGGKSTIGALLLRFYDPTSGNITINGVPVSTMNLKSLRRRIGLVSQEPVLFSGTIAENISYGKPTATGSEIINAARKANCTFISDFPDGLETRVGARGAMLSGGQKQRIAIARALVKNPDILVLDEATSALDAESETAVNEALTGLMKSDCTTISIAHRLSTIKRSDRIIVLGVDGRVAETGSFRELSTRDGPFSRLMEWQLHGGEAPASLPRHWGTLADTGVNEGVADGVEEEVEEIEVEEDEDDNHVGRRKTIEVAVKAPGDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8M0</accession>
    <name>A0A2T7A8M0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8M0"/>
    <dbReference type="OrthoDB" id="5226202at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="124" mass="13609" checksum="5EC9C473F7F4CD87" modified="2018-07-18" version="1">MSSIAPLNTKSRSFSSSTTSSTSAPASPTTTTTSSSSSNDSHAQKLLEKVKSFVPHHHHHQSKKPYPQPPTDVSQQPQHRTSTDSMHGVERRPTVTMYGRHSNEWLFGGVSVRKVVGGLFQHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Q2</accession>
    <name>A0A2T7A8Q2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1682-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1118387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Q2"/>
    <dbReference type="STRING" id="42251.A0A2T7A8Q2"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU84082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48638" checksum="37EA5C36D7ACA252" modified="2018-07-18" version="1">MAQKYLGKILGDEKKKAESSIASDDDFADFATPSPATPPPAPESAAASSLTSISASPTPTGPPIKFDGPWYALWERHSLGEFQFEGYILLLLLGVLGWHLWGTRRNRAIAKKFFGNINPVLCQEFAYVGFDPYSQANTGQVVTADYALKENHPLEFITYASGRQNVAFMHTTIKLQRRSNPITWFGEHLFAFFFESIPTPTDNATITISPFDGQDSGKSGLSSKYDSFVWALVNKNHMKRWREDRYDLSLTRTSDWDGLPNWLAVMSESKEIGDTVLTKELKEAVVDCQDILEYLIVSDQPIDKPTTLAETAPKKRVILQVNIPSDTAPATLPKLLQAFIRLVDHLAAVAHFRPEVLRKVKAVREDEAKKLQKQVDEEKAEERQLKRDEDKKIEREKKLHGMSAKEQKKFLEKEREKETHKAMKRQTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8S5</accession>
    <name>A0A2T7A8S5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8S5"/>
    <dbReference type="STRING" id="42251.A0A2T7A8S5"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="10617" checksum="8B4BF42B7FCBE912" modified="2018-07-18" version="1" fragment="single">FHEMLSNREATRYWSTLPHTTLSETHTWITQSTTHTHDYAILLKTTNEVIGKIGYFGPEIGFLLHPRVWGQGYASEALGGFLQVLWEGEIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9K4</accession>
    <name>A0A2T7A9K4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1013991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9K4"/>
    <dbReference type="STRING" id="42251.A0A2T7A9K4"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU84403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="37962" checksum="C1A1CF13FB4B6A42" modified="2018-07-18" version="1">MSTPVPDSIPSLSIPTSSITTTAATSISELSLNDTYTPRYIDVGINLTSSVFRGSDNGKQYHEDDLEDVLQRAKDAGCQKLMVTGSCYDESKNGYELAQQHPGLIYSTVGVHPCSVKLIDSHPSGPEAYLSSLRTLAQEGASSGYVTAFGEIGLDYDRLYHASKEDQKKYFALQLDLAEEIGLPLFLHSRAAAADFEDMLFPRLPRLSGGLVHSFTGTVDEMRRLVGAGLYVSVNGCSLKTEENLEVVRQIPLERLMLETDGPWCEIRPSHASYKHLNKDECPPVPKQVRRDKFKKGFMVKGRNEPCNIPHVAYIVAAVKGVPLKEVCEAAWKNTLDLFGMGKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9N2</accession>
    <name>A0A2T7A9N2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polynucleotide kinase 3 phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9N2"/>
    <dbReference type="STRING" id="42251.A0A2T7A9N2"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="431" mass="48354" checksum="7BDAD94C23D60D2C" modified="2018-07-18" version="1">MPVGGPKRRRSADGSAAPPAKRKVQSTTTQATVVNFFKPASKKEPEHTTWKVVDDTLLVGTYFNRASPNKTKPAAPDEKRRVAGFDLDSTLIKTESGNVFAKTATDWKWWNSCVPDTLRKLHRDGYVIVIFTNQGALKQPKKESTNLTKFKDKIAAVLGSLDIPLTVYAATANDRYRKPRVGMWEEMVDDYDLDAHGVDLDASYLIGDAAGRDGDHSDSDRHWAANVGIGFRTPEEFFLGEVPKSMTHRFDPLEYIKSEPQALAFTKFSKQEIVLFVGSPGAGKSTFYRRNLEPLGFERVNQDTLKTKDKCLKVADSLLEDGKSVTVDNTNADATTRAAWVSLAKKHKVPIRCVHFIAPTDLCQHNDAVRAFGGELVNPEKRTILPKIAFTSFTSKFIEPHIDEGFHDMTKVEFQWEGGDPELQIWRKYWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9K3</accession>
    <name>A0A2T6Z9K3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000701">
        <property type="protein sequence ID" value="PUU72163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9K3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="102" mass="11357" checksum="A72B0046010C91A6" modified="2018-07-18" version="1">MPAKNGSKRNSHLVHPAGSDLSRPVRPRRGEDDKGRDCLVLDGVDGRRRPSTTDAQNCGARAACQGWQSDRRRTAVGRPWRRPVQDEDDTVRLPSTAVRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9Q4</accession>
    <name>A0A2T6Z9Q4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatase activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1104460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000637">
        <property type="protein sequence ID" value="PUU72227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9Q4"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9Q4"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF16">
        <property type="entry name" value="GROWTH REGULATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32410" checksum="9BB5D2018ACF7651" modified="2018-07-18" version="1">MATAGGSASIITQVQQGGPSLTTLGDTASEENLTLDLRGTQFLLSRDELLTLPEFVLLSLFPNGLFPDGQVNSFHDEGVHSVDFDPVCLQYMLDFFRQVSSTITSSNSGPDDADAENGASPSSPTNVLQDRAGIIVLREDLDFYVIPPRRDISHPDMISVKRNAGKVLLKQDGIFSGLRRTDDAGTTEQHLIEMLTAGGFNTDDRWGHRAGEPNKAVICSLALARLRTDMRSATGDGKDSTTVGMAQKLLLFWRKPARRCWWEGMDLEGVEGVDGKLKVWIRRVWTLEMSVIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA24</accession>
    <name>A0A2T6ZA24_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000565">
        <property type="protein sequence ID" value="PUU72348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA24"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA24"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="19496" checksum="1608DC91FF755230" modified="2018-07-18" version="1">MGKPSCPFRCHPRIVRVHRYNKHLRQCSSRALQTKLFASPENSRKPAVTHGEYVNGIRSQKVASMYSNPDYALGEFNAIRPSAWRPEAKVNLLSISRELAYRSKMAKRFSQFAAASASDGSVDRALRKLSFACDAAEKVLSAVNRTKKISGKRLWEFLRNYLSKYEKANAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAN0</accession>
    <name>A0A2T6ZAN0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000509">
        <property type="protein sequence ID" value="PUU72548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAN0"/>
    <dbReference type="OrthoDB" id="5417691at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="28561" checksum="D3C43A841CF9021B" modified="2018-07-18" version="1">MAPNMRACSECAAQKKRCDHKVPVVPLRKNDGLRRKQRSVEPADEVMLDAAASDHGTKVNKRKAAQVEEVVPEAVRNVRRRSLRKGGGNGRHISEGSNAGSTEEGGFPEAPNGLPQNQGEKRHEDLSSVPGGDPHNESLSPASVSPPAIEIASPTPSIAPEVETRGPSPLADDTEEEKNSVRPPPAPSPPPTRSQLPSSNVSPAPGSSPSTPSTPSPQQAPIRPHSRWVDPTKPAGRFSGARRYTPLALNTDIYGGRIPPPAPTPPPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB53</accession>
    <name>A0A2T6ZB53_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_629475</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000475">
        <property type="protein sequence ID" value="PUU72727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB53"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB53"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="14">
        <location>
            <begin position="547"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="346"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU72727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="678" mass="76045" checksum="B5E8B8E96705EAFD" modified="2018-07-18" version="1">MSARKLQQEVEKVFKRVSEGIQSFEQIYEKLQHCNNASQKEKLEDSLKREIKKLQRHRDQIKTWAANSEIKDKKPLLDERKKIETQMEKFKAVEKEMKTKAYSKEGLMASTRLDPMAQKKHDLVTFLSDCTSDLDRHIEACEAEAESLSVTLKKGKKDSSKAERVAEVEKQVERHKWHQAKLELIMRLLENGQLEVESVERVKDDISFYMDSWQDVDYPEYESENIYDELDLDEENAEDLYGIGADADRMSSQETQSIQDDLSERPGSTKDSVTGGRRPSTQLKSPMPALATLHQPASSAASPYINNGLPPSNGSMKPAPLPTRPAGEVLKYASVATAAAAADRNVGIAPLPPPASMAAQASAASSSLGMSPLPPPNAPKQSSQRQGSGSGSLPAPVLTTPSLPDRCQASVPHTPPIEAAVAAAPSPKPSSVSTAPPVSPRNQQEPAKHEEPAHTKNSRNVPTSEPESSRSIPDLSPSPLPEPQTNVTNGSSMPSIPSPGPEPSPPPAEESVYYLPPGLQDLMSSFENTKKRLLPQPGSLHRSLEISMVSAPDTIDAEKPRHYKPTTKYNTPAHYPQEPLPVFDDPSLYKRIDVDTLFYVFYYRQGTYQQYLAAKELKRQSWRFHKQYQTWFQRHEEPKTITEEYEQGTYRFFDYESTWMNRRKTDFKFAYKYLEDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB76</accession>
    <name>A0A2T6ZB76_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1096669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000474">
        <property type="protein sequence ID" value="PUU72741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB76"/>
    <dbReference type="OrthoDB" id="5415177at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015483207" evidence="2">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="193" mass="21627" checksum="F23A093B5B99D2B6" modified="2018-07-18" version="1">MPALLTRSLTFLKLSSALPKSPAEEDRASTACEIDEFLRCLPPSPPAPPPTPPYHHTSHHSPNPSTSSNLSVSAIILPPSPPPTDVPPVPPPSYNSLERGYYNSSVCVSPLSHVHVHRYDHIPESVYAQDGQQVQPHHQRSSSREKNRLLNLRVETNLDFGRRSEEPVLVYQAAPVEEPRRMRQEEIIQCNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBP7</accession>
    <name>A0A2T6ZBP7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1096334</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000446">
        <property type="protein sequence ID" value="PUU72903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBP7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBP7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13986">
        <property type="entry name" value="STKc_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU72903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="42668" checksum="6A2463BD0E698C5E" modified="2018-07-18" version="1">MAQYFLDLVYSLTTCMSCFPSSPNLTINHRSFKILRLLGEGGFSYVYLVQDNAGDLYALKKIRCPFGQESVQRAMKEVEAYKLFNHENVIKSIDYTITSDRSASTTLGRSDDGDDGSQKTVYILLPYFRRGNLQDAINANLINHTIFPEGKLMRLFLGVCRGLQALHEHRLKRPGEVRAGAGAGASAGGGSDETTEPLMTPDVLSAQEGGQEGDIRAYAHRDIKPGNVMIDDDGLRPILMDFGSMTPAPTPITSRTLALSVQDNAAEHSTMPYRAPELFDVKTGSVIDEKVDIWSMGCTLYCALYGHSPFELATEESGGSLALAVCSGSYAFPEEGRLGGRKPGQRPVSEGVKEVVRMCLKVEPADRPNIRELIREVEKVIETLGDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC42</accession>
    <name>A0A2T6ZC42_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_578639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000417">
        <property type="protein sequence ID" value="PUU73067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC42"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7267" checksum="903AA1E6A361C87C" modified="2018-07-18" version="1">MGVCVWGGGDSRVLRILDLVALAAFFFFLFFFFSSQDSSVGGWLWCNVLLFIVIPMVFTCGVISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC95</accession>
    <name>A0A2T6ZC95_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_912851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC95"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC95"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="9027" checksum="0E54A81DB9606F6F" modified="2018-07-18" version="1" fragment="single">VRDRDRRCVITGVGEGRAQAGWWTGLEACQVFPLAVESHWNGGDYGITMHPRSGGSINLVQNGMLMFGGIHSVFDRYAFSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCQ4</accession>
    <name>A0A2T6ZCQ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1135507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000394">
        <property type="protein sequence ID" value="PUU73272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCQ4"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1642"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1438"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="992"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1673" mass="176498" checksum="83D8963E509E015F" modified="2018-07-18" version="1">MDSTPDSERPPAPLLDHITTDPHEDSYTDSGDPTKLKNAKNIGTTTPEVEGEDNEPVTTIEDYPSTPVSTMDPLFQSLPLTGESREDSTPLPPTPEEPEFRVSEEAETTSLSPPTETEEKQSDGVEEPKAEVREGSDMGSKPAEGEEVVEVDEKVEVPESSETKQEPSEVKAVDLETGEKGLETLVEKMEEGSAPEAANLKILEPNASEEEPSKGAPGANGEIATAIDETPAVLNASDFSTEALRTAEPVEGTDDKSRDTPAAEVAEDVTEKLSSDIIDTKYRDNSEPQNIQDSEPAIDEPKAEEAAYGGEGDSEVQQEHEAKEAEHPEVTEPAMGNTDPNTKTAEHTPDAILEAVVEKREDGEVRPKAGETDTTIGDHESEPVSEAVPVLEADSVPSLEKSSVAEGPGMAQSETIDLEAGDALEPIASPETKEAEETRPEVTGAADAEPEEEKLLLEKSTEVAEEPKDEVEDEPKEGLEALKEESEEEPKGETTEATEAEPPTMEVLPLAEPPKEEVSISSAAGQDSPDSESAKELAGDAKEESETNELVEPEPQAAQVLPVTEPSKEGDDSPSVEADPGAEPESTGESKEDMKVETEHEVEEEPESGATEISEPVKADPAVPDALLTETPEEEVPSIGVEASPQSEPSEEPEDRSEVFKAEPLEGLDGETGNSTSEELRAPEEVGAPASMGAPLDDGSGQELEGAVAAEPDIPKDKEQETQEVVQVTSILDKAKPEESEHKPADAENSPAADVKEVAPVEIYEGNDASTVSKTEIGGGISADAGPEAPIGESEEATKSEPITGLEPKEVFTETLVEEGKLSELAEVPTVVVEKTIENQPSYGEDLGPDATEGQKEAFEMRKADAEPDEVIMTEESPTPQIVPVEENTFESTPDDSGEAPSEPMDEIKAEPATNPAANEKGEDLAQDEPIVVSHDDAPPGEVEKAEAAVEYPRPDPQEAAEAPKEAEAAEDGKPPVSPEQKHDDELEGEPSSVEELVAVAAVVTGETTVSGTDDNKDLPGETSTGPVPASGSFSDPASTTGGNKAQVQTEPEATDEVTEAAAGSSPLDEPQSFETPSDIVAEHVLAPRTEEPGVMAPTETSDKAEEPTSSKELEEASVARGIAHSVEPTREASEENVVDSSVGPGIKLDQDSCEGVVTSSPTTLEGTQQVVKEEASVQEPEEKEQEFSVSPLPASQTIGNPIDLAPGEKVPVEFKVSTEDTVQAEDNPSEHASAKPSEIPLPVTGDVKPTVQPEAPAESRPEEQIFSINPLPDSKTFGNPINLRPGEPIPICLTEASVADNVKLDEEMFKKPEDKAPVAEEAKAEGSDGGTGEKILAVGVGAGLAGLGAYAAVRHFDDKTEASKHSSEKASPVASKYMDQALPKYFFNELAPASPTDPEIGGRSPAIDASAKPIPSAAQEQVLPIEVSFTTPAIPKELSESPVVSKTEIEPAHPADGSTEEIKPAGTEVLDKAPLQASAIDIPDDSAVSQSAGKSGSDEGDEVILEPAPQSAQSPVHGLVAPEEHVLKALKDAEASETPAIVVSAPPNPATGSGTAEVIQPSSSEVAFDEVSANKARESGEIFAHPVWNQSVSPLLQYSLENTPEGVRKRRAPGAGGEVSRPTSSGADTVSTRHHRNIMNGFWHVVLFGWLRGFGRFFGGIFSKSKSKKQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCS3</accession>
    <name>A0A2T6ZCS3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1005379</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="NESQ01000394">
        <property type="protein sequence ID" value="PUU73269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCS3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCS3"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="15">
        <location>
            <begin position="468"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="270"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="570"/>
            <end position="572"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU73269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="615" mass="69158" checksum="393C2458CF27F70A" modified="2018-07-18" version="1">MAPTKDPNTLSNHLEFSTAHTAISLTLSFSKSSLYGEVELTLKALADGLKQVVLDTSFLDVRAVAVNGKGAKWNVGNRVEPYGSPLKVDLEKAVNSQDEVIVKVTWDTTDKCTALQWMTPEQTSGKRHPYMFSQCQAIHARSLYPCQDTPSIKSTFDFSIRSPLPVCASGLPTGVHHFVPATSPSEPGTLAYTFRQPIPMPSYLMAIASGDIANAAVGPRSLVYAGPEELLRCKRELEDDVETFIKTAESLIYAYEWTTYNVLILPPSFPYGGMENPCITFATPTIISGDKSNVDVIAHELAHSWSGNLVSNASWEHFWLNEGWTTYIERRIQGKVHGDKHFHFSAIIGWKAFKESVELFGADHEFTKLVIDLRGKDPDDAFSSIPYEKGFNFLYYLDRLVGRERWDAFIPHYFSTYRRKSLTSFDFKDTLLSFFSKDSEASAALAKVDWDTWFYKPGLPEKPDFDTTLADACYALAESWQALNSSNSSFKPSPSDISGWTSGQIVVFLERITDFSTPLRKDLVELMRDEYGFLKSENAEILSRFLTVGLKAKDEKLYGKTAEVLGGWGRMKFVRPLYRLLNECDRELALKTFAKNKDFYHPICRGVVMKDLGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDE4</accession>
    <name>A0A2T6ZDE4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor TFIID-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1094922</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000370">
        <property type="protein sequence ID" value="PUU73518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDE4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDE4"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="137" mass="15623" checksum="EEDA845EEF6DAF71" modified="2018-07-18" version="1">MRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHHFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYIAFESIYPVLNDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDW4</accession>
    <name>A0A2T6ZDW4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1111067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000354">
        <property type="protein sequence ID" value="PUU73691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDW4"/>
    <dbReference type="OrthoDB" id="5355583at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="267" mass="30111" checksum="D783A08E91266415" modified="2018-07-18" version="1">MFRRATKLAFKPAGICRYLPHVRAITTTAPKNGKTTTTATTKLKYQKAYSKMNTQETEERLGLIFKKFERDAVSISQMLADAKPEFKGLGEEQVEGTKKKIFNNIIDLINVEGYPSEANDDFNKANVNDLVAFILPIVTAFQRGTGRELRLQRERDIITTNFIGNGDHKFAFVVEAQKAFIGQARRLCMLALKEMGDNNPGGVLYGFVTSGDCWRIIRYQGGIFTQTDPVQVVFRTMEHEKEKWLKESSIIVDFLHAALRSGGFVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFE5</accession>
    <name>A0A2T6ZFE5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_471398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFE5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFE5"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="145"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="481"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1124" mass="122534" checksum="3ECF750067E40A38" modified="2018-07-18" version="1">MALVSTMDHLHHRHSQHSSSAPGHPEQQQRHQQSLQALQPGQYQLASAVFRIDPGLELPQADMLTHQRPLQSQSQGQSSSSTGFSPDMNPQQVSGPGGLSAQLLTSRAPTIESQIHIQYPPPNLHQSHPSDPNPFLEIQSHMSLHHQSLRPMSNPPHPPSPIQSTHQQSHQQHPRHAQQQRQAPTALQPMPPSTTGGQGNRMVMPTLGSSGPIQGAGVGVPPNRSRVGMGSEVLATPGGESRVGEAPPVTLPGNGQSSGRVSSGHAGITPGATSQITPVKDQDGKFPCPHCPKTYLHAKHLKRHLLRHTGDRPYQCILCKDTFSRSDILKRHFQKCSIRRGNPTGATHLSHAHAHQQGRRPNHHHAPLPSLPAESLISTPIVAPTEGSDKFSPESSSPGSCDQCVRLKVRCDSGSPCEKCRMRDGGECSYSGVPRRTDSGSEIGVMSMPELSDSLTSKSQPVGYGEGFNFPPPTHPHAHMAHSGQHSLSPLQRQSQPPDSQQHQQQQSPHQVGVSQSPADPFYNNGWENLMELPEQQFLPFYLPPSTQPPSSGIITSAGGMGQSLQASDQPVYGMYFPSDLTDMPPLGASGGVFGGWEMAQQIDPLQAKCDQLIAICFPENPGQGSSSAGLPDQGLEPGPTAEDLKEWLTPDHVKHFVRLFFINFQGHFPMIHLPTFNMLTIADGLLLAMICIGAVYSDRGITAEDVRAMIDRSFVALDGTDHSLSDGSQGSTSWQLEEIQARYFLHVLSAWHGTFRQRESTRRSYGTVIAKAQGAGLFRPFTPNNLGAAGFSMCHQVGDHQLSSPAGWDWTSWVEQERRNRVMFGILLLDTAYAIFFNHPPRINLHDIKLTLPSDDAAWDAPDAQECANALGLNGEGPNSNNIAGSRRVQQPEFMATVNALLEPSQEFKPGTTNAYSKFILIHALHSHIWVTQQRLPNATEMGIGQAIGSMADPSVEWGSEGNVLSANGGSSGRGTPEGFIDNALIGDQLRPSTLSEATRAVRICQYSLEKWKKAWETDLHSQFPLPAARVGFGRDGLPFYWLAKLYLARNRTTEWRHGINDDRTVAKVKNMLKHVRGFIADDTGRLDLQGAVSAIDDGYAMDELTYDMKLLFRPIGTDSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFN1</accession>
    <name>A0A2T6ZFN1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1093359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000314">
        <property type="protein sequence ID" value="PUU74224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFN1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFN1"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="57"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="376" mass="42321" checksum="D0337871746AC6D4" modified="2018-07-18" version="1">MPAATNHRNIVGVNAETVTNVSSTDFPGHWPGEDHSWNIKHFRRTFRVKFYRNTPLLSQFDLIHTDAAIANTLRRIMIAEVPTLAIESVYVSNNTSIIQDEVLAHRLGLVPLRGDKDALKGLSWYLRGEDSAPREPTDEDTIVLHLKKTCERNPDAKKTDTDPDKLYINHNVYASDIVFEPAGRQIKSFAHDPIRAANPDILIAKLRPGQEIDLTMHCIKGIGQDHAKFSPVATASYRLLPDIRIKKPIRGKAAERFAACFPKGVIAVREGEDGEKEAVVDNVRNDTVSREVLRHNEFKGIVELGRVRDHFIFSVESTGQFDADEIFLSAVGTLKAKTINLKRDIYKMLRKQALDAKRAREAENPDADEEDVMDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFP2</accession>
    <name>A0A2T6ZFP2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1116984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000308">
        <property type="protein sequence ID" value="PUU74289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFP2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFP2"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="26944" checksum="7DBEDB3AD8F4BE58" modified="2018-07-18" version="1">MAQRKGRGRGGGGGGGGGGIGGPFGHDPDNPPDYSTTELFPPQPPPVPNPLSKEERHIVARYRLYREKIHNGPLYTVIGKESGMEDPFNVSKYSARYKPQKRGVPQLDSRPYVKEFFPRELWQTLGIDGDGDAEGGGGKGKGKGKGKKLIFSALDVIGGLDEEDEEDGEGEDGEAGGKGKKGVLRRLLGEDAGDDDDGDDDDEVAEEEEEVEDDFGDDEEGDYNAEMYFNDGDDDGGDDWGDEGGGEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG17</accession>
    <name>A0A2T6ZG17_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000299">
        <property type="protein sequence ID" value="PUU74440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG17"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG17"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="331" mass="37021" checksum="88A78B7D8BD650E2" modified="2018-07-18" version="1">MATLPVENMGAPRTPSPPPQPLGYPPPGPKLGFSQPSSLASAHLSPQPSALHDMNYYLAEGLQSVERQQFRDNKSLIRAIDSQVKKLCSGKAGQYLVFAPVTQDQFVAIERMRQNHHKGIRFHYFNREETLIVKVFAGPVQALVGCGFRTRLDVKIGGMGLVSYIFGMDTATYKGNRSQKQANIDWKPWSPHHGAADWPTVVIECGVSQSRDRLEVDANCWFENSGGQVKIVFLISFSEEKKEIHLQQWKLVTAPDSHVSQARPPATSTAPTIVCELDLASGVPNRESLMLNFERVFLRPPAQGEGYRERDITFSPEELEEYANHVWNHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG29</accession>
    <name>A0A2T6ZG29_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1103448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000299">
        <property type="protein sequence ID" value="PUU74443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG29"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG29"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37836" checksum="5C2C1E5048E6F515" modified="2018-07-18" version="1">MTLQTIFKALAAVGTPYRVSVAALPAAKLPSLPAKILSIGTSNYTTINNDYYWYMFITFPASSVVLYPSCIVSRTSPQKVSPAVKNFTESLNELILNKENSYGLAIDNVKIYEVVLGNGTIIHANATSHSDLHHALERGGDNFDWIWGGMIYYNQSQLSQVDGVLYDYRVDIAVNDVKAYILPQFVLPHLYNGALNFTSPTLQPWVVDLAREFEAGFAYGFVQRTFTVYKEKQFFSDVELILMFNILVLGLIFNNLSDTDEVFPAFATFIESMMSLAKQRSVRHPYIMWSYVGHDEGIIEACGEGNNDFLRRIKEDYDPVGTFTNLVSGGCKLPAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGD1</accession>
    <name>A0A2T6ZGD1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000293">
        <property type="protein sequence ID" value="PUU74532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGD1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="9281" checksum="4FDFF435E664D225" modified="2018-07-18" version="1">MTLSQAYLPAYLALPYSATALPSDTDSCRARKERTNGGNTMHPFPLRSGCATDHQHQHQHMYLYLSHRSVVRKPSQKPKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGQ6</accession>
    <name>A0A2T6ZGQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1132845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000282">
        <property type="protein sequence ID" value="PUU74662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGQ6"/>
    <dbReference type="OrthoDB" id="5383338at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="612" mass="67688" checksum="E95B936211DD8565" modified="2018-07-18" version="1">MSNHYYEPVAGSPGTWSRRVPTSTSNGYYTPVSTLSSRDSSGSVRGNHSGGAPTPKRESPPMPRFRRMETLPTTGHRVSPPTLPPNGTPVFKRADTFPLIIHQDSPRASFQARREVTLPVYVPDPPPTPPYSAPSRSSKRRSQLSSRSQSSTTSRSPVRIIQGDRLSLVRSPSPIEIAIPPPIVREKPIYSPRHSYRESGASVISPLPATIYVPGEGDEEDELLPEREEDIYELHMQRPNNNRVYHTPPRSTQSSIARMSSFQAPSSPTSHRLDTLDTFLPPRRALSYGEPTQADLVNLWSAAQGAKRIPGTQNGAGKTFVLKMYRQAPLEHPNPVQHSLSFPEHFTFGTSPNNPFYALYAMRETTQDETFNELTLLRRDPTTGMDISVITLGLEPPSRRISPAGDGLITLIYPKEAVLSAMSPSTPLTRDGNTGFLAMGPQSKTQETRAKEAIQKAYTTECCRLSWNAQRRRYYLYHPGVAEGGDAYLVDITGEVGFDHLGAKGNIKLINVDTNETIVELDFARSLLFVNTRATGKIPNDYIVDVAVCAVLTVATVEGRRMRIVRRSQSSSSTMSGLGKWGDESSIDEGEREGCWGSMASWFGKVFKKRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH89</accession>
    <name>A0A2T6ZH89_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_395815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000267">
        <property type="protein sequence ID" value="PUU74860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH89"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="139" mass="15781" checksum="31AA412E029E4E5B" modified="2018-07-18" version="1">MDVGGIMILFCFCFCLRPVHRRVMVAGCVLVDGVEGGFLLLVPWLGGLFLKIAVFWPDARALRWGYYASRGWYFPDVLRDRQVGLAYPGIVMPFGAHKPGLAVAPLVIGIKYIETTDRFHYQLCLYLARVPENERRDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHA7</accession>
    <name>A0A2T6ZHA7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1132466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000269">
        <property type="protein sequence ID" value="PUU74836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHA7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHA7"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="3">
        <location>
            <begin position="302"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="611" mass="67875" checksum="EC6C1D652864E02B" modified="2018-07-18" version="1">MSQQNNMSRNRSSSSLSFNQENSSFNDIDAFIDYDGPSSFMPSPTLSRSSFSSSQSSSTPSMNQKVTGSNHLSATGFPAPSHQYDLHTQQTGSLPVNSGFYPDFFPPTASMSVSPHENNFMQLDNDSSASLNSSNGMMPAYFYPESTTAGESSANFVNPSLVLGASPMMDNLESSVKIEVPTVTVPPVGPTAPPMATAGRFYAGIHQHQAAYEQQQRAIREQQQRQAQQQAPLSQQQQLKVAPKNSVNERVDKILTSMKSNAPHPSANGTPAVLPHIAKLKKEEDEMDEDERLLASEEGKKLTSKERRQLRNKVSARAFRSRRKEYITHLEQEVATKTNEATDLQHENTRLREENNKLSELTRMLLSSPAFSVFLDAMQPAAQNDTLDQVPNATTAPEPKTVPSNNDSSLRPNTRKDVNPNLAPVSEDSEWPLAYNTWGTNSPQVFSVLELPQGPPSIQDLNGKVVEDEDWKLNSLPVADGFFPVRNEKADIMDYHFEEEDEYEAPEDLFDVYEEEMQYYTREETEVDEKKTLDELFPGTGVEALLERLEMIAGGQAQPEDLFEEAVAEESPEVVEEKSEEIEESTLGEANRMLDAAEGIYRRIGLVVGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHP4</accession>
    <name>A0A2T6ZHP4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_895904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000257">
        <property type="protein sequence ID" value="PUU74999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHP4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHP4"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="8889" checksum="8AD39D7566D20896" modified="2018-07-18" version="1" fragment="single">ITDGQVQAPQKRSILRVRQNGDPLQVTLKGGVLTDILGRIGYIADNHQLQFDAPPQAGAIYTAGFSACPDGTLALGDSNVFYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHU7</accession>
    <name>A0A2T6ZHU7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1110277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHU7"/>
    <dbReference type="OrthoDB" id="5454865at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015762067" evidence="1">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="133" mass="13677" checksum="81E290BA9FAFCE0A" modified="2018-07-18" version="1">MQFTTLISAFVFAAIALAAPTPADPAPGAPTPAVDSSMETKTGATTWEFHPFLDASCQTSTGNTLGGSQAPGSQCINVTQRYGDKVYSAASTQGCKVYVFLNGNTDCSGTPEPAASNTCSPYPTPISSIRVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI52</accession>
    <name>A0A2T6ZI52_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">At1g04190-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_939911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000249">
        <property type="protein sequence ID" value="PUU75136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI52"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI52"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="7388" checksum="5BE7170D66F8D9C8" modified="2018-07-18" version="1" fragment="single">REFSAAYALCTQAIHLNPTSPTLYSNRSAALLSMNKLPLALNDADQAIKLDPTWPKAYRRKASVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI63</accession>
    <name>A0A2T6ZI63_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000247">
        <property type="protein sequence ID" value="PUU75169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI63"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="26807" checksum="DC25453E973F4051" modified="2018-07-18" version="1">MFGDFAEPISHGKAARVTGIYSPTNPVPIPITENRNEEELYDKFFREKNMEQEKNRKNQYQVFADRRDERWREKNDELHAEILRLNMKVQKLEGLLETEQRMNEKLDENINIRGGLERIDYAGRQQGKIGSKVSKGPRAGLTAMIKMPEFAEILHEEVEERKLVPDDIVYCIQGAYNTYSERVHGNNGHLVLRRRDHSANQIAALVVILRMQEKWANSITWTEVEEPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZID2</accession>
    <name>A0A2T6ZID2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000244">
        <property type="protein sequence ID" value="PUU75216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZID2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="94" mass="10056" checksum="45598F5D52FB28F8" modified="2018-07-18" version="1">MNAATKSPDHIFVTCPVPEVVAAMEDCFRRYLCIEGAIERDVASGAEAWDAKESVLICDRVLVAWGPSYAVSISMCAVVENIAIGGLGVLLHCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZID6</accession>
    <name>A0A2T6ZID6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000240">
        <property type="protein sequence ID" value="PUU75243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZID6"/>
    <dbReference type="OrthoDB" id="5497736at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="296" mass="33946" checksum="6BD027EE3224C6E5" modified="2018-07-18" version="1">MLRCSLWLFRNLPEYTGCPVFHSNKLVVYLTPEKAYDYVGKESVVIVEDIQSESVEGGGSGGSRTQSAALLQCFDTNTSTKKQSPNRQAIEKDLLYLYLVIAFEVGGDLYVLGTMLILMKNQFLEGVRTVAPRLYIGSYHNIQLVANEHSPTEGNMYRSPYAEDSWNLSSEIIDWCNRLLSLYRNNFCKRLPGLRRLALVLYGPTRTGKTECAWSLGNHIFFSGRFKVLRYRDTYEYVVFDDVEFSCLDVVKFWFGNQLEFTSMDKCCKKTKIFHSQPVIGFFNHDSHLASWADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIN3</accession>
    <name>A0A2T6ZIN3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIN3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIN3"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="335" mass="35696" checksum="E52EDACF35A9D29E" modified="2018-07-18" version="1">MKGIQVSAYVNGPEDLKVVDLPDPTPATDEYLIQIRASAANFFDLLQIRGKYQNQPPFPWISGMEFAGTVLAAGSSTKKFKVGDRVFGAKQGAYATKVCAKEPVLHPVPEGWGFEDAAGVYVTAPTSYQGLVGRAGVKKGDWVLVHAGAGGVGLAAIQIAKYFGAKVIATASTDGKLGVCGKFGADHVLDYSRGSWPKSVLEITGGKGVDIVYDPVGLVEQSLKCIAWNGRILIIGFAGGKIEKVAMNRVLLKNVSLVGLHWGRYTEIQNEAGTIEDVWNGVLGMIKDGGFKPTVYRGEEFVGLESVPRALKALGARETWGKVVVTVPKEGESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ97</accession>
    <name>A0A2T6ZJ97_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1053738</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ97"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ97"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="234" mass="24734" checksum="8F8DABDA5498FAA9" modified="2018-07-18" version="1">MGLRTMDIHTPTIPSSSTIANAPVSPADPPQTLEGSKASLMALISRRDALEAELKALGSVLDSHRVTMTTPLTTFDGYPRDDIDVAQIRITRARIIPLRNDYKALTAEIERGLHELHALSASLPTGVAEGIIEAPFARVNTVEPAGPAGIAGVRVGDLVKRFGNVGALDGASGAGGGDALARVSGEVKRFEGRVLKVLVSRRDNDGVWQNVNLEITPRADWGGRGLLGCHLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJF9</accession>
    <name>A0A2T6ZJF9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000222">
        <property type="protein sequence ID" value="PUU75613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJF9"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="221" mass="25126" checksum="6EAFBD277CCC2504" modified="2018-07-18" version="1">MAPRIITLVRHGQAHHNLNQNYHLHDPYLTPLGEAQCHKLSKEFPSEPLVDLLVSSPLKRTIQTALLGFKKQAESGAKIELLAEIQEADGFPCDTGSSRDDLEKEELFQGLDFSGLPDDWTLKKGKWAPDPHSVGERARIARKWLKSRSESHVVVVLHGNFLHYLTEDWADYDNLQGTGWRNTEFRSYVFAEGDEDNASVIETDESKEKRKGVKNHQEGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJQ3</accession>
    <name>A0A2T6ZJQ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000217">
        <property type="protein sequence ID" value="PUU75715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJQ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJQ3"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="69"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="414" mass="45679" checksum="AC397862DA919DEE" modified="2018-07-18" version="1">MAPINVLMVGTGEYTTGWVGTGGSTSDKKIGVVGLTLFDLRRRGKVGELSMVGVNGKKYPDIRNHLEKNIKNVYNNLDVSFKSFPADNAVDPDSYKTAIDTLSPGDAITIFTPDTTHFPIALYAIRKGIHVLITKPATKTLEDHLTLIKEAEKAKVFVYVEHHKRFDPVYSDARAKAKNLGDFNYFYSYMSQPKFQLETFKAWAGKESDISYYLNSHHIDINQIMVPGYRPYKVTASGSTGCATDLGCVGGTEDTITLLTDWVKKDDPSKTATGVYTASWTAPQKAGVHSNQYFHYMASKGEIRANQSKRGYDVTDDDLGGLSWYNPFYMGYAPDEEGNFGGQSGYGYISFEKFIDACTALNEGRITFAELDRRGLPTLKNTVVTAAILHAGRVSLDEKRSVGIEVAGEVLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKF0</accession>
    <name>A0A2T6ZKF0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1052900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKF0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKF0"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU75953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="337" mass="36297" checksum="52F8F166ADBFDF16" modified="2018-07-18" version="1">MVAKVGINGFGRIGRIVFRNAIERDDINVVAVNDPFIDPKYAVYMLKYDSAHGNFKGDVSLNGSGDLNVNGKTVKMYQEKDPANIPWKDTGAEYIVESTGIFTTTEKAKAHLKGGAKKVVISAPSADAPMFLCGVNLEKYSKDIEILANASCTTNCLAPLAKVINDKFGIVEGLMTTIHSYTATQKTVDGPSAKDWRRGRAAATNIIPSSTGAAKAVGKVIPELNGKLTGMAMRVPVQNGSVVDLTVRLKNGASYDQIKKAVKEAAEGPYKGIIAYTEEELVSSDVNGHEASTIFDAKAGISLNENFVKLIAWYDNEWGFSCRVLDLITHVAKVDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL14</accession>
    <name>A0A2T6ZL14_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1130122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL14"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015761192" description="Major facilitator superfamily domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11814" checksum="971BF80119098140" modified="2018-07-18" version="1">MYLLFSFAFLMLLGNLYVSLGYVQEHGENFWIVSSSIGAGYGAVFCLAPTVVSVVWGTQNFGTNWGIVTMTPAAGAMVFGSIFHCDVESFGAFVPSQELHEQFRTLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL36</accession>
    <name>A0A2T6ZL36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1150467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL36"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL36"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="448" mass="49956" checksum="3EE62EF0328EC0D4" modified="2018-07-18" version="1">MDMAQSDLVEWYKLETEFFQDHFRHTRYVKEKNTHKKVKEDWSNCGELGTGGFSVVYKQVLGTTGRYRAVKTIDKKRLPPKLDYYRELLIMAILAKHPLLFVEFLGWYENPETLYIAMEYLPEGDLTKHIGSPLPQATVQTISKQILEGLKVMHQKGIAHRDLKPANIFVVLTSPFRVKLGDFGISKRIRPQDTTTFHTQVSTQIYGAPEVLGLDSNSKISAYTNAVDIWSLGCVIYESLVGTHLFTSWGQVSRYYHGKSPFPEDKLKGLPTPLDDVGISLLKSMLAIQPGDRPTAAGALGNAWLTGLESDDEDSGNDQDETAQSEDESNWSKGSEGKLTTHHRRKKRRGQRSPITQEDTTHAPGGSALGANPRSQWGSDPTAPESEIDTAMVISPDVAPLKSFIIQRQSINPRLRVDTSQFPGRPSHGPQGAEEKPGSQYPPSMPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM44</accession>
    <name>A0A2T6ZM44_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial PGP phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1051814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000184">
        <property type="protein sequence ID" value="PUU76558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM44"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM44"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE GEP4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="206" mass="22442" checksum="BE66AA52004CFADC" modified="2018-07-18" version="1">MAPFNLSATLNALRILKAPTLLCPQLTIPTFGHLPVPLSTALKADIRAVILDKDNCFAVPHSKEVYPAYKDTFEKLRKEYGDRLLIVSNSAGTGDDVGNAEAEVLEKNTGVKVLRHSTKKPGCYPDIMRHLTSKTDVTRADQVAIVGDRLFTDVLMANMMGSWAVWVNIGVVDPKRTLYGRVEKGLLSAIEWGGGKAPAPTGGVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM88</accession>
    <name>A0A2T6ZM88_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1088114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000185">
        <property type="protein sequence ID" value="PUU76534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM88"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="8138" checksum="7F8F2EDB6A0D2B04" modified="2018-07-18" version="1">MGFVAYCLVAATTTWCPLIPTRAPSFTTALTAHTNDPRNYPSTAGIALSISRIRQNPHPNIPSIRRGYQSQIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMM2</accession>
    <name>A0A2T6ZMM2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1109293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMM2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="384" mass="41788" checksum="423D30B0ED0CE036" modified="2018-07-18" version="1">MEETLRSGHDQNLEDCRSSDFQRMALPRRLLEQRNDQCPTEPHGNHRPDPVPPIGCRSGYGGSVNSLNPGSALLSAGSTITKKHSDNSGGSFNDLKATNTQKTYECVEWKDDLALHLRSVLPVVHGGHPQDSSWAIAGIVIFLQGQQQDPSFDMNQQPVIQNGESGRLLLFEEFQEGSCAGAGPPTMATGIGIFSQSPREPFLCINQQPIMQEKGWRSPPLSGEPQESFCGGPGSPAIAIGNDQSSQGWRRRLIAPPNGEAGVTPDLVVMHQKINPNFKPMTQVYEPVTDSARRGTGKSVTWQGALGESLSWCKLPGDGPSEMANHCGVMGGRMSVFPLLDMRWLYESAIDNVREARKFTICRSFGLSLKFYPPEGKGVVGGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN86</accession>
    <name>A0A2T6ZN86_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_204989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN86"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN86"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="18034" checksum="EE1948912D4E3801" modified="2018-07-18" version="1">MYTQARVEACDRDDLDGSREIRYPVRVCLDGGESGVMEVDGAGNGDFEDSARLAKFYSLTSTILDNIASTAGKVAYPVGISAEQASVVDHFLTPAFILGRGGTGKTTCLVYKLVGRYLFSRENVGPLRQVGGYWVSEIESCCGGVTLATLTAIGLTHEVKEISVEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNX3</accession>
    <name>A0A2T6ZNX3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNX3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNX3"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="416" mass="45256" checksum="C0A241A9082086C1" modified="2018-07-18" version="1">METYHGHVRSPADAIILFEACRLGLLPRVQRRLSEKERQNIKSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGGNAFAPPTTTLSVGGRVGKSPNPDSDSDGLDTEGPDGYRYKPDGLMKQSFSITTATHQKLHLISYYARSHPSSQNLIQPTQDSALKHIRPAKGMYPESTVHEQQNVPVVTRGPMIATNFNHAQSPGALIQRPPGATHPNSYPQQGAYGWPPSPVSTPPTNLPPPAGQYAQPQLPLPNSAASSPMAYNPPTFPSSAGSPMQYDRTPLPHLDNLPPQPSHRGSMGSPMMHIHRSPRAAVQQMQRQPSDIPMPSLPCPDQGGRFSSPASSLNGRSPPRSEKFDINPLRQSPSGGMDGGSSPGRSGLEVQDIPNEKLGFGEDVRALRVLDRAFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPC4</accession>
    <name>A0A2T6ZPC4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoporin subcomplex protein binding to Pom34-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1101902</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZPC4"/>
    <dbReference type="OrthoDB" id="102511at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="10">
        <location>
            <begin position="412"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="9">
        <location>
            <begin position="1169"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1465"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1516" mass="166501" checksum="4B645FF7A1ECA216" modified="2018-07-18" version="1">MFLLFYKALEESTSTFVVAWFTLMKDTQFLTERNFRPFPDNPDIAGAYKYAAALTPIVSLVALQYPRVEKFIQEEWATPVSSESSATPPANPGPPRGLGQVPDGNFYIKNPVGIKAITQCFIETAYNSTASIPGFCWCLILCDLLSFVNERRQEMDEMDRTGQESRNPRVEFFENVLAELFDGAAERGTKALGKATADNALEMVMLMIEPTGGRSVGPRFWIEAEEDGRRMKNVIADLLRRALHALPLSATVLGAVLLANEVQYKDLECHQAFLREDSDTSDTITGWTGSPAVRFTKNEESQKFLRRAKNRFPYEPIIFLKIMKALATVNMGVTHYLMNMDTYTQILPQGFSDYDVDDEDSDVTRIQLTNDLVVFAPRKAGFFEEEYSSRGGIVIPAGTIGEMISTGGSRPVVAWQHEYNAFPVLGRVLEQALIGDGSNSGPSHAAVGELGSGEAVTEIIGLLTILIAYGNESAPGELSPARILEEASDLVGRSRDVVSIIFDLLEAGLQAATNSSSAGKSTDFIVAAVQFVDALVPALPGRVWPYLARSTMLERHGRGGAFSGILSAVEVVRGDYEFTINCLRLYEDLVEEAIKSSVVNMGGSRSLSVASMATSSITRSGVSTAVQRDILSAWTRVVVDVFESYYAWKYINEEQKLEIGQRISRIFTKILLMVYGVDESSDLSSKITGVLAPSAQHIVTIFLSEGDNELPMEPVIRTIRVGLETPESSFHLRSLNFWVEHVVSVIKFAEVCVRTRGYLGLPPSQLEKQLYNLTAPLAKLYVIHDRYRAPVLGIFESLVAASGTIQSEPPSLLGHLGADCASHFTAVLGTLDRPFDDEHLEARIWGFVSAVLSTRQQGLSILLLRGETLWQGGLNGRDKGSKKSLISVALDSLSEIDKISSTKSLAMLEAVALAQNFWSLAMDDLGKHPKFLPAITRFVEAQTIEFLPADSKEILTEKAIRVAVAAHIAQLLAIHLHSRRPSSRDGTFFRQLIPKLKYYFDQAATISGYRASLHVNLRKNFEEKWPGLTLLKLRKTTLQWRNYGIDYFYDVNLAGKVLSFDPSWDSRADGYANEVEQANLNLSLVDSQVVLLRAWKLLSMELCDFVSTNRELEQPLVDVVEKCLQANIETGLPPPIFKTIVCERAEFAFVILRRLQQSMQGANGQFDRILELAWKAIYTSATEFRQALATADVGYYRSLLRIIYLVLHANASKPNQTTESAYMVLDILNLVVAKGFKELASATHTHSEIANPEDIALVTAILQASLKLPGISIIHDSLATHIAENGTIRAATTLYSWSERLATENRTTTTAYVANANANDPIYGELSLLFLLELSTIPSANPASSPRLHAIWTRALLPLSLNLLVHIGSRIAREVYAFLSFFAPQLRATITAWKARTVVTLAAVNEAVSIAMVLAVLGRMMGLAGGGASLDGFDKAALVEEVEYLLSHRNYLKSLVAATNKDEEEMLRREEEADGNGNGDGNGGGGGGIVEGGLVAKVTTGLGVLQGLLAEDEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPI1</accession>
    <name>A0A2T6ZPI1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPI1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14293" checksum="D765CB43866A00A6" modified="2018-07-18" version="1">MSPKSDLIKSRITLYKHRKLIVEARIDQKVDEHERMLSQVDYSKEYEAVFDEQLTRTLKPMWDELLALGENIEELEAESKELEALEALEVSEASEGKETSEASKGKETSEASEGKETSKALEGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPJ1</accession>
    <name>A0A2T6ZPJ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1108898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPJ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPJ1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="518" mass="58450" checksum="53143C81C0D462B8" modified="2018-07-18" version="1">MEFVKENLRLLQAVSSILFVLIIYYSSKKKSNAPLVGVEPGILGYLKAPYRWKQDPMSLLKEGAEKYGKYGKAFRITTPSRDMIVFSNQEVLEELKNLPASVATFRPAGDTMIRSEYNFHEGMVQDAYHVDLMRKNMTQKLSSLLPDVVSEVTDAFEELTDVKNEWTNVNILDISVGVISRVTSRIFVGLPTCRNQEYLNHMIQFSLNVMKSATVIDVLPWFLRWIVASFFLKKKDSQDIMVKHIGGLFETRQRTKTPHTSSTTTTSDAIQWILDAAPPGTPTLKLVQRLMLFNFASVHTSSITLAHALYDLAANPEFQDPLCIEIEEALRTEGGWTKQALTKMKKLDSILRESSRMNGVNIITVVRKIITSHTFIDGTYVPKGVWVCAPAATLHLSPELYENPEIFDGFRFYRMRQLEGNAHNYQMASPSLDYLPFGIGNFSCPGRFFATNELKIAVAYILCNYQLRLNGGVCGKKPPNVFSGIVCMPNPTEGIELKERQDREKSVLFPGHVTSCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ36</accession>
    <name>A0A2T6ZQ36_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1065730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ36"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ36"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="4">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="669" mass="72812" checksum="D7BACF58AD70D976" modified="2018-07-18" version="1">MAPTKPTPPSAKSNLSRRSDANRRVEGMGAREMDQYLSKLKKENFDLKLTLYHMREKSAKTENELAETHAELAGALSRNAELTELKDRLHAELDQAVGDAVRMITTYEDQVAELQRRLNVGNDIQQNNVQREEVRTEAGRRQDGSESSTVLNLEEDESFNDERDCGGKKSGIPNCLTVGISPFTHQPSPRLATPFRPRAYGSEGRPVSPSPSVNSNLIDLNTPLSGSQDASSFLRSAFACIDTHTTLRSRTVSSNMSFINRCSSVMSDNPGGLQTGQSPDDDFVLDSPRLSELSDSSFASMYGERDDDPSEGSGDERGMLSDNCDNPLFGEMPSRIDMAHRSETPNRRISPRREIIGFKARGRENESSVFARNLLPPTPESISPRKCNGFKLVDNEVPASRLPQSPVSSSEGKSIMTSKCSTYGTDVSDGSSTTSGINTPSTPPPGDYEEQEEATKTDCGNQKSSPYKGPSFADIANMQKRLGFRDRLDRGEGVRKSTGKFESLTLPRHVNSRIGSVRGGACGGRQSASLKAAPPPVKTNATFTSLPSTNIHTPPWTPRTPDSETTRCNSRIPPVIKRNDSWESIGSSLEKHDVKGKGSRGNGIPRRNTIALASNVAALPKKKVDTPNLTLTVDKRKSSIPALVRSNTTGTRDTKGAASKPAKGKRNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ78</accession>
    <name>A0A2T6ZQ78_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_986302</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ78"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ78"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU77635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="346" mass="38721" checksum="7A85B889F2B6E811" modified="2018-07-18" version="1">MDILKVVDIQKPSIDRPFGVGLWPIFNALFGKVMGYPADDFRFVREATPISTFKESASLIIAYYAIIFGGKAIMSNFGAMKLRTLFQLHNLFLTTVSGILLALFIEQLTPTLYNHGLFYGICNGDGGWTQPMVVLYYLNYLTKYFELLDTVFLVAKKKPLTFLHCYHHGATALLCYTQLIGSTAVSWVPITLNLFVHVVMYWYYFQSARGVQVWWKQWITRLQIIQFVIDLGFVYFASYTYFTSTYWPHITNMGKCAGEEFAAFAGCGILSSYLVLFISFYFTTYRKGGKRTAKKAVTNGNVTVGPKLTQDILGGAVNGNGHGYTNGNATNGSANGVNGSVRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQY9</accession>
    <name>A0A2T6ZQY9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_985129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQY9"/>
    <dbReference type="OrthoDB" id="5298610at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="642" mass="72976" checksum="E923DCEEDB35F57C" modified="2018-07-18" version="1">MESQRVYSPIETALLCHEPIASSILNYLAVHEVVVLASTCHPLRSFLFSHSGYWRETDLCPCPPELALNPRVMRWDGPTERLDHWRHKLLSVYRAPYNRPEDYELLTIFLRTLFVQNLVPTIQITKLVFDGLPIKRDIFFEITDRLWSCLRELSVRGCTDLEMPDFIKLLDFPEPAQQSHFPPNLKKLSCFGTVVYNEPYELRAMSLSQHTRKSLQLSLSHFRSLLIARSLECDIGPCLECEEKKLGLRGGDVCANCGEADNVVRCSACEGKENGRRRCASCRRGFCPQCRDKIMEPPLPGEDACCKDCFDQVSSFPGCVKCSRTMPPSTNYPLGKDYGITGSIQDVCGLCQKWMCTACIASEYSNEEGDSKRWTIRQCTNCFNCICKECGEKYSEEDYEKVLNLPAVKEAISLRTIYQEVTEALTVTPTPDATVSIAGGKNYTISSESARVMVRDRFRQVGPQAIYNLVAQRAETWKPLLPPCEDCEQWWCWECRLRCTCPEVETDIKLPNGNAESSNSADKTPETVNWSEMDSESVDEMDEDSDEESIELRQYQCLVHNRALDNIHPASPNDFCWSCGLWPREYTDAHADRDRGGTRHNTSASPVTEGDANTGEDEDMNSSDDWEWYSHRSHASVASWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR48</accession>
    <name>A0A2T6ZR48_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-hydroxybutyryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1026187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR48"/>
    <dbReference type="OrthoDB" id="3554464at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="431" mass="49194" checksum="425B7D74ED832D05" modified="2018-07-18" version="1">MYYRDEWPKMPEGNDFDGKHLLSLVRSGNSPFEGLWDVNLLIREIEENLDTQVIEIPDISNGSNNYGLHLKLSNHPDIVARLSRGDVNKPNFDGPTIHWHVTEVKFEVAIYQLLRSELNILASRLLYHRIPVQHVGTRVDLPKDIAGRHLFLFERTEGEKNVWWELSPEQKACLLAQTARIRASLFNFNLSLDFAATWLRERLFEQKPKILPIPVAPTREFCVALFISKIEATIKNIGDMIGWESDNVTVGPIAAAAKQSLLRLIPHIIPADNDQTSLYRLVLDHGDFGIHNMSIMVDTNGQPLVTSLYDWETGCIVPAILSDPMMAVDVDLVTDENAAPSLMGVPDYSTLDDRAEYMTWATQYFMVLFNQAPNYKRAIEPGKDARHLWFALREWRDQDPEGYFGDLGAWAERRMKELGVDSSMSRVVYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS99</accession>
    <name>A0A2T6ZS99_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000122">
        <property type="protein sequence ID" value="PUU78347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS99"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS99"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="383" mass="43184" checksum="7F53C67B9CF5602B" modified="2018-07-18" version="1">MEAELTSGNLEKYTLFSERLGALVAQLHSTRGEHAVETSRMAGELKGAEYCVAELLQSDSSTISSVEGQLATKKAFLVELQAALGATRVRGCKEKTLNKELLEKASVLDMEASEAKKELVENTASVEKSEKEVKDLRGSMEADHKAMELIYRVEADDPKRDIKSLKDKLGAGESIAREKSDLEAEMKQLKVQVSSFEELTKPQESAIKIAIKGSKGLAATLKEQSGSTQALVEGEVALTNSQNESAVKMRVIEAELSFEFVIRTAAKGARRDGRPIIWDHEWHISKESKGIMSEIHRLCDELWENPLQEVWPDEFARPIWLQTPMLVKRLFRWNISKEPKAILSEIHRLCDELRENQLREVEPTEFAIPIWLQTPMLVKRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSA2</accession>
    <name>A0A2T6ZSA2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferric reductase NAD binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1084281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSA2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSA2"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="5">
        <location>
            <begin position="686"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="835" mass="92540" checksum="6F123C4E6F2DE562" modified="2018-07-18" version="1">MGVILVLSLFPFRKKAYEFFLFCHIICAILFLVFLYHHLKLSKTNSYDGWIWACVSMWAFDRFARLLRVVILNARAFSSNPANHHLARAKFVKGTDIIQLTVYPSAEDVGYFPGAHFFVFLTGSWRFWECHPFTAADWRPSEPTLTGMPQRSPSGARSLSESLADSLNGSLSKEIGVKSGALRGGAVVKRSGSGRSGRSGSGRSGSGVNRSGSGRSGVTRSGSGRSCRSGRSGVARSGSGRSKSSRSERERSRSERDRSRGGSRERTRLRGGEPSPNDLCGGDLGLRGGGLNIEDAEAILGLRGGDLHRQKSRNIYIVKQNGNQGNIFVVSDTGKGHPIHSDAPGVGDIERTGTPRGGLERSKSESTRKELAKAKIAKAQEVARAKDAAEKAKEAIRIYELTKARELAKAKAELEKFRKAVTPPLKDPESEKSPASPEADSEKELHGEPPLKKGKEPSKAIKEAPPKPESSKRKPKRTHSKTETKEERAAAREKRAEKRRKRLAEKDEESETEPETGTEDIDAGVLEKYVPDLRGINEDDDDVDPEKLALELALGKDGLDDDDEDDEGMSIEKELEMLKQRQREEAEIRRRAIELEEEQGDLSQILLTTRTTGSVNRPPGHGRGPPRPKLTFLIKPRKGMTATLASMIRENDEAQVRRGVTRIKELEIKCLIEGAYGINRPMHLFETAVVIAGGVGVTTILPYLADFNNRSRGAGPENRTLTRRFVFVWTAREEELVENVVVKRIPKGVLNREDVSLQLYVTKKKAEGEKKLPGVRYRRPNIPEILAAERKRLVGRMAVLSCGPSVLVDITRNAVVECLTQERKHVQYFEESYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTA2</accession>
    <name>A0A2T6ZTA2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1064811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTA2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015694127" description="LITAF domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12738" checksum="65D255C2BDCAC500" modified="2018-07-18" version="1">MSMSVALLLLLLLLLLENLSPSPPLVVPITPPPIVPTGIPLLFLLLPLPPLFYCCYCRCQSCSQWGEGLVGPTPTSASTGAPPHSCPGPGPGPSLSGRCSLCLGMWVVTIRAASSVINNARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTD1</accession>
    <name>A0A2T6ZTD1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTD1"/>
    <dbReference type="OrthoDB" id="5478287at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="333" mass="37160" checksum="1F73B668193F4A89" modified="2018-07-18" version="1">MIDRGIENEEHRPTAGDGVEGPPRIPEQVVRGSLRDCLYYPPMVGAIYWTGKPKSSVKDTDRRRPWIVIEELPGGWVRVMSSTNQGQKGWEAIAKENQQFFLPISPTASNGRPVLTVKEDFDGRFVGKSLLYLCIEVDIPASDLQGERRMGYLDPSAIGIILRERSLIHAVESPAGENMREERGPRNPSRHPGNLANSGSYPDGHLIRESSFGQNSQGHSSPPTSPRILKWLEYPLCGSNGAHSRYPARSSGTPANISRAPSQVGSLGARGNRDPDGSYINHQSRNPYQNSWSQDRPQPNRSTYHARTYGRDQYPPPQSTDRPQTYTIGRSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU54</accession>
    <name>A0A2T6ZU54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU54"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU54"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="336" mass="37311" checksum="FC60E9DC9EB75623" modified="2018-07-18" version="1">MKYVETILDEDPIPGPMNADLQAEIMNQVSETISTEFLLVSLNITAILDETTIYLRREQLTQMTNGGGLSDVYSVTLNRIKKKWRQVETRDGGINMDISIGAADKCRGARSCLVLDIVLSFRDDVRALDKRSAAYARPKKIRCERNPITHNDRRCSLGGVASWTNAESQWSSDPTISKPEFNSPIIAQSDPASIVNLPVQTEYKISERMPHSFLATHSWSPKALRQKQVCNIPQTCPQNFPQAIYKDPTSAREIIFQSASGTNGLAEHVRRRSSPRTCDEHDRRGRNGTAINSLHSLNTRRDPNRGCNSNRSANGGWNPANNSTAGQNSNSNLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU69</accession>
    <name>A0A2T6ZU69_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU69"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="12299" checksum="051B66995993F85A" modified="2018-07-18" version="1">MEYLAEGDFAKHIGAPLQEAFQNISKVFEGLKNIFVVPISPVWVKLGNFGVSKRILAQATTTFHTQVPTPLYSSPEVRGLDSNSETSEYANSDSSPQTTTPRYTQKKLEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUD4</accession>
    <name>A0A2T6ZUD4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_980650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUD4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUD4"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="235" mass="26640" checksum="9FD5BCEE69101111" modified="2018-07-18" version="1">MVKFYENSFSYDYQWPAVTLAYFLRYPNPYSKHVVSSDTLSSHLDTQTGNLHVTRLHLKRGKLPASVARFLPKIKESYILEKSIVDVKHQRLETETRNLDWEGVLSVVESQVYTPGSVSTVSELETAAAGVGRTDVTTVVRFESRLGGAARNTQSDGMAGRWFSNWTTGSVQGSIELVGMRRMMEGFGGRREGMKVVLEQLRERGFVGVIKEQRQGGWERWKKAWRGEGVERTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUM3</accession>
    <name>A0A2T6ZUM3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1125644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUM3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUM3"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="620"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="864"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="830"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="905"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="931"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1001" mass="107823" checksum="BB76037BCB584F5C" modified="2018-07-18" version="1">MRSSIACVRCRRSKVKCVNVGPNTTCRACEASNRECTYPAPVASGAPRAASGATPSRPNTGGPGANKDLAPNIGSAPSHHGHTGGDRPEAPKKAKPKKPAPSGGAAASAANYTGPKAWKEALDSPILNQALLTQVFEAFQQHHSPTLPFLHPPTFLSRLRLPNSASTNTGPNSTSPPAPDRGHSPLLMLGLLCLAARHVPTLSQHFAPALPTPAAVSDFYASALKYRLQNDEDAGHGELGATFAAPSLEKVQAITMLVVHEWGMCRGAEAYVWLGVAIRMAMALGLSWDDAPEPGYPISEPALSPGNGDRNEGSPNSKRRRLEGGKSMGAKITGKEFTDKEVRRRTFWALFMLDRSLSSGRFRPSGIQLADAARVQLPCEERGFLFGEGVRTGFLTVDGLDEKSDDRNGDSIGGRWEVGDDEGILAKVVRITEIWGRVQEWACAAGGRRSEKHPPWSPKSNFYKLQQMLDSFYSSLPEHLHFSPQTLSAHMSSRTSSAYAVMHITHFLCQVVMHREYIPFLPLRLTRPQGPLDPPLFLADDPEIDKAGLEPGVTIAMWWEDSAKEIFRCARGIMQIVNGLEEWNSSVETPAVGFAVYMVGVCGVYAWSFPWMDQKGYITGSIPDPTRKSPSHSGDDEDDDMEGVRGARGPEGSGDESKKAIELITKMRERWKMAEEWYLTLGRLRNYFKTIRDEYVRLHRPGSDTEGTTGPVSGESAEAAVARKLKQGLGGGFEEYRRFEKLFHDFSGMDESELATNARAGAGVSPDVKLGSRASFSEAGADHPTAAGIKKEVKREGDVDALLLAVEGVMPDAPGGGGGDRWMAINTPRQTQQQQQTQVAPQPQVSAQGQADSGFLASLATCAAGQEPMPPNNASPGPAAAHVKSQAPSTMTPPPVNAIPGLGQGQTQAPSLSGNDISPSAARSTVQKQLSPPPPKPTFNQPKPSPEPVKKLTEHEQLQREIDKGDKCGGTEDVAVFVNGRGITEWPSGDNWLGGDAMWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUN7</accession>
    <name>A0A2T6ZUN7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUN7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="70" mass="8147" checksum="1723A4F79DDDBD7F" modified="2018-07-18" version="1">MKFFLFSFLSFLHICMIFWVGRLSVCCYVLPDRSMIKSLDWREGEGKPTKTPFTPSCFSFVLSFLLSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW92</accession>
    <name>A0A2T6ZW92_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1124721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW92"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW92"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="24945" checksum="41600681807454D1" modified="2018-07-18" version="1">MVYYFSSNVVDPPAFIYVGKDKVENEELIKYGFKEDIWLFHADKLSSAHIYLRLPEGSDWESIPQDLLTDCAQLTKANSIEGNKKDNVNVVYTPWSNLKKDGSMAVGQVGFKDQRKVKKILVEARTNAIINRLNKTKEERFPDLAEEKETREREIRNQETKAMLERKKEEARIAKERKEKAWQKDHAYDDVFTDDALEANSNQNRDAAFYDDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWQ2</accession>
    <name>A0A2T6ZWQ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exonuclease V a 5' deoxyribonuclease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1173821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWQ2"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="477" mass="53848" checksum="B1BE60F3B93AD35B" modified="2018-07-18" version="1">MSSDYGSDIDLDDEDILNILDGNINDNTAYDSTPSSTDFPQQGREEKRVAIDNDGFPEIISDTNPTSPRRVVFAPEFQNDSADQDNKEGFIRYPELTVRKDDEFIIQYPSLRVCADERIAGVQPEIQPADAPIPLENDIRSPFDRFRARRKTLSVTDLVSGVWCEQQFKYGLERGFKRTTAMKKGTKVHKVLEEQVHTTVQVEVATNEDQWGLKLFNICQGLLSLRRGGLTRELTVFGFLNGYFIQGIIDEISYTKPRTHVAEKAPPVVASDESSDSDSDGGVPLPIDLTGSSPLPSIPKHKLVAYVSDTKTRATQTIPRGSQLRATALQLMFYHHLLSGLCAGDVDFTKVLENFELDGSKNFSDTFLAQIASIDSDIDLEELLENNSLWGLWRIFQCKLRENISTIGNTLAVNYRSQKYGNVMETQIFDYNEAFLTEHLNRTIEWWEGKRPTVGVEIEEAWKCKPPIPLPFHSEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWR2</accession>
    <name>A0A2T6ZWR2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1080443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWR2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015618186" evidence="2">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10646" checksum="344B466A07977628" modified="2018-07-18" version="1">MVPTPRSLLILLLLQMTAIAAHPLAKRKGGRWRWSPRRRKRIDKQTRPPRPPLKLENRGSGLGRSPITAPVNILYGPAPLFQLEAALPARRCIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXW5</accession>
    <name>A0A2T6ZXW5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="3">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1021677</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXW5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXW5"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000013">
        <property type="entry name" value="Pantothenate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="entry name" value="Pantoate-beta-alanine ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299">
        <property type="entry name" value="CYTIDYLATE KINASE/PANTOATE-BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PANTOATE--BETA-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU80314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="373" mass="41277" checksum="45851BF2FF77A5DD" modified="2018-07-18" version="1">MIQLLRRFASLSALTKITSTMTTPLPGTKPPLTLYTSIASIRQWRRQQASRCNSVAMIPTMGAIHAGHISLIRSAAQTHDSLVISVFVNPAQFAPHEDLSRYPRTLTTDIKQLEALNTELSSPESSSKGRIEALFVPSVPEIYPSGIPLQQELQKGAFVTVTPLSSRLEGITRPHFFRGVATVCMKLFNIVQPDEVYFGQKDVQQTVVLKWMVGDLHIPTKIRVEDTVREEDGLAMSSRNVYLGEKRRGFAVCLYKALKAAEEAYLQEVAKGATVIPKRILTEPAEKVLREAGSDEVKTETEYFSVACPKELEELEQVDVSIGAVISGAVRMLPTQESEGPVRIIDNIILKGKAEVDTQGERVSQDLRTVVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYI1</accession>
    <name>A0A2T6ZYI1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60S ribosomal protein L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1079129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYI1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYI1"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="254" mass="27571" checksum="50C50B7360485428" modified="2018-07-18" version="1">MGRVIRNQRKGAGSIFTAHTRLRKNPAKFRTLDYSERHGYVRGVVKDIIHDPGRGAPLAKVAFRDPYRYKLRHETFIANEGMYTGQFIYAGKKASLSIGNVLPLGSMPEGTVATNVEEKTGDRGALGRTSGNYITIIGHSPDEGKTRVRLPSGAKKVVPSAARGMIGIVAGGGRTDKPLLKASRAMHKYKVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYASQGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYY2</accession>
    <name>A0A2T6ZYY2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_702284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYY2"/>
    <dbReference type="OrthoDB" id="5422587at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="378" mass="42188" checksum="CBEAC6849DEC841B" modified="2018-07-18" version="1">MTQALRSARHALNMLNSPSTQAAPQTLHRQPESFRASPYALHSAPKAPTCLLPQAFMVLTPNDPHPAICLPASPPPPSQPAFSHQNYNHYHHSSTLLTPIQINPPIQQVLLSEQAVPRGNTTIYSSRPPIAPTSSAVQHQAYQNSMRHRNSQKRPRLTTEAVSKIGKDSRLARWERVVGYVRDQRKTNSATTSDSTSHSDLALFSTSGIIKEIERKNRILDLLDVEEQASRSLWSGGSGGTNGVDEFVWSEDEDDDDFRKNTENQAVLDEHRRRLDALYPDEVAEEMIAEGAEIGVFELEDHDAEATVKDFEMDLVEDSTKPRPRSSPIGTVEKVDGMKQYLELLKTSGMPELNREGELEGGIDRLIARDIRRLSAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A003</accession>
    <name>A0A2T7A003_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A003"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="13172" checksum="7FD9E3C2681E1677" modified="2018-07-18" version="1">MAPQKRKAFTPLDSNITNGDQAQKRYHQDIPQTPSPNRLQSTCTTQSSGSYDQASACMESGFVDTTTIEPNHLPSSSNSPPPKPKGKARTDPFQLPELPKFSPFRAEYLLHTSRVRVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0M9</accession>
    <name>A0A2T7A0M9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_972130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0M9"/>
    <dbReference type="STRING" id="42251.A0A2T7A0M9"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="734"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="734"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="859"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="938"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="971" mass="108197" checksum="0D2131A568B31171" modified="2018-07-18" version="1">MRGAGKDSTSGRDLLYRYYGQLELLDLRFPVEERGVRVGFTWYDAFTHKPTSQYSLAFEKASIIFNISAVHSCHAANQNRSEELGIKTAFNSFQAAAGMFTYINENFLHAPSTDLSRDTVKTLINIMLAQAQEVFLEKVIADGKKSAMLAKLAAQAGFLYAQAVEGVQENVQKGIFERVWLLLCQVKQNFMDSLAQYLQALADSEGGKYGLAIARLHLAEDLAKEALRTSQSFPNSPPATSNLSSETGPALVQINKRHLALAQEKLVTLVKENDFIYHQTVPAEAAIPMLSKTVAARAIPVQELYQGDDINRIIGPDIFQKIVPMKVTESASLYDEEKAKLVRAETERADLANAEMVAALDYLKLPGSLKLLKNGFENEIEVDDEFRAWCDDIAHKPETLEERFVGLKRDKKRIVEILDRSSKTLDTEESVCEKMRAKYLDEWTQQPSSRLTQTLRADIRSYREAVDEAVNSDNLLFSQYRGVKGEIEEMRNAGERAEEGAVDDLWVSRAGAVNGGFSGDRGGETLLDVDEGDSGVTVLEQIERVEELLKKLNLIKRERAQVLKDLKEKVHTDDISNVLILNQKSIQNLEPQLFATELEKFRPHTNRLLTAAHKQSSLMKDLTSAYGDLLQDKRIRAEQSKYEALSRQRNAVLGKFKKTYQAFLDIWAGLEKAQQFYTEMTETSESLEKNVETFVSNRRVEGSSLLSQIEQRGGSEADSQRGKLLGMMERVSISSGDASKIQQKRPTPLSNVNTHQSQPPVPSNHGQSPPGTPRYTPHQYGSYHPAPTPPPPPPPTASTGFAGYPQYPPANSTNGFGRRDSYGQTQQGGSVPRRDSYQSANVQRRESHQTLPSSPPPTGGQQQQHQPYQPSHYSSPPNMYAGQVPGYPPQYNPSTYIPPPPPPGPPPQPGLSSRQSFGVLPQTSYQQPPHPSTPGQPPQGYHQYPVPQGQQHQQQQQQQQQDPWAGLAGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Q1</accession>
    <name>A0A2T7A0Q1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1077546</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Q1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0Q1"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="374"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU81311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="584" mass="65853" checksum="C5A7341EA5A04DED" modified="2018-07-18" version="1">MIDTNDSSKVPLLHPDPSPTTNSPTSDKTVPSSSNSRGAKNSRARHHHNRGRGGSGSSCSKRKKEDQGRTAYKRNRDSKWEPRNAEAAGVKEGVESREEGEKEERRPKKKVAVLIGYCGTGYRGMQLNPPQKSIEGDLFEAFIQAGAISKANSDDPKKSSLVRCARTDKGVHAAGNVISLKLITEDLDIVERINSHLPEQIRVWGIVRTVGSFSSYQQCDSRRYEYLVPSHCFLPPHPKSYLAKVCYEVAEGEGDLEGFLERNKECDGWWEEVNKKIYEQLGDVDKEVLDKALEYEVKSGAATERKERIDSQEETTDSKNIDIDPDVPPREDTTDGDINVGAGLWKKIGAIYRAEKKTYRISPERLQKVREGFKSYEGTHNFHNFTIQKTFKDPSSKRFIKSFEVLDPIVINNTEWLSLRVHGQSFMMHQIRKMVGMVIMVVRTGCPLERIKEACGPRVVSIPKAPSLGLLLESPVFDAYNRKAERDFQREPIDFSKYAKEIDAFRDKMIYTKLFEEEERAHVYTQFVHFIDSFKSPLFYYLTSAGLKALDEVEKGQGAGLVGLQLLPDNGSEDEDAAKSTEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1D0</accession>
    <name>A0A2T7A1D0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1113301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1D0"/>
    <dbReference type="STRING" id="42251.A0A2T7A1D0"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="307" mass="34381" checksum="122D788DFE98F4A2" modified="2018-07-18" version="1">MFYARAASRICRAPSARFFLSRSISTARPQASAFRPILAGQHPRLAARFSTSFTRFEKLGQVDEELALKLQTEIDLEMTKEDELEYPLSVKEYLETGQFQIIDKPGQEDVQLIRKFGDETIRVEFSISDLTAFSNEGIDDSSFYDETPAEDDSKASPSSSKGARSKAAQDEGSTSAASDADGDEYDDEPDPSFPARVNVTITKPNSGALQIEAIAQDGMIVIDNVFYHKSAELANAQTAEADWERRGIYAGPPFGNLDEDLQVLLERYLDERGINTALALFVPDYIDYKEQREYIQWLENVHNFVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1F0</accession>
    <name>A0A2T7A1F0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1076819</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1F0"/>
    <dbReference type="STRING" id="42251.A0A2T7A1F0"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="15">
        <location>
            <begin position="35"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU81570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="373" mass="39985" checksum="7559BCFAD204905E" modified="2018-07-18" version="1">MPPSTRPRPKPKPSKSTTTAISTLTTPKLKPTKGSSFHKITSVVLGSQLIPAWYTSSYPLKAIASDHDSYSSFSLSASANSHPTSSERIYVCEHCFSYTPEASELLLHKPFCHLSEEPLGKLVYAHNGFSIYEVDGEEHTLFCQCLSLFAKLFLDTKSISYDVEPFLFYTLVEDVPPPPPPTNDVATGKVGAGGGGGGGGGGGGGKAQQQQQGRKRIVGFFSKEKMSWDGNILACILIFPPYQRRGLGKILISFSYALARGEEKLGGPEKPLSDLGQKGYKSYWTSTLAAAILNRKLKKPVTVTDLSQETWIHQEDVVATLKSMGAIGRGAPNTAGEPGGWVISRGRVKEFVAAAGIKVGSGGIAMEGVILDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1U4</accession>
    <name>A0A2T7A1U4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1042451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1U4"/>
    <dbReference type="STRING" id="42251.A0A2T7A1U4"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015375583" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="121"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="403" mass="44480" checksum="C82DA96C1ADF5CD9" modified="2018-07-18" version="1">MAPLFHLLFPILLPLFPTLTTAWTDLSDETLARLPNPSDTDFDITTGALLSPILIPRVPGTEGSLKVLNHFQNFFATKLPYWKTSTQNSTATTPTSNGAEIPFVNFYATRDPPWAGEGNVGRLVLVAHYDSKSTPEGFIGATDSAVPCAVLMHAAQAVDEALTRKWENMRVKGLAGDGLGDGDGHEDAYRGVMILFLDGEEAFHSWTNEDSLYGARSLANTWESTPHTALSQRKNHLSSIDLFLLLDLLGSKSPTIPSYFPTTHWAYTHMATLESRLRQLNHFLSHKTSPNPWFFEPATKEEKHSMMIQDDHIPFLARGVEVLHVIPAPFPRVWHVMEDDGEHLDMPTVKDWARLTAAFLAGWLGLEGFVEASLPVANGGAEEAEDVTSGAVRGRGLRLKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A205</accession>
    <name>A0A2T7A205_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_970912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000040">
        <property type="protein sequence ID" value="PUU81764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A205"/>
    <dbReference type="STRING" id="42251.A0A2T7A205"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="13884" checksum="BF01CC26C5B8611F" modified="2018-07-18" version="1" fragment="single">HKGVVKLLLERVDVNPDSPNSSGRTPLSYAVQWGQQDLVKLFLRHGGVNLDSSDSSGRTPLSYSLHLDASKWRSETSGVSTEIARGIVESFGPDWTASSIVQGSETPRRPSFVQTVGPIVRQCFSSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2P9</accession>
    <name>A0A2T7A2P9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1062245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU82016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2P9"/>
    <dbReference type="STRING" id="42251.A0A2T7A2P9"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="17779" checksum="BAB8859198458AD0" modified="2018-07-18" version="1">MADNDEQHNHTFEEASAGASTTFPMQCSALRKNGHVVIKGRPCKIVEMSTSKTGKHGHAKVHLVAIDIFTTKKLEELCPSTHNMDVPNVSRTEYQFSYIDDDYLHLIKQDGSEKNDVKVPDGEIGDRIREAEDQGKDILITIISAMGEEAAISLKDAPKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A363</accession>
    <name>A0A2T7A363_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_474388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A363"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15952" checksum="6F3942648224F84A" modified="2018-07-18" version="1">MFSFSSLQFARYYLGKGGAASPSNNFRLLRYVIFNQPIFMYHFFSFLSNIHILPPLPLHDNFAAKDTDASLSPFPPFFLYFTCLACYHFTISLSHTLHLLFCCICSLPIIFSFILLDSFLDTAAALSVFCSCSDFTLFSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A392</accession>
    <name>A0A2T7A392_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_476755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A392"/>
    <dbReference type="STRING" id="42251.A0A2T7A392"/>
    <dbReference type="OrthoDB" id="5420615at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="46413" checksum="A248859A3CD280B5" modified="2018-07-18" version="1">MRKEIRAEIEREYAEKRESEKALKLQAEEAAKKEALLRLASEEIERKRIHKEVEIELERRRLEQVRIEEEAKRIGIERARMREQAEIEHERKKKEDELKVLEAFNQMELDKEVERRMKKEDERAKKEQEEKILQEAEERRKVEARNKLREKIKRDLMEEEAQKIETARIASHAAKLRELEVQRLKNAQEKSDMEGERDMLRLRIRRELEAEERARLSFETIEKLSLDQERLRLLEKALAEHALKDVIRQEEYLKMKEEMELRAQAQLSQERALEKAKVRQQLIEEAAAAQFEKEAHKVIDNGGKPGWKEETHKSPSLLANPPLQAPPSVISPGPGLGHFSDSPLRGTPPKMFANNPHISPASVPPPPPPHVDKLNLRWETNYKDDHYGGEQWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3A5</accession>
    <name>A0A2T7A3A5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1018229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3A5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3A5"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="5">
        <location>
            <begin position="188"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="583" mass="64788" checksum="17437758FE3C5A47" modified="2018-07-18" version="1">MTSLAAGLSKVLPAPKYSAEEDVTASRKPTARVLGGGDPDQQGLILKKIGPPPYGRRSAWRPRSADDFGDGGAFPEVPMAQYPLDMGRKGSGTSKALSLQVDNEGKVKYDAIARQGHNDKRIVHASFKDLIPLRQRADVGEISLKRPSEEDVAATTEKTRQALAKLVSGAVAAQKPKNVKGTNRKEAQYVRYTPSNQLGDTTKRGDKIIKIVERQQDPMEPPKFKHKKIPRGPPSPPPPVMHSPPRKLTAADQEAWTIPPPVSNWKNPKGYTVPLDKRLAADGRGLQDVTINDKFAQFAEALFTADRHAREEIKQRGLMQQKLAEKEKSQKEEHLRMLAQKAREAAHADPRGRSRGRSRSRSSDGSRDDRSRSRSRSSSEDSRSDDEAVREREKMRRERRQEEERQQRMKNMGSERKMQMLAREQGRDIGEKIALGLAKPTQSQETMWDSRLFNQSSAFGAGSGFNEDQPYDKPLFAAQEAANSIYRPKVSVDDDDEDTARSEMDRIKRSSRFEVLGKAQQGFRGAADAEARDGPVQFEKDTADPFGVEAFVKAAGEKAGAKHGLQERDSSPGGSKRPRASYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3X2</accession>
    <name>A0A2T7A3X2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1074902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3X2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="22146" checksum="714DA9C8F824D402" modified="2018-07-18" version="1">MQPCGLYRYRYAVRRIVLACLLTQEEQETKKQDDAEKTKRQRRRYYVERRRKKLYPKKQKEKEKKHLFRDFPFAPPPPTLPRIQVQDLPKNPWEMKKLLIPLLSAADPQKRKALLLPTLGELPISGSHRRRTYAGVGGTGPCTPPHGPTSNLLPDWIPVHTTQMLDKVVLSFGSAFAYSFAALKIPGKWISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A441</accession>
    <name>A0A2T7A441_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1074966</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A441"/>
    <dbReference type="STRING" id="42251.A0A2T7A441"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="687"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU82470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118037" checksum="2E4B3CAE45A82CD8" modified="2018-07-18" version="1">MAQPNGVKAPVENISPAFPHSTPADISSVKGTLYTTAQTLVQQVAFTLSDKLFTYSPDTFSLDAAAKLWSDNGQTNVRGVVPTVNAMETRLGAANVLLGYVFSPDADPVKKAVAKSIIASSPTLIQMRSALDQLSALYRVSSPFVAHVSAVDYEVSSAKLVTDYVSAVTVAQETGVGLLASFSAHEAQHMALFATLAATVLPMVHIYDGVSVSRESAKIKDVLDQASLQNAFSSVLEEQKEAPKKADQGAKVNAILRSLNAELGTAYSLFEYEGHDEPDAVLVTFGSVESLLATQIAASLIESGEKIGVIAVRVYRPFSESHFLEALPKTVKRVAVLGQVANKTAAEDSAVQSALYVDVVAAITMSDIWTLPPPIVDVKYAREQVWSPKEFAWIFDQIIRSHNVVVEVPEEELTPEASTIDAFSLLEENRYAQQYVFWDGDDAASVLAAPIISKLLSEDPSRNVSFQAAYDNAPLSGILHSEIRASSRAIDAPFHIEHADISVVNDIQLLSKFDIARRTKDSGIILLKSTIKDDEFEKKLPAPFRRAVTKKAINLIIVDPSALGEEAPAAVESALVQLAFTRLVNISAPLEKLSQLNHDSPAVHQASEKLDNSLRKVEIPKEWADAQEDNEPSHLPTIPQATSFAINDEKHITEPGSTIKTSQSAAQAIAFKEAYGAQSALRPDLSMKNYIVKVQENKRLTPEYYGRNIFHIEFDLTGTGMEYQIGEALGIHSQNDPEEVSEFIKFYGLNADDVIEVPSKDDPDVLEMRTVFQALSQNVDTFGRPPKKFYESLAAFATDEGEKKALLTLSSAEGAAEFKRRAEVDTVTFADILLEYKSAHPSFYDLVRIVSPLKRREYSIASSQKVNPNSVHLLIVVVNWVDPKGRERFGQSTRYLSRLPIGAEVTVSVKPSVMKLPPLATQPLIMAGLGTGLAPFRAFVQYRAWQKSQGVDIGSVLLYMGSRHQREEYLYGEEWEAYQAAGIVTLLGRAFSRDQPEKIYIQDRMRQSLDDIIEAYIKESGAFYLCGPTWPVPDVTEVLQEAIVEEGKRRGVKMDGAKKIEELKEGLRYVLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4D7</accession>
    <name>A0A2T7A4D7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4D7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="26856" checksum="404F05D5F50AB6DD" modified="2018-07-18" version="1">MSTSESAVSPSSQFLVSESTIPAASSTHIPDIPGRTWEATTSLSPVSSQDHTQTMDFVEYVEWHEGMGGGRNRSPNTPPLIRLSPIPSQNQNDFYSDSDSDSASTYQESVSTTLAVSFQAQTIEPLDSDLSDSHANTPENHPTLPNQDQQSLVINNLLFHEAKTVVRTLWGYTNWSLRKIQRELNIPLSTVHRIGHQERTSSKNFPYPGRGRPCAINVAVKQLLMETATVNGHNRRLALSQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4J0</accession>
    <name>A0A2T7A4J0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4J0"/>
    <dbReference type="STRING" id="42251.A0A2T7A4J0"/>
    <dbReference type="OrthoDB" id="5415394at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="27435" checksum="7A26DFC198E1E5A9" modified="2018-07-18" version="1">MNLSSSSSRNNADKQPENSEEGSQSSPNASVTLYPLYEQAEATKAKIESTVARLPRLAAQADEYLAQEMANVTDAYFDGIASEDTADAQKQIEEAIARLDAFYNDLGNRTQANNGSRNRAFTEPGPRPPWIFPASDISGQTGESSARGGRRQQLRSLGVLPGEPENDPAEHGLMHPGERVINMPPPPARRVTFGDSTIIGDSPTGPGFRRSFTFRSVVSALKRNPGESKREKVKDLWRNVRDRLKKNHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4P9</accession>
    <name>A0A2T7A4P9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_966784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4P9"/>
    <dbReference type="OrthoDB" id="5373826at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="16419" checksum="72B3183266168FD5" modified="2018-07-18" version="1" fragment="single">PAVYTPVIRPTHISMSYADSTCSSNSDVSPFFYEGIWLEGPDAPQDAPTEQTPLLSAPVTFDPELDGFSVNMTEPVPLKSGDLELGSLVQTGEVVGIGTRISSIICRLWNWILRVFQSCGLVADPGAVDENENESEEDEGYCGGVGESVVGGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A531</accession>
    <name>A0A2T7A531_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">von Willebrand factor type A domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1040324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A531"/>
    <dbReference type="STRING" id="42251.A0A2T7A531"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="3">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="295"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="772"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="925" mass="99320" checksum="99153A5432190554" modified="2018-07-18" version="1">MTTRVSYADNGCLQSLPLVSTTLKSHIVDLTVSHTLTQVYNNSSARDISEAHYTFPLYESSSVTDFQALIGEKIIRGVVKARAEAKAIYEAAKSAGKVTALFSQDTSEVFTTSVGNIPAGGSVVVVIKYVHELKQDIEVDGVKLVIPAIIAPKYGTAPVTPGLDFGDRWRTCWDTFSRNIQDIGNAQNAGISLSITATMSGPIRGVTSPSHPISIGLGSHSSSDDADFNPMKAHATLALASTSLTSLDRDFSLLISTNNIGDPRAFLALHPTLKDTSTLMVTMVPRFALPSQGHEIIFVVDRSGSMGDKIGTVRDALQLFLASLPVGLHFNICSFGSKHSFLWPQSQEYSEASLNVAKAHVRGMDSNMGGTEILAAIIDTMRARRSGMRTEILILTDGEVWNSESMFRFIGESSEDGNVRFFSLGVGNTVSHSLVEGISRAGRGYSQIVNTAGNLQKKVMRMLKAAMTPHVNDWDIDWAGKPEKRFATLAAPAPRTVAPISLFDPNCDPDNTPFALPSSALTLTLPKVIQAPTVVPALFSYSRTTVYFLISNGDRPEKVFLKGSTHVASSNTICPLQIEIPVQAITSTGASLGLYQLAGRKLLQDLEEGRLSYLEGIYDKVKEPIKHTELISKEGTRVGVEFGLASKWTSFVAVAEDKSTGKGGANQQLGERTDVSAEGETQTTNSRSASSSSRGAAKEDQPAGRERANQHDRTAKRVSTSPRLQAQDYIYQQKQAQQAQMPQQQQQLPGGGNKGSGAPSKESGNGKIARASVSSPSRSQNFSSPTFSSSSGFSPSSSHGSPPTSQAFAPTSPRNATRRYSASSPSWSHNPVSDLATLPQSNGMFKADGRIFDLLGLRNCGLENVHADGDFVATVAVIVALEKKFPELSEEWEFMVSKAKEAVQKLYSEGDREAVVSAVRAALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A597</accession>
    <name>A0A2T7A597_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-xylanase</fullName>
            <ecNumber evidence="12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1061453</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A597"/>
    <dbReference type="STRING" id="42251.A0A2T7A597"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="26"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="347" mass="38035" checksum="41F20129437BADFD" modified="2018-07-18" version="1">MHYSECIPGTVTTVKAGAPTHTARAAAAYPGLNTLAKAKGKVYFGSGTDNPELTDAQYLALLSNTREFGQITPGNSMKWDATEGSRDAFNFTRGETIVALAEKNGQQVRGHTLVWHNQLPNWVSNGGFDNATLISILENHITKVVANWKGRILHWDVLNEIFNENGTWRPSVFYNTIGEAFLGIALRAARAADPYAKLYINDYNIDGTGAKSTAMYKLVEKLLAEGVPVDGIGVQAHLIVGNVSSTLQTNWERFTSLGVDVAITELDIRMTLPVDEAKLAQQAEDYKKVVTACVNVPRCVGITVWDYTDKYSWIPRFFPGQGAALPWDKDFTVKPAYEAIAAALAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5L6</accession>
    <name>A0A2T7A5L6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5L6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015742563" evidence="1">
        <location>
            <begin position="26"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8862" checksum="C031E18B8E7A8DEA" modified="2018-07-18" version="1">MIPAAPTNFDWSISVIIFLHVPCSATLIPMDDLKRRVPVPFLDIRISILRRKIFEIVSTRDDDRSFKMEAGGGRYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5T9</accession>
    <name>A0A2T7A5T9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5T9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7203" checksum="B4535E2E06D9CFB3" modified="2018-07-18" version="1">MRTGSSSHKILIPAFGYFHAFTYAPIREIFIISFLSCLCLLQPSVLGESDEKRPAMAIGFETRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A615</accession>
    <name>A0A2T7A615_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1119781</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A615"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="18">
        <location>
            <begin position="242"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="160"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1529"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1557"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1631"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1688"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1720"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1731"/>
            <end position="1745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU83158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1751" mass="193357" checksum="559AA2EA316EDA02" modified="2018-07-18" version="1">MTLIFEHSSAPLRTIKEIQFGLLSPEEIKGMSVCHIEYPETMDEAKLRPREKGLNDPHLGSIDRSFKCATCDEGMSVCPGHFGHIELAKPVYHVGFINKVKKVLETVCFNCAKIKLDETNSQFADCCRIREPKARFNAIWRLCKAKTSCDADTAIDGEGGFDEAPSEKKPKSHGGCGNKQPTIRREGLRLIGTWKPDKDQGDESQQPEKRHITPAEVLNIFKHISNEEIRKMGLSEDYARPEWMIITVLPVPPPPVRPSICVDGMGGGMRGEDDLTYKLAEIIRANASVRDAEQNGSPAHVVNEFEALLQFHVATYMDNDIAGQPQALQKSGRPVKSIRARLKGKEGRLRGNLMGKRVDFSARTVITGDPNLSLDEVGVPRSIARTLTYPEIVTPYNIHKLHELVKNGPNEHPGAKYVIRDNGERIDLRHHKRAGDITLQYGWRVERHIVDGDFIIFNRQPSLHKESMMGHRVRVMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAEVSQLCMVPLNVVSPQKNGPLMGIVQDTLCGIYKMCRRDVFLNREQVMNVLMWVPNWDGTVPTPAILKPRPRWTGKQMISLVIPPGINKVDLAGGKWSPLNDEGLLVHGGELMFGLLNKKAVGQSHLSLIHIIYNEKGAYRCLEFFNGCQTVVNYWLLHNGFSIGIGDTIPDKLTIEKIAATVKEKKDEVNAVTDKAQRNELEPLPGMNIRDTFENLVQKSLNSARDKAGSDTEKSLKDSNNAIQMARSGSKGSNINISQMTAVVGQQSVEGKRIPFGFKYRTLPHFTKDDYSPESRGFVENSYLRGLTPQEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDVMAKYDGTVRNSLGDIIQFIYGEDGLDGMFIEPQTVDIIACSDAEFEDKVRVDVMDPTRSIPLEFLEVAQDIAGDVEVQAALDEEFEQLQRDRAFLRSLQKDSVDEKLQLPINILRILENARTIFRIKHRARSNLHPLEVTEKVKELVKKLVVVRGNDPHSIEAQHNATGLFMCHLRSRLAFRRLVIECNLTKVAFDWVLGEIESRFARAAVQPGEMVGVLAAQSIGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEILNVAKNIKTPSMMVYQVPENTHEKETAKALRSAVEHTTLRSVTETTEIWYDPDPRDTVIEEDKETVSSHFLIDTDSEDIDRQSKWLLRIIFDRKKLLDKDLTVERVGMKLMEEYGNDMAIIMSDDNAEIPNIRCRMKNADQAKSLDEESDLEEDTMLKRLENHILDELTLNGVKGIQRAFLNDKERTRIDETGKFVMSKEDPKCKEWVLDTTGTALKQVLEVEGVDTSRTYSNTFEEILQVFGIEATRGALLRELRQVLAFDGSYVNERHLALLCDVMTSRGHLMAITRHGINRADTGALMRCSFEETVEILLEAAASGELDDCRGISENVMLGQLAPLGTGEFEVFLDEKMLAEVIVDNSRITGGEIPGMGKGVLSDGAATPYDSSSPMYGDPYVGSPDAGAMFSPMQHTGSETPGGLTDYQAPGFGPGYAAGSRSPLTYSPTSPFGTSPTSPGYSPASPAYSPTSPNMAITSPGFSAASPRFSPASPAYSPTSPGYSPTSPAYGGGLGVGGSPTSPNYSPTSPSFSPTSPTYSPTSPNYSPTSPAYSPTSPDYSPTSPAFGGGVGNSHSPTSPTSPNYSPTSPVYSPGSPAASYSPTSPTFQSPTQGSPRWSPTSPGPSYSPSSPRDPPRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6B0</accession>
    <name>A0A2T7A6B0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_965195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6B0"/>
    <dbReference type="OrthoDB" id="5377009at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="361"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="591" mass="63481" checksum="8CEDD122869631D3" modified="2018-07-18" version="1">MATRHLPIRDLHHTNATMLPNNPMLASPPDDMPATATTASVAPTSISPSVDSPPPTIQVTPKKPTARISSASLAPAVSFTRPPATDPPVSSPLAPHQGNSWDLETSHPGNGARFTSIPITPPRVSAQSNTRRLPPGSVSQNSLTPGRESSPSRLSTISALAGSQLSRVASARHIRSHSTPMGLTGDNRGKHQQQQQQRNTSGLFSSIFTPSTRQSSPERQDPPPSSLRAVTSSASALATVMGTPKSGNKGFFNFAFGGSNQPNSPPSSRSSARALSPDRDTCLVDEFAGISFRALMQSYTIEPLGTPETPEEALKRTPEGRLGELSETAGDLLERVYEAYKARTNALSEVMDRQAEDQDLLEESRTKTAEYKSQLERLATEERAAREEQQLRLAAYEKRIRDLEDELYREKAKVQDFEQRAVMANQKKRTSAASDSGFESDADSLFSIRERDRMTSPVGSFLDTGIDETSSATSTSTITNSTASAAPLKCDSCAKSLHPVSSSASSIASMRNPTPLSQAWSPSNNTNNGGNNPTSKWGFAAALRGNRQTGVWGGSDAEIVRQENRMLRARVGELEAVVDDVLEVVAGRGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6F0</accession>
    <name>A0A2T7A6F0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1098705</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6F0"/>
    <dbReference type="STRING" id="42251.A0A2T7A6F0"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015643613" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU83319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="508" mass="56970" checksum="1265BA1EC1E677E2" modified="2018-07-18" version="1">MWRRVYLLLLAVRVYFALSPSYIHPDEHFQGPEVIAGDIFDWRITKTWEFTSSAPIRSAFPLWVVYGIPMHLLRWIAPGSEPPSPWLVFNTLRVLFFLISFVLEDWALQELIASPRLRRTSLLLLASSFVTWTYQTHTFSNAVETIGVAWALVLIQRIKTSKEAAWLSSGLFGMTVVFCFFNRITFPAFILLPASQLFPHFLRHPTCIIPLTFTTLLTAGAAVYYDTVFYSVNIPTISLTSLASLFETAPVITPINNLLYNASPANLSHHGLHPRWTHFLVNLPQLLGPAIFCLVTIRQASLPVLSAISGISLLSIFPHQEARFLIPAVPLLLCSISLPRNKILNKLWITSWIIFNVLLGTLFGVFHQGGVVPAQVYLGSLPPTPTPTTAVWWKTYSPPTWLLGAKDDSLITVDLMGSSLDKLIETVKPLADCSQENYLIAPMSATALDQFASVNSPSQPFTLEKKWEYMNHLNLDDMDFVSDGVLFTVQRVVGRRGLAVWRIGKIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6I5</accession>
    <name>A0A2T7A6I5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000014">
        <property type="protein sequence ID" value="PUU83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6I5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="227" mass="25288" checksum="39B9817EC05A97C3" modified="2018-07-18" version="1">MSPRPFISYTLVDFSLKTLSTASNVHPLAGLLQFHHPKKLQPERTTFNQKQSDSGLQIMSSYRNEGMSEHSMPSDISSFSKGKRTTPQASISFSDPLRALPPPPPPIQVHVRLPVPSPVACLLLKEKHPAGWSTKYRNHTQSNYNPNPNNAHKVNQADRVGMIDLVEDNNAEEGRKSRAAEFGSHARNTGITEERFVAQKVAIWEWMWVAKQTGDNIGVGTPYPVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6X3</accession>
    <name>A0A2T7A6X3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6X3"/>
    <dbReference type="OrthoDB" id="5348653at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="220" mass="24528" checksum="B61E1577A47FF453" modified="2018-07-18" version="1">MSYNHGGYDNEDGFNGRDRPQKEILFRPETMREILSNAAQTGSHDLGPELMASINSHSNPNPQRSSSYSQGNRQSPPRSSASRQNSGLTHTPPRDSNYGSSIETYRDGNGDLVQASKNGEDLPLRVQTNDPEWNSLSRGPPSRTNTGHSTYRNAEGDYVSEHRGGNLPVTTHGYHHSPPPSEGRRSPPIYETRDREGNRVQQYDGDSENLAVRAHHVWHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Z3</accession>
    <name>A0A2T7A6Z3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1072502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Z3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10677" checksum="8E642BA1148627EA" modified="2018-07-18" version="1">MITLRPAFISPVPFSFIVHFSPLLTNALVHPLPFLIPSCCHGYLWRGGYAGVDMFLDSKGLPYCMSVATFSMLPFDFFSKLTFCRSPREENILGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7P1</accession>
    <name>A0A2T7A7P1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioesterase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1071984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7P1"/>
    <dbReference type="STRING" id="42251.A0A2T7A7P1"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="3"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="115"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="29550" checksum="661B6933E382FD77" modified="2018-07-18" version="1">MKIHSMHCYFILAGNAAVPIVYHVENVRSGRSYATRSVHAKQKGQTIFTTTCSFTRPVSEDTDEPRRTVQHSIKFPKEVPAPEDCLTGAQMINKWLSEGRVGAEVAEFLKQGEANDPFEFRRAGIVNDTPETDPTHKLQRQWVRARGNILDEGTHLPALAYFSDSSFIGTASRVNPQARSGQVGMKVSLDHTIYFHNARNTRVDRWLLVESDSPWAADERALVTQRIWDPEVGLLATCYQEGLMRLRDGREGESENHVNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7X8</accession>
    <name>A0A2T7A7X8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1071765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7X8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="59" mass="6955" checksum="290CE6C18EEF2106" modified="2018-07-18" version="1">MRVDKIDKYSSPNPSLVKSFPSVTPEIGFSPGEMRRIHRFLRQTLSVSYRKPYHYPPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Y6</accession>
    <name>A0A2T7A7Y6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1071366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Y6"/>
    <dbReference type="STRING" id="42251.A0A2T7A7Y6"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU83856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="520" mass="55465" checksum="FEC2B2DC0C758F1C" modified="2018-07-18" version="1">MVNMDSPRLDQLRKTLRPLTFAVFAGSQILDIINVTGVTFALPSIAEKYGISETEASWVLSAYSLTFGSFLLIAGRLGDVIGHHRVYSVGLLVFAICSAICAGVDNVIAIYVVRAIQGIAAACTIPTSYALVATTFTGKSQQMAVSGLGACQAAGAVIGTLVGGAFTTTSIGYKGIFWLSFALSMVFAVLAFLLVPPTPTDLPRAKKLDYPGAVFITVGALLLVFGFTEAPTDWNQAKVIAPIVLGGAIIIFFIIWEEFIMEKFFTMEPLIPKIVWSYHNFPPIVAITGLTYATFFIILLNGSQFLIRVQGKSQMTAALEFLPVSIVALISMFALGAVYGKISPKWVIAVGEILGIVGILLFSRNEVNSNFWRYTFTGEFVMIIGMAGYFVNYLNVAMSSAPNNMQGLIAGILQTVAQLGTALGFAIASSLIRGETREELKDAYRNSFYTSMAFGAASFVVAVVFIKSSMVPLKGAESQEAVVEKEGSVSNENVAGDGESAMVGTAVGSRAPSSLEKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A857</accession>
    <name>A0A2T7A857_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A857"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="18012" checksum="D5BA738D786A30F0" modified="2018-07-18" version="1">MQAGHPRAGPQRITVMKKKMSDLPPSLLPTPEEKIQYHHPRHPCERKFSLFSSALHSISHSVHSFTHSSPVRLPKKGGDRRESKPEPTNKYLCTPDIRAFARPFIHPFIHLFKCSLTYSPRFLHHTFVPLRSFIHGKYDISTVQREQKSRVEELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8R1</accession>
    <name>A0A2T7A8R1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_961610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8R1"/>
    <dbReference type="OrthoDB" id="5415204at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="581" mass="62717" checksum="3C650E0FF1F820AE" modified="2018-07-18" version="1" fragment="single">PIDGNRVEQLRARSTRYQRKSLGLRETAVPSQVIPFPYGPHRRRDGPSNIRRPPQVYIPGSSVRLGQVREARREDETRRIREIHTQVRSRSERNRRGFISRGGGSLGPLYQTSPPSTIHSASSQLCQPPNSPWSNSSNISPSPPTSSEGTQCSSQPSYLAEHSCCQPSSTSSIGAQHHFIPPDRIPESTRTSDEFTSQVSAEPVMSSEFSCYSLEELESKLETITEDESHESTRSSLWSTEPFNHEQKCPSIEMEHPGSLVNFCSSTTSSSAGSDTVHATSEQEPSSFTASHTPPQAEAEEVAAALSPQPCAVKRPQSPRPPDQSPGGHRRIHAPTPAIITITTQTFERPASSAGYSHSSTATTHASPSSPSTPSFKPPNESSVVSATPCVNPDAVAPPEAFAPTVLSPIHTKIIPSTSDQLSLPVEQEEKPGEQEEPEHKPQKSEDVRSNISSSLSFPIHHDGCSICTFVPYGASNANSVVSPRAGSSSRSTPFPAYQSISPRGAMLMRPSAVSPSSRNILSRVGEPIVDLQRELREAQLRQELERLGGIPNRVARPATSLQATVESIAGDSDDTGGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8W7</accession>
    <name>A0A2T7A8W7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1060423</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8W7"/>
    <dbReference type="STRING" id="42251.A0A2T7A8W7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015407202" description="Nephrocystin 3-like N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="57"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="640"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="680"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU84163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="869" mass="98191" checksum="8EB0EC496806BC3A" modified="2018-07-18" version="1">MFLVCSPSLPIIVLNLWLRICAATFEELIKCTGWRVSRPEIDLDHLRDEYYLPGGDSGKWIFKDAVYRGWQESKESKLLWLCGGPGTGKTMLAKRVAAEFLTGPDDPPEGVKLVFHFFPPELPSGEISTDEAEISQPRLAKVASDLLYSILQQDGHLFDGCKAELEKQGDRFFTNLSSLWKVLRKAIKDCRTDPVYILIDGVDGLKESLCKELIGRILGLMETRTVKVFLSSRDVPHISNNLPRDCRECTKINLDTNSFIKEDVEKFIEHRVNAWGWDDELKERAMEALLAKSEGIFLWASLAIDNLTYFSSGPDFDKVLKKPRLELEDIYGKMLHTVRSRGESGEILNMIWSVALALRPLTFAELGHILACIEEKEKTEQQPSHERSSSKIRRRTEKEIRIYVRSSLGFLRATAETVSIVHHTATEYLFDEYRKGALPVISKGLADLAVSWECFRYIHHAFGDPERFPRRDIRGCYSRSGNSSLGSDSQEVELGLASREGAWKDQEEAAAKREFLRYAAESWFIHARRSIEISRDSFCDDSAHNWLQHQFFETSDIIRKPWIELCGDTRMEALAGEQTPLHIAVCLGLMPLVEKMISEFTQGMNSYRSPLHLAARFISGVYKILIDKSELSLLTVSDQDGNTPLHEAAISGHSSMLNALVKTLAKHKACSNAINKKNHSGNTALHLAFQFDHTEIVKLLIKEGADTTIKNNAQLTALELGVKLERGDSLDTVKEMRGEAEEGVEGLVEGPRQEPVDEVRASLGAHPPGGLPAIQQGVQTVGYVGMLRDRFQARSLSELPPPQRSRRWEPLRSNLLNPWSPVVSRPRSPPETRPPGSSRSLRVKLPWGQELRLRRGLSRLFRRYRKAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Y7</accession>
    <name>A0A2T7A8Y7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1070414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Y7"/>
    <dbReference type="OrthoDB" id="10620046at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="9225" checksum="1C2CCC72E706D770" modified="2018-07-18" version="1">MPNDQPKVPSGKAATSSVKPDANVSLSPAAAAGISVASLIAVMILVGVCLSIWRRHLKRGANEPDFESVWDGQKFPRNVPTLGERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A951</accession>
    <name>A0A2T7A951_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_277757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A951"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="17820" checksum="88188DDC4E891C69" modified="2018-07-18" version="1">MPARHAASAIMIACAPDISSLNGPLLSSPDGYKTVPPLAPPLPPFLFISHDPQSLLSFFTTIIHSVFPPPLFFLPLPVVPPPLSASLPLPSFCFSFTTNWVEGIIDWLAVWARLRPYRTPCPSSLLIPTSPLQPCFRGSRLLSLADLTDTSISLNHLCSASTGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A990</accession>
    <name>A0A2T7A990_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_961032</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A990"/>
    <dbReference type="STRING" id="42251.A0A2T7A990"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU84294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="448" mass="47838" checksum="D8EFF15599076BC1" modified="2018-07-18" version="1">MATAAAAPTELARTSSLASRVLKAIPGSDRSAALTAVFEHLQAAKDQILEANRKDLEAAEEQAKAGKLSLSLIKRLDLWKPGKWEDMVQGILDVRDLEDPVGKITLATKLDQNLDLYRLTSPIGVLLVIFEARPEVIANITALALKSGNAVILKGGKESTHSFAAIANVISTALSTTSIPPGSVQLVLSREDVKALLDQDQYIDLVIPRGGNELVRYIKDHTKIPVMGHADGLCTIYVHADADDAKAVKVVLDAKTDYPAACNAVETLLVHQSISSTILPKIAATLLAAGVSLRCDTTSKTALEASSLPPSSKAIIQDATAADYDTEFLELTLAVKVVSSVEEAVEHINIHGSGHTDTIIAEDKEVAEKFMAGVDSAGVFWNASTRFADGFRYGFGTEVGISTNKIHARGPVGLEGLMIYKYQLRGNGQGAGEYGSGKKPFLHQKIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9H3</accession>
    <name>A0A2T7A9H3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CHD5-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="11" type="ORF">B9Z19DRAFT_960616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9H3"/>
    <dbReference type="STRING" id="42251.A0A2T7A9H3"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015593192" evidence="10">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU84387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="22851" checksum="1B8DBB5F032ECB12" modified="2018-07-18" version="1">MISLLILVVVLTIATHLVNTLGATAISNTLWMIYTSLPTKTSQEVQNQKALQKEVVKLRAELRGTSSQDEFAKWAKTRRVLDKKVVDLEKLTGSVNAARTKFDTQIGFVRWVSTSGAGWAISLWYRREPVFWIPEGWVPGYIEWGLSFPKAPIGSVSIQVWTFAITQVLRVIAPVIESLIASVMPTRRPVTPMPAGSGEKDKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9J8</accession>
    <name>A0A2T7A9J8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_7024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9J8"/>
    <dbReference type="STRING" id="42251.A0A2T7A9J8"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15138" checksum="52EBE8E94EB57FFE" modified="2018-07-18" version="1">MDLFGDNSDSEVEPLGAGLVEPAPILKPRIIETTFDGLLSSPIKLHEDLAKGCGGRIWPAGETLAKYLLRRYGGGSNELRGKRITELGAGGGLVGLAVAAGCDISESELYITDMEAMMEMMARNVALNKFEGKVKVQLLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9M1</accession>
    <name>A0A2T7A9M1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_960637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9M1"/>
    <dbReference type="STRING" id="42251.A0A2T7A9M1"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="132" mass="14937" checksum="7219F305838DEEEE" modified="2018-07-18" version="1" fragment="single">GRGVFATHKIEAGTVVDTEPVIILNKEQFDNYIQHSVLLHYSYLWNDREIHDTLGNCSRAWIHVQSLVIANRTSDGSKILGKEVIVYTALRDIPEGEELLISYRSHLTFEDVEAAQTEEGEDVTDVLARIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA06</accession>
    <name>A0A2T6ZA06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1036975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000572">
        <property type="protein sequence ID" value="PUU72330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA06"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA06"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="325" mass="35567" checksum="E12FB3400C98BF97" modified="2018-07-18" version="1" fragment="single">MDDITFITMHDLSPEARLVYASHSITEVLGYDCREIVGRSCFEYFHPDERPFAQSVHGRGVELDKAAVLSYCRLKTSDGNYVTCECVFTVVYSVIVASTSLYRPTSRSQGRAMAAPAIRRAFSSSPADPRFHMLTHLSEKFKAPPPGSHEPRAALILNRFTKTCSILYASSALNDLLGVELDNSVGISFYECIQRECLEEAIQALEHAKENDSIAYLRFIWRNPGENQGGRDPIYSEDRDEAAINGNANGRARQQLPSASDSDKFPSPLNSAPGPNVQPSALVVEAVVSCTSDGLVVVLRKARPIIPSSGPLGPPIGQFVSPWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA92</accession>
    <name>A0A2T6ZA92_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000543">
        <property type="protein sequence ID" value="PUU72417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA92"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="14810" checksum="83408B048A44D4B1" modified="2018-07-18" version="1">MFLARITPSARSLSLKIWTNDTLNSVNTSLLTGCSSFPTDGSSPLIEGSSPPTGGISLPTHGAEEIVVEKIFPILALFSYAQLICTIASKLLASGFYFSLKPVSQTIDGNLAPSNYTYASSSFSEDPVQSPVGSPRAVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAG0</accession>
    <name>A0A2T6ZAG0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1137699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000545">
        <property type="protein sequence ID" value="PUU72414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAG0"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="15700" checksum="CCD84FC3BB5343E0" modified="2018-07-18" version="1">MLGLQQIPKKLALTGKLGMKQEEVVKMSGKLFKLPVDVNLSSNVLDVPEFFWDAEPTLHTLYAAVREYLKIKQRILVLNERCRVYLDLMEILLDSFADSHMSRITWIIIILIVLLLFVTAAEVAIRFGLLSARKKVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAM5</accession>
    <name>A0A2T6ZAM5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000516">
        <property type="protein sequence ID" value="PUU72519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAM5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAM5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="12590" checksum="3562B1B7848282D5" modified="2018-07-18" version="1">MRFGSLRLASTLQTAKQRSTNTISSGGGEIAHLDPDPVFDNGASYEMQDKPRRSAPVPIVATLMEMSDPLMPDHAPPSIVTYSTTPATAPPAISPPPPRPTEFDYSRSQTQPCVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAN1</accession>
    <name>A0A2T6ZAN1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_659467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000512">
        <property type="protein sequence ID" value="PUU72533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAN1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAN1"/>
    <dbReference type="OrthoDB" id="5431134at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="658" mass="71120" checksum="E19BD34DC679003B" modified="2018-07-18" version="1">MGPERSVTPIVPPAMPDGVEVELDQVTPDTAGPQNHEAEKSRVSDTWASASGLDVSLQPAGNGGASIASSPEKDDLDRFLGELVRANTPAPRSQTTSPRPPSNRASMDDASQSLPPVPAIPEHPSPPQQFVDPVPQSHFQHPNPNRESVGLLSLYDSYWADESVPPPPIQPKNPRRPSAALEAEAAKQELEIFTQTSRSSSEHRPSSPQPVPPHPTVEPPTPDKKSGVALPPVRIPENNFHGDSSLATPASVVGTPDSELVEMMIARKHYLARTQTGLSIRSDGTGRRISDDVMLRVKGDEMMLDKPDDIVPPDVEFKGMASEIIIGSEVESAMQDERDQKDSKMEAEVAAPARVIGPDSEGMEAIGGPTRVPRSESSEGEDNAEKTPMQSDFARELVNQFSRPQTLMLKDTMPMPSGVLVMPPMPPKEEGEEVAPEVVDFSTKDDDEELVISETGTIELGKSLTRGSTPSGVHLDQRPPKDVEKMSQYLHLRDIARLTEPGDRIAAYGQATRAIAESETGLSGWVSWMMEENGGEELLKIQVEQRPGTAIQGLKKSTSRAFMGVGRSSVDDSPNQPSKQHQHQQVTPPLHNASWAPQSQGPHGGEDDPRADTTPQAPGASGGQHVSPVVDKARGFFNRLKKVYNIRPTRAFSITNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAP7</accession>
    <name>A0A2T6ZAP7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sodium/calcium exchanger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1137239</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000504">
        <property type="protein sequence ID" value="PUU72571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAP7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAP7"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="935"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="239"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="511"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="898"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="713"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU72571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118411" checksum="2C8AA8DF24C66F1E" modified="2018-07-18" version="1">MEPQTPLAAGDASRDVVPSSVESFSSAVEQIRTDSPENIARTESRLSRTSSVASSLRGRISSPDRKPRRPSATRRTSTVGQPHKGQEFSVDDETDEVEGDLGQRHRGATGSTGFAAMRRHSQLLRRRTTTQTALSNVDSTDDEPAFQQDDLPSEEQETEEEEDGEEGTVRGETYEPSVAGSVESFTLKDRQEAINVTHPFGIRIWKPALYKKNRSVQRTAEGDIHSAPGGRVGNALFFVNILWVLLFGWWLALASLIAAITCYLFFFTYSAREYGRVLLGLAGYLWYPFGRFVELKQEEAYAEEDEGEGRSISEYEQWQAGDIEEGQTFFGPHTPRTLVGRRRESLDSVSEGDSVLGTGERTGLLSGFQSQRRKRRLFGRGQWNVGRVLFFVWFYFIIAPLLLFVSCLCWLLVFTIPMAKVTALLCDHLRRHPLALSFHSDHTYSRRPGTPSTSILLCTYRAVGWKYYKYTIDGTNIFFINLMTVVFFVIADHYALGKALGRGTPLTSPATVFTLSLCSVIPLAYFIGQAVASISAQSSMGMGATINAFFSTIVEVYLYCVALKEGKGRLVEGSVVGSILAGVVFMPGLSMCSGAIKRKTQRFNAKSAGVTSTMLLFAVIGVFAPTLFYQIYGTYELACRACRPEKDPHHADCRRCFFVQTPPSLSNEFYRDAVQPYTYIAAVFLFISYVIGLLFTLRTHAAVIWQVPPVHPPAQPAPPPVAEPVRGSSSRGHDGISNQQSYGATAGTSTSGSLRDNVMFKRILGQSLDNFGLRVDGAGSSAHSQNRGSTLHVVPPRSADDFVTPPTAAGPLDTPGSHGLFTEENAEFVRSMAEIAAVTTTAAYQDFQRHGMGRKSSATPARPPVHSIPAVEEDIAAVPDAGHGGHDAPNWSRAKSSIILLGATVLYAVIAEILVNTVDVVLDNLVIDEKFLGMTLFALVPNTTEFLNAISFAMNGNIALSMEIGSAYALQVCLLQIPALVFFSAFFTSEAAPMDLVKNTFTLIFPQWDVITVILCVFLLSYMYGEGKSNYFKGSILLLSYLTVMMGFYFSSFAKNVQTGNVIMGVGSKGYGSSNIPSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAX8</accession>
    <name>A0A2T6ZAX8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isoamyl acetate-hydrolyzing esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000491">
        <property type="protein sequence ID" value="PUU72652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAX8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAX8"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="260" mass="29100" checksum="B715F8F36DF5F7BC" modified="2018-07-18" version="1">MAFADYDKIVLFGDSITEASYEQARGFGFGAALTDIYRRKIEVINRGFSGYNTLHALEVIPKIIPPPATTSRIRLITIFFGANDATLSDRSQHVPLDQYAENLKRIINHPLLVAHNPRILLIIPPPICEYRTQDHDLAKGVVGAQRLAANTKRYADAALEVGKALGIPTVNLWEAFTQYAGGWEEGNPLPGSKELPKNEKLGELLRDGLHFEPKGYKILYDLVLETIRGNIPELDPENLEFVFPRHENAPKSNFYTYGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBF8</accession>
    <name>A0A2T6ZBF8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1069483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000461">
        <property type="protein sequence ID" value="PUU72813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBF8"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="51"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="281"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="703" mass="77380" checksum="707FA5AF4883562E" modified="2018-07-18" version="1">MSKMVALNQCSSVTGIRGWGKLISGRGGPCLEKYDADVGDNQQNNSSLAVDSLCDQARGKDITIGALYCDFHAQLEQSTTNMLGAIHRQLVCGDRIPDHILEAFQNANKLFGDRSLRLPDVVECLKRTIKSLARVFICIDGLDGCTPQHRRELLESLREIVRESPNARVFLTGRPHINDEIVRCFIEVARIPLSSTHEDIKRYLEMRLNLDVHPAMDGKLRAHIMETIPKMTEINLLLVSLNMDTILGETTISRRRKKLDEIARGKGIGDAYAAILSQIMAQPRSRSKLGMDVLMWMSHAERPLHVEELCHALVVEEGSPSLNINKIRANTAPVGEKIYDNCCLGLVTVESSSSTVRLVHNTLQEYLSHNPNLFLNPHSVIAGVCLTYLNSRHIRGLSPTLRSAPSTAPFLIYASCYWGAHARRETTESVKILALKLLYAYDKHVSSKMLLLHGIGGLDQPFDSEDTPRGFTGLHGAAYLGCTEVVVALLEANTCDSQGADFNGNTAIAWAAGRGHEEVVRVLLERSDVDPNTANATYGQTPLSLAAKNGHGGAVGILLERNDINPNKADKWGQTPLLLATENGHEGIVGMLLERSDISANKVDEWSRAPLSLAAGSGHEGIVKMLLERNDVNPGHSDNRSQTLLSWALKLSWVLKNGHKRIARLLREKTESVLKYAARPKPTESFPEPSERLGPPSKSTRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBL8</accession>
    <name>A0A2T6ZBL8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_611824</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000450">
        <property type="protein sequence ID" value="PUU72873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBL8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBL8"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="264" mass="28645" checksum="3E26B69D3C0CFF0B" modified="2018-07-18" version="1">MLLLLAFPAPVLTMFPVPVLMFLFPAPTLTMLLLLPVLSILPPPFIPWLPPLICIPLPPPMFSGELKHPIASDTTVGRRILLFAEEWPNQLSLYGNILRLCTSVLIKALSPEDEISNTEFWHSMYHLLNMFPAVESPRANKNIAIMVKDYAFKYAKEHPYLLALNIGLTVVGFSVPPFLGVLGFTRAGVGAGSTAAAWQSSLRAVPKGSLLSICQSIGATGSAPMITAAANVSRWALGGFAALQEMLGRREGGRDEDEPEPDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBZ4</accession>
    <name>A0A2T6ZBZ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1096238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000440">
        <property type="protein sequence ID" value="PUU72934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBZ4"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="314" mass="34454" checksum="7FC39BF328509224" modified="2018-07-18" version="1">MLLLHPHSSLRRLSRNFYNTSVHLSTKRIPIPFKTPLQPSLHITEKCPPSCACSLESLPEDLDIDRVTSLKGTMANYYRHLLVCTGHSDWASKIELDIAEPGGGLAGRIKELTAMRGGGRKDLRDPFSPTLVTNSSFEREPGVEEGRGVASAYIFPSGVYLPNIPLEDEGVVELVRRFLLPGGEDVESTLESREVMETVVLVCSHNSRDTRCGLVAGPLRRQFEKELAERGVLLEGHEGEKGRVGKVRVGFTSHLSGHKFAGNVVVYRPDGLGVWYGRVQPKHVTGIVAETVLNGRIVGELCRGVVEKSGKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC87</accession>
    <name>A0A2T6ZC87_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1006266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000419">
        <property type="protein sequence ID" value="PUU73056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC87"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC87"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU73056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="361" mass="39512" checksum="A56275FC00F6C25F" modified="2018-07-18" version="1">MGVPLSRPMVEKRSESGEDNRLAYGISAMQGWRVTMEDTHAAVLDLQNPDDPTKAGSEGRISFFGVYDGHSGEMAAEFCGQNVHKILAKQPAFKDSNYEQALKDGFLSTDETFLQDPQYRGGISGCTASTALITDTKIYVANAGDSRTVLSVNGRAKPLSFDHKPYNKEEKARICAAGGFVDSGRVCGNLALSRAIGDFRYKMKADLPPEQQIVTAFPDVVIHEVSDDDEFLVIACDGIWDCKSSPAVIEFVRRGIAARQELHTICENMMDHCLAYSDDGYGGGSDNMTMIVVALLRNTMTKEEWYDLIAKRVADGDIPREFDIGGAGHITMLDDESEASIDSDDGEVFDDVEGENDDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCD0</accession>
    <name>A0A2T6ZCD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_574963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCD0"/>
    <dbReference type="OrthoDB" id="5431159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="885"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="968" mass="107797" checksum="72C6DEA5A7A688BF" modified="2018-07-18" version="1">MAHISARQTFALLPPPPFPCGYFWDAEEIRHQEHLHRVSHAQLLYSRRTDSPEAMRVYKDFISEQNAWMAEQEELIEREAQVAMKAHIDRASRWAEEWRRLESGEAVEDVLMQTGATLITKSPFRLGDPVTCVDTDPVSPDDDSTPKSISTLNLPESLIDWRQSQSSWKGLQIFKLNCTPEQFPSSVQMDGTTATRIQNPVSDPAEITRELQQDLSRQILFKPLEKNNSRSSGVDTHSERNKFVVKPIISFPPPGLGPPKKSRAENFATSKLPPAMKSLIQRGIGLAGGEVIKICSHKRWTDDGDLLYEILWKPHDLDIPPLELWVKSGDFMDANKRAILDEYHQRNKLGIVHWRSRLKKKLRTSGSLGVKEIKDALDKRKRSLVASGRYDDRAVELLGKCRWVMRGEWQQRGRGWAAGIEVTERWKKAWQDADEAERIGHSPEREAAIGATANPDGNDISCLEEVEPKDVPFPAMARTSGSPSFKQLDGGHVIDLAHDLDSQWILGDNHKITRKDEEEWRGFFGGINHLDPVMADITDSSTIGGISEPGGVIGTFPKAVETWCIDHSESSTLEVRNTNKTKGEFVNLLKRDRFARKSKSEAISAPVSVQSVSGTGSCLVHEPETFFSRLLVKDRHQNNSADAVTTAAYKPILQLSEVTEIPGGFGRTPAIVSTPLDGETSERHLKSGYGMPQLNCTTTQEEARRDEASAQDLITGGTITGVVAIQVSPSTESLAESEAGQSGMASESTKIIGEQLDEDWPVRFLELFPHTLGLSNLLAGAYSGDCGPMQAAEYIYSPVASFRGGGGHISSLDGEEATDGGLGGNTEHRRESDSSLKKAKRELGFENDRDPNPPESVALPQEALSSQDGVSLLLTEVWSVHEVALTKHELAMQALNDSCERTKARGKELKSKKKEEELTREERREYRKLKKLLVQYRVTRWLLGKIGILVKRHRQEQRIRGASPSFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCS0</accession>
    <name>A0A2T6ZCS0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1005178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000390">
        <property type="protein sequence ID" value="PUU73297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCS0"/>
    <dbReference type="OrthoDB" id="63989at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="6">
        <location>
            <begin position="133"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="249" mass="27795" checksum="5D5B3296ED9D9B8B" modified="2018-07-18" version="1" fragment="single">PRVLISNFGLCKKLGDKSSFGATTTHAVGTSGWRAPELLVDEDSASKPIFPSQHLLLLGCVFYCILFRGKHPPGTRWHREFNIINNNPDLSHLALLGLAEHEAKDLISSMISHDPRKRPDATKVLIHPFFWSAEKQLTFLLDVSDRFEVEKDKEKATSPEGWYKSPFIPLLERNTREVCGGGAGEWMKRLDRLSLAELASNKRRGYDGEKVLDLLRAIRNKKHHYQGMKRPTSRDGSGGVSAGLGPGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD11</accession>
    <name>A0A2T6ZD11_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1095220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000385">
        <property type="protein sequence ID" value="PUU73363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD11"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015414216" description="Secreted protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9090" checksum="2C7D7BE6BCAE02E9" modified="2018-07-18" version="1">MHLLPILLNLVALSLSFGPGNRPPLQPCAKRSGTPATSSTVRQKGYTSTITGMPARVPELLAYRCGALRAQQNSNNILLNKSGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDN4</accession>
    <name>A0A2T6ZDN4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1003928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDN4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDN4"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="194"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="464" mass="51962" checksum="7C325E3E69823DE1" modified="2018-07-18" version="1">MSTSRSIAPGRPETLTKEEEAKLKQFWNAALKVFGTSAPEDSESLPQAPATEEENGNSVTSPTSPTSPDKRKKGTLGRLLSRKEKTGAPKKEAVAATGAGADIVIDASDDKYGHTREFKAALASQTPAELRDAFWSMAKCDNPDALLLRFLRARKWDVDKALVMMVATMNWRSKEMNVQAVVGKGEGGAAAEKDNDFMMQLRMGKSYLHGLDKEGRPICFVRVRLHKQGEQSEESLERYTVYIMETARLMLQPPVDTAAVVFDMTGFSMANMDYAPVKFLIKCFEAHYPESLGICLVHKAPWLFSSIWTVIKGWLDPVVASKIHFTKTTEDMEVFIPKEKIPKELGGSEDWTYTYVEPIPDENSPFEDGARRNMLQSTREEQIRKYEAATRAWIASGEAGESAAAERRAISRELATGYWEMDKYLRARTVYDRTGVLLPNGEVNFYNYKKEKASAVETSEDDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDY4</accession>
    <name>A0A2T6ZDY4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1103792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000351">
        <property type="protein sequence ID" value="PUU73711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDY4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDY4"/>
    <dbReference type="OrthoDB" id="5342685at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF30">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="263"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="887" mass="95180" checksum="B8935A7A4C68C3A9" modified="2018-07-18" version="1">MSSIFTFNPSPPKPASPWANNTPAHPTPSTTPRPTTGSPDLITDDTPGHLRTNNNSGKIRNHFMEDGEREGIVTTNGETVKGLAAEPQMGATEYKLSLVRGGKSEARLDQLVTQLLWRLQQSSPYHANSLATKSPEAISSLVQESQGALYEIGVADDGKLIGLCEEELQASLGTLRIMAAKLGCTVRILRRETVDQMNGQCVEEEGPSGSEESFGIPKVGDPLWVVEAFVQPGHGQNTRLRGFVSEREAVRPGGRGKTEQLRITLTGATTCGKTTLLGTLSTGEFDNGRGKSRISLLRHRHELASGITSSVTWEILGYMPEDSKAEPKPVSCNRGPPRLVNYASGNVSSWTDIHAAADGGRIVFLSDSAGNPKFSRTTFKSLIGWAPHYAAFLVAANDDETPGAGENGERSSGLSKPSLAHLDLCLKLGLRMIVIFTKRDLGTKTGLKKVFAHLLTILKQNGRKPATLSTSASIKDVLKLVEGDPEHTVPILFTSSVNGQGVDLLHELMMRLPVPEPPKTPAVAMEEDGGLSTLFHLEEIYGFQPAHGAEDGTGGAVVGGHVKYGKITIDDELLIGPFPPVDHANSPPSIEGTPATPTPHPLLSPSTGHFSGLLSKSPDSADEKRAASPKRSGPKFTHGDITGNSNTSGEEWEWKLVKVVSVRRLRLPVNTLFAGEAGTLGIMPVEHEPHLGTPLAVSVLNLQLRLNGIGDETESRNGNGIKIQNGSPDTPANGAKAVTFASSPTVTPPLLSTKLRKGMVIFNRSSSAVSSWPRAYTGFTTNLGDEANSLIPGSSVAVYIASIRAIARLISIEPPRVRSDEIFSLDDEEEIKESEHVDHEGTRRKFMFEFDHARAEWMEVGDRVLIVPGGGKKGLDAFVGRVVERQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEM7</accession>
    <name>A0A2T6ZEM7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1134100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000331">
        <property type="protein sequence ID" value="PUU73958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEM7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEM7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="220" mass="23862" checksum="25468679C2C64BB8" modified="2018-07-18" version="1">MEDLPVSSSPISPEEQDRIRRERRHAKLKEGSSRLNRITGAQGQTFCIEETPAAREATPDPPDLDISADYYKPKTRQQGPPPSPLRSSSLANAQGQQGPLSGSGGPDVLDDAAAYGLCGRTWSDGWRSWSDGWFGRPKRSGDGDGYTSSRDSTNAAEGGPWEKALHVLSSLCLGGWVLLGTGWSFNGSALERAKSADMITEEAPPLFWYFTTMELVLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF06</accession>
    <name>A0A2T6ZF06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1103681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000326">
        <property type="protein sequence ID" value="PUU74046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF06"/>
    <dbReference type="OrthoDB" id="5385983at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="31507" checksum="C93959EE9E80B30E" modified="2018-07-18" version="1">MTNGLSLEKLPLEVIHHVFSLLSTRDLTLLRLTSHSMLSAATANTHWRRRFFDSLLPSYAALTDISSIAHNQWAFQLVPDGWFRAYITVIRIAREDWLHTNEELKGSTWMVFFKSFLREGGAKSDDAAAHALVELTHDLTSVPIEGLPLRGSSWHVDQNKSLRFSAYPPIVPSRDPHTWSLSVLNTTILEESNTAGLIDEDKRQALESSVRDSLQAIQDRRKSELSARFRKLHLLRSEARERSMNCDYQGSSNSGSSRSGSASGGGDERIVVSPLGEAGTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFJ4</accession>
    <name>A0A2T6ZFJ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Elongator subunit Iki1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000314">
        <property type="protein sequence ID" value="PUU74226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFJ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFJ4"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="11971" checksum="F8B631C90A3E90E5" modified="2018-07-18" version="1">MPPQSLHHRRTHNLLLITRLLSLRDGVSPFTLLLDSLSQSARPLLREYIRRQQSGTRIIFISFETVVAPEGVSVFIRARGKELVSLQREIGGAVGGSGSNRLSPQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFQ4</accession>
    <name>A0A2T6ZFQ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1103510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFQ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFQ4"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="361"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU74302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="413" mass="43410" checksum="D51205FAB7D1ACCB" modified="2018-07-18" version="1">MSTHDMSSGLAARRQQHPLPQFHLNTTRAPYSSFGGNSVLTPPPIGPNEITSPLSSGGSSAGTVSAMGPFSPVGYWPATSNSSPYGYGSASTNASYTSGGIQGSTNSSFGVRGFASPGVTLNRGNSRPSSPATGELVHPPSFDNSSPYTSGMPISTGAGGHPTAAVAGSGLPSIGPGSNVHGSYAAAYLQPSQHSNQPHPPINNQSQQNHDPYSPQGSLPPPTPSQPYYGQQQQQQGLQMSPSSVMGRQMNSGPQYPPLVPLQPNYKPQYPLPGVGGQVMGGILHGHPAMMPHHHPGAHHQQQAERPFKCDQCPQSFNRNHDLKRHKRIHLAVKPFPCNNCEKSFSRKDALKRHRLVKGCGKNDHLQGQSSPVAAGQDSKQSPSVSPISTRNPGPEPNTSPPGSAGGMIKHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG43</accession>
    <name>A0A2T6ZG43_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1133318</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000300">
        <property type="protein sequence ID" value="PUU74426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZG43"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="1520"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="3667"/>
            <end position="4003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="262"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="701"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="905"/>
            <end position="928"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1559"/>
            <end position="1636"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1648"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2006"/>
            <end position="2060"/>
        </location>
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        <location>
            <begin position="2102"/>
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            <begin position="3299"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="270"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="707"/>
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        <location>
            <begin position="2639"/>
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    </feature>
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        <location>
            <begin position="2864"/>
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    </feature>
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        <location>
            <begin position="2995"/>
            <end position="3005"/>
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        <location>
            <begin position="3323"/>
            <end position="3340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3345"/>
            <end position="3362"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU74426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="4003" mass="444077" checksum="3BCD9704420F7EA8" modified="2018-07-18" version="1">MKIKKTATAKHEATLSPFLKSFITTATSIPIPELLPFLSKFPVHWPFPRGDLYHWIALLNRFDSILEEQVQKYKLKEGPQTILWERQDEELVIGILKFSRMLVENCGNRSLYGSSGFINDLLNTTSLHVLEASLRLGSRLAQRYHTSRTRGASQSTNAVLLASHYNINLERVSKLATPFLKSIAVTGLASSKNVSTKAVVPIYANDLARLARDERPIDSAEVLGGKGKGKAPEGWEGPWEEWGGAYVSYYVSPTAQKAVTVSGPGAGFVPREPATPTPARRTSLHHGHQTPGSAHSRRRSTDDAIADSSDPAVTGGMQTLEIPYSQIKAASSLEDILKSTLPEIPVDTHYDLLHRLRVASALAGTAESRRQILGIRILALTNLAYVYSENQFTTKILQPDQDEPRRFQLVYQLAELVHSGDIKGVSGSGKEIPRWLQTLALGGLEALARHKSKTADVCAALSVNVNHGVLLYVVRKAVEELAVEKGEDEYDKEAEEWREALFTLVGYLPTTTHAGSLLVSAGLIPILVELLQLRTKKALRNIPKAVSFLDSLIYNVQNAFQALASAKGLDVVVDLVSDEVKAGLEEAETGKGIPDEYKSSTTDFKIGFYRQQTLKMVFKFMQHMMAQSGGNADRLLRNLIDSPKLLSALKVVIENGAIWGSNIWSTVVGIVSAFIHNEPTSYAVIHEAGLSHALLETVTGRSGLAEEEAKRKKDEEDRGVVVDNASTAAAADVGDEPMEEGSTPSESNDKGKDKEDESSEDRKKDLPPRLHTPAAGIMPSVDSIGSIPTAFGAICLNASGLALFQTSGALETFFEIFESADHIKCLTEHELASVLGSQFDELVRHHPTLRENVMKVVIEMLQRVEIIGRKLAEEKGMGAKLWIEDGYGGMVVAGGRKALVGEIHKHSPEGSAGSSTKPQRSDEEDVEMGDADVVASTITLEETSLDGSPKTEVVALSDIIDEEAEDADRNQPSIANFIDAAGRFLEGFLANANLSKDFIKRGGLDFLLDFYTVPSLPYDFATSQANQMMSRVLQVCSENSPSVTVAATLKHAQKAIDQLQPLLQHDKKEAFFAPLTDQKAAILPPRLQGGIPAQDDHRAAASSGEGIVEGIEAVQEKLSQDVRPSGTKLIKDLVTVHSLCYLLQELYGQPLFNVRLTLSIFMQPENEAIVSNLGALHRMCVWEELLLQNTIPDTWNEATRVKNSAGAAAASIEEEVIPTVVATSAESQLQSPRSQDEQKEAEKAVVERDGKTPWFRNVKTIRFLISQIPSSITPFLQGLARSLISRRSTDLLHKQHAFKIAEAISESMYDHLTWKRLDSSDSVTDKYGYWIVMLTSITSLLLEEKGSGQVITITLVTFKQNNGIKAVTDILETFWGEVQDLPALGDAEQIGKDSHQRMAHAYGGIKIILSLFTHLVSNKSVLDSPQTVALQTRERSSDTPRPDFFNPHQFLVELRASILPVVRNMWDASSIEKASCSIVKSVIEILGIVLKADSESGAFTRKELEKKGRLSNTISWRTMEPNEEGIRQLVEMGFTRENAMAGLLRGNGNVNTATEWLTSQGVRTPQRGSQISASSSRPLTAESHSTDEEGTDVDAAREEPIVPAQSEGEVERGAAATEPIMPPPAPPAPAVDTGVPPADDGVVAMNIDESNIQPPPPSGEPQASESAEISPSAVEKGKAKEGEKVEPPQVITIEELDELRSAICESLIDRSLDVLRVHSTVTFELSSLLTSAFGKVSESSDVRKEVASTILQSLMSLQADDLRPCAKTITSTSHLLGLVLQNQDFFDACLEDLRDQIPALIEFIKMNKGEPAPWIASILLVVEKVLSESAQPKRVTFTSPPSDQEPENIAELNSYKISDADQSALFEAVMGVVSVIGKDEVLPLAVARILVLLTRKRELAIRMAKEDNLRCLFHMLRCQAGLKTERIQASIMLVLRHIIEDKEVLKAIMRNEIRTWFQSRGSRQIDTQSFVRHNHHLVLRDPDAFVELVNELCKLTRYDPHLRSQQIAIKETERPKPETESKPEAGSDPAKETEEPAKETEDKEMVDKPKPVAEVKPPGLENPDGVIHFLLSELLAKDAIDSHLPPNPPKEDIASVPMDVQMEQGESTGKSTEVSQANSFSKPEKPEFKAEQHPKFIYRCFILQALTELLSCYNRAKIEFIGFSRKAAPREAITPSKPRSAVLNYLLNDIIPPGTLIHTEDIAHKKRATTSQWAILAIVSLSAQTGESSSAEDESNLLFVRKFILESALKAFKDASSSLEPLDAKYSRMMSLTDLFFRMLSARPNHNHSPGSAPSEKSQQQIARIMFEKNFIAALTGSLADIDLNFPSARRVIKYILRPLKLLSKTAIELNEISSISTPGATDEDEISTATSISDIGDMREDTPDLYRNSTLGMFEGEMVDDEHSSYDEDDYDDEMDDDEMEMEEEMEDEGDSEISDEEDEEGEGMDVEIVVEAGQESEDDDGDDDDEDSDDMDDEVEILDEMAQDQVHYGSGGEEDWQSEGSEGEEDRGDEILPDNDIEAIVRPPGGSDEAPEPGYEDRDDGFIDDDAEEDDEDDDDDDMDEEEAMIQEDYEDDEGAFSAVPWGWADETGEAPMMARAHPRGHGGWYPLGPRESPVFMTNAARPRHYMGGTAPRATDNVDQNPLLQQNSNNEQANARPTHNRSQEFMTDWVQAIDGMHATGGGVSMINTLMSLMTRSGQHLPVLANGASIQFQAALPHLAHHHHHHGAPFMPRELRSMFEAARPQPDVQRHHREDPQTAVNSFVPTLTTGRWTEESRLLFGSSAPDRAQRVVNAILVLLVPPAIEEERITKEKQEKARLELIQIEEERKKKEEEERIAREKAEEEERIRKEAEEREAAERAAAEAAEAAELAAAAASESDAPEGENSPKEGEAMEGIEATQGEAPRVEAGPSDPPAPRATVMIRGREMDITGMDIDPGFLEALPEELREEVLTQHIRERRAAAATNDQPSEISREFLEALPDEIRDELLAQEAADRRRRERDQARPPGASTGPADLDLASFLATLEPDLRQTVLLEQDDESLAQLPQAIVAEANQLRGERRFNQFVEMPRVARVSGVRHPGEPEPKPVKKPLRKSVIQLLDKAGVATLLRLMFIPQVGSTRLTLHEILLNICENKQNRAEVVNLLLSILQDGSSDMAAVERSFAQLSVRARQAPATKTPTTAIKRTGTGLLAQTSSEVSPLMVAQQCLGALLFLVGYNEHIPSYFLNEHDISVGLKRSTSRKGKGKEVPPPKASKYALNTLLSLLDRRLITESSTVMEQLSVLLSDITRPLTFLLKREKKKPSEQKPAESVAEAEPTTMEPANENTTVATETSAAATTEGQSSENKDEASNSDRKKDDDRRRRLRHLVPPVVPEHNLRLVVNILTARECSSKTFRETLATMQNLSAIPEAKVVFGAELIRQAQVLGGTILGHLEVLVHQIKHAENGTEIQGMALSNFSPASSDQAKLLRVLTALDYLFDPKRPSREIVKDNEPKDEESKKERDVLSNLYESLTFGPLWSKLSQCLSAIHERNDMLHVATILLPLIEALMVVCKNSGLKETPRTQRGQTPMSPVMAETTMENLFFKFTEDHRKILNQMVRNNPKLMSGSFALLVHNPKVLEFDNKRNYFNRRLHTRQGSRDPHPTLQLNVRRDQVFLDSYKSMYYKNGDEIKYAKLSIRFHGEEGVDAGGVTREWFQVMARQMFNPDYALFIPVASDRTTFHPSRMSGVNPEHLSFFKFIGRIIGKALYEGRVLDCHFSRAVYKRILGKSVSLKDMETLDLDYYKSLVWMLENDITDIITETFSVETDDFGDKKIIDLVPEGHNVPVTEDNKHEYVRLLVEYRLLTSVREQMENFLVGFHDIVPAELISIFNEQELELLISGLPEIDVDDWRNNTEYHNYSASSPQIQWFWRAVRSFDKEERAKLLQFVTGTSKVPLNGFKELEGMNGFSKFNIHRDYGSKDRLPSSHTCFNQIDLPEYDSYENLRQNILTAITQGAEYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG98</accession>
    <name>A0A2T6ZG98_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000295">
        <property type="protein sequence ID" value="PUU74520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG98"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="269" mass="29264" checksum="1D6F815E27258A55" modified="2018-07-18" version="1">MPPQSLLKGESLCRAVLDIWNALTLKPDSGSVRHAITEPFNDGVLCHPVCQPPKGRSNTSIFHGATESSEGGPNSGRFRHMITEPFDDGVLHHPIYPPPKGRPHRSIFHGATELHEGGVIMPDSGSVRHAITEPFYNVVLLHPICPPPEGRPHTSILHGATESSEVGPNSGSVRHAITESFYDIVLHYPICPPPKGRSHTSMIHSATESSEDGIPGALGMRSWSPFMMSFYAIPSVHRQKDVPIRAFSMALQCLLKGQSLCQVFVVQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGH3</accession>
    <name>A0A2T6ZGH3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S1/P1 nuclease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1068072</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000288">
        <property type="protein sequence ID" value="PUU74601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGH3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGH3"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015452579" evidence="9">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="356" mass="39378" checksum="096C9586F1D8844E" modified="2018-07-18" version="1">MRPANFLPALLLAPLTSAWGTLGHRTVALLSTRYLLPQTAKWVRDLLGSESIAAASTWADGYAHSKDGKFSAPWHYIDSKDNPPHTCGVNYSRDCKKDRGCIVAALVNMTGRVADERLSRNERGMALKFIIHFVGDIHQPLHTEDLLRGGNGIHVTFDGRKDNLHSVWDTAIPEKYVGGDTMQDATTWSNNLHTEIETGKFKDPSIKQAWSACLDPTTPQKCALVWATESNRWMCDYVLPQDYPEGFEGSELGGDYYDGAAPIVDELIAQAGWRLAGYLNAILAGETGLPIGTQSDGFWDQTGSDHGRERPGREERQGREERPGRGDREPRAPPRGPKKLMGQIGGWWGNLRAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGH4</accession>
    <name>A0A2T6ZGH4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1032805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000289">
        <property type="protein sequence ID" value="PUU74585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGH4"/>
    <dbReference type="OrthoDB" id="5341894at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="54329" checksum="70238940BA20336B" modified="2018-07-18" version="1">MSAPNVPEIPGYYYDTERRKYFKILSDHAGPSSSSGSPSFYTPSTIAEREAKKIKFKEEARQDLLRLQYRPRRSISKSPYLHWTFDRELGLGTPVSWRAAHKKSMVKQLVYKEFIPAERVKQGVSNLFVQRMGGTVYFVIGMENGSIVSFCANGVGARGLGLGEGIKGFKDRDFWKSEMEQKMQLDGEVKEGRLIKSDASVRNWDFKLPGMVTGTVAIENGENNLEVLVSSLSGAFAHQLLSKTTDFLPRFRHLAGTHRYSLRTNVSDQRPTLSMAYSPDKQTIFYGLEKGVAFGQADGQARPRGVITNLSTDIFATYCLPPDAPSSHAGFLAGGRDGTVRLFDVRTNPRTSAPTVLNVGSVRHIQGLGQTKLVIRCVDSCAMYDLRAMGQDRLPPGEKSYCLSRFRVPDSDGKKGGFDVYHEMGLMAVEGGGIGTGCGGSSSNEKAVYLFDIDSTDLLGKVPPGQVQFLRPEVGDGWPVVAVAGERGVGVYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGK8</accession>
    <name>A0A2T6ZGK8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1157591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000288">
        <property type="protein sequence ID" value="PUU74609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGK8"/>
    <dbReference type="OrthoDB" id="5412343at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37470" checksum="160B9875019DD21F" modified="2018-07-18" version="1">MNPPSVPHGRPENMTELVEAYLQAPGVIIQRSLPTETLRVPFSPTYNTKFILKRFQSCDDLFDEIAAMEHARSAFNSWMPGSHIVPDTYWKSEPSAMIAMEHIPGTNGSEVGMGFWTRSQRRGFVRQMAVIGICLIWGVRDRASETSTEAMFRRGLRHKSAAAYDREGIDEFFSNALSGIFAPPGPLLRNFRFIRPCEISLRGSKIVAITGWGSMLNWRGGQGAGDISGLDVLNDTPPPGYEALGGPDWDTIRAYSGRIREADFMEALSDDESDICDGEKESEGLPEDWYHQPVWQLVSECVCRCELRAKPVPIGEYLGWAKRDEEGFRKELTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGL8</accession>
    <name>A0A2T6ZGL8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000287">
        <property type="protein sequence ID" value="PUU74619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGL8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="169" mass="18400" checksum="EB56157647C84259" modified="2018-07-18" version="1">MTSKTKRTRMTGMRRLMKTRQWIVLEGTSRRTQSSSKITTKVEWCTRVLDTITRSEATPMGLRTRGGAEETCQHAEIDSAMNSLYAVSSGTFAECPAIPLSPISPTVPKALRTSDTTTIALALTIPDAAYILRPSATPDIATLPKIYLTVIASLALDSQNVVIARGLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGN1</accession>
    <name>A0A2T6ZGN1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1103338</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="NESQ01000283">
        <property type="protein sequence ID" value="PUU74651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGN1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGN1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="168"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU74651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="184" mass="20244" checksum="0652AED14A4B6055" modified="2018-07-18" version="1">MPRTLFFVTGNANKLAEVSAILATSGISIQSKALDLPELQGTIEDVSKDKAKRAAEVIGGPVLVEDTCLCFNALKGLPGPYIKWFLKDLGHEGLVNMLAAYEDKSAQAVCTFAYCEGPGQEPVLFQGRTDGKIVPARGPARFGWDPIFEYEGQTYAEMDRVAKNLISHRFKALEILRKWMEAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGZ6</accession>
    <name>A0A2T6ZGZ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1132648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000275">
        <property type="protein sequence ID" value="PUU74763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGZ6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="143" mass="15656" checksum="20AE628A5629E0C5" modified="2018-07-18" version="1">MTAFYAIPSVHRQNDVSIRAFSMALQSPLKGDHHASQILRALSMRSRSPFTTAFYAIPSVHRQKDVSIQAFPMALQNSGGVMDAIMKPFYDGVLHHPICPPPKGHPHTSIFHGATESSEGVVHMLSFVGCLESANFKAGFRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH38</accession>
    <name>A0A2T6ZH38_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1110441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000272">
        <property type="protein sequence ID" value="PUU74807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH38"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH38"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50342" checksum="EDDC68CF73C7AC64" modified="2018-07-18" version="1">MDFSAMLYRRPALVSSGSSKHSGSFEPKALFSVNSNSSHSFRIPGIPDALSFDKIIAGGTCPPMTCRDFMQYLLYVEHAAENLQFYLWLRDYTERFNALTENEKALSPPVPINPLDPRLGPKHGLRSGNRATQFLSNAFSSPSQQLAVPSLTKANPFTTPPRTPDSSGGSGFEQGNLAIEPFSSVESVGLNQINHKQMAAEAYQSIGMEWQPFSVHPFREEVTRVVAIYIAEGGPRELNVSSRDRVATLRGISHTTHPSAFNPLKKTVEDALRYQAHPNFVRWSICNGNPPRVFFARCLGVGTILVGLMIGILLTLSNCSRGWRVMAAIAWIIGIATLFAAYKGMCVVLHGLHARHIRPWELWADEEAKDSFGSKEPLESQAIPNSYEDEPWRAQYENRNLIRRIFDKQVWIEEPALRQIQDVIFLQSMIVAVIASAVLSAIFVTVPSGGYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHL1</accession>
    <name>A0A2T6ZHL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1110366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHL1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="20666" checksum="A415B3644B0FA1E2" modified="2018-07-18" version="1">MPRLPQPLSDPVNYKRSGLRTSEAGSNKGSNETITFPIPKIGSTAIRVPYEYKSNQPTNQRSPSPLYSGYSADEVLSPSLTHHPQTGNTGRTMLEMKVNPDRTRSLCPPTHPQYYFLTAATGRNTTDKRQYDAVYGQSSSPCGMVLVLVTLFQIQTDLAISRAAETVENFVPPLSVSKTCLIIENATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI73</accession>
    <name>A0A2T6ZI73_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1067610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000245">
        <property type="protein sequence ID" value="PUU75198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI73"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI73"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="21297" checksum="3E61697DD29B7DFB" modified="2018-07-18" version="1">MRTKRFSSSRPSVAGHTNGGIPDGEGKEKDEKCFSGLELLRSQVMPLSISANTASPLRRSSLAGHNIEETTKDAFSSNDEYALINKNPDEDDGDSGFSSHLRRGGSVTSYDTSYDAHPDNPILWGGKGGAYTSTGNGIGGHGPVAMGGNRRTPSGLSMPIASGEDYSYRGAAVKYDVFYVFLLSSGIFHFLSWLGFPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIC9</accession>
    <name>A0A2T6ZIC9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_368219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000247">
        <property type="protein sequence ID" value="PUU75164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIC9"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="21523" checksum="B400FFC9AF083BDC" modified="2018-07-18" version="1">MEPAGSSRPSHNKKPMFGDFAEPIPHGKAPRVTGVYAPTNPVPIPIKEKLDENLNIRGGLERIDYAGRQQGKIGSKVGKGPRAGLTAMTRMEGFAEILHEEVEKRRLVPDDIVHWGKAVDELIEGPDKRHVRTGTPCKMFNWTEFFALDIVAQITADQSAGFCLAGKDADNTAYGVRVILRVIGVLVQLLWVLSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ63</accession>
    <name>A0A2T6ZJ63_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1090198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ63"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ63"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="287" mass="31927" checksum="691B93F270AE94C1" modified="2018-07-18" version="1">MASRTVFARAGLSGGKRVGVLDDLLKVSLAPGCSRFMATEVEGSDVPSISPSMRVLPPEPPAEIPFAIRKPPTVLTTIYRFPTLEPLRFQSFPTTFLHLPTRRDILHRAITYEGDAARSGNASKKWRGEVHGSGRKIRPQKGTGRARLGDKKSPMLRGGGVAHGPKPRDFSTDLPKKMYNLAWRTAFSYRYRRGQLIVIEDTLEIQANDPGLANSIIKKNGWGNENSRSLFIVNEERPNFMDAMEGLGPEGLVLTREEVDVKDLVSFSYINPFRCPLDYGGTSLDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJM2</accession>
    <name>A0A2T6ZJM2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000218">
        <property type="protein sequence ID" value="PUU75690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJM2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJM2"/>
    <dbReference type="OrthoDB" id="5279705at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17986" checksum="F3A3C1C7C56FC8D6" modified="2018-07-18" version="1">MLPSPPSSPPEFLAPKRLFKPVPSSHSREEGREARRNLFLKKVRDARDEKLLKARGGEDEMMRLIFVSEQKRWEASQARTAASIPTIYEEEELGMGNEELDFQAEESFFMDQDEPGPSDDLDEMLDRDGKELEDLLSQLDLQLDQVMPEANGEMMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJZ3</accession>
    <name>A0A2T6ZJZ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1102710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJZ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJZ3"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="309" mass="33969" checksum="DEEEA16AE1BA5530" modified="2018-07-18" version="1">MLADRSLDPELRPLAVSDIASTESSLSTLAAAITQSLVPPHPFAHLSAMVEIRPGAGGSEASLFAGDLLKLYTTYCANVRHWPLSMVSLTASMEGGDGVQEAIFEVQAPGAYEIFRGEAGVHRVQRVPATEKQGRTHTSTVNVVVLPSFPEVELGEGEEDPDSIIDMKDVRVDVMRARGAGGQHVNTTDSAVRMTHIPTGIVAAIQDSRSQHKNRAKALMVLKSRIAEKRRAEREAEELALRRSVAKVNAGRSDKMRTYNYIQNRVTDHRCGFSLHDLPGFMNGETLDVMIGQVRKWQMERDVENLDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKL3</accession>
    <name>A0A2T6ZKL3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000206">
        <property type="protein sequence ID" value="PUU76025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKL3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="15791" checksum="ED4803721602FB97" modified="2018-07-18" version="1">MAAATFLLPAPAYVDIPPIPLLYPYRDPKLFFCADMELKEEPAQVKEEMEGSKAPEESGVAEEPQAVEEPEHTEEQKEIVEADQTNKPGGATEVATVAAPTTATSLATPVAPTTPFAKPPVDEPSSPVGNETDPPPPISAKNSEEGPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKM1</accession>
    <name>A0A2T6ZKM1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_286106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000205">
        <property type="protein sequence ID" value="PUU76040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKM1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="19925" checksum="48EA402B48C093B6" modified="2018-07-18" version="1">MPMVGSYAQSLRSYFERYRCGGALPFNLSDGLKCAPPSAAWENADTIQAPYCRVHPTRIPGSASLQIKVIVPRSSNHTAGDSSRWAIRPRYGTSNRDGNYVPNFHHHTKNEPAITVDYGKPGYQRNRSEKKPKDKVSSGVGRRNTCPTLMSASSRIVSLSRKRNPSIGGFFSDRNIVIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKS8</accession>
    <name>A0A2T6ZKS8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1029474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKS8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKS8"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="19536" checksum="092BF5633CFAD3E3" modified="2018-07-18" version="1">MPITTVQRLDAPSSYFEKRERRRSTSPKADPLKDASTLYVGNLSFYTTEEQIHELFSKCGEIKRLVMGLDRFTKTPCGFCFVEYYTHKDTLDAMKYIGGTKLDERIIRTDLDPGFKEGRQYGRGPTGGQVRDYYRDDYDPGRGGMGGGSRGLLLKGSGSSRGFCVCKGRGGFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL26</accession>
    <name>A0A2T6ZL26_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1116033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL26"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL26"/>
    <dbReference type="OrthoDB" id="5219809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="33295" checksum="22EB1A19B7BE2541" modified="2018-07-18" version="1">MSVTDEDTWCDTHIYASESGDTMLGGLWASEGMTNANLYSMLEIFCFFTDTFHLHDNRKQLVRRDEQQLQPGNYFCCSVSVTDEVPLICAISLPSGTRVASFRDAVLQRDRRCVITGRQAIFAHVGRWRGFEATHIFPLAYERQWNDCNYSHLITIPPTNESHGSINSVQNGIMLTWEMHQFFASYELSINPDDNYKIVCFAPDFTEYHIAGSHLDQTFTDNPLRPPDGLLRWHFRQAVLVNMRGAGEPTFEHDFPAGSDVMGEIMRGPKAGERMEFELFSRFNAMGITPVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLK9</accession>
    <name>A0A2T6ZLK9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_258126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLK9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLK9"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24674" checksum="AC10EACDB24938FD" modified="2018-07-18" version="1">MGNSVVASYVATSIIFLGTGILLISVAAVWQKELMSQPTMDSVARYLLLKKAPLSAVIANGVMVVVAFLLSLPTFALPTSRTWLKAHSWLVMACALFTLVLGLMEWISTLKTRANLEEIWGQQTPQIQSMLQQKFNCCGYMNSTTPMYVVDSVCTGDIVAAAEGGCVGPFANFAERWINLLFTALFGIVGMDAVVMLCAAMLIRYRKEQLRYRLIDQKWGMGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM04</accession>
    <name>A0A2T6ZM04_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1194690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000186">
        <property type="protein sequence ID" value="PUU76520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM04"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="414" mass="43641" checksum="3D41105530F5A386" modified="2018-07-18" version="1">MGYADFDLVEVAANTTLMPVTPLSTPSPVRLVLVAPALLASSTHYGPGLPSLMLRSLSPDEQQLYGPLVQLDDTADAIYHLSDVSCSIPIMISPAAASSFASLGFAVSFPPSSQVTWISPIVEAPALVSHAHVYFVSAIEADPSTPTTVVGSDIRILGKSHNELLDVHRIVDLEDKSNTATFGKPIVVSPLSANNAVSTSGGWRRRNRNRSQMNADLSITLLSAPTTHATRVTNAAIAFGLSSVQSATWPVTSDSALCNSGSWIEVVKRCAPHPSPANSIAPALWQTCQDPPSSTPPPLSGSSLDGDASATIEVSNCSHSGEYQKVNCYCRPNPPGEVVIKLNAAVSMNKDVAIAITDKGKDQVWEILKDELEGCIGGSRSPVRDSKLSETTSVSILKRPSSNSAKIVSSSVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMV6</accession>
    <name>A0A2T6ZMV6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMV6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="83" mass="9207" checksum="88F50189B7161236" modified="2018-07-18" version="1">MVILGNVGSSWVGMVVSLLIREDVWDVLKSALDFDHKLVFYHTPRVRGNDRNGHTMIQVLDGGGGRGKGQRYGNLHRGSCRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZND8</accession>
    <name>A0A2T6ZND8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Casein kinase substrate phospho protein PP28-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1087166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU77000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZND8"/>
    <dbReference type="OrthoDB" id="5430994at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015706981" evidence="2">
        <location>
            <begin position="28"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="3">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="259" mass="27878" checksum="077B134C284E50DC" modified="2018-07-18" version="1">MGSLFVAVCSSHLPFFLSFLLIHCANNISLGGKKFSRNLAPLDNDDDGGIPEGMWGVRFFLPPSPTHLTSILTRVQEPRDPKPEIPSSSEEDEDDDEEDADKPELTREERRAAKQARKEAARAKSTATTGPSSLPSSEDEEDEDGEGRVEIAAATKKAKKTVIATANPNAPGSSEAGGSGGGGGGGLTRREREALEAAAAKERYWKLQEAGKTDQAKADLARLAVIRKEREEKARQRKAELEERKAAAEVKAAASGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNS2</accession>
    <name>A0A2T6ZNS2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNS2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNS2"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15465" checksum="76F9D93CAF82D9DC" modified="2018-07-18" version="1">MPSNSGVDARDLHRSQRMEIILSPITATPETQLKEVEEGNKRVRNSLVAKNLSGEAPHALEWTIEMVLRDSDTLMVIYAINQNTVEDGGKIFPDDRIAGKLSSQAAPIGTSLTPINIPHIPRTASPLSNIGDISERGRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPE1</accession>
    <name>A0A2T6ZPE1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1086483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPE1"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="21782" checksum="071D628091956628" modified="2018-07-18" version="1">MEVLLGITGSDFVLLGASNAAMRGVTILKAEDDKTRTLNPHTLMAFSGEAGDTVQFAEYIQANVQLYGMRNNSKWQLSPSAVASFVRRQLAKSLRSRNPYYVNLLIGGFDCTTGKPHLYWLDYLASSAAVPYAAHGYAQYYCLSILDKHHHPNITLEEGKKLMKMCHDELIKRLPVDFKGLTVKAVTKDGVEVVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPG7</accession>
    <name>A0A2T6ZPG7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPG7"/>
    <dbReference type="OrthoDB" id="5314201at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="556" mass="61286" checksum="A1A636CE45FCCB5F" modified="2018-07-18" version="1">MDPTEASRKLLQALSAHEVPLGEEDVLWAFSNAKTAVPVTQWVERYITDETLVSLEELEIYNHLKKTGALSKLQKAHTDLGLVRPRSEEDLEIEIEGLRKSTELLRQHATQLRRQKAALKAMKDRTKADRERKRKLDERRRRKWLSQKEDLQAAIDDLLSILKEEIVDLKQYMKESTVDVEGVNKMLESDDRVLARLERLAGGVIVGGGGDDGKEIVERVTTLVKKLSTLSATALKTRLDRIFLEVAGSHNSANNDPEADELQKDLESLYAEIPSVAEMAAEQEFLQPVLDEVHKGRIKASEGLRLGGTYICDVLHHLQKRHRATAQSLKIELSKQKAISTVLATIAAESVSPLIKPPKAAAPSTPPPAPKSPSSSPSKKLPFRTMPVFTPPRHRRGRSTDFSPDEDEYPELRILALLGISVAPTTTPLFVSPIKSASPTPPAPVVKESQIREHVVQQNSKLRTQEKELATGEAELAEAWNVSRLLEAALRSGNDFPGVGLIGEGLVKGLEEIESKVGAVAGRMEGIAGGLEELKKGGGDLSGRGEKKAFVERWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPJ9</accession>
    <name>A0A2T6ZPJ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stress-activated map kinase interacting protein 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1086404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPJ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPJ9"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="327"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="635"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="748" mass="83106" checksum="9F43657042BE3356" modified="2018-07-18" version="1">MSLLQNQDFVIYRIRTRYLQGMRDGVGERLISVNPASINIPAYKNAGWGAATEIRRTYSPPIPSGTGAEYFTGAPSRSVGLGDGAPPTAIITERRNNDDQADDDTLVGLASHFSNESIDTATDKSEVRRRRRRERQVHREEDDSSDMSDDSDDDDGTQAAQQAIQFDFPKKEVVPPRPRSGSSPLRGPQVLVTSPSKSRTRRLRGGSHGDVDFHKNNQDHLPPADEGLLSSGLVSEIENLHAEITNKLRSSPNSSLPRIEGFGDESADDSDASTSMSSDFNETADSHPAVIGNSLSLPQKRQAATSPAVLHALPPPIRPISQVQPISALTQLLKAKEFEAANPFESYKDFSGKGELRSITLKLLIPYTRSPSLFEANIKQEGNTKKETTVLDAIGFVLYKYIEDKKEPVFTEELSNINKWVFRMVDDGEPDDDFPPLERTQPITSYIVKKGRPGRGFARDTKPEGEFALCEATQAQFLENERVTPNPVSSKKPLAGPPITPSSFTPECATRQTNQIATPGGTSRILRIHLSTIDEFAQSVSVCVTTNTNISEVLDQVCRKKHLEKSKYVLRIAGTPSHAFIPLERTVMSLGEQDQLDLVLRNMPESPTATLRTPKKSKFLQPTATWAPDMLSSRDYLKYTVWRKASMSFMARHERILAIDGEYVHVMPSDQKTLFENSSKTTSIHISTIIGCKTYRKMPSSFKIVVLRPQRETKLKRYDFEAVNEEQAIELVEELRKAMGRFNGGAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPK9</accession>
    <name>A0A2T6ZPK9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centromere/kinetochore Zw10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1065834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPK9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPK9"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048344">
        <property type="entry name" value="Zw10_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20665">
        <property type="entry name" value="Zw10_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 middle" evidence="2">
        <location>
            <begin position="275"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="701"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="851" mass="94220" checksum="9FBD809F1D7E5742" modified="2018-07-18" version="1">MAPSEIKPSQLADAVLSSVLDGSYPDSDDVAGAVLEASALPEIVASLQKARESLYDEVRTASRENGPEVDSWISQARRLHKDIESSKTKADEIIQLVEQEKRLDLELEDSTMQARLLVSEIKFSEALTDILSKLQLIDLTLSQVEHLLDTGELCQAIEILDDVRAALEKLPASDGTIVISLMKEKAKGLRSMLVDKIEDCWKCLLKVNPRKSEISVYRDAAGSGPSTENVIEALKKLDLLNGKIDHLHHQIDTLLVAPRLDLLKGSVPTFSVEGNTLRISGNTNDLNAARMFKDLRQMITFFNRNLPSGITPMFSRTFIPNLTTRLISSSLSSSVPSSLDDLPKFEALLKETRDFESFLHQISWANETELREWTERAPKVWLSKRKETSLDKARQILSHGASAVKVVERAETQKVKVISSTERRKSLGAPMEDVWNNDSGWGDRDTSADTAATAKSLQIDIDDDDASCWGLDEDIDIEDEEQEGDEKPSVPADALTDEDGLDNLDWGEWGEDDPGIEAQESIIASDIGSTKNPTEYQPAKRPPSSHSKDITLRESYAITSIPDAIMDIIVQVVDEAKRLSAMPPSPITPAASGMLSIPSLILAAYRALAPISYSTNISSNMHVYNDCVRIAEQLQSLEVTAELTRPNNSWDTDANLIQSFGKRHYAKEINLQRTILRDSLDGAQGFVGCTNFPRSVDCQTAISSVVARIKEIHMSWSQVLSPSVLFQSIGLLLNTAVTKLINDIEDIPDIPAADSEKICAFFEEIAALESLFPDAPGGAGVSTTGFHCKNWLKFRFLQQILDSRIADILYMFREGHLEGFETEELVDLVKALFADNDNRRKCIDEIRSGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPS8</accession>
    <name>A0A2T6ZPS8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000151">
        <property type="protein sequence ID" value="PUU77485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPS8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPS8"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43423" checksum="924C8E2B6A752F80" modified="2018-07-18" version="1">MSQPTPLPSPPTSPPRSPLSEKAPTTPAAMAEVATATIAVPLLPLRETIISPVGDILIRLLTPTHTLHYKTSASVLITTSKIFSAMLSPTSPFSEARRFNNSPYSSTEPFVLKLHDDDPVALCILLKSLHNHPSVPQSLTFKQLVKMAVVVDKYDCSHATRMYGERWMKAWISKAEIPGYEEWLFVAWVWGVEKIFGKLFGKAVMEVCVQRVGGERKGGGVFGEFVPEAVLKAILNHRAQLLNHIKLVFTALFNRYQPSSTSSQSPLQCAATPPDARCDAITFFSVYRKLSELNLLPWNTIEDLDGFTVNELVGWVLNATPASNVWGGGTKMLSLEKHGKECNPLEKLAAQVKTAIVAGGGSKEREVWEFRVREDDCSWEDIVKEFGIMWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ45</accession>
    <name>A0A2T6ZQ45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ45"/>
    <dbReference type="OrthoDB" id="10491415at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="18353" checksum="F13780DE32943969" modified="2018-07-18" version="1">MSQENKITNVDKFGSSDEEDDDDDISFATAPNEPPPPPPLPLNITRPSSATTATNTMSVGANAGIEIEGEEGGFEEIEGVGDFTGDGDSSDEDDDELISGSVLRRNKPTATHEAERRAVLEEDEGEVEFVSEVRGLSLAGVGDQGKATSEASTSVTTGVEGKSESAAGETQTTETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ53</accession>
    <name>A0A2T6ZQ53_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1128069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ53"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ53"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="123" mass="14010" checksum="089BC32F734BD223" modified="2018-07-18" version="1">MKRKLSHGFSVKALSEQMDIAYNYVDKLIRKINVHASGPKGDEMVKWYNFFTFDLIGDLACREAFGSLNDSMLCLFGVSLLLGNVKAIAWRSVSRWLPVFDKLGVWTSPKSVMKMRIGHTEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQI6</accession>
    <name>A0A2T6ZQI6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQI6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="65" mass="7553" checksum="6F2D04D233E33C64" modified="2018-07-18" version="1">MISLVRPPQPAHPPGRRKEQKRTRKYHYRSALISQVGNSARVRQSNKFHHKGGRFIVKLPAKVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQM5</accession>
    <name>A0A2T6ZQM5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQM5"/>
    <dbReference type="OrthoDB" id="5407383at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="349" mass="40206" checksum="994A4B0B04F92E61" modified="2018-07-18" version="1">MGTLDHSVNPETIYQNKNRANLSPLDIGFERAWANRGNRLKQCCDFAREYNKYKALDDETKAEVDREMSAEENEILEQEREAILADWWRYYPNQFAPERFIHRVYTAGRLSTGSYSFSFIYFYPPSYIRKMSTALLVHHGGFWSPWSTLVLPGPPWSTFLSDEEAGNGLEDSDEVYGEEMIYKEEKEEEETDNDNGGNENDDDYHNDKEQEGSSHSLSQSENSDVDMIGAGEISGSSLGRASRDLDHSHSVSSTGELYSDAVENHFRTATQEIGERLLGRAMTPKDFFTSPEDQQDRIEHIITKRKEDAKEQGIDLEEMDRIDREMDRQALLNLSRQQFPHPVKKKSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQN9</accession>
    <name>A0A2T6ZQN9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1085496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000140">
        <property type="protein sequence ID" value="PUU77800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQN9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17602" checksum="9EDEBF7E3A92A804" modified="2018-07-18" version="1">MPLKHQLAAVAAFFSRRLSTRRLWYLSHKLRSPPTGSVITCNAEMFAKRTAITLSQRLARAPEFWLYCTRVLANKSGLFHKVTTLPPRSWYLGVRVSDRKKVVGCNQQFSDHFLLQAGTVSPYFFVTLTLAISFFAHQTPLFVTGPVSSRVRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQZ9</accession>
    <name>A0A2T6ZQZ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQZ9"/>
    <dbReference type="OrthoDB" id="5419130at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="606" mass="66195" checksum="F34087EBAA3A3412" modified="2018-07-18" version="1">MMDRPNARASAMKRKTEEAPETHGDANKKTKLYNNIRRPSSDTGSDYDDGEEGELTVVATAAPKIEASNAKGSVPKIKVNVSKASSKISKVITESKENGPRVSKANAGKQASNQTKPLKRKPKGTGDDSNEESRSPVVAKKAKVAKILSEALDEELSGSDGEVQKTHGKAKANKDHETPNTQKTKKNPTTAATLITSSTNQVGGILGREVAGRTSRNDLPGPSRTSPLSGGSGSRASHAQISEVDPPRNAFIVTDPNKPRPRGLGRLNFKETPAYTKLMEVATQVKHAARIMTDKLIDAKAASGKDSSTNAAQNTITDACEELEKFMQIYSPQVKFLSVEEHTALVKAAVQCLGDVETAELPDDDFQKVICAFLNGLELGENQATTVGLYPILELYKVGEEAGELSPDVKKLISSINACLIRKSKEAEARLVSPDYIPEDYLTKMQKRVLAMGNVSKPVYDDWDKFLKASAPPKAIQRAQRLTYADQVCAIYQPPLPVLKPVPKKGDWVKNHMISKIISKHRTNKRHETKMNNARKITREHKSYDAKPDDEPIVYSPCRRPLKFDETKEAREILEYDAVGRPLGLNEVEQAGDSIAYGPSGSTLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR46</accession>
    <name>A0A2T6ZR46_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1127534</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000134">
        <property type="protein sequence ID" value="PUU77965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR46"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="587"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="69535" checksum="2C0E3607944B909D" modified="2018-07-18" version="1">MEAKLDAVEGKRVMEKVVLERQLGEIKDWFGRWMKSEMDQKESKVKPGVPLGSDSEWEAECPFTGARKRKVKGLRKWEDKTREEIRILEEKEKGKEKFKYVPRGSGVMGKGDSGVYLLSIAATAVDRAWGELEEAAHFYPPGSKSAGGVNKRAQSGFCRIWDHSSVYHDGLIYVDRTLATKTEGPKGAISLLQPWSLNLTSDFTAEGIDSSSQLARTLGLNPDLPYTMRGALWVSKNGTVYKYGGYYPQEGMWIFSTNVSSIAPRNGEIWELNTKTRNWTKTAQPSGEQFLGARNGGVTSIPTEDAAFFLGGWSSNTTDGRLKDWTHGEQLAHQSMLAWDIKGNEMLNISTSFQAVTLSNLVHVPVAKYGILVSLGGNQFTGSRFNFTSSTSGLKPRDFDSVDIFDFEAGSWSVQATTGDIPSSRHSFCSVVGTAADNSSFNIFMHGGASPNGDDGFSDTYVLSLPSFQWFRVDDTNKVDRYGVTCHLVKNKMIMIGGRGVDQPDPRLNVTMLPGACDPNGIVNIFDVNTLKWDPNFKVSKLDDFKVNGKITGGVGIGGGPTGGAIKIEPEGGWGSAEIRDRFASVVPKPKPSTSTTKTSPSSTSSATVSPTPHNAASGPAAVRGGLLSLGLSVMAVIMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR85</accession>
    <name>A0A2T6ZR85_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1085072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000132">
        <property type="protein sequence ID" value="PUU78005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR85"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="94" mass="10596" checksum="5D1067EFB4A3799A" modified="2018-07-18" version="1">MRKKFPQAKLWVGDQALVCIAVLLKFRLVSLCCSCLAISSLQFKLDLVLLLPGFTHSIACNLGYMHSHSALGRLIFFHHVNSEYHNLRQPVLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR94</accession>
    <name>A0A2T6ZR94_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000132">
        <property type="protein sequence ID" value="PUU78008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR94"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="160" mass="18203" checksum="FA41EF3A53381E7D" modified="2018-07-18" version="1">MTLEKSAKARGLMGRLLDSNHRELYATEWDPAKLWKKLESSASETQSEKDKLYVLLSHLPLQYHPFHTAISNNPNFKDSTYDDICDLLILEHQQLIGDAGYWAKDCPKKAPSSASLANEGRGKVISAWMAATKEEIGRTLDTRLWSYTSYELYAGAFWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRX0</accession>
    <name>A0A2T6ZRX0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable enoyl-CoA hydratase, mitochondrial</fullName>
            <ecNumber evidence="2">4.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1084567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.17" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRX0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRX0"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000019">
        <property type="entry name" value="Enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="30917" checksum="9F5E61CA2A3C5216" modified="2018-07-18" version="1">MFARFIRPTSACLISPIIPRLVRPMSSSSSKSYEHILVSTPRPGVGQITLNRPKVNALNTPLMSELNEALRAFDDSKATGAIVITGSERAFAAGADIKEMQNLTFSEAYGKDFIKLWSDVTQISKPVIAAVNGHALGGGCELAMMADIIYCGPTAVFGQPEIRLGVIPGAGGSQRLVRAIGKAKAMELILTGKAFSAEEAERWGLAARVFETPEKCVEGALETAETIAGYGALAVKAAKEVVNQSYEVGLSEGVKYERRVFHALFSTKDQKTGMTAFINKTKPEWTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRZ5</accession>
    <name>A0A2T6ZRZ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRZ5"/>
    <dbReference type="OrthoDB" id="5497177at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="507" mass="56220" checksum="5AC4212B48A309AA" modified="2018-07-18" version="1">MGNTRRNGLRTEAGKKEIADTLHSRFNHLLKCPGCDSKTTFGAAFNKDAGGTADATGRLYRRFKCRARDICGKTLGVTEFVKLCHKLPPTASSNHHSAQISSDIGIDGPSINQDATTCEQESTIFVSHSSTQPKDYTRPSLIPIPSSSGTSDWNMESELSDNDESTLRKRGMTHLTHEMEILRELLWKSIHDGESMKIKIGQLESKVEKLLTAKRSADSHQPLSRIQSKVIQDNATSTNVESMIANQQPAFLTGDESVSDSGISPIPYSPPLLDTDPKYLDLLRSFRPLSYSSALQSSSKVNRHEIPSKVEPILPQVHNRSIVTTALYVSGIPFMTIKDIKNILASAPINLQRRDICNLSWIDRRIVEILVNTTHAQKIKNRIGKYSEYIVKSDFDPLSPESFHWDGNIQPESQEAILKRNFVMRLSASVGSTTKTSTRQHIIAWANHRGIGPHLQQELNKQGIIFNAENETAFGNDALNDSPSVQSVSRSKQQSSIITTGASKFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS95</accession>
    <name>A0A2T6ZS95_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1084283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS95"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS95"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="264" mass="29280" checksum="0FE0DABB732DBE01" modified="2018-07-18" version="1">MSFTTLPNELILEVAEKLQPHELTCLIRTCRRFSRLLVPTLQKFALSEKYASIALFWAAALGNEQLVRQILTKGHSVPIIRMEHDGKELSMSHLTSNDSEKNELVSFALKQGPNLVLEDGDGRALYWATRHGYIDMISMLLDQGVDIQFKTFDGDTALHAAVVWQNLEATELLIAHGADVDARDGSGRTPLHLATVCNHVAIWETLADHGADLYAVDGYGKTISDKVLPRNGYCEEVANSFAWYSTYAKPSRPIVTSCHETGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT36</accession>
    <name>A0A2T6ZT36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1141712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000111">
        <property type="protein sequence ID" value="PUU78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT36"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="167" mass="18929" checksum="9EA4B872A5BCDDC8" modified="2018-07-18" version="1">MIKLKLGVQTGSRLVPGAISTRFPCQQFQPSGSPGGSHPWTYSQLLNPEGPYVTIDHMEQHFQVLDENTTRIQTQLRHLENGQSNLESGLDKLDEKLETMFLTNDSKLKERFHTSDKKWDKMFEKRDGKMDTCIYLILGAILLKGGLEYWNDWKDDGADPNGGSAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT78</accession>
    <name>A0A2T6ZT78_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_40887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT78"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="190" mass="21696" checksum="5CEDEA4B23A2E730" modified="2018-07-18" version="1">MAHKCQRKVVTINSAPQIPTAHISQNLTIHIQQLGHRSSNSEKGGGDDSQVPERSNRQFRAPRYPWLIFLKSLDFSQVDRYLSIYISPRWPFFFLKFVLLDLSLRSFYLPLNQRLAFRYFYLYGILACLPWIIAGDATAWCALLATTTRLADIPYIIVQLGNLPANLPHPDTPSSRTITLCHPGIRLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTH7</accession>
    <name>A0A2T6ZTH7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTH7"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="12270" checksum="E7A1729200BC66A9" modified="2018-07-18" version="1">MQRFDQVSRAMPWSGHALVTEDSRVPSAREEDSWHRAAKYQKAAELLTLSRVTRIDIRRKDENGGKFDVNPKPNLTGAGFPDCDEKIVFGLWLLKDMDGVPEVRAEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTI3</accession>
    <name>A0A2T6ZTI3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTI3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="22774" checksum="CC4897FDAE9BE8A8" modified="2018-07-18" version="1">MAHWEKDTGDDRSTEGTKNGEIFGSIAKEPPSPPLEKSQNRREDGHDQDAIRESPEASQIDEGGEQAIKQDTTAGTRWRGGTQLAGKAEEVATETTYGEKIAAYAEPTLAQIHDQVLDAVSGQMFLETSCGPGEVTAFIGNIITTIALQARAMAILARDYNITILARMEPVGVSQAQLQFQRRDFTPRCVDAVRRVGGIVEVWKRGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTI9</accession>
    <name>A0A2T6ZTI9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTI9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTI9"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="167" mass="18447" checksum="E741D4705849DEA7" modified="2018-07-18" version="1">MLHARDDLVNIYSVVIVEARLGGDEGTMTLVPDGQGNFMALPIVQRFDQVSGEMPWSGHVSVTKNSWVLSAREEDSCHLAAKNEYQKAADLLKLTSRCDDQDSLWAMAAKGFGLYPTFVRKCIETARHLLEARTIEALGTVVRSLDNFTVWEKWSGNGKDGSLGIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTY8</accession>
    <name>A0A2T6ZTY8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatidylserine decarboxylase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1114700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000103">
        <property type="protein sequence ID" value="PUU78943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTY8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTY8"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF13">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="393" mass="44396" checksum="0A1365DDFC993063" modified="2018-07-18" version="1">MPNREQSFYHTEENLDNIDNLTDYLNDINEFLFWKPTENERGDKVYNKICLFYWFLEQRTTLVLQSEVLPNQADRPLTILSNWMVDYANSLGAFYDTEASINAETIETFYNSPPYKMDQYERPPGDWKTFNEFFARHVKAGLRPPDDPDNPEVIVSGADSVFDGKWSVDDENKVFFVKGVPWNIKDLLKGSDYADRFKGGTFMHAFLNTTDYHRQHAPVPGTIVEAKVIQGATYLEVVLVTDPDSVKDGLQEPRNMFAMRRCMTKGMTDANIIRHEYRGISGHKLTSEPARGLNAPDTPGYQFLQARGCIIIDSPIGLVAMLPVGMAQVSSVRLSVNKGDQVKKGQEVSYFQFGGSDYILVFEKGSGVDITANEGTHYLTGQQIGTGKVPTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU64</accession>
    <name>A0A2T6ZU64_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1140514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU64"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU64"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9810" checksum="F1C00D207F833FAD" modified="2018-07-18" version="1">MEYLEEGDLTKHIGAPLLQETVRNISKQILEGLKVMHQQGIAHRDLKPANIFVVSVSRVGETRRFRGLKAHPGPINHDPSHPSVNSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUR1</accession>
    <name>A0A2T6ZUR1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_980445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUR1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUR1"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="783" mass="88921" checksum="CEBE85C6DF801010" modified="2018-07-18" version="1">MARKNSRKSPSVASGSRGSGTGAVSQALRLRRWIDIQLKDVLEERARGNWTEEDEREWRRTKPYECETCNERSSTRYNNNRHKLNKHSTKKVLNCTFPGCKLVFTRPDNLAKHQKKHHSTSQNDPEDEPRDDVEKLASQFWRRFPIADDLPKKPVDGLRIYYTPGKLPFLPPEVISHYADYYFAPTAFHPFLPLLHKPTFQPTTVLASFLRSVCALGGRYDPTNQTLREQLWEAGLRVMERWIERGPDDGGDQEPPPSMSPPPLVKTESSQAMVHPHPPSSSAGDGDRQSVKYADRSQREGTLCVLQGLLLFAFYGLFSEEKEKHKKGRVLLARAIARDYEYFNPAPGHIPQELPADQQWKTFVDRESRKRVAFTIYLVDCYASFTFETPRLLRYTELRNLPLPCDAQLFEAPTAQAWHQKYYTMRIHGSRMVPPPLFLKTLRILLNGNGHHELLDAGGLGSNFSALILATAIQMEILDLTRKVADDIDAQYETGILAPEEGAIWEGVDVFAPESQEGLEKLRMGLTTLGLISGIGNLFTPYTEHIPVFPPVTTYASTSPTLLASALQGCEKAFYILMHLALIQLVIPDRMVLHKKDVPMDLYTALASTVHGAKARVAANSPATLQHFMLVLDQSHVLSHLLSLLRVLLAPQSAYDENARNTEFPIVTVLIFKALMVVWEIIVRVENQPSPQEEMYLWHQYGLDGNPNQVFAQDIVVKPIEAFRYELLGLLTQWEARNEETEGLESLEWRYLRWMKAVFIEMEQWGVGGGVVQALDYGLYGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUZ5</accession>
    <name>A0A2T6ZUZ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein PET191-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1082179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUZ5"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="11615" checksum="3EDF545732E1C5CF" modified="2018-07-18" version="1">MPSSCKDIRAALAQCLENSDCVMVHRNKPADCLRSPLVESLPNRCQRLKKGYGECKRGMVDMRKRFRGNYPVALSVENEGGGGSRQLYGGGSALGGPPSGTKAEGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWA0</accession>
    <name>A0A2T6ZWA0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1080969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWA0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWA0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="509" mass="57851" checksum="B2586BF54F1F2388" modified="2018-07-18" version="1">MSKLSEILRGQSYGVVFTPVNTVLAITAFFFLYYLKQRFFGPLRHLPGPWWSHYTQFPDTLHTFSGNRSLYIHSLHEKYGDTLRLGPNTVGVTGQEGVKTIFGGGSKRPFHKEPVITEMLNFGRTFEETMAGTADPVSSSKRRMMYGNAYSRGSVLNMQDIYQKCFMNFIARIEESRKNSQDGIIGVTPYFRAMAYDVLTEAAFGGLCKGTEYGTDAVGIMDNVMNANLFQWYFGTFIYNLTMKIPWKKLDWIRSKEEYLQATQEVVSVYQSNVKAHPDRVRKDLLGNLILNNLDPKKLYHEAYGNIWAGTDTTTNTLGVLMLAIVRHPRIYKNLVAELDRAFPPGEYVPFAPMELQKLETECPYLTCCIKECLRRYPLIPGPSPRIVPKEGTNINGWFVPGNATIFAQTYTTNHNAKIFPNPKMYIPERWQAGKETAEMKAMMTSFGSGPRICAGENLAMMELHCATALLFRNYVVSIPDGYDNDHVEFWITTPKGGSIFLRIEPREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWN5</accession>
    <name>A0A2T6ZWN5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWN5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="68" mass="6705" checksum="BBC1B0394C3B452A" modified="2018-07-18" version="1">MRSRSSTVKGSGTVRTKEFGSLGVVLNHGNGVVAAVVAAAAVVVAVAVVVLFALVVAHICSSGTQGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWY7</accession>
    <name>A0A2T6ZWY7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartic peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1107379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWY7"/>
    <dbReference type="OrthoDB" id="5357409at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015414224" description="Aspartic peptidase domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="85628" checksum="57A856A19A1A6AB0" modified="2018-07-18" version="1" fragment="single">MAIQAFTILLLLTQWALPTHSQEVAELISFEFSTTLSLALGSPPQTLRLLPTFYTSPSTTLLVPTGAMCLSGSHPPEGDWNPITEPREGSLVETSSGDDESVLGSGGQIVRWRASSDVKSLNLTLRRGRGESVRNVSLIETDISNDGEYPWHANSTYTKANLTPGSDYSLMLWTENPPRQSTSGFFTLGPTNATSNSTTTPPVKSAEEYAACIKALGKNGYYNETLDADFVAGVTLGEGIGITSASWKTTKPGDEFSLSGLPVSVIHESDSGYGMVGLSALQRARNSRVPEMDVVSLYLGSKGVNGSAVMGGFDEGLIDHGQKAVFSKANVNSEGFAVAVTSVKYVAEGGGGSKETEVYKSTKGGTQMALSYNSFQIRLPPEMLTPLLPLLGNPSYDKGVDGYVYTGTPPTDYTLRITLWNGTSTVIVSIPATSLITTDESTDNPLTSHRESGQTYLRIAPTSSTDGPSLGRPFLEHVYLINAPPTINKFHISAVPSPPRKSNLTPASRTSIAIFLTDTTTNSSSRDSPALGPMIGGILGGVLFLVLAVIAYIALQRRRTRSRSSGSRLTVRFAPSSYSPPTFSEEGEKSRTRSLATSTNLSAFEKEVGVFAMPPNHPRQQPRRSSSAPLHRPHTGIPGQTRQTVSQQSTRRKRESENSTVARVLSSSPSPTIEIYEVSEGVTAASTATMGKFYTGAGIVGTPPYTSTPSSASSASARVVAPAKAHVRTASLGRMVTPVHVELSPGPSRRSSVRTPPLKRHSQLGQDGRSSGETDESSVFGLGAVAKDGEFLRKEEAKGGYLQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX70</accession>
    <name>A0A2T6ZX70_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1107320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX70"/>
    <dbReference type="OrthoDB" id="10519262at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="197" mass="21224" checksum="6919A3C7EF073DC2" modified="2018-07-18" version="1">MGPAQPNWALAIQRPDRGQDLASVSRGPRLVPWGPSITPLVKEGDNILSLVDYDQHGNRLRLPVGLGNLPLDLDKDGWHSVLGTWNDTTNNPQTANEAVQVNPENDIAIPLASLSPPRNARPLSQAYHATIISAQATVALILAPKAELPARPRIVPGLEFSRQSKHSTDTTAQSTTMTVWIVQLRGVCVLELGGSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXH5</accession>
    <name>A0A2T6ZXH5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1173104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXH5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXH5"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016441">
        <property type="entry name" value="Tti1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005250">
        <property type="entry name" value="UCP005250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="740"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114540" checksum="FAAC8DE0057CDA62" modified="2018-07-18" version="1">MSEETQRQVFKELKPHCIKVSETILKPTPDPRGLSTSLTQLLQTLTSTSGRHGEVFHRALGDYVFYPLSHIFRQHQTVNDGALEKALGCVRILLNTCWRLNMPAEQAKQMLIMITFVIVGTPGAPVNANRSEETKIEGMKCLLALFECVKRAEKGVLGDVESLPALGHSVTAVLEVAISTTSPQLQMVSLECLEALLFSCVTDSDIFASFYPGVVSGLAKVIGLGPTTKRPYEVLARCVKVLNHVICEVLGDANVGESEDLKVHRTTSWLTATATQTKSALDNILRLRGHSHSHVRKSVFELCRDLLENCAKSLAEALTAIIETMIVLAGDEDDSLRSISENTLRVAAMSERVKETIQSCVHGWAISLPRVMAGSEEIMKTRLISRISTGFKILTELGMGSEILQETLAINIRDSLFTAYTGATGKQEAIQAVEEPLPFDALVSRNKAIGILSVYPDVVLGHRSQRDTIGSVKKLLSLLGRSSENALRLAQRHIREGSRVNAPTKDRSTSLWVAVELLRGSLANSDEMDIFLDLDFSPSGPLQQHVTEELFAVSLSVLSDATELGADEEADLMSPTLQCLALEAISLTAQAQKESFREELVDALYPIVHLLGSPSRAVQSHAIVTLNNVSRSCRYPSAKELILENVDYMVNAVALKLNTFDLSPQAPVVLGMMLRLAGPSLIPYLDDIVVSIFAALDAFHGYEALCEALLGVLAQVVEESRKGGDLLAITANNDDSSSSSRPQSKRRKLLTGEDLIQEISSNLRKEQETKKKAAQEETDMAAGKFPERPWGKGKENGKNEDPTIMGEGKDEESEDQPAPPPPGTQVAGPTKTYDLVQRITRLSQHYLTHPSYPLRLRLLHLISTASPLLSKSEDAFLPLVNDIWPAVLNRLFEDELHITISAAEAITTLARECGEFISSRIVDAWPGIKRVFVNCLRRWEKERASKTGDMGTYSPGYKVWDALCEMVAAVVEFCRVSDEIVDDVCKIVGGERLLQRTDLRNALEGANAEAVWLEIESWKARSGVGGKWTLPALEGVKFYEVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXJ0</accession>
    <name>A0A2T6ZXJ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1173202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXJ0"/>
    <dbReference type="OrthoDB" id="5355583at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="302" mass="34734" checksum="43A343E048820FD5" modified="2018-07-18" version="1">MANWIRSFLCLSTNRISSVSRLNTKRIHSFRTFSSTMEHFYAKKKLLESSTNLKSTKRNKKWETSYSKMSQTAALERLGLDMQKFDQSSIPVQRMLSEAKCEIEGIRANTVDAMKEKVYARILEYIQIEGYPSEASIWFKEVNVNDLVLYILGPILFDFQKETGREIKLRREMELVSSDSQTGGFEEFVIVDTISTTETSFLLIIESKRTTLGHGIRQCLLAMYDMFSYNQGGKAYGFVTTGELWRMIQYDGTKFQMTETFHCLFGEIGQEKGRWMEEFSVVVECILAALQSGGIAKKDKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYR4</accession>
    <name>A0A2T6ZYR4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_974322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYR4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYR4"/>
    <dbReference type="OrthoDB" id="4232400at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="59" mass="6760" checksum="DBB6733CE2F54165" modified="2018-07-18" version="1">MPDSKYGTVKDGWGNRTNFQASYGLNTTPEDLEEGNEILELMQKNHTGRRPHQIIERGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ71</accession>
    <name>A0A2T6ZZ71_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1063221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ71"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11474" checksum="B109B727F7E10DE0" modified="2018-07-18" version="1">MKLSATQVILNLTAMTALMFTLAIAMPSTTSSKRKDGTEKGTLHQCSNKEHGFIWFKETPFNAAVAIYVHLRSEPSQEDREANTKEVYESNTDSTYKGTSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Q2</accession>
    <name>A0A2T7A0Q2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_972058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Q2"/>
    <dbReference type="OrthoDB" id="5364171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="247" mass="28359" checksum="421FBB588F03D84D" modified="2018-07-18" version="1">MSGVYYVYMKYVRETDTLRADYGRHLLTFRSRWDADELFRGLQALKTAAGASRFTKLQRVTSQFWCYDTVEGDPWWTIVYVQRENALPAFNYKFMSVILADAAAGRDWPVLANPTIGPDWVNGKTFYIRNHRQPNLYWYYDDSLIVISTSRRTKFLIKDSTYDEERVLIRSDKVTIEPTGSLGTSIGVYVTKNGDGNKLITSTTEQVWDFADLFDSVGVTWDDQSGFTSGTQFATSLPDLGDEWELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A175</accession>
    <name>A0A2T7A175_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1062621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A175"/>
    <dbReference type="STRING" id="42251.A0A2T7A175"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="60654" checksum="B013CEFD05F49ED7" modified="2018-07-18" version="1">MGIFMRLIDYAEDKKLYSYSLFSATLALLFLGLFLFLKKEWSIHSSTRFPIAGIESPGYFGLVKARDRWVSDALHIVKNGYHKYRGRNFVVTTHSFDKIVLTYDQIKELSNAPDDMVGAQDSGTETMLGSYTGLDRFLEHNYIQGVARIKLTQNLGSIKDAIIEEARFALDAELPECTTDEWKSVQIFTTVLRTVTRTSSRVFVGLPLCRNEDWLTVAMGYTGDVFRTVDKLTSIPKPIRPFYAWMFNSTKLIQSHRKRAETLLGPAIQRRLEEKRLAEKNGAIYEKPDDMLQWLEDLVQPHHKTTESLSELQLLASLASIHSTCNTFLNALFDLAAHQECVQPIREEIEAVISANNGVIDREALRKMRKTDSFFKESMRKNPHLFGFNRKILKSLTLSDGTRLPKGALVAAPSGILSTDPDFIENPEAFDGFRWYKKSLEAEGRAARDASWTTTSAWDLGFGHGKHACPGRYFVTEEMKIILTFIILQYDFKYPEGQSRPASLSHAEFFYPDTTRKLLFKKLPGPKKFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1W0</accession>
    <name>A0A2T7A1W0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1062433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1W0"/>
    <dbReference type="STRING" id="42251.A0A2T7A1W0"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000037">
        <property type="entry name" value="Rad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="109"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="538"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="81927" checksum="AD2363CB412B6B09" modified="2018-07-18" version="1">MGIVGLYQELGPGPRVSLAKLSADHYISTGRRLRLAVDASIWAFQVQAGKGGNNPALRTLYYRLIRLLHLNITPLFIFDGPNRPVFKRNHKTNTVMTPTLTRSTKALLKLFGFPYHEAPGEAEAECANLQTHGIVDAVLSEDVDTLMFGCEVTFRNWSGEGGKSKAPTHVSVYERESVEAMSGLTPEGMVLIALMRGGDYSPEGVPRCGIKIAADAARAGFGELLCALDVQDKEGLAAWRRRLQRELETNESGYFKRKNKTIRIPEGFPDITILGHYKKPVVSSKEKVERLRNSICWSGEINFSGLRESARWAFEWRGKIGAAKFIRCLAPAVMSWNLCTSTEGVRELVSGFHGRREHFSTGECRELRISFVPGNVVKVDMDAEADDDVEVQPDDDEEFAQEGEDGSRKARDYDPYTLERMWVLEVFARQGVPEMVEEYENPKPKAKKTAAATTKKSRLARSKDKSVEAVHTMPEYLTVSKPGKQRPTPSKHPQEPRSSSSARRTQREVSVSLSSLTSHLSALQILEDDAFTHPAPSPTSVPTSKGNPCRQPLTSNPSTQNHHPLPSERETSQEQENIWTAPAWPCETIGLSPPRGRGHPALGAYGAAVSPQAVSPAVTAPAPEEERVTVSIPSSPEVETVRRRRVDQRRSSTDKKKNTSRGKTPVCILDISDSESEGEVPDRRASPPLSLSGGRNEKKAVASGRANKKAVLRTSVEGSWKFADGEALASGGGGWVDVEVMDLTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1W7</accession>
    <name>A0A2T7A1W7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1164783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1W7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="19682" checksum="DD6142DAA75422D3" modified="2018-07-18" version="1">MKSSESVKNIEGEGAMYSSTASYTTYRACGTGVLTMRQGPSSPIAPIKDSTPPGALPTQFHHVRYPDAYYANMILVNSLIGYTTLILIWSRTRGKGVPAFESMQHTVAVFNALSSSLSIIHPMGDKATQSHLKIVPGASNLRFLEPDHPWVKGDAGSILKQRESGEVEKDLRNIGWGLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1X9</accession>
    <name>A0A2T7A1X9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="12" type="ORF">B9Z19DRAFT_971002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1X9"/>
    <dbReference type="STRING" id="42251.A0A2T7A1X9"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="11"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="208"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="387"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="428"/>
            <end position="431"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="529"/>
            <end position="530"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="535"/>
            <end position="539"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU81750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="610" mass="69866" checksum="F6D58F95AAC698DA" modified="2018-07-18" version="1">MADSLLVSPRILILYASELGTAADLAKEVTHTLLRRRLNVRCIEANELEPFTSLPTYNTIIFLASTTGQGEIPTNGKDFWRKFLVKRIPRDWLKDVEFTTFGCGDSTYLKYNAAVRKIHSRFLQLGAAQVVARGEGDEQHSEGIDGSFFPWLETLVRTLSEKYPLPDGLEPIPADHLLPPEHFLMLTSHRKVTYPLRDIMKDLHAPRPASRTFQVAKNERVTAESHWQDVRHITIRVPGSSTRWAPGDTVTLLPKNFPQDVEEFLACQGLTDIADHPLAFVRTPDPVIESPLPGRLIQPLTLRTVLIHYLDINAIPRRAFFGMIANFTSDQFHKERILEFTKPEYLDELYDYTTRPRRSILEVLQEFSSVRIPINRLADVIPILRPRAFSVASSNTGHSPGPFDERNNLEILVAIVKYKTIIKKTRQGVCTRWLASLKEGDPISVVFQHGTLVPHFSTELYNKPAVMIAPGTGVAPMRALLWERVFNEGHYLKNTLIFGCRGKDTDFFFREDWARLVRRDFLRLNTAFSRDQPAKRYVQHIILEQAEHLWDRIYKQGAVVYVCGSSGNMPIAVREALVKVFQEKGEWEKEVAIAYLAHMEKEGRFRQETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2F5</accession>
    <name>A0A2T7A2F5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2F5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17359" checksum="C47E42D9FABB54D4" modified="2018-07-18" version="1">MRLVLHCLRSLTVRPSGLYEKWGTARPGCHPLKREERELGPSTSSVGNLLNPPLGYEAGLEKNGKHCLITNSSFVLFLLCFLCSEYTVRVFLLLPAGTRSNYLLYGGVLSLGWMCGWFHTRGTRGGLFFPRPTGEVFDGHTLGSTGARICLCSDTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2P8</accession>
    <name>A0A2T7A2P8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1075946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2P8"/>
    <dbReference type="STRING" id="42251.A0A2T7A2P8"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="267"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="646"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1044" mass="117854" checksum="F924EE43D8CDA1A0" modified="2018-07-18" version="1">MSTTPSEDDDLDLDYVPRPLNPAGSSINTTATATAPIEASTDESDDSLNNTASRHTPPSFTNTTQEAEENETSLKETVRTAKHQSGTGERILMTEDEDDDAYEEFKRKKDEGGKQRGRKKRKVGSSWRETGGKKRVKSEGGDKKPPNQRLWKTASDSSDQDVGVDVGVEMGLPAYLKARKDAVEAAKAAIEDTDTPPDALRFPPDYGDVYFSDDERLGELASKPNFKNIPPCAPYKDIPLEDSLGIIPCSIAQYLRNYQVEGVAFLHKNFVFQEGCILGDDMGLGKTVQVIAFLTAAFGKTGDERDRKRMRKIRRGGGGKRWFPKVIVVCPGSLISNWQREFDVWGWWNVYVYHGSKERKESALEAARAGRCEVLITTYGTYKKACGDINMVEWDCVIADECHQIKDRRTEVTKAMNEINALCRIGLTGTAIQNNYEELWTLLNWCRPGGIGTLTEWNRAIATPLKVGQSHDATLRQIGNARKIAKRLVNNLLGKMFLRRLKTLIAHQLPKKSDKVVFCSLTEVQRKAYQGFLESEMVQNIKYSGQVCDCGKLNKNGEPAKRGSCCYVTDSKGRKWREMVFPCIQQIQKLSNHLANWIPQNEDNQETREKKRELLETCLPDDYERIINREMLTNFMDPEMCGKWIVLQKLLRFWHQNDDKVLIFSYSLQLLRILHKLFQSTEYNVCYFDGSMSLDERTNVVSEFNSDPSRFVFLISTRAGGVGLNITAANKVVIFDPNWNPSYDLQAQDRAYRIGQTRDVEVFRLILAGTIEEIVYARQIYKQQQANIGYGASEERRYFSGVQGDKTNQGELFGLRNLFTFQDNTILKEIVNKTNVAESRAGVQVAGMEANNEEADVELDDDYEGENAISQLAAIAKGEQAIKKKKAHNPVAAILAEAGISYTHENSEVIGTSKIEARISKRAVETTNDAGGGDLVAFASGSTIYKFHPPMHVMKRQFCTMAKMFRFDDVREFALVVEGWTQKQRRDALDKFYKMRRDSIVRGEGGVGLEDFPDEKRVDVKTEDKVVDKEIKVEEGDDEEGDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2U4</accession>
    <name>A0A2T7A2U4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_969446</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2U4"/>
    <dbReference type="STRING" id="42251.A0A2T7A2U4"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="287" mass="32764" checksum="719834636F1C4FD5" modified="2018-07-18" version="1">MRGKRSKAYRKLMSQYNISFGFREPYQVLLDAEIVKDSDRFKMDLVGGLERTLQGQVKPMITQCSIRHLYALTESEFPERDQIIALAKRFERRRCNHHELEQPLSEKECLEAVIIHDGENKHRYCVATQGGDIRAMLRAVPGVPLIYINRSVMIMEPMAPISAMKRERGERQKFRAGIIDTRPKAGAKRKRLPEKEDEGDGEKKKKRKGPKGPNPLSVKKKATPKPVTLKSTAAPKPEVSTLKSEASKPTRSGESTTNGADNEEKKKRKRRHKNAKIDRAPERLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A364</accession>
    <name>A0A2T7A364_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1075418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A364"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10690" checksum="0963D36036341665" modified="2018-07-18" version="1">MVCITTAAVIRYPHLPARTGLARIKYIELLTSHRSPTCLSYYNSNNNKQGKKGLQDSLQLSQNGAKKDKNCISSGWLIVVLPRWVSSQIEVPKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Y2</accession>
    <name>A0A2T7A3Y2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1017659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Y2"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Y2"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="594" mass="68410" checksum="C89DC4C300F3A876" modified="2018-07-18" version="1">MASFNLPNRPPAPASFGTPVRPPPLAPGWTEHKAPTGHTYYYNGATKTSTYTRPIAPSIAPPFASGPGPFPVFDGAPAPYAGGFPAQQVPQQPFPKQFPPQQFPPYQHNYGRGGGGGGGGRGGRFDRQNRNPRHPQRKRQEKPDRPRSKREIPGMRPWVLVTTKRGRKFVHNTETKASLWKAPDDVQAAIDTMPPEEGKSGELKKGKGKEERRRAVSAAAAAVKTEEGGSEAPDRENARLREQEEDEEEEDEEEGEDEEDEGEEEMEEYAQKKLKTLEQGPLEFTEDDVAWQLEAMAQEYGLDEEDFDEGEEMTDEDNIYLFKEMLAEYKVNPYSTWDKEMPRIVEDSRYVLINTTRARKEVFTNWCRERIAELRIEKEKTKKQDPRIPFWEFLKGNASAKLYWPEFKRKWKKSSEMKDSKVPDKDKEKMYREYISHMKISEPLRENDLKKLLKSTTLPRHTTLETLPESILVDVRYVTAPDNARDKVIQDYLTTLPEDPEEEKERKERERRDQALRDRERAVKKEQWKLRGEEQRAKEMLREEEAMIERAKVVGKRGLLGHIIKKEDTAESEKGDKEGTPKPDEPRREASAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4W1</accession>
    <name>A0A2T7A4W1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1120171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4W1"/>
    <dbReference type="OrthoDB" id="5385208at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="11121" checksum="0C3D08610B914CD5" modified="2018-07-18" version="1">MAEPQANEFRTGDIITITFAIITAIVGLFQLFPRWRFWEPTQPILPITHQELRPVLVVNCIGQLNFQSLEHEADLERDPPPTPRVRKNIGRRFTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4X8</accession>
    <name>A0A2T7A4X8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4X8"/>
    <dbReference type="STRING" id="42251.A0A2T7A4X8"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42575" checksum="109344042CFFF257" modified="2018-07-18" version="1">MSNERHRLIVGVDFGTTYSGLAYIHTTEPDYKNIEVIDSWPGRGNTNHAKVPTEISYSDKGATWGYDIPPNGIRYGFFKLLLDVNAAETQYDDPRLATSNPQSMESSYANIPLPPGKTAAETTTDYLKLLYTHLMKILHQRFIRTLYNTPIQFVLTTPAIWSHEAQSSTCQAAKDAGFTSRAGDTLTMVSEPEAAASYCLKEIYHEHSNSGSPLEPGERIVICDAGGGTVDLITYTIKKSSLMRSFDTAKKEFGTTTRTDFWRIPVGYVRDDPKNGIEDAELRLAVADMKGLFDPIVKQVISLLEQQVRDSNKLDSSNKVSTIFLVGGFGESAYLYKEVQTWVRRQSYHIRVINPNFSWSAVVRGAVFHGVQGIVHTRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5P5</accession>
    <name>A0A2T7A5P5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_237667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5P5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19282" checksum="9A6E895A65F5BB5C" modified="2018-07-18" version="1">MECGVNGGKAAPLPSALCPQLLRSRACWLVPLAKRLAEKKCTCELEIREGNATRPELGLLVPAAMELELESLRTPPPLLTTLTRRTHRGLSQLLCCFLPTRTPNTRMGECTGIVLVGRIPYWYGSRRTKPPTKFVGCGGLFAHSPVHFQFQCLGSDCLREEDTVCKRANGKTMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6S0</accession>
    <name>A0A2T7A6S0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6S0"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="266" mass="29239" checksum="AC40D8F2924DAC7B" modified="2018-07-18" version="1">MSAPSCTYGSTNSSTFGSPPQTKLVPAEARYYLEEGLEGVERHEYRSVRSFVTTITKHMDEFQFGGAAQYAVYSPVSDEEFTKIDNARDRHLKGLDQVPLSHQRKGVDCQIHSGRKASLMDSGKELGDIGKTRFSGLGSQKEADTSVLGTLKGGCEMVVRELKGRGGNCYSCCYFKGTRSLHVEIWELVDMPNLDITRANPDPFITGVVTKTGEGGIVGEVVTGAPLKISFKKTMLRDPDEALGENDFVIDVQDFKEVAQMAWDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6U2</accession>
    <name>A0A2T7A6U2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl transferase/acyl hydrolase/lysophospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_83513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6U2"/>
    <dbReference type="STRING" id="42251.A0A2T7A6U2"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="12"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="64"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="630" mass="69105" checksum="FD8C3A1392ECEA20" modified="2018-07-18" version="1">MAQSNLLPLRILSLDGGGVRGLSSLMILQDIMNTISQQEKSSNIRPKNDNTPLKPCEYFDIIGGTSTGGIIAILLSRLRLDVPTCIDIYTRLAEEIFSKDRSIKIFGTPLRFSGARFSGAVLEKAIKRVLVENGFDPEEKMFDETLSLREKEIRRRVDTDQLAKLEVTHSGGVKDVIEKETWRTSTNSNPLLTPGPDSTPNPDTPRTQPGEPGCHGIVVAVYKHAVGVPKLFHTNDPMDRNTKIWQALRATSAAPTFFDEITFGTPKITYIDGGLGYNSPCAEIDFEAKTRWPGREIGVIVSIGTGLQTIPAIRRGVRWLPFGLQRELSLAGALVAMATSTERVDNEVQRMYRDARTEYYRWDVDSGLGEISLEQWMKEDEMGSVTRRYLDDPDQVIRKQKLAGTMVGISAERRVVECSAGRFAITPTLTGENAASWSLENIFLPGVPGNSHAGPIPVLEDLDHDGTRAESQILSCNRALTSSIDLRTLISGVPTGRYKIRYILRSSMPTSSSSPLLPPDNLVLSAGKPYDAKTFTNRFVDSYISPDVVPVLLYPDAVRVRVTAQQWATEDEEDSNGWFEVSGDAEVEVGIGGCVGVVVGCLERGGRDGELDDGQICGGWGFGGVRLVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7M4</accession>
    <name>A0A2T7A7M4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="4">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1118876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7M4"/>
    <dbReference type="STRING" id="42251.A0A2T7A7M4"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF3">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="7">
        <location>
            <begin position="187"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="331" mass="37745" checksum="1B0E4ED86963D53A" modified="2018-07-18" version="1">MAPATTLPASWFQSTPLYQLERRAIFLNAWHFVGPITRFVNRGEKVYYEIAQVKFYVVNRSPEDTGWGANGIEVHRDNDDGSIHVHFTSSGLVFITLSSDSLAFEEFFPDLEPLLSRVDFTKLKYRRSISYEGCFNWKTMIDGYQECLHCQYAHPSFSKLYPPTFYSIQNHGNFCRHIADPKKPEDGLFLYFFPICTLNVYGGGMSSFRTCPTPDPTISRMEFDYYYNGEDEAFEEYFKFVRQVALEDYELCVAAQQNLQRGVYVEGVLNPEKESGVIYYQQLVRNLVLERYKAEKAEAEEEAVKGSISHVSAINQAPSGLSAPTTVGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Q9</accession>
    <name>A0A2T7A7Q9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TLC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1071625</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Q9"/>
    <dbReference type="STRING" id="42251.A0A2T7A7Q9"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="70"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="365" mass="41500" checksum="ADEF24CAEA9F439C" modified="2018-07-18" version="1">MASSVLFAPCPPALTELVKPYATKIGLHSLPLHIHQVIAAFVVYHFIFAVISPIFSSIALPKTYRNFDKRTKVNWNVHVVSFIQSTFICVLAIWAACNDPQRDAWSKDEAAMLKRTFEYNHIQGAVQAYAEGYFIWDLFMSAWHLDIFGLGFLAHAASAVMVFSLGFRPFVNYWASVFVLFEISSPFLNIHWFCDKTGMTGSLTQLINGFFLLTSFFCCRLIWGTWNAALVFIDLHSIYNNPPSVLRPSDDNLIHPDHLETDEIVAHPFAGKSLPFWLIMVYLGSNTILNLLNYYWFGRMIQTVSARFTKDKPAKKGKKEKKEKEEAIEVDANGKIWVEGTDVNVGTTVEVVKEKLKKRTVTRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7U3</accession>
    <name>A0A2T7A7U3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptide hydrolase</fullName>
            <ecNumber evidence="10">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_962336</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28A subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7U3"/>
    <dbReference type="STRING" id="42251.A0A2T7A7U3"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03876">
        <property type="entry name" value="M28_SGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000054">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041756">
        <property type="entry name" value="M28_SGAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015374686" description="Peptide hydrolase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="12">
        <location>
            <begin position="131"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="13">
        <location>
            <begin position="207"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="461" mass="49128" checksum="17DCF0CFB7770A7B" modified="2018-07-18" version="1">MKLPTGIFLVSSLVGAAVATPLAPVPYNISLVESNKLRRVLHRKALYEHAKEFQSFADSTSVRNRVAGSIGHNLTVDYIYDTLVATGYYNVEKQPFTYVFSEGNTSFSALSTKYASEYMTYSPSTGGSTLTAQLVKVANVGCDQSDYPELTGKIALISRGICQFGPYVPVASISGANGTALVAAIEAGPVQGSLLVNSTTEVRHTNNVLATTKGGDQNNIVMSGGHTDSVAAGPGINDNGSGSIGNLEIALQLTKWLVKNAVRFGFWSAEEFGLIGSRYYVENLPEAERAKVALYLNLDMIASPNFGYFVYDGDGSTFNITGPPGSGAIEHLLQDYFKEVGLPTLPSNSDGRSDYAPFMEAGIPIGAIFTGAEEVKTAEQAALWGGQVGVAFDSQYHKAGDDINNLNQGAWIQNTKAAAHVIATYARSTETIPKRSLPKRAKRDNKHAISGAYGSEPVHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A899</accession>
    <name>A0A2T7A899_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1168028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A899"/>
    <dbReference type="STRING" id="42251.A0A2T7A899"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="49"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="484" mass="53176" checksum="2F088762B13FC9C3" modified="2018-07-18" version="1">MSETEGAHSEEMPTQLTQEGQQVQYKICWDGPNDPENPRNWHLFKRCYNTLVPALLNFAVTYGTSVYTPGVPQIMAQFHVSRTAAFLPLSLGGLGLAFGPVLGAPISETLGRKAVYLGTFPISLLASVGAAESQNFGTLLACRFFAGLFGSPTLAISAGTIADIWDQQEGWGSTVSAVTILAPFAGPVLGPVVGGYTILHRDWRWLMWGVVLVGGPIYLLTFFTQETYKKTILARRAKGSEIPPQPGPTGVEWVKSILTLNLFIPIHMLFTEPIVAAISLYIAFVSGVLFEISARYPYAFGKVYFFTSGEVGLAFLALLVGLLASIATFEICNRAALREVNPHGGRAAPERWLYASMLGSLGIPISLFWFSWSMRKDAYWVSPILAGIPFGWGILCLFLGTSRYLIDLYQSPNGASAMAANCLLRYTFGSLFPLFTPSMYARFGIQWAEILLGFISLLLLPVPWVLFKWGDKIWARTQYPVAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8K7</accession>
    <name>A0A2T7A8K7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_961517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8K7"/>
    <dbReference type="STRING" id="42251.A0A2T7A8K7"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="98"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="278" mass="30734" checksum="6C46851569E4FDE7" modified="2018-07-18" version="1">MVNLFLLILSFPIGTIMALTILGRFFKAGRFYARILSCYFLLVTCAAYGVLASVALRLVGKVSIAQWTTARAFKNLTCPIIGLEFKVENEGVLDTRPAVFVSNHQSELDIVFLGRVFPKHCSVTAKRSLKYIPFLGWFMALSGTVFIDRTNRKSAIAAFDSAIQEIKGNKQSVWIFPEGTRSYFSKPELLPFKKGAFHLAVQAGVPIVPVVVANYSHILHLQDRTFESGVINVKVLDPIDTTGLTTDDVDALVLSTRENMLKELKLISATGVKAEKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A904</accession>
    <name>A0A2T7A904_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1118054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A904"/>
    <dbReference type="STRING" id="42251.A0A2T7A904"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF7">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU84209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="450" mass="48266" checksum="9E3E7F1321F34AFF" modified="2018-07-18" version="1">MANITSLKPLLSHSSTFTIPGGAFAEDYNNWTNYALTTPKAVIKTTSESDIQTVVKFASEHNLRVSVRGGGHSTFNSCDGIILDLAGWDEVVYDDGDDTIRFRPGALVGKVVEVAGGRGRCIMSGTCNTVGMTSLCLGGGLGPLTPKLGMAIDSLLSARLITASGELLTVSPESNPEVFHILAGAGQTLGVVTEIQMKTYPINETLNTVDETVFSASVTFPASRAAEIGDFLSSMKWDENTAVYLMLLSPPKGGGLLFIFSVNYYGSDEDAKRALKVLYDLKPIAETTSRVPYVQGGQDEAVGERGGFKRMAAVGLKRVNAEGLKGMAEALENLLAVGDDLGKSCVLLEFLGLGAASKSSVGVYPHRDIDIWCIPIAWYNRPENHESAEKFGRDVRKAVKAGDVSEDMVVYPACRAGDEKPEELWGNKETADRIAEMKAKLDAKGVFLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-03-01" modified="2025-02-05" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q8X141</accession>
    <name>Q8X141_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AMT1</name>
        <name evidence="12" type="ORF">B9Z19DRAFT_1122662</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2002" name="Fungal Genet. Biol." volume="36" first="22" last="34">
            <title>A high-affinity ammonium transporter from the mycorrhizal ascomycete Tuber borchii.</title>
            <authorList>
                <person name="Montanini B."/>
                <person name="Moretto N."/>
                <person name="Soragni E."/>
                <person name="Percudani R."/>
                <person name="Ottonello S."/>
            </authorList>
            <dbReference type="PubMed" id="12051892"/>
            <dbReference type="DOI" id="10.1016/S1087-1845(02)00001-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2006" name="Fungal Genet. Biol." volume="43" first="630" last="641">
            <title>Gene expression profiling of the nitrogen starvation stress response in the mycorrhizal ascomycete Tuber borchii.</title>
            <authorList>
                <person name="Montanini B."/>
                <person name="Gabella S."/>
                <person name="Abba S."/>
                <person name="Peter M."/>
                <person name="Kohler A."/>
                <person name="Bonfante P."/>
                <person name="Chalot M."/>
                <person name="Martin F."/>
                <person name="Ottonello S."/>
            </authorList>
            <dbReference type="PubMed" id="16698294"/>
            <dbReference type="DOI" id="10.1016/j.fgb.2006.04.001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12 13" key="3">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="AY050276">
        <property type="protein sequence ID" value="AAL11032.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8X141"/>
    <dbReference type="STRING" id="42251.Q8X141"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="40"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAL11032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU81027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="483" mass="51909" checksum="6DB0A7CEE05F4973" modified="2002-03-01" version="1">MNDPDHLNYVPLVPFNGTKPFGGDSLTQDLNIWYESGNVAWVMTSTALVLLMIPGVGFFYSGLARRKSALSLIWLSMMATAVVSFQWFLWGYSLAFSHTGGRFIGNLDNFGFKGLLGYPSIGSEKIPDLLFALYQGMFSAITVALAIGAAAERGRMLPCVVFMFVWATLIYDPIACWTWNSSGWSFRMGGLDFAGGTPVHISSGSAALAYSLMLGKRRGHGTHELNYRPHNVTHIVLGTVFLWVGWFGFNGGSALSGNMRAVMACVVTNLAASVGGITWCLLDYRLEQKWSTVGFCSGVIAGLVAITPGSGYVPSWAAVIYGVVGGAACNYATKLKFVIGVDDALDIFAEHGVGGIVGNILTAFFAADYIAHLDGSTEINGGWLNGHYKQLGYQVADSVAGFAYSFGGTCIILFIMNLIPGLSLRATEEAEILGIDDAELGEFAYDYVELTREVISDDDTVPKMSSENNASVELPAERAEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9H6</accession>
    <name>A0A2T6Z9H6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000790">
        <property type="protein sequence ID" value="PUU72129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9H6"/>
    <dbReference type="OrthoDB" id="5483538at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="355" mass="40397" checksum="5FCFE766402544DF" modified="2018-07-18" version="1">MSTTISKFHLFNTTLEIEKYTMENNTDRYWDFEKRKVIMFKNVQSDDEIGIIINSGCEAVGIRGTKLELASISDYNNLKDCIRKKWLLITGPNWSGIENYHQEVISSRVAYSAIAAMNYSEGQGQYTIESSHQVNPLIINQQSSAIPLSTTSQSSLHHLPDHISLSSLSPTALVNQSISLKQTITEAIPSPCPIPPFSIFRTFSQSDWHDCLKSNNICDFSTSSIEPIGLTTEKKEGVIDDVRKLDYTQDLLSSMRAKLEFSFYLRNHDLKVVDQTSNILKEGETIISRIEYEKLLDSKLKLSKELESLTAGNVGLEQRIEAMEKEDKNWKIKEESEKMESLKLVEDLRNIIFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9W9</accession>
    <name>A0A2T6Z9W9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1765-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1011148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000592">
        <property type="protein sequence ID" value="PUU72292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9W9"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9W9"/>
    <dbReference type="OrthoDB" id="296767at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013887">
        <property type="entry name" value="UPF0592"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37988:SF1">
        <property type="entry name" value="UPF0592 MEMBRANE PROTEIN C7D4.03C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08578">
        <property type="entry name" value="DUF1765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="103168" checksum="A997982B0D27E213" modified="2018-07-18" version="1">MEDTSYQPLVSSASNASLDFKTRPAPETLVSLAHRSWNSPNVSRSPSPSSRDDRSSRDENDSRSTSSLSSTSPTKANGAEDSVESRNESQPARPDLNRSPSLMGKARRPLSMFMRSSVSDSSVPSATLKKAYVGSTDSVGSLGERPTLKKVKDELWEAYRLLENDFQRFQSKSTAQKANIIWQSLIPFLRKFESKSTPHIAPDELDRRVRVLHRWWTGLMAQLRIRNSQAIAGADRPAYLEGISGIFSRPEWRSATSTFAPVNQRLPASAKSRSSSSLASTSSAYSLQKSVQHNIKVLFTRTLYDTLGFTVEKMGLRTSPPSMVAFGGKVLAYAFYFCPGVADMLISLWEIQPATVRRVLPEFGVGRGTDLRQVSEAIVSDFPETLQSLGFTTLLATLRGMKQPAKPPIGIQVDWRGAWTSRWNGRDSDLLYVFLRYYHILMYDYLPPDVSPLARFTAPGYVMVQAHMLSLLDNTIHRQPTLTGADSLASTTFEDMLANATVTLPMAARNPARTMAENKMVVLLRDVMSDKVNFSEECRIMYITSFMAMIKGAVRKTRVYDADACFTLCDLMEEILPLFSQAEQLYNTTFVDWPFWMDVLKQMPESENNMTELRLISFVYTAWDLIVEDEERKRTICLDWLLSEAVWEKYFCHWCPMVRAYFMRLACWRLGRYDGSPNPLDLDILKTLLRRLRTAHAHYLRLKDKAEANRTPLPSTAPCLPQPCRRLLIIRSDVLTTPQGVLLDGVIPTAAPISSPESLPRSNSSMSLTSISTATSDAQTILSSDIVDTTRSAGSPKRESSPTQQQSARQQKKTTFKFALDWVDRPPFGNRERRLGPARIPSAGQKYVDAECNVPLSVDLSGYTGNASHWTYVGRALAEWVVVVMEYENFFERRKNEGKEADKDIETPSLVVDSARKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9X4</accession>
    <name>A0A2T6Z9X4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1138312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000606">
        <property type="protein sequence ID" value="PUU72269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9X4"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9X4"/>
    <dbReference type="OrthoDB" id="5418922at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="23204" checksum="5C91DFC1C863FA33" modified="2018-07-18" version="1">MSSENGRTATPSFLVSGSLKPAQLASIEVAKEVWDLVGDENRENFLVVGGTALLLHGYPIMTCDTDIAITADTLYKFENLAMKDPRYAKSPFGQWTFESPRGFTVTIDFLDKTGEAGPLEKCTDYTMIDGIPVTTVEDLAIGKGAAWINRQLGKDFFGFKCAVKKMTETGLNFKQLSQKKREILDDIMFELEGMREEWGVLRVIRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA97</accession>
    <name>A0A2T6ZA97_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1069776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000540">
        <property type="protein sequence ID" value="PUU72421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA97"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="238" mass="26948" checksum="68D6FF20DB94F4E9" modified="2018-07-18" version="1">MHLKDNIAMHTPLRLGSSRQYLGHSKVLIMFLPAFYSYIVANYSLLQKRSDDQMDSSHPVLHGRPPKSKKQQRKDSNPDPFTIQNSTAADVIHLCILKPPKSPTPTSRTSRKPKSVNVLPHTKGSGLMLKSATHNVYLLAIEDAIDSLILAFDIHCTQHPEPTEEPLHEHKLMDTACISPHKITKNPVGNDPEEPVWKWDEPYRKARYYTDSSTATTQETVSLADRIQVIQHKLDHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAE0</accession>
    <name>A0A2T6ZAE0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1010293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000550">
        <property type="protein sequence ID" value="PUU72394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAE0"/>
    <dbReference type="OrthoDB" id="10037289at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="29865" checksum="6DA8F1F31ED8D706" modified="2018-07-18" version="1" fragment="single">FIEFIELQDPNLKLEVNLGHRSKEKEDYNGSELKISKDGYNNLIKMYTEIEKRTTERDRVDLTYGGDSQMGYGCIEVLENQIRQYKSEKKSKHTKLKLYAIVEALVFFEDGPYRDQWTYLDMGGRFNEFGSLIGALFLDCFRELEKETPTGPWLAAPDNTPLKNLGLIMGLAIGAAPYQSFDGPDDWPHKIERMAQARGIQLRNCNGPFEEIEECDFETQVCQPPSSLASRVGVMCLLTTTEPRLKWYTSSYSVGGNKEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAE4</accession>
    <name>A0A2T6ZAE4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1097194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000530">
        <property type="protein sequence ID" value="PUU72467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAE4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAE4"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="205"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="476"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="714" mass="79772" checksum="3C15F415D7FA0B52" modified="2018-07-18" version="1">MDPLSITASVITVVTLTGQLISLGYSYGAGVSGCPKELRDLSAELISFSTILDAVKGVLDPTKNPATGAHPTLIGNSLQNDLDECATQLKRLLLFLQKYQDPAGGKVKKVVKRMMWPLKEQETKDWIRRIEGYKSTFSLALSTDGLHLSRVISVNVLELKRDQEEERRLAILKRKGDKFLKTLSWLSPADHRRNYDTACMLRHPGTGGWLTERDGFKEWLRKDNSMLWVHGIPGSGKTILSSIIIDKIYDEIKQTDAELIYYYFDFKEATKQTSRNLYGNLISQLLEHDAEVSPEVERLYDDANGNPPSLDDLKVVLTNLLAARPKTVIVIDALDECQDRSEILDNLSKLHEPASGKVNLLITSRQETDIKWAFSGAPSIAIKPADIKDDIKSFITKEIERQPKLRRLPPHMKAEIMSALSIGADGMFRWVKHSLDRVARQRSNKAIKSTLHTLSRDMDQTYERILANIPPEDAILAQRVLQWLVCSFRPLTLEELVEAIAIEPGACALDRATLLNDPEDITDICASLVSLSDDGKTVGLAHFSVKEYLISPQIASSTVAAPFRIDLEKTHVLLAKRCLTYLSFEDFELGPTRDEAEFEERVNDHSLLGYASQNWPLHALHYAPDQDDIEFLALANGFLNPSAPSENLLAWAQARHMEEAGAAGRWDSYLDCEVVKVLVKNERQGIEALMRDPWALTGCECFGGGASGARRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAL2</accession>
    <name>A0A2T6ZAL2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_675946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000531">
        <property type="protein sequence ID" value="PUU72464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAL2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="22133" checksum="6792ABEAC36B4171" modified="2018-07-18" version="1">MVIHYGTITVTSKRSDNRVSNLAKSIGIHSHNNGDSRDLTPSSRMWKSDLVSNLVANPPLPPHQHLPPPPSPYLQSSFKPQEQADERNKSIAKKKERELAKKFPQPPTPQPRCWKRQDRKRKTKKRPPRKPPFRRSSLGPLDQASHPHTPHSKHQPPHIPKSHESSIPSSTTCVSRTPTAMTRKMPLDSPPPSVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB97</accession>
    <name>A0A2T6ZB97_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1136753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000468">
        <property type="protein sequence ID" value="PUU72765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB97"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB97"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="4">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="133" mass="14929" checksum="71173A49C8FE81C9" modified="2018-07-18" version="1">MEIFRKSVSKYKKAKVEPRSAVAAVGTQSISQPGTHITMKPFHSASIAPMNVTPGVPLIKESSTLRRLLAPLTEERERDHAIRTSQNARQLASFEKTTDPLFETVFYVKRDAVKGVSECILRTYSFEYLVLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBE6</accession>
    <name>A0A2T6ZBE6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000462">
        <property type="protein sequence ID" value="PUU72812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBE6"/>
    <dbReference type="OrthoDB" id="10585805at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="401" mass="46784" checksum="B33396B994D38EEA" modified="2018-07-18" version="1">MPRLSAARRKQLESARQKIIRVGAEPPVSVKCKREIRILTGRAAGWIGSEDDSSETWTDEDEEFTEGNWTSGNWNRLDDSESEFDIVSNLSDKEVDLEDLEEDKSRAPSNKDIAFSSLGYQEMRDEKSAFDVMQMYYEDSQLGKDPVESGERKGDNREDESRKRYEFGSRRSFFRNKQEARERAKTASECYSIAAMFDRQKALGISIKEEDKKFKYGPVGSSAEYETGEDKDDENATLLFCHREAREEELEDKEWARQPNFIDLPRACLHPDEEYIKKWEKGMRDLHHLLKHKTVLTKHFAKEQPNPATLRRYYMVRSFMWAQELSPDDKRRIIALNVAKSYFRGGYTARQIIKWEREWVENRTIQPSRQGVHERHTVGTLLYDESIILTAREYIAKAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC64</accession>
    <name>A0A2T6ZC64_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1111439</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC64"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC64"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="13549" checksum="EFA85C8E70040F24" modified="2018-07-18" version="1">MATTTTTTMAISGTRKNGKSWKPAKTAFRPKAGASLSWEARLEQRLALAATKLREKEMKEEKEAARQERNRVLKERREAKVEKERYERLAEKMHAKRVERIRRRERRNRALKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCQ9</accession>
    <name>A0A2T6ZCQ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1005397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000395">
        <property type="protein sequence ID" value="PUU73263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCQ9"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="600"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="889"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="224"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="916"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="937"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1382" mass="153805" checksum="96E9B16BE3475DAD" modified="2018-07-18" version="1">MPPSAAGPGSGPGGPILNVGGPLPTAPPSRPLPFDILPSTAERDFDSRRASSSLGFQGAHGHLNVKDALSYLDQVKFQFQDQPDVYNKFLDIMKDFKSQAIDTPGVIDRVSTLFSGHPSLIQGFNTFLPPGYRIECSQDPRDTKITVTTPSGIHHAASGGEVSIGGDRSGMQLNTAPLGVAVSSANGPGQGQHSIFYEQQVSRWDPAYGHGHGLYGHQSGTGGPQQSQPPQQQSEPLSAHHLHQQQLVQAQVAQQQAQHQASVQQGVNQLQSAAAHTNGSGVKGPAGLVVGGPGTPTAGANDPKSGKGPVEFNHAISYVNKIKNRFAQQPEIYKNFLEILQTYQRESKPIQDVYSQVTQLFHSAPDLLEDFKQFLPESAAQARAAAAAKAAADEAAGHTGHIGPNGPPGSGGAPSASRLPPVGNFPPPPSVGKENKKKRGAQGLSAVQEPKAENNGANGTSSALRGSKVCDPDTRHKAGHPAKPSVAEQLVAVSPTLIPFHPEPLGPQPQPMATTEELAFFDRVKKFIGNKQTYNEFLKLLNLFSHDLIAKDMLVDKVSNFISGNKELMDWFKRFVGYDGKADDLIDNAPSTVNKVRLNLCRGLGPSYRLLPKLEAQKPCSGRDEMCWEVLNDQWASHPTWASEDSGFVAHKKNQYEDILHRIEEERHDYDFNIEANSRTIQLLEPIAQRIANMTPEEKANFRLAPGLGGQSKTIYQRIIKKVYDKEKGLEVIEMLHNNPVVTVPIVLKRLKSKEEEWKAAQREWQRVWRDQTAKVFWKSLDHQGITVKANDKKAFSMKALVNEIQAKYKSQDVRRQSSTTPIVEHQFMYTFKDFGIILDASRLLAVSLEHTSTFSANDREKIDYFIKSFIPLFFGMNSRDVEDTVNSIARKSPDDDGDEGSPAAGESSTRAGRRSRQDDLLKDVLKRGTGKNGKSSRKDKEGSVASRGSKESTPEVNQNDSDIEMALDGPPDRPIKEEQHWISRPTKHLPDMKPGTPVSHADESSLPVKRTLFTLYANTTIYCFFRTFQILCKRLSDIKACEEEIRNDVAIRRQQKAAHDLHLLGSSSVPGSSKMEELFSDTSPNANYYSQVLDHCEKFIEAELDSNAFEEGLRSVYIQKGWQLYTIDKLLLAILRFIQLIVPNDSKEKSSDKGGNADIIRLFKCDRERREFTKERGEYQELISYRRSIEKMLAPEDSVYRIDWNEENKEATIRYVPRNEMTIANELDKDERWNYYIQTYMMCAPTEGIPLGRCDKVFLTRNRPSEDDLPEDGSPREMIGSSAADGFCNEENMEIRICVNTYRLFFAPNTEDFMVQRRSQRLAGESKMQAVSGKRTNKWHDFLNNAPWMQNMSQEEIERKKAEWEVAKANGQPTDVVMGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCX6</accession>
    <name>A0A2T6ZCX6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1103967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000386">
        <property type="protein sequence ID" value="PUU73342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCX6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCX6"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="127" mass="14105" checksum="6FD2B133DD25E859" modified="2018-07-18" version="1">MATAVPTLSEDDLTSLLNRISQKNTVQSLIILDRSSGAIIRSSGSIAAHRDSESLVGEYAGMVWNFVKSAEEMVCGMDEQDDLKLLRVRTKRHELVIVPGKSYARYPTQLFADPRFILVVFHDTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD46</accession>
    <name>A0A2T6ZD46_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1004491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000377">
        <property type="protein sequence ID" value="PUU73418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD46"/>
    <dbReference type="OrthoDB" id="5402048at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33221" checksum="44C9F17577C855A0" modified="2018-07-18" version="1">MPNIARFISSRQTKEFFFWKKYTTDLTGDSALRKTVVEIQAADLGKVYVHRALLNREVTAFEECGWPCFPSSTVASFVEYLYQGHYTSPPVELLPYYSGSVNTNALAGQARSSNSVTPPPAGPLGYGKAFLTHAGLFILARRGKVLPLASMCLTRLKEVMREARDTAKESMFVENMRTLIRFSYDPCCNGSDGVWEELQKAVCGFMVSQRGWLLEALGSDLICEEEQFAKDLLAEAINLLIDTDKLRVAAENSSEAIRLAAAIPGNRPGRKKKRQALIISILVKSMKSPTLIVWCFSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDD4</accession>
    <name>A0A2T6ZDD4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1094967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000371">
        <property type="protein sequence ID" value="PUU73507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDD4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="94" mass="10580" checksum="BAB29B2721690C5F" modified="2018-07-18" version="1">MSFPEPFIHLLGFISVCSSFGINIWDHGIVLGEHPPTWVVCVRALLPCCSKFPGCRPQLCTVPLEEITYYHSKPLLEDTVFLAPLIPWRVSVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDU5</accession>
    <name>A0A2T6ZDU5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_518577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDU5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDU5"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26659" checksum="3B8189BEA385CB03" modified="2018-07-18" version="1">MGGKRTHPGRRHPFATAAKDSCYGNSPFPTLLPSIQHAFLCHYRRLPRRNILIFKAHGTSGEASRHYKQYYVTEQEYYNKRTRLLNVETEILRACGFQTHLSLPYTLCINYIQSLSVLSAEVVKKSFGYLTDALLSPSLLYLTHQPNSLAVAAVYIGARECEVKLPAAWWDVFDCEREELGFLVVCIKGVKEFIEGERKLWRGRKPGIPWELEDLEMHLERRRVLDSEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDY6</accession>
    <name>A0A2T6ZDY6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDY6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDY6"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="478" mass="52440" checksum="2E43D5E3EBAE0E50" modified="2018-07-18" version="1">MARRKSAALKVHKDEGPTGASLDAKLYEGTIPEALSYTLSEEKSDPEDMHPPKKKMRRHEKTGPVASPVGAEEGYPGGVSAAAAAVRPRTRAHATISSTAAVCSRKRDQTDAAVTASEGPERKRVALKEKNPNPSSSDIHSTDLHRSFPHKSKLKQNAETSNLKDDAAAAPQSGSVVDKGTSLLQESFAVGGPVYRALKELLPQKDFRELLELVEEDAAQGVADLVTKKNCWSPELLDSFRGSELRLLDLSTPSSSPSEILVPNKPPTLILRSLYRQDQFAALATLSLRNTQLLNNDLSLLMLLTSLADLDISNTGLGVHSLHHIVCHHRTLVQLNLSHNQGMDDDCRVPLAALPNLVRIYLRGTNISMPGLRRLVTGALPGNCRLLSLPNHCIAYLNDRESHYSMDIPDSYAQDPWKLENMNLSELKKNLELHAKVNSGIPLTGSKSELFSRLNSILRNRLADTRIVKMLGREERQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEE1</accession>
    <name>A0A2T6ZEE1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1117179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000337">
        <property type="protein sequence ID" value="PUU73860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEE1"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="302" mass="32951" checksum="A602AFA5CE074BAA" modified="2018-07-18" version="1">MGVPLSQPIVNKISESGEDNRLAYGISSIQGWRVTMEDVHAAVLDLQNPDDPTKAGSEGRISFFGVYDGHTGDRVANFSGENVHKILAKQPAFKDSNYEQALKDGLLSTGRAILQEKANAGDSRTPLSFDHKPYNEEKARICATGGSVDSGRVNGNLALSKAIRDFGYKMRADLPPEQQIVTAFSDVVIHEVSDDEFPVIACDELHSICENMMEDNMTMIVVALLRNAMTKEEWYGLIPKRVADGDSPCSPPKYAKFRRPGVHPTNFGGSPVEFDIRIINSSIRAIGGAVSTDSEDGEVFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEF8</accession>
    <name>A0A2T6ZEF8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEF8"/>
    <dbReference type="OrthoDB" id="5344540at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015524371" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19918" checksum="43E25AFF35503BC9" modified="2018-07-18" version="1">MFTSKITIILFFFMAFALLALTHPVEDQPESQTFATTPEDVAALAIINDPTPKFFANITFTDEVTLQNITAQASYICDTTSGSPSVHWLREISGRLRGEFHNQQCKQRNELGSRCTQLIAMGDAAASICGSYTRWFACDYVGFAGFWITDHCAWNGLAGGRFFVEDKFDTKFTFHKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEK8</accession>
    <name>A0A2T6ZEK8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000332">
        <property type="protein sequence ID" value="PUU73937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEK8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="14514" checksum="49FEC608A9F841E9" modified="2018-07-18" version="1">MTGTDKPNGAADAAERLRKVARGEPIIDSSIEPSLPNSPSPLAYNPHHDLASAVSEQLQVRISAEHLLMLASSTQQPANNVVVDTIVANADDALMNMPVVDARQESGLAATTPASSSGYSTPETNFENPLQFASVLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEX4</accession>
    <name>A0A2T6ZEX4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_490282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000327">
        <property type="protein sequence ID" value="PUU74022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEX4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEX4"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="147"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="439" mass="48648" checksum="AA79EE73F0D9AD56" modified="2018-07-18" version="1">MSAPTQLLRPMNPHNGPGPRVPRLGLSIPPQPNPRPVGAPQLVGPTRGPPQLRLATPGNPNANGIQPVEQRRAQAYASPVNTVSNQYSALSYAMGLKNQVRGSPESAIPRTASKEGASKTINWDNDNLDVEDLDDEGWKKASEDGRIVELGGLGEGAGGAVTRCMLKGGKTLFAMKIITADPNPEIRKQIFRELSFNKECNSPYICRYFGAYTDLSSATISIAMEFCEGGSLDSIYREVKKLGGRTGEKVLGKIAEGVLEGLTYLSGRKIIHRDIKPSNILLCRDGQVKLCDFGVSGELIGSKGNADTFIGTSYYMAPERIQGFSYTITSDVWSLGVTLLEVAQHRFPFGEESDSTNARYNLIDLLTYIVQHPIPELKDEPNLKIKWSHNFKYFIACCLEKDTQRRASPWRMLEHPWIMEMKNKKVNMANFLSQVWDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF09</accession>
    <name>A0A2T6ZF09_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1133895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000323">
        <property type="protein sequence ID" value="PUU74088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF09"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF5">
        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="313" mass="34806" checksum="B9C7CD3E757DC4B0" modified="2018-07-18" version="1">MKVAVAGTAGLAQHITRAVAEEGHEVFMLSRYQRPQLAEKGFRVIQVDYFNPESLHAALIGVDTVISTVSGTPQLALIDSCLSACVRRFAPAEFEGVPYERPMIEQGREKIDTLNRLREVKEKLQSTAFCCGIFYEWFGPGGLSRSGVSAGTILEATPTGRVFLGDEACYMLDFRNERATIPAYTEKGDDVYACFTAAADVGRFVAKCLKMETWPEQLKMRGERLKLLDFVGIAEAVKGRTFNVTIIGSEELHEQAIDADEAEDWKQVSKLEVLIAAQRGELDFLRANANDCYPEVETLSFKQWLSKAWAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF85</accession>
    <name>A0A2T6ZF85_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_481972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF85"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015762611" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14564" checksum="757B533219CDD418" modified="2018-07-18" version="1">MSLCMLLCLCPVRSETSLVRSRPTIMSVCCCRYARSCPGYRRKAAALMKLVQLEPILVMKAALMNKASESLYSSMVSWQTHSIELTSPTVLTVNRRRILAFLNPPNTEVHAAVSVLLIPSYLHPIHHELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFN3</accession>
    <name>A0A2T6ZFN3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000309">
        <property type="protein sequence ID" value="PUU74279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFN3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFN3"/>
    <dbReference type="OrthoDB" id="5414467at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="380" mass="42694" checksum="CC1386785E9533C5" modified="2018-07-18" version="1">MQKRVDHLIAIKAFTRQSTPIPSGTSFESAVKALLEKWEDERTGYLSVTSPILFNTLSERSRQPRGVLPLITEKPAAVKSFAYYPSSLGILRIRDTRGVILGYRFKIPPHLLTTLNNSSQTLDSCGASNGGGGGRSDSAGLYESRDYTVSAADGKKYAESRELLRDGEKGREWLRENQELFDYCSNQLRFLSPEQYVRMTGSVVKDMAKTQSADGRRLRPLGGAWHGVSLNQETDSESGSRCHQDWSNDKRLFNCIVPFGEGFQGGELVLWQMKMRIGLEIGYGFFFYGSLVAHEMMDVTAGVRNSIDLFTHASNYELLAKHEQAAGKVKYPAKQKKPRSTKKKEEGQTVKENVATRRKIREGKKLRQSATSAMRIKREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFS1</accession>
    <name>A0A2T6ZFS1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1056355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000305">
        <property type="protein sequence ID" value="PUU74351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFS1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFS1"/>
    <dbReference type="OrthoDB" id="5413892at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012917">
        <property type="entry name" value="DUF3294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07957">
        <property type="entry name" value="DUF3294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="12925" checksum="A4DA60EA2944789F" modified="2018-07-18" version="1">MRVLKDTAEGVAKVVQGQATILRKLEALQDRQDAIEKNRIARLINSRAKRDNTVLEPFYGFNGQLVLGFPRTLGDTKRLNNLDLTVLLFALGLPVSGSFAVRKARFFNHVGLVYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGF1</accession>
    <name>A0A2T6ZGF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">C2 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_999870</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000291">
        <property type="protein sequence ID" value="PUU74567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZGF1"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="120"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="321"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="468"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="600"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="947"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1230"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1144"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1355"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1159"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1355"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1365"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU74567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1379" mass="151738" checksum="063A26B2B9122571" modified="2018-07-18" version="1">MINGQPKAGDGEWSMVGWEPQFGSLNDTFGLGDVMAEDHQTLLEGKLDDKFFGDWYHNAGVIGFACLSTWFLTLIGGGLGWVIIVMACCATYYRTSIRRVRRNIHDDLNREFAKSRLDTDVESLEWLNSFTVKFWPIYQPVLSATIVNVVNQVLEGATPGFLDSLKLTTFTLGTKPPRVEFVKAYPKTEDDIVEMDWKFSFTPNDTADLTSRQLRNKVNPKVVLEVRIGKGLASKGVPIVVEDMAFSGLMKVKMKLQIAFPHIEKVDVCFLGRPTFDYVLKPLGGETFGIDIGFLPGLSGFIQEMIHANLGPMFYAPNVFTVEVAKMLGGAPIDTAIGVLVVTIHNAHGLKNPDKFSGTPDPYTVFSINNREEIAKTKIVNENANPKWNETKYILINNYNDSLTMTVYDWNEFRKDKELGVATFALDKLQENPEQENVVIPVMVGGKPRGQVSCDFRFFPTLEGTILEDGTKEPAPESNTGILRFTVSQAKDLDSTKSLVGFLSPYAIQTLNGKTINKTKPVKRNNNPIWEVSKEILVTNRKTAKLGLQIKDDRDIAADPLLGTYTIKLDDLIDKNTKGTEWFDLSETKTGRVKMTAQWKPVAIKGALGGTGGYITPIGVMRVHLQNARDLRNLEALGKSDPYVHVLLSGIEKARTVIFNNDLNPNWDEVLYIPVHSPRERLTLEVMDHESVGKDRSLGHLDVNCDEYIKKGEDGLWLEHSEKINRSEGLRLDRGIKGTLNFTVAFYPCLNVADPEKDEAERKLKEEEDEKHEQAVEQKAEKSAIDIENEKSKAQIKENTLAEAAAGSDSDDDEKKIPKIRLTPEELVKYDSGLLIFKIIEGQLTHKDCYLEVLMDDMLYPAYSSAKIGSKNMKFDEIGDAFVRELEFSRVTLRLREHGKDGNEEDEILGRLAGSTLETVKQCLNNPTFLSLKDRDGGVSKIKISLKYIPVLMTLDPSESINNMGTLKVDILDAVNLPSADRNGKSDPYCVFYLDGKQLHKTDVQKKTLHPSWNESFETKVVSRTAANFVVDIFDWDLAGKADFLSKGQIDLAQLDPFTPKTVHIKLTGKQGQEGRFGELRLRLHFRPDYITRSRQGSSTFHGTFAAPGKIVTGVAGAPLRVGSFAAGGITKGASFLKKSAFGRKAKDSNGVTEEIDQETPTPISAPSNGGAAKGSSEGGVAAYDPDGNQVALGGSEDNLDPGQRAPSKRAGLSPAPSSAGSPHNRNRSVSSTLSVPGGAPGGADPGTATVRIVGASGFPTNANVQLRFKTLDKGKELHKSKSVKSSTGELAWDESFTFNCTADQQFKVYAKDNHLLRGDEELGEGLFVVDDTGNGGDTVVPVGQGKVVLRTSFKSSETASNASPRHKRGLLKVRSHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGL5</accession>
    <name>A0A2T6ZGL5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1132944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000286">
        <property type="protein sequence ID" value="PUU74625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGL5"/>
    <dbReference type="OrthoDB" id="5496133at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="335" mass="37347" checksum="BF88E4D258E38EA2" modified="2018-07-18" version="1">MSSESRINESSTQNSQPQENQTAPLAASEQVGWNPDPIPQVADLEEQNRFHHFHREWVARTYGVQATSLPPQHFFQDPTYPSYLRNTGLTLLDTQYNNVQHEQQAANLYPNPILLPTNIEIRHRLPTAPICTTTTPIAGPSQLPQPNRAHQFADRPIPVTPKNRLTNEQKEIIKRTERFDCSVEAVMGDILIQAKVHKSACSESRSGVAVAATDLDQAAVMWSEIVRKKEEMLAGDKGGEKDKQDNQETLSRLRLAMTQRLAERGEIELVEGVDLPALSASMMELADHDASTGEGGNTEEEEGGDKEREKGKKKREWKERPGAGMSAGKRQRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGX0</accession>
    <name>A0A2T6ZGX0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1092086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGX0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGX0"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="661"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="879" mass="95707" checksum="822E989B1B8B68C5" modified="2018-07-18" version="1">MGEKRKRTVAVRESHPSKHRSATPAAETPIPEEQTSTPEVPTSFAKDGPLPVIPQRQLDGLLLSDYKSVAESKVMSESLIRSQRKWVDGDIFEKFWIKPLKSRKLDPAELEKNPSKDCMTRLGNCTMSSMPHKFEIKLFGVLEPPQPQHPIQKQTLPPTPQLGISENTASGRCFTPHNGQSSGAGVQTPSAHHQVLQQGVARTPDPARTQSSPALVTPVPHQGATSNPGDNPGISSQLPTLGQPLHQGPQQSHPPQQGPPRVAPPPAAPRPDPVIQALAIRAASDPDLKALMRIVASGKATTEQLKIFQSHIDALTPVASSQLIHNHAARPPTQPPGPSGAPGSGHTAQISHQQAHPSYQQRHHQQPQLQHTRHPQPQHQPQHQPQHQHQHHPQQHHPQQYQHQPHSQTQANSPQFTHHPPQFTPNRIPAPHLVHTNPKPRPFPQPPKQEITSVVFEFVDPYSQGDRFLFPKHAILEYLKGGTMVRASFILVRKPVDDLDEYYQPMTVVLESATPKPLEILQRVVASPEITRKHMEEIMASKKRAEDTFLVFRLRRELGEAILDKPEVHEKAESTSRVLRERRARRESSTPALDLKSLVGTPQAAPSRPRVKTIKKAIPREPTTQPSIPSPSTSAVRTPVLKVSKPARPPKPPRSRKGRIADPTKSCHICQTSKTSLWRKADIEGENVTVCNACGIKWKTNAQKAAQAAAQGVTDQPLPTDGADLSSITVRPTTQQLAAGAPQMQYNQHPVGSAVNDLSGQQMHTDTDQVPGTAAASSAPVPYSQQYPQHAADVSVPQPSSPQQGGNPQSPPLMGGLQPAGSPGKNSPQSLPLVNGTPQGLVSGVIDRPPPPQQANPEKPMDQNGSTAQDTLGGLEDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHF3</accession>
    <name>A0A2T6ZHF3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1132208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000260">
        <property type="protein sequence ID" value="PUU74928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHF3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="20326" checksum="D2CC9C803758CE6A" modified="2018-07-18" version="1">MVNFGVVMADIMKKMGYMEKEIGRLRHHVSVLSKRNHWLELEAKEKDEEKEEVAEENAKVAEVAAGKDAVAAEVTLTEITEAEESVVGSGSSVMELDRSVEELSSRISDEDVLVDEKIVPLKVYDLEEKRRLSRELRALGVPARLRGQGAGGRSMGPIRGRGQNFVFGSEVSRGRRQFRERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHF6</accession>
    <name>A0A2T6ZHF6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_392076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHF6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHF6"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="10">
        <location>
            <begin position="165"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="354"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="437" mass="47763" checksum="92844B8AE0D3B8BB" modified="2018-07-18" version="1">MGEWEGNINSPILTHARILVSPVTLLPLDDQLQPIPMSFSADLPIPTDNTEIPRESPPLPPPPSDSPSAPSTTAPEPTTTTTTTTTPDPQSTTTKLSKNARKRQLKAKHWAETREAWKAAKREKKKVRKAAERAKAKAAAEAAAEAARETGGGSGKQGDNGNKNNGSMNRRRPVLEPITFIMDCGFDDLMADKEITSLSSQLTRTYSVNRTSSRQVTLHLTSLNKRLLTRYQTVLSNQHLRWKNVVVSSEPYEVTPDLVYLTADSPNTITELENGKKYIVGAIVDKNRYKGLCHKKAVAQGVATAKLPIGEYVSMASRFVLTTNQVAEIMIRWLECRDWEKAFLEVIPRRKMPVAKGGGEDEEDGEGEGEQEGEDVGDGWMPVEDGYNSPTPADNLDKAGDKMDGIENAALIDGERGDSQQKNTTSGQAPGAMDKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHM6</accession>
    <name>A0A2T6ZHM6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_996639</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000257">
        <property type="protein sequence ID" value="PUU74979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHM6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHM6"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="6">
        <location>
            <begin position="12"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="7">
        <location>
            <begin position="417"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="5">
        <location>
            <begin position="772"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114898" checksum="DEC84C3E41ED6C36" modified="2018-07-18" version="1">MSYVATLYEASSVRIAIKAEFLAAGETSLIVAKSSHLEVYKVAGPGIILQEKFPIYGRVIALSAFRPQKSETDHLLIVVGQINYQYFTISWDPVAKKPKNEHAAVDFSDNHAPLSDSFLCLSDPKNTMLGLHVYKGIFLTIPRTQPSIKGGRKSQANPDLGNIREHCFVRLKELEILDLKFLFGTVLPVLAVLHKPFNGDEMAVNTYELSIRSGEAKLSDWTIRDLKGGQEALFLIPVQLPFSGLLLIGVTKIQYFDTVGSKTFQPVDPPIVWTTWEMLSPERYILGDEEGGLHLLLLSVDTRTRKVRLRLNHIGNASIPETLVHLGEGLLFLGSHFGDSQLLLIRNEEPMVRVQQVFDNIGPMVDFKVMDLDYSRSEEGIRQYSPGHIRFLSASGGHKQGHLRNIRSGVGLDDLGVLGEMRGIRGLWSLRSIPASSCDDVLVVSFVEETRIFKFDDTGDIEELDDFMGFALNQRTIIAHNTVGGRFLQVTSTAVRLVDADSGTVIAESCPDDGFTITMASANQDLLIYAMGPTLVLLDLRQDLRERIRKTFENEISCLNMPASPSRICAVGFWTVSSVLILSVESFSILSQEALSREDSVATPRSLLLTRILENGPPTLLVALGDGSMFTFALNEITGALYEKKNIILGTQPIRFQPITGGNGKITVFATCDHPSVIYGSHGRIVYASVTADKSTYVTSFNSPNFPDAVVIASEDDLKLSVVDPLRTMHVQSLPVGDVVRRIAYSKGKNIIAAVTVQRVSDLKTGDDLHTSYIRLIDNTAFSVVDSYELDELELAESLASGRVCDGNGSLSEGFIVGTAYLNRREDESEKGRIIVFNVSETKRIKFTASYDTLGSVNGIQMLGERKFVAATGRTVELFVIEYSDFQRKTAAGKPASATGCTITKLASFNAHSSPLDVAVYNDVIAVCDFMHGPSILEYRPDKENESAEFVEVARAFKPSWLTALELLDENTVFCSDTDGNLVVWERQFSGVTADDNRRLRQISSMKIGEYVNRIRRISDQTLAGSKVQPKAYFSTVMCPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI25</accession>
    <name>A0A2T6ZI25_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1091036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000248">
        <property type="protein sequence ID" value="PUU75148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI25"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015425695" evidence="1">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8569" checksum="D6E4D709DBF37AF6" modified="2018-07-18" version="1">MIMLIALFLFALFDSEQLLSYKNSIGVLDSLWVTLSGGFHIISTSVEWLSHVKRVEESNATPGQHKFPYANNLNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIK2</accession>
    <name>A0A2T6ZIK2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIK2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="346" mass="34102" checksum="313487FF4E4E7EA3" modified="2018-07-18" version="1">MRIIKPSQYAPAPHHATLTSPLEMPLFCGSQLKGGTPNGGGGRLGGDALGGGGCQLSGGALNGGRLGGDALGGGGCRLGGGALNGGRLGGGGCQLSGGGGQLDCGALDSGGGQLKGGTHDCSSGRLGGGALDGGGGQLDCGALDSSGGQLKSGTPDGGSSGLNSTVVHSTVVVVNSAVVHTMMVVNSTVVHLTVVVVNSRVVRLTVVVVGSAVVHSTVVVVNSVVVHSIAVVTSTVVHWTVVVVNLTVVHSMVVINLMVVHSMVVVVVNLMLAHLIVVVVGLVVRSTVVLVNSAVVHSTVVGPAAEHSAVVVNHCRNIPTVANGTIKSSSSLTFSFYKVSTTLQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIN9</accession>
    <name>A0A2T6ZIN9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1090507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIN9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015756419" evidence="1">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="10208" checksum="EFF07C083FC3BD15" modified="2018-07-18" version="1">MHIPFALSQLGVVLVVFSPSIAEKGYSKVLTNLSSTDPAITALNSLSIHCLLPNRRRSLARTLLVLFLGARCQYLSHTALLSKELRFKSPSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ74</accession>
    <name>A0A2T6ZJ74_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1131133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000226">
        <property type="protein sequence ID" value="PUU75535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ74"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="63"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="743" mass="82496" checksum="B4DC237DE5187D35" modified="2018-07-18" version="1">MRNFGRLLPKGAVVLRGGNGYSRGVGGESGTSSIELLAPDSEFTQEQPNSFSSIWKPAWHPSWRTGALACATSTVVVLFINIGLVIYATKNPRYGMDQDNIIGTFYSGSCDKSRTIGLWLHLGINALSALLFSGSNYTQQCLAAPTRSEVDAAHVERRWMDIGVPSLRNLFRIKPERAFLWIVIGITSIPLHLLYNSAVYTSLVANDFLVTVVTQDYFEPGAYSNITEALIRNSYPDSLIAHFTKEFSPVLEEYNNSTRSYENLTPAECTKLYNTNFIYNHSNLFLITNRNSNTGHNNTLLDVVRIYTEEASSSCWMCAYDQVQRGPSDTDYLRPAFSCRPSDLTSNVTTRLPWLIKLGTGEEVEIGGCKSERTVEKCKVRLSLGIMIAVICCTLFKACCMITAVVRSREPTLVTLGDALDSFLKIPDPTTIGMCFADRRFIKREWRRGCTVGPRQWKQRGVQRWWTSVGKMRWITCNFFSSTTIVVATVLLWLGMQNDGVVWSTDLKSMWARGFGDVNNVSQFTIPSRGMTRAALLSNLPQIILSFLYLTYNSLFTCMLLGHEWSLFSHRHRTLRVTSPHPGQRSTYWLQIPYTYAIPLMTLSCVLHWLLSQSSFLAVTEILDPLGKKNATIISAVGYSCIAIIFLLTLGILALVTAAGIGYKQFAAEITTVGSCSAAISAACHPAGANSEETTGKKVRWGDVGTEPNLGVRHLTFSSEKGVRKPVLGEVYAGTGERECDCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJL1</accession>
    <name>A0A2T6ZJL1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="2">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_993527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000219">
        <property type="protein sequence ID" value="PUU75672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJL1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJL1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="8">
        <location>
            <begin position="292"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="441" mass="48508" checksum="BF67FA8ADC91C0D7" modified="2018-07-18" version="1">MSTRAEWWTSRQDSRSTSPPSPHDITAATTTTPLVTPRRIHILGSGNVGNLVAHSLRTLPNPPPVTLLFHKFSKLEDFQSSGSRIELRRPLKEVSISYGYDVELTPPPNAVVAANTPLEALVNPNTGATPPPPPQKRIASLIITTKAHQTIAALRPISERLTRDSTILILQNGMGVLEEIKAEIFPDPASRPNFVLGITTHGIYPEGPFTLMQKGMGTISLGYVQRDHPETPDPKGKGTARSWFTRSPPPPSEHPDKPPPLNTLPPSSEYLLSTLLSAKPLEATHLSIAELLSAQLEKLAINAVINPLTVLFNCKNGELLENFYIVQNMRLILWEVSQVLCALPELAALPGRDVRLSPERLYDLVIRVARLTSGNYSSMFQDVRNGKQTEIDYINGYVLDRARDLELACTVNFMLINMVKSKGKIVQGRVAAQVPFVGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJS9</accession>
    <name>A0A2T6ZJS9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Superoxide dismutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_891582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJS9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJS9"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18980" checksum="3F14EC0CFDEADD00" modified="2018-07-18" version="1" fragment="single">LLLAATATSISVKTGNLGDAKVHTDNPTGKQFIASFHGTGAHGNLQFNLTSFNNKTGAFVKLDLTAYRGDEGPFKLSLYEAPVSGNGKCDGAKNVLDPFQRGDKPECDKKSPQTCQVGDLTGKHGEIPKFQGVISVKQSFQDLYLSFKKEDKSFIGNGSVIVKNAKGDKIACGNILEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJT2</accession>
    <name>A0A2T6ZJT2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJT2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJT2"/>
    <dbReference type="OrthoDB" id="4202778at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="38403" checksum="40A5D4B77EF0A3B9" modified="2018-07-18" version="1">MPRDYSENTIWTKAETERIIQWLEEPENLRKIKKGSGITKKTIVAEIAAQIPTKEAIKVGYKYDNIMKSYRAAAKLNNQSGWGLSERDLDEGRRSLRDKLLSRCPYFFRLERILGDRPNVRPPVSYDSGHDANDTAATIEQLLIAISNDNPEEEEEGQLPLVGQEGIGGEVEGEGENGASISREGEEQEREKEWQGEGMRIESGGNEEEVAILRGNGREEEDGGSSDRGERSRVSQETTGGIEEEEVVVMGENRESQGVQRAKRASSSYSSAMRGARKRRFPEMLVAESDNDGASSGTQRRRKGGSNALIEAVGILASAKAEGEEKKFEFLNRILSSKANYDNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJU6</accession>
    <name>A0A2T6ZJU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PRELI-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_993509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000218">
        <property type="protein sequence ID" value="PUU75684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJU6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJU6"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="191" mass="21414" checksum="8AABC21096144AB7" modified="2018-07-18" version="1">MKVFESSCVFEYPWANVSIANWRKYGAWNTQSTHVVAVDTLNRSVDPSTGILRTERLITCKQNAPRWLMKIVGGTEESYVREVSEVDPQQQTVTLRSMNLTGSNIISVQETVVYSPDPSSPETRTRFQQDAQITAYGAFSRICAAIEDWSVERFGQNARKGRVGFEAVLEMSSKAFRDMKDGGGRSEEISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK18</accession>
    <name>A0A2T6ZK18_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1089535</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK18"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK18"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17752">
        <property type="entry name" value="BRCT_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000021">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000005">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000001">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="274"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="916"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="924"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="977"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU75823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="993" mass="110424" checksum="8854E2CDC85B39EB" modified="2018-07-18" version="1">MVTLYGGTERNEDSDDEEKPAKKIAKKPTPKKNTKENKSEPTTTANYFASTGKNKILRTSPRKPKKPEPKEENFLDDEEFDEGIYAEEFKKLEDDYKEDEDEDAKPSFAVVVEKNGQAKSKAKASPPTRRQRPSLPKGGDVNTNSFVVDDAEEDEYVKPKRQSAATPATRKCKTAQLRNEHEDDDDDDEIEQAKPTVRASKPATRKAKAVPKKSKEAPKESESVRKILDSVPIFRPPTPPPPTDGEPKKFNYRDFKQRQGAAPTAPGSKEIPVGEENCLTGLTFVFTGILESLAREDGQQLVKKYGGKVTSAPSSKTSYVVLGSDAGPKKVETIRKLKIKTINEDGLFQLISALPANGGDGLAAKANEAKKAAEEQKVRELAKEMDNETKSKGKEAIEKEATELWTVKYAPSQLTQICGNKGQVEKLGRWLKNWPKNLKTDFKMRGADGMGGARAVMIHGPPGIGKTTAAHLVAKLEGYDIVEYNASDTRSKKLMEEKLRGVLDNRSLLGYFAGDGKNVEHSKQKMVLIMDEVDGMSAGDRGGVGQLAAVCKKTNIPIICICNERRLPKMRPFDMVTYDIAFRRPDATAVRSRIMSIAYREGIKLPPNVIDQLVEGTHADIRQIINMLSTYSTTQSSMTFDQGKNLAKAWEKHVVLKPWDIAQKLLGSEMFAPTSKKTLNDKIELYFNDHEFSYLMVQENYLKTNPARASNYQGKEKNLKMLELVENASESISDGDLVDALIHGPQQQWSLMPAHGMLSTVKPASYMYGGFGGQQFGFTSWLGNNSKQGKLSRFVKEIQSHIRLRASGDRHEVRQNYIPAFYNMLAKRLERDGKDAILEVIDTMDDYFLTKDDWDAIIELIVGPAVLDIPTQTKASFTRQYNSMSHPMPFMKSSSVAAPKASKQDAPDLEDVIVESEDEGGDEDAIKKQAEEEQDLSKDKYVKTKKPKADPKGKGKGKAAPKKNQDDDDDEDNEPKKKPKAASKPRAKAKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKE7</accession>
    <name>A0A2T6ZKE7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1089416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKE7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKE7"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="33831" checksum="AC879C7272EF1B1C" modified="2018-07-18" version="1">MYGGWDGVKAYDDVYILSLPSFEWINAFSGVGDREAHTCHVVGNRMMVTIGGYGAKSGVPGPCDWEPNGVALFDMVNMTWGNVFNPGSEKYNISSLISSRIGGNETGASTIKSPKSNWAPGLEAVFDQQLLLPPGPTNRTNTATVSPQPSSSTPLSKQAIIGISIGSTIFLLFATFAGIQTYRIRRAGANRLRLEAIHTAELEPTTRMPLNAFQELLGSLGKGKNRAALELPGSVPVHTRDRDSNGNPFELPAGGENDRSSLASMLEEVGIAVPGPSHRGSVRASSSKGGGGGSTRQGTNRNSMASVEVHEKIEMNWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKF2</accession>
    <name>A0A2T6ZKF2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_293618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKF2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKF2"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="274" mass="29944" checksum="CF5CC51F6A7EC3D9" modified="2018-07-18" version="1">MDLLTPIRASTLSSSSQQNDAPLLTAVTKPTDSPETPINAASIPQSISNLDDILSTLRSRPSADLLSRTLDLLATNIQPHSSYDIRTPTPKASQVVNTLLETTVPDFWNFLSKKEKKQLAECLRSVTGLGGIVSRLRFLSKSKKDAPSDMSFNIQIEELFALLHSVLRAKGFIHQIWEWGNYGPANPKQTMAWKEFTSLIAGGKLLSVTAEADRLLGVGNGGAGRWIGNESLFISWLGQEVAWASSKIDITNEAEWKALSSMIVRALSLGHRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKJ8</accession>
    <name>A0A2T6ZKJ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orotate phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1130441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU76011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKJ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKJ8"/>
    <dbReference type="OrthoDB" id="5553476at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046132">
        <property type="term" value="P:pyrimidine ribonucleoside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46683:SF1">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="104"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="26922" checksum="D728EFBADF3E0610" modified="2018-07-18" version="1">MRIVIDCDKLIERKDLRRDVMRKREKTKQCHPIPPTPPPPFKQTFLQTLLQFKILKFGTFTLKSGRQSPYFFNAGLFNTGTLLTSLGAAYANTIHTSTNLPPFDVIFGPAYKGIPLATVALAKLYELAPERYGDVGYAFDRKEVKDHGEGGRMVGMELKGKRVLVVDDVITAGTAIRGAVSDIAEAGGTVVGIVGSAIMEVKKEMGVEVLAILTLDDLIVGVTDEGDRERMLEYRRKYRAIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLH2</accession>
    <name>A0A2T6ZLH2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_940154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000192">
        <property type="protein sequence ID" value="PUU76306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLH2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLH2"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="16775" checksum="EE67E6683E93367B" modified="2018-07-18" version="1" fragment="single">GQKDVVKMLLERDDVNPDSVRQGDGMTTLIWAVEGNHIEVVQLLLSQQSLDPNIPDNLGQTPLHWAVIKNHKEVTELLLGRKDLNPNMHDGLGETPLIKAVSLDRREITKCLLNRRDVAPYLRDGAGNTPLMFAIVEEREEIARLLLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLV0</accession>
    <name>A0A2T6ZLV0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_990554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000188">
        <property type="protein sequence ID" value="PUU76461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLV0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLV0"/>
    <dbReference type="OrthoDB" id="4507199at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="584" mass="65566" checksum="2095BDFE8A034E0A" modified="2018-07-18" version="1">MDIGVPSVRNLFRIKAERRILWIAIGITSIPLHLLYNSAVYTSLAANDFFVTFVASNHFELGAYSNTTEAPFQFRETLRNATTGKQYGDIGYQTDSHIIQQFTSILEGYNVSTTSYEGLTPSQCAKFYNTNFVSKRRNLFLITNYTSPAKFNNTFLKLTIVRGKEVSPTTWMCPDSLLQSGRCDTGKLTSMVANGLPWLVTLSTGEEVEVSRCRSEITDERCKVQFSLGIMIAVICCNLVKACAMIMTVVRSREPTLVTLGDAVDSFLRISDPTTRGICFADRWFIDREWRRGLGTGPRQWKQNRAQRWWTSVSKTRWITCNFCFAIIMIVAAVLLRLGIRNDGTVLNTDLKSMWSRGFGEVNSISLLIIRFRNITESVLLANLPQTILSFLYLTYNSLFTCMLAGHEWSLFGHHHRTLRVTSPRPGQRSTYWLQIPYTYAIPLMTLSGLLHWLTSQSIFLARVEIFDPFGRESLNTISTVGYSCIAIISVLTLGFLALVAAAGMGYKRFSAEITTVGCCSAAISAACHAWGVDLGEIVGKKVRWGDVGCVPNHGMRHLTFSSENEIRKPMFGEVYSGTEIEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLV2</accession>
    <name>A0A2T6ZLV2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1149417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000188">
        <property type="protein sequence ID" value="PUU76465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLV2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLV2"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="65"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="682" mass="75639" checksum="075AFAF3B70B7045" modified="2018-07-18" version="1">MSNRRTKLQKRTMESQGGDNYDRGQGGGGESKPSLIELLPLGSEFTREQQKSFSSAWKPVWYTGWHTGVLACATSVIVVLFINVGLTIYAATNPEYKMERGIGTLYSGSCDKSRKIGLWLHLGINVLSTLLLSGSNYTQQCLAAPTRSEIDAAHAKRHWMDIGVPSIRNLFQIKAERTFLWIAIGITSIPLHLLSVSITMPTQALANRKASALVSNNHFEPGAYSNIAEVDYSFQGISRNTTTGKQYGEPGYETDSNDIQLFGLMLEGSNANTPSYEDLTPSLCAKLYNTDFMSSHRNLFLITDYTPNATYNNTLLDIERVTSDKPSLGYWMCSYFSHSWSGCDENKLASDLASGHPWLATIRRGEEVEITGCKSEIAKEKCKVQFSLGIMVVIICCNLVKACSMILAFARSREPTLVTLGDAVDSFLRIPDPTTMGICFADRRFIDREWRHGRRTGPETMEAKGGFQNITESVLLANLPQTILSFLYLTYNSIFTCMVSGHEWSLFSHHHRTLRVTSPRPGQRYTYWLQIPYTYAIPLMTLSGLFHWLTSQSIFLARVEIFEPFGRVISVTISTVGYSCIAIISVLSLGILALIMAAGMGYKRFAAEIATVGNCSAAISAACHVWGEDSEGIIGKRVRWGDVGIVPTLGVRHLTFASEEEVQKPLFGEVYSGTGREESNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLV3</accession>
    <name>A0A2T6ZLV3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1129690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLV3"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="32552" checksum="2F715DCA68852C44" modified="2018-07-18" version="1">MAKSFADNINSFNVSNVSSVSNVSNVLNVSNHYTAAEDRSEILTWLSPLEPRIRHQDLRTRRADKVGEWLLRTDEFQRWCDGSQHVESEHATLFCCGGPAWTGYATKVKEQNTAVACFYVDFAAREEQSPTNMLGSLLKQIVGGLEKIPDEIRETFQDYKKVIGGRGLRVPEIVDMLQTVTSLQPTFICVDALDECVERHRPEVLDSLKQILEKSPNTRIFLTGRQHIRGEIDKHLGGRAEILSIKPNYDDTVGYIRMRLSKDTSLHAMDNGLEAEIIKSITENMPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM32</accession>
    <name>A0A2T6ZM32_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_990193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000184">
        <property type="protein sequence ID" value="PUU76549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM32"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM32"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="415" mass="45733" checksum="9B14742217655CB1" modified="2018-07-18" version="1">MDTLRASSKKLLPMSLASSRPMIIPSKGPGLTREKQGTQRHAGIPPAVAALLAVTAIPPPGSRKQRVLREQKSALDIFVEPPTPAHPPPSFDDALEEEEEEENLALESVELSRDPSRDSTRSVLSVLLGPPDEEHYESSPLEKSPSDSQLSLRSSSSESVPSLDNDDESTLSWNSAYSSPFSRRFRGLSSPPEDSQDDHPLMWDSDDDVSDVPTLEPEIGFFSEDALKRITRRLNFKSNLTASIRVLKSAARSFSSISVSTPLIQPDDYLTRSILSITPQFTDEKRPAPTLDTPTPALRRYLNPTNPAPDMPCTGAIQMQTYHSNRPDLTENKHSSSSPSSTDSSSSPVTRPREVRENGDFLRVIVLEMNMRRGGKLADTAAGKARLVLPPRQPCRLRAVGDPGRWEAWVCVYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMH4</accession>
    <name>A0A2T6ZMH4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1102274</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMH4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015763308" description="Chitin-binding type-1 domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="212" mass="20811" checksum="336A4AB5C27ADC6C" modified="2018-07-18" version="1">MTRLSLFLVFGLVTSALAQNCGPTYGGQICEAGKCCSQYGWCDTSAAHCAPATCQKAYSGAGSSCAGTGGGGGGGGGTTTTNAGSYPSTVPSIDVCGAGSGGVSCPGAGPGGFYYRCCSRNGHCGPKNGEQAQSDYCGTGCQPGYGVCDQRPVPAAPPAPHGTASAAENCGPIVNKKCGGSLCCSGSNFCGTGTDFCGAANWCQVDWGTCHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN92</accession>
    <name>A0A2T6ZN92_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_205126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN92"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN92"/>
    <dbReference type="OrthoDB" id="5456761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="98947" checksum="0BC19138A513E6B4" modified="2018-07-18" version="1">MHILYRGFPDLVDKLPPEIGERLGPKPTLYVGSNIINALKFGKELEKHLGSHGQNGKFNEYGEAHVILVRDEETCSKLQAELGRSSLVLTILDSKGMEFEDVILYNFLSTSPYSHRLEILEELFKRRHHTDLSPDHLGPAREGENKKGRRQEGRARPESEQNKSAYQGGHADWVKDNIVLCSELKHLYVGVTRARSRLWILESNTSILGPVRRLFNETATLLLPRQYPSPILDILEEQHIGVSELYRRLSTGRKLSASQWREMGYQMIDDQKYSKALRCFEDAEDPHGVALANAYIIEQNGFTNRAQGSFELANLAFIKASELFLKAHSIAKAVQCRKEAGDPRGAVKILVDSGAYEDAARLSADVGLFLEAGEMYSNLDKHEKGLVGYARGKQFKPMFNYLKKFKSEIEPCCWKQYVLFGYLGEFGKSDMAPDDFEKQVLCLFGSPEEQAVVLLRFGLVKKLFELLSTDKKCMGAYETETEQGTQLNMVCEFLQAEHIATNPWPRTRGDGGIHNVLLRPVGRRSPQIDSFVKTWEDINRALNISTQRGTRVDIGEMGQMKIASYLDLLITRSAYPNNQCPPPLDCIERVLKDLRTVSLHEMIPYSAQLYCGIYEMPCRPGEYILMEWSPLRADSKMRLPLRPVNIGSLRRKILRHILQDIVPPFEGLRVIWGTMAEPQLLPSATLAETHFEKLDWLARVCQISAELSTIIKGIRKPKDSLLENWDSGFWKGVLLEQMEFRSSYEQSLEALYSIRSELKTQAGKHRILYPLLIKNDATKPRMESALRMDTWACVSSLLAQYQASLFLGYRDQWRSTILEMRNQMMARGNRSFKYGCEMITLVNQFMSETEAGDFPGRFVCVVQRPALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNF4</accession>
    <name>A0A2T6ZNF4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">B9Z19DRAFT_1102101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU77018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNF4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNF4"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="68"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="347" mass="38757" checksum="893F217C0F962B08" modified="2018-07-18" version="1">MAKKKGQRYRGREHHENRGPGERETQKLPFKARCWDLGHCDRKRCSGQKLMREGLIRSLPLDKKFNGVVITPTGKTVVSPTDKELMEKYGAAVIECSWARLADVPFHKIGGKCERLLPYLIAANTVNYGKPWRLNCAEALAACFVIGGHTDWAEQILGPFPYGKSFLEINGELLEKYAACADADDIKKVEIEWLDKLEKEYKESREEGGDPWVGGNSNFLPVSAPSSREATEEPAEPQNRSYEMPSSDEEDGGRYREYLRQKALQSKEFTNPKPTKVNKASKVDSEDGEATYSGGEDDLGQDESTFNANGADETKEPSIRHSHQKYPKTYTASFPSTNILVSGGLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNH9</accession>
    <name>A0A2T6ZNH9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNH9"/>
    <dbReference type="OrthoDB" id="5337062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="7942" checksum="472217E1F61875EE" modified="2018-07-18" version="1">MSTTTPMTSPPTSQKDQQPPKDTKEVHQKALADIEEEQSTLREEIARKLAEKATLQAVHDSLRKRGEDGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP75</accession>
    <name>A0A2T6ZP75_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP75"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="101" mass="11524" checksum="F85B3BE5E3048CB3" modified="2018-07-18" version="1">MSELSSAWQDFLLYYAVPLTTIGAAIILVMEHRIRPRPIKVIMEPNDHDLRCGCRTELVQIRSQLDDLEIHMARHDADFEGMPYQGAPDRTHIPGAVVKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPT9</accession>
    <name>A0A2T6ZPT9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPT9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="115" mass="12724" checksum="116DD1C450E9695B" modified="2018-07-18" version="1">MKGNFTNLYVKNSDPEDLDKGILKLNPGPMIAAGSMIITSSPWGRTIAEMNERYNVRKGDAVREEMCILRQAPDEDLRRQKETLEARILQKKLDKMEEAEKAAAGSSPAGKSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ08</accession>
    <name>A0A2T6ZQ08_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_986409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ08"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015402459" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU77573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="36345" checksum="2F488B044DD7DEFB" modified="2018-07-18" version="1">MLGLASLLTFVSLVTAAPTAPVYSSCTVNSTSDLATAKKTCTSISIGSFTVPAGQTLDMKGLLSGTTVTFTGIVSFGYKEWIGPLVTVSGTNVKIVGAPGSCLDGGGARWWDGQGGNGGKKKPKFFAAHGLDSSSITGITLKNTPVQGFSISSAEGLVLSGITIDNKDGDNNELGHNTDAFDVGNSDDVTITGSTIYNQDDCLAVNSGTNIQFLNNYCSGGHGISIGSVGGRSNNVVDTVTVKDCTIVNSENGIRIKTVAGATGSVKGVTYSGITLKNIAKNGIVIQQDYQNGSPTGVPTDGVPITGLTIANVKGSVASSARGIYILCAAGACSDWKWSGVSISGGKNNCTGAPSSVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ71</accession>
    <name>A0A2T6ZQ71_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1085875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ71"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ71"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="322"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="445" mass="49109" checksum="33CA95B8C7634812" modified="2018-07-18" version="1">MGSNSKTKMDIDSDPDSDSIETTSVLLGYAETESTGDTSSHLGGEPTWLHPNSPPDARLAKCEHCKKMMSLILQLNGEIPESPHARMLYLFACRTKTCRRRKNYAKVLRAVMRSTEVPEGPEVPVNAPKKEEFPELEKQKKVGAVQHGDFLFGGSSKPAAGLNPFSMGSTASNSNPFSTMSTTSTTNNATPFSSYTTTSNPLSSPPAQQSPPRAPQTDTNSLTKSFAETLKFTEGGLPSHETGDIRYFGPAEPWPEKLPYRYPLFHLDAEYEAIEKTTGLKAHQLKKYERLMSQAEEDGDDEKEGGKSGQDSNTPSSDQIDDDVFQRFADRIANNPEQVLRYERGGTPLFYAVSDEVGRLLNPNDGGFLATRIPKCGNCGGSTRVFEFQITPHAIAVLEGDEEGFDGMDWGTIMAFTCKCVPKVLDRNRVGYVEEYVSVQWEKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRW4</accession>
    <name>A0A2T6ZRW4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRW4"/>
    <dbReference type="OrthoDB" id="5417803at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20609" checksum="414EE39F7B6D8495" modified="2018-07-18" version="1">MFSFFKRLKDGLSQGFQRLRTVCQNSPVNPIWALKASVKAAGPLRVVSRSSRAIVPVTLTLSAIQILLAENKMDQFANEVCTLALGAAGAAIGSSIGVVGGLPGMIIGAGVGSFLGGILGDWVHGKIKEWLFTEGKDGVRPIDKIADKFRAATDTLRVVSEVIAIVMRGQAEVFAALLQHWRRTGGLGGGPGVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSC7</accession>
    <name>A0A2T6ZSC7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000120">
        <property type="protein sequence ID" value="PUU78391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSC7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSC7"/>
    <dbReference type="OrthoDB" id="5379778at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24637" checksum="99114CEA31E50AC2" modified="2018-07-18" version="1">MSQAEKAIQKPGRHEVDVSKRGAVIALREAGHKLKEIQSITNIPRSTIAGIIKHVQNLSKDEKENCDPSYPGPRLNNTVLNPLPPPGRLRKFSDEDYQTVVEYATRNRAQRHKSFAQLAKELPFSIHRTQVAIILKKQGYSLHIPRTKPAVSKPNQSAQHGERGQVQLMEDGAGPHRAKHLNAYYHEKGINKVDWPAYFNKTGKEKEVAFAQIENIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSN6</accession>
    <name>A0A2T6ZSN6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_982994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSN6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSN6"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="1">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="17025" checksum="B5C5AE457C3C5F57" modified="2018-07-18" version="1">MATSADFIRLAQTLPPRLTRFFARYPPNTANDVVKNPFKPTIHPVTKKWHNPVYSLRRQKELVVLARDHGVEDLLPPTVKKTAVREKRALEGPKMRKMMSPKGHQWERTLKGRLEMREKAMRGMPKLIEKWRKAGHGRGWTQWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTG0</accession>
    <name>A0A2T6ZTG0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1083259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTG0"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="11">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="15808" checksum="7C5F01FE1A9D70B9" modified="2018-07-18" version="1">MIKAVAVVRGDSNVSGTVTFEQESENSPTTITYNITGNDPNALRGMHVHQFGDNTNGCTSAGPHFNPFDKTHGAPTDDERHVGDLGNIQTNAQGNAAGSLSDKLVKLIGPESILGRTIVVHGGTDDLGKGDTPDSKISGNAGPRSACGVIGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTW9</accession>
    <name>A0A2T6ZTW9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1140701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000103">
        <property type="protein sequence ID" value="PUU78937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTW9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTW9"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="252" mass="28467" checksum="869A58E43F4EF6AA" modified="2018-07-18" version="1">MSLQTLPNELLLDIAGHLSTPKDLSALTQTSKHFNLLFTPRLSTLSLQPHGYSKQVSHCLSAGQSPTYHYGNESRTPLHEALAHGYEVFSDGEKQWWIASRRAHNNLAFEDTVAVLIAAGVNLEARDGSGHTPLHTATVRGLKRLVRVLLALVVQVDAVDVNGFTPLWYARTYGYEEIVGLLVEAGAKEVTFSHSIWVRWLPPRLDTGLVFSGEEEEGEGEEEEEEEEEEEAEERRLGWSRVDRRRLWGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU46</accession>
    <name>A0A2T6ZU46_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU46"/>
    <dbReference type="OrthoDB" id="3886845at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="104" mass="11060" checksum="B15820F49070535C" modified="2018-07-18" version="1">MANSSPVGSEPTRYLELRISRRYSDSGTGERPLFLGASVKFALREAVKASRASAAVDAQAMGVVQVDSPAMAERSRVAVGDWIVQGAKVGAQEGEKRFFVEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU82</accession>
    <name>A0A2T6ZU82_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU82"/>
    <dbReference type="OrthoDB" id="4233498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015562109" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="18974" checksum="A7C2753F23DCFFCE" modified="2018-07-18" version="1">MFSLKNLIFQLLVLAIIAALTNCSPSDRLSGGVSRRSELATDNAVPASASSGNINVLNKAQFEASGLTLITPGPVADNPNGNVRCETSNASPSTSNARGLANWFSNFFGWYCCNWNVNGGGCSHMMTVGDASTAMCGNQGCIVCEDVYSNIYRIVEFCQRDGKVGGVSFLDQGSHLVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV37</accession>
    <name>A0A2T6ZV37_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV37"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV37"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="400" mass="45788" checksum="3536DFAD5BCA86DE" modified="2018-07-18" version="1">MDKLPLETARHIVSYLTKRTDVASLRLVSRTFAILGAELLFHTISFHPSYPSLSRLREISQRPHLAHNIRELVLDLPPIRDLIWGPFVRHLEAEGIDISSNTKRIPEAFRLLTYHVDQYSKLQTSGDFASMLREAVRGLPRLRGVLMKENNERDRDYWLSQSSLTLGCNGGFNYRIELSAELHGYSGSKDHYRAFAALVDAVYYAGCKLDTFYVDAKVDPRMFFDNTVRLERAGAVFQNCRVLGLKMDIEDSMVEHLIKAPLFNVILPSSPNLQSLTLQFGISCAREAIPLSTIFGSKHVWPRLQKVSFSFIDMEDQELYAFLLRHKGTLRELSFSMCSLYAGRWDDAMMFLRQNLGLVALRLDPLFELAGEFDYLCESELKMMEDYVVNGGKCLPPRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW27</accession>
    <name>A0A2T6ZW27_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1064035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW27"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW27"/>
    <dbReference type="OrthoDB" id="5418922at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="209" mass="22530" checksum="514DAB9C83317212" modified="2018-07-18" version="1">MSIQSTSIPGSAHNQQTTLIPSQLGVMEAARAVWDLVGEEHINDFAVVGGAALLFHGSDIKTEDTDLAITGKPFDKFCQLVKNDSRFVEDPYGGPWRYHATFGFDVLIDFLDKLGGGGYLPEMTGHCLIDGVPVATLVDLALLKGAAWVDRDEKKDLAGFDYALRRMAEAGLSFRGSGEIGKGILDKVVVKLQSSEKGKRVLGMITSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWK7</accession>
    <name>A0A2T6ZWK7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_977489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000080">
        <property type="protein sequence ID" value="PUU79856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWK7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWK7"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38152" checksum="B7359D79887C2EB1" modified="2018-07-18" version="1">MAPLTRGQAKGALWFDGTEREQRASPEGQESSDSDFTDGEDGPPREGGNTDNQKPTVERLKGKLIPNGEEIGERLMNLIKRDRKGLQKIYGETEAELDKNLRAPIKRGEEMARKLITEMGCGYYIATDLTVLTLYDVVILIDDSDSMAYEENGARKETVIQFIDYITEICSMANESDILAMRFTKRAGGQKKSPGKSQEYLGHHRYSRMAGIGAGLKEILDEFVIGNPNQNKPLLVLTVTDGAGQKKGHLKNVIRDCVNERAGAGKGFDAVSFQFSRIGNDPGAAQLLIDLDQDPEIGEYIDVLPVEFDLPGQLEDKWFVLPKVLIGAILPDAMPPLPQLSSPSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXL8</accession>
    <name>A0A2T6ZXL8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXL8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXL8"/>
    <dbReference type="OrthoDB" id="5421421at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23219" checksum="CDA79A2640A79DB2" modified="2018-07-18" version="1">MEKECFMEGHSDGDVLGKHTSDSTHLANPTPPTSPTTAVSKKRSQSPTSSSSSSSACSLQPPPPKRRVLLPSLSEETDLLLTLKDTQNLPWPRVHAAFAAHGWERKLTVLKGRYKAIKEGGVYWEEDDVDLLFRAVWEVEKEFERGRWEAVAEKVKSWGGCGGRVGSGECERRWKKGRRVEKEGEGGKVEEEGKGKGKENVMKVESVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXZ6</accession>
    <name>A0A2T6ZXZ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1063549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXZ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXZ6"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="358" mass="39158" checksum="6D56341B8FED4C76" modified="2018-07-18" version="1">MAIPYYLADLFTDSDTDTDTEGVYLNENGVGFKAMHKPTWSPDEILYEEPIDYLKCEKCGVKFLNVEDGHPLGGNSENDPGRHFYCGKCRVDSKGEEELKEYMVESSEDVVCRECSQKFHIPEALELHCKQVHKPKPITTHQCPGCDALFNAISGITQHIESGQCTGNLSPSGFRKLINYENTPLAKKDLPADILAGSTTTHTWRAGILPGRVKAALAGTSNGFKPEELVPKDFVSVLDYTLPSEPTNSPTENLADCWNKILGAYLCPRLRCGKKFATVTALRAHLESITHDKKAFRCPTCVECFVSSSALLQHAESGACGIKRSPAYNQLIKGATGGLVSVAEKSGLKTGWQKPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYI8</accession>
    <name>A0A2T6ZYI8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_974532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYI8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYI8"/>
    <dbReference type="OrthoDB" id="5283210at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="61" mass="6764" checksum="BC2AF47A8D2DBCB7" modified="2018-07-18" version="1">MDQDPSYRPKLFHSSGPLIGTEMEFPAANNILKKCRSVSAAQQIVGLFAPKMSGGVWRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYT5</accession>
    <name>A0A2T6ZYT5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1078910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYT5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYT5"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="97" mass="11038" checksum="155E8548E9DE3322" modified="2018-07-18" version="1">MTKGTSSFGKRHNKSHTLCRRCGRRSFHIQKHTCACCGYPAAKVRKYNWSEKAKRRKTTGTGRMRYLKTVTRRFSNGFRVGTPKGARGPQSNADTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYT9</accession>
    <name>A0A2T6ZYT9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Muts domain V-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1123261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYT9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYT9"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="27546" checksum="B54F405FCBAA32A4" modified="2018-07-18" version="1">MDDGIEANASTFASEMRETAFILGNVERGSLIIMDELGRGTSTRDGLALAVAVCEALIESRALVWFATHFKDLARILAGRAGVVNLHLRVQMEDENTMTMLYKVTDGAVEDKNYGLTLARLVGLPQSVLDRATAVSEMLVRRLERNKRKLEATNLARRRNLVLTLKETLIRARDGNMGDSALRPWLSRLQDEFVNRMATWDAEEMRAPVATTEDGQHSEQAGVGGKRMEDIIEIGSDGSDDDGAGADDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A059</accession>
    <name>A0A2T7A059_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A059"/>
    <dbReference type="STRING" id="42251.A0A2T7A059"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="358" mass="38336" checksum="DC142AFBAA8B5838" modified="2018-07-18" version="1">MDAGGPSTAAGSYNAGSPSESSATTIHPSQTIRTNTDKIEILYDCLLTMLTEDWEARWDAAIKLNAVINREKKKEKGKGKEKEDGNIFTPTITDAAPNAAQVPTQHVAHQTPLRPLGIVGRPPPSPNMRRKITTADEVNTPHASPCEVLQSSRRRSMRIIGSAQKPENDKFAVIATAQEEEFALTSPAEGTVQGFRSQMASKTEAKARDERGKYVKTESTILKPRAGAGVMKRTAVTSFRSGIVEKAKAKGGMEKGTDSQSIIPTTAIEEAMEPPFTETSPEVLHGQRRRSMRIIESIEKSAQEKGESTAAGLAKGKEIVGGGSRGKIAVEVAINVESPILKPKAGAGISKRRVGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0I9</accession>
    <name>A0A2T7A0I9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0I9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015736876" evidence="1">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="75" mass="8769" checksum="F22BB5033C971748" modified="2018-07-18" version="1">MRHQNFFIFHFFQCVVGAYRGLIRAQSLYLQSLVRVMMYDSGFVFFALYDDDASWKHTRPLALGSEVFAARGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0M2</accession>
    <name>A0A2T7A0M2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_972074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0M2"/>
    <dbReference type="STRING" id="42251.A0A2T7A0M2"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="174"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="672" mass="74206" checksum="B44243D29BDD83D9" modified="2018-07-18" version="1">MTTPRSGSREFQPPIPPPAPPAPTDSVGGLSATDDDADGDVTRSPVDDELEWKWILNLSMHFRDQSDREKFFVTFAETPTLRRRLTVSCDYRDAEEGTLERELATLKYQRDKSAKIYDAIRDSLSDIQFYDTITNLKLQTSDGRLHVHVTEDLHEIIPYPPVIAIAHLSCPKYKESELEFDSHLSGFVYKVKINGDVFIKKEIPGPDTVDEFLYEINALYALADSNNVIRFGGCVVDEDRKKVKGLLISFASKGALIDIIYHERGRLSWETREKWAKQIVSGLSEVHEAGYVQGDFTLSNIVIDDNDDAKIIDINRRGCPVGWEPPEVTAMIDGLQRIGMYIGVKSDIFQLGMVLWGIAHEMDEPEAVKRPLGMGEAPGDVPDYFRAIVEACLSERPQGRPSAKDLLSSFPELNQPSRRYIGEMPHHEEGGGSYAALDERDYFPNGFPMRLGQPYEEAPGESGGQSMSEVSGVNGTDELLLNGQLSRNSGSTYTPFPPQELSNHMTGSRRPLVDEETQSTASNGNRPISRDSFEDAPQVIEAAPSEASGEEPYMPNNIESVIGLLPASLPPPPPPPPFVRPPLERYSTANDHFGDESDWSPRYMPSSASQPRRLPSPPSWRSGHVRGISMNEDYAGRDPQGTESPGNSPISPTSPPPPLPLPIPTAGPGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A179</accession>
    <name>A0A2T7A179_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_971595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A179"/>
    <dbReference type="STRING" id="42251.A0A2T7A179"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="61193" checksum="4805014377DB17AF" modified="2018-07-18" version="1">MGIFMLLIDYAEDKKFHDYPLIPTTLALLSLALFLFLKKERSIHSPTKFPIAGIESSGYFGLVKVRGRFVSDALQIVKNGYYKYRGKNFVVTTYTFDRVILTHDQVKEISNAPEDIVSARAATNETLMGSYTGLDRFPPTNYIQDAVRIKLTQNLGTIKDAMIEEMRSALDTELPECTTDEWRSVEIFPPLRRTIARTSSRVFVGLPLCRNEDWLDISMKFTRDFFMTIHILSVIPKLLRPLYAWMFNSGKVLTSYKKRAGILLAPTIQRRLEEEKLAEQNGAVYEKPNDMLQWLTDLAEPHHKNIESLSEMQLLTILASIHTTTNFLLNTLYDLAAHREYIQPIREEMEAVISANEGVLDKVALRKMRKTDSFFKESMRKNTFLINFNRMIMKNLTLSDGTRLPKGALVSAPILMFSTDPDFVEDPETFDGFRWYKKSLEAEGLATHNTNWTTTSSNNLIWGHGKHACPGRFFAGEMMKTLLTFIILQYDFKYPEGQSRPDGFRRAEFTIPDITRKLLFKKLPGPKKFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A199</accession>
    <name>A0A2T7A199_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquinol-cytochrome C chaperone-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1077087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A199"/>
    <dbReference type="STRING" id="42251.A0A2T7A199"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="133"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="305" mass="34512" checksum="CE209EDAB507AA44" modified="2018-07-18" version="1">MALRGICSTCLRVSSGLTATRRALPRSLPLIPTSRLHTSQRNIQQTTTTNKEVFNVGHIAPQVNGPASPGETKLIRGIFGKVAEKLREKMPNTTEPYVAHGVTLKLYNECLKQAAYTDGHELSESARFWYNVCDRPKTFMSWAQVTVLHIWMLIVRIRAFEPNRVKSWQQHFVDHFFYDAEGKMIHTYKIASGGQRKGYLKDLYSQYRGMIAGYDEGLCKGDAVLAAAIWRNVFDARPDVDMEVLATITSYARRVVHGLDRVDDQVLYSARVTFGLPNEEAEIVRVESKFIETLLETPDVNNKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1E0</accession>
    <name>A0A2T7A1E0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1076757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1E0"/>
    <dbReference type="OrthoDB" id="5596992at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife RNA repair protein HAD" evidence="2">
        <location>
            <begin position="113"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="571" mass="63950" checksum="833B786184C87504" modified="2018-07-18" version="1">MSYIPHTLLNLLARLYPSSKASLSSLFTAPPTTPPAFLSQLFRLPLAPTAMYPSNNRPGGYSSSGAYEITPMRPTEHSPTWLEKWSAQDRPLPEKTAIKAIHVYDFDNTLFKSPLPNAKIWHTSTLGHLMNQDFFKSGGWWHDSRILAATGAGVEAEEPRGWEGWWNQQVVSLVELSMQQKDALTVLLTGRSVAGFAPLIKRMVASKKLDFDIIALKPQRGPAGENIKSTFYFKSMFLNDLLNIYSHADEVKVYEDREKHVKGFQKFLKDYNRINCQNNVPRIGLTADVIHIVEESTLLDPVAEVREVLKMVEEHNHIVPGGTGRLVINKTVNYTGYLLAPATTSRLLNTLNIPGLGRNHKDIRLNGTGIMISPRAADSQVLINAGPLGTVVEFVVTGWGHFENKVWAALVRPVDPNFKVYSALDSHRPVIVLAIRRDGKPSDAQKITTWQQVPTGNFVVKTMIAEKAYLRVEDEGYQPEEKPSPHPSRRGNFQGRHVPYNQFGSNRSRGGRGRGRGYGASNASRKGANPEHRQESRPADKNGGYHAYERHQQGARPVEPQDMQFLSEMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1E4</accession>
    <name>A0A2T7A1E4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1E4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10964" checksum="CE528202645AC647" modified="2018-07-18" version="1">MVLSVAQYSSQGVLFYLFFLEKGFLASGDDCDVYKFFFDKISCYYTVRYTCHTMPWHCTFFFCPQARASTATCNTNHQTYHTLKWTSARVGSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1K3</accession>
    <name>A0A2T7A1K3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1190936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1K3"/>
    <dbReference type="OrthoDB" id="5274873at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18214" checksum="27FB5494C9320E4C" modified="2018-07-18" version="1">MYYILYLSSKPSPPPQYLTLTYIRLCRRRRWSDPHYECQYLPSGISCIVRVNNREYQSEGLVESEVLAREAAAMRAYLLCRNFSVTDGAHPGTNALGSGNGTSPPSQQAASSLAGGLTPPHRGYPVPGAGNTYITGSLPGQGNLPMNNGSSGRMVTSQGVVIVGHPQVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1P3</accession>
    <name>A0A2T7A1P3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1076672</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1P3"/>
    <dbReference type="STRING" id="42251.A0A2T7A1P3"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="279"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="462"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="571" mass="62940" checksum="650DE37AEBAD1F7A" modified="2018-07-18" version="1">MTSSKPRNSLSLSEQLALLENPAPTDFDPEAPEEDYNHSEKSEGGRDEEENEEDLGRAHYITVGKSRLRKGNPVLLDPKYNGARVSRQKLYQDEDEDHQMNGSDDDSEGGDGNRSEDDADEKKAGGPENGEIPTDEDDDIDSDDALGSNEDRFSGFKFLGSSTTKEGVNATRGMKVVDGSSSDGESGTDPDDEAILNEEKDSNEDDASDVESNLLSHTDDDEENESEGESEDEEGEDSLDESGEGVQDVEARRREELKKLITEEQRNVVANISKAVKADTEKGTAVKQQQKTFDSLLGVRIKLQKAIVATNSLPAPSQPPPSPRPASETYQAAEDAALNLWSTLTDLRCELSSPSALKRKHDDTDTSTPTLWAKMQKLEGEVHPSRLSILDKWSTKTFSVSTVTLAHKLNNSVQRGLAATINETLMTDLNRHVQKTRVPRSCAPTKVGNGEDAEVYDDSDFYQMLLKALVDQRMVDNANPGGASGAIRWTTALRDAKVKKAVDTKASKGRKLKYQVQEKLQNFLAPIANNSWSEHQIDELFGSLLGQRVRVDEDSENEEEVEFDGLRLFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1U2</accession>
    <name>A0A2T7A1U2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_572551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1U2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="14173" checksum="07E2AF777C2F6936" modified="2018-07-18" version="1">MFEFGLTTITLFSLLSLLFLILSASLIIKLIHPSIRYLSIDQSSAQVAPRTLRLRYYRPCHTKPNRRRGEKKRNYENHKDYTPLLMDGDDDADRLPRLPPDGTESPNYRMMPQEAMQDKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1X8</accession>
    <name>A0A2T7A1X8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_574158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1X8"/>
    <dbReference type="STRING" id="42251.A0A2T7A1X8"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="133" mass="14157" checksum="7D40C8BCAF5A047A" modified="2018-07-18" version="1">MSSDKGLLRPGHAFVPPSTDISTSSTNALSGVPAIDLPEFAAEPIKSDTIVGHDALTLLPEVQATGRPAGSRRPFQRRRRSRACDACRTRKTKCDTPDEGPCSACVAASLVCKFSEGEDKRRAGPARYAFGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A262</accession>
    <name>A0A2T7A262_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1121592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A262"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015514186" evidence="2">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11484" checksum="73DE6070C55839DE" modified="2018-07-18" version="1">MHHFGPWWTYAPPIRAKLTLPFSLFHILPANDDDAPPPPPPTAGPPSPTELPDNPFLPSIAKNFSQPALRPLRHKPLIRCGKRAHAYRVHPLSRFLCSGSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2C0</accession>
    <name>A0A2T7A2C0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1106186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2C0"/>
    <dbReference type="STRING" id="42251.A0A2T7A2C0"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="492" mass="54748" checksum="8ADC59E50A735A7F" modified="2018-07-18" version="1">MYEAQSDLIVWYRLETEFFQDHLSHTKYVGKAKNRNEKVEEEWRNCGELGRGGFGVVYKQIQETTGHYRAVKKIDKRLYPRFDYSRELLVMAILAKRPSLFVEFLGWFEEPETLYIAMEYLEEGDLTKHIGTPLPQETVQNISKQILEGLKVMHQQGIAHRDLKPANIFVVSMSPVWVKLGDFGVSRRILAQSLTTFHTQVATPVYSAPEVLGLDSNSETSDYTHSVDIWSLGCVIYELLVGTKLFISESQVSRYYFGKFPFPEDTLKGLSPPIDDLGISLIRSVLMIQPEDRPTAADALGHGWLAGPKSGKGSGRGNEDKAIQSRGGSSQSKERENRPATYNRSKKRSRRTSLTQDGTSSILLDVASVANAGSQMGAGPPPPESMLGTPMMTPLDAASAEGAVVQMGPRASESVLQNFRATYSKSPMVPRNQVRDIPQTYQQGNISNTKFILLMNCVADKNWLLNPRQPANDPNPYPRNSLQSTPSANGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2F3</accession>
    <name>A0A2T7A2F3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1190852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2F3"/>
    <dbReference type="STRING" id="42251.A0A2T7A2F3"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="568"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="606"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="260"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="792" mass="87305" checksum="0FC228959CE06202" modified="2018-07-18" version="1">MSQPFKVVIVGGGVGGLALALTLAKAGIDYVLLEAYPEIAPDAGASIAIGAGGARTLDQIGGVLEDLLAISTPLGGLCARDDKGKPMYDYNLLRSIDRHGYQVGFLPRQDLLALFYKHVPEKSKILPGKRVVKVIHSDTGVRVITKDGEEFAGDIVVGVDGVHSVIRQEMWALADELSPGLISDKEKQDTLSAEYCTVVGLATPHPGLEDDYGHILHNYGRSGGVITGYGGRIFWFLFEKLDKVYKLPNIPKFTVEDGRKLAEKRLEDAVTEDVKFGELWDRTTSYVTVPMEEGCFEHWHYKRMIVIGDAAHKFTINLGLGANAAIESAAALTNGLYHALKAHPEGLSTEMIDKVFKDVQAHRKYAIEFTDGITAESTRMQAWATKTMELTTKYIVKNLIGEDYLWDLQGDIPTRTERLDFLPDSDKGAIPMVYSPRYPNKRAKLITGIAYTLPAFALLGCYLGVRSSALIPAEVNEKISRVAAETGIPSFGIYSSGRFGLAKIFTSCFSSLWDSLTDGSDKQLDYRLKIVAAQTALGLFPILTIMIVESLRRGNTMTLSKIPTFWGFLYQIFPISIVLPVYFFFHAYQITPAKYYEKNFISIPMAYAKSLIPTLIISFLIPTSITLFREQSLRASIALWLPFPIYAAIVHQILKLFFTTPAFPKKNADLPYTRGAYLLSFGVSALAHLYALYIAITTGDSFSITARLAPGTPPTHNSFVETGLDIVRSEHLVAFAAGLAWVLILLNDMKRFRKTAAGWLELLGYITAASVIFGPAATVLAAYAWREELLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2P1</accession>
    <name>A0A2T7A2P1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_969694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU82006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2P1"/>
    <dbReference type="STRING" id="42251.A0A2T7A2P1"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF158">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 12-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU82006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="531" mass="57528" checksum="B36A888930B16FD4" modified="2018-07-18" version="1">MPDRYLRIARFLSLAAATCISLACGTNYVYSAYAPQLATRLHLTATESNLIGTFGNLGMYLAGIPSGILVDSKGPRLPVLIGAASLLIGYYPIYLAMEGGKGSANVFALCFFSALTGVGGCYSFNGAIKVAAVNFPQNRGTATALPLAAFGLSAFFFSFISSWLFPGNTSDFLLVLCLATSGMIFISFFFLRIIPVPTTYSAIPPRDMPESSRLRRTKSNEGRRSPAMSSYVEPGTSTISPDTTVVVANPDPMPDEGSSFLTKSSSSGGSEEYRVDAESNHGQVIGNSDIHHDHHIDIRGWALVRKAEFWILFFLLGLLTATGLMTINNIGHSVQALWTKFAPDKPPDYVQGQQSMHVSILSLCNFSGRMLSGVSSDIMYRKYGLQRLWLIVASASIFSLAQLCAVTVENPNWLWLVSSLSGLGYGVMFGVYPTIISEEFGLRGLSQNWGTMTLSAVILGQIFNIFYGRVYDHHSIITPEGSRECNVGLECYRNSYWITLGAVLLALAATLGAIKRHRGRSGYASISTHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3C4</accession>
    <name>A0A2T7A3C4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3C4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="256" mass="29052" checksum="455214BB185FFF76" modified="2018-07-18" version="1">MLFENLTQIMNEHFENNVAPPSSLPSSPPISPKPSTPNNSTSSPLSEQSTEIDTPIIERDPSPIPTPAQWRRVKEVQEAAKVLTDISHPMKHLTLNQTPDPYLAAQSVQNTLWSHTPVVTASRLTRLWTYLDAITLNLYSDQSAMQMEDFITTLSAVEWAEGDSNPETCDASTFNSGHAYITQTYLQFTELLKRHTTMRGKMFLENVRNVAPRLYIGSYNNLRLVAKKHFPDEDVIYRSPYPVDSWRVLLVCVLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4D4</accession>
    <name>A0A2T7A4D4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">biotin synthase</fullName>
            <ecNumber evidence="3">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1074440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="14">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4D4"/>
    <dbReference type="STRING" id="42251.A0A2T7A4D4"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="48"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001619-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU82584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="321" mass="35083" checksum="2A89591A3C15D826" modified="2018-07-18" version="1" fragment="single">GKTLFEGALNALPKNTWTKDEISSIYNTPLMELTHAAATLRRKNHPHNTVQTCTLLSIKTGGCTEDCSYCAQSSRYSTGLTAMKLSTLETVMAAAREAKANGTWRDMSGRTRGLERIKDMVREVRGLGMEVCVTLGILDSKAAEELKGAGLTAYNQNLDTSREFYPKVITTWGSDERLQTIENVRNAGISVCTGGILGLGETAEDHVSFLHTLSTLPEHPNSVPINALVFLRVVATARILMPGSIVRLAVGRINLTEEQQVLAFFAGANAVFTGERMLTTECSRFEANRRLFEKWGLANEGAEVVAEVSRSGKVEEVIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4N9</accession>
    <name>A0A2T7A4N9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1120301</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4N9"/>
    <dbReference type="STRING" id="42251.A0A2T7A4N9"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="17">
        <location>
            <begin position="84"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="18">
        <location>
            <begin position="513"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU82713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="989" mass="111351" checksum="B4D6BFF0609D892D" modified="2018-07-18" version="1">MASFKRSLTDSRESSELSSKVFLRSSKGKCTKIVRELYLRRDIPCSSKLCTRCLADIKGDSYGRTKPFVLSSNPPVNDTIKAPHYIVPDTNIFLHCMDVLEHAAITDVIVLQTVLDEVRARSLPLYNRLRGLVASGDKRFYVFHNEFRSETYVRREPEETINDRNDRAVRRGVQWYHEHLKEVTRGSGVSIAVVMVSNDRGNLEKGKREGVVCCSIKDYASGMKNSAELLDMISAALEDENAKVAKGDLLYPEYYSMSKMMTGVKAGTLHQGKFNISPYNFLEGSIHVPSFDRPLLILGRENINRSVHGDQVVVRILSKDQWKRPSSKIIEEEAMTKNDNPDVEQFEAIETEQERKALIDEAKVSQSAIGEGNPQPTARVVGIIKRNWRYYVGHLDPSSASSVGGRSQRNVFLIPMDKKVPKIRLRTRQASELLGKRIVVSIDAWDRTSRYPTGHFVRSLGEVESKEAETEALLLEWDVQYRPFPKAVLDCLPKEGHEWRVPQDPEDPRLHQRADYRGLLVCSIDPPGCQDIDDALHASCMPNGNYEVGVHIADVTHFVKPNTAMDDEASVRGTTVYLVDKRIDMLPMLLGTDLCSLKPYVERFAFSVIWEITENGDVVSTKFSKSIIKSREAFSYEQAQLRIDDGSQNDELTQGMRTLLMLSKKLRQKRMDAGALNLASPEVKIESESETSDPIDVKTKKMLETNSLVEEFMLLANISVAGKIYEAFPQTAMLRRHGAPPASNFEELQNQLKVTRGLTLRTDSSKALADSLDQCVVPSNPFFNTLVRILATRCMISAEYFCSGTQGYPEFRHYGLASEIYTHFTSPIRRYADVVAHRQLAAAIGYESLHPTLHSKAKLEGVCGNINNRHRNAQMAGRASVEYYVGQALRGKVIEEEGYLMRIFSNGFVVFVPRFGVEGLIRVRDLAAVEPKSEFDADNYTLKVEASTGSWSVGLFDQVAVKVMDDVEERTGKRKIKMTLVSVKGRKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5K1</accession>
    <name>A0A2T7A5K1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU82988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5K1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="17608" checksum="192E3BF276B76D5F" modified="2018-07-18" version="1">MASPTSTAATPLLPASELEAKHYYHGLPSRPVLVARTGKDTWKLPTGPWAYLRDKELRPVGDHLLKEVWDNHLIAPILNILKSKEVKWTSIDVVRIGFADESVAPVVVWIGVKPDTLSREDGFAVANECKQLLVAKKIHDVEVEIRESIVTRLVKITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A683</accession>
    <name>A0A2T7A683_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1189848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A683"/>
    <dbReference type="STRING" id="42251.A0A2T7A683"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="356" mass="37551" checksum="AA11E3DDA6C14875" modified="2018-07-18" version="1">MSAPPPPNYAGSPPAGGNYYSPPPEKSPYGPGGQTPQRQQQFSPPPGPPPGAPQQQYYPPPPQNYPPPGHPPPQHQQSFPPPPQQSQPPTPQQQQQPQHSVQQTAFDPSRAGPPSQPQQVASGGGASTVTDTLGSFNGGSYRIDHRDCNTLLTLMLAHGCPVTAKPGAMVAMTPTVTLKGSVKFSLKKMLAGGEMAQSTYTGPGELLLAPAALGDIVPIRLDGQQTWSVGKDAFLCCTQGVVKDYKSQGLGKAMFSGEGLFVYKISGQGVLFVTSLGAIIQKNMTQGEQFIVDNDHLVAWNCKYTIERVASGGIISSMSAAEGLVCRFTGPGTVFIQTRNPTAFGAWIASHVPPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6T3</accession>
    <name>A0A2T7A6T3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1039085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6T3"/>
    <dbReference type="STRING" id="42251.A0A2T7A6T3"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="650" mass="74781" checksum="657788B644BDB04E" modified="2018-07-18" version="1">MATIQTKPRSGQPLDPPHYTELINRYLDSGHSIYITTENFTVARGQMLANTSRAIVSLMRVPFSPYFDTKFILKWFRTAGFAQAPVEQAEVEAGSLHHAAEAFRRNNNFSRAPRVYAIRANENYIAQECIPGRGFRDGYPEWWPKERLIRFVRQVAVARLALLSQVENQLGVPRHSPDGRRVGPFCSNVWWEGSQHRFWNEINRGPFPNRHEQILASLRRDLLITRWRRDRHDILPDHYHFHRWEDAISYLETTIRNIDQVPRPTNQELFSLNHGDLRDGFNVMMRGSKLVGIIDWEAAAYDHLSLCIMDLSDPTDYNPREWRAHAGPNGENFHVLPYRLETENMEGRMEHLTTVGAERKPFPDWELIENNGGPLGEEDFYGDDYPEDISSADDESIIDAAEMHCDSDAEAEESCVLPEDPGNRHPGENQRRGLAPYELLEDWYYEPVYALMREFIHRQRGAGLGPNGEWGRLPEAYSRPLAEWEDTLYYRVTQRFFDGYHRQLIDEDRVDAEPRLAKGPRAKKSKKQPRQRRVPTLMDGWRDAAAAGTEIPPESPESSGDSWAKDRVPRRIRPSPPPKPRRVGPNPDPIPVSTLQKEQALKRAKQRGKADPPPVKLPPAGARVRGVRDRIAAKVMEKLRDRLGRGADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6V6</accession>
    <name>A0A2T7A6V6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1189585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6V6"/>
    <dbReference type="OrthoDB" id="10469145at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="27754" checksum="304131EA2292E965" modified="2018-07-18" version="1">MGGRHSHTRGPPGIRVALLSHPTNPACMPDTEKLRTIRLITAPTAEITPANAVAPEFVEVTEGNFGFSDAPGSISSSLRAHTSSDSDSDTSEHQRSVLREAYDDIKTAVKNCAADNTSAAPVDIVGDSGDIDPCAIPIPSRPSGRYRCRQSSSLLGATPPRSARAERIRDDLALLATALGNLILEVYHAWCDNGIMGLIKTWAILMRAWAINATYLRTVRLLKPVVVRNDEVVNFAKTLDTDSFKSSKNALPSFVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7E1</accession>
    <name>A0A2T7A7E1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_779773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7E1"/>
    <dbReference type="STRING" id="42251.A0A2T7A7E1"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015414815" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="32309" checksum="39DA008C6EF139AC" modified="2018-07-18" version="1">MIPVILFLTSFATAALAAPKIIWDGRLKMDFPATDLDNSTTSPYNAEYVLGAGQKWSEQLVFPTMSVTGPSLFDLVFKDCRKPVEVTINNKSIFAPGGNAQKGFRRSELLPSINNGTDATVQGTTTLHLSVREDVHRSLNYSHEYQIAFIETNDFSSHVWTLKTGTPFGSSEVPAKDAKTLRLTSSTADGKAEEVLFSVPFDSGCWHNFAVQTNWVDSTISAWYSSGYGFMSEVVETRANNATGKGQAHIGILKLPTPPATDPSHEGYQPSGINEGLIYGGIFVEDSSQNGVSLTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7L8</accession>
    <name>A0A2T7A7L8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1060809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7L8"/>
    <dbReference type="OrthoDB" id="5354748at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="413" mass="45437" checksum="3C2AE249BBD71CE5" modified="2018-07-18" version="1">MSSLQDTIQSLESLLGQQLNTYEGYKARLATVDATDFAVAKDKLSAALSQVLGLLEYLKVADDRLLAAGAQETHIEPEFENQAASVHDRFHEAEGASSLGLDHINRLATEIAEFQTMGLARLREQINAGKDRLDSLSNQTNEKLDYLERQISEIQNRIQATNNATRDVQAQKESTQSTLNNKRNEVNNKERQRDEAYAESRRAKERRNNARVAGAGLGVLSLFAGPLAPVVFAATAGSLIYADNQDDVARARQNEANLLRQECQTLEILIGGQNDRLTAHNHDLQRFQNERAQAEQEKEALAREQAAQQTEKQILASLEARVADLGSHVPSLNGKTAALSSEISKIRTHTMNCTVMISEARIKAGYLEYADSRKEILGTVKTMVSGFTIGDGVVERIGTAIKELESRSLAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Q6</accession>
    <name>A0A2T7A7Q6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1172664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Q6"/>
    <dbReference type="STRING" id="42251.A0A2T7A7Q6"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="969" mass="108672" checksum="DA1E421AA3361B4A" modified="2018-07-18" version="1">MAPSEIDFYKVLGVTRYATEDDIKKAFRKAAKDTHPDKNPGDPLAKEKFQDIQTAHDTLKDNLERAKYDEDNPYHGYPEGTFPQPNKKSGTAKRYTTAAQQQPQSQWTASSSSTFSTRGFAHQSGTRPSAYKTTYGGGPPEGSSYRKSRSGYDHNGAYRSAAGHDDGYGYYDRYRPDSPRDYDRSSSSRTGPRQSTATPNSSAKTASSSSPRARPNSTPNPPQTDPAAPTPDYDLLAYIRERQAREAAAEADQKKQREEEEASRARRAEMEEYARKAEKLKKEEERQNKERERAKAEKEARRAEEEAEARLRRQWNETNGHHSRNGYSQADPPFANPFPYAEEDLEKKVDEELRAAKTKSAASTTSKQRSKRSPTKPRPQRSHESDANGYADGWSKPGDNSDNSGGFAYPFPKGEDGGEPFMEKILRKERERVAKERQQETSAGQWENPPRENGSRSHTRTKSDPRPPGRQGSFTQPEAARSSPPSPCAEPENQSPRIASPTPRRTDSQFRSVPYVTPDLTTDHTNFSRSSFQYDSAPDGPARKDSYHTPEAATMPMGQESPFSKDPDFRFFDNKPQIDPFNYTTTEELFPPKQSFARPQSQPVYPTQPQHAPVPRQTPQPHTQQQHQARQQPDNPPFKETLWDNLINTTKAFDFRHEVPTAALRSPKKKMSGSSISKGKGKGRETTLTPDPINLPTHNFTSAKYEQCPIDTTDPIKPEPMENSKSQTNHQTTVEDDVDAMDTAPDTGVPSPTVGVGPKLPRLSIGRPGNSGPASPRSPLPGQLGGLDNLGKFMSVPPFKHASAGLENFDDIKSNLPLPSQVSIQPRQGPTPTLKGRLPKVPKPDIRDLYEPQTPAEEPFAVPLPPKIPKTPRTVTLESYNKLFYGIEPYIKKWNEYEGKYNDLHTRLSSSGLHHVITLDGNTITNYIARVREKDTILEDSYRQAREKHMQALEGWVNYRKAILELRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7W9</accession>
    <name>A0A2T7A7W9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_754088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7W9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="10298" checksum="5135FDD48756F6E0" modified="2018-07-18" version="1">MWFNIFIYLSLLKGLLVFQKPCFPFLLLALIFPFTLSIGFPGTLTITLFNCSGLMASCFPTFLTHPQYIRFLERYTGREIRHYQYCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A858</accession>
    <name>A0A2T7A858_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A858"/>
    <dbReference type="OrthoDB" id="10403671at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="16406" checksum="E3456E38F37AC400" modified="2018-07-18" version="1">MNPPTNPFTTLLSPLTKATSTSPYTPLVSTGDIITMSIIGIFPHGVQGAYSPTNISTSTSTAAEVNLYIPNNSLYSTGLMLSQDGRRYVNANGDKVLSVGGEVEVKVLLIRKGGEVGVFHVVCGAVSTAGGRAGTLKREVRMEMGGDGDWELGMVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8N9</accession>
    <name>A0A2T7A8N9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8N9"/>
    <dbReference type="OrthoDB" id="5414234at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="343" mass="36259" checksum="1CC6752FE0F86CAB" modified="2018-07-18" version="1">MSRSKRSKKAANRKKHRAKGNSEKVLVASESEADTASDAGGPVTDNAGEPANRAVDGAADLELGVSSSLDESAVSSDCGPNSCKLKADTAVNNEARNAGDITKRAVDDDVDLMPGVSSSLNESAVSSDCGSDSCKLKTDTTVNHGARYAGGDFQRMLGSFSACFKLGAAFSRGFYDGVNEADALRNRADEGGHADSNQSSGKMGFKDKAGDRHNKKGVGRKRIRPNAALTEEEEAFITGSDLPIYLIPAMQEVIESRKNYKFLRKQGGSGKARILFEENLARHGLVHAPNGVDSRLFPKRDASSKDVPSERSDLANPDDSAQASLQEGLSTSPEVKEGISGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8V3</accession>
    <name>A0A2T7A8V3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_893793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8V3"/>
    <dbReference type="STRING" id="42251.A0A2T7A8V3"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF8">
        <property type="entry name" value="OCA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11587" checksum="D5F8692904B2907E" modified="2018-07-18" version="1" fragment="single">AAKFMSREYKSLIAKGGTSLLTAPDQDGNTPLHRAVIAGHRAMLEALVKKFAAQGYGIQDNEINKKNRGGNTPLHLAVQFDHPHIVKFLIENGADPTIENNAQVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A969</accession>
    <name>A0A2T7A969_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1098253</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A969"/>
    <dbReference type="STRING" id="42251.A0A2T7A969"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU84281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="99" mass="11060" checksum="520FB854D8609BA5" modified="2018-07-18" version="1">MLFFSFFKTLVDHEVTIELKNDLSIRGTLKSVDQFLNIKLDDIMVLEEAKYPHLAAVRNVFIRGSVVRYVHLPAGAVDTALLEDATRREASNAAAAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9T0</accession>
    <name>A0A2T6Z9T0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1012170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000672">
        <property type="protein sequence ID" value="PUU72196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9T0"/>
    <dbReference type="OrthoDB" id="10400158at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="8284" checksum="E44BF835DA1E6EA7" modified="2018-07-18" version="1" fragment="single">FSYHFIHFFTSNSLQMSLFTILLEGALLSHNPRVRKSAFKSFHYFLIQPQDSLPNTSSLRRYTGGEKIFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAC7</accession>
    <name>A0A2T6ZAC7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ETC complex I subunit conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1137571</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000533">
        <property type="protein sequence ID" value="PUU72451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAC7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAC7"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="415" mass="46259" checksum="124C50B6B8A05F5B" modified="2018-07-18" version="1">MSFEFPNATDPEPIRRSLDASCPSKAAEYLSLTGRDRDDEADTGWDLNSYGELHCERYSVSIAYTVQTGLRTEKQGIARMNEQIISMGAQQLVPLVLVSWATRRKVIFDTFLLYASPRASPTPSKRSKTAPNSSEPPDDGNLSEAETSLITEWFSHIPRKLFPKDPCLSIAQLPSPQLPKMFPSLRLFAQVGTQRLAPFSTTGITGILTHPNPRPALIAVYNHTLSLLSRLPQHSVYRQSTENLTKQRLAIVESVKPEGWTEYQAALKSERETSGIQGARDTEFELKVVGKQFLAMVNAVTTDSPVIQAFLDKEVGRWGLTPPVDTSDAYDHDADVLAEQEGPSSEVPLLPEEPPLYAEQVTELEEKIGAGLIEEVLEQGWNELNLVKEMEKAKVWEPLEVQPEEGQWVGFERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB83</accession>
    <name>A0A2T6ZB83_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1069567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000479">
        <property type="protein sequence ID" value="PUU72706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB83"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB83"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="294"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="613"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="779" mass="83714" checksum="94FA75FC018832DC" modified="2018-07-18" version="1">MASVPPQTRPLQFGAHHQQYVPNGSVPGMPPQPVQLPPQKVIEKAGVRILCIADVRGNLRSLNELAKKANADHILHTGDFGFYDDSSLERIADKLDFNPNTETLRHVAQYSPLLEEGLKKRIQNPGPSSHSIKQLFGQVEHPLSELPLFLNKKYTLDVPVYTVWGACEDVRVLEKFRSGEYKINNLHIIDEANSRLLDVGGVKLRLLGLGGAVVMHKLFDNGEGRTTIPGGQGTMWTTLLQMGELVDTANRVYDPTETRIFVTHASPAREGLLNQLSVTLKADFSISAGLHFRYGSSYNEFSVNPTLDHYRGKLASSKASFNDVWETVKGEVLPAVQQNEAQQALLNNALDIVEKMPTSANGGNPFGGPASNTAPGAGQVDESAFKNMWNFNLADAAFGWLVLEVEGGRIGTEMRAQGFNFAHRGGKGAPATQQQQQQQQQQQQQQQQSSVAPATSTATSAPTSNAGPVNVNVPSGPSGASNTTPQNGPAVPFTPSGPRNQQQPMPAPPQPKPVTTPTGPKQPTPPPAQAEPPVAPKPATPRPVPSGPANRTATPVATPLPIAAAEKPSTSNGTRTESPAPPAMPKIDTPATALVAAPTGPQHQEASSPQDRQKQFGLYVTGVNTPEEVHALFSSEIRSKIQRIETKHPRSRPENTYFFAYFESIEVARETLEQLPEDLKVKRSPGEPWVKLMDDFAPFSNSRPGMSDSKWGRGTGTGGGNTSESDNNTGGGYRRGYHRGRGRGAYGSDRGGGQRGRGGPKRGRGFDGGDGGSQHQPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBK3</accession>
    <name>A0A2T6ZBK3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1197299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000450">
        <property type="protein sequence ID" value="PUU72877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBK3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="18182" checksum="4BD725F62150FA04" modified="2018-07-18" version="1">MDLQEEDGQITEGHSIRNLRRDSRQTFIDGTSFTAKDVLETPEILDLVLQNATPEGALDYSSLLRAPLKFSTGCQKLRDIAIMVRDYVIRYAREHPYLLALNIGLMVAGFAVPLLLGDWGLRVPELLLGVRRRHGNLVWELSREAACLPFVRVLGQRGLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCJ2</accession>
    <name>A0A2T6ZCJ2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1095743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCJ2"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015450560" description="Integral membrane protein, Mpv17/PMP22 family" evidence="7">
        <location>
            <begin position="28"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20452" checksum="1D6A37DB3E539300" modified="2018-07-18" version="1">MSAIINASIQAALLSAFSNLLAQSLQAYKLNTSLSFDFTPAYQFALYALLSTPPNFIWQEWLEAAFPANVSAPVDGKVTGRENGNTVRPTRVSKSNTLKKFLLDQLLGGPVNNALFLAAMAGFRGLPMEGVVQYVRAEFIPLSLASYKLWPFVSIIAFVFLPVERRLLFGGLVALGWNIYLSLLMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCT6</accession>
    <name>A0A2T6ZCT6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7932 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1197005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000389">
        <property type="protein sequence ID" value="PUU73311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCT6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCT6"/>
    <dbReference type="OrthoDB" id="5319158at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057692">
        <property type="entry name" value="DUF7932"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25560">
        <property type="entry name" value="DUF7932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7932" evidence="2">
        <location>
            <begin position="283"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1059" mass="114038" checksum="D9FA771AB7343E89" modified="2018-07-18" version="1">MLYGEKILVSVDGQAGEPGYQTYGHRNRIAPPGHVGQNGRSSCSATPGTNAGSVALELTPSPSEPHGVHAEGVGAWAGTRWEISTDKTLYLSAKGGDGGDGGQGEDGQDGGKGARGQDATKHRDATNGGPGQKGGDGGYGTDGADGGNGGSVFVRVNEQDTNLLLALDWDISGGKGGNSGVHGNPGDGGEGGDGGVGCTWEEFEGYYYACCGGSYCTCGRHNRQSRYTRHTRPPGNKGNQGPPGSRPHSYLRGGAGGVRGAAHIHISNLDGTEAIYPSRYNIVVVGFEVVDENGDGINEPGEHILVRNIYVQNTGGMHTPTHSKIPVLIHGSMWLDPIPEPVYLPVGIQPGETVEVPGVLRAFIQQERSARQMGVKFSATDEMKLIGVMPGIDRVLPDFCGSTTINISYPLELEAPRFLNSVERGSNVTFSWMLKNVSTKSYGIRGSLGRSAGTCLSENGGARVFTFVDESNMGDARGLDLLDTLDPGTAVTIRQTFKVSDQAEPYSTGSMTLELVLSEPGNNEGRYSPLESAHFPMRSVMHYPLDMQISAKYTYNPAADYLLVVNADTKREVIHQICGLVADLGLQLDIWNMSVYGNFRDPNCTIPANADHVFYNYMGKSIVVLANPFEYFQRGMRTAFDLLDPQVVSYLATGGTQFLFPEAAASNPTWTNSVLFPTRPFDGTPDQRPGETTKKGVVAKVKGEGPENMWIPSKGKLFKKPQSALNSDAKGVVQLLNKNLPMRRFAVSPSLEGSTKNVAGKIFIRHGLSLSTRIVTAFGRWGIEDARPSELNSYLLIAALPFRKRARLFWNYVGGTLAAEVEPQGVEKTPVVNVAGGMSSNARIYKAICLSIMYELELEISQFSASAPWPDVIPTTDILKQLEKVDYFFSLIPNPSKIEGTAASDLDFLVETLGVLVAGIVPIGVSQWMGQKVIRLGNRRTHLRTQVLARLETGLRAIFDDVEAKKLKGRIMKECATTKKALKPAGGTILKVVLSKIAAYSEEDFSTLPFYDSSLVSTKSEVWTEADVDGRINAHGQVVGKIADDERYSEAMLKDMVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCU7</accession>
    <name>A0A2T6ZCU7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_550717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000388">
        <property type="protein sequence ID" value="PUU73312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCU7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCU7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="283" mass="31277" checksum="2C35247ECCC85362" modified="2018-07-18" version="1">MIEYLVRNEIFTIVDKNALLHHAAETQSPDVIETLLDTCDLDVESKNYKGRSVLSVAASIGAVDIVKLLLYCCKNINLNSQDLTQSTPLHLASSTNHSSAPALLLLLLHDPRTDPTLTNQFGQTPLHIAISRGCETLVPILLQHPGVNPNQPDGNGHTPLLIVCEKGYNEIVKVLLEHPRIEVNATNGQGWTPLNVAILRGKVDVVRRLLADERVDCRARAPRFCWTGLHLAVARGRREVVEVLLADCRVRKDLTAVDEDMNTSMQLAVKWGIEDAVEVLRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD06</accession>
    <name>A0A2T6ZD06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1034932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000382">
        <property type="protein sequence ID" value="PUU73372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD06"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD06"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="197" mass="21277" checksum="9308049E51E787F7" modified="2018-07-18" version="1">MASNRTSKPSPLGYGLSPNTSPFGTPRSTGNMKRTSSGAFTQLSSTQIQELKESFQMLDKDGDGIIGKEDLGAMLGSLGQDPTPTMINTHLSSVPTPFNLASYLTHLSQHLSLLTPGPDLLSAFAAFDDNDDGTIDVAELTEALTSMGERMSETDIERALKGFTKRRALGRGQTHGGDVFRYRDFVDVLSGKEEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD68</accession>
    <name>A0A2T6ZD68_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1034869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000377">
        <property type="protein sequence ID" value="PUU73419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD68"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="8676" checksum="655536A0FF8E4F2E" modified="2018-07-18" version="1" fragment="single">MERPNIPSALRTAMVALRASDSKKVYVHKALLNSKVMATGGCTWSCFPSTTVTSFIEYLYQGDYTSSAVITSSGASESACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDL6</accession>
    <name>A0A2T6ZDL6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1103863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000364">
        <property type="protein sequence ID" value="PUU73591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDL6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDL6"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="333"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="465" mass="49534" checksum="CB0465FC7971F18E" modified="2018-07-18" version="1">MNRQGPGPQMRLGGFSQASSASASRPVGGMPNGKLGGSGWQGGPPGVPNPPGSRPGSGLTFSQSVLSSQPGTPLDMNDFPALGGQPQNPNVQPWNRLNTQSPSAQNRPPQPEDIFANMDGYRMSGVGGVGGVGTQAQARQAMQPNSLDDFPALPRTQGNGDGIEDRGFMSLAGLGGTAQFGVRQGSLSAGRSGLVMGGGSQSSRLLDTVIQQTGNVQISDLEKKNLMKTNLSSMAQHSSPAPGMQNPVGHSLGAQQQQVQQSKLSSGLSGVDFGGNQPNSMQTSGMGETDRFGLGGLLSLIRGESGDYSMLALGQDLTQLGLDLNQPEAPLYPSFASPWADVDSKPVEPEYQLPPCYTVQNVQSLGTKVSSFSDETLFYIFYTMPRDIMQEVVAAELSSRNWRYHTALKLWLTKDNASDIRQISENAEKGIYVFFDPNAWERVRKEYVLDYTFLDHRAAPGIMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDT8</accession>
    <name>A0A2T6ZDT8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1094655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000357">
        <property type="protein sequence ID" value="PUU73655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDT8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDT8"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002157">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000104">
        <property type="entry name" value="Transcriptional repressor protein YY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU73655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="415" mass="45726" checksum="9E45E2513A30A378" modified="2018-07-18" version="1">MSYQYPHSSPPRGSPGSTKVSNPNHDVDFQTDVDTLMKAIQARQPVVIKAESNSPSPGYPQPRQPLKNTPVTPIHPVGFQNRSPYTSNPYSQNGYPPQLSSNLQVQASGSGLGVPKLLAEDEDSPARGGKEEKKSGSQKAKKRYECDVPGCNKSFFQKTHLDIHSRAHTGDKPFPCSEPGCGQRFSQLGNLKTHERRHTGEKPYSCDFCGKRFAQRGNVRAHKIVHDGSKPFTCRLDNCEKQFTQLGNLKSHQNKFHAVTLRQLTEKFAQVRDGDDISVADRELFEYFAELYKNSNRGIKGRGKDRKITGTKKPRLVDGEMGSDAGRHAGGDMHSITSPNGSCGSNSNPDAAFDFSGGHMDEEDESSVDSPYEQQQLPPMRPGAGPVAMVPMGAYPDDTMALHTDMAKYSLDRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDX2</accession>
    <name>A0A2T6ZDX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1003606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000357">
        <property type="protein sequence ID" value="PUU73646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDX2"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="127"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="418" mass="46582" checksum="5F75DD402181D535" modified="2018-07-18" version="1">MPFWPAYPTPHHSNTPIILETKVKPLPFPDFAASLLTPFRANPLLFNGHLQTFWTAVKWNDPHTIYYARQRLQSPADGGHFAVDFVVLEPFPSAPASTEAMGGELPPRTRDMMEEEVVKLGSDDDTPMVIALHGLSGGSHELYLRSVLAPLTRKVEEGGSGFAACVVNARGCALSTVTTGQLFNARFTADLRQTVRYLQEVYPRRPLYALGFSFGANILTNYIGEEGDKCVFKAVALCSSPWNLEVASKALHRTYLGSEVYSKVMGGNLRNLFEIHIDNFSGDPRIDVDLVRRGKYLYEFDRDFTAPIFGYATVGAYYRDASSVDNLLKAHVPTFILHAKDDPVAVDEAVPYDEVKANPYCFMATTPTGGHLSWFEYGGGRWFARTVRSITPITTEYNIDIIPGRRFLHSIRNRGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE06</accession>
    <name>A0A2T6ZE06_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_511477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000349">
        <property type="protein sequence ID" value="PUU73728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE06"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE06"/>
    <dbReference type="OrthoDB" id="5430360at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="403" mass="43857" checksum="EC8462FB9EA2AD9D" modified="2018-07-18" version="1">MKYSSSLIAAVAACSYFANARPTEILEGPEKGIKGIGFEEIQVHPYSTFKYGGNYGEGYGGKFVGKDDGGVGFGGEGFDCGCIGEGIGEKGFDCGCVGEGIGLKGIGGEGYGLKGIGGEGVGLKGIGEKGLDCGCVGEGIGLKGIGGEGIGLKGIGEKGLGGGFEKGTGYGLGEKGLEGGFGKGTGYGLGEKGLEGGFGKGTGYGFDYGGIEKPGEVFGGYGLGRGRGFRGRGEKDDGGYGFKTVEHRPEEREKVFVEKKDFKKEDKHRENREEERAAENRIFEECEECDRKEFDRYKDINSCHRDHELEKAKHAFEMGYGYDKGCKYDKGYGYARSYDTEYERCDDDAEYERREKEWADREEKEASEFYENPRIFEEAEECKEKKDLTKCDTEKEKLECDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE23</accession>
    <name>A0A2T6ZE23_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000348">
        <property type="protein sequence ID" value="PUU73751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE23"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE23"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9983" checksum="B95F6B7018413857" modified="2018-07-18" version="1">MLLSADVHTLFDAFKVSINPDDNYKVVCFAPDALNLYYNIAGRHLDQTFLDKGNRPVDEVLRWHYRQAVLVNIRGPGSLLPSPITWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE48</accession>
    <name>A0A2T6ZE48_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1161749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE48"/>
    <dbReference type="OrthoDB" id="10675560at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="483" mass="50104" checksum="99F00CD5256255B9" modified="2018-07-18" version="1">MPPVCRPPKSATIAVEITAEPENFKARPAPRKAPMSSIPKKPTKGGGKAKRAPKKKRGGRKKKEKAEEVESSGESVIESDIKDVAVVVGRNEIKADFVLLLAEYSDNDSADDADDGGSSAGGESDFSEYEDKSYVIVRRPTPKRATDKGVSSKTSSGKNATTVSGGSARKASAGKGSAGKGSAGTGSTGKGSTGKGSTGKGSTGKGSTGKGSTRKGSTGKGSPRKGSARKSAVDESPKKREGKSTSGKKGRATVRNTAGENSNLLDDTEDGYYPDDENDENDKNYLETSKTPAKRAAEKATGGSVGKGTTSKTTSKTSAGRKTPTKATVGVTTRSSLRRALMAPEGEELPMTTAKKRKAPSQEDSRLKKVPKTGTAKNVGVVRVGLESLSLGGADDDDVGEVDGSMHISFGKPNTGYIIKGGTYPNSENTAEQRAAVIATNSQSHYVLQSEPVIGKKSMRYGGKSVAGLKALWEVGPPKYDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEJ5</accession>
    <name>A0A2T6ZEJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1068600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000333">
        <property type="protein sequence ID" value="PUU73928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEJ5"/>
    <dbReference type="OrthoDB" id="5417219at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="264" mass="28931" checksum="4FC0E710F08607B0" modified="2018-07-18" version="1">MTGGMSEEWPSKVYEKQLSNGCFANAVTPGAKASQETRGAPALPQPSSPTTLPQPSLPTALLQLSLLTAPPEPTLPTTPQHSLNSVHPPNYSTSTIRIQPASRLCQQRTPYFSTSVLKGNMAEMKFSTSAGPNLQAEPIVNKLDGPDSIAGRIYQLQTEIKIANMKGNAFTSHSNRFHDRTESRFEWLMAFGIGTVLLGVGGAIIQVYNYDLAQETQMRAYVQDNVGHIERAMMTYISNYEKVTGTKIAHLEDKVEMCLERGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZET9</accession>
    <name>A0A2T6ZET9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1001968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000328">
        <property type="protein sequence ID" value="PUU74005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZET9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZET9"/>
    <dbReference type="OrthoDB" id="5405293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="19553" checksum="77BAEB15837F335A" modified="2018-07-18" version="1">MGDRNLVDSNPLSPNVAAHQGEKATLKEEQVTFQHKYGALEQRHAALQREHATLRGEHVALQQGQLALKQQLVALEQRMDTLQKAVPVLRDEISRQERHSIARVVNSTATRHPITLDPFYGVDGELAPGFPVTLGDARRLNGKILNPLLLSLGFPVSGSVAVRKTCFFKYVGLVYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF32</accession>
    <name>A0A2T6ZF32_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1033761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000323">
        <property type="protein sequence ID" value="PUU74100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF32"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF32"/>
    <dbReference type="OrthoDB" id="5426403at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112798" checksum="03F28F40F8EE249A" modified="2018-07-18" version="1">MRLQVHVVPAGSPATAPAACSFLEIASPTLTLEALCISISNRFERLYPHRPPLKIDKIQDSNGNDLDLGYLVSDVFSDKLEDNLNSIVRVLQKSTLRESSIPPESSLRPQFARKRRRLGTVIEVNSNTSQEPAPSPHSSERGRIRERFPKRPRINDYVVQDSMDDREEGEQRWGKGTIHNNRFGAGHDGSEMVEVAATQQSGQLSPSLGKRTPSPEIAITGMVEHPGQLPFMEVKVEDKEQAGEIQEIHYSSPYLPREPGSAELDHHSSPTLPPNPTQNIDTVANGIRRSIYDIPTSSSSEDEPSLPVSSRSGGRQRNGNPSQSPMLRKRRAEEARLAAEKTERERAKEQAAAREKAAKAAEARKKAEEAEKERLAKEKAEAERREKERKEAELQEQKRIAAEELEKQHKEEERKRREKTEHEARIAAEKAEKAEKEKLERERLENENLAKEKAEQQRLVEEKRERQRIVKEKAEQEKAEQERLEKERIQREKEEALNEKKEKARKQKLARAAEKRAQAAIERAEKLEREKAEKLEREKAEKAEKAERVAREKAEKTERLEREKAEKLEREKAEKARKQAEYEENNRLAKEAKKQAKERAKGLALNSGKEAPSSQSLPQSSQALMADSESPVPTPNSTLKRSNLKTKIPEGSKKRSSVSFAEDLTEISSPTPTGKKDTPVPVLGSKVTPILPPGYGANKLIAEAVVMKAPAKPAAEARPPTKKTKLAVLPPKPTSAKKTSPQPSLVPVQASLRRQKEREPALKSKPTLESGSESEGSTDSGPGESGSGESEEEEEEEEEAKPSSKSSVFKKSTARVKSAKNASLLMTPKPPSSSSAAANSLRTPPTTHQSTQHSSRPSPRLARKTPILAPPTPAMETDSETGSEEGIDSASDSDFGPAPRTTPTAASAKTSKPKATIATKPSPLQPYKSLTDLEKMPVPDVHDIHSSQAPQNPSTLPPPSGTIRKKYEEDDDSSEESSESGESSDDEGEVAGKQVINSAKKAAAAPAKKGGFLSNFWGRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFH2</accession>
    <name>A0A2T6ZFH2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1001314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFH2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFH2"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="9">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="200" mass="22566" checksum="E7AB3FAE5DB78F84" modified="2018-07-18" version="1">MNNNNHSANGPLTPAEVAFLCEAQSITIIPRQRLDGLDLIGGYIPPFHPPQRTAIPLWLALLLKRQRRCNIVPPPWLSAPNIERILKIETENQNFFCPDLPYRWLETAELLLEACPDDLGGDDGELRVLLRGLREVRQGKVREGLGKLEATYLQMNNLGLLEITEVRGFAKGVVDGLRKIGASIEVELVLGWMMMMMIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFI5</accession>
    <name>A0A2T6ZFI5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1033626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000319">
        <property type="protein sequence ID" value="PUU74174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFI5"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="400" mass="45602" checksum="18E150F92FABAF74" modified="2018-07-18" version="1">MGVTGAGKSYFIREVTGNPEVKVSRGLYSYTSKVQSYSFEYEGAKITLVDTPGFNDTEKSDTEILQEITAWTTTTYRQGQLLSGIIYLHPITHTRMEGSAMGNLRMFRSLCGQEALSNVFLTTTQWSRVDRTEGEFREDNLREDGLWGGLIGKGATLQRFHGTRESGLELIRKLMLNRPERLDIQDQIVEKRMTLFETGAGQCISEELVKLVEKYEGELESLRKRYQEAMEAKDREMGEALATEREETRRKLASAEDEKAKLAKLYEMEVERRDEEDRKSLKGIRKLKKSGSSREVIAIATRDIAGTAHFTETFTSYTTRGRFVYDINNEEEFESITFELAISYDLNSSNFPVDTRTIREMLFTGTGNTNYISLDGICYRCRSGAPITRGGQAFLIFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFL5</accession>
    <name>A0A2T6ZFL5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFL5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015520353" description="HMA domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15198" checksum="A58B30926373C403" modified="2018-07-18" version="1">MARARLSGVLFISLPSFVLSLEYSTSILSFLTPPQYQINTSQKNRSKTAPVNAFGPASCSIFDEIAGRGAISQCKRLLSKPVSVQAPKELELNMNVTYGEQQTIRRAIADYGFHKIEMKLPQRECNDSCKTAPVVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG61</accession>
    <name>A0A2T6ZG61_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1092772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG61"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="18299" checksum="0D71A7686A361730" modified="2018-07-18" version="1" fragment="single">MSAQYDQRLQTYSQNSIRPTPLTRSQPCRHPFFILSTPDHHPPCTIHHIFPPLRQQTHTHLFLLPHPKSAMLSVPSLAFSTCAPIPAGTLSLILLCLSFSPLLTTFSNSNLQSATAFSSSSYFFYPPAPLFTHIQKHTSHPSKVSIIDTVRCCIVVCLPVSYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGI5</accession>
    <name>A0A2T6ZGI5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1092474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000291">
        <property type="protein sequence ID" value="PUU74566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGI5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="10189" checksum="98522D55F01CF644" modified="2018-07-18" version="1">MEVLVFLQISVPVYVFHPLTHSPTHYRNTTSIHPSIHKNPLLLQNPSCSATYLPKHHPSPNHDRAHKIRFIHLHTTRRSSKLQCAPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHV9</accession>
    <name>A0A2T6ZHV9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000251">
        <property type="protein sequence ID" value="PUU75087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZHV9"/>
    <dbReference type="OrthoDB" id="5390479at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1339" mass="155022" checksum="182AFFD870C59E21" modified="2018-07-18" version="1">MDEARFYIDLAAKVYRNRAFNMDTLKSIALSDFGGSLGRYTWIVIKPVATHLLLNEVFSHCITPFVLLCWDIWANDAQYPLRTLHWLNLWVPITINKIVLYPSVSIAVVPLLMAAFTLSYLRVIQGNGVHPLELWFWQTCGDEFDWRLQYRLAQVLEERQIRRREETYRDILETPLLTDDEFIDVITVVDGIRTRKETAHQAQLDSYREYSQENNTFPTIPVLDRYYRAGWGTSIYMLREFDSNHRFCRPVRWHTDIRTGVIDCFNGYKTRHSGDLMANHEDLVVGSISVMRPADIRPALKLIKGVFNHLKFFSTTYMRSGLHAQRQKWCEGIAVHVEYLHFPPEFERGTVRKLDVDVVERDERETQSTGDGKESVYVQKDRELINILTITVDKYCVATFYVAHMLRTPNSESLEELRRLFRFLMSPLRTKIWLDLPRGIAALDATMEHCYRGRRAPDEPYPKRRPFREFPGSLMRYPSFKDVGPADHFYVDRPVELNFPRGSRDCPLGLHANIVDYANRSCPCFSGNFDFRDLLDTILRSYSFIPYSEHMGAGRDEEGQPTGFTIPDCWAEQRVSFDYEEFISWMLAGDRYLPLLYHLRTGGVRKPIMPVLRNLSEGDANRAREAYEVQLEVYQNDQRNFARALRNPVGFEQDDRTLGYVIGTGVGIALAFRLLLTCEIPRVTAERLSHYGYMENIEVHPWATETALFRPLPEIGVLSSEGNALGTYQLELAFDRAFNRRDPEPASTVVDGLIVDSERYKFFQTHELLPATLEREIRRSFAEMGMEYPGWVRPPPSAGENEQSEIEDLRESLGPRIIRNRLRSNGNFRQEISVTNYAVSSLIKHSFNQSDDLGLADEAVENPRQNLLVYARFLLLIQAHFGGTDMMLGQGIDGLVAGILGGSWYRSLPPEEQERMQNLRNWYTADREAARNATRRLREDVCTETLIVMLMHEISKFEGLDGRRRTALNLEVMRENYAAYTNESIYQTHEARSVMDRLQLGGVFQYEEPFWYKRLQVRIGPLLAEGEILAALGVEWQCGFRDMDEILYHLVGEVEKFTKLNELQIELSRLLVNVCVDAGIPIDYTGPRRNIAKHIIPDTLNAILRSVHTASEVISRGISRAILFVGNFIRHPPGWTPSPFPPARPDRIVDDFPDVVEPPPATTWQLPIWCTYLLNDLTLYDQTHQTPPPSNPRRVDELNALISLLILDPPITPNDQIQYTKWWSRRVRFQAVRIADEHIELFRLPDLDLINPTLEGTYYYPGDEFGMDLDALDLIRRENVRARGVALQRALDEENADDGGSDSEMERRRRASDLAWRGWSLDVRDYFRFAPARRWRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIB6</accession>
    <name>A0A2T6ZIB6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1154483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000241">
        <property type="protein sequence ID" value="PUU75240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIB6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIB6"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="415" mass="46740" checksum="CD48651E792CAB54" modified="2018-07-18" version="1">MTISLVLERPSLTSWLRGVPPHDRRVVQFRGIKFGEFTERYAKFTLVESYPVETDSTSHGHASFCLFSRIPENERKRAAAGLTQNELECLSPVIPAPNSTLNPPDSEEVLPMISGGVPLLDIANFVKKSMDIGTPIPLEQRWVQKHIHGFRSDPKMVTIGGNSAGSFSTEAHLNVVPESDTKGLFNRAIMQSRTMLSRRLRRMGFFTRGWGEVGAGAPEWCDALLIGDAEFNIPRRNRRSPLSAYQIQTGTPPSPVPAVTKHDSTLQFLLDLLVSFPNHRIPTTWRRKNKQVYEYIRPAQPMGPQNWRAHHAAEMLSLLGIYTFSEETHEAMRKAAMQEHFISFIRGDVLFEAAEGEAMKYRPVGKVAVGWNKDSRNVSAWKVTEGLGRDVLVKTFDIVGGCIEHYYFSHDQPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIE0</accession>
    <name>A0A2T6ZIE0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1131568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIE0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIE0"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="75"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="635"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="858"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="892"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="928"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133797" checksum="D7C7674E04DFF787" modified="2018-07-18" version="1">MEPGNSQTPLKLLSNGFDPSRNRLQHEFSSPGETKKSFSPVVSSPRSDYPENLQDFIRLMKSANVEGPHFQRQVHLSCKSLGSGAQFDVFGHQHFVHETFPPFDLPYVAKIQGSGKARVVVAVKRARFMHSYVGASASTSQQFGFGTPEQLRALTLEVRTLSNPAIHTHRNIVKLLGWGFDFGDAGTRVEPLSLLLILEHGNCSLRYFLSNHKRNIPNPTEQVLQKLGLDVAQGLSALHDAGIIYGDIKTDNVLVFPAEAPSFCIAKLSDFGFSVLDMEKNRKIYNIGTPGWQAPELGDIGVSADMLTKCDYFSLGLLILRTVVHAYNGYQNTSLEEVSDILKRANISQPTQNYQGEFDRIGNWVQGRFDDDTPWNEYELPVNGTSISLGTIQYFQSKDKKKGIQTPKITERPNCSWLPIYKFLEEVDANTYIDIVSHYVNGIDEVSRKPQVNISGDLVGHEISGYQLLGLCFSGRLDDLESDVDRARVYRRKRRSCAVVSAMRGYLPAQAICSQLLGESNYRFQKILEDNDMEWQRSAIALGFLLGWKFAYENPEEYALALSDFHQSGGYNTHYTHIAMEKESAYGPSGLVYEVQGPLEWLRNYLLHRAAALGQTAEVGRLLDNGCDINSLDINGETPLQRACMAGHASTARCLVQRGADLTLKSKVFGTVPLHWLFVFEPSEADDIADMLAGREKENLNAESNIEADAFHFPFKWPSGSPIAWSVLSNRYEAISALLRPGSSLDSIPDFFPSLPDWPEDVDSYDIRFNSRQNRNLFKAWIYKPILQYQHPIYQSSFRYVVKRGALEGLENLSSNRIDSRIVDSHGGELQTAVAEGDLDAVRELINSGADVNFFPGKRNTPLLAAIAAENLDIVKLLLDNEVKVDFSPDTFTGSPLQRAAKTGNMQITRMLLDASADVNSQSQSPYLTGTALYGASRLGGIDIIEMLLEKGADCSIIGGLYGTPLQRAACADKVPLEKVKLLLKHGADPNLRAGYHETVLQAAAFKGNPGVVKALLEADADPNIEGGHFWTALQVAVIPVNYQNHEVIDILLERKVDVNAVSGYYGTAIQAAASGGDESLVEKLLRAGALPNLRGGRDRTPLQAAAARIGNLKLVQLLLEAGADPDIGGGTNGKTPLEAAVASGDEAMVKLLLSNGADPNLLGGVDQVLLRIERQGREVGGMEQILLDWGARPSVEKIPPANPLHPLSWPEVEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIE9</accession>
    <name>A0A2T6ZIE9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1054499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIE9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIE9"/>
    <dbReference type="OrthoDB" id="3433692at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="292" mass="32840" checksum="A4679D973BE02563" modified="2018-07-18" version="1">MSSPNRSGIRNTHFYDATSPKVPLGGFYQGGSITEANFLSILGILIVTVGKPVRAQARVSGHIVTESEMPLALGDYDIYCDDPIQVTNEPWVQRLSSHSAAAMGTRFEHEIRTRDRKCVISGWSNSDIRLEIWAGFDATYIVPPEHESLWTQPDNDQWIKNIDNVTRSLKINSAKNGFLLNSAAHEMFNQYLIAVNPDDGYKIIVFCPDPFRYDGRILDPACRNPADPNSVSDQLLRWHFRQSILANMRGVGEPIFEHDFPPGTDMMDEILAGPNGKQRFEFEMAARLRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIN4</accession>
    <name>A0A2T6ZIN4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1131592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIN4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIN4"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="211"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1094"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1124" mass="120702" checksum="FD34B65123990CF3" modified="2018-07-18" version="1">MQLPLLPPSLTTKKPPPQWDPFTPMVTGLSKSACIHPIHTIVIIALLASTTYISLLEDSLFERSGNNWFGGAKRGALLNGSVRVGLGEETQWKWKEIGNQDMEDKSATELALLTLSFPVGSKFSVLVPANSSAITLPSDLSSAVYAIPHSELNTFVDSVAELPTVDGFDNQGRRRRWVQVGLDRTKRGWGERVHEFINTFIGLVKNAEPLDIAIMFLGYLSMHLTFLSLFMSMRRLGSNFWLATTVLFSSTFAFLFASIATHKMGVPINMILLSEGLPFLVVTIGFEKPIILTRAVLEASQKKARQAGSSNGAPIQAAVVAAVRDKGFEIVRDYIIEIIILSLGAASGVQGGLRQFCFLAAWILAFDCILLFTFYTAILVIKLEINRIKRHVALRKALEEDGVSRRVAENVARSNEWPRINMSEGDANDGGDVTAKVGDAGVFGNRVRDSSVGKFKVLMVTGFVLVNIFNLCTLPFRDNSSSTVIATESQAANVDVWALAGASLDSMISDKVPMVITVLKPIEYELRHLSVEVSPSATGSRGYDSNDSFDGPDLFVEGMGGKVVESLLKSLEDPVLSKWIFVALAMSLVLNGYLFNAARWSVKETGHSQEYEASTIANGSTDNALAPVVVERIVPVNCTCGGGAGTRHSIENGLPIGQETTNEVGRTLTECEEMLKEKRARELNDAELVELSLRGKIPGYALEKTLADTGRAVRIRRSVISRTPATMDKTSLLERSLLPHEHYDYDRVLGACCENVIGYMPLPVGIAGPLNIDGEIFYLPMATTEGVLVASTSRGCKAINAGGGAVTVLTGDGMTRGPVVEFPSVRRAGAAKNWIDSEEGQRRLKKAFDSTSRFARLQTIKTALAGTYLFIRFRTTTGDAMGMNMISKGVECALHVMSTECGFDDMFIVSVSGNYCTDKKPAAINWIEGRGKSIVAEAIIPAAVVKSVLKSDVDALVELNISKNLIGSAMAGSVGGFNAHAANIVTAVFLATGQDPAQNVESSNCITVMKKTVEGALQISVSMPSIEVGTIGGGTILEPQGAMLDLLGVRGAHQTNPGDNARKLARIVAAAVLAGELSLCSALAAGHLVKSHMAHNRSAPTSRATTPVPTEKAPPAGLTMTAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJJ8</accession>
    <name>A0A2T6ZJJ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_993615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000219">
        <property type="protein sequence ID" value="PUU75653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJJ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJJ8"/>
    <dbReference type="OrthoDB" id="2937326at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12523" checksum="7F71D378BC9B1219" modified="2018-07-18" version="1">MPAISPNVRACILQLANCYLLLSMCSTAVLRSTTEKCVVRRFLFALLLGDIGHVYLTYVAVGADYFLSPSQWNLLTHGNITFTVFLFLSRSIYLLGWGGNTDSRRLIKTKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK64</accession>
    <name>A0A2T6ZK64_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK64"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7343" checksum="344298E5F0C9A677" modified="2018-07-18" version="1">MGYLERQAFLTQLGQVARKYRYYTVLIVTASCTTPVMLYLIITCQFGENVFVSYDRLDVTGASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKH6</accession>
    <name>A0A2T6ZKH6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_992441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKH6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKH6"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="18686" checksum="9E7AFE6EFB65B6E7" modified="2018-07-18" version="1" fragment="single">QPNDTTWAHQRSIWAAWVLSYCRAHKIWKLQLSDALETELFYNRNLNRRFKQRDAVELLEYMATEGGIEWEGAGRATVIVYWRKPEEWANVIYEWVIIDNTGQKGSVLTLYEISEGDLTRNQEFHTIDPYVLRKALDILVKRSLAQVFGANEEMGVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLE6</accession>
    <name>A0A2T6ZLE6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_991181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000195">
        <property type="protein sequence ID" value="PUU76244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLE6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLE6"/>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="86"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="59127" checksum="449FD313E56CE9B6" modified="2018-07-18" version="1">MPSRLSSPMLSLDINHIAKVDPRNVDNLFSMWTIFSKCAESLENGRRLENLSWRVWNRETFCCDDTTTPNTPVPMKKPKRQDSEISDLPELSTSVESAASEYELSKESRSDAVNIRSSRPCLTRSDSSERYRGKEKHMTPVHLVKLMGDLDKSKSSAEDWISRRSFINTQISTSAEPSMPEQEITSTALVSPMSSTADHASPVGSESSKSSEQSNHSVVRGFSPGQVSSSYRSKAGMASESSPVKELVVAPKRARNNMWIIGSSPSSVSDDETDMDHSFSIRQGSQVSKLAEGLKMAGKKKRTSFRDEVATRTVYDEDTFSDDEENVSESAIEDDDDCSSDWESSTDSAQSSYTETAMFQRVESRPQLATRPSLLSTLLHEPKRAPVLTNNGSRSTPAIRSRNTSPSGPSLAASPRKESPLASKATAEVSHSKPIIVTTSNMHPPALSPRTTRRNMLATELTESLRKHLLWERQQKNTTASAVLKRRHTAHDVTKLNDYPQPNFMSGNKGNTSKNNSWNHYFETHEYHVAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLH8</accession>
    <name>A0A2T6ZLH8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1102417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLH8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLH8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="214"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="521" mass="56129" checksum="1F83E13812A28DF6" modified="2018-07-18" version="1">MSLAEKATKIAGELEYSPEQVREGVKEFLRLMDDGLQNDERDMTMIPTYVTNVPNGTEKGVYLAVDLGGTNFRVCSVVLNGDTTFTLTQSKVAIPKALMVSDSHSLFSFLAKQVADFVNEHHSDHFSEDPEHHLHLGFTFSFPVDQKAINKGYLIRWTKGFDIPDAIGKDVCALLQKEIDALGLPVKVAALVNDTVGTLMARSYTSPGKAGTLLGAIFGTGTNGAYVEKLDRVTKMTSASAKDVGEYDTSTGEMVVNTEWGSFDNALNVLPDSPYDRALDQNSVNPGIQMFEKRVSGMFLGEILRNAILSMKEDAGLFATSAIAEDSILNTPWSIDTSLLSYIEADSTKDFSVTKEQLQKDLGISASTISNDEAQAVKTLVHAIGKRSARLSAVPIAAIVIATGKLSPPDQPLIDGLNLKDLSLVEQGIEILKSVITGISLAAPSVNAPPPSIQDEPIDIGVDGSVVEFYPGFEKYVREALRDVPEFGERGEKRIRMGVAKDGSGVGAALIALAAKMQYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLQ8</accession>
    <name>A0A2T6ZLQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cnl2/NKP2 family protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLQ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLQ8"/>
    <dbReference type="OrthoDB" id="2311687at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="21592" checksum="F6395CC617BB87B7" modified="2018-07-18" version="1">MASTTKDLETQILSSFLLSRASLQDIISLRQFTELFPRDQRSNPQVKLLYRELQLLRNKTCERVKKNIKHEAALGIKQRSELEKKQRALKRVDDETMTAIELFGAAPMEPKLPLKELLKQMNSAVEDLDAEFNALDGECDRMLEELKSTIGDLSDLRYGKFAASDTDARIVRDLENLHDTCERALNPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM25</accession>
    <name>A0A2T6ZM25_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CAP Gly-rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_990422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM25"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM25"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="245" mass="27439" checksum="8AFC253BBF08E283" modified="2018-07-18" version="1">MSFSTTADIPVRVTSDNTASERRVTPSWTIAELKNKLEPVTGIPPSSQQLTLRVPHAPQPIPISSHDEENTQIAAFSLQPYVELHVADSRPLTARPDFADTTGVEKYVMPEEEYDKLQDSVLAWKKRNKLGRFDPNKEEKDQMELKRQYDTVEARKIVVGARCRVGASDLDRRGTIRYVGEVDEIPNGGVWVGVETDEPTGRNDGSVQGKSYFKCEAKHGSFVRPDRIEVGDFPVIDDLGDLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM94</accession>
    <name>A0A2T6ZM94_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1087847</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM94"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM94"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="371"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="644" mass="70240" checksum="30F0709DB964576D" modified="2018-07-18" version="1">MKPHRIRMTHSLIMNYRLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSKVTPDNMEQYSKEQGKYNVGDDCPVFDGLFEFCGISGGGSMEGAARLNRGKCDIAINWAGGLHHAKKSEASGFCYVNDIVLGIIELLRYKQRVLYIDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDIGVGAGKYYAVNFPLRDGITDTTYKEVFEPVIGHVMEFYRPDAVVLQCGADSLSGDRLGCFNLSMAGHANCVEFVKKFNLPTLVVGGGGYTMRNVSRAWTYETGILVNQKVGPNLPFSDFYEYFGPDYELDVRPSNMENLNSKEYLEKIKIQVLSNLERTRHAPSVQTIDVGKGLTEHQEEQDAMLDDIDEDGPGMDTRQTQRQWDCATEKEGELYSDSEDEEITSSMGVRKTGKKGLRNARDWKEGGSGTGSGNATPFTGPGGSDNASESAGGNTAKGSGATSKRDGQGRDLTEYDEELEALRKETEEETQPDNDGDVEMGGDEQPSPSAKVLTDEAADEEMIDVPAQPSTSSTSKTTKIDPVPAAESLAQAKPESATTDDKIKAEASEHSKTDAPAKGPSSGAAKPSESSIAEAAPEGSNPTATDRHTSKPPFAADEPVSSAAKAPASPAETSAKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMB0</accession>
    <name>A0A2T6ZMB0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1087881</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMB0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMB0"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="6">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="193" mass="22281" checksum="ECB302CFD8B408A1" modified="2018-07-18" version="1">MRIFQCHFCSGPIYPGHGIMFVRNDAKEFRFCRSKCHKNFKMKRNPRKLKWTKAFRKAAGKEMVVDTTLTFAARRHVPTRYSRDLVAKTLNAMQRVEEIKARRERVFYKNRMAGNKQREREANKKLVEENQHLLPKGMRTATEAAAEAEVEESMALDSSEAEAEEEEMVKVKVPVKAAKRKQTISGGDGMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMG0</accession>
    <name>A0A2T6ZMG0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMG0"/>
    <dbReference type="OrthoDB" id="5427675at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="18928" checksum="2F0B44BCA984978F" modified="2018-07-18" version="1">MDFAILVGRKTITKPIFSKAIGCDILKLVYLCNSFRIYPGFEPLRDDVVETKTKIDAVLNQASWKIGEGACADYDYENTFQRKVETPMQVHIVSSRDVAVLRSKEWFHLDEPDSERLGKALTSRLSCFIRFRDEKVFSAQLKLWQYLFTRSNYGGISQQRVCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMP7</accession>
    <name>A0A2T6ZMP7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1087603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMP7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMP7"/>
    <dbReference type="OrthoDB" id="15688at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008111">
        <property type="entry name" value="RNA-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45894">
        <property type="entry name" value="RNA-BINDING PROTEIN 8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU76768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18546" checksum="373B163F03242E0C" modified="2018-07-18" version="1">MADNTEMDLDEVPPVEENEVSSKASSNPKTAAGAFAVRSIEGWIVLVTNVHEEASEEDLQDRFGEFGDIQNLHLNLDRRTGYVKGYALIEFSTLSEAREAIAATNNTKLLEQTIYSDFAFVRPPPTPHNSRGGGGGRRGGGGRGGSSRPRSRSPGAKDEAAPSRSLQDRITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMQ6</accession>
    <name>A0A2T6ZMQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1028216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMQ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMQ6"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="524" mass="59516" checksum="4F9CDC47BFC3B805" modified="2018-07-18" version="1">MDAVIDNDTSLRYGGLKMAVEEVLLKRQVNPGVAIGGLVLWMFVWVAWKSYSLRVKVDAVGVSPGLFGGWRAMFGFFPRGNDWIAEGYKKFSPTGKWFQIPSVARYMILPTSPKILEEMMAEAENILSFNEALADKLAIEWTIHPCIKHDRSHVKLIQTKLSQRLTTILPEVMDELVLAWEENANVGKEWTKVQISDMMLQIVARTTNRMFVGVPLCRNQEYLDNVIQYAGKVMMMGSILDCLPRIFRGPLTNPLMKKSYHYAIMRKHVGHILRERKEKMRELGEEWKDRPDDLIQWVLDFAVDEKASSEEELIARLLMMNFVSIHTTSEAILQTLYDIGSHPELQPPLHAEITEILSKDGMCKQSLTKMKKLDSVIRESQRLSPITTVTMVRKAMAPHTFSDGTHIPAGAWMGAPAAEIQRSNFIPNPTVFDGFRWERMGVENQSSGKAGKYAAVTTSFDHLVWGHGKYACPGRFFATTVEKILLSHIIERFEVRCPEGRPKNKLFGMACIADPKGVIELKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMU0</accession>
    <name>A0A2T6ZMU0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000174">
        <property type="protein sequence ID" value="PUU76805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMU0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="20445" checksum="29856D85042ADA9B" modified="2018-07-18" version="1">MCSRKDWTNSRVAIAHAACVGIESENAGRQHVRFWNDYHVGNGDAGDGITRGGVGNLVAKSLIRRATVLVILQQRNRRWLKDGAARAARPYRAALASSRSRRGDLSPDRNTQKQEQRWQKVCPHCIGKCRRTTYKDSDGKSERKEFVEGLNVSSLPDTRNTSENKVSRILIGYCRSLKTCIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN14</accession>
    <name>A0A2T6ZN14_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000174">
        <property type="protein sequence ID" value="PUU76804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN14"/>
    <dbReference type="OrthoDB" id="5488585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="21852" checksum="E35F5E8C37B06386" modified="2018-07-18" version="1">MTCLDSMGVWDAVTGKTLKPNGTDTAAKFSCIHLCPHANSFLLFNIYRASEKSSKAPITLAKVREKFNKNTPMSLHSLLMSIITLRYSNKHEIAVHIEKHDELWLPPLEQTSEATSWSRDLDSISKDTLEAALLLLVNSGVTNGAFFPTSLPNTLNNVVDNLTTKGTAIYSQVGIKLLDLYPAKQPADTNTCFVPVSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNE8</accession>
    <name>A0A2T6ZNE8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_988471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU77011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNE8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNE8"/>
    <dbReference type="OrthoDB" id="3256520at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="237" mass="26299" checksum="5B507D393620F08D" modified="2018-07-18" version="1">MTSPSKIFAFDLYGTLLDTASISTALAKCLEVDSQDATLSHKITADWRRYQLEYTWRLNSMNYYQPFSTVTHISLTHALTQHLPTYKPSATTITSLLATYNALTPFPEVEKTLSTLTQDPAFSWVIFSNGCHAMLSATIANSRVLRGARCVSVDDVRRFKPDPETYRYLLEQLGREGDPASVVLVSGNPFDIVGAGKVGLETVWVSGGADWCDGLGRPRRVVVGLEEIVDGVRSWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNM9</accession>
    <name>A0A2T6ZNM9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_988104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNM9"/>
    <dbReference type="OrthoDB" id="5358829at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="627" mass="69766" checksum="7009066BAE82F105" modified="2018-07-18" version="1">MTGIAPSVGWDSMDEIDLDYVTWSLPRSEQGERRGKTTKVKIIPEELFTPGAIFVKLMGGSEGAWAKKRCANFRSTISTRCVRDMKREYSWKIYNVCCNPETGADAHYVRIKFVDEARDCYFALYVTALNGVAAKRFLQGPKEDHARPFGIGFDSGIASKERLYLISNCSKQTPYLRRVSVKFEVKQDGSWKRSDEDVDRIGFATYKSAPKSAIWESSSPETIAFKGDPFLRFARVTLRFGKRNERTILDMGKSFSPVFSFEKQSASITLSGVRVRTCDDSQSTKPIQAEVRLIFTDKEKNRSSFLRSQTRSAAVGEAEKALVLFKKSVELSGDNSLALEDSLEDDAIFEMNIADVVSKEFSVRLKGDITSERKNIKGVFKGSKLLLVPCFASNGVHLVLQSVDGEYVLRQYVPSPIQFISSITESSFAGPSISMLRRTGENIEREGSGKITYMFENGETDAANVVENVVSILEKLHTYQTTPPTTARSAQSSTRFPQMQSPQLLTPPQSPPRKLSTFQRHRSRVLEWASPQPIRTPPEDLSTIDEASGEYLMAPAPGPRAAPSHSSTRGGDISADSQHHILRASTPRSAAYTESIYSARSATLKRTLQSMEESGARTPLPAMGRMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNN2</accession>
    <name>A0A2T6ZNN2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1027707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNN2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNN2"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="517" mass="59420" checksum="863D54974A20984A" modified="2018-07-18" version="1">MALDAVMSYVQEQILPLSKGTIAAIVFGVWLLYRIALVFYRLYLDPLSKFPGPKLAAATSLYEMYYDIVQDGTLVWKMDELHRRYGPIVRISPHSLRLRKSSAYHEIHRMGTPFIKDIRFYHLFGVPRSMFATIDVNLHRQRRSLLNPMFSRKGILDLEFLIKEKIDILCRRMREYEVQDKFLNCHRAFAALTADIVTEFAYAKCYNVLSTPDFASRAFDSYDTQHEVFLVLKHFPLMAKVMQALPFWLLVRLMPGGAGFAELEVDAKANLKALSTRMRTGKMEKNPTHRTVFGEILAQHPDPENADPTEMTNEATSIVAAGIHTSRWALCTGLLEVARDPLIQMKLFEELKTASPDINAQLSYLDCEKLPYLRGVILEMLRLSYGVIGPLPRRVPKTGAVVGGYHLPGDSTIEMDNYSLHHDEDIFPDSHRFWPERWQTSESKQNEKFVNAFGAGPRQCLGINLAFCELYLTVGTIFRRFEIDISARGTERMKSKEHWMNILRDEPLKCKVISRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNP5</accession>
    <name>A0A2T6ZNP5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_198248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNP5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="9682" checksum="386643EEB1374C37" modified="2018-07-18" version="1">MKKGKQDNDLASDPIQDNRRKEIFENRILLFFFLSSFFFKHEREYGIFVYPALSHPPTVCRPNFFFHKSQHPSFHCPMGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP31</accession>
    <name>A0A2T6ZP31_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1128509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP31"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="52" mass="5863" checksum="72CAACD4D176224D" modified="2018-07-18" version="1">MKSAILGILKHHRTALITAIGGGGIGYCQKIYDKDERIKDRLHQEELLEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP55</accession>
    <name>A0A2T6ZP55_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP55"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP55"/>
    <dbReference type="OrthoDB" id="5418922at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="210" mass="23759" checksum="9F86BD6ADEFD5D7E" modified="2018-07-18" version="1">MPTSSQTSPGQAQHQTTPNPLIPLQLASMEAARVVWEMLGEEHLENFAVVGGAALLFYGSTIMTNDADLAITGDSYTKFLNAVKEDRRFSEGFFGKWEYWSSYDFMVEIDFINKNGDGDYLHELRGYSLIDGIPVARLVDLAIGKGTAWVQRKNQKDFTGLKYAVMMMAQRGLDFKGLDEQAKELFDDITMKLMDSPEGRQLLQIVRRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPY3</accession>
    <name>A0A2T6ZPY3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heat shock protein 9/12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_986569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPY3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPY3"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2440">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002590">
        <property type="entry name" value="HSP9/HSP12_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="9690" checksum="C1123591734C8CAD" modified="2018-07-18" version="1" fragment="single">GRKSFADQATDKVTPESQKPATQRVGDTASGVYDRAAGALQPDSQKSTTQQASDNVRSGSDTASSESKGIAQSVTDTVGSATQGLKDTLGGATGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQD0</accession>
    <name>A0A2T6ZQD0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1085684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQD0"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="235"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="409"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="661"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="775" mass="84811" checksum="D5E307D04A4B3CC1" modified="2018-07-18" version="1">MTKVVAVPMKSKFGGVNHEENFEDTTKPKQPLKRKLFKTKWFPILLVALGYFVWLAVDYFHHRYPQSQSRIQLPGKHQNDDYPFIPCSEKIGPPPTHRRPVPGRPGLTLAEQETIITESISNTTISQWSYYYTHGKHLAGTNKSTAEWTRDKWIEYGIPSHLAEYEVYLNYPVSHSLSLAIDGEEEFVAGLEEDVLPEDPTTGAKDRVPTFHGYSKSGRVEAEYVYVGMGGKRDYQRLVDLGVDLKGKIALAKYGGAFRGLKVKYAQEQGMIGVLMYSDPGDDGDITEGNGYAAYPAGPARNPSSVQRGSAAFLATMAGDPTTPGYPSKPGAERRDPSEFIPSIPSLPLSFKDALPFLQALDGYGLTAAEVDRSGWTGGLNVSYSVGPRPGAVINLSNEVDYTYAPIWNTIGIINGTIEDEVIVIGNHRDAWIVGGASDPSSGTAVLIELSKAFGELLEQGWKPKRTIILASWDAEEYGLIGSTEWVEEFATWAVPNMVAYVNVDVAVSGPHFHLAVTPELFSLVEGTIKDVPSPKAPGKSIYDEWVADRGPSRVRVPGTGSDFTAFVHTSGIAIIDLSFKRGPNDPVYHYHSNYDSYAWMTRWGDPYFAYHSTMAQIAAKTVLRISENVLLPHNVATFSTALQFFLSDLKDEITIVGITLNVSPLEAAISRFMAAAGDLMAIKEALEPGEWGGEQEAIVNERLGKFERGFIGDGLPGRVFYKHLIYAPGVETGYGATTLPGITEAVRVGDVKEATKYVGITAAAIDEVAKFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQX9</accession>
    <name>A0A2T6ZQX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1101645</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQX9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQX9"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="512"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="145"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="20">
        <location>
            <begin position="440"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="756"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="19">
        <location>
            <begin position="888"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="589"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU77891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="971" mass="107091" checksum="807AF19D510CDDA7" modified="2018-07-18" version="1">MTRVKSILGFNPLSVTLLAVITYVSLFSALLYIDRQPPAVAKKGELDYWGVDIEEAWSDLEVLTREFHPYNSRPNDDVRAYLLERIQEILSRNGVAGFGNELHSSGYGYSGTVDLFDDGIPGKPGSNVTFVGAGQDLTVYFEGTNIIVYIHGELPANELSPVLVSAHYDSVSTGYGATDDGTAVVSILQIIKSFTRPESQGGKRLKRGLVVLLNNGEEDYLNGARAFAMHPVAKLPHSFLNLEGAGAGGRATLFRSTDAEVTKYYKKAKRPFGTIVSGDGFKAGLIRSGTDYTVFVENLGMRGLDVAFYQPRSRYHTTEDDARHSSKRSLWHMLGGSLATLRAMTSDTGKVFDSPNGSAGEGHDAVWFDLFGRAFPVLHLHTIFAITITLIVVPFVVMVVAMWALGHSDKLYFFSNTAYTPPPPEDSIASRTTQGWRGVLRFPVAFVAASASVVGMAFLIHKFNPMVVYSSQYSVWICFLSTWWIIAWVILRGADAVRPTALARGYGFLEQWLLWLLAMIGVAVTIGESHLGSGYWVLVFYSGIFISAFISLLEMTALQRKSEIKIVVSGGGDQTYPSEEHFQTGASENVSNPVVNEDDDANEHATEETPLFRGPNRPLSFAPHRNPRFGNGDHESGDILVEEKDEAVYGGEQGWSKDLPSWTWVLQFLMTVPLQLVLAGSVALLMGNALAQTGADGSSMLTVLLGFGTFSIILLLPLAPFLHRITYHVTLFIFVIFVGTSIYNLVAFPFSPDARLKVYFQQTVDLQTGENNVHLVGHPDYVDRIVSEYIPSVKGKAYLCQADKLKPGLRRCSWKGIAPRVVPQAPSGVPPEHDFSDWISYNVTKTGDGKATITLGGRNTRACKLLFNKPLAKSPTLGDPIPGFPNTRELRLWSRDWERGWSVELTWEKGEDRREDEKSNSRVIVVCLWSDGNKVSDEIPALHEIRRYLPVWAIASKLADGLVEGSVPFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR11</accession>
    <name>A0A2T6ZR11_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1085205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR11"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR11"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="405" mass="44600" checksum="44C9326F8DB8E11C" modified="2018-07-18" version="1">MLLGVMEIDVNLRDFSGWTPLCHAAMLGKERVAQILLEDERVQVNLGNKYSETPLTMAASRGHGEVVKLLLKRPDIEVNSQDQAGRTPLSSAIAREQIPVVNYEEVVRLLLEDKRTDANLPDTALKTPLHHACENSKARIVKFLLAHPSINPNAQDSALSTPLSLAVRMGHYAGAESTVDALLSDSRVLVNLKNQDELTSLHLAVEYAKIPVVRRLISDPRVDVNSRNLTLQTPLHTAATPTLNFDQDEIIETLLARPDVDVNARDQSGMTPLSTALRAISPAWPIQVESLVEIFLKCQRVDANLLDNQGKGPLHFAVERGGDGKALEMLLKHEGINVGVKDLERRNLLEFAEAEESSVTVKQILRECLGREASRDEGRRGKGGEEEGEEEGEEEVNGEPREVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR84</accession>
    <name>A0A2T6ZR84_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1127492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR84"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR84"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="65"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="608" mass="67687" checksum="CAA161C65DB4C557" modified="2018-07-18" version="1">MLNFRKKLPKWTVLLAGGNNVGREGGQEVTSKSSCLELLALGSESTQERLKSFSSAWKPAWYTGWHAGVLACAASAVVVLIINVSLTIYAATNPRYSIEGGIGTLYSGSCDKSKTIGLWIHLGINALSTLLLSGSNYTQQCLAAPTRKEVDAAHARRKWMDIGAPSVGNLSKIKLERTLLWIAIGFTSIPLHLLYNSAVYTSLGANDFFITVVTSNHFEKGGYKNTTIVPMDNFDSLIAGYNVSTGRYKDLKPLECAKAYNTDFVSDRRNLFLITKNSSNATHNNTVLDMDCISSSGTAPTSWMCIDSHPSGRRCDTNKLVANLTSGLPWRIYCYKAGVVEIAGCKSEITDGKCKVQFSLGIMIVVICCNLVKACCMITAVVRSREPTLVTLGDAIDSFLRVPDSTTKGMCFADRQYIARDWKLGRRARPTKWEKNGVQRWWTSPGGGRWVTCYIFFSIYTFYMAWFLVTRIQSERKIWSMDLKSMWTRGLGKVNGVSLLSSLKLSNITLTILISNIPQTILSFLYLTYNSLFTGMLLGHEWSLFSHHHRILRVTSPRPGQRSTYWLQIPYTYAVPLMTLSGLLHWLISQSIFLARVDISDPFGRAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRE2</accession>
    <name>A0A2T6ZRE2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Manganese/iron superoxide dismutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1025922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRE2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRE2"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="123"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="272" mass="30709" checksum="8B256C1B4A702D8A" modified="2018-07-18" version="1">MSVPLILRRQILRAFSPLPRKLPTFYKPRSVHSMPVISLNEDVPGLFSKQAFKTAWTDYQNHLVNGLNHFTAGTEFDGMDAMDIAVSTARQPDQASIFNYASQAYNNHFFFQGLCKGPEKMTDQFKAYVNSTFVDVAALKAELFATANAMFGNGYVWLVLDQAGNLRILCTYNAGTPYGASHRRQDIDMNTGLRLGSELSPYTSAIRHATKGKTGGWVFPVLNVNVWEHAWLEDFGILGKKDYLMAWWEHIDWLVVQNRFPNKGAARMPMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRP1</accession>
    <name>A0A2T6ZRP1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_108274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRP1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10718" checksum="C8A67B181380B09C" modified="2018-07-18" version="1">MWISSGFVLRSSYLSAKLGSYSIQPPCGNDDASGFISPTYFRLYFILPVSTLFFSYIHLLFLPLISSRIGSDPSIHPLLILCFMQAHAKFEYQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRU6</accession>
    <name>A0A2T6ZRU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_100360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRU6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="125" mass="13778" checksum="5EBDD5130DD97E15" modified="2018-07-18" version="1">MARRLGWREGGRVFSFSAHPFHYNSSSSLVFSSPSIFVPSTTHPSIRHPSKKPPPSLQNSKGPKKVVEGRSQERSQPPWHFPTPPSKPLEDKPMINPKSSVTQNRPVPSSAFGGGKGRSGSYTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRW8</accession>
    <name>A0A2T6ZRW8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRW8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRW8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="315" mass="35311" checksum="D8603D937E7A7B18" modified="2018-07-18" version="1">MSQRGSLRSTPLGSEYSTASLSESIREYRYENGRRYHAFKDGKYPLPNDEAEQERLEILHHIYSLLLDGKLFRAPVGDKIHRILDIGTGTGIWAIDTAEAYPSAEVIGTDLSPIQPSWVPPNVSFQIDDAESDWTFARDSFDLIHIRHLNGGIKDWEKLIKQSFVALKPGGWLDVAEYEMRLKSDDGSLPVGSNLLRYYDLVNEAADKLGQEFKIAASLDKVILGAGFDKVTHEEMKISLGTWPTDKKQKDIGAYMLLIAESGFEAIGLALLTRTLGMKVSEAEELIAGAKKESHSKKIHSYNPQHLYYAQKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSD0</accession>
    <name>A0A2T6ZSD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000120">
        <property type="protein sequence ID" value="PUU78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSD0"/>
    <dbReference type="OrthoDB" id="3200925at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="130" mass="14593" checksum="50500B5588B6B19B" modified="2018-07-18" version="1">MSDHSSIEWETVTSRNGVSFRIGREKTQGEDVAPASGKSFSIEVNWPVGSGWVKTTDEVRTTAGITQYNLSTTPGGSIFQYFLQFNNTDTYDYEFYDETGDSYEVNTFTTRTHSVQYNSDKPTIVRITGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSU3</accession>
    <name>A0A2T6ZSU3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1126612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000116">
        <property type="protein sequence ID" value="PUU78561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSU3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSU3"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="11"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU78561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="354" mass="37713" checksum="83D46372DD319D80" modified="2018-07-18" version="1">MSSENPSFVLKSVKDLIFEGRPVPRIQNPTDVLIRVNVTGICGSDVHYWQHGRIGDFVLEAPMVLGHESAGTVIETGPKVTSLKPNDRVALEPGVPCRCCPFCKAGRYNLCIDMKFAATPPYDGTLAKYYVLPEDFCVKLPENVSLDEGALVEPLAVGVHVARQADVKPGNSVVVFGAGPVGLLCCAVAKAFGATKVVAVDIVDSRLEFAGRYAATGTFNAMHSKDPNVNAAEIIKRFDLVFGADVAIDASGATPSINTCVHVLRTGGTFVQVGMGAAEITFPILKLCAKEITLKGSFRYGPGDYGLAVELIASGRVTVKDLITGRVKFEDAEKAFEKVRNGQGIKTLIDGPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSX7</accession>
    <name>A0A2T6ZSX7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1048150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSX7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSX7"/>
    <dbReference type="OrthoDB" id="5373194at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF2">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN C1F3.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAT" evidence="2">
        <location>
            <begin position="166"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="305" mass="33955" checksum="159DECBD6FB5F3FF" modified="2018-07-18" version="1">MLSRRLTSSHHPRSQMLQLAQLISNACSSGRSSVRARAKVLEYVREKGGNTAYEAAMALIGFIASGDDVAVQAVELLRYCSHADVPFLTILSQPPLLQPLLILLKERTLHACLVELLTTLEAAGIGLPYVSTVRKVCDNLRAKGYELSGVLYMKMYSKHELRHRRELAYSARLQACLRRGSKEDLREANELIKVLAGDHEARGLQAGEEEVLVSEMIAGVREQISALEGALEGKIRREVKYDGFVNKLAHLLQAEKKKIDEIEADGDLTVGLREVKEEIEEVLQKHKDLVVGEERRIIEGVLVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT71</accession>
    <name>A0A2T6ZT71_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease-III-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1048003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000110">
        <property type="protein sequence ID" value="PUU78678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT71"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="187"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="273" mass="30647" checksum="9E31B727D83EE565" modified="2018-07-18" version="1">MASRSSRKASSLITSSPTLQCLQRRTRPSALLPPPRRHIQTAAEGEETAGYLPPRKITHARPQRRAPFPTRNPRPFAVNDDPARLNEVYTTLLGRDMGLTDKVKWQAVTHKSFDHGRQPFNEKLAIYGKRVCWLHASLHLLNGPPIEEKKTYKSPNFVSSLDGMPYREPEPFLHRDYKSLVSIRESNIRAILDPGKLAAIARLARLASVMRWKPKDNKDLQGSGQALVATQALYAIVGALALQRGGDIAGSMVRERLLSSIDWLVEKTKDMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTB1</accession>
    <name>A0A2T6ZTB1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery associated TMA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTB1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTB1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="6850" checksum="2963C3CC0F4219D6" modified="2018-07-18" version="1">MSGRAGGKAKPLKQPKKEKKEEDEEDKAFKQKQKEAAAAEKAAAEKARKKGPLATGGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTT8</accession>
    <name>A0A2T6ZTT8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTT8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11488" checksum="7FA625CB028302A6" modified="2018-07-18" version="1">MKTNQTNHHHNQAYTHEDQDSPLPTNHSQHFPLARTVRDFQSGHNRNPPINLSYHRSRAKPSNTNFRLTCAKILYFVSRLPKLIVSWGGTSTGLSLLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUB4</accession>
    <name>A0A2T6ZUB4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1082675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUB4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="13964" checksum="B3AA13A5BD25B3C2" modified="2018-07-18" version="1">MTFFKGVKLIRDMVGMGGGNENKNNNKNLIWIRIRITDFRKGFVLCNGGGGRRGKGRRWDWDWEIGGLGDWELGLRSGLGIGNWELGTVRRFGTAQYIRRYRIMRSIICMCSHPTVIRQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUL1</accession>
    <name>A0A2T6ZUL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUL1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="539" mass="57701" checksum="B9973F9D62121388" modified="2018-07-18" version="1">METDAPSAPEGNTETPVSRTGAGWLYQITETIGALHDRFGMIADSLLIISDTLSKLNEPSKEREPEKENQNTIHKATEAPCTMTPYLTTQDSQRRGTRLVESAQNGQLSGGARVGVEEESQDITTATTASTQTQTETQVLAPPAAHLMSLPTTPTPAPSKESQCRKARHISFLESKWGAGWEKTIDSQSDHPSLLSEHYLGNMVKLASGGMTLLDAKRILRHVIEMRVSRPRKGVRTREIVMAGDIQKVVSAIAAVSHSHNTQPEPYTTAQLIAFLGATGRTIQRTPSITRGAPPPSQVAPSQRATFPTRDMQETGGLAATSPVAGETVAGGQIASTRAKSPALRPRAGAGVTKKTGTSVQVVVNARARAVEDKNITTTTTTTTQTKTQTPALRPVHNTSLGHPKISTNSTPSSIMSMGPAATDKTTKVPHTNTPRRKPQGPGSQSMRTTESAQIVPASVTKKEKEQTSAIKVEVKKEVKKEEESIDPAIKVEPVVLKPRPGTGISKRRGSGSGGRSPTGRRWREGGPTNGKKTWDSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUX9</accession>
    <name>A0A2T6ZUX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1192746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000096">
        <property type="protein sequence ID" value="PUU79273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUX9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUX9"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="51"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="346" mass="39094" checksum="39D17CAD1908A73C" modified="2018-07-18" version="1">MPPTSEYKWARYLPVADDYKEPDLEDYNHVEPSTRVDRTKELTFLNGDSEITEISPEIGTEIRGVQLSALTPPELDELSLLLGRRALLVFRGQDFRDQTLEKQKQIASHFGRLHVHPISRHVSGSREHLVFYRNKENDVFRSGAAQNRVSTTLWHHDQSFECHPPSATILTGLTIPSKCGGDTEYVSMTAAYRKLSPSFREYLETLTALHSGVEQAEESLKKGGSGILRRTPIETVHPVVRVHPGTGEKAIFVNRAFTKHIIGLKVEESEAILSLLYDLIAKSTEFHARVRWEDATVIVWDNRITNHTVISDFSYDKGDIRHHFRLTATGERPIPVPGKLSPEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV83</accession>
    <name>A0A2T6ZV83_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV83"/>
    <dbReference type="OrthoDB" id="3558706at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="38723" checksum="42C93C82C4C0E45C" modified="2018-07-18" version="1">MGHTIHKCDRVISGNLPKSGRRHWRQFRFTVTYEDLAFCLPLELYASLNVSSALSVSPETTTKLWERAVRLRTESKSDQGGWVSFVQDIAPYILAENLDKKWESGDRIPEDLTIAPVQANAVRVVFLCVATGMKFSGHSPATGELSMSRKVGTITTVTNESLEDIRMLSWVVNQGNGMWANAVFGKVNDRVVGRGFPDFTMFLKVMEGFLLSHGWLEGSRTDSIGGAAEFMAVATMDVNVAISPTCIHAWCAHFVEVIVKAHLYEIQGTEPVINTPGFCHVQGNIIDSRRLIATHPLGSAPPYQPDPETLNTIIEPLQPFSLANHGLLSSGTCTEETEHPSAFLTPAADMSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW13</accession>
    <name>A0A2T6ZW13_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1081227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW13"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW13"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="86"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="479" mass="51907" checksum="4EBA40A10C9F7164" modified="2018-07-18" version="1">MDKERGPASSTPTLTALDGDYKPGESDSGRERYTPSNVSRMSAGKGEECGDDVGIAPAGEGLENLEKQPTTLSIHHPSSFPDGGVTAWLSVLGGFAAMFCSFGWINCIGIFQDYYERNQLKGYSPSTVSWILSLETFCMFFLGPIVGKYYDSYGSRVILLLGTFLHVFGLMMVSISSKYWHFIICQGIVSATGASLIFYPALGDVSTWFFKRRAFALGVMASGSSMGGVILPIMIERLLPRVGYGWTMRIAAFLILGMMIIANLTLKSRLPPKGWAPLKLSDFLKHFKEPVYSMSVVSAFLFFFGMFLPFNFIVVSAKRNGMSTSLANYLVSILNGVSVFGRILPGWLGDKLGRYNMMIMTTGASGILVLALWLPATGNLPAILFACFYGFTTGAFVSLAPACLAQISDIREIGVRNGGMFAFVSIAALTGVPIGGALVDKYNGGFLGLQIFCGVTLLAASICWALSRWIIAGWKITRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWA6</accession>
    <name>A0A2T6ZWA6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1022949</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWA6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWA6"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU79767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="35368" checksum="91D5A027A8341C61" modified="2018-07-18" version="1">MTDISSILQGGYHHPLTRKWQAKAQLTKSMLVYPIFITDNEDEETPISGFPGQKRRGINKLIPFLTPLIAKGLASVILFGVPLATGAKDPSGSKASDPNGPVILAIRVLKNAFPGLFVMTDVCLCEYTSHGHCGILNEDGTLNQQASVKRISAVAVDYALAGADCVAPSDMNDGRIKAIKEGLIAAGVSHKIMVMSYAAKFSGSLYGPFREAAGSAPSFGDRRCYQLPHTGRGLARRAIIRDLAEGADSIMVKPANAYLDIIADAAELAKNVPISAYQVSGEFAMIHAGATQGVFDLKAMALESLDGILRAGATIILTYFTEAILNEGWLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWG3</accession>
    <name>A0A2T6ZWG3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_790368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000081">
        <property type="protein sequence ID" value="PUU79825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWG3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWG3"/>
    <dbReference type="OrthoDB" id="10383654at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="406" mass="44481" checksum="B7FA9404B0AB1E68" modified="2018-07-18" version="1">MTASPSDSRQPSPRPSPRPSPRPSMEEGVRLLQQQEPHSPFRPDEELHFDFPPVVLSPKEITPQESSYSRLPRAPVRKMISVPELRDGQRGPGLQSNSSMYRQNSAGRPSPRMRQTSEERGKDNVGVGPEMLSKQIHRRMMEQEQSWGSPDGSSGGRDRLLRQKSMERGIKVGLPPGHPQGRRGMNGQSRRGRRNGERTESPTPGAAPPGLKMPLAFNSIARERGFTTGSPHPATQVLASSSVLEGDVSPSVTSRMAEQDNVRQMALEEQKEELEATHTTQTVEHTGAESGLKEDLESDSKGDEVPGYKDTIEPESSAQGNGQRSDHKEYDTSSAELTPTEEALKILQSKPVAPEPKSPTFLAVGDPSDTPQRNPAMANGVLPKDARDRYGWATLFLTGKLNANLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWS1</accession>
    <name>A0A2T6ZWS1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWS1"/>
    <dbReference type="OrthoDB" id="2151417at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38849:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015401747" description="Small secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="18914" checksum="3CBA3AE03BFE0A9F" modified="2018-07-18" version="1">MQFHLPSASILLLLLSTLATAAPPPLHIRLKRALTFRQYNDMSISAGPAGNAEAEALAVWTAGIDLSDLAAVAAADLAILNVERDNAENAETEAFNPAIQAASGAAAEALQCGKIKNKVLKLTGLAQIRRINLAQAQAASKDTASIQAALADTKKKLATNIAIDKGSAGQECQAVDFVGQTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX84</accession>
    <name>A0A2T6ZX84_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX84"/>
    <dbReference type="OrthoDB" id="5324744at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69304">
        <property type="entry name" value="Tricorn protease N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134703" checksum="DBC4BCE538C70E42" modified="2018-07-18" version="1">MSGTMLLTIAVPPAGEGGGGGPIEMHASDDEFNGNVLREDGAGSDLAQPDLFVTAKEMLWLLPGINGVVRNTLSRMQKAFAYNSVFFLKVVLDLQATYHSLSQPLPADVFLEIDLVLRVAEVLAGRMVKKDKDGVSPSRELQLRTLVSALSLLYQLRIGKLNNSAHAKLLKDISERDCDNRVKYMEDSGERVSNGDVEFLIRYACDLIRCMPSELPKFTEMSSQAIHFLFAAGYINQLEGATTPTALDKIWARITAPPSGWHKDVRHLYEGTAGAISLHHQAQYSNIGRASQYASSLAIEIAKSIVDKIELGLRAVAPSEKSDSDDEEDAGRGETEDLPSLETRLLVSGLLDLTGQLVMAFPECDEIVEDAKSLALKLIQTSDKKEFRNKAFEIIISTAAGCSEKEYYNMMRSLDLDIENMSQAGILPPTGEDESLRIEELKREKRDAMDRCEKRSFLYKGAVESMQRRLQGIRAAQSPSRISQTIDEVLHLAPWNEGIRFTTTSIPSSQHSQVPTLSSQAPTCDTNVSRTSTPTCGSALGPIETLLSPNSTTCKSLSSPTESTCHTLLSPVPRDDSPIESPVLPSLTPPSLTLHTTYPAPITPHEAVTPNLDTTLRFDGLDQLFAGAVFEEPELYDEHFPSEANVGKVDFELPIQSFEIEDDRSTFLLQTPVEGEDQETSDSEKSQPMNSPRISVYSQALVEPPPQSPTSIYPEPSLSRTPSGLTEASSLKRQSRASKLFSRRPFISRDSRRFHSLQLNKPLPSIDRETVLAENAPEPVLPGQPAQPVRSQSALEVRDDKMDYFKVRGAPLPNQYPSKYCLPALHPIPCGVEPVPAAANSSIEYESQPIESVFKVQCKESCFSTFISSDAKYAVYLSLHSFQVFSIPSPRENVLTKPKFHYRLGSTEGLRKAKMPWTYKAGAASDKYIVVITKEKVQVHDIADCKVIFTESTTGWENTCVAIGGDKIVVGMSKKIRDETQGLIRIYMMNAPTYQGLRCERVRDLHLPLNVRAILDAPHIISLTQDGNHLTCATPKCGYFFSWDISRVRVQDPYLISSGALKVTEGPGAETLSNAILFPDKRHIFCSTFPASTVEAEWGGSFTEPTSISSATPSHSPIRQVGLRVTHSAVAPLGNAAAFLTKSGLVWITPVTHVEGDNNLTTFAALHSKERMQGQQTPESAGRIAFTPEGDRLVAVDRKGKMLTLSFRRNCTPVVATKLEVGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXS8</accession>
    <name>A0A2T6ZXS8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_957843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXS8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXS8"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="58" mass="6499" checksum="7E181B526124B18C" modified="2018-07-18" version="1" fragment="single">NSVEHDDINVVAINDPFIEPKYAVYMLKYDSAHGNFKGEVSVNEANDLVVNGKTIKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYL4</accession>
    <name>A0A2T6ZYL4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial protein Pet127-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1113889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYL4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYL4"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000964">
        <property type="term" value="P:mitochondrial RNA 5'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013943">
        <property type="entry name" value="Pet127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31014:SF0">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION SYSTEM COMPONENT PET127-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08634">
        <property type="entry name" value="Pet127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="802" mass="91136" checksum="05A9F3D8251626A9" modified="2018-07-18" version="1">MLRTTLRRVQLSPRSAVSPFVCIFCQKKGPNLERRLTTKDVGQSNSVEPPPTTNTSASSLKKSVSVMDILKKDMLERKEGRNRKKSAKKAKAAEKKESKKARAAEKKEPKKSKAGKKMGVSLFQAEAAVARSPKKKKALQRARGSTMPGISLSEALEEKVGDIYKYEVLDPKSREIETIEREGQPEVARLSHNLDRVLFNPGVHYLQEPRSRVYNFDPYLQEIMPVTEFDFDAVASYIVSSEDHRLSSLAKELGKKYVGSTSSMTAVLSHFHFLLSQWRPLNFLGLSKTFRAEFKTFTQITRAPAAIFLRYKGNGTYAIDPDKEYDTDSVLSLLGRSMEKLLTTAPSNFESKYKKGSPRSEEESLIKGPETYHYSTLGDILMRSQLDAHDPRLPGTGMFDLKTRAVVSVRMDVANFHIGSGYQIKTRVGTWESFEREYYDMMRAAFLKYSLQVRMGRMDGIFVAFHNTEKIFGFQYVSLDEMDAAIHEDWDTGIGDQEFRLSLQLFNKALDNATKKYPEKSLHLHFEARDTARNPMVIVAEPMDEEEVERRQTRNKRDLADFLEALDKQMKGGEGTVPSFKDLEYQEGEKEAISFDEDEGVQKNIQQEEEADDEGVKDHGENDLQELEESESEEDGDLSDVEDVRDIEPNQGVRGSIEEDAVGALEGNPKADTGAIGLARVGNKKEVQELEKFPEMYVQLMYIRNYVNEKPVPRPTRLKEDDSWKVAVAIDELPPKPAYMTNIGVVKRRKRAIEHRMITEDDAEAGAYIRQLRNMSRAGRDWAKTQEEMFPGEPVLYKPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ05</accession>
    <name>A0A2T6ZZ05_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_974017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ05"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ05"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="6">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11165" checksum="E013DEE4A0E76AB5" modified="2018-07-18" version="1" fragment="single">IACAGRKTSIMSLADGVLKDSKGRTGCIAANRQFRFYYQPLQRDVLFSGGFSVRENGVLALGQDDVFYGCPCEEVWKPYDMRIADNCHPILQEIGKLIQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZJ2</accession>
    <name>A0A2T6ZZJ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1122812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZJ2"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="132" mass="14783" checksum="68008044A7104452" modified="2018-07-18" version="1">MRPALRLLRGGFLQRSIDEMKRNTFSVFKGEDITGDFADMEVHSFRHLDSLKSIKVFSDADTGERMVHHAKLIKKVGADCPPETQAVLNELAKTHAFTKVLGEEAASRGLKPEAVTQCISLVYDSLPTRPWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZL7</accession>
    <name>A0A2T6ZZL7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B9Z19DRAFT_667678</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZL7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZL7"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PUU80921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="485" mass="55700" checksum="5B4B44A39805EBD4" modified="2018-07-18" version="1">METKSRKKPHGENGSTNGSTVPKGLVGSDTATKDNLKMGSDHKVDNSGEFEFGGVWGTGLAMVFFPLLMWYMWVGQVYYDSQFPMLEKGEAIADFVGKVANLAYESAYPTKKAWLVYWGFLTYQGLLYVTLPGVWAKGNPIPHRDNVRLDYFCNAVWSFYFTIATVAILHATQILPITCLVDEFGSFLSVGILSGILVSFIGYFSAIYRGAQHRMTGRFVYDFFMGAELNPRIIDIIDLKMFFEIRLPWFILFFVSCAAAVKQYETLGYVTPQVGFFLLAHWLYTNACCKGEELVVTTWDMTHEKWGYMLIFWNMAGVPLTYCHGVLYLVRHNPSVYQWPIGANVFLYVFLLCAYYVFDTCNSQKNRFRQMEQGTLIVRKTFPQLPWQTLKNPTFIRCKNGGTLLTSGWYGLARKVHYTADFCQLTSLGLVCGFASPLPWFLPTFFIIMILHRAWRDTDRCAKKYGADWEEYKRQVPYLFIPYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZU9</accession>
    <name>A0A2T6ZZU9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED16</name>
        <name evidence="13" type="ORF">B9Z19DRAFT_972822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZU9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZU9"/>
    <dbReference type="OrthoDB" id="4139168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048338">
        <property type="entry name" value="Mediator_Med16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021665">
        <property type="entry name" value="Mediator_Med16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13224">
        <property type="entry name" value="THYROID HORMONE RECEPTOR-ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11635">
        <property type="entry name" value="Med16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med16 N-terminal" evidence="11">
        <location>
            <begin position="134"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="12">
        <location>
            <begin position="792"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="895" mass="99773" checksum="B19590756E240895" modified="2018-07-18" version="1">MENGFGVDDLFQDETIPRLSSRRRVDARLDELRLSGCNSKIAWSKVGSIAIINSAGTGVETRHLACNPEDGRWVLSNAYPIANVSRYHENQRLVHVTWNSGAELAVVDVLGRVSFYTVFLAVNHLTATRSQILDQDDDLSALVGFWWLPLEKPYALYRPAARQEDRNFRYQALSYKPFGPFHPIVNKVAAIGITRGGTVKMWYQDGQGRYQEVTAELEGFASLDDLFSHASISCSKDHAAVLAAYTLSKQLRVYRIVINWPQPNQPNQPHTVLPNPPTLVIKHLKIEDCACPADSSTHDVSRAQLTHLETLAPTPAPPDIHTAPGVLAVFTNKKADGEAFSVICRWSLKETPCTLHPSFDQMGVRRTSVSSPTISELYRMDDVVMDKCIIGVSQVTSGTVIALAFSDGSLELRDRYVSQLRDQSTNKNVVMNMMQAGFAFPPGEPCINLALSPNNAVAIRLGPDNDISLIIMEYINGPMEQNDNLEIACVALAHQHAYSCNNLINNDDLLLVAQKYRNPTFNNTFLSEAHRALNLKMDFATESPNERLFRNPLLQRCLSLQNSLDFRGERVNKRLSGKLAWATLHLRVASVAFALTFNNPQRQGQGRDASAASGSGSTSSDFDLRPEALQTLLGLVRWLMDIMSLTISDLFDLSKATKNHTSDLAYVRQKVISGNSPALFLALSSAPRALLRYNCRSLRGLETTAGKHLSSTLSTATDEETRATFRSLKVPIESCAVKISQFERIMTDIDGTIRAAYHNIPEAERAQAEKLLFVNNEIPPIFRVAVERLLNTTLPNLRNDLDIAKLFWHDVTWLGFHDDIASCEYRRRNRIDAIRKVVLPKDDDSSGAGGGKIRLRRCTRCCAVVEDIIPNKSPSQWFGSMQRMCFCGTLWMHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A095</accession>
    <name>A0A2T7A095_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_654024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A095"/>
    <dbReference type="OrthoDB" id="5450301at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="12582" checksum="1C082B318A4791E1" modified="2018-07-18" version="1">MDTSGLWRHLKLPRVDGRTGDEKDAWENLHKIELERLLATCSSRRRSARVQTHKRLGIAEFELRARGMGITEEVLVAQKVKIWEGIWVAKKNGEDIEYGALVLLDFIASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A125</accession>
    <name>A0A2T7A125_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A125"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H-type lectin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="60" mass="6603" checksum="F8E35559D64487B4" modified="2018-07-18" version="1">MSTTGSWITQDINSLDFGHTANLRIWVLAENVTPTGLTWRMDSWGDSIFYSAGVSILAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A197</accession>
    <name>A0A2T7A197_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1042979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A197"/>
    <dbReference type="STRING" id="42251.A0A2T7A197"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05234">
        <property type="entry name" value="UAF_Rrn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="27921" checksum="FDEC76C50E6F0709" modified="2018-07-18" version="1">MAKRKRAQTIPPLTSAADSAPGTCSPESTKGKSTKPPIKKPNATVYDAVASRVNYEGMISTGYTDMHGEFRRRSMRAVPADEVLARRKNAPEVIPYGEEMERVLPDSDLLIAIHQYASDFYEANGMGPASYRSMDETALLSVGVLLEEAVRTCLGKEGELALIDEEAFNPIDPYDARRQRSLAYSQSQREAANSKREEGRRKKRKKRIKSEDEAERVGAKELAGEEEGMVTKKGKKRGSRKKTKKHREKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1C6</accession>
    <name>A0A2T7A1C6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1099634</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1C6"/>
    <dbReference type="STRING" id="42251.A0A2T7A1C6"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000212">
        <property type="entry name" value="Stress response regulator/HFS transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="360"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="604" mass="67008" checksum="86AAC5D844123841" modified="2018-07-18" version="1">MLEDPTHRQTVRWSDAGDSFIVVDTNEFTRNILPNHFKHSNFASFVRQLNKYDFHKIRNNEEGGGNSYGHQTWEFKHPDFQMNNVDNLDNIKRKTPAPRKQVQQSEDGGVQQIEELNSQVQELSKVNQEMTNQVQRLASDNHAVIQELNTMQHVLQQHEERVRIQEEVINNIMVYLQKLDDEIKEMRPVGGNPSQKRHGNDGRPSAPVSPENSVTGPATSASGSREHLSTPLQRAQMLLNNHPEILDTNPALGRFRGLSQSGPSGAADYSDFGTVNRLAQSDQRPAELSNGIPTIPEDGSATFAISPGTTMVEPFPNGNLGYPMHPPQHENGNLGIRGRPAPGRKRSTPFVPPNWQTPPRVLLVEDDPTCARIGSKFLQTAECSVDMANNGLIAVNKLNNGKYDLVLMDIVMPQLDGVSAASLVRQFDSTTPIIAMTSNIRRDDINMYFNHGMNDVLPKPFTKEGLLNMLEKYLSHLKANEGQIPPQLNFNEHDNRIIEEQGNIMAKSGLKYSEPPSKSPQNAVLYGRPPTDTDGDPIGEAPSAVEDTAYANIIPGYLGDSTVPHPTDTFPSSEALAHGVRRGASEMDDSQQQLMGLDAKKTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A233</accession>
    <name>A0A2T7A233_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A233"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="207" mass="23600" checksum="CB33C0873778BCD7" modified="2018-07-18" version="1">MSIISVSPSVPRRVRLPRSADEWKPIINKIVPTCDIGGDDLNWKSKEAIKLENHFPEQIVRSVSPHCECCLIEYLRTRYYKGKLCVTDEQLSPFHTKRKYQQRIISQECDEVVNVFVPTTTGRQSSPKLQPACLPDSHHATMDDVFDPKCTSAKMEPLTFDTTRGGKKKRHLDTITSPNQLSPTWTPPLTLTPPNIRKMFLRGPGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A264</accession>
    <name>A0A2T7A264_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000040">
        <property type="protein sequence ID" value="PUU81755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A264"/>
    <dbReference type="STRING" id="42251.A0A2T7A264"/>
    <dbReference type="OrthoDB" id="5380296at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22143">
        <property type="entry name" value="F-box_ScMDM30-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="482" mass="54186" checksum="3948116555DA3847" modified="2018-07-18" version="1">MANMSVPVLPPELLHIIFANLKNHADIYSLCLVSKYFYTIALRFLYRRLKIPHRTSGKLVTPLHAVLTPQQQERLLRFSAGREDGSVRRSMKGSGSSKDLSDCGEFVREFEVAPLVGTAEEVSEIRKEIIESAIENMCYLESFAWNTSDPQGPRRTSRISATHRRASSTADYDIIYKILKTSAGTLKSLSLITEGGQAHYEDEILLFGGGVSEEPPEGMRITRLGRLESLTLVGRRITVKRLEVFTQAINFNNLRCLEIVFCDGEPGKGGERASEGENKIFPNLRTFRVKATQSSVTKFLQCFRGLQDLHYELECDPTDWTAPGGNRRQVSSIRISRDLLEAITTYHGNTLRRLTVLSFDQLKVIDEPGMKIITGKCRVLEKLCCPVLESSFSGQPAVTHVPSLTTFHLHLQTLVEESKAYEIIQKILKQISGLKTVRMLAGRDRTKAFAFRVCPDGVVESFPDGRFLKRGVEGWEVWGLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2L3</accession>
    <name>A0A2T7A2L3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_512632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2L3"/>
    <dbReference type="STRING" id="42251.A0A2T7A2L3"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72460" checksum="A5688472B73B7395" modified="2018-07-18" version="1">MADDIPQGLNDKYTHHVAIQISRQQNSQTVNDYLARNIIKIARDQPGPKTFILACKGLGRYPDDFLTEIFEEVKTRDRYDQVHGKSGLSESSAFGAPERATDTSNNLPGGLLLARKVDRSGGNGEEGGKKESRLGLDRLAKRIKLDLGADGEHEGNPEGKSGDEKVEFKKPAIPIRGRHIRERRIETPSHGPGLSQEALERLNAHRARRSGGGGEGGRDDRDDERRGYSRGSYPKDSRDYRDSSRYTPRNLRRQDPTPLRNVDVRDTERYANARPSTSRSSRFGNATPRMPNTFDRDPEDVPGINEEDDSALDRDWYASDELGHAFGDEYHNPFGLADNSWADQQREQALLEKKQGKRMSARAQQKMKDVDAWETNRMLTSGVAQRADYNDDDLDDEEEVRVHLLVHDLRPPFLDGRRVFTKQLDPVPAIRDPQSDMAVFSKKGSLLVKERRQRREREKQAQEATNIAGTALGKVLGIKDDDDGDSAAPTGGGKEETGGSKFAEHMNKQRPSEGNSEFTKSRTLREQREFLPAFAVREDVLRVIRDNQVVVVVGETGSGKTTQLTQFLYEDGYGKIGMIGCTQPRRVAAMSVAKRVSEEMEVRLGGLVGYAIRFEDCTSDETVIKCKFGNRYTDIVILLTWRLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A397</accession>
    <name>A0A2T7A397_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1121231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A397"/>
    <dbReference type="STRING" id="42251.A0A2T7A397"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="426" mass="46400" checksum="1ED4A1A21AB61B49" modified="2018-07-18" version="1">MAAKTEDLTELSNIISTSAKNYLSHVPTPPTLRPAPLVLVADEAIEAREKLLQACRKVISLVEGPIETIIGMAGAFYETTALKLACDMKLADNVPLDGSPIALAELASKTGAPEETILRVMRLLTFKCVFVETAPGYFAHTCGSAAIGAPGIGDLVGHRVGEGFASGPHTSDVLRENNFAAPEDSRKSAFSRAFNTNKGFFEYIYTDDKSMGTRFGQAMTAASGIPFNLVTIYEPLLSTPKGRILVDVGGGIGHVAIAAAQKYPNLKCVVQDMGTVVGEGRDRLPEELKDRVEFQENDFFKGQPIGGPGVYYYLKHILHDHPDPVCKQILSRIANAMDSSSRILIDECIMDERVGPEGDRMAIMKDLHMLAMFNDKERTEAQWAALLKSADERLVVERVWRAKKDNTGIIEVRLASGVHRAILAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3N0</accession>
    <name>A0A2T7A3N0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Soluble quino protein glucose/sorbosone dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1120847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3N0"/>
    <dbReference type="STRING" id="42251.A0A2T7A3N0"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015773485" evidence="3">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="4">
        <location>
            <begin position="43"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="485" mass="52460" checksum="FA11D72CD9B01F0E" modified="2018-07-18" version="1">MFKVKILLWVLIVFRQAFAVPGDPAMDHICVTNGASLAYPSPSIVGGYTYQLLTNQLRHPRNLVFDPNGNLLVSGDPDGIFVLRVRSGEGGCVIYDGKTLLGDTSGLKLNHGLALSKDGGTLFASSADIVYSWKYNPRTLSIDSLSRKKIVTGMDSDGHVTRTLLISRLYSDVLLVSRGSNGNLDMDAKDLPKGKSMIKAFSLSKKEEQDFATQGSLLGWGLRNSVGMGEDSRGGLWAVENSADDLIRERVDIHQNNPAEELNFLGHLNESTFDRYYDAPNYGYPYCFAAWDPKDLKSAIYDIGVGDQFALVINNSFTDLTCRDMFRSPRLSFQAHAAPLDIKFHPQTGHAWISFHGSWDRDVPAGYTVSLVEFEGGEPKEPRNSSTSLMNVMWNSNITGCPQEPVGIAFDSVGRAWVASDSTGEIYIITPPGSSLSGLPSPNGTSSRGSKSGRRSSAAAPLAHSGVSLVQIAVGVVVVCILLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3N7</accession>
    <name>A0A2T7A3N7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1061861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3N7"/>
    <dbReference type="STRING" id="42251.A0A2T7A3N7"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="192"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="523"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="752" mass="82841" checksum="9294533F66A0B831" modified="2018-07-18" version="1">MEAEITAVLPSIDPTITDYSVGFLTHASTSTSPEADIEFAEAISAVTSILLDAAPPSVSEASVTALIDKLVAQLNAAHGENKKAFSGRAKKLDQTIHMASQKNISSTMGLVGGGVDIDAVGTRKVESKVDKKKLEKAERKIKAKQDKKVMKNVTYEASKLITTDEQQSYDDFYMAVNPLQLGQSSQGKSKDIKIDNVDVQIGGKRILSDTTLTLAYGRRYGLVGQNGIGKSTLLRALSRREVAVPTHITILHVEQEIMGDDTPALQAVLDADVWRKHLLAEQDRITKELKVLESKPDPITVTASQGFPNQERDELDSLLSEVHSKLAEIESDKAEPRAASILAGLGFSAERQQDPTRTFSGGWRMRLALARALFCKPDLLLLDEPSNMLDVPSITFLSEYLQDYPSTILVVSHDRAFLNEVATDIIHQHSERLDYYKGGNFDSFYATKEERRKTAKREYENQMAYRKHLQIFIDKFRYNAAKSSEAQSRIKKLEKLPVLEAPEDEYSVVFKFPDVEKLSPPIIQMQNVSFSYTPGKPIVEKVDLDVQLDSRIGIVGPNGAGKTTVLKLLIGQLAPSSGLRKRPNDVSSITQNPRLRIGFFAQHHVDALDLNSSAVAFCAKMFPGRTDEEYRRHLGAFGITGTTGLQKMALLSGGQKSRVAFACLSLTNPHILVLDEPSNHLDVEAMDALSDALRNFRGGVLMVSHDVTMLGNVCTHLWVCDSGSVESFPGDIKAYKKRIIEQANAAGVVKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4K9</accession>
    <name>A0A2T7A4K9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1074263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4K9"/>
    <dbReference type="STRING" id="42251.A0A2T7A4K9"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="21549" checksum="B01617699EF05D10" modified="2018-07-18" version="1">MAAATKSLKCVVTGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPISLGLWDTAGQEDYDRLRPLSYPQTDVFLVCFSIVSPPSFDNVLSKWYPEISHHAPNIPIILVGTKLDLRDDPKTVQGLREKRMGPISYPQGIQRAKEINAVRYLECSALTQKGLKNVFDEAIRAVLMPTAKAGKKKPCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4T8</accession>
    <name>A0A2T7A4T8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_966650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4T8"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="503" mass="58704" checksum="A7A960BF1CBFE6D9" modified="2018-07-18" version="1" fragment="single">PLQEFFTQFNFQRYTYDPHKPAFEEFQRLCQVRQWGASKIGEHEPAFLLAIEREQDIRRSLAGPNAPLQEFFNQFNFQGYTYDPHEPALEEFKHLCQARQWGPSKIREHETAFLLAVEREKDLRGSLTAPNVRLQEFFSQFNFQGYTYDPHKPPLEEFKRLCQARQWGPSKIREHETAFLLAVGRGQDRRESLPGPNVIEFFIRYEYPLFTYNLDASPKSELQRLAGLRKWGEANLSQVTEQFNKAVALDAREKSGYAVSESTDSEDLEAHEVDLLVDWMRQQECCGYSYRGALPELKFRKLKEWELVDEGSEDFLSWTDSCEFEPLHIEFNQVVENVFNSLLDEFCKITGFSPWQVLVGLYGKRRQGVGRQEAETVLGKVFVNIFDFLDLFQEILRNPPTTNSGKLLRLLKPRATELQFPNEMMLGVYSSLTGRVFPFNVASKNGILALLLHPLKKFWKGRECVTQKFKREAGDELQAARGEGCAEVRRLILSREWDCFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A511</accession>
    <name>A0A2T7A511_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1074067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A511"/>
    <dbReference type="OrthoDB" id="5370050at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="605" mass="65489" checksum="F557FEF79F6329A7" modified="2018-07-18" version="1">MVFRHNFSFSPRQPALSRPSSRSSLASSHAGGLRNPDDGEVSPSSKGPSFMSSWGSKRSSVSSFASSFRRRRHKEAPAASSADDDEGPEGEIALSRDRAMVVPIINVGDCGEEDDQNGFSGQDDIPKGMGIGLSTSLSPFDHATIDIPFNSTHKETPQTLAGETSSGEPLTFTTLDAPFPFSQPITAPRSVRSNRRPAVPNIQIPPPPPSSYTIQRNQTSPSELGDSPLRMKKSKGVEQIGVRLLLKTLSPGSNNDEGVNDNTTLSHKNTRAKEFQSYLEEPTPVYLSSPWFPPTQRKSITFDDPAMESNPQSRRPSIKIQPSAKLETPSPIISPSSNRTSGSSALFRSYLGVPSVSHTPRPSTPSSTRSFLLEDDDSDEVEAAKEEQPTSRRGSLSPSSRRSSVNTFFCRGSRTSFSGASNRWSIGLGSIADTDIVIKDDEDLTGYPGINELKKQISWLCTNPPEHSSTPSDDEGDDEDRADSESGEEDSYHKHLTIITKMTSGPPGSRSGSVGPMTPELISSISDSSSGPVSTPPRRRNRRRTASSECIVLEALQEMYLAGAKAELELPPPMMKGLRISGEVEVRGDGPWSEVLLDLAQGSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5C4</accession>
    <name>A0A2T7A5C4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cora-like Mg2+ transporter protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1073814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5C4"/>
    <dbReference type="STRING" id="42251.A0A2T7A5C4"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU82951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="80838" checksum="3671C8BE7EBA9EAA" modified="2018-07-18" version="1">MDHLGTNSAAPLDPRSTPQPPVGPIHRLPQLPPLFPAPLQEPVDHFNGWQTIGERRDFYDERDYLDPSHNLTSEKLRTRGGDDVVIFDYSLDPERRTGESGNTAAWGSSPSSQHFGADDDMFFQVSKNELLESKQFNEIINPTKESRLMQSRGPRLGIIDFTQCYDTYDDHLLNSMAEKLGLQKEGETAFMNGYLHRIRKLPGRERFRTGVSLRAPFKELSGFPKLGSLESLKLGSSQLPKPGSSEDRFILFVSFPYFGGSTKEIPLHPENESVGLLDFKRLGVDVPDRKVVVVSEEESDDIGKILVHQARYMIFDNYTMATFRSKEDSAKDQIPLHHSQERIGAFRAMIHMIANRMDSELWALAKLQAFLCKLEDDIDQMISDAKTYEDNQGIERNPDDVPLELRHLLESISPEEEELLRKEMVYEQARQENVLNRKRKRVRDLITSLNRLSASLFAAISVAERQITVLQELYTLFLTRDQTKTKSREAGYPLRQNSSFKDIAPTLTLSENPEQLWPGDLVAIDRVVRGRKSFVKKIKVLVENMGARRETLFGFLRSEQAQEASSESTVKCIQDSITNIQDAYKQQDQQTKAFSVFTVITTAFLPLSFCTSYFGMNNIKEFNSNSFSLDQFWRITGSISAVITLLAVIMIWGSAVAAKFKQDSRVNLRKKIDDIENQQRQKPKRRKWSGWGSWEVDKTPHHQTLSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Q0</accession>
    <name>A0A2T7A5Q0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_965722</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Q0"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Q0"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU83038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="306" mass="34768" checksum="36810FFD9C83A881" modified="2018-07-18" version="1">MSLTTCRFYEEKYPELDSYVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKEKGYIDLSKRRVSAEDVIKCEERFNKSKMVHSILRHVAEKTKEPIEHLYENIGWPLMKKYGHAVDAFKFSITNPDVWEGIEFPSEVVKTELQTYISKRLTPQPTKVRADVEVTCFGYEGIDAVKEALRKAEAKNTVDTPVKVKLVSPPLYVLTSQCLDKNTGIQVLEEAITEIQKSISAAGGSCVVKMAPKAVTENDDAELQALMDKKERENQEVSGDEDESISDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6F1</accession>
    <name>A0A2T7A6F1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6F1"/>
    <dbReference type="STRING" id="42251.A0A2T7A6F1"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="152" mass="17062" checksum="67FF88CB715A18AB" modified="2018-07-18" version="1">MTSKVQGNILTRIYYTWKSLKLPWRRKVFVGMDLEGNSFWELPISAHGRVRRIVAYKDPKRDLVDYKLPPQWTQWLRHNRTAPTIAELHADIARQAQLKQLVAAADARWNSKPSLLGAAPRPPVDSALESNVKPCDDSADGKKCAEGAGSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Z4</accession>
    <name>A0A2T7A6Z4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1105123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Z4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="21418" checksum="9E864F28CB6BB6C4" modified="2018-07-18" version="1">MTIISSMPKSESLYLCLGGGGDDLDPNCCLLFRFDEHICKFPHGQAARPQPFRSTMRPHRPLGVPNWDSRCHRSLVRPPAFSLDQISYGPPFTRIKPGDYRSRLTSAIELILKASSKSLSSGTSKLVEAMALTLGKTVTKNYTNPSKLFPEPSAHFDSSFYLMPAFVPAVRGFGASGVSFLLSEVDEFVCVARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A855</accession>
    <name>A0A2T7A855_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1189323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A855"/>
    <dbReference type="OrthoDB" id="10414357at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="52" mass="5875" checksum="6286501BDECF60B0" modified="2018-07-18" version="1">MSIFDFKCNAVNFFCCTWNITRASRRNEAPLGEAPITTQPTPQEPMNANPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8C2</accession>
    <name>A0A2T7A8C2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8C2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="10579" checksum="8D7B4655D1E7E9A6" modified="2018-07-18" version="1">MLSNVCKSWLRPLGVSEDSPAAPQPKDEASFGGRRSSSSSLISEDSAHEDNSIGRLLAALDRGQSLQAEIAAEMEAAGGRLSGGLLVKYIDIAREICQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8G7</accession>
    <name>A0A2T7A8G7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1164095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8G7"/>
    <dbReference type="STRING" id="42251.A0A2T7A8G7"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="66" mass="7367" checksum="EAD26895C976CACB" modified="2018-07-18" version="1">MTSFKDNCIVGIQANGDRIEKLLHESLMLVTCLNSKIRYHMASKVAKNAHKKDYTKAVGLGVRGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9Q2</accession>
    <name>A0A2T7A9Q2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1060305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9Q2"/>
    <dbReference type="OrthoDB" id="5396892at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="557" mass="59741" checksum="5F4DFD0775EDF8C0" modified="2018-07-18" version="1">MASYYSTTHSPRRLSERRGIPELQPLEPAGSPKALISSRVSLDNELCRPVSQGSSVISTPYSSYETGNNTAMTTPITPTDISPFKPQVSDIMSPITAPPSIREEDEEDDELCDCNCGGGSVDGLGGLGLEALVDGASGRTTTRSLLERQHVTTGGNPSFDHDYLVHQFQNSHINGEQYSMPPTPPSHAGEQDFDFSTVDSPILRPRRSGELVIDPECFSSGPPSLPQSPSSEGGSGRSRAATILNKIVPKIRTSLKRRMSSPNNTPQVPSIPSAFTMPTSSAYYSPRTPPEDHLESFFRELRGPSEKPAAGDDGMSIHSAAEAEAPLPPPLHPAATFAGETDIISPLQSPRFLNTPNFSGTDVFPEMCNSPIPSELICSPLHPPTISPLMSPSLASTSQTSLSMPAPSMTHKKVPSIDPATPLAPKKLASPVTFVTANSLADMIEEMNRDLEAYDATRARMIESGWSSAQEIRNVELQKEDKEKNWKHRIAESKKILEAARRSEVKHSAMSSVSSIDSLGGSYVALTSNPISPIIPVTILPGGDGHSVKGSERALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9T0</accession>
    <name>A0A2T7A9T0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9T0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="70" mass="7832" checksum="320A91E60062FD65" modified="2018-07-18" version="1">MHFVWFTKLTASGILLRASPHFCPSRTLCPFKFPSEDYGRLGSADTASIGRSEVREGRAREACGKKNQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9P9</accession>
    <name>A0A2T6Z9P9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1138777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000672">
        <property type="protein sequence ID" value="PUU72199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9P9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015630000" evidence="2">
        <location>
            <begin position="20"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="224" mass="23501" checksum="C57DF643ABC9EDFB" modified="2018-07-18" version="1">MWTYLLPTLLLLQIIAVQAHPRIFPGVKLGSVLLQGYDKDGCPTEPNFSATIPSTLSGCTPITSTGITNVVVVANDKLPSTCKLFLFENDNCGGTESANIGPIFPSSIPSACIGPIRNPAGNVFELKIQSSGDHISENVPGSAPLADLPTAVPLTVKGDSRNSIAQSTSSQSALGLPARKENSSQPSRSESTNLDPSAMPRSTPPGAGPKHPGNQSRLQFSWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9T7</accession>
    <name>A0A2T6Z9T7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1012292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000684">
        <property type="protein sequence ID" value="PUU72184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9T7"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9T7"/>
    <dbReference type="OrthoDB" id="10299213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="72" mass="7908" checksum="E9DD5D67834B278F" modified="2018-07-18" version="1">MEILGKHHVGFNNLGVQLFADLERDLSLGLKKGSSEKVDLERAIAEQKELLQERQTLVCTPNSPIGVALVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9Y9</accession>
    <name>A0A2T6Z9Y9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1138047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000578">
        <property type="protein sequence ID" value="PUU72312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9Y9"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="19234" checksum="565367AE21060DDC" modified="2018-07-18" version="1">MEILKQPGIQEFHNRLMANASEMREVFEGTQASGSYAIYPKFRVPLSHSIESLTSYDSIVDIDSDAESSSTIECKRRQLSKHKPIPPLGLIRKCQNNPATPIVNAVERMITKPIALLKVTPTVHQAITKFRQDYKGKVGWSMEDILAGYDLLESSIKADVFLALDGREDKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA96</accession>
    <name>A0A2T6ZA96_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1197577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000540">
        <property type="protein sequence ID" value="PUU72422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA96"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="97" mass="10882" checksum="69DE4C5251CBDB77" modified="2018-07-18" version="1">MKHFLWGTAGQWSLAAGRGATLEKDRTGPLNAVHRRPPPGRTDCPVENTEEPSLGSNPFNNSLKLRLQLELLLKQLGGNKLDDSDRCVQEWQPKMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAL9</accession>
    <name>A0A2T6ZAL9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000515">
        <property type="protein sequence ID" value="PUU72525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAL9"/>
    <dbReference type="OrthoDB" id="5388920at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="226" mass="25853" checksum="AC2F24703C69E462" modified="2018-07-18" version="1">MTTIAEEDRRRERRTRRCLRGKGPSQRPYHHIPCSAALDFARTATPGQPDPVKAHRLTLPVVEQYTKDLTLEIGKPPPHASRLHNIPTMDVLGKAGEKDLSRRVTQRNVDLSRYRFTAAQLLIPPVTTGEESGAEHLRWASSHRRHSLSLQLVPTDRPDWTEQDECSKSTLTSVLCKFGPTLRKSESIWSMRSHSKHFENVTPDDSSVLNMRARRFCYPWNCVCFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAZ2</accession>
    <name>A0A2T6ZAZ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1167829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000493">
        <property type="protein sequence ID" value="PUU72639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAZ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAZ2"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="36593" checksum="29A75FF9AE49DCEB" modified="2018-07-18" version="1">MLHQSSSIFSLQYREGDPKKSVHLTAALGHKAGMTTIVRDLDRPEIVEAVTVIETPQMVVVSVVGYVETPHGLRSFTTVWAGHISDDLKRPLHKNQYKSKKKAFTKHAKKHADRGKEITHELEHIKKYCTVLRVLAHSQIRKTPPKQKKTHLIEIQVNGGSIANKVEFASENFENVNIHVIVVTKGRGFNAAEEDPQGFEKGSCIGAWHPSHVQRVYRVGKVDKEDNASTDFNITKKTITPLGGFPRYGEIKNDFVMFKGSIPSVKKRVVTLRKSMFIHTSRKSVEKVELKWVDTSSKFGHGQYQTKEEKHQFLGTLKKDIVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBC3</accession>
    <name>A0A2T6ZBC3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1008098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000464">
        <property type="protein sequence ID" value="PUU72798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBC3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBC3"/>
    <dbReference type="OrthoDB" id="5323643at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015636703" description="Beta/gamma crystallin 'Greek key' domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19552" checksum="8D813CD78730747C" modified="2018-07-18" version="1">MQAKVFLLSILSIILAVGVIATPVDVIPTLVDGERTPPPTDVNTLLDNGRGREAFFVGPPDPRPTGPIITPKEGDIPTPSRVVARDLENLEKRTPGCISATTNPNFTGASGRSCNIPNGHCANLTPFWRSNISSFRPDPYTYCEIFTGPNCSGLFFGVFTYPGFGLLGVFDNNMGSIKCWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBP0</accession>
    <name>A0A2T6ZBP0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1136443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000447">
        <property type="protein sequence ID" value="PUU72889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBP0"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="27277" checksum="19778BF12B523E34" modified="2018-07-18" version="1">MSFFKFPTRLTTAVRTHTVRRPTYRIRTTINRCLWPAINHAQRNASLMCHEAIEDQLKRIQEQQDTPLKHFQELEQQCQERVEQKNIQNRELLCAALEERTKRMKLEGRYNARGALERIVYQAKLEKKISPTAGISEGLRELAEGREFTDILELEVKARKLYDWQVMEAFDNLYRESKYSANGNDDAIIIVSETSWMDNHRAALVCLLKLQSSWPCPLAWKEELHEFPKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBT4</accession>
    <name>A0A2T6ZBT4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_607254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000440">
        <property type="protein sequence ID" value="PUU72943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBT4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="525" mass="57920" checksum="04FF168A14D4184D" modified="2018-07-18" version="1">MENMLIRDVVPAVSEPALQGPVSHVAEVVEQTLPVSCPTAAQSIPAPQVIPSDDDEGIRRKVVGEMETLLRGGSIFQQPQLATVPPAILAQQTIAQPAQVSVQPTSSETLADDEKIKQKITAEMEESLQKVRSQEGASDQSGAQQAALHTESEKRVDEKREAEVETEAERHQPAPERAEREGITKLAEAEEKTLEAEARKVAELGARRFAEEEELAEKARLELEAEKAAEAKRLLLAEEAAQKEKAAELERLAEAERQCLDAQRHEEESAAAKALEERRAIEAERAAVVEAARQVFVREQAGFDDKKFQEFDRQRRLAEDERVRLADVALAEREKAREAKQQREREIEEERVKAETSVFSSPTGLGETVEEGVLPIELSEKVAKREISRDPTRATSASKNRSVAPRSSTPTLGKAFAKDQKQRFTLGSSSSAPNTTAGYKVRIVSGFGSISADCFDSGQRAGRRPGLLIDKVIALQAGRKNSARRVKRRILRQRDPPPEQARRPLVGLVTMGRTLQLRLGHLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCK7</accession>
    <name>A0A2T6ZCK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000398">
        <property type="protein sequence ID" value="PUU73231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCK7"/>
    <dbReference type="OrthoDB" id="5479481at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="16755" checksum="4871FF6147E04F0D" modified="2018-07-18" version="1">MLSQFDRRNNSGNQEYNSNGMSLGEVLAIIIAALTLLVAAIPLFKCVRFRRWLSSSISPFFKKYLGVALPSFMSTVVTTEDSSAIPAPEIPMPGPAFIYNDYSNSHFTGNCSNTFLYNQDGITGEDGRVLQVEESLEVRRLERVATYPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCN1</accession>
    <name>A0A2T6ZCN1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1069147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000396">
        <property type="protein sequence ID" value="PUU73252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCN1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCN1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="436" mass="49463" checksum="6F2168472C79C557" modified="2018-07-18" version="1">MVGKGEKSGKRGGPGNLGARVVKKGSEKGGKLLLVDRKYRVVGGGEAVLGGCEGDWKVYKGLKHVAGGWENDKVRLEDKMVLDGSEWEMSGKGDWDIWEDGMEGVEEEGENSMEAVEEIIKKMREREDGVEIKKEKIEKLEVEKERKGEGSEGGEKNKRVEEDECCEGKKKCKEKEVEEVVIEESGVEGMGAMEKWALEKKAKERREKEERKRREKEGIINRGKDRGMGRDSVLEMWKEWQDYEELVKDARYILGVKMEEARSFMLDREIRKVLELSLGGELGGKDIRGMKRDEIEVKSEVVVENGLREKEDLKREVAVEGGRSYSEVLRGSPEGEEEIEELAEKKDIEVKKWLDDSLERERRSGKVVEVVMDSQSGKSEEDWKVDELMEKLGVSKNAVDKMKVCGNRVKMVMKDREVAEKIEELGKEVIGEAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCZ6</accession>
    <name>A0A2T6ZCZ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecQ-mediated genome instability protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1095213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000385">
        <property type="protein sequence ID" value="PUU73362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCZ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCZ6"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790:SF15">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="RECQ-MEDIATED GENOME INSTABILITY PROTEIN 1 RMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="4">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="3">
        <location>
            <begin position="71"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="239" mass="25921" checksum="1204E9EDE0402A74" modified="2018-07-18" version="1">MPLPPIDTILRNFSTNYSLHIRPTYLQTLLSSLSSQRQIPTGPALFGWLKFRILSSDITESLQPHANLCFPVNITDGDVQSTVLPGPVAVQVTGIEDMGTSKINQIDRIEMNERGEIMKGKEVIRLVPEEEGSDGGEGGFSGRPPVVAAKTGPHKLLMEDAGGRGVYGIELHDVQGIQVDMPMGTKMVLKNVTVARGVLLLTPANTLVLGGKVEALNQQYLANRKQVLNSALEKLRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDK4</accession>
    <name>A0A2T6ZDK4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1134958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000367">
        <property type="protein sequence ID" value="PUU73577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDK4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDK4"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="34112" checksum="E8F3B7AF09144CA9" modified="2018-07-18" version="1">MLSTKLVKFRRVPINYRTQLLASGMYFKRANHTKSEVSHDDIHNDIPNYQGHEEPFHAEKKLGQHEPEKSATDMSSDVSQLKINAAVVNCHLESIKSTLHDLKERIGVDHVDHGDNNPPWWIRSVQDLPEQLKAMGNRFEKTTDDLSNKIDNKIQHLDNKIGHLADKTNRKSDKMGRCKTVQLSGAVNCLELFADHAQRWLTLSVTHNFNRGRKIQFIVICFLYIVCRHEKSAYMLIDFTGILNASIQLEFDWLLSANSAPDPTVYVYRPAKHLHFASELTKITNDALCIVQRMSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE43</accession>
    <name>A0A2T6ZE43_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1094488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000350">
        <property type="protein sequence ID" value="PUU73716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE43"/>
    <dbReference type="OrthoDB" id="5353310at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="83" mass="9253" checksum="E82E8E46BBA0F99E" modified="2018-07-18" version="1">MTHPDPTFYQRFYHAARIAGPPPDPEKPKKQNSETSISLDEEGTWLAREKQKRRRSYLLCGVAFLTVLIVGIGIGALVTVIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZES0</accession>
    <name>A0A2T6ZES0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000328">
        <property type="protein sequence ID" value="PUU73998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZES0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="136" mass="15487" checksum="A3FF9CDA71456088" modified="2018-07-18" version="1">MSVDADSNKQDMKPKGNESGPQEYAGGSDTTCSHEGPGQSRQPPSTKHDDDYGFPPWDALDINLGKFVELYSLTINRGEGDIIWQMEMWLKCHFKMIKCCKKVTIPNSMFMHRSKRALHLSKNMLVAITRNTRDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG34</accession>
    <name>A0A2T6ZG34_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_452230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000301">
        <property type="protein sequence ID" value="PUU74416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG34"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="22075" checksum="0D1BFE5DD66145C5" modified="2018-07-18" version="1">MPGHPHEGVPEGSIPTEISSFSSEGKRIIIPQAPSSSFDSLEALPSALADTSPPPLACPVSGCLLVLKGEMPHRYLRHLKYPGLHGRTGDEKETWLNLQKMEHERLLAVLGSTPSRNTSPKEVPEVGQGSYADIIKLVEDDKAEEERESRAAEFELRAKNMGITEMKFVAQKVAIWEGMWAAKQNGDDIGVGTLYSAPFGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG99</accession>
    <name>A0A2T6ZG99_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1000414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG99"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG99"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9934" checksum="520513687C6B6847" modified="2018-07-18" version="1">MALHSAGAVREKKQTMAELKLRRLTELNARLREDLERPRVKVSEACHSMIAYISNTKDFMVPSTWGQVDKREDPYAPIANGPSCCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGZ1</accession>
    <name>A0A2T6ZGZ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_924715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGZ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGZ1"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="12801" checksum="20EF48BD9B7ADBCC" modified="2018-07-18" version="1" fragment="single">SSTPLHFAAISSNQEIVALLLSSGANPNAQDLNKKTPLHRACEVKASAAVVSTLIGAGANVNARDIWGETPLHLSADFRHEAIARTLLASGADVSSSDMCGRTALSYAVSDRSLQILEFLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH01</accession>
    <name>A0A2T6ZH01_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_923454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH01"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH01"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="12817" checksum="20D275A2846DFCFC" modified="2018-07-18" version="1" fragment="single">SSTPLHFAAISSNQEIVALLLSSGANPNAQDLNKKTPLHRACEVKASAAVVSMLIGAGANVNARDVWGETPLHLSADFRHEAIARTLLASGADVSSSDMCGRTALSYAVSDRSLQILEFLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHL9</accession>
    <name>A0A2T6ZHL9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoside phosphatase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_378396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000257">
        <property type="protein sequence ID" value="PUU74985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHL9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHL9"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="181"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="685" mass="75099" checksum="2D1131634A5AAFCB" modified="2018-07-18" version="1">MPEKYGVILDAGSSGTRIHIYNWEDPVKTQKKGRKGELQKLPEIKTNKKWTKKINPGISTFGEHPERVGEDHLKGLFKHALSQIPKAAVADTPLFLLATAGMRLLPDLQRKTLLEEICAYARRTTQFLLPDCGLHIQVIAGETEGLYGWISANYLLGGFDDPEAHAHGKGHHTYGFLDMGGASAQIAFAPNATEAEKHADDLVLLKMRNLSGDPVDYKVFVTTWLGFGVNQARSRYIDALVEASSDGGITELPDPCLPKGLKSTLKGKKIDGDVPDEKAHLIGTGKFEECLRQTYPLLGKDDLPCKEVSCLLKEGHAPAIDFDINHFVGVSEYWHTTHEIFETEHDAKAYDFATYQQRVNEFCSQDWGIIEELVEKKKWGNKVDEEKAMQTCFKASWLINVLHNGIGIPRVGLETSGNSNHNGTEEVIEAAKSKGFLDPFQPVNKIADVEVSWTLGKMVLYAASQIPPDNGEVNAVGFGKNVIGDNGLPDNFEYAASQRASHHPDGSGMSGGSGGSNSSMEGGNDQAHWHDSLWREGDKTPRRIPGLLLFLIIFCLAGFLLMGRERRGKFWRAIKVSSKRGKRKVLGSHGVIMYERVMEEGRDQFADFELGSVSSSSSSDDETGGWRAKGALYDPPTGGTGVDAVRSGLGTRVGSRERLPMTTRSGDISPRGGSSARARSPMPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHV0</accession>
    <name>A0A2T6ZHV0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Telomere stability and silencing-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_373223</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHV0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHV0"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="88"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="206"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="32424" checksum="91142F8FB6D0D7BC" modified="2018-07-18" version="1">MDSEPEMPLINAIITTFPGLPTYNLPLPASTTISSVLPRLRLLLPPTLLHSRLLLTPTSSHYHPPSAPLSALTTSSFLTLRLHPPLCGGKGGFGSQLRAAGGRMSSRKKRGQQENNDSCRNLDGRRMRTVKEAKALAAYLEIRPEMGRKEREARKERWRKVVEEAERGGRNGSASTARFDDLEWLESTEEERVRTREAVERVMKELEMGGLDGEEEGEGGSSGSGSDVEAHGGGDGDIGEGSSTAAPAKKGVKEMKFSGWDDEDDEFLSSDEEMSDIAEEDEEEGPVEEESKGKQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHV4</accession>
    <name>A0A2T6ZHV4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nucleoporin protein Ndc1-Nup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_996438</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000254">
        <property type="protein sequence ID" value="PUU75036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHV4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHV4"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU75036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="31587" checksum="1F525A5B6DD4B0A5" modified="2018-07-18" version="1">MLAFWELAYLAQNSSVRRKAIYLDVNRKPAKIFEQILNQSLSILGEIDLKLAEVGKPPAPTAVILAAPSSTAVSTIPSPPPIPMSQISPLLTSPASSTRKFLEGVQSKDGSTPTLQHVIQKLPYQPPSIAEVEATATKSFKTRMEPFLSSPWGAMFRQSIHATTSQLIPNVGLQVNAVQGISRLVISALTEDEYGTVQKHVPTLLTSFVSTMDALEKYLASPPISWTDVESIQKQEKGELHLVEPRLLLSTLKEGFKDIATAYAPHVDSMEIPPDTKKLVLEARERGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJI9</accession>
    <name>A0A2T6ZJI9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine phosphatase superfamily</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000222">
        <property type="protein sequence ID" value="PUU75616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJI9"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22570" checksum="8AFF729C7EB68F01" modified="2018-07-18" version="1">MPPRIITLVRHGQAEHNVSRDFQVRGTSLTALGETQCQELSKTTLLGFKKRVESGVKVKFLAELQETSDMPSDTGSSRDVLEKEELFQGLDFSGLPDDWTSKKGKWAPDPDSLRERARIVRKWLKSRSEDHVVAVSHGYKLGIATATSRALAGAKPSSGSYAFVEGDDDNASIIETDESKERRKEGKKPVGETEMKPLGEVVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK30</accession>
    <name>A0A2T6ZK30_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1102690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK30"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK30"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="246"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="495"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="623"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="518"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU75847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="726" mass="81309" checksum="49593536C61225E7" modified="2018-07-18" version="1">MEISGDEPLRTERERNGNGKQVEQVEQVEQVEEEKKPVASQEDVIQNVLSIFPDACLTHIAKLYREYYLLHGSDITEFIANKLAETDYPKSELFLKTGMKRKRVEEDEKGEKSLDYEANDRPPVVGERYELVRSILKQEFPLMPVRYIEKVMTQNRNYLAKSYSALVKADKSYNPQTNAPYKQLMHPRKVEGQSHELKKGKDWTEISAELEYARGEVRREEMQAQMDADARLAAQINEKEHQESNMLMECGCCFGEYPFNSMTHCNDLHFFCLDCARRNAETEVGNGRHKLSCMDGSGCKALFPRARSLAKIEQQDALRIAEIDGLVKCPFCDYGAICGPAEVDKEFKCQNPDCMEISCRLCNQKSHIPLTCKEYAKNNKLNVRHRVEEAMTEALVRKCNKCSYPYIKEYGCNKIHCNRCNTLQCYICSQTIKNYDHFNDPARGGKIGNCPLFDNTEERHHDEVETAAKKTMEMLRGEHPDLDDEDLKIELSERVRKEEEAKRSRAAVANGGIPPYQPQAARQPAVAPPVVRRRAAGPPPPAPPPPAPQIGGPVMVAGPGPRGRIFQRVRDRIQQVVQPQAPPAQPAHAIVGHHPLPLFHQVAQNMYPIPIPQFAPYPAQNQYPGAKPAQQPLVGGLPAAHGAPVVNEHIPPPPPQPPPQSHRRAVLSRRNTVAAARPMGADMQGMGMGMGMQGPNLMMAMGRAQAQAPAPPAAPPSGVSAPRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK48</accession>
    <name>A0A2T6ZK48_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1102694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK48"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK48"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000052">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="8303" checksum="520A13538CC69C74" modified="2018-07-18" version="1">MIEVICNDRLGKKVRVKCDPDDTIGDFKKLVAAQIGTSAEKIVLKKWYNTFKDHITLADYEISNGASLEMYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKD4</accession>
    <name>A0A2T6ZKD4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1102622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKD4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKD4"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9784" checksum="3020C4A17989CDE4" modified="2018-07-18" version="1">MENDKGELVDLYVPRKCNATNRIIKAKDHASVQISVGKVDESGRYTGENITYALSGFVRSMGESDDSLNRLAQKDGLLKNVWSASRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKN0</accession>
    <name>A0A2T6ZKN0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000205">
        <property type="protein sequence ID" value="PUU76048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKN0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKN0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="197" mass="22246" checksum="37DA6AA6118317ED" modified="2018-07-18" version="1">MSSPARVHRYSKNPRWHSSRGQQTTLFASSENSVKPAVTHEEYVYSIRSQKVASMYSNPGRALAEIKVIRSIARRLEAMVDFTQYLPGIVLSGQDGEPVFAVYCGISWYWVSGRCSVGIRFYSDVVDKVLTYWRDKELGSSPFVPLTDEAPLARFGLDEWDTDGEGEVEDDMDEAPKIWRDMKAKKSGSGGGESFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKP5</accession>
    <name>A0A2T6ZKP5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKP5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015600219" evidence="1">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="17984" checksum="E3F216556E36D84A" modified="2018-07-18" version="1">MSIISLFALLLFFILPSTTVGHKTATVTVIEPTTTVSFTKFLLPTNHYQSIPRTGPLHTCFQKISTRKSIRKNWFAVAWESGKTLDSLKCDQLQKSIRKNAGKGLSRWRCYWYFDPRTRTGVSKAQGVIKSKVGKMENIIEKAVGGIWGVQGVERCRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKP6</accession>
    <name>A0A2T6ZKP6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1089034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000204">
        <property type="protein sequence ID" value="PUU76067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKP6"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="20391" checksum="028539DFA5638D55" modified="2018-07-18" version="1">MALVASPDGLAAAAPSTTLFHCQSDPPAKDGVYTTHPTGGYFTHTPNHSQYPVRPKQQPASGLQEEEPYPDLNAGSLVSSLPPPLHQHMHHRGEGGAVADHPNPNPNVCSCGAAFGRRTDLERHQKTTKKHNGDQHGPACPVKGCRFTSKFTRDDNFRTHCKRKHGMSVDVVNTYIRWWRNRKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKW0</accession>
    <name>A0A2T6ZKW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000205">
        <property type="protein sequence ID" value="PUU76054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKW0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="22466" checksum="D3621129AA0ECBBD" modified="2018-07-18" version="1">MHSKVALKAAFRPTTIPIFPTSSYTLSPHLLHRPTPFPTSLALFTTPRPHFLVRLVHFPTFPNGFSHKRTSNLKEEKGNWEGESGKGPQGKKGAPISEVALSTDEVLTILENYPLTNRPGYRKIFIDIKMELRIMESIDAQSVLYSLQSRAQQSELENQLRTMEARAEAKITSGLERLRFEIGNGCLQHAEEPNKITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL13</accession>
    <name>A0A2T6ZL13_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1130118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL13"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL13"/>
    <dbReference type="OrthoDB" id="5421656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="929"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="268"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="577"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="754"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="901"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1087"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1161"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1210" mass="134790" checksum="C50AFED77AC60DB8" modified="2018-07-18" version="1">MDPHQPPILPPPIDSESNSSRGNFFPRRPAAGAFDSIGQNFKFAPPARKEVPSSCSPNTSERDGIRGKSACVLVCEATNSLAAKSNAPFIPFSLGPLNRKRPIETKDSGFPPHKASRPTKRERHTVTSDSSSAKPTVIVLDDDDDEAEDQSSAPIPASENGPPGKVRATDIHYGAAQRDKIPRSREDGPCAKKRPSGLPSASSDSSAQSSQASGRTVLSHNRNLRRHQGHHPVSVVGKDKPDPSTPTPSKFSDALDWNRSQRDLLIAMNSLSAEKDSIEKELISKELALKAEHCLLEAEREKAAQLEDKIAKNDKKISIIKEKTDGLQKFFNGMGCDYKVLQEKYAKLNALFNEVRKERGNIQNDHEEIRLVVQKLQKDNGELLESISHTKEKLFKFEKLNETNVYLQEQLSENAGLLAAERDRVQSLELQAREDINYFRHEIEQKQILFDITQKSLTDFEKQISGVDNLGRAIETVKESNSKIAEQLIQKFSTKCVQLETNLSIRVHDIKGVIEDAVNKGLENSEERLNGLASIFEKTDMRSDYLKMVNEYTSIVKISTQTHKVASDSAGSGSGFVEHLNSQIYHLESQLEEMREHRSLGLAKLSQKEAELNALKHELAEKQNEGLLCNRLESLLQTGNAVLGEKIASLGLNIQNGPGDGSLIAAFNLEVSQLNGSLEQITRSFNDHLSEKNREINRLESQAKSLDALYSEACEKIASFDKEKTEYISLIGHQRLQERIDLENTANSLRLSETSGLNNRIKSLEVQKERLETANALLEERLLARASDLSRNEEAQTVAADVEKATSETLNKCNNLEQELRELRFQSSMERALADRKCQQRTTESEQLQQQVEDLRINLIASNQELIDTQAEKKVLRQGLRDAMQTLETSQDTLKILILIAIQGRSEKESLAARLRNLEDENQRLLEKGVEVFPASKPSRRSSDTLSQSQPPYKSGSTKKSGKVKFSESPIMSLTSIGDASQFRRAQPNDEEVDFQGLAAEILHTSERERVYWKATNTEPLIKPIAPRSKPREPRIEFGDSGKRCNQALKTLSSSTRKAPVTKAKVTEDSQNSDEERYLALPPMSSPPMNFTPANINNGGPSGFNPGESGWSALNTQLQSSQFPQVAEKTKVSSGHRSEALGHEAGRQAKPKLARHRNKKARDEDAMVEEPTKEQESGEKGTGVHSSGSFRAVQKKKRTSKKHQNENFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLD6</accession>
    <name>A0A2T6ZLD6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_262085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLD6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLD6"/>
    <dbReference type="OrthoDB" id="5384455at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="20425" checksum="6DF07630561ACACB" modified="2018-07-18" version="1">MPPPETIYEEFEFANDMRETQASQFYRPYYVLLNHIFPPEEGYMVYPQYEPPMPSMSVDFRNIFTVRHKSYSVFFLQVKSSEDLSNISSRQEADLQMQEKFRHIIGAVRIGTLFGACAMGTKICIYMLHMGSRQLFRGPELVTEAALADRWNTDILTPEGQGRLCKIVQHIKEKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLI2</accession>
    <name>A0A2T6ZLI2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1109548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000192">
        <property type="protein sequence ID" value="PUU76316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLI2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLI2"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="306" mass="34363" checksum="F072FFCE9270891B" modified="2018-07-18" version="1">MTIRSVLASYSWSCPTNGTVIRVCYQDSAGNIRQTIYDEKLGWYTDPCGIIASRDLNYGLATTGWASGDEERVYFIGVDNKIAERRFSRSKNGWYDGELTGKFTAAHYSQLAAISYEANGTWCIRVYYQDKDNMIHELCRNGEEAWFEGYIFPASAIQGSSIACSHIIGGTCSYFLYYQKLDSTFVEYISHNSTKWRVGDFYSQLLYDPGAYITCSSYSKEGKNHHRVFTIDRDNKLCVTKFDGSSWAQTSQLTDALPRTTAAATAITDHIPKVRVYLQIAGGQIAEWGTNDGTTYSLMKNPLPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLS5</accession>
    <name>A0A2T6ZLS5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLS5"/>
    <dbReference type="OrthoDB" id="5388996at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="643" mass="70310" checksum="4D057A2B7E36D58F" modified="2018-07-18" version="1">MVRTVNTNSVNPSPPENSNNGWTTIPVKPNKPKPLVSFPKYPTEPTLHMLVLKSYFVNSTNKWIWHCYLDDEILTSNPRGRERHLRIQKAFTKSGTFFAERGIVLHSLNVSTPRMVELFFGSEEDLWKADALVQEYSQAMTGVDDRIRRMENTGKMVCHGVGFLEQFAGEFVGRWNLKEERLRELEDMNPVFYSTGKRWLYRIRYVHYMSSQSSSDHLWRNGSTWAVTFNDFRVAECFIDGYAEFNFFNDPCSGGLSWYQEGPFRSIPNPGSFERNSVPWNGGESVPGTAESSGVTAASTSSGGDKLIKKRLEHLVFGENPEEAASTLNLKVSITKPKKPSNPILTNAYEKGQNPTDLKVTSTGQHQESKIQSPPTATIAPVKYAPEQAVTKIDTTERQKPQSLGHLVKVTTTPANPAAINMNRYRKAKPKNQPPPGDDEGQFPPLPPPLSALLPQPLPPPTLPVGEPTATKITSGTLPDTVNKVSPPESSTLPTENVRPQPTERVKYQYAINAKRPAAKVSLPAKKSTPSGSAGGSSNSAPAAPASALTGQSTTTATATIAPGVGITTATTTTTTGNKDTPAQEALDKPRLRNVAARRRRNKRERKNAGKNAAVTTPATRATTDASTDTNKGGGADNNRQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMF4</accession>
    <name>A0A2T6ZMF4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV radiation resistance protein and autophagy-related subunit 14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1102237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000180">
        <property type="protein sequence ID" value="PUU76667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMF4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMF4"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040939">
        <property type="entry name" value="Vps38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17649">
        <property type="entry name" value="VPS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="63207" checksum="32DC650B947B3243" modified="2018-07-18" version="1">MPSDSDGLRTTPDTDFVPGIGTAPRERPLLLPSGRKLRHLNGIALRNLTTCVQKAQSARPAKSSDDDVLAGAWKSAGKLPARTEELTSGSSSSGGGLIHAKSEMDLTRPGGQLRRRSTRGNPLGLENPMTRQKRLEDVTAGRMADVFFSLHTVGGGALIERSDDPIYISEIVSKSMNPNFQFFELSHSAPHVSRLDKVTVKIWAGTQGQFRLIVELNVALSALQFIGKNLENFGYPFPTNSIIFFLSDGIYTTFMDISLSSPALHRELPIRGTKLTPTSIQSTTSYDAIMKLNNLEDCIKDAEQTSAKVSSQINAILERESSSMTPLREVSQARESRKTLQGFLASERKRLSAAVKKREALQQSLRMRREAMAAGREAQKTGENYLKEAAVGLERCRKDLGETKKGIEAQRRRIVEDLQTVYPVEPVPNHPLAFTIRSLPLPNTHHEDADPDTVSAALGYVAHVAYLLSFYLGTYLRYPLQPLSSSSFVRDPISVIAGARTFPLWVKGSVYFRFEYAIFLLNKDLEQLMSSQGLWVMDIRHTLPNLKYLLLFAGANKTLITLHKSTFSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMF9</accession>
    <name>A0A2T6ZMF9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMF9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="21572" checksum="DD0437EDC1887697" modified="2018-07-18" version="1">MGGTPLNEVNENLLLFPHSNVDKLKIATTGVVFLLDSNDGPREIACVDHPDDHAMSKSKGNQSEPRVSMGKGTPRGVHQESKCCLSTLLKNSQPSTLLMSSGWAVGYFRRNTQQQGFWHRYRHRNPLLMQDVSIVDFVEDILDRLIYYFRVVGSHRSLKNACTSTMQVNSNLEIFGLSKVILIEPESEVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNB3</accession>
    <name>A0A2T6ZNB3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_201339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNB3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNB3"/>
    <dbReference type="OrthoDB" id="5396937at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="59544" checksum="86809B9A20769AC6" modified="2018-07-18" version="1">MSIVSIESSIGRAKKLVRSKIRSMMEECKVRKFAMELHSELSGYTTRKSGYCEILRMARRTISFLRPGQRAAAPIRDGTKGSRSLGDLFFGLPVELQLEVVNKLFFFDLLSLRRTSRKFRELTMQNENYIVRHHIGQWVPLHITKLYPPPTDTPPTLGYLTDLAYKQRVSTHLALSLARQIVKEMMGGRQSRRMSKEATVYVLNQLRLGMAPLIFALFHFFETYRTRRLERLWEDNDHDSSPVELDPLPLADKMRLQGDIISQYPDNLLLQVHQMYHLLLHLFMRRMSSPSFSVQRTLGCWTRQRPPNQAFAKVLILGGIKEVWHIYRIKGYSRRRKALDKYLRKLDMEQACPPKCKSGSKARAATTPQQSRGSSIPLNLDIAALSRPDYDHPPTPPLSKLARLDVDDLTQLWTPAAEQRLIFGGIVGSLEEVRCCGQFVSQLLGGVTESDDEEDDADGDDSEDDSDDSADDEVSPVLAPGGGNTHYSNTFLSTDSSWDDELAEEEDSGLFFDDEGLGLGSVLASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPX6</accession>
    <name>A0A2T6ZPX6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_986481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000149">
        <property type="protein sequence ID" value="PUU77550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPX6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="206" mass="21506" checksum="EA6C8010F0549DDE" modified="2018-07-18" version="1">MEGCGIDAAFRVIGAGAIVAASEGLEAGGTVELTWERGAIGIAGLEVVEGGEMDAAFSIVRTRTIVAACEVSGAGGTVGLIGERRVARYSVKVSERPAGGLSMARSSSIRRWASSVRSRDIQGRLLIASRMYLICSVSESMEGPEHDRAIKGLLVELASSSSSSQSHGGSLTLWDCIEGPGVPIYPSGSVIEFLSEVNFRHGNLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQD9</accession>
    <name>A0A2T6ZQD9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1193869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000145">
        <property type="protein sequence ID" value="PUU77687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQD9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQD9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="569" mass="64708" checksum="1A71C3FEFE4877DE" modified="2018-07-18" version="1">MLTPLFLTTALLFMGYTCYSLHTLLCKVRPLGIPYFVVPFYPGPLTRIFPIPFVNLLIKVFGLTHPRFFLMTSDWQVRRRCEVYRFIRSDIFFTVTPWKVILHVADPDMAVEVLAGKGGNGELYTRPDVYNSMLGLFGENVITAEGAVWRDHRKITAPVIGKSLSVVWEESLTQIQQMIRYYDKHEAINTSYRDFRRATLGVIAHAGFSKVMEWCPLTTAIANEKDGEGSYQKCLHVLFENFMWAVIAPSWILEMLPFKALREAGGAANNFRFFMNEWFEERKTKIELDNKTTLGPSSKADLMESLVRSSGLDKGSTLETPLLSKSEVIGNAFIFILAGHETTGHTIANAIYFLAMYPEYQVRLQEEIDSILGDSDHNQTSYETHFDALSSGWIAAIMFETLRLIPGATTISRQIGPTPRTFPRAGSQRPVTLPPGIEFWIQIICLSHNPKYWSQPGKTEAESAITEFRPERWLPKSEDNTMFKPYNGSYIPFSIGARGCIGKKFAHVEFTAIILGLFREMSVEFDSCGGRKTFDEARLECLAEIERFEPKITLQPSGEMPGIKWVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQN1</accession>
    <name>A0A2T6ZQN1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1127848</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZQN1"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009365">
        <property type="term" value="C:protein histidine kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900745">
        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000099">
        <property type="entry name" value="Sensory box sensor histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAC" evidence="16">
        <location>
            <begin position="539"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="748"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1054"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1275"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1275"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="12">
        <location>
            <position position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU77744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1315" mass="144592" checksum="2A49D81F4AF362F5" modified="2018-07-18" version="1">MAPPLQDGMSGPNNSNGTRASITNNKIPGGKGGKMLDNLFIDPEHKSSSLPLPAFPYRHSSNRDVPTVQTYAAHPPLSNPPPPSGASLAFTALQFLPTPLLVLSQDKTVVLANEAMGRLLGVEPTGQPANRIGGTSPEPSITEILYGKRLGDLRFAVLQRRWPLWVSWEQFLDALASDIERGEGFQNANSLLNVSTEAPPSPEDPTAPQTLIRDAAIDVLFSTLGDSSEGKPRQVEAKMIVSIWVLDGERYFTLTFNSITPSSNAFNASSPNSEMAFFTTKGATADGSCRTTQPGASVPGLLLSGAPALSDISSVPSVLQKIARMKDAVLDAMEIPVFALWHDGSIGMANRAARDLQPPGRDAKNPEPEGFASRYNIWTEDFSRPLTEDEVPIARLLKNKKALPPQRIGTFSATGNKIVFDTCGEGIYDDETGEFIAGLVWLRDITEYEEKLVTQQETNELRFMTMCDSMPQLEVANLQIWTTRPDGYHDYYSKRWYDYTGLTKEDSLGMVEKSIGCHQEDMELVSKKWQHSLATGQDYTVEYRCRRRDGVWRWMLGRALPLRDPKTNEIIKWYGTCTDIHDLVEARETARRTRAQLREVLQHSQITLWAIDLSNRITLLEGGAIWEAANASKAVIGSNIYDLFKDCTEFLSPIEDVLEGRERELFSEAALYGRWLKTKYVPILGKKGTAGQYDVSYIGGIIGVSVDVTEIHNKSMELEARERENQVLVANESAAKEASKLKSEFLASMSHEIRTPITGVVGMAEILLDTPLEGEQREFAENIQRSANALLTVINDILDISKVESGRLDIEEVQFSLPLVIQDVTKMLSLDAERKKLQFDHIVDFGEFGENMTVIGDPGRVRQILTNLLTNSIKFTHEGFVKLVVSVEKEDEDVIVVKFVVKDSGIGIDEDVQQKLFQPFTQADSSTARRFGGTGLGLTISKNLVDLMGGSIGLASSLGAGTTAHFIIPFHRPQYQNGSAYPPDVSTLPDRLQSDLSVSCQSSDYGVSTPPESPVDPAIKQRARSASNSQKLLKRVTPPLGPSPENAEERRRTHVLVVEDNDINQQIAIRLIKKLNFSVSAVSNGLEALELLKEAVPNGAITTSATSTSLRPRRPDIILMDVQMPELDGYSATKIIRSGKLYSYPCTPNRHANVDKDLLQLSQTPPNLDSPVAAWLQDVPIVAMTASAIRGDREKCQEAGMDDYLAKPVRSATLEKMLLKWCQARRKPASPVPQTAVFPSAITTARPEDSIPVAVTEKGIVENPEIKDVGIIQRLSQETPRASATPNPFEKVYENAGSSMGGSGRKYTPGIERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRF3</accession>
    <name>A0A2T6ZRF3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taxilin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_118234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRF3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRF3"/>
    <dbReference type="OrthoDB" id="425555at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="22397" checksum="759292F149595251" modified="2018-07-18" version="1">MKRLERDYTKSRKRADQLQKEKDHSRSEMQKAVSMKNKLETLCRELQKENKRIKDESKKLAQNEQLKREELSNKFENTIMEIKTRMGEENDDGSRKVNAGVDELFKAKFKSLVDQYEMRELHCYSLIRTKELEVQWNLARYEQQRKQAEQEAHRAKALHAQVSTFSQTEAELRSQLNIYVEKFKQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRI4</accession>
    <name>A0A2T6ZRI4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_105971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRI4"/>
    <dbReference type="OrthoDB" id="5390231at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="286" mass="30803" checksum="A9B76CEEC0F64E75" modified="2018-07-18" version="1">MGHMPKSGATLFWPPSTQSTFLSGLKHFAGSQSCPNLALVISPCFPTSFLLPKFPPPQPPAPLSHFSVPVELLLKHKLEGKPNSAINMSDEIKNVIVTTTAHPTILPPLPDRATAGLSREDYQVAKNLRTVHLLIDLICQGSHGHHASFTEFNGMPPKSYSAKVSCTGDGTSWRVVMAPSGVKGMAWYFSGLKKLEGMFKTAVIRYWDAQQCESLVEAIESGGIESVPNNWRFVVHHDEVAGESENLAATSASQAAGTQDESMTATEVGNNDTTTEAEEEKSVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTC5</accession>
    <name>A0A2T6ZTC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_981437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTC5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTC5"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU78750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="501" mass="56210" checksum="73D863B1AEC6525B" modified="2018-07-18" version="1">MGSLNFGLVRSAVYLLGAWVAYLALLVFYRLYLHPLRRFPGPKLAAATGWYAGYWDLHMGGQMVKHLADLHKEYGPIVRSEPNQLHFSSPEAYSTIYSPTSKLTKDPALYHSFGASESVFTFLDPTTVRARRKVIGPMFSRRAVLSLQPLINGKIRKLCDILSGYADRDEAADIASGFHCAAIDIISQYCYSECLDSLDVEGFKHGVLVYAKATSETFWTIKYFPLVEWLLSLPRSVSLRLVPELKGFLAFRDTIEEQVNRYTKNPSLLEKSSHTSVYQRFLDPQVKGGTPSFSSLVDEAQNLFFAGSDTVSGALTFGTYHILATPGLQEKLFAEICRMWPVLGEEPTYEQLEKSMYLTAIIKESLRLSHGTVSPLPRIVPASGMTIQDQPIPGGTVVSMDAPTIHLNPTIFPSPDTFLPARWLDSGAKDLDKHLVAFSRGPRSCIGSNLAWAELYIAFAAVFRRFDMVLWETSKEDMEWMDCFVPHTKGDLKVKFKVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTE1</accession>
    <name>A0A2T6ZTE1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dolichyl-phosphate beta-D-mannosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1101190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTE1"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="21926" checksum="C674FC3180B5BA2C" modified="2018-07-18" version="1">MILTTPETTFIPPTYNERKNFPIITLLLEKTFTEHKLVLELIIVDDASLECTKEVGNQSITLDGANRLLKLLTGKLDFTTSNFVIIMDTDLSHHPKFIVDFITLRKTKHYDIVTRTRYAGNRGANGWDLKRKFVSHGANFVASAVLRPSIRIEIVLAQTQSKGYTFLMEMIVRARDEIVDHAKGMFSLWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTQ5</accession>
    <name>A0A2T6ZTQ5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1083145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTQ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTQ5"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="30987" checksum="24CAE3A4B1A134CC" modified="2018-07-18" version="1">MSAATKKYKSPIWAPGIFEGKVVLCTGGAGSICSTQVAALIQLGANASIIGRRKDVTEAKAAELQTLRSGSRVLGISADVRDYTMLVAAVERTVEELGRLDYVICGAAGNFLATVDNLSANAFKAVIDIDVLGSYNTVKASLEELKKTRGKIIFVSATLHYTGTPFQAHVSAAKAAIDALSGVLCVELGPYGITSNCIAPGPIAGTEGLARLSRPEIANEAQRAVPIQRLGHVHEIADATIYLLSPAGDWVSGDVIVVDGGAWHRQGASALPYPESVTRKGVVEGVKGMKGAKDSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTR8</accession>
    <name>A0A2T6ZTR8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1193053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTR8"/>
    <dbReference type="OrthoDB" id="5347748at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="509" mass="57203" checksum="A19C56506C566010" modified="2018-07-18" version="1">MASSNWFQTNPTVLHASPPAFPPPLSSQPPDPATVERAILNPPFVWKGVPLRSFRCTSDGDLSKLAPLEEKGHFLSVPHEKRYRSLKRNLYQDLEDLARRHKVENKLESAIRVAVEEREITDFHEDFTRRLEWGDESSSLLLGRDVFSDAMREDGILENGAAGLMQSSRERAREDPYVAVARFSENGQGSPFPSVRNYFRHYPGISISLTVTDFYRRLEQKREEFGNALEFQQMWEWSERHWNFFEAVSRLRDWARSKKANEDGTSEGSEVATNLGDAEDLEVIWWSPELEAEKRRHQWAILRRIIAAFKINEEDFPEICAPGGRTLECYFSLGKYGIKEKWYPVDRELEGKGKGGVKEAMERIDCFEGVLASGGSLAEASMAVIKRSQERDSRVTSGDHSTTPERDQGGSGEETPTQQDFIMQAVPDHPPTKDSSCSSGGTLVKGQGSLDPFDDSNGNAEMNTKASISTLRDGLIGAAARPGPPDQPAQGRFGSRRNPKARIRPPFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUU5</accession>
    <name>A0A2T6ZUU5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000096">
        <property type="protein sequence ID" value="PUU79261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUU5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="19276" checksum="C31663E88B326B24" modified="2018-07-18" version="1">MTHADGHSLIGGNADADKHKKSPDTAGSPADSQEAIEHCSDDRITEEAESAVPSPSVDSYQNYLKLVKIVDAKKGSTMGSDVGVEGNNAGMKRKANGEGSQIACGIAGRWDPDRTLSGLSRRWAEKSKLLGWQKQTDTPIESTPAYKIEAIETRITRPAEGCPKDHENPSQSGLKRMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV24</accession>
    <name>A0A2T6ZV24_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutathione S-transferase omega-like 2</fullName>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1081977</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV24"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV24"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000162">
        <property type="entry name" value="Glutathione S-transferase Gst3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000038">
        <property type="entry name" value="Glutathione S-transferase omega-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="17">
        <location>
            <begin position="176"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="16">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU79341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="330" mass="37952" checksum="26F890A53E011091" modified="2018-07-18" version="1">MTTPVQKHKITEWVAVDSKTGEFQRKASVFRDAISRAPGAQFPPEKGRYHLYVSYACPWAHRTQIIRELKGLQDIISLSVVHWHMGSKGWRFATQEEVAESPEMTAAPEPLNGATYLQDIYFKADPQYSGRYTVPILWDKKTNTIVNNESSEIIRFLYTEFDDLVDEKFRGNLFYPEDKRGVIDELNSWVYDTINNGVYKSGIATKQGAYEDAVTALFASLDRVEALLKSSTGPYLLGEKITEADVRLYPTIIRFDPVYVQHFKCNIGMIRHDYPAIHKWLRHLYWEVPAFKETTNFEHIKKHYTKSHTQINPTGVTPLGPLPHILPQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV64</accession>
    <name>A0A2T6ZV64_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV64"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV64"/>
    <dbReference type="OrthoDB" id="4506255at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="560" mass="63444" checksum="430472A65F4A6863" modified="2018-07-18" version="1">MDPSLNPQYLVALMHKPIGHTQDAESDHPTDETTDHDFAWGKKQCTFPVLDSLASVCISEPKHQVISLALQLRSLECKIRLIIAENGEVKESLVAYVRRIWAKLQELSEKSTHQITAEGNPKEGNPRERNNFKEEPVQPSATLDLFCEILKYTRQKSINSIQEWLGDLSTFLHRLWKVRKGKLQGHEIDLRITLLASERACRVLAQESLTSEDWEMAYNAMGLATRSAEPMIWDPIGCERLVHELKDPEGNTPFLLHHALNQITSQYRHFRALVEFSHSPHLRHVFTYKMSIKSVPKSENHSIELPTSKSEWSQIINNICMEFHEPSRGWQDKEAERAKLGFKQTWKISSHCECSLIEHLAKERNRNGKGKLKGLREATGGDVGYRRLEEDATSGQRGGVSTGIPQPEGGTIRTMPDIGGGCGRLMGVEKGERDGSSEASECESNDWSRVPPFSYIGISKPSCTPCCIWIAAYNSLGQQRFYTRGSCKKWIWPWGMPRFQSQQLKQHMVNMLSKEYIQRLEQEGKLPSLSDTSANSMEADSPWNPNIIADLASLLLAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV65</accession>
    <name>A0A2T6ZV65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV65"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="170" mass="19917" checksum="1C21836743C50103" modified="2018-07-18" version="1">MCYQLLLPSSRRSPNHTIHPPQSSDYIYPTSQNLKNNPCFPERIGSLIFPINQFQISSSFLSSFLLDSGAPLYIHSCTSLPFHLNTFFFAWLLFVHTIILLPLLPFFSLLFFHLSFFFFFFFPFPSSLLHARWLTLVFSFLFLWFGSVRKYGFYGRTDCSRVGLSYVTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVC3</accession>
    <name>A0A2T6ZVC3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_945036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVC3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVC3"/>
    <dbReference type="OrthoDB" id="5358018at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11907" checksum="F40F968A2CCEBDF6" modified="2018-07-18" version="1" fragment="single">VSDTTVWKALKERGIKPYREEFKFILKSENKLLRLAYCIERKDWTIVEWGNYGFTDEMSIEVGGLYRLHLVWRDSTERWHEDCVGAMKKQGISVMCWGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVE9</accession>
    <name>A0A2T6ZVE9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1100777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVE9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVE9"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015601012" evidence="7">
        <location>
            <begin position="18"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="69"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="700" mass="77105" checksum="9112F209E8A8D0B4" modified="2018-07-18" version="1">MDKHLPVLLFSLCAVSARFSPSLSGSEESYAALAREEILKNYDNNCIEVVQSMIHMGLHDFGSNNGHKAWMFAGMAVRMGAALNLNLENGRAKGAQTAVAREVARRTYWCYYLMDRLNSYGVARPFLTQDHDCHVQLPCNQPSFNDGKSVITEHLLGPNPYCRTSGTTYMGAMAFLVRAVGIWGNILKQIHMSAFELNRDKDTEFRRLIESLENWRKTLPTGLQYSNENLAGQIEVGTAGAFVMMHVMWHTAMAYVHRYVRSMGNLADLAGEVGPNNQVIQSIRKTFVHADAVLLIMSHVYERKLEAQAQNRSLIVNAPFLGQAISDACEISMIRARELKGEHGGAGAQKQRVFTGLGWLKELRKYWKPMEGIYKKLRKSCKALERNLSQPPSARLRNDMIPSPDSGAGSQELNSISSFPMFHFPIDAGMYDLQPHPDAINQPLQPMTSQQALPFAGIAYTVPERYYEAAFADHSMSLYTIAQEEGGFPNLYLPHTDVDMRASMDPMPTTLAPSSDYDVGMAGHGMLNSSSMPLVDLQGGYEHMDAQPDMPEGHDRNHELDNSELEDDEDTDNEGDGKAGETGSPAPNKKENSQLPSISTMYFHPTAVRCGGFSDVSGSDSSGPESRRPSEAAPVKPETNRMDLLHLLVTSEDVTQVVSRAVATQQSGTDLGTGKAGIMVPDDGTLVGEINVDNSNEDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVT0</accession>
    <name>A0A2T6ZVT0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1107595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVT0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVT0"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="305" mass="34966" checksum="D60E917C06281814" modified="2018-07-18" version="1">MCLENWDEREYYERLPFYWRSPAQNDVIMGGGVGRDMTFVLTELLNKHKKSKEILTIDEDDITCEAMLITDTIVGEEDRMKEVAKDAFLEELEKDELEAEHVRDDVFVGNRRGLRLAEMKAMLDAHESKFSFLQGHVKELEDNDKALTARVSTLSLAVYEYKQIRRRFISSFKVTKLPEAVEQSDHDLVREGNLVAHGGDAVVDALLYEGIGGRRDIYAFQQLYGLHPADVVKISHHETLNLLNLHAGIRADTRRTGSEEFYQRFAAFILAFQVSSQDTDYLLGNSVNTTRTAYEAVLDCQKYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW72</accession>
    <name>A0A2T6ZW72_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1100638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW72"/>
    <dbReference type="OrthoDB" id="2563506at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="11839" checksum="0A76A54E33C86B66" modified="2018-07-18" version="1">MGSGAGFYLPPPLNFSAMSGRQTSSAASSPTTRSPLSSTPPSHYSSSPYASSSSRNPGLYTSPSRTSLSSLQSFNAQEPAVLSDKVTKELRDYASSFDHVRDWKRRMTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWE3</accession>
    <name>A0A2T6ZWE3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_977851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWE3"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26010" checksum="3F83DB1A29DC9498" modified="2018-07-18" version="1">MHQTTLNDAALALSRVLTFHRIHHTFFGGFAILATGADHRESKDLDVLVSAPKSTITHILSDRRDWLEIPHAREDYVAYFWNSSSFSTSPLEPKHMVLVEMFVGQHDKAHFPESRNTVLKGCKMGTSYVPIANEDVLFRGKLNACASRGKRSDAQDVDYLVATYGERLKVVAKSLDKRTVGLAVRRHPELRKVLAELGVGTRGAVWGVRKAKIEAPAVPQMWDVHRGLGLECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWI1</accession>
    <name>A0A2T6ZWI1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWI1"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="320" mass="35075" checksum="BA186CB99AEECB2C" modified="2018-07-18" version="1">MPRLKLSTIPKSLSTHLFSPTLTSFLPSPSTATSTTGPPTCTTPPTTSFQILSDLHLEASQTPPNTYETFHIPPRAPYLLLAGDIGLLTPSHYPRYLHFLTAHVHKFRQIFLILGNHEFYHQSRDEALRAAARLESERALEGRVQVLYRRVVEVSVRVGGGEEEEVVCILGATLNTHVPEEAAAEVAARVQDFRMIKGWSVDAHNRAFREDVEWLKTAVAGLRRGRKAVIVTHHAPVVGGTSKSVFEGSSVASAFATDVVGEVLTAGGGEGVGTWVFGHTHFSVDFWVKWKRGRVRLVANQRGYFGEDEAGFDVGLVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWQ8</accession>
    <name>A0A2T6ZWQ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution/morphology family 35/apoptosis</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_777934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWQ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWQ8"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11990" checksum="75A2067F8CE391EF" modified="2018-07-18" version="1">MSILDNDSFDEYFDSSPSSPHVSAECAAAKSRYDSCFFKSYSERYRVGEVRMDECKNLFNQYKNCLDKALNTGSSPRDRSPPRVAVSPKRITDPDDAWKRMTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWV6</accession>
    <name>A0A2T6ZWV6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1124365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWV6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="133" mass="15171" checksum="699E88105CB8ED08" modified="2018-07-18" version="1">MTKLSNLTIYIIKFSGQLPLEEIEKQSEKYEELLEKAHLWEFGGYDDPFHFVKPEGGSQRPDGKGVNVTSDLFCHRAIRRDPRPDPPHAQGLNIGDASWKKNTAFLVTKFIKRGSQGDSTVHAQLFWQESVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWY4</accession>
    <name>A0A2T6ZWY4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1080553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWY4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015413106" description="Secreted protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7881" checksum="33EFD1B01F21FA3F" modified="2018-07-18" version="1">MKILLSFFPTLLLCSTSLFLTSGARINLSFFLFPFPPLPGQQQAVANMYTIGEREGGGGLPSSSSNSRKGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXN2</accession>
    <name>A0A2T6ZXN2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1079810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXN2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXN2"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="75" mass="8601" checksum="59FF9F4B6C84F664" modified="2018-07-18" version="1">MRSTVRKIFGDGMASALKPVWGFDEEGELRGMWRRSGQDGFWFMGGNFALARYYSRLLALQIKALEEGLMSYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY36</accession>
    <name>A0A2T6ZY36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY36"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY36"/>
    <dbReference type="OrthoDB" id="4638065at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="417" mass="46316" checksum="AD725782A07AD28F" modified="2018-07-18" version="1">MGKKRGRKGRTGNTDLAPVIPPPEPSLTPSTSTNIKTWREYLIGEGLVSEQVLERKIKAFPMKSERAKDYRDNLADNLSNFEQHIVEGFNLEEVTATAWKVSPHEAKIPNFEVNNEPTLKVLSGRNCYVLDGTDKREILAVKVATNGPPGVDTPIIPVALRQSIEDGIYRYLCSNPCCKEDATRHRSQAVPASPSTNNPPSPVKNEHSIQPFNLSSLHNIQENSNSSSQPPSSSSNPALHRPGGPANPVPPNLGRCHHIHAYTAAQLDKKIKNIKLGQSPSETWNGSRDRINSFHQFLDTMKPLTTLVQGVFKVTNPDMYNKYDRVYKALPKNNVEKEMKDCLGIWTSRGLVLDTMSDIHLDLRDVCKGFCAIIPFGPFEGGNICLPRLGISIPVGPGMLKIIFHLYFHSNTNLRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY63</accession>
    <name>A0A2T6ZY63_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_730327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY63"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="86" mass="9752" checksum="9BACE16673D7D63A" modified="2018-07-18" version="1">MPGLLINIPTTVVVPVCGSRGDEPSWSLILLSQYRFLGDVLTGYQTLLFFFFWLLSFLFSLLLRLPPAIAVALVFTNTPLGLHWYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY87</accession>
    <name>A0A2T6ZY87_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Orc1-like AAA ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_974811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY87"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY87"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="2">
        <location>
            <begin position="194"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="3">
        <location>
            <begin position="434"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="69242" checksum="C4A15F02C853973D" modified="2018-07-18" version="1">MAAIIPRSFQRSCRSLLFRTKSSQHGLLLPCIWQQKRWNHRSSVGGGNDYQFGPSSDLQPQPTTQKWGHVQDTAAPGGDQTGGGIRGSGMFHGSPDNGNGEGSGGGGRKPPKEEDKKHKFKGTAWKIFESAATTGASLAILGLAGYTYHKYYKKLVLQKIDHAFREGDPALNLATAGHSESEEPWVMLEAQNRIDNIVNGEEQGHYYLLIGEKGTGKTSMLLAAMHKTKGEACSMMEAHGDPEIFRIRLGKALDFEFHEDYIGSLFSIRGPRDTTALLDIERALNKLEKVALTRRKATGKPLIMIVNSMHLLRSDEDGKDLLDLLQQKAESWAASGLVTMVFNSDDYWVYERLKQNGSRMELISVRDLSKEKAIKALKNFRAKYKHEIVSMDVLERVYELVGGRLAFLNKVAREEDMIAKCKEICEIEKTWLLNKCGLLGTDMDDDVMDQQKFASSAMVLVKHLVDMEKEGAGECGHYDPEIGHELPEVPLYRARQIMTRAEFIQEFDHINIFTIDSKANVRADSVPMQNAFREVCGEPHFAQYLEETLARISNIESLGRTRELTIKANILKTSLQILDLWHGGKYNMTVKGYKGNVEKSVHFGVTRGEKVKEGEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYE7</accession>
    <name>A0A2T6ZYE7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1021227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYE7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYE7"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU80509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="221" mass="24291" checksum="35988A6C9F115975" modified="2018-07-18" version="1">MLVTKNLSPGESVYGEKRISVDTPSTEADGAPTKIEYRVWNPFRSKLAAGILGGLDDIFIKPGVKVLYLGAASGTSVSHVADIVGPTGNVYAVEFSHRSGRDLINMAKKRTNVIPIIEDARHPLKYRMLVGMVDVVFADVAQPDQARIVGLNCHLFLKEKGGVLVSVKANCIDSTAAPEAVFAREVQKMREERIKPLEQLTLEPFERDHCMVVGRYLRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYI4</accession>
    <name>A0A2T6ZYI4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1021271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYI4"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="7">
        <location>
            <begin position="39"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="551" mass="63109" checksum="33D3C0AFA8B1631F" modified="2018-07-18" version="1">MPTTSSDGNIHPQSTQAQPGPSIANQDTKPIKAQASPFQGWETYPRTVTGYDTLGRNGRVLSKSLSSDSERLFRGSADASIEILDVLETPDANLPLIQRKANSTTFENMLMDDRRFRFRCFHKTGKLTPSSTITPGNSWAKLPITEEMLRKLLTFYNVSPDFLRVIHFFGRRTRERISSSVAFRCIFKAKEADPTAYVSEICIRMAHVEKHGRVDPDMPNDDPWSVRQIGSYQRFDYEDSSSVCIHISPPKDVKSRLIEALGKGRFSKGSEHLSPMSLHLAFVTTAIQNWQSYVEYLESELIRHRECVLLTDEDWKASREDGDIRAGYSDFRKLQRYFRDKLLNTLSIFDLNMDVIQGLQTHKEELRSLRLLSDAAWSDASDILEYNACVLRELRRDTETILERTGSAAQLIQALFEIRNDTLIRSYTLATSKLVEMAQYTQRDSQLMVDFAERTKRDSGTMRVATILATIFLPGTFLGTIFGMDFFHSDIVMEHGKKRFAFSVAPQLWIFGVGVVVLTTVTVASFWLWERGLRRKDEDKVQQRRESWKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYZ3</accession>
    <name>A0A2T6ZYZ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1078782</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYZ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYZ3"/>
    <dbReference type="OrthoDB" id="5343171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015443917" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="32"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="49"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="352"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU80696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="563" mass="59858" checksum="2DAE98DFDC360BB4" modified="2018-07-18" version="1">MSYERLSLPSLWSGLSALLLTILLCIPTTFAYSPLQARQEGQLQGAEFLPKCAQMCVYNKLSQQPEFQSCNGQLGCLCGKDPERYRELLWSCIDDLSRCSPEEHKNTEDSVRSVCDKVLPVSSSSGTTASPTSTAPAATSPAKASTPQSLTVQSAEEKSKGSSGLSTAAIVGISVGVVVLLGLIVGACMVLTIMRNRRKRREQIRSMVLEPTSPRGPSGEWKVGGVSRSEWASTNSVDSNSGAGHYYNSKSRLTPIVTDIPTEKKKGAPAINISPVSPVSPNSKNVAAAAVAAPPPQIKVVASRKIMENHHLQIDLPPTFSYTPATPNLGEPVSPISPMSDFNRAQLAWASSGSVSSGNSCHEVPPGQAVTTDSLSVRSISPSPEDSNRHTCSAATMPRIQRERTPEPSTPPPQYAPANPALSGNTDLGRSSRNPSAAAAAGGGMARTDSIAWRRGLEEAAERAMTRVVRSEQSIQEEGAGERRRKSSIPGLDRFARRGSRDTRGDEESSLVSNGETGSSFWNRKNSRVSTPPRSPGFFNPGRRRDSGATGSKRSSADVGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZC0</accession>
    <name>A0A2T6ZZC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1100069</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000056">
        <property type="protein sequence ID" value="PUU80813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZC0"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="724"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="724"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="907" mass="99281" checksum="89BDBD7E7B375A39" modified="2018-07-18" version="1">MADITFGSNNTGNSSRRSSPGVGAGANGGGGGGSAGRRDKLGESSRPLKRRCVSNACIACRRRKSKCDGNTPACAACASVYHTECVYDPNSDHRRKGVYKQDIDNLKTQNTTLHTLIEAILNYPEDKVFDLVKQVRTCDSLEDLAESIIAEQNSNADPDGASPNSVATNDAEVDDDQPISLEAELSGKMGRLRVEDGQVRFIGATSNLLFVTPTPSSSEEDERGEIEGRNNSAIGRRIDIGEKDPITTWTTVTQDPALINHLVRMYFAWHYPYFTTLSKDLFYKEFLRGKNQPRSPGIKYCTSLLVNAILALGCHFTCVVGSRANHNDPATAGDHFFKEAKRMILENDEHEIPRLTTVQALALMSVREAGCGREAKGWVYSGMSFRMAMDLGLHLDPSSLKEGVGLGSGITDEELDARRVTFWGCYLFDKCWSNYMGRMPQLPSSMVTVPKPDVFPSEDSDNWLPYTDSGVSTINPQPSRIRAVSLRISMLCEISNDVLLSFYDSTPGSNTSGVVEFAATTINRIQQAGKNGVQAEFKKLGELFARLEDWRKKLPSELEAKEGSLPSVLLMHMFHQTLYIHLFRPFLKSSAATNSTLSHLDPRKACLAAATMISKYLRFYKRRYGLRQICNVAGYFIHSACTIHLLNLQQKAAKRDIVQGLKSLEEIGECWLVAKRALVIVGVFVHRRGIELPEEAENVLKRCWKEGRRFGLGAQVDKILNAAATTTTTKPSPKPRTTIITTGPSVPPSLAQAVQPPPLPSSPHPPRNQSFPTQSPPPPPPPSIPRSSPQPHPTHFYTNQPPTLAYYTSPPPNAQYLSTTAPLSPSSCASAGSPGSELLPEFGIDQGLLEQCDNWWWRDTAELANEMAIDAPVWPGTASLSVVAGPGSGTGGGFDESGTGVFNERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZY4</accession>
    <name>A0A2T6ZZY4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000051">
        <property type="protein sequence ID" value="PUU81058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZY4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8856" checksum="00CD7C2B23839650" modified="2018-07-18" version="1">MFRAIIATTWKHRKNFGIFMGGFASHWAVGAQATKIERCWNERQFPWMRTRGKGRGAEDSALTSPANTKTLWERWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Y1</accession>
    <name>A0A2T7A0Y1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_971924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Y1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0Y1"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="85"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="28265" checksum="4B36C20FD069A801" modified="2018-07-18" version="1">MADAAPAGGARGGAGGFGARGGDRGRGRGRRGPRRGAKSEEKEWQPVTKLGRLVKLGKIKSMEEIYLHSLPIKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVVIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLSVLPIRRGYWGTSLGDPHSLAAKESGKCGSVTVRLIPAPRGTGLVASPAVKRLLQLAGVQDVYTASSGSTKTLENTLKATFSAVGNTYAFLTPNLWKETKLLRSPLEEFGDQLKSKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A143</accession>
    <name>A0A2T7A143_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1106350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A143"/>
    <dbReference type="STRING" id="42251.A0A2T7A143"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="31132" checksum="1CE7277D39A64D80" modified="2018-07-18" version="1">MLSTTTSKPPPAAPTTAPAQPTYILRGHTTQIHSVHFYSSNTRLATADASGWVVLWSLHTRRATAVWKAHEGSVLKVSDWDGKIITHGRDNKLFVWRVEEEGMDVLLPVEDEVSWRRRPWLVASLDVNALNFCGFGGCAAAAAAGEGEGGYLVAVPAPLKAEDVDVMRLPDGARVYAGIRHEGVKTGMAMALSMFFYSGDNNLVLVAGYESGHAVVYKWDTEGTWKVVYTHKPHSQPVLSLSISPTPGTNPYFMTSSADAVIAKHPLPILTPDTPGNTPRPTTSPSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A166</accession>
    <name>A0A2T7A166_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1077047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A166"/>
    <dbReference type="STRING" id="42251.A0A2T7A166"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112327" checksum="C8C94A86A247976D" modified="2018-07-18" version="1">MESSAISLYFRLMRRETEETESVPHEYLINLIDSPGHIDFSSEVSTASRLCDGAVVLVDAVEGVCSQTVTVLRQTWVEHIRPILVINKIDRLITEIKLSPHEAYVHLLKLLEQVNAVMGSFFAGERMEEDLKWRETLEARLKEAEKPNPANPGGIKKGSNTDTPTSEYEEKDDEDIYFAPEKHNVIFASAIDGWAFTIRQFAGIYEKKLGIKKSILEKVLWGDYYLDPKTKRVLQQKHLKGRNLKPMFVQLVLDNIWAVYTSTVLNKDQEKIEKIVKSLELKILPREMKSKDTRSLLSTIFSQWLPLSSALLVSVVETLPSPPAAQKQRIPAIISSAPGSREISGVVQDAMVEFDKSEGAPVMAYVSKMVAVPESQLKKNQRVQLTAEEMRELGRQKRIEIARRFASENAGDPENKSGADDTGPADAPQDTTEGDQEGPKEAPEEAEDKEHLIGFARLYSGTIKVGQELYVLGPKYSPSHPDQHIHKFRVTDLYYMMGRDLQVLDEVPAGNVFAIGGLEGKLLKNGTLCSMDRGGINLAGIGLGAAPIVRVAVEPKNPSQLNKMIEGLRLLEQADPCAEYIVQESGEHVLLTAGELHLERCLKDLRERFAKIDIQSSAPLVPYRETIVSAAEMSPPKDPNLPRGRVQVITTAKQVSVRIRIRPLPNPVTEFLVENIASIKKLYSERRGSEEAAVTAEDGISADLEESDGTQKVKVLSLKEFKEGLKKSFERVGQEVWNGVVEKIAAFGPRRIGPNLLIDATRKGLCRKLLHDNASESQRTQAIEDVEATPDIARGLEDRISHAFQLATAQGPLCHEPVQGIVCFIEEAINSPDDENLEGAAARSRSYEIIASVRDAIRRGFLDWSPRLLMAMYSCDIQASTEVLGKVYGVITRRRGRIVAEEMKEGTPFFTIKALLPVAESFGFGDEIRKRTSGAASPQLIFTGYEMLFDEDPFWIPFTEDELEDLGELADRENVARKYMDAVRVRKGLPVQKKLVANANKQKTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1H9</accession>
    <name>A0A2T7A1H9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1113343</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1H9"/>
    <dbReference type="STRING" id="42251.A0A2T7A1H9"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="156"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU81588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="482" mass="52263" checksum="3D868203A9CA87D3" modified="2018-07-18" version="1">MACRRLAMRRLPLAVSPRAPYMSTAALSATSVSSYRQASIRSFSRLSQYNSGLLGSASKRSQQFVNASPIFNAQVRSYADMVVKVPPMAESISEGTLKQFSKQVGDFVKQDEEIATIETDKIDVAVNAPEAGTITEFFVKEEDTVTVGQDLLKLELGGAPKEGSGSQETAGEEPKASVDAAPQEPESKQAPPKEQHEEGGPVSETKQEPTPSSPPPAPEPPKQTEQQRPKPEPPKPATPSKGGFGNREEKRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSALVEMRKLYKDKVLDKTGIKLGFMSAFTRACVLASRDVPAVNASIEGPNGGDTIVYRDYVDVSVAVATEKGLVTPVVRNAEALDFVGIEKAIAELGKKARDGKLTIEDMAGGTFTISNGGVFGSLYGTPIINLPQTAVLGLHAIKDRPVAINGKVEIRPMMFLALTYDHRLLDGREAVTFLVKVKDYIEDPRRMLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Y4</accession>
    <name>A0A2T7A1Y4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_574306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Y4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="18395" checksum="CF6A89B416421451" modified="2018-07-18" version="1">MRSQCQRMLRAKYPRPLTYLPVSSLGGEPPLLEYIKTRTQPIPFSSKFSQKLSIPIPRSIPVLSFPIKALANRRHHRGVFWEYNLQCLWHEVNHYSRFSQSHNWLLCYYWYCAFNGTTPLRFCAHGLGCDFVKKHSSGTVPCSTGLELRVLRVVSYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2A7</accession>
    <name>A0A2T7A2A7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DOPA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2A7"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19980" checksum="2879E1061BF2C53A" modified="2018-07-18" version="1">MADPSTYNYPSPLAGYENAPPLPVTFNPDGKSFQNERTGKLSAAYERFPEPIENGQTSGGFDAHVYFYRNNPEQVQFAKELWERIRREFPELRIYKIFDEPVGPHTLAMFEVDILTPVHFGAFVPWLVINRGPLSVLLHPNTDDTLRDHTQRATWLGKEVPIDIGLLRKLLGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2E8</accession>
    <name>A0A2T7A2E8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1042212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2E8"/>
    <dbReference type="STRING" id="42251.A0A2T7A2E8"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="62242" checksum="DD8A420582F3699D" modified="2018-07-18" version="1">MAHPHKIVVGLDFGTTYSALAWASTNLPGQINLIGNWPSAGILTHHSAPTEIAYHQGSTTDFSWGYDIPRTARRLKWFKLLLESNDEHVQSGTPLPAGMTAMDITRDFLSALYQHAIGTLWRQNGQAVMSMTKVDFVLTVPAVWSDTAKQRTREAAIAAGMSNEHNLSLLSEPEAAAIYTIKNQDRNAINVHDRIVVCDAGGGTVDLISYTVISINPLKVTECAVGTGDFCGSTYIDRNFEVLLQQRMGHHYKNLRVETQQRIIKNFEEVKCAFRDKPDQSVYHVNVPTIDSIPEAGIFGGEFQLTREEMKQLFDPVVDQIMILINSQVQSICSEGNQVNSVLLVGGFGESPYLFQRLETWCRQWGISAISPHGAATAVVKGAVLRGLEPSIPFQMSTVVRRVRRHYGTPMSTPFIQGRHSERDAYSDPITGRKMARNQVAWFLQKGEPIADDRRITRNFCRSFKKYSGPWIDSMVACDLDRPPSRVTRDVKHVCNITADLSSVSKSCYEKKWKNWRKYYIARYNLDLTISSGDMKFELIFKGASFGSISVDFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2P0</accession>
    <name>A0A2T7A2P0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translational machinery component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1075929</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2P0"/>
    <dbReference type="STRING" id="42251.A0A2T7A2P0"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23532" checksum="8F5ADE5BFFC6E84F" modified="2018-07-18" version="1">MPFRIPPLLRNGLHIRLPRPTLPPQPNHQSIPHHRTASLPPMTPTPTLPSNPTTTASTTTTTRSSPIPFTPDPLDDDGLPLIGDYPTFSETGGSIDLYHLHVYSPRHNCHIAYTKPNNDCIISKSTGNVGIKGAAKGSFDAAFQLASHVLGKIAEMDAVPRNLELVLRDFGPGREAFMKALMGREGQFLRGSIRRVTDSTRVKFGGTRSKALRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2P3</accession>
    <name>A0A2T7A2P3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Restriction endonuclease type IV Mrr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1076007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU82017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2P3"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20894" checksum="B5E4725F4F336C55" modified="2018-07-18" version="1">MSLERTGGSGDKGADLLGTWTIPNLPSEQSQKPRVYDALVQCKCTKIGPAAIRELDGTVLSKRPETVGILAAPKHCSPGIRKHMAMSPRPLMYLCLRKKKGIVEQIIWNTPASVLLPGMGVRPIHLKDRTEIVLTIHEYEFRSLLSQNLSEKETVEGAKNGKEKEETPVVQSGSGDTTPDITSMEYGKGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2V3</accession>
    <name>A0A2T7A2V3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_939610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2V3"/>
    <dbReference type="STRING" id="42251.A0A2T7A2V3"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16558" checksum="3E7E7E9E4675D757" modified="2018-07-18" version="1" fragment="single">QRFTTSRRLPHPPRSLFNLVADIDSYHKFLPYCLGSHVTRTCPRTNLPEEAELRVSWGSFDETFTSVVACSAEAGTVEAKGDRNDLFERLVTRWVVKDGGEGEGEGGSVVSLSLEFGFKNPIYSAVSAAFTPKVAAIMIEAFEKRAGEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2Z5</accession>
    <name>A0A2T7A2Z5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">B9Z19DRAFT_1075856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2Z5"/>
    <dbReference type="STRING" id="42251.A0A2T7A2Z5"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU82117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="386" mass="43565" checksum="385F30168F02037F" modified="2018-07-18" version="1">MRFTLFHFFYSTSFTALFLLLAILVLISPADTIVQALLRNERINNVFIVAGCYVLTALIALIIYISRIYSVRRLMKDIPKFRAPVKKVYLRARVHKAVTANLSRSAIISVQSRPREGGEGVWGEIKHPGWSGGTGQLPNVQYLSVVKELPNLLEMEALSLCPPGSSGGGLRTPAPSGFEGITVPDQEVVRRQPHMSFRAYLNQLAAVGYVRQDVADLFMARYERARFRNQGEGIEEREFMELMHIFAGLLRTLGDDLFPDSSFTSERRRSWEPRDEDSNDEDHRERMELERRDRYNSFGYETTSTEHEEGQGLRSTPDRPNDNSITGARRRQTGTIGPANISMRRTTTATTAGSITSPEDNEIEMVSLRPRGNRRLSVRTSTGTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A335</accession>
    <name>A0A2T7A335_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1075649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A335"/>
    <dbReference type="STRING" id="42251.A0A2T7A335"/>
    <dbReference type="OrthoDB" id="3546279at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="438" mass="49050" checksum="C3723AA94B56F7C3" modified="2018-07-18" version="1">MPPKRMHTKSRNGCMTCRRRRVKCDEIRPICSNCTRRELDCVYAAYCPPGRPGISNPPLSPRLRTLPLPLPLQESRTPASTKPRRSSTTNNPSAATLAALAKQFDALILEARAKSPSPLPRISLSKGDLDNLSLLHHFTIRTYNTLTNDGTREDIFRVMYPRIAFQNELTMYSLLAVTALHRSKTAGASLVASRYQIIAASYFDRALSSLRIAILDSSRNATALFAASTLIAIYGLGCHTTGSEPNHIPRVFTWIPLVKGIKTIIKQWWAPVKQGPLARLTEQGALELIEVDNGPLPLPASLFNLALETPPTSNTPYNGDEIVDAVSASIYKHVLGELRTSWTNFWATGHRTAICIQWLVLAPDEYVIYLMEGRPRALVIFCYFLCMIKKLDGLWWIKGSAEETFIQIEGKLNTRWKEQWLKWPKSIIMGDCEVVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3R6</accession>
    <name>A0A2T7A3R6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1041158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3R6"/>
    <dbReference type="STRING" id="42251.A0A2T7A3R6"/>
    <dbReference type="OrthoDB" id="4739136at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="461"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="911" mass="102400" checksum="944F19DBE58DB94B" modified="2018-07-18" version="1">MDYELLNAQGWDDDDTPSPREPPRAPRSVKRRGAKSKSQTLQPIPDLVTLPADTSSHSPHPANGEIQLTDSSSRLASNSTASKPQKNHLSQDSRYYTDPKSPSGLEVKYKGPRSQPDGPSASERPFVTKNRRSYKGGYYKGDGPAVIGQSMFGVPALSNVFQEQGGVGEGRGSDPAEFVASLDGFVRDSTNDKRARDGDPADDYMSLPVRRPTQFDESFFGLRNNHLAYIAIKTNTHLSVPESSDDPRIGIWGTKEQVEAAKHDLNALMQHIMHELETETRRAGGNWEKVKAAPSERKQKWLDRQANDAMLRKKYRQQPPADKPLPFNGVFVWPAKEIDPQQTLGTSFEALDDIRYENKVYITMSRAEGIFHVAGEDEALVNAGLERMFGVFCEVAARNRKPNRKMLVHPPSSNPRGATVKLIMEHDFTDRQVTIKRLKTNLGPMVRLSTIPPKAGWLEMWKTKRAKLEKANYIYLKKVVQQGLSDLLYYRGHSTMKVHFGSLMLFSYKAPERGQEFELLEFCEMAKNPQAAGELIRHIGGENVAKELIHECFVRHDLFQPTNTSDFMFGDNAYDTNITNGAPAGLHPHETNMEPAYHATLICRTHDDKKCTNDLRLEVKFEKIPGVHPIGVANSAGNLYKVGTRTWIQLAPGAGGPIKAGDHSTKQRGPFDLKVMDLENDLAWQFQLLTHSLTRDTDIYPIFSEFVRKIRIEEIPDVLDPVGQPVGGAPDRRRLVPRVSYVNLPGMTVEALTLKTKHQFWIKGTTYQFDITKYEHFDTDEIRSAYPDGVQNSWNGLGTIPDTRWGASFSNSEWVTTMAHQRGLGVGVCGPWNPNVDSFFKSSKVGGFEHPDFTRTNAFHADPWKGDGFKECITRIQELVRFIADIRTKVEKKEAERIAKTNFAGCEEFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3S0</accession>
    <name>A0A2T7A3S0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3S0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="9063" checksum="BB005F13ECF71BB4" modified="2018-07-18" version="1">MLYFIFQIPTFAFTFSFLFFSTFVLYAALLYQYSTCAMWWRSYHVGSCGFDAVVSFSGVFFIIFSPSHFFFPRSCGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3U2</accession>
    <name>A0A2T7A3U2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1041110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3U2"/>
    <dbReference type="STRING" id="42251.A0A2T7A3U2"/>
    <dbReference type="OrthoDB" id="5362733at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="528" mass="58280" checksum="5019225C11E13E1A" modified="2018-07-18" version="1">MDPLSAVSGITGTVAVGAKVLVALHGFAKGVKSAPEELKLLARELEHLCNVMDNFRKKTRGQIVSQGIEDISGAILDIFIQLNQLIIEHTVSEKDGFLKKGWKQVKWHYIEKDIADLRAHLNSNKENLLVALGLGNELQNGHSNMQLERVQEILKEVIERLQDHDMQTVATCESYALQRWQEVLSTIAPSSRPTTPNDQISVARSESGMLSEAGFSERSIPMSAYQFNDMETRGKGVLISDGTQAKAYTVKARKQKAGAPNAGSSKPPTKATGPALLARIPEPEEGDEVLDVKDDSKPGMTIDSQTFIKTPSKTGGPKPRGALRRARHRLKNFPKKRRSKVDLMPVPTEKGQVTPDEIHNTPGFSIEKFLQDRKYSRGLQKPLRKTHAIWPPVHSGEWFAVTPNEDGPRFLECVDDYAMSRDDTYILKADQRVRVITYLESGWFLGQVHPDGLVLQFPSAHFRRTTSPTNEELKRLEVQQIEALVGSDGNGKRLDDKLGIGGAISSGIPGLEAYTAMQSAGLNTIVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3W5</accession>
    <name>A0A2T7A3W5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_415225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3W5"/>
    <dbReference type="OrthoDB" id="10595617at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="16346" checksum="EC4216D478FB5C79" modified="2018-07-18" version="1">MVESWVFFYIEDGWNYLMESGYGNSFSSLMVFVLRGFFSSFPSSILFPLSSGFFRGELFQGHATHHFSSLSSLSLANDTGAPWYSHCACLSEIFILRFLAFAVTLWIPYGRVGYEKFRKNGITTSIIHSRCASVTGPNQGFDDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4G9</accession>
    <name>A0A2T7A4G9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">biotin synthase</fullName>
            <ecNumber evidence="4">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1074444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4G9"/>
    <dbReference type="STRING" id="42251.A0A2T7A4G9"/>
    <dbReference type="OrthoDB" id="2414104at2759"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000011">
        <property type="entry name" value="Biotin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="BIOTIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976:SF2">
        <property type="entry name" value="BIOTIN SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01060">
        <property type="entry name" value="BATS_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00272">
        <property type="entry name" value="biotin_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01278">
        <property type="entry name" value="biotin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="15">
        <location>
            <begin position="91"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU82585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="398" mass="43461" checksum="6CFDD62C69565ACC" modified="2018-07-18" version="1">MNRIVHFSTGVMRMGMRMGVRAGTQKRWLATHAETPAATTTGDGKTLLEKALNAPPKNTWTKDEISSIYNTPLMELTYAAATLHRKHHPHNTVQTCTLLSIKTGGCTEDCSYCAQSSRYSTGLTATKLSTLETVMAAAREAKANGSTRFCMGAAWRDMSGRTRGLERIKDMVREVRGLGMEVCVTLGMLNSKAAEELKGAGLTAYNHNLDTSREFYPKVITTRGFDERLQTIENVRNAGISVCTGGILGLGETAEDHVSFLHTLSTLPEHPESVPINALVPIKGTPLGENKKVPFDSFLRVVATARILMPGSIVRLAAGRINLTEEQQVLAFFAGANAVFTGERMLTTECSGFEADRRLFEKWGLVNMKAFRGEENEGAEVVAEASRSGKVEEVIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4U9</accession>
    <name>A0A2T7A4U9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_350076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4U9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12972" checksum="9B96D77A968BE88F" modified="2018-07-18" version="1">MIGYSRTPLSRMVKIRSETRGGAYVGSRVISGTQIRRGSILQYSVQTQISRVTSNVNSCSYTRCVSLFPTLHTNRHCPRHEFTFRNSETSGRVKWSMKMVSEKTKKRVIIEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4X2</accession>
    <name>A0A2T7A4X2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1074216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4X2"/>
    <dbReference type="STRING" id="42251.A0A2T7A4X2"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="205"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="549" mass="60905" checksum="519F89BFED0E782B" modified="2018-07-18" version="1">MARRIVRTIIQLILLSVTFVTVLFFLDIRYSLLPTQIHNLLPEHHAGQVITDITYESCPRISLLSCAAKEGWVRIEKDLFLGKAWLTRGYIQFKRTKEEELNGEKFIVDIRVKRSEPAASEGGGDARWESRPGGIWIKRSPKVIDDAVTGVDVLFGPDAAEVRPGWVLREGSLTVGESPRITVRKGAPPAGPKKPVLKFRSDHKFKIIQISDLHLSTGVGACRDPEPVETADGCEADPRTLEFVGRILDEEKPDFAVLSGDQVNGDTAPDAQTAILKFAELFVKRKIPYASILGNHDDEGNLGREDIMKLTASLPYSVSEVGPPIGERVLDRKGREGNEGGVGNYHVEVLASKGGHSALTIYFVDTHAYSPDENNYRGYDWIKPSQIDWFKTLVSTLKDKHNHNPYNYIHLDMAFIHIPLPEYRLAGRPIVGGYNNAPREPPTAPSFNSGFKDELVAAGVSVVSAGHDHANEYCLLDEGKESLWMCYAGGSGFGGYGGWNKYQRRVRLFEINAPLGRITTWKRVERGPEKDKKIDEQILVEGGGAAQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6D1</accession>
    <name>A0A2T7A6D1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_161551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6D1"/>
    <dbReference type="STRING" id="42251.A0A2T7A6D1"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="13394" checksum="0420B8CA7B0F1C1F" modified="2018-07-18" version="1">MSTTTNPQEDTPLTSSFDSLHSLNSTSDYSATLIHHNHNHDHRQRRPLPPIPDLRFEESYLSGIAAANGVWWKILLITARDQMILPLLQGLGYNLLLIGWWRWNERVMWGGRGFGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6D6</accession>
    <name>A0A2T7A6D6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1098690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6D6"/>
    <dbReference type="STRING" id="42251.A0A2T7A6D6"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="463"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="808" mass="87706" checksum="5B7839E88C766F3D" modified="2018-07-18" version="1">MASRRLSDLIAVFSASSTVARKHYLIRTQQLNLYASTSSILKSSYGSQNIAPVKPKLVEREGIGQGYFYRPGDLNSLDPASKEDLSGTQKQADNNPLPDGTTPPSKTSTHFSNKEEGGEDHYSDQPTGVPKGSLSKGGLKLGPQSSKPSTTPSPRTSLSPEEAKRLDHESGTSISSVIEEPPDQVEAQGIKDDNIMFYLRQARASPVLSSFPSVKIPRQAEGEQGPSGGTNSDIFYTAPKKDSKTSKASEKVVVPEQESGVEGLNGELFHSRRAKSLFTQSRGTKEKTLEKIAKTQRDGVKLTGGRDQDTFYTKASTDALPETSTTSPAIISASKQEKSGIEDLASEISKNVGMASTAITEQVEKPAFQMSASRVPSSRLGRLLHYGGLAAGMAWGAAGESLRRATGGGDSGSTSGAMLSPANVERLVEKLSMMRGAALKLGQMMSIQDSKMLPPAIQEVLTRVQDGADYMPPFQRDSVLESNLGPKWRDLFSAFEEIPMAAASIGQVHAATLSSNGLPVAVKIQYPGVAASISSDLSNLAILLTASRLLPKGLYLDKTIANARVELAWECDYLREAESAKRFAILLQNDTSVFKVPAIIDEACGPQVLTMERMGGVGVTKIMSKLTQQERDFIGTQILKLCFREVREFKFMQTDPNWTNFLWNVEEQKVELLDFGASRAYPESFVHTYCALLKAGACSEESQIRDLSIKLGYLTGLESQTMLRAHVGSILALSEPFSINAPEVYDFSDQTVTDRVRGFIPLMMRERLTPPPEETYSLHRKLSGAFLLCARLGSRVPCRGIFEEVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6F7</accession>
    <name>A0A2T7A6F7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6F7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="18144" checksum="BECB85AFE7193E60" modified="2018-07-18" version="1">MSEYCHSLQNSFHGRYGHDGEDVSDLDNDGVHEYHYHDHLRDLYYHSIHKHYHDNLRSLNLDNLHSHANNQRQYNLHINNNTNPTPSDNNKPGLNPHPHYHRPPLLSAHHHNNQNAYNHLHNHEHIPLPNHSPTNNHDPNNNNNNHPLTPPGNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6K4</accession>
    <name>A0A2T7A6K4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1073131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6K4"/>
    <dbReference type="STRING" id="42251.A0A2T7A6K4"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="143" mass="16988" checksum="8C860A2D419C2097" modified="2018-07-18" version="1">MGSVVLPHLKTGWHVDQAIMSEDDRLVVIRFGRDWDPDCMRQDEILYRIADKVKNFAVVYLCDIDEVPDFNKMYELYDPLTIMFFFRNKHMMCDFGTGNNNKMNWVLEDKQELIDIIETIYKGARKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6L4</accession>
    <name>A0A2T7A6L4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_964911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000014">
        <property type="protein sequence ID" value="PUU83360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6L4"/>
    <dbReference type="STRING" id="42251.A0A2T7A6L4"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="914" mass="100130" checksum="3452D65F5CAAA6BD" modified="2018-07-18" version="1">MAKSRISRIDGDSFDPSFGWETINFPDPTAHSSTHPSSPGTPYAPSGFQHGSRGGGGHGHRHSPSGTEEFSRTRHGEPVFSSPEISPQIPAIPEDGIPESLRITSPLSPNFPHTGSPLLNSPYAAASAQTYGFQTNSHKRRSAIRDSVPQPPPPTIGGYGGNGNNRNSVGYDIPAPPPPPTVPMDFDDTDYERVRLTEHNRISHEGGSRGGGYLAPGGGWGGPGRQPSMAKRLGDKILGTVKGRGPGLSPSSYMGTIRDRGGGYGDGRGEGHYAKVDEDDGEPVGYDISSFGADFIPAPAARAMEDYKMDADYAYTGTGEVIDLSSFGGGGNSNERRDSDVFSLHRAGTVENSDKQSYFFPPTRVIPNWKPISMRPWFITGLLLISLALVVCVEALYQYSNRGLIRKGGKRGIISFKKVDKDLTVITFAMWKYLPTLIAVIYGILWKITDTEVKRTEPYYQLSKGSKGALAASTLNIEYQTFWSLLVPVAAIRHQQWLVVVSSIASLLAFALVPVLLSVFIEITPSQRARKKMLDPDTGKPRPDWDIEKTIVVNQYFSRILEATVGIIIFLGIGMLVVLSRRRSGLLGDPSGIAGVAAMANKSHILMDFKDLDSASEETIHKQLNKRTYVLHKGALWQAQFLKENERDVNAPKAMNPHPLILRLKGGLPFIAFLATLCGVLTPLAYGPFGIVVDETPWVLTLISVLIKSLWEIVEKDMRMLEPFWVLFNRHAPSSVLTLDYSATIPGFIVLKAASKGHFLLAWVGFVSLLVEVLTVVMGSLDSTGGEESDLSFTVSFVLGVIILSVTILTMGLVLHLRRFPFLPRQPGTISSVLAFIHQSKMLVDFEGTEEQSTAMRKKKLRRLGHTYGFGWFKGRDGKRHLGIDHEELLETYKFGKNALDGVIEGPNWDQYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7A5</accession>
    <name>A0A2T7A7A5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1189521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7A5"/>
    <dbReference type="STRING" id="42251.A0A2T7A7A5"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="15685" checksum="6273024ECC0C3C72" modified="2018-07-18" version="1">MSDTKPSSGKTMCIWALCLSGYYGEAHQVMSRLGEIKKGLRGYLGDKETKGNLVRDLVLPFTSKKTRILAGNGSAEAELFKPGALPTADGRISTVPTEIMSLASEVGDSSLVYKFMSVVSIILYGLHEQPSVLSDYEAFFPLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7L4</accession>
    <name>A0A2T7A7L4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_962638</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7L4"/>
    <dbReference type="STRING" id="42251.A0A2T7A7L4"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="10">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="15726" checksum="701466674202AECE" modified="2018-07-18" version="1" fragment="single">GGKNRRRGKNENDNEKRELTFKEDGQEYAQVVKMLGNGRLEALCFDGEKRLAHIRGKMRKKVWINQGDIILLSLRDYQDEKGDVILKYTADEARSLKAYGELPENAKINETDTYGHEGADECNFEFDVEAGDIDIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7N4</accession>
    <name>A0A2T7A7N4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_750906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7N4"/>
    <dbReference type="STRING" id="42251.A0A2T7A7N4"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="17215" checksum="87C6D5ACD09CECFA" modified="2018-07-18" version="1">MELVNKYYSHRKSLFDPFPTLGDVEKGCSYTLFTLRLFKNRTVIAGCLLGFFYSMAYYLSLQPYFYSYLMVARNTGSVAAGHITLTFSFVATVSSIVISLVIKYTKHYKYYMVGGILIYMLGIGIMLRYRNIDSSNTQVVACKISNNSSAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8P0</accession>
    <name>A0A2T7A8P0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1071022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8P0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="61" mass="7049" checksum="5E457BCBC1F83CBD" modified="2018-07-18" version="1" fragment="single">MISCSLSHPHKARIGRVDWRFTLLLLPPPKTKVQKKIHNGNVNRGIIFNLRFFLLSPQRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Q1</accession>
    <name>A0A2T7A8Q1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Q1"/>
    <dbReference type="OrthoDB" id="5404498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="811" mass="86144" checksum="DF209FF9E183A8FA" modified="2018-07-18" version="1">MPPSSLDQFPTNTLSTPVTPPTNSDSTRLVTKSTTSGGYRVLTSIMSSSSLSPPSDTDMELNEPDLLQRLRQRRKELDAEIEAFRALKESEYKAFERKLREEYELRERKQGTESDNEGGQISKNNNATTTDASPPYATVANTATSGPENGNICSTWAGVERGSQVPPGVGEPTLDDALRLELPNAPSAQLLKNYGNNSPPFDKDLQAAFTPRYLPLLDKNYQSPPSPPSNKIMSSPPQSPKPALPRIATIPGRSGNSPGSPAAPLASSLKSSSGSSFGTTGKSTGIKQKSPKRVTFQFEDESSVPSRSSPPPAKVHWSLADDRDSEYGLEDDDESVGSTGGQEVVGAGEELGGSGKVAQIGNAAKLLNREMTQGVELVVPTTLPETSTESKVLVDDSFEEVQFGDEMSGNRSKEVNGDLEGVFDTETMDDDEEDLFDMDETVAEREESPPHRDYAALLNTTKPPPQRSPFSGQSFPPLPSFTPIPASAPAPQADLSLTFGKALGMRSGFTAVRGGISASFNPSLSLEPITSRALAGEEPHTAPIASSLPNIGWEEISGKGRSVPTPGGRFRRRSIAKYDVPDEDDVPKGKSHPNIPEEDEPPLKPFGRSPGAASLPMAIARNSPLAALSGSTSSKSPTPLRKYASPATIPEVPDEAPVSGRPSPVPPPLATDLVLNPGVESIKQVSSADILAEMPASEPPSSTTAKNDSVSSYRLTSPFPSASVLPTASPYRTAYAAEVAASAFDGELESVVGGVDGRTGLDPDVSSFQAAPGTSINRRRGSVILPQEVRPERMSLGMRMAFEEMKGKKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A920</accession>
    <name>A0A2T7A920_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1037549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A920"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="811"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1134"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1729"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1729"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1743"/>
            <end position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU84224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1788" mass="200271" checksum="1EF563B3D0A57609" modified="2018-07-18" version="1">MDPAMQLQTIREWYAKLRPVRVDLIGDYAGEEFFVIEGDSLLRWVFADERIDFDTGFQLLHAVYVVESFLQQLSSRRCRFSVVFLDISRNACIPCSPTAEQNAWKYLFARSAIIEHMKRIDHPQDLVFTFESLADPKFQKYLDSTRPYFVMCHDGTDAGNIKKALKKPDWEAESTNERENGSDTEGKDTTDSPQVECVDSDLDGGFNQEGLLKAGIREWTSLGFCIALMNEIVFKDSKIFTYVLETNLYTLAPVDIRVNPAETPPPGPEYPQAPDWESLQSARERLAVAAIAHALRLDEGRCEDLASIFLTHIILLSQLTLPARFLAPFDVDEAVSAAINPIRDFLKQLVIVSGDLLRIGAVPFDSAQNDLCDYVDGRLLLKLILTPKELSDEVKEKFSNLASHVEALCGRRLELPVLPKSVNPSFTELPAVRRCKILAFSNPAFDKYLEKIRLPVDIMAEEGSEDHEEEGGQTYVEKTHWHNPRNPLVTARIRAQRALPKPVAKVRGAVAVAPGGKTQDQDRAARRAAGRARKWEQVYLNQMYQYASSLTDSIDGSLNPKLVTVGEKAKKPQATGKKTTAKEEKNAKPNKKDGPSKGKGSGKLSAADIISQNNATKKAGREAKLQDSWKTTCDEVASIADDENAISRLETWLAASQKAIAAGVAENKEWPFIEAEARLYKIQLLQRIWTGYCRRKQQEHGYAAASALFNEARLVLFSGGMTRKVHQILNNVFEALGIPKPPSDPLASLPDRKILFTKVWDGKCETLDIRLGLTSEEFQLLHCGPWMDRNMDSQPDPRVPFKPDGWQRKVLDELDRDNSLFVVAPTSAGKTFIAFYAMEKVLKESDEGVLVYVAPTKALVNQIAAEVISRYKKNYRYAGKTVWAIHTRDYRMNNANECQILITVPDILQIMLMSPPNAKSWTPRVKRIIFDEVHSIGNADDGLVWEQLLLLAPCPIIALSATVGNPEEFGSWLASTQKSIGVKLTVVQHPYRYSDLRKFLYNPKKGMNSFEGMPQKVSRFNQLEMADYMRVVHPVAALANTKQGIPNDMSLEPKDCLQLYWAMSKCQTPECLLPKVLDFKEVFGTEGRVITKAEVVEWEENLKQVLHNWMKDAEPVFVEVAKLLAAEAAKKDVLDKEDDEKSSGAPAEGNGPLVVDLPPPSCTREYLAKTTLPLLQTLHSANALPAILFSYDRSMCEKICIMVCEQLETAEKSWRENSPKWQKIIKDWEKYKADRSSRGSKKAKIVLPPGSTKAEQMRENAEYDSSFWSSFDPSHPSPEFSFADFKKHAKSDLQIDIDNLIRWGIPEVLVHAFSRGIGVHHSGMNRKYRQAVEMLFRKGYLRVVIATGTLSLGINMPTRSSVFVGESVYLNSLNYRQASGRAGRRGFDNLGNVVFHAFSPAKVERIMSSKLPSLIGHFPISTSLVLRLFILLHNSNESDHAKHTINTLLTQGQLAIGGGEFKEQVLHHLRFSIEFLRRQKLLDSNGRPLNFAGLTSHLYYVENSSFALHVLLCNGYMTELCKNISKSPDSTCLELMLVLANLFGREQKLFPRHRSLPPLPAAAAELLANQNERTLRTYVTYVESFVKEHCNKPDNVLPFSGLECGGKRTTDEPNAKSRSSFVALSGHGDNFTSVNDLTSSVRRGVLIDGASVPHLQADASTVNGYLYYFYIHGDVKKLDQDHGIPAEAVWFVLKDFSLVLAAIDAGLTCFIKDGPGAYYDFKDEGDDIDGDIQEDDEDDKESVTTSTSTDDGSSGVSSEAADPGFKNVLKAVTILRKRFEEKFKKMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9I3</accession>
    <name>A0A2T7A9I3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_7043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9I3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="85" mass="9233" checksum="EDB16669D733DA0D" modified="2018-07-18" version="1">MPIALQCNTNSSSTKKCPASFSIPSAVSGPLPPTIFSKPPRYYSNDQGPPQNKVPKQAPRSSFRPSDPPHTVGRQSWSWHGSGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9K1</accession>
    <name>A0A2T7A9K1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1098183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9K1"/>
    <dbReference type="STRING" id="42251.A0A2T7A9K1"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35159" checksum="129B89160094F817" modified="2018-07-18" version="1">MSDRVETRVPLNINEGDLEAPESPLPRPITSCTTYSAIIAHCEFVKLANQIHSSFFTFRGLRPSRDLIRSLDERMLAWQKSLPAYFNADAEAPAWFAEPKAVIVWKGLNFRMLMHKCFLPLLKSPAVKAEAIEGIAPTKSGAGVCLFLAIQTIHSVHAFICSQTLRRGAAWYCTYFSFQAALVLVIAILTVDETPPPAIWTGNILMAEECLAATSRCLGDGASRYLEVLQRVMSIWGTRARPSAPSSPSPTSSFSVYTIGEGPSNTSLLADCANGLGFGELGPMPVDAAEVPDDYGLSSWMPTAQDFLESSIEGFVMGRADATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9I6</accession>
    <name>A0A2T6Z9I6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1098009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000764">
        <property type="protein sequence ID" value="PUU72139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9I6"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9I6"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="135"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="217" mass="24737" checksum="1713E48AA2D49E9C" modified="2018-07-18" version="1" fragment="single">ERSFPDPPKSYTEQQAAINMPVQDRTPWHNVHIYDASNPGMVLGGLLLNNGVTTANFYSMVEIVFVFDQDYTLRDESGITVERDDHPLQPGKYFIVTAGSITVSDETWLVRAAPVSTLPYPEEFRHAIHEWDRGCVMTGRGACGVAVGFFLGLETAYVFPKAYEHHWIKHNYGDWITLQPESRRSINSVQNGLLLWRDLRIHFENYMVSINPDVCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAH3</accession>
    <name>A0A2T6ZAH3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1117769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000534">
        <property type="protein sequence ID" value="PUU72446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAH3"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="502" mass="55700" checksum="57FABA130F25A795" modified="2018-07-18" version="1">MSEKSPPPPAKKPCLLPPEILSLVIQHLTPHDILSLSRTDRYHHTFTSTEAWRIYLQAHLPAAHAQILQEHRHRRRHHHRPQHQGPKINWARRAEEAALVSRNCSRAGFIATALKPAIYMYVPRGPRRGPDGGQVSALPWEPGTRGASGGRRQTVAYHPQIDAYGEFRGDRDVLAIGAGQDIMVSKSRGQHGNFWWGFEDREQRGGRDDVTGLHLLRPHEKVGNKDVEIALVGRANGRLEMLELDTRGRAGVTHRPKVVVRYHTDGRMVKGMNMTHEGNGEGVLVGAILNNSSLSIYNIQQPPSVGEPASIVREVSEAQFADERLWEVSFLDHTKIAVGKASTKPIVIHAITPSGLTQESIRGFSAKDCADMQSASVCAIKPLPGGSTGASANGDQGNHPLPLPLSLHHPHYLTYTQAPRPPHSSAYSLPILRPHRLPNSHLLPPPTLQPRLRNRRKPIRPAKPRALPRSWRWWEDGICWFTRKGLGAGFLGEGRGEEGRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAK7</accession>
    <name>A0A2T6ZAK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_660320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000517">
        <property type="protein sequence ID" value="PUU72503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAK7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAK7"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12159" checksum="46259CBE1826C44C" modified="2018-07-18" version="1">MERISAGVTENVGGVDAGRAGDVCALGVNLSGALSGVERKHFLVLDRVDRTKEGSSVLLAALGRLGEMQIPSLTVIFILSVPKPRLLSSAEPPHIHFAPYVRTGRHKSRYPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAU9</accession>
    <name>A0A2T6ZAU9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1137127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000495">
        <property type="protein sequence ID" value="PUU72621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAU9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAU9"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015607830" description="Kelch repeat protein" evidence="5">
        <location>
            <begin position="24"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="517"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="63207" checksum="6D05DB6C293C5DBE" modified="2018-07-18" version="1">MPLFRCSVWLLGALLSFTSVVRSDGPNPTDDFCSLSAQMMAQKDDMLYIAGGWMLYPSPYTNYNGPNTVLRSLNVSKSFQTSLDSANYVRTEDVPGTVPGVQDAAFFPTESGFDLTFGKWWPYNSTLYGTRDPPIESKKWQYDIASQQWTNTNITLKNWFQTNPQMRITSGMTVWVPSLKQGFLFGGLFASENGTSLKVTALEEHNGLITYDQATNTWTNATTPLGGIAEGGLVHITTATDEVLIQLGGRSDWATRLRPFSEINIYSTSKSKWYTQHLAPDATVPSPRFTFCTALKSASDGSSYQIYIMGGLEAGSSADARGGPTTTSIWVLSIPSFEWTQLPFKATNTAADPKGRIAPSCQAIGEHYIFYYGGRNVPSYYNTPTCDKKADAAFLFDLNTLTWTDQFTPNEGTYEIPQNVIGLIGGDKNGGSTKKAPVKGWSDPDLETIMTLKTTTAGNTGTGGGTRSNNGTSSTSGSSTSSNPSKTNVGAIAGGAVAGVAAVALGLLGAMMLRRHRQKKKGPQLPPNPMKLPLTDAGNLEEGTSSAPLELMDHNRLSGGGVYTAELPAGEVAREIYTRPENRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC13</accession>
    <name>A0A2T6ZC13_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1096023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC13"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC13"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24449" checksum="A5F50921DBD9F967" modified="2018-07-18" version="1">MTLRALILGSGSNVGASITKKLQSEGYTVATLSRSPPSTSSAPSNHHHITADLATSTALKSHIASAATALGGFPNVIVYNAWSATFPQNADNWLADISPEAISKELAVNTVSLYAAAQAAVEGWEGLGKDDGAPRALIYTGNPLPWINVPTFVSLGMGKSASATLVESLAATYGAGGKRFYFTMQVDEKTGGIYNGIDGPIVAQVYWDLIQRKEQGGWKISFDKKLKLWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC43</accession>
    <name>A0A2T6ZC43_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1197167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000418">
        <property type="protein sequence ID" value="PUU73065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC43"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC43"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="258"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="539"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU73065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="759" mass="83564" checksum="F2140F8B8F0FE734" modified="2018-07-18" version="1">MISHGVEISIAGGVDEMSPSEEFIVTNFVAVSPRDFPAEQYVICDGRYILTVRPFDTIEPGYAGFSSAHRDWAQWSLTDCITIAPFDPFAHGRAPYLGSLDLEVGFAARKISDESYDQDDLTKLFIRSFQNQIFAPGQRTIMDIRNIKVLIVVKTVQIAKSPDKNSALPSDAPTTANPSDYGILTPHTYITFYKDAKSPIKIKGSNKRPAANAIIQPNFKFEDMGIGGLDTEFSQIFRRAFASRIFPPGLVGKLGIQHVKGILLFGPPGTGKTLIARQIGKMLNAREPKIVNGPEILNKYVGQSEENIRKLFADAEKEYKEKAEESGLHIIIFDELDAICKQRGSKNDGTGVGDSVVNQLLSKLDAVDQLNNVLIIGMTNPMDMIDEALLRPGRLEVHMEISLPDEFGRRQILKIHTNKMRENNVIDPDVDIQELAAKTKNFSGAEIGGLVKSASSFAFNRHVKVGTVAGISEDIENMKVNRQDFLNALEEVRPAFGVSEEELEQAVQGGIICYSQNINSILAEGRLFVEQVRKSERTPLVSVLMHGPPGSGKTALAASIAKASEFPFIKLVSPEAMVGFNEMSKVSYLSKVFMDAYKSPLNVVIVDNVERILEFVPIGPRFSNPVLQTLLVLLRKQPPQGRRLLIIATTTERSVLAQMDLLNAFDAEIAVPNVANHNELGHVLRELQAFNSDGERQQVLHDLYSTTRTKQLNVGIKKILMGVETARQDEDMAGRFVSVISKAVGENGVGLQGGEPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCB8</accession>
    <name>A0A2T6ZCB8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1095769</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="NESQ01000412">
        <property type="protein sequence ID" value="PUU73109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCB8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCB8"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU73109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="500" mass="57212" checksum="CE1B17E53BB572E9" modified="2018-07-18" version="1">MGGSQSEDSFEFVDTPPASIPQPASDSCGVRTTDYPSIANAPLPAEGSGNDSWSNTLMFGLLLGVPYYLKYKVGGGFKTFIFFALVVDLPILVGFWVVMSTYSPRKNEKVKLPGKGVEHYLQFHKQEDAVKYKGSTKIPMEVFYEMYFEGDVSFKGDCLEILERRHDWATFQFTKGLFKHFLFGMIPELLVHSRSQDEEQVRDHYDRGDDFYGWFLGPRMIYTSGVISDIHKEESLEQLQDNKLKVVCEKIDLKDGDRMLDLGCGWGTLARFASRNYGAHVTGITLGRNQTAWGNSGLRRDGIEESQSNILCMDYRDTPIPTGRYNKITCLEMAEHVGVRHFGAFLSQVYNMLEDDGIFFLQIAGLRKSWQFEDLIWGLFMNKYIFPGADASTPLGWFVDKLEGAGFEIKSIDTIGVHYSATLWRWYRNWMANREKVEAKYGSRWFRIWEFFLAYSSIISRQGSATCYQIVLHKNLNAFHRVEGIRTQYQLSGALSVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCC6</accession>
    <name>A0A2T6ZCC6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA synthetases class I (C) catalytic domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_887577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000409">
        <property type="protein sequence ID" value="PUU73152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCC6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCC6"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="4">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8762" checksum="836D54FAD12863DA" modified="2018-07-18" version="1" fragment="single">LRIHNSLIKERNLFVPIDPSSGGITWYCCGPTVYDAGHLGHARNYVTTHALRRMLRDYLKFEVQFVQNVTDVDDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCJ7</accession>
    <name>A0A2T6ZCJ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1135599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000399">
        <property type="protein sequence ID" value="PUU73221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCJ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCJ7"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF77">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="663" mass="73550" checksum="AC76956B93B6B466" modified="2018-07-18" version="1">MNDDPKSSLRSCTSCRARKIRCDKVKPSCHACAKNRLSCEYPTVARRAAPRPRRDVVLMQRLVKLEAVIGELSGVGSGAAVGGLGGAGSESDTGGGSPETHGSGDTEKGLELEAGLGRLLVSEGKSRYIGPKFWASLSEEVADLKSLLDEPPSSAVTSPTSPGAAFDLPSSFLFRSATEDLSVFYPTSAESSQLYGIYLVSVDPVIRILHKPTFESKLMKLQEHGPESAALHADRGFEALVFSVYYAAVNSLHSDKAPQMFGIEKPSLLNRYRVAVEHALANAGFLQSEELTTLQALVMFIASSRAADDTRTPWVLVGVAIRIAQSMGLHRDGPIFGINPLETEIRRRLWYEICLLDLRTAEEHGSDPGISTQSYDTKLPLNIEDTDILPNSAYPIIPRKGFTEMTFSLIRFEVLDCFRIVVRSTPGAVKVKGVEQLTLEEKEKMLDELAMKLAVEYQVGLDLTVPIQGITDMVIRLMVGRALLCLYHPLRHFKDGSLLSEEKKDKLFRTAVEALECSAFLVRDPNAARYQQWNWLFQKHNQAHAASFVLSELAVRPPFGTDDMVERAWAAIDLLLDTEPEQWIQEHPLMGEGVWKPLAKLKDRALARRRRAMQDMGMAQGQGPSASLLTGESYMFEGIDIEDAPIDWREWDEMFQYIKMDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDC4</accession>
    <name>A0A2T6ZDC4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I restriction enzyme R protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1004379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000373">
        <property type="protein sequence ID" value="PUU73483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDC4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDC4"/>
    <dbReference type="OrthoDB" id="5362978at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24245" checksum="166F1E050B66C54D" modified="2018-07-18" version="1">MPWPPKIIKSFEIAESTGVKDESRFYGPYNTLLTYLFPFEEDFQVAPQYKRPRQSRSVDFTTIFIVSHGEHPVFFVEIKASSHIEQISTRADADKQMRERINSMFDSVKIDTLYGISALGTRLCVYKTQRESGDIEPQGIADNLLRVTDTAPLERWNLNLLDGEGEKRVREIVAHIKETSVSCHIVQNWKDFTNIFRRFRVGGIREGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDG4</accession>
    <name>A0A2T6ZDG4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1135038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000370">
        <property type="protein sequence ID" value="PUU73530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDG4"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="34332" checksum="BD73CE76CE6FAA4B" modified="2018-07-18" version="1">MKLSHQDFVEFKRILHGDGEEEDDGFPKYSYYASSSSLLTERPAGALHEKIVSIISDGFVYSRGRLPRNIATKISVVGNQTMKRFEGTHRGSRKAADVAVQVTNDNGNREVKFVAEVGVAETYDKLTDDARLWLEGTQTVSLVMLVKLEESPVYQCPIRKLSEKELKRMNFPATNQIDGSNFLLASQYGPAIFNGYTWVGKVSGYFEFWGIDPTTKLAKCITSTNNISEMEKNPESGLYLSELIDIDEEHDEEIYFDWVNFLETLKETIKEMAVDRYVEALDDAEERANGVDKDYQQPSQASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDR7</accession>
    <name>A0A2T6ZDR7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000361">
        <property type="protein sequence ID" value="PUU73635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDR7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015742550" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9473" checksum="F5615130F3F72432" modified="2018-07-18" version="1">MNLVRFVLPWFVFFTIPAFPIHSGLCIIRSNDSGVSIGLCIAWSPPKPPEKSDSRAAGSLPVPYCHTGWFCFRGPLPRNTSNLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE97</accession>
    <name>A0A2T6ZE97_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1094433</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE97"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE97"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="81"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="24191" checksum="CF28E41E65D4267A" modified="2018-07-18" version="1">MAPKVLFVLTSQKVLGETGRPTGWFLPEFAHPYHLLAPHVTIDVASPAGGEAPLDPNSVEMFKTDDIAVKFLSEKQELWKNTIKLENVNTEDYDGIFFVGGHGPMFDIARAPIVVSLIKSLADTNKLVAAVCHGSAALLDVKLSDGKLLVDGEPVTGFSNAEEDAMGLSGAMPFMLETDLVKDGAKYEKADQPWGAKVCIGRGGKLVTGQNPASGLGVGEKMKVALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEA7</accession>
    <name>A0A2T6ZEA7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1068688</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEA7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEA7"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF196">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE SWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="538"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="946" mass="103625" checksum="E1AECE0BB227BB15" modified="2018-07-18" version="1">MVASYSPHRHQGETATLFSAPHTTSPSRHHMLRSPTSCSSPFAIPIPSSVKTRSSTRRLTPLKSRGSSTAPVSPVKFPLSLTTTSHMNSSGMTLRSGSSSPRASPREKIALQRQARAGLGMENGAQSPPSTGSPLKRSDGIMNLDQASRGSPVAKRRSQFGLYSSGHKQQHTFGSPSFGQSPTPVHHNTTPKRHNTIKKSAGHGFSIEKPSFARSRPQARQHDFVTPSDPASKIRRVTSVDNFHSLRRGSLSNGSSLPSASIHPHHGAGTALQSTSHHPHPLSQNTFSSQSPGLELEKDSSEGSNEWRTPQNFRFARPNPAAFHSTGFVPKRGRLMHADKDHGPQPDTPCKKPNNAFGSSAFQSGMGGGRVSMTDFANTSTPFGNNGGGVKLGFGTLDRKASTLSTDDESDLGQSQSSTDYDLPPTPTKKVYSNIGGIFNSAKRARTEQSSDDLRVRYSQRFEPQTPKDNIQPPDPSSLSISGRANHAHRMSLPATPARDFFSTHFDFSSTTKPRPPRTVQSLDGRSVEVTDSFLSRFSEIKHIGSGEFSEVYQVTEGRPRRNAFIASLNPSTPHQLATPKHSSPFGSSPVGNSEPLLKTYAVKKSKSRCFGAREKGRRQEEVQILKSLGRSEHVLEFVDSWDEDGYLYIQTEFCDNGSLDKFLEQHGNKGRLDEFRVWKVLLELCLGLQHIHDLGFIHLDLKPANVLITFDGALKISDFGMATRWPASRELEREGDREYIAPEVLESHRYDKPVDIFALGLTMIEAAGNEALPPNGPEWQSLRSGDLSVAPILSTSSSGELVVRDEDGNPISTVVLSSPSSSSLDSQISDSSQPRHISRRALRTRTDPALLHKPRAGDLVNPPDFMLEGGLEELVTWMISANPDHRPTVSQLLETDSVRWVESRRRSPATVFEGLWGPDVSPARIAEEEDDVMVWEKPEDSSPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEB2</accession>
    <name>A0A2T6ZEB2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000340">
        <property type="protein sequence ID" value="PUU73838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEB2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEB2"/>
    <dbReference type="OrthoDB" id="5405293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="226" mass="25833" checksum="C5E94E031B112409" modified="2018-07-18" version="1">MADESLRLLTWRELTPSQRWPWLATPLRLLEKIPGFNIVVLLIAGKMKHSQQEEEDLDNEQRELMHHIEAIEQNIREIQQQLLDHLPSLAVSYPQHSPGTWHQFQQIIMLLHDIQGHGAGNASGTRPALSPEDRKQFQEENLLHDKNNLARLINSKVTVSTMPLEPLYGADGKPIPNFPETGADIKKLKGRAINNLLLALGLSIDGALEDRRKRFMKYIGFTMLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEH1</accession>
    <name>A0A2T6ZEH1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lysozyme-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1134197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000335">
        <property type="protein sequence ID" value="PUU73890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEH1"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00737">
        <property type="entry name" value="lyz_endolysin_autolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04110">
        <property type="entry name" value="ENDOLYSIN_T4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051018">
        <property type="entry name" value="Bacteriophage_GH24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033907">
        <property type="entry name" value="Endolysin_autolysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034690">
        <property type="entry name" value="Endolysin_T4_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002196">
        <property type="entry name" value="Glyco_hydro_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023347">
        <property type="entry name" value="Lysozyme_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38107:SF3">
        <property type="entry name" value="LYSOZYME RRRD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00959">
        <property type="entry name" value="Phage_lysozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015638001" evidence="8">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="35918" checksum="29229B597675AF8D" modified="2018-07-18" version="1">MKSISFAGLFVSTLVVSASAFPHFNSIFGRGGGDDCYTAYGQGTCGSPKDCKGITVGKKYCGGSGDYQSQCCVELVCNVPAGKGWCRDVKDGDYPGGSFQYSEYGNSEWPCIGGDIQCWVPGSNNSTSTSNPTSTSTSTKTPTKLPTKTPTKTPTSTSTSIPISIPTSTPISAPAPISASTSTSDSTGGNAVINAAGVAMLKELEGFRGDIYKDQVGVDTIGYGHNCAAAPGSCEAMKQPISPSDAENLLMKDLEQFEKCVCSLPNSEGLNSNQFSALVSFAFNTGCFGTSDYFKDLMNKKDYSGICSALPNTNTANGAPTSRREAEAKLCSTPMKQTCGCKGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEM8</accession>
    <name>A0A2T6ZEM8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1134134</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000332">
        <property type="protein sequence ID" value="PUU73945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEM8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEM8"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="150"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="456"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="499" mass="55289" checksum="9CB109C81F62859E" modified="2018-07-18" version="1">MSYSDRPTTIKGSTINGAFSNNVNSFNNYGGGGVRFYTDDGFTGYADDGGPPYAPQGHPTARRVRTEPITPNPTQSRNSTENQPAGRHVRTESMAPYPTQSRNLGVNYDAGNSPFFTGGAIFGEPRRGTPSPAPTEADVYGAPVREPPAWKLNYEIGSGTFGTVFLEKVQTREMGSPELWAVKRIPKAVPNFPARRYQEEAKNLHALSNYEWFVKFNSSYEDDHCVYIAMEYIPIGDMMKTFEHGYRWNESDTRVVIEQLLRGLVVMHGAGITHRDLKPENIFLYLPEDRTQTLRVKIGDFGTSKRIPLTSSSTYLRTNTGTQGYIAPEVEDTSNPKTNKVDIWSLGCIMYRMLTGSLLFNNHREIWKYAETASSPPPAVKDKGFSIPSQDFLRDVLQPNPENRPSAEGCLMMPWITNKAYGLEYAIGSDLYKRLAKIQCSAPDIDTFSDIATHRADKAPARSSTAGARLGSDSMASTPRSSWTSNTGSSITLGPHIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEQ0</accession>
    <name>A0A2T6ZEQ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000331">
        <property type="protein sequence ID" value="PUU73965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEQ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEQ0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="27261" checksum="221D99B0D3B0EE1A" modified="2018-07-18" version="1">MLTFINRLFVSRVGGKPFHSSITAVRLAHTGSSPYTIFPTTRNITQPLSFGVDRHANLIRKGPQEENRRDLCSYTHNFVIDSEEDKVDTTDIKREIMRLIAAKTGIPHLSKVPMAEAKKMVRKCPGFIYGSKKRTIVPSPVSYGAEARWIYFLVLSTFRSTYLSTEASEALGLKQDGESTITIAGRPYPVCRAPQDSPISNINVLGTGFFMMNGVKKVENYATGRVQLFFSELDNQDAVFELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEX5</accession>
    <name>A0A2T6ZEX5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1196510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000326">
        <property type="protein sequence ID" value="PUU74033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEX5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="19852" checksum="E815402D2764497F" modified="2018-07-18" version="1">MDSNVQIAHRQLIDSVFVSDSQEANERAIVALAHVHSFEGIAIDQKSQHAQYNVLSSAAIHLKPLVIPNDARHESLKIPRMAAILTVFHMGLFRLHESRLSVIADIGNEAWGRSIGYNTCPGQPRFAYYDTTPTTITRLPTISSPHDHLTKIQNQEFRARAKGLPIARKDNPAVKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFA1</accession>
    <name>A0A2T6ZFA1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1093563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000320">
        <property type="protein sequence ID" value="PUU74165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFA1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFA1"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12633" checksum="0680E07E4FD30A97" modified="2018-07-18" version="1">MLSQTHFLRLRLHLRLRPLTIPPTQRYSTAQKEFEALQKAARDSFFKTSTTSSSATPAVADVEEDMLHPDARRGAKPEFEGDVNPKTGERGGPKNDPLRYGDWAFNGRVSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFM1</accession>
    <name>A0A2T6ZFM1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1093191</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000308">
        <property type="protein sequence ID" value="PUU74300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFM1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFM1"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="580"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="234"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="847"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="847"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU74300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="892" mass="98764" checksum="3C8A4F824FB8A962" modified="2018-07-18" version="1">MKVQCTVVTTPTSDTPGTCILLHFDSKRYLFGHIGEGAQRAFVERTIRLTKISDIFLSGRTEWQNTGGLVGLILTMGDQDAAKNSDSLGNPQGGPKKRKPLERKGVTVHGGENLLHTLATTRPFVFRRAMNLRLREVPVVESADGRKEQAIGAPYFRDENLIVHAMHIYPEEDLKNSTEEIEAGSPSAVGKVKAGATRKRSFDDFASLEKQRESILRGVVEQMFCSDWSMDTMIEEGDPLDAPGPSTDTLVESLPTSSSGPDMSRTRSTSPSKRSKPIPERDPNLSTTLPPLGKTRAPWPASTVHSLPRSRPTRIALSYIVTLHPQRGKFLPVKARELGVVPGPDFSRLTAGEAITTPNGNIVQPADVMEPVRPGTGVAVCDLPDTGYIKDFLAREEWKDTEKVRTEIGCFFWILGSGVSADERLQSFMKQMGHSKHIVSALDVCPNAITFKGGAKSSTKLNLLDEKFFPLPYFSDQVPSQVDEFMEPAKPRMIFRIEPRWEFDTKAVELPFSREAILQEAEPAYVELARIAREGNIKNPGDDSPWKDVEVITLGTGSALPSKYRNVSATLVKVPGAGSILLDAGENTLGQLRRLYDPTELKAALRDLRGLYISHLHADHHLGSAAVLKAWYNEVYSPANSETNQLMNVVAPWKFLVWLREYADVEEFGFSKIRFISCEDLLRKNLDNPNHLTAHLPEVLDSLSLTSIQTSRAVHCLSSFTTSWTWSNGFKIAYSGDTRPTKGFVEIGRDSTVLLHEATFDDELLPEAIAKKHSTTSEAINAGKEMGAKNIILTHFSQRYPKLPILSAAEENGPEVLVAFDLCRVRLGDVKRFGTFIPALKELYEEADEEKIEEEEEVEEEPVVEEKKGKVGKAGGYKPGGNKSEKKSDKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFS2</accession>
    <name>A0A2T6ZFS2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1196312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000306">
        <property type="protein sequence ID" value="PUU74337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFS2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFS2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="581" mass="65718" checksum="03FBC0D4B8595131" modified="2018-07-18" version="1">MGTLLILVVCFGAAIAAYTISSIIHLLYNIREVRKSGLPYIILPWHEMNLFHVLTCGFNRDLWQYLPQWTYFKIFWRDWCHHTKFELFEKYGDVICAVSPGGVTIYVGSVEVARQMYERRNDFPKATKVYEYVRFYGDNVLTLEGAEWRRHSRYTHPPFNEGVHKVVWDEGVKQARAAVNVWSRQNSCLNIGRDLRTISMNVLSLSNFGVAMPFDYESETTEHFGWRNIPPGHKMSYGSTVNHVLDNIIPLAIAPKWLLRNGPESLKRIGQSYDELGIYLKELTQDDGKSGASDGGNLLRALVKASAGDGPGKGSRLTDAEVFGNAFIFAVAGLETTTGTLHYAIMYLALNPDVQDWLYTDLQEALKDEDQDPSKWEYGKVYPKMASVLCVIHETLRLNAPHMHIPKWTAGKYQPVNWKGKQCLIPPGASAYITTTALHYNPSLWGDTVNGFHPQKWDLRSSSEGWVRTDPKTGVKTPITPSETPRIGTQSAPYCYLRTPVKGAFAPFSDGWRACVGKNFALVEMAAVLAVLFRDCSVRIKRQEGETQGMADNRGKSAISNSKSYLTVMIRHDVELEWIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG31</accession>
    <name>A0A2T6ZG31_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1056270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000300">
        <property type="protein sequence ID" value="PUU74432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG31"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG31"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="5">
        <location>
            <begin position="213"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="593" mass="64412" checksum="1424A8C2C67D2467" modified="2018-07-18" version="1">MSQSSKSSKISPDRFIPSRANIQSFRMSAPAHLLSSNERLLRRSVSSSSADRSISPNSLSNSSNNGNAGGSPINYRPSNLNRRISAGAVGVFGIGVGAAPRREEPRPRGREVTINVFGDKSSPESDMERHERRLSAALGVDRSAKVLSFARENEPTRDGHGRKGGVMGAPGSETVSDMLWEDVLEAEGRDSPQVSPSRKCPRRVVPTTPFRVLDAPGLRDDYYCSLIAYSPATHSLAVGLNTDVYSWTETSGARPFETWSNSHVTALAFSCFQGKRNILAIGRIDGSLSLWNPAEPTPRLERTHDTGIACLAWKPIVSYRPDSGLRSSSGFPFSDGRFQSSSTMAETEELLIVVHSQQICGLAWSGDGEQFATGGNDNVTCLFSTADVICNRSGGVRSHEATTLEGGEKHRWAHGAAVKAIAFCPWQKSLLATGGGSNDRCIHFFHTFSGATLATINVSAQVTSLLWSNSHREIAATLGYANPEHPIRIAVFSWPECRQVVQVPWQEDMRALYAVAYPGGPNDNFAPRSREINRQANRVEGCIVVAASDETIRFHEVWSETRRGVLGWRGVLGGSDILEGLEGIEKDGAETIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGI1</accession>
    <name>A0A2T6ZGI1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin fusion degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_919887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000289">
        <property type="protein sequence ID" value="PUU74597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGI1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGI1"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="23"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="123"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="38019" checksum="C666CD18F69534EF" modified="2018-07-18" version="1" fragment="single">QFGGNFYDDDDMVPGYHPRNRRFDEFLRCYPVVMMPGAERAELNYGGKVIMPPSALDKLSRLHIAYPMLFELRNGAKDKVTHAGVLEFIADEGRVYLPHWMMQTLHLEPGELLQIKSTDLPAGTFIKLQPQSVAFITSITDPKAVLENALRTFSALTVGDVFSFFYNDEVFEIAVLEVKPETKMNAITTIETDISVDFAPPVGYVEPSRAPQSSRPGSVVGGRHVTPLGETGSMARSINYAAIAPSSAASASATSGAKQSFFTGGGGQKLKGSKTSTPRDKPSTPVAGVSSNPPPPAIPAPTVRRGTGPQPLRLPPGQLFFGYEIKPVKKKDGDQGEKKESMFSGSGQTLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGY8</accession>
    <name>A0A2T6ZGY8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1110522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000280">
        <property type="protein sequence ID" value="PUU74674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGY8"/>
    <dbReference type="OrthoDB" id="5305647at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15340" checksum="349334634EA53679" modified="2018-07-18" version="1" fragment="single">MDHVEGSYRNVAAATVKPVIGGPRTWLAPHEFSLISFDNSGYRQPLPPALGDLPLHLDHDGYFSVNGSLDLTVSPPQTSLAPVSHCNESTFRPLITDITGFSGENSHTTPNPHSGYLDADTISKGTRARSERRSYHCREPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH86</accession>
    <name>A0A2T6ZH86_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1132440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000268">
        <property type="protein sequence ID" value="PUU74851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH86"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="79" mass="8319" checksum="608D5F06DD022643" modified="2018-07-18" version="1">MSFTLVLPVISAAVIHVELPGTLWCVPAYSHIVTSETPFAAPVSLGGYASRVQLFPDYIPGTSANGSMEADPIVPPSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHR6</accession>
    <name>A0A2T6ZHR6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_996604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000256">
        <property type="protein sequence ID" value="PUU75019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHR6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHR6"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="222" mass="25270" checksum="B7CC318BB51CB31B" modified="2018-07-18" version="1">MSGIIEWAFGRRQTPAERLRRHQRALEKAQRELDRERIKLEQQEKKLIADIKRSAKNGQMGACKIQAKDLVRTRRYIQKFYQMKTQLQAVSLRIQTVRSNEQMMVSMKGATTLLGSMNRSMNLPALQRIAMEFEKENDIMDQRQEVMDDAIDDVTGLDDEVESDEVVNQVLDEIGVDMSQLLGETPTGLGNMNATPEGKVAQAVGADSMDDDLQARLDSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIF1</accession>
    <name>A0A2T6ZIF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1090809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000241">
        <property type="protein sequence ID" value="PUU75236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIF1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="13401" checksum="92493B2E2F8C016C" modified="2018-07-18" version="1">MTGSPPTAPNTMATSETGIETPAQRQPEGRYRPPDFEEVKHDPPYWLMVVVMCGCALVLRAVFEEKLHPLIDLYVEGLTEWRLALSILCYAGYLILLVISLILCMLTACGLVEGLWFLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIL2</accession>
    <name>A0A2T6ZIL2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIL2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIL2"/>
    <dbReference type="OrthoDB" id="10461773at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="20252" checksum="6CB5F0518BA2B2A0" modified="2018-07-18" version="1">MSIAFALKLVNSTRTRTTSLNNRRDLNLKTSMPKGKSLSAATRGAIMALRTCAHMPFHQIAGILDLPFETIWFTYQRTTELALGPDIKDLLNIIEMGDKKRPEPAIPQRFPAGSEVSERRGNLATKDEEYRLRTFPQIAREARVHAADSTIYKIIHRYHQLYRYAPRRKPVLDCDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIL5</accession>
    <name>A0A2T6ZIL5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1103000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIL5"/>
    <dbReference type="OrthoDB" id="5390017at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="34886" checksum="AEC6A796DE656C02" modified="2018-07-18" version="1">MGLQYDSPLLVSSPPRITQPILQHPVPHRTLARNFTAFANKSTTNTLLPLVPCPESLFLQTPALPMSYQPPQPPPPQPSPSPSLFAAALSKKRSPQAAFADDTPPSSRPPSRSHTQKRLRAKRAAERPGWVSSKDDSIGLDARVEAVVVDMLWPGVESLDCGRRVGDLRRSGGFTVLCFLGCTIEHLHGLGQVASLLGNLNADVFGVSLSAPPPYTSSLPIIHDRTRALTLSLGLLHPLGGGRQALDAIVILDRDSRQRVVLPVGWGPRPVPGQCASDEESNSINSIVGRCVKGVEWLCNEALDDTVEDAEMGMMDNEIVMAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJX7</accession>
    <name>A0A2T6ZJX7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CP2 transcription factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_993132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJX7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJX7"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="7">
        <location>
            <begin position="46"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="578" mass="63410" checksum="004F1011735BEDDF" modified="2018-07-18" version="1">MDLGDSGGEILPGPGPLEGSVMGPTQLLALEGKQYDHELGPVASSERFRFHVVLNAPTAMIKHPDEIPVTYLNKGQAYAISILDTTPPPSTGPMRYRTYIRISFHDETQRSRPASCWQLWKEGRGTNEAHQRGGKLQAVEYVEASSQPDDDKKKGRVDIETASFDSFAVIWSPSPSGSPETSVSVRFNFLSTDFSHSKGVKGIPVRLCAKTEILSSGSPQSPPEQSEICFCKVKLFRDHGAERKLANDILHVKKTIEKLKQQANQVEGTSMKVFGKKSKKDEDSGKPGKALKHKRTWSMSSASSVGGGRTQEEDTNAKLASMQDMFTSTRAVSVLYLRGSEIDDPDLHPVYLPGEMPELSEDVWARRRSSVATTNTTTSSFVSPTSSSASQSSQHGDAFNSLERRDWEREYQPLPPPQQSHHPDVSDAPVRVKSDTGMLSGWIEAIGIDSSYNPPPERPVKPVMSIYILPTPTGSPPQANQYYRAIYLQARTSSCLAASIASKCGIDPSAVLRTVHVNPRGLTILVDDEFVGEMQEGQDMKVQATEIREESPFASPPQESEGKTGAVAKSGWELRLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK07</accession>
    <name>A0A2T6ZK07_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_993111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK07"/>
    <dbReference type="OrthoDB" id="5401962at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="273" mass="31005" checksum="0FE9479BA541DA75" modified="2018-07-18" version="1">MVKKAYPQDCIVGGPGQRPIILVTHDESTFSSNDGRRQAWIGPARHFLRPKGRGQGIMVSDFLLPWSRLSTESLSEEERTNSDTQLPLYATKYLEYGKTEGYWDGKDLVAHVLEVALPMLRKIYPGYQFLFLFDNSSNHGTYADNALRVQSMSLKSGGLSQKLLRRGYMNGDPAQVQEMTYQAIDSHTGTETTLAKGMKVVLQERGLWKDGLSMHCPKNLCCCAAEILSREEDFLAQKGMLQEEIERSGHLILFLPKFHCELNWIEYYWGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKT6</accession>
    <name>A0A2T6ZKT6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000204">
        <property type="protein sequence ID" value="PUU76066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKT6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="268" mass="31187" checksum="67DADA310D16AE21" modified="2018-07-18" version="1">MQSRFFFTRHGPFKYPAMFAARFHTATVVQAGYRKKDGPHKPHTAYPTASKNQYKLPPETATLLTKLANANNDAQHSRILEYLKFQARITQAENEKFREHLAIREREQQMEMKRLIHDNRELYAAFRRERNERGRWDSNFNLRGAVDSDTNSSLPKQKKSLNGPSTKRRSRGGGIQANLNQIMELSEFKETLSKVLKDRGLRGDDVWHCLNILYPTLSKYAHGNDGDIVLRGIYHPDNERAGLVALMRVQGRWKEPCSWREEPEEVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL37</accession>
    <name>A0A2T6ZL37_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000200">
        <property type="protein sequence ID" value="PUU76134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL37"/>
    <dbReference type="OrthoDB" id="5367675at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="236" mass="26251" checksum="F24FAA992D24A9BA" modified="2018-07-18" version="1">MASVDDYSSSAERKEEDCEESDDDEPIWDSAVNMYVAANTEEEEGSTQEEPQISGEEMGDLESNHEGDNLDVGHIEGLAGHLEEICSKEAQLGNTDSFPIIRVIQRKGRPDSNAAVVVTTRKRTGAAPKALCDYKLQQRLSSQLKLSAKMKQEAEAAQENGQFIFTHIFGSNCNTIEATLEDTKGLGYGFEQIDTDDKGFYVALDKKSERIFVMFGAGLKLIYRDNIREYVEKAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL65</accession>
    <name>A0A2T6ZL65_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_991142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000195">
        <property type="protein sequence ID" value="PUU76229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL65"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL65"/>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="567"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="681" mass="76894" checksum="9EADD7CB72A08B02" modified="2018-07-18" version="1">MINVDPSKVVKRPVTRGRSEFISQVLRRFKCRGQVADTEITVSMSPSDPDFPYDIKQLVFKLLVPKSYPESPDALPSIRVINEDIPVGFRVNIERGFDGLATRRGDSTLLDLLNSLDRCLEGFLATGKVETLKIVPNTSQSTLLQSSQSQMPLTTIQPPRPSLPLMTLPANSPTPEEASTAQARRERETRRLEARMRESSIFRKSEDGTRYTVPIEPKKRYQLPVPLQKVTSVVLIVPLSYDINRPWLEFSGIPEDVVQRVNNGFAKQIQKNPKFSLMENINALCSNLHIMATEEESLENHPEEGVEETTQSPEDPAAADPTARAVPSKEKPTGIVLDDKAHVQVVPRPPDWNIPEDGESDDYEGSEYDSDDYISDDPQPNHGEDAGNRVDQKAIERGTAMSLPGIDMPGIQLLEVAKLNVTVKCSKCKKELEVNDLKPTMPGKTSRPKLSQCEKCSQVLGIGFRQEFVHMNSNRLGFFDLAGCAIVEILPSDFIPQCASCSTSLPPPGIKGLVPGQRQSTNCRECHAKLSILIPEIKLLRITFEDEASQVPNKKSTERERYTIGHELPFQGRCAHYKKSTRWFRFSCCNKACHHLQLVFPCDKCHDKQVEPFHHWEHANRMICGTCSREQQYRPEECGYCKHAFIKRYTGYWEGGTGTRDKRLLRRNDPRKHKRVNKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLH4</accession>
    <name>A0A2T6ZLH4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1194804</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLH4"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="13383" checksum="7DB2015174CFF350" modified="2018-07-18" version="1">MAAQAPAQAAKVLNPALNPRTVHFWAPVLKWGLVIAGASDFYRPVESLSITQNVALFCTGTIWTRWCLIIQPKNIPLAAVNFFLAGVGSVQLGRIGLHYQNLKKQEKEHPVMSEISKKATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLM8</accession>
    <name>A0A2T6ZLM8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1194770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLM8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLM8"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000006">
        <property type="entry name" value="non-canonical poly(A) RNA polymerase PAPD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="9">
        <location>
            <begin position="386"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="8">
        <location>
            <begin position="587"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="798" mass="89322" checksum="65412F3B429E2723" modified="2018-07-18" version="1">MGDRDRDRRVDDIRRFAGRGDPNNLNHEFTYQHQRQMPIETDSYRPSNRSQDDNRGSSRHPNGSKGSKIGKRQKAKQQPKPPKWIPVPAHERPILSFNARDKTPDLLPGMITGGEFLSALDGSSDDVGENMCDAAGSGDEAEMDMSDDENSALADTKVISAAEGAVGGEKKPDVISLIRSFKAKASPGKPKNPVEDNDDFISLSFGDEPIHSDQSDGDSSHKRRKVNGKDNRDEPSFSHRYNHFGPPKDTGPPGLPPRPLTYRKPTPPPQLRDLDLQPRNRSTQQSKSGGPSSLPNTAHSKHTFSNASGNAAMQNKGHDRQLDIPKNRKRSYSDMSRGKSYIDGNITYEYTATPRSDPFPWTKMGSDHSRSLKNEESNSFCATYRLHNEILDFIAYIQPRAYEHAVRRHLVHRVRVIVTKLWPDTDLRVFGSFAAELYLPTSDIDLVVISTSFAKLGMPRYSERNALYRLKQALLHSNITKPGSLVVIANAKVPIIKFVDRETEIHIDISFENSSGLVANETFIKWKTQYPAMPILLTVIKQFLAMRGLNEVYLGGLGSFSVTCLIVSMLQMHPGVVSGGMDPRKHLGIMLLEFLELYGKNFNTETLGICVDSRKPSYFRKNDVFPIIQRGATPPQTDLLCIQDPNNTENDISRSSYHIKMILTLWAEALDDLVGQMKKFETLQFVDRQGRSLLGVILGGNYGKIEEQRCLMRKAYVDRIGPLEDAQMEERQWGETALLVKQTRSPVQQATESRPANGPAPNKETSRSNNSGGSSYPQKSKQLFYGKGEQDEPIVIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLN5</accession>
    <name>A0A2T6ZLN5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sas10/Utp3/C1D family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_256055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLN5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLN5"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="40749" checksum="DA05C77B82D7A137" modified="2018-07-18" version="1">MSPPPGLLETLTTLTTSLTTASTSLQSAEFPTLTPPENGISLLDLKNELLLSYIHNVVFLVLVRLRSGTLSNGIGADAVKELVKIRVLLERGVKPLEGKLKYQIDKVIAAASSSTPGDTTPATATKETIARNGKGSDEDSSDEDEDGIEHDDDDHEDSHRQKLRSDAVAAPAPVSTLARKELAFRPNPAALVKPSAPALSSLSTTNPSDGIYRPPRISATAMPEPSKPAEKDKPLRRKSHMLDEFVADELSTAPIAQPSVGSTIIDSGRVVKTARDRREERERQEYEENNFVRLPKMGKKEARELKRRGGREANGMGGEDWSSFTGDIERLTKGAGAGKSAKLLERSRKRRGDGDGGDGGEGGSSRAVGESLLRGGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM41</accession>
    <name>A0A2T6ZM41_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1088098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000184">
        <property type="protein sequence ID" value="PUU76560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM41"/>
    <dbReference type="OrthoDB" id="5151590at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="142" mass="16484" checksum="DCA72D54A53E9256" modified="2018-07-18" version="1" fragment="single">TSYLTEFEKGQIVALRKKNISLGEIGELLNHPKIRESKKARHQTLSESHNDVTPYSSFQTVKRVLASVNIKKWRARKRAMKYKDWIKKDFEGVIFSDKSLVEKSKDPKSMWVFTAPKEKLYKDCIHGVTRGTGIRLMVWACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMN5</accession>
    <name>A0A2T6ZMN5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lariat debranching enzyme, C-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1109286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMN5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMN5"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="359"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="281"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU76759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="555" mass="60910" checksum="E8CCA29B901342E4" modified="2018-07-18" version="1">MSAIRIAVEGCGHGTLNAIYDSIMRTCRINNFPPVDLLIIGGDFQAVRNLRDLNVMSCPPKYRALGDFHEYYSGARKAPMLTVFVGGNHEASSHLWELLYGGWVAPNIYYMGAASVLNFRGLRIGGLSGIYNSRHYAHPHTERLPYFPGEIKSIYHVRQYDVFKLYQIKEPVDVMISHDWPSGIEHHGDLDGLLRKKSFFKDDIEKGELGSPPARSLLNKLKPRYWFSAHLHVKFAALVDHGKSLGEEEEEMPMQEGGAERAVSPVEKNPDELDLDMDLEEATGVRVTSQDEIELDLDEEPETVASENKDEIELDLDERSSGNASVSLKNAVSENTKAGEPTSAAESEDAQASSAPLVEPAPALAGKNKVTNFLALDKCLPHREFLQLLTIPITKSKSGLSYDPEWLAITRALNPYLHKHPSALNSDAFKEGIGQTIAEERRWVEENIVTKGKLGVPKNFQITAPIHEGSPTAQEDRLPESYVNAQTTAFCELLGIEDGTRFAPPGSEAKEERYRSFVANGGGSYPRGGRGGGGRGGGGRGGRGMWGRGGGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMS2</accession>
    <name>A0A2T6ZMS2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1028259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMS2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMS2"/>
    <dbReference type="OrthoDB" id="2137750at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="162" mass="17704" checksum="FE9C28A7262EBDD9" modified="2018-07-18" version="1">MIRNFIRAVQTLPRRTMSSASNNPGNFANRPTEEVREIASKGGKAAQELRHQKQRDELPGHGNPGNFANRPREEVREIAAMGGRASHGGHGNTVQKEDLPGHGNPGNFANRPKEEVREIASMGGLASGGFANMDSEKHREVAAKGGRISQEHRHQQRSQSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN48</accession>
    <name>A0A2T6ZN48_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mad3/BUB1 homology region 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1051135</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN48"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN48"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="55"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="787"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="616"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1141" mass="128641" checksum="308BD03DB4179AE5" modified="2018-07-18" version="1">MADDDTTSFDQIELHKENIQPLASGRSARALVASLSSRSNPVLARAEHAAKQAEFEEELRGSLDLDDPLEVWVRYVSWTQETFPSGHSTDSGLLQLLERATQTFIHEQHYKNDPRYLRLWIQYIQNFSDAPREAFAYLARHDIGQRLALFYEEYAALLEKMGRKRQAGEIYQTGMENNARPTDRLLRKFEEYMQRLEHDPPAGDEPSSPALPAIRPALAAKPFGGGLSSGGLGTSPATQQQPQAPQPKPKQAKQKMAIFSDADAAPSSKAPNTIEKPTSGWENIGTLEQRKKENTIEARPWAGEVLKQEGVKAKSAEKMMIFRDESSLPKQNVPHVQQNVLPTSLPSNKRPERVAVNLELIYADEENPTEELSFDELRAIKRGQYGIDWNRIREEQAEEARERRRKNTHRGEVAEESRTPIKVKTVLSPSPNRGKIKRKGQAPASPTMTFHTRAATDEIYDIFNQPMKKTSMTGEDRDEDRKESGPEGGDGEDDDEDAGSVKSEWSDFTLRRDVPPRDSEEEEEEEVEGSPEVESAKAGFEKLAIHQDEPKAGGRTAIHRDEPSDEEPDLPSRPAPHKILIPSPPDDFDPPRLPYHAAKETQFQGQSRLPYMTPIAEKTESLPPTTARRKDVAKTPSRSRMPDIVDDNLMSSPFEESTNNSVFPPPLVPSQPAPSAAPARVPKERRPFSARPVAAARAKEATQKGPIIQDLQCNPMDESLRANIFDKLQPPLKTYEGFYEHTTKFGRGAEIKRFTKAMSKRDGEKTTANISQAPIVEFVTGDGGSSYTIKRELGKGAFAPVYLVENNIVADAEDEAEEAGPDDENAADLLSLNKKIIGRARFEAMKMEHPPSPWEFYIMRQAHRRLGVSRPVESILKAHEMHLFTDEGYLLLEYRDQGTILDLVNIARAEVGTGTNTGVMDEQLVMFLSIELLRTVEAMHSKGLLHGDLKADNCLIRFENTPDNTWSARYRRDGSNGWFKKGITLIDFGRGIDMKLFQPTVQFIADWKTDNQDCAEMRELRPWTYQVDYFGLAAIIHSMLFGKYIETTADRGNILGGGTKKYKITSSFKRYWQTEIWSSMFDVLLNPLQYVMDEESTCMPVSKSVRKCREEMEAWLEANCEKGVGLKNLIRRMEGVLGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZND7</accession>
    <name>A0A2T6ZND7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1109134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU77009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZND7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZND7"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="156"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="321"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="851" mass="97008" checksum="B63CC231BD841A6F" modified="2018-07-18" version="1">MFEDHWYHSSSQPEFSSLRRQESVKRHSPERNSQKVAEERKTPPGPPEADIPRRPKSYTDLRALEWQVDASLVPKAKQEVVNGIAEELPSRPKSRNDLDDLKTERYGRGKWLKARGRGRRATKKPKELKDELDFADWYGEFEDDLRDADSEHKLFQYTLDSYLTTCNSLISTTDSTLGLLTELEKSFQTVHSQTSSFQETCSSLLTYQGHITSLLSSISTNLYPFTELDPITRALSRPGSDFVKTPSFREMLVRLDKCLAWMNDPAHRSFHDVENYAPRFRQNMTRALTLIRNYFVTSVREVANEVMGRIKERQMNDTTQSALLYAKFRVNAPLLRELVGEIEKRCDHEEYISLLNECYSAFSSVRQKLIIPIIQKKMNELAAAGASTNKDLVKFSRNGINFVRNICMDEFELFCAFFSGERSDSEAYNFLETLCEPLYDHLRPRIIHELQLVKLCELCALLQTRYMRDPEDPESDPYDRTQLDFGQLIQTTIQDTQNRIVFRAQTVIRDEIEGFVPKPQDLDYPAKNQSEKRALKTGEIPGTPLPGAPTVIDHDDNPSGNGFDTEAVFKGWYPTLRKCIWLLSRIYRLVNSTVFDDLAHNIVHVTTVSLLKAHQQIASKKTPADGYLFLIKHLIILKEQIVAFDIEFVRPDVNIDFSALTGTFWGLREKGIFSSEGIIKLVKGAAMPKVVENMLDAKVELDARLRFAINEFTHHFASRMTSGITGPSNQLAAASATDPAKVVRIAVEREVATLRGKLEEYLEDGRTRETLVAAVQEHVIQAYESYYEEIFLRDNKVPPRSPGGTVWDVEMFVGWSNDIFAVGHGFLAYDGDGAESEDMSPGMSRAGSLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP10</accession>
    <name>A0A2T6ZP10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_957282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000158">
        <property type="protein sequence ID" value="PUU77228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP10"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP10"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="9013" checksum="548D56A3C862EC49" modified="2018-07-18" version="1" fragment="single">VPDRDGNNPLDNAGVSHRWSMLKALVKQSAGRRAYSSEINQKNHTGNTPLHLAYQFNHTEIAELLVKGGANPAIKNNAQIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP84</accession>
    <name>A0A2T6ZP84_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_987346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP84"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP84"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="213"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="363" mass="40868" checksum="AFF12C24A6E7C953" modified="2018-07-18" version="1">MPPIIDSHIHLFTREHLPHLAWSTPENTLYEENSIPEYLSGIPPSKLADFKGFVFIEADRRYTIPSDEAISKNDTVALKKAWEWPLEEFEFVYGLSKTHPHGKYVLGIVPWVPMNLGASAVERFYELLGVEGEGGVERKRMLKGFRYLVQDKPSGTIGEVKFRESMGWVWKKGLVVEIGVDTRSGGLWQLEEAVKAIQEVVKDSEHAGGVGAFVVNHLCKPDLQILPSEIPSHPTFQAWKSNLKVLAAAHPSIVMKVSGIFAELPHDESFSKLTASQKEDAVIAHVTPWISETLSIFGPDRVIWGSDWPVCKMGFEKIYPAGEFSAWETWYLLATKVMLKLSQDKDVMEKLFSGNTARVYRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPA5</accession>
    <name>A0A2T6ZPA5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_987314</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPA5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPA5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="104"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="360"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU77321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="416" mass="47701" checksum="77FE3262E0A92FBA" modified="2018-07-18" version="1">MIPEHQQQQQQQQYQSSTHQPQNQPHQSNINSIINPPQSGDYPRPYDGNNTPTGAAHSNIAQPQETGNSSTGNASQERRSEEQQRQQQQAAVRATKGKYSLGDFNILRTLGTGSFGRVHLVQSRHNLRFYAVKVLKKAQVVKMKQVEHTNDERRMLQKVKHPFLITLWGTFQDGKNLYMVMDFIEGGELFSLLRKSQRFPNPVAKFYAAEVALALDYLHSHHIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVSSKGYNKSVDWWSLGILIFEMLCGYTPFWDGGSPMKIYENILKGRVKYPAYIHPDAQDLLQQLITPDLTKRLGNLLHGSSDIKQHQWFAEVNWDRLAKRDIEAPYVPPVRGGVGDSSQFDRYPEEQDEYGVDDGFDQYGHLFEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPX1</accession>
    <name>A0A2T6ZPX1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1086118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPX1"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="132" mass="14155" checksum="A959D99F68FEB397" modified="2018-07-18" version="1">MFRFHKTLDVLTLFHAPASTASKRILETLRSSPTAHKKSFELDVVEAPTVPTPTQLTSILEFIGKNRVGEVVPGARSEGDAVRLLKVEEAGRKEGGGGGMVRPLLVDWNNGRAVVGGDEGAVLRLLETLPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPX7</accession>
    <name>A0A2T6ZPX7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1086195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPX7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPX7"/>
    <dbReference type="OrthoDB" id="5377623at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF7">
        <property type="entry name" value="TRP-LIKE ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="627"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="54"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="824" mass="91436" checksum="386984FCACB2C1B4" modified="2018-07-18" version="1">MALSWWWWWRRRRWAFGIWSILICGAGAQGRINFNPDDGEISAPPEDLRDDRKPALYTAGYGDCMEDSAIKITRFDAAYYSDNMTISFDIDGYTTLVNESLMIHLSIVAYGESRFDLIFNPCRTNIPSLCPVTASVNITARHIIPISMDEVSGIPAIAFTIPDFEGRADLRIFSNSTKSQTACVTALITNGNSFSHPKIISPILGILAASVSLASFITAMSGGDSAVSSRKFYAHSLSAYTLFSCFHSIYLTGTLSINFPSVLLAFWSNFAWSSGIIYLDSMQRSLNRFTGGARLVHGSLALDSTAFEMASNLYPLAKRYVRFGKHQKAGLPKPGSFTGFSATLAMSQVTVSNAFITSFLWSLILLVAVAISIIGLKLAINASVRAGIIKENRLLIFRVSWWDYLESTLCRVFLIAVFPLISLATFQFTLHEAGPSAVAAFVFILSIVGLSTAAFAAYRTRWRGGRVRVNRMNRVIYPRLRVGFIPWIFVSRRSSIDGTKKKIIMPWWELSIETDGERSSIHEDLRFIRQFGWLASRLRRRVWWAFGPLLFFEILRGIFHGGGSGNSKAQVYGLLIIETIYFIVLAYMMPFESTRLNVFTAYMLPIMRISTLAILCVVLATPGLNRIIVTVLGIVVIVIQGATVVVVIAFALINLYATYLKIAPRGTQIRPQSMNPTREKYLAHIEKRTLDLPTVHSAQRRSSATGPAPSSFSVNTIRRCPKIDDEYGGPARSVFSRNSYMGSAAWERGEDEPVSRVGSPNYSLARLQRPVWRSDSPGFANASEATSTSPCPHANSDMDPHSCRDSEEQLKDASSTVTAALKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ66</accession>
    <name>A0A2T6ZQ66_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1049925</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ66"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="219" mass="24264" checksum="B077DF8CC20FF89B" modified="2018-07-18" version="1">MAQIFPTLIRHYDTTFAARPLLTMMVTNTFLCAIADTTAQTITSTIATTTTSSTTIHTLDKAIPGKKKPPTPQSAQLPLPPPPFDWSRLIRFMSWGCIVAPFQFKWFQFLSRRYPISGQGGAMGALVKRVGLDQVVFAPVGLAGFFGWMTVSEGGGWGDVKRKFGEVYFGALRSNYILWPAVQMVNFRLVPLRFQLPFASSWGILWGTYLSLTNSAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQM9</accession>
    <name>A0A2T6ZQM9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1065587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000141">
        <property type="protein sequence ID" value="PUU77790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQM9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQM9"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="466" mass="51520" checksum="73F7FD70E3B602D3" modified="2018-07-18" version="1">MSWGLSKELQNPPPLRRSSRRSAAREAISAITEGKKLGVHAPPNTKKGRIATHRAIASFAEDGIDGCEDINPISIHPPIALSEKQRNQPERDMKDTVRLDDILNSPPSRTLNLARLKKKRNIQSRTSLAKRRTWGGDGFVALAVRIACSAFTSLVQSMDVVSFLYPSLDELKKVQIPTNFDDNLKKLKDGIPTFEEVKKAANDAIKILFRLISVFNESIGVSEFNRSISPIPELENLTFCSGNPKINNFYDDLESTVNKVKKTLIGVIICLVILAVIPMSYRGWWNWRSTQSPAFMLHTAPTYDPIDVIQIASRPYSSAGLFESSRRQILVRWAVAYATLTPALFVLSLGIAGLFGVLAQYLLLRQVESTAPASAAEVGEFADIVVKQLTVALTSWAVKTNAAINSTNSDINKKLFRWVVNGTDSLNDTLTVFVDTMYEGVDKFFGKTPLANPIKDVLNCLIGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQZ4</accession>
    <name>A0A2T6ZQZ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1049459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQZ4"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="231"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="340"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="448"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="547" mass="61356" checksum="C3A7599532F44B96" modified="2018-07-18" version="1">MNGDSYSSRGGVFLEFPDRHGYGRDYHGTDHRRERDRDSRGDRDRGERDRERAGRRDRSRSPHRGRSRRDDYFETDRTDRYRERDRDTDRYAGRDRDYERERRRGGGGDRRGERNPRYDEPRGGRSAAAADAFPVRKRSATPPVKKREPTPDLTDVTPINERKRRMTMWDIKPQGYENVTAEQAKLSGMFPLPGAPRQAPMDPTRLHAFMTQPSNVATASTLKPTNSRQAKRLLMSNISPGTDEESLLQFFNQTLSSLNVTTGGPDPITSVQLSGNKTLGLLEFKNTNDATVCLALSGVEFNGSNIEIKRPRDYIVPIVSEDHRHQEPGVISSDVPDTPNKILISEIPEYLQDEQVIELLKSFGDLKAFVLVKDVTDETSKGIAFCEYLDPGTTEIAVEGLNAMEIADNTLRVRRASIGMKQAAGVEMGVNAMAMMAGTTSVDLEASRVLQLLNMVTADELLDPEEYDEICEDIRDECQKFGSLVDMKVPRPSGGSRQAAGVGKIFVRFETQESASNALCSLAGRKFADRTVVCTYFSEENYEVGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR83</accession>
    <name>A0A2T6ZR83_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1049257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR83"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR83"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="53"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="731" mass="81046" checksum="BD8E6F51C8237060" modified="2018-07-18" version="1">MAAALIGNNHYNKGVGGGGKFASIELLTLDSDFTQEESNSFSSVRKPIWYTGWHTGVLVSATSAVIVLFINIGLTIYAATNPRYMMEGRIGTLYSGSCDKTKTIELWLHLGINALSTLLLSGSNYTQQYLAAPTRSEIDAAHAKRQWMDIGVPSVRNLLRIKRERALLWIIIGFMSIPLHLLYNSGVFTSLAANEFFITVVSNNHFEPRTYRNTTKTQISTFQDMSLNATTGRKYGDVGYQTNSSKIQLFSSMLEGLSPSTQGYEDLTSLECAKVYNTDFVSHHRNLFLIAKHISNPAHPGTILAMHISDLRRSSPSNWICSDDFDPQSTDCCDPSEPTTNLTSGLQWWVKLKTVGEVEIIGCKSEITNEKCKVQFSLDIMIVVICCNLVKACCMVMAVVRSREPTLVTLGDAVDSFLRTPDQTTIGICFADRQFIKREWRHGWKTGPRQWKQKGLHRWWTSVSKKRWIVCNFFCSITIIAAGVLLRFGMISDGELRDTDLKSMGLGKVNGISLVRASFRNITHAILIANLPQTVLSFLYLSYNSLFTCMLAGHEWSLFGHHHRTLRVTSPGPGQRSTYWLQIPYTYAIPLMTISGLLHWLTSQSIFLARVEIWDSFGRETPSPISTVGYSCIAIIFLLTLGILALLTAAGMGYKKFAAEITTVGNCSAAISAACHASGPGSEEITGEKVRWGDVGIASNLGVRHLTFSSEEEVRKPEFGEAYAGKMGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRE9</accession>
    <name>A0A2T6ZRE9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1085070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000132">
        <property type="protein sequence ID" value="PUU78004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRE9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="65" mass="7697" checksum="D26E276C7FFFD6B7" modified="2018-07-18" version="1">MPPLKKECHSNYYPAREVHFYRKAKIGHEYITSLKWSYVSTSSLGRRRCSITHIQQLYHSSLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRH6</accession>
    <name>A0A2T6ZRH6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_102881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRH6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRH6"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="105"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="273" mass="30330" checksum="775493FA15E98E23" modified="2018-07-18" version="1">MIQNPIKTHTRKTHQMLRIPITRSLTHSLIHPIPPQFLRRSLPQLPHQKTFTTTPHPQKKSPAKSPKAHPYGENVQDKKTHGSPFDYAAHFESLETQCSAHIDKLKTDITKLRAVGRNDPSVLESIQVVLNKSTGASASLRDIAHVLPKGRSLVVNVYEAANVKHVIAAIQKANLNVQPMPDPKNAQSINVPLPPPTKETRMNAANMVGKAGEKTMALLRLARQDSHKLIKGLKKERPDDIRKADKQLEVVMKKVNAEAKKVIDDAKKGALEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRJ2</accession>
    <name>A0A2T6ZRJ2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1084751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRJ2"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU78083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="501" mass="54057" checksum="9B19C7FCAD1262B3" modified="2018-07-18" version="1">MASPTTVAPPSTVNIIRPAEEFVRGSAKRTREVFASDFGNPFLLDDDTARKQSISCKIRLEYATVRELPPALAAKQATAKKAKRIGGGVAPVVSKPLLTEADGVDGSTMKMVEGVAAKAGGASASTSTSLTIRGRPSSASSGARVGGGAGAGTAQRELPGSSLVRKNNAAAQQIKPIWHPPWKLMRVISGHLGWVRALAVEPGNQWFCTGAGDRTVKIWDLATGNLRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLESNRVIRHYHGHLSGVYSLALHPTLDVLITSGRDGVARVWDMRTRTNVMVLSGHQGTVSSVVAQEADPQVITGSMDSTVRLWDLAAGKSMAVLTHHKKSVRALATHPKEFTFASGSAGSIKQWKCPEGAFMQNFEGFGGIVNTLSVNEDDVLFSGADNGEMCFFDWKSGHRFHKIDTIAQPGSLDAEQGVFCSTFDKTGLRLITGEADKTIKVWKQDENATEETHPLDWKPTLQRMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSM0</accession>
    <name>A0A2T6ZSM0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_71841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSM0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="222" mass="25430" checksum="688B8CED12C20071" modified="2018-07-18" version="1">MSVCMGKRNRAVASKQALEFSLHIIMTLRMFYTYRLGNAWPITHPPETFSLTSPSQNNNITAKQMFPKLTNYAAAPGIRLRLRGIQGKYLTTQSQPSSPDAIHLSSHPLPHHRPVLPVLHPATAKRHHKAKAGQISIFAHLAKVKQVEEIWYQRNRQAAMDANQQKDKLYQDVNQQKDKFYREITTHVAENTRLQIEVLKEVDKRLRVEGNFNVRGGLGMFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZST3</accession>
    <name>A0A2T6ZST3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_67165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZST3"/>
    <dbReference type="OrthoDB" id="5356047at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="21127" checksum="ACACDD6CB73F2968" modified="2018-07-18" version="1">MVEPQSNNPYRRSMSPQLPALPAPAALPESTNLSAHPAPLQKSYSTTTTIAEEPELEDAEGQTPAPTYPAVNMDQNTPTVSIPHGPKSADKSTSDSIVITIHPTSSTCTVQNPAEYPMPRPSMSTHPHPRLSLSCEEGRPCNAWPARRFLQKQVMRNKTKWIIIKVVCAVLFVVGAVAIGLGISHATKNKVNRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTV0</accession>
    <name>A0A2T6ZTV0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1101126</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTV0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTV0"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="8915" checksum="963E8D1B08A38BDD" modified="2018-07-18" version="1">MRSYQFSVVMSCGGCSGAVDRSLKKLEGVDHFDISLDTQTVEVTTNDSLKYQDVLAQITKTGKKVTKGTEQVNGVWEAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTX2</accession>
    <name>A0A2T6ZTX2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1125964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTX2"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="191"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="501" mass="57390" checksum="E49D9C3572107DCD" modified="2018-07-18" version="1">MCEQDSTTVIENEWLSPPRFTAVRSSVDLTGVREDATGDFDIRGLGQAVNTYMANQALIKAWIDRASERKSTLVFCIDIAHVRSIMLKSRAHGIDARDVTSKTSTQVHRECLKEFKAGKFPVMVTCGVFTEGTDIPNIDCLRKLENTGETDCHIIDMVANLSHGVVTTPTLFGLDPDMVVNEMTPEQMFAAEQERARVEKEMWKKEEARLEEDIRKLKEKWKAIEEEAMKVAEQARVKAKKAALAAERRKAEEEMRKAKSQAKKLAKEAEHQILQEEKRLRAIAAEKFKQGALGKDLPSRTNQVFYSISRLAWVSIGPTKYILSCGRNGHITVETDSNEWYNVEEVRALPLELGRVRWTWSKPIMSGIEQLDLAIRGCWYYFPLPPNLFPLTWSYLTDTYVLKTYPRHLVARSALWRKLPASDQQVEFPKKIRFRGDKDWEDMGNSGELTKGKVGDIITRVKHGTVRLFSEKKKEQKNKEKEEAKKLMRRQREEVKVGSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU63</accession>
    <name>A0A2T6ZU63_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1125773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU63"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU63"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="581" mass="64115" checksum="D466554B0BD991F0" modified="2018-07-18" version="1">MDNLQSDLIVWYKLETEFLQNRVRHTKYLGKAKNRNKKVKEDWSNCGELGRGGFGVVHKQVESTTGSLRAVKTIDKRPPLVLDYSRELLVNAILAKRPSLFVEFLGWFEGPKTLYIAMEYLEEGDLSKHIGTPLPRETVQNISKQILEGLGVMHQQGIAHRDLKPANIFAVSMSPVWVKLGDFGVSKRILAQADTTLHTPVSTQAYSAPEVLGLDSNSETSDYTNSVDIWSLGCVIYELLVGTKLFPSEGQLCRYYFGKLPFPEDKLKGLSPPTDDIGISLLKSMLLIQPEDRPTAAAALNHAWLAGIHRDNEDSGQDQDEVTQSRDESTRSAKRKNSLSTHGRPKKRRSKRNQATLGDIRSIPGGVAFGAGAGSQGGGDLRTQNTVINTSVITRSRADTASAESLGAETGPRRSELMSHNSQITNSKGRYALRENNTRYIPQTGLQDLPQAAPERPTPTVEIVSNPPGSPMGQWNTRERKCTKSPPSPPPPPATELDRELPTSESTLPGRAGSNETIRRIRRTKPNTAATRMDRTINPMRNPNTWRNINRGRERNAKQTPSAGSNPNTGGSRNLGWNSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUE9</accession>
    <name>A0A2T6ZUE9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUE9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUE9"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="115" mass="13223" checksum="A5D3301DDEDE5079" modified="2018-07-18" version="1">MKLKTSSATFEKPIRHQHLDELYRELDAIHWGWKLIASCANWMMLAGFVVLPSAFDDDESKFRVDSKVLRACAVALLLTGYITTGMLCYTFKNILFQVEAIFLYTVSPKLRFMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUL8</accession>
    <name>A0A2T6ZUL8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1082342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUL8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUL8"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030666">
        <property type="entry name" value="IPP_transferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039110">
        <property type="entry name" value="IPP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="501" mass="56746" checksum="18C488D8D5186F74" modified="2018-07-18" version="1">MFGILKRLLRFRTKAKMTGSLPPLISVIGATGTGKSQLAVDLAHALNGEIVNSDAMQMYAGLPIITNKPTVAEMGGIPHHLLSFLPIDEVYRVGQFVKEAEKRIEEIRSRGKLPIVVGGTHYYVQSLLFPHSIGTEGEEEYPFLPATGGDLAIKYPILDSPTPELFAELRRIDPEIAEKWHPNDRRKIRRSLEIYYSTDGKQTASEVYAAQRAEKEVSRHRNLVFWVHAEAEALKKRLDARVDKMIDGGMWAEIEEMKETYDSMEVDMTKGIWQSIGFKEFLPYLQLYDSHQQQQQQEPEPDPKVVKKLQAELARVRARCVETMKTATRQYARTQTRWIRIKLLNALRPPSHIYLLNSTDPSAVTEAVTNPAITLAEQFLAGGNSSLPDPCSLSALAEENLKPKREDFSSRPDLWVKKTCDVCGVTCINEDMWGLHVKSSRHKRLVKKAAMKEEVEGYIHAKKEERDGKRVELVRVLEKRAEDLAELEIFDEGEVAGAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUP3</accession>
    <name>A0A2T6ZUP3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_845338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUP3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="132" mass="15430" checksum="E4AD5724FD46A267" modified="2018-07-18" version="1">MSVYYTRVCLQPLLKARGTDGQIAKWDRKTKRGIEQQQPQLLGPAWSLAPGWLAGYICLFVCRSSGIPRWSDFYFYSSFSLFHQVFHLLVRFVLLVSWGFAYIFFYLSRHIVYLFVFAYCTFLSSFLCFATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUU6</accession>
    <name>A0A2T6ZUU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TAP-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1082244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUU6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUU6"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="272"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="418" mass="45644" checksum="251FFF06F0CA193F" modified="2018-07-18" version="1">MERDGEKVLAGGSEVAEAYSRFKALSESCETVAGEEKGGYVNTASVARDMLEISERLWGLSGVRGRGLQYWGLSYGSVIGSTFAAMFPERVERIVVDGILDTEDYYSTGWRANLQDTDKVLASFSTYCSQAGPERCAFHTGSTPEDITIRLHNLLQKLSAEPLSIPSSRSPTNAPEIITESDVRNLLFVSLYAPLGAFTILAWILLFLESGDGTGYLITARTSFNCDSPGSSKTPNTGAETMLAIACSDGAPVPDDRRAFDKYLRELTSQSKTFGGVWARLRLACTDWKFRPKGLAFSGPYRGNTSTPMLFIGNSRDPVTPIINAHTMSKRFPGSTVLEQNSEGHCSISAPSLCTVKHVRRYFETGEVPPPGTVCEADMKPFMGAGDHVKTMSAEDRELLKGLEKLAMELKPRSWHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV34</accession>
    <name>A0A2T6ZV34_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV34"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV34"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8697" checksum="A48944360E414E99" modified="2018-07-18" version="1">MSIPYFWAQPFRYMRYAAHQYPALFWSVMIGAQGPLIFFGGVWAKKKFGWDRPTIPLSYPVPNRPRRIPAGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVI3</accession>
    <name>A0A2T6ZVI3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1064192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NSA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVI3"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22858">
        <property type="entry name" value="Nsa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="462" mass="50216" checksum="DBC3A4B167BA213E" modified="2018-07-18" version="1">MKFAIGDDIGQLKVITAPRGTDSSLKTSVRARISTYFTPDRKEPVYAVCKIDKYQGEERAGLVAVVFTSGKVKLVDTSVSPINGEGKYLLYTHASPTIHSAPAIASPVVSAGVQDDILYLFRTNGEVVFYRFDGKSPSVKTVPLPGNAAAGAVFTEALVDGWPGAIAIGGEKRDLEIFESATEEGDWKSVWKAKNVKQDKLGLEVPVYIRRVLFLGAGRGEIAGNTTAAHPRRPTTVQTSGGKYRLATGTHYSHLRIYDTAVSRRPIFTTALTKSPILSLHLHPSTQSPSPTSTPLTVPNTPPELSTTSSPHNWIYTDSNGRFALYSSTNRREVGIYKGSTGAVNATATFSKDVVAGVGFDRYLRVYEGAGREVVVKAYIKSKGTAIVVLDGEDEVIEVERSREEVEEEEVWEDMEEVAGGGSDERDGGEEGDFTKALVKVRRRRPRTDKEGGGSKKRRVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWA3</accession>
    <name>A0A2T6ZWA3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1192385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWA3"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="26902" checksum="CF5AC247B52BF4FB" modified="2018-07-18" version="1">MSLSLNGRNVLVTGGSRGLGACVVQRFAAEGANVVINYVSAADRAEALAKEVREQYGVRVLVICADVGSDRECQRLVKETIEGLGGLDVIVSNAGWTKVSDWKDLYALGEEEWDKCWAVNVKANLHLLRAALPTFNANPDGGSLLITSSIAGIQTFGSAMAYSVSKAAGLHLMRCLAYTQGPKVRVNAVQPGLLMTEWGKNFPQEAIDRTKERSKLKVAPTIEECADAFVLMAKSSSMTSSTLKIDGGLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWC3</accession>
    <name>A0A2T6ZWC3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutaredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1081007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWC3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWC3"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014434">
        <property type="entry name" value="Monothiol_GRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005894">
        <property type="entry name" value="Monothiol_GRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="9">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="11639" checksum="68E7BDB70D9149D9" modified="2018-07-18" version="1">MKGTPEFPQCGFSRASIQILGLQGVDPKKFAAFNVLEDNEIREGIKEYSNWPTIPQLYVNKEFIGGCDILVSMHQSGELEDLLEKEKVLVPPEESADANAEKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWD9</accession>
    <name>A0A2T6ZWD9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1124673</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWD9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWD9"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="560"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="230"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="525"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU79809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="626" mass="66609" checksum="E0A09DABF0C44AAE" modified="2018-07-18" version="1">MSNRNSTPDQNSVTGGSSLRPPSSRPLGSGHHLRASADMSGAFQSPLAGRIRPSSEIFLNPPQITSQNAETEALDKAAREWINDLETYENTLEEMASAALDQDFKDELSAIEQWFRVLSEAERTAALYALLQQTTQVQIRFFITVLQQMARSHPMSNILSPNTFEKDAMASRMNDAMNKLNMGSTRDSFSSRPPPSPGAPPNRNSGVDPSVQSMFPDAAAAIAAQRALISGQPGGSSGTKSNRNSALFESRPSSSLAPTPSISTPANKENNPPSSPWNRPTNDGGSEQNRPKSAADSMGNFQLPPPSAGLRSPRNAPPQITGNTNLQTTTLNAPTATSIEMPQLSPYGDTSGNWASMVNTPVAPMFSQSPGADMVANAAAMKLAALSTVNNRIILDNDPKGWGKRRTGKDPNGSNEHGNVGLNSPRNGNMPTLSPSTITMYNEHGQLVQIPAAAAAAAMAQQQNNGSPLLGGRSRPNSPGVFNSPAAQWGGMGFASPQAGGFLAAQSPLLGGGLLNTFGSLTGSAEGYNSDDVSGRGRSPRGRRGSSKPPEDPTDPNLLNDIPAWLRSLRLHKYTDNLKDLNWKDLIELDDEALEKRGVNALGARRKMLKVFDQVKEAKNEGKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX47</accession>
    <name>A0A2T6ZX47_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1100492</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX47"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX47"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="350"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU80071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="492" mass="52863" checksum="042F39C4E5A279EC" modified="2018-07-18" version="1">MSRPPLSLTAELEKLEQSITLTLQEIDHNFSKAHRIVTTSIIPIVERYAKESEAVWDGSKFWKQFFEASANVALSNYQEEEEAYEETGVTTNAETYITASSPGNYGEQSTRITQEDDPRHRPGPEENEDDGDNDYLLDDSLLDSLNLTAGGLGGASTPKGKQPQRAETQWGDIESPFDALRKELAGKDYTMHRSPTTTTNAAAAVPAVGATGYEDSFGDDDVDMTFDEPTLPTTPLSRRTRPVKDSFETPKSSSFYPAAAAAATGAIGKKTPGGANEDQLLHRVLDKNWRLQATPLGKPAPSRYRTTGTAAAATTPKAQILPPPESESPMSSPPKPHFYSADIFSSPIPGFSGFGGGKKPKPSTTSNTSNNTTAALAGGPKTPTSRRYGTAKVTTTHHHEFGQQEDNEDRFAYGYDDDDDSDDLDLPPGLSPPVTIQFSLPPSKLLATPAREASRRIVHDILQTAGAADESGATGGSSPPVVRDVGPLDDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXC1</accession>
    <name>A0A2T6ZXC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_761772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXC1"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="26"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="383" mass="44274" checksum="55C205E049FABDE8" modified="2018-07-18" version="1">MPTGHVDNAIGIANLPNQRHKIVAKRGAAFTIMVVGESGLGKTTFVNTLFSTTIKNYAEHRLRHKKQMDKTVEIAITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWMPIIEFLDDQHESYMLQEQQPRRTDKIDLRVHACLYFIRPTGHTLKPLDIEVMKRLSSRVNLIPVVAKADTLSPADLTTFKQRIRAVIEAQGIKIYQPPIEEDDEAAALHARSLMAAMPFAVIGSEKDVKTADGRVVKGRQYSWGVAEVENEDHCDFKKLRSILIRTHMLDLIHTTEEQHYEAYRASQMETRKMGEARPRKLDNPKFKEEEENLRKRFTEQVKKEEARFRQWEQKLISERDRLNKDLESTHAAIKQLEMELENMQGSIARSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXF4</accession>
    <name>A0A2T6ZXF4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1080125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXF4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXF4"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="82"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="511" mass="54651" checksum="9B0B90165729C1E6" modified="2018-07-18" version="1">MSGGSMSPISISSPLPTSSPGPPALAPRAASVVGNSTAAPNTIVTHKEWIVPPRPKPGRKASTETPPTKRKAQNRAAQRAFRERKAARVSELEDKLKELQADHENRDRISKDQIEQLTEDNVRLTKELSEYRIRMESLQKELDLIRQLKSEDEASAANFVTQVASPAPSSSHDTPCGGNCTCTDELDQVLCIKKAGITLSAPSVPLRRRSGRNKPQPSLGDSRVPDPAGCGRCSKEGSCACMAEIAAALSTKRPTSPSQNTPKRTRTGNYAENNSEELEIDFTNAYMTKSTPITQMPDPCGFCSDGTPCVCAEVANSLIANDDSEENHSTKLPPLRDGHSSVLTSHTQQGLERPVALYPPMNTSAVKPTSRPGGCQPGGCAQCQNDPLSTLFCQSVATKMNSAEKSGCCGGGLCGGEIEGSRPSTSDSKEKAKTDEGASENGTFIPCSAAYQTLSRHRAFEDATTDLGSLVRPLMVRSLDGSCPQIEVSSIREVLRRLDRGFGSDAGKYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXG9</accession>
    <name>A0A2T6ZXG9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1079971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXG9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXG9"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="13641" checksum="6D8B6EDE6BE5FA4C" modified="2018-07-18" version="1">MNAPDRFELFLLGDGETKVSMEQDTRQPNAAIFTFNKEDHTLGNLLRATLIHNEHVIFSAYKVPHPLFPKFELRIQTDEETTPKEALLAACQSLIGDLQMLSQKLTREWELNKIARDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXQ0</accession>
    <name>A0A2T6ZXQ0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1079680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXQ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXQ0"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="25582" checksum="45B619CB660F493E" modified="2018-07-18" version="1">MANISARVSIRWLPAPASEPTSTLVTTSPNLKFVDLRLPASLDDSTPPQWAIAGRTVVGTPMRWVHEIDSRTDTPGEDSGVNTLLLNGDTLEKGRMVDDEDGQVKDYEEVWRNVDIDEGIALVLECDNDEGARGRVVRVGGYCQGMVKVGERTSCERYVRGKGNGKWERVYRYGDAKMPCDLACLDRGLLGRSGEAQLSGEDGNKATLEREVNIGDNFKVNGYTWKVTEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYQ8</accession>
    <name>A0A2T6ZYQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transport protein particle component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYQ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYQ8"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="22722" checksum="3240B82557702169" modified="2018-07-18" version="1">MSFEPPLPPFNASDPHATFLNSTCLDLLLIELVPLAHRLSQQLAETATTTASPHDALRGGGGVDDEEDEVREAVFYRLDMLGYRVGHGLVERFSRDRPRMNDTLDVIKFVCKDLWTIVFRKQIDNLKTNHRGVYVLTDNSFRPFSRMSAETGGNAVARAQPFLWFPCGIVRGALANMGVNASVQAETTELPSATFKIETLSKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYV7</accession>
    <name>A0A2T6ZYV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYV7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYV7"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="448" mass="50948" checksum="47D00E970C390BD4" modified="2018-07-18" version="1">MGVDMMVPMANGREQGHVGTRKFGSQDGGFDRALTNEHELQETIAAAYRRMSRDELSLLLSLRSLPTCGETIELAFRLAVHELSHRTDLSLQRRHTPRITPPLSASSSFSEYPNQINNSDNSSNGDPDVDMDAHELDNAPPRIDTPPPQNTNLPVLPPELWADIFEALNDWELSTALGIRTKLRRSAEWAMNGTKLDYAVLSGSVEYVTSFLGVYPAEKVTKFGAKAMLRFAYTDLLTFFWTNYRHDFLRVYSEPSLNIPTLASHYGQSKVLTWWLEASSPDLPNPFPREYDEEPLNDASREGHIHVLQWWKSSGLPLRYGLVMDVASSFGHLTVLEWWKNSGLTLNYLHALKGASYRGEVEVLEWWKKSGLRLVYDKEVLVDATKFNRPDVLQWWSSSGLRVEYCVCDIEAALEDAIGGGKEAKDWWLGRGCRFDVPVTEWMEYKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ47</accession>
    <name>A0A2T6ZZ47_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_698341</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ47"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ47"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0799">Topoisomerase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17737" checksum="3BFFD5D52C3B0AD5" modified="2018-07-18" version="1">MFFLSDTLFKNVVKNTPVISNIIDYANMKADKQLKQTDGSRLFRINNPKLIDANRAGTKDSQECVLILTEGDSARSLAIASISTIAGRDRFGVFPLRGKLLNVRDASHDQIMKNVEIQNVKKILGLQHKKVYESRKELKLPLGTTYPGWMEASPFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ66</accession>
    <name>A0A2T6ZZ66_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_973699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ66"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="131"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="31712" checksum="0A139121601E7873" modified="2018-07-18" version="1">MDEFDALKSESPAKHHPEDDSESTSEPDSDSETVRLNRAEEEEEKSQSSRGRSIPGTSDRDMMFKHASHLSGSFQTGVKGVLSDAISYESALRKEKLQKSTNAIHTGYSQSSRPRGTSSPPRVRDRNSDGESGEEDFVKTWRKNRMQELRTGQSNTRRRSPSKRKYGRVEVVDAVGYLDAVERVSSETIVVVTIYNDKSEESRFVEDCLNTLARRYATTRFVKLHHNEAEMDVAVVPAVLAYKGGELFANIMRIVDEIPSGRSLSTDSLELVLRRANVLHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZL0</accession>
    <name>A0A2T6ZZL0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_666736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZL0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="118" mass="13240" checksum="5F2ED010E0E47D1E" modified="2018-07-18" version="1">MTKSSPVTKRELGADTFSLAHITITATSRGRKYRIVCILVPLLVVTSPHFSTFALGSSRWPGYPIRCSGLFVSATGQFCASAVHGFVTRFYRRYIWKPVMYLFSVSGGFLCFLMLSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A005</accession>
    <name>A0A2T7A005_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B9Z19DRAFT_664459</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A005"/>
    <dbReference type="STRING" id="42251.A0A2T7A005"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000001">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="22">
        <location>
            <begin position="576"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="233"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PUU81041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="970" mass="107542" checksum="7E12AE0C56BBC3AD" modified="2018-07-18" version="1">MSRRTKSFFEQDHSAKARAPYSYNRRGNPNPLLQQQQQQQNLTGGSPSTIPPSKETKAKLNAFAFGGLTPRRKGRGSGGGKGEEGDGDGKGDAEGLATSDPTKECPQTPAPRLALSDLIGIGEEGKFPQPAVQSDVSPEDRIMWQLSPNGSQVTPKVKGKGQKRKRDIESPSGDVAARDSPAQRKPGTLNLQDLDTDLRTPSADPATQLWSKYFTNTNSGSAAARPVNPAARLFNGGEASQNGAPDLSPLGLKRSYSCGPDWPGHSRLKKRKINLELGSEASIAEEPTENPKSLTTGANGPGPSRLSRVSRLVDKVKETLGKPSVLPNLPSSSSPLPERHPNFELTSSPLGGGGLRARGSPSLGRGIALGEETAPVESSDSEDFGEFDEADIDMDMLEKVEELVRDSQSQTQAKPIVEDSCNPPILARQQPVQPIQEISEPFAAADGEDEFGDGDDDDFFTQNLEEMVAKFDTPAAGPTLASNLTGSSSSQTLGEQSPDAKVRDQADENAKFLEEFGEIDFDEWEEEELKITQGLTDINAKVIKRYLVLEISESQRELGNHFSQNQKVLKVKDERLDHERTIQLRESWYSDTDISKGDYLHLIGTFDPSGTCVVDNAHNMIILHPDFLVSSTVVADSFSCVRKAVFQDRVKATGDISKPMVYGNILHSLFQIALEANCFSTVFLRKSIDSLLAQYVESLYMLKEPLPIATEYLRSKIHLIQEWAGLFVSKKPKANATVTEHRTRYNPIVAITKLLDVEEHVWSPMFGLKGMIDATVQATIIDHKSEKVLTIPLELKTGKSTTVMMHRAQTMLYTLLMSDRYDIDVQCGLLYYLENKEMIRVPAIRDELRGMIIGRNRLASYIRNREILPDMLKSRYTCGNCYAKETCFIYHKLLEEGTPKTSGVEDHFHDITGHLGKPHQNFFKHWDNLLSKEEKDISRFRKELWGLLSSEREALGRYCHKSRFECLYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0L4</accession>
    <name>A0A2T7A0L4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1191292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0L4"/>
    <dbReference type="STRING" id="42251.A0A2T7A0L4"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="44"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="906"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="966"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1000"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1139" mass="129934" checksum="E4D3B564E3A1E222" modified="2018-07-18" version="1">MSSEEEGNVVLSKLPETVDPMIRAHILSLCSALGGTSTVEDGGYSLGDDALACLKDLKKWLKLYDQKMNRFDVARCMAEANLVKGDLLEILGGWEEDEIEDRIKQRLALGCVELLVPLTWPFERYNEQSTVNHHRHIPVLRFAQAAYKKAILQHPSKRILSNIVRIALPSVAMPPNERTERDEGLIKLVLYFFRNLVMIEHPMVTETDTGEEISRSATIGALKEQNVLHFLLFISSKVGNEFNTQDTVTMEVIYHLVKSVDIEKMFLTDEQESQKQGQDLTTLLKLEDEMKRASIRGASTRHNRFGTTVWIERSDKTRSFVSGQGALLGKSTGLDKMDASKKWKKPRGADTKGISRKTEHDMSLTLERRAKAKLREFVEDFLDAGFNPLFSHLRRAIDRDAQRLVESNQQQYFYLIAWFLKAERIRRKTLANSEDPATADLESFSLVASVLNQESLITLNRRMTEWFDTKQWTPLQSAMRCFTQILLTVQDMVVSPLEDDQEIAENIQNRLFYEEVTLDLVVMILRSYTRQPFGWLDDCTEMVHVHLKMLERFSKQHEHMFIRSRKRARAQRKKNVTGEDGAEGVPEEEEDEELAEQSKAAMKERAFDYSRFEQKFLTQGCLDTFLAFIGNYKELNYSQMKRAITFFHRVFVKREQEILMFRIDTIELFNRILQGPDGLPNSHPARQEMDQFFKHYMRRLVKMLEKRPELYAELLFTKVNSTMHYLQFGYNKQIKVSKPREVAELRIKPGLEFSEQVSVAVGALLDENKGDAVDWLKTVLSAAISERKSWEAEEEARLALEAEAAGPDSETAPQPSPSDPPFINIKPDNEARQTALLKDAKLRLLLTTLNFEKLDATDTLDARWIIPSQLTAIDLQTSFELLKLNTDNPPTFPDGQLAEDFISRKPKPRVQAFDSDSDSGPGPLFEPGGPTPMPGAEKPKKKPAKKRRRKDTTELTELGSDLDDAAIERALKRRQKEKERLAMIKSSLFVHDSDDESDEERDKQFYEKERIQRAMGPVGLDETAGPQLDFMEYGFGGVGEDWVASVGVGGGNGRKRKNVASEQAKAKKRRAIESGSDDDDRSSADGEKSDDDDGGDDDEEEEEEEEEQPFAQPPPELDIRTPSARPRRRGPVIVSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0U3</accession>
    <name>A0A2T7A0U3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B9Z19DRAFT_1062709</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0U3"/>
    <dbReference type="STRING" id="42251.A0A2T7A0U3"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000016">
        <property type="entry name" value="Calcium-transporting P-type ATPase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0915">Sodium</keyword>
    <keyword evidence="17" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="905"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="947"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="998"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="16"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PUU81351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1096" mass="120395" checksum="4A0EA6576A2A584E" modified="2018-07-18" version="1">MASKRYRPQKPSFSRPPYQLSADEVAQELGTNIETGLSPSQAKQNLDQYGENKLEGGEGVPVWKVFIKQVSNAMILVLIIAMALSYGVKDWVEGGVITAVIFLNVTIGFFQEYRAEKTMDSLRSLSSPTAAVLRDGNLDHVASIAVVPGDIVDLKTGDVVPADLRLFEALNFETDEALLTGESLPVFKEPEPPIEGEVGVGDRTNMAFSSSTVAKGRARGIVIGTGMATEIGAIAETLKGKTKKPSRSMSRKKHGNFQPVRGGTLKAWDAIGKLLGLTVGTPLQKKLARLAYYLLLCAVILAIIVFAANKFRIPHEVVIYAISLVPDMTSGIAIIPESLIAVLTITMAVGMKTMVKRKVIVRKLDALEALGGVSNICSDKTGTLTQGKMITRKAWIPGVGIYTVDRTEEAANPTSGVVRFGEAPAATSEPIDANKTFERQQEARDQARSALALKFADGTEPRGHRGIDPGDTPDENYFQDGALPVVPELEAFLHSSALCNLATVRFDNTKRQWQATGDPTEIALQVFCHRFDYGKKKLVADGWKALQEYPFDSDIKRMSVVFQEPNNRRYFIFAKGAVERIIDLCTNVGFGDKQAPMTEEMKQEITRQMTAFADQGLRVLAIARRIMDTPPADWNEFPRDEVEQNLTLMGLAGLYDPPRLETKEAVRKCTNAGIQVHMLTGDHPSTARAIAREVGIIPADFGTLPADVARSMVKTAAEFDALTNEEIDQLPALPFVIARCAPNTKVRMIDALHRRGRYAAMTGDGVNDSPSLKRADVGIAMGLAGSDVAKSASDIVLTDDNFESIVNAVEEGRRMFDNIQKFILHLLVSNVGEVILLIIGLAFRDRDNFSVFPLAPLEILWINMLTSSFPAFGLGLEKATSDIMRRPPHDTKVGVFTKQILVDMVVYGTIMGACSLCTFVIIVYGVGNGNLGVNCNSRYSSECDLVFKARAAVFAQLTWLILISAWEFKSIRRSMFRFDPYQTEHRFPFPRDVYQNKFLFYAVVIGAVSVFPVVYIPGLNTGVFKHKGITWEWALSFGAIPVFVCGVEAWKFIKRKYGLFNNRESDRVKKDASLSLRQGFFTLAKTTTRASSAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1I7</accession>
    <name>A0A2T7A1I7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1I7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="63" mass="6932" checksum="43EAB72BC5273619" modified="2018-07-18" version="1">MISLNSDGGRRSLFLSRDKNIIPASRCYCCCCAVPYTYSTGTPQSMVRDAVLTITPTLHFIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A219</accession>
    <name>A0A2T7A219_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1062361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A219"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="190" mass="21338" checksum="0A111B33077A29AA" modified="2018-07-18" version="1">MSQNIQTIASQECIISLHLAESTSISGMDAAKEILASIRALSKYMDDCFDQLPSRDEHGHHFAQLPSRDELGHHFAQLPSRDELGHHFDDLRGQFQHFNTHLAELRAEARDQFVGVSGKFTEVLDRFVKIDEISAEIREGFGKADLQFEKVGEGFGKVDQLFAKVNQDFPIVAQLRPSIKTQTATELTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2Q7</accession>
    <name>A0A2T7A2Q7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1099467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU82009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2Q7"/>
    <dbReference type="STRING" id="42251.A0A2T7A2Q7"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="160"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="578"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="719" mass="80395" checksum="6EAAF76DB6FDC385" modified="2018-07-18" version="1">MPRPAVSGYERLAQEAQLSDSDDDDRESIVDHPSRVVTVQPRPPTSMLSTPYGPVTPSHNGRPVKRLRSNSSGVDIKAINARLERWSHEIANKFKFKKGRSQQEHPPLEIVYSVFVPPEGTRPLTDASPLGLPPVAENIQFTQEQFDEIVESVRLAIRKGIDPKLIKQGSSGSYFMRDSDGNVVGVFKPKDEEPYGKLNPKMMKWLHRTLFPCFFGRACLIPNLSYISEAAACLLDRQLKTFLVPYTDVVKLSSKSFHYDYWDRRAYYKKHKPLPSKVGSFQVFLKGFQGLRRTPWASACRPSGAIDDDSDEESHTPLSMDDPENRRFVWTEQLQQNFREELEKLVILDYIMRNTDRGLDNWMIKEPMVASSRSETPQPGAGATVTIGAIDNSLAFPWKHPDQWRSFPFGWLFLPVSLIGQPFSQKTRDHFLPILTSAKWWAETQTLLRRLFEQDSDFKERMFQRQIAVLKGQAFNVVETLKTPDQGPLELTRRTRVHVWDDEMEVPVAVPLRVPTASDTRRRREHDVEQGFNEQAEMDIGAAASSAPLPREIDILGLGLSPPRYEIPSSVRLGISRTTSIGSSNGGELSDQQSALIPGSPQSTAETAVPKSPTGRSGIRGGGAPSSPRPQRLNHKSFDASGGGGSPRKKDAPGLLDPRRRRFSLTGGLGGPPRNVYNDDDAEGDLGYSAVGGSEGAQRKVIVERLEAVKSRNPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2W2</accession>
    <name>A0A2T7A2W2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_969540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2W2"/>
    <dbReference type="STRING" id="42251.A0A2T7A2W2"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU82054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="453" mass="50262" checksum="16E05A34ACE5820E" modified="2018-07-18" version="1">MMDFLEFWGTPILFVSLSFSLFLLCLPSRHVPPKKDEKPRVVVVVLGDIGRSPRMQYHALSIARKGGLVDLVGYDESSPRPELVDNSKIKMCPLPPPPGFLRTDTPIRFILFAPLKALFQLTSMLYLLCYIIPPSAGYILLQNPPAIPTLAVTKLVGALRGMKIVIDWHNFGWSVLQLKLKEHPIVYFCKIYEMFIGRGAYTNFTVTDLMGLTLKNDWGVKTPIKTLYDRPPTHFTPLSPEERSKFLESHPATAQHASSIASGATRLLISSTSWTPDEDFSHLLGALLIYDRWASGANFLKRGSAPSILAIITGKGQLRDGYMARVEALEFQHVTIESVWLESKDYPKMVGCADLGVSLHTSTSGVDLPMKVVDLFGAGVPVAAFEYLAISELVKDGVNGIVFKTGEELGDALVNLFNPASQRLKKLREGALEETENRWDENWDKVAAPVFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3K3</accession>
    <name>A0A2T7A3K3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1061970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3K3"/>
    <dbReference type="STRING" id="42251.A0A2T7A3K3"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="699"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="821" mass="92260" checksum="9681F2487C3FB60D" modified="2018-07-18" version="1">MSYLGNDRYTGGDRDRDRSRGSRDRATLESDYGRLNDAEWGYGRGRGRSPGLISAGPMRRLPPRRSRSPPVGGNIDRYVPRSPQPRRSRSPSRSRFEYAQHGVPQLPMVGKPGAIDRYVPPHNGTAPPMYFDPHRLDYQVTFNYFSDWYHQENPGGAGPNMKEEVKQKYDEYKDELTARLAKLFVTTHKNDEWFKERYVPGEKEVTKAKIVEYRRGAFERWRVQMQSGTLDNIDRETGTGTAPKSEDNALEPGEEIEEINRTLEDGGLKPVLLIKTISPTVSRAQLEELASTNLSNFHYISLSDPNPLKKFHRIGFILLSPTDPSDPTSEPASVDESIVELLNGKSIHDEIHGDFVCHVGIHNGPTSARTKKVLNEAMSLPENLKKEAKLVEKCIKKLEAELHRDGDDSMVEYDGWEMIKDKVEEWGRGEREKRMGSEEEGEESGESEVELKITKKTVDMGVEYLRRVFSFCIYCVSSSDSIVELTRKCPGGHMRRPTPASDFAPDNRTVNWTKAWQDKLEFFVSPPQPHDEDYKERLRKVGGKPVPEAVEDEVQRSMKQEDEGKYRCKVAGCTKLFKAEEFWRKHLDKKHGEWLQLLETEAQLVNSYVLDPCRVHPPKIEQNNQGGFQTVQTGGNRGFAPMMSLSTFGGPAPRLELSNHLPDSTSMHHSSRDTTVTVRINTCRIILCQLLGLASRTPAERRRENRMPPMGAAGLPMAVGTGRERFAPYNARGGRGDRERERERRDREMRELTRQPGNAPANRVSGPVGGGTPSAAPASTSSGTSGGGEAELAVLGRSVKSYMDLDAAGGEGKKSVEELDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A409</accession>
    <name>A0A2T7A409_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_415425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A409"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015518671" evidence="2">
        <location>
            <begin position="19"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="72" mass="8412" checksum="F55F8038888CD592" modified="2018-07-18" version="1">MCIFFLFLLASLSNLAPCIIHSSLSSLSTFLFLFLTALQFFSYKWSISFFLYCPLFLYSTRQRGRFLLIAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A435</accession>
    <name>A0A2T7A435_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000027">
        <property type="protein sequence ID" value="PUU82484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A435"/>
    <dbReference type="OrthoDB" id="4638065at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="201" mass="23018" checksum="9070922DBD743748" modified="2018-07-18" version="1">MKQEAEAAQMNGQCTFGHIFGSNCTRVEVFFQIDSYGEPATPTSRKATLADTQALGSSFEQIDIGDKGFYMGLDKNYEKIFVMFGAELKFIYGDKIGDYVEKAMIWNIKKYLSVNPQSIPKDTRHKDYAEWLLSNPHLCHMKKALLPLFKAMVAITRAQRILLAAVDLECLQEYEKILRKCLDHRISFETDEGECFTLRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Q7</accession>
    <name>A0A2T7A4Q7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1074261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Q7"/>
    <dbReference type="STRING" id="42251.A0A2T7A4Q7"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="32590" checksum="02BD13408573B557" modified="2018-07-18" version="1">MPCPAENALEGLLSTYHELNNAFVPRVPGPPTPLEFLQYVRRNQPVVFTGLMEGWGALERWDDRYLRERMQGCSIDVAVTPLGNADSIVNVDGVEHFVKPYTSSEPFSSFMDYLRSRHMNASSTPPSTIKYAQSQDGNLSKEFAALAPDLPPSLAFADSALLSAPDAVNVWIGNSDSTSALHKDNYENLYCQVLGKKKFVLLSPLEGICVREKSLPVASYDPQGKIIKEEGHSINGWPSVDPDVGESGKWWGKARPMRVELHRGEVLYLPALWYHKVSQEEGDEGICCAVNYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A552</accession>
    <name>A0A2T7A552_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1119975</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A552"/>
    <dbReference type="STRING" id="42251.A0A2T7A552"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU82877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32638" checksum="8B663A7784A6A900" modified="2018-07-18" version="1">MELAVKFFLLLAILLYLLLKLTAYLLITYQNRIFAKSHNCLPPGRLPSSFVGLSNWVRLTRTAKRGDILDHILSHFPIHGNTWKGRVLFSTSIGTIGPENIKAILATSFKDFGLGSQRHNNFYPLLGDGIFTLDGAGDVEALELHVQRLMNRLLEGDGEVADLQPLFYCLTLDSATDFLLGESVDSLLSPELNPTGAASGGKEEMSFAQSFNRFRDANAIVHGLIDRYVDMALHPEKRAKKAPEGKYAFLDAIAAETRDPGYLRDQPRVMKEGETRMGRHRVLLLVHTPVFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5H5</accession>
    <name>A0A2T7A5H5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1016527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU82989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5H5"/>
    <dbReference type="OrthoDB" id="5383427at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="294" mass="33382" checksum="DE76078E54FF310D" modified="2018-07-18" version="1">MTSVQGIYQQTYFITRDFEDLMDISPLSSEDPELVPILDREDNSDLSRPDSSISSYSSRSSTDSLCVLDLSFPYIQTPQKYQLPPPPPPTPFMTSPLVSPLKHGLEDDRDLYSSPFVLSANLLELGETLGDLFVESDREYRDIGESAYIPFQNKQKHLPESWSLPCSFSDPTNYPSLNVEAYDNEDYCIPVRSSFDEGRFMTRKAPGVYPANRTNNPIPRTPPPSRCSGDSEERPWSLSEIEKQLQLLADEQARAEESQAQDELAELGRPTRRSHRGGAMKKFSRAWRGYLHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5U6</accession>
    <name>A0A2T7A5U6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5U6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="16956" checksum="A7B7E282F1A7902C" modified="2018-07-18" version="1">MRSLFFPLGNEVHGKKETTEKEKRTSGSQKIKRKKGIEENEQLHLCFLGTGMALYDGSNPVKGKPTWEKHGARYRILQLILTYYHLTVKGTEQSIWPRIDAGTEMRCDLGVVWPSYLVFSCFGLGYISHVTITTINLDKRFSSPSTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A680</accession>
    <name>A0A2T7A680_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_965284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A680"/>
    <dbReference type="STRING" id="42251.A0A2T7A680"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="306" mass="34223" checksum="BFE3E34EB74EB3B4" modified="2018-07-18" version="1">MLSRTPRLLLRRPYILVPVFKQVTTPLSSASTAKYSSKGSPTDTPDPAPKPDKPTRSYDDIQKSKPLSPALPKTFSANASDTLRKVGFANPPPELLSSATEIAKETNLRERNDLGPGLAGSFGDSIPELFVGELASSAEFRIEPLRRTGEDLSTKRARLLYQSRKRGILETDLLLSTFADENLGKMSMEQLDVYDRFLDENDWDIYYWATQMPPATSTECAQRASKEVTSGSVKRKKVDGKVEYGQGEWAQTVGRKKEPYRPPPKRWAGSEMLEMLRRHVKEKSGDADGVRNIRKGLGRMPDVRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6P0</accession>
    <name>A0A2T7A6P0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6P0"/>
    <dbReference type="OrthoDB" id="10508042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="21067" checksum="DF0F4926E4B08835" modified="2018-07-18" version="1">MENSKAARRGCAATRQHPKSSQSPRTSRGRGNIPSHTGSTATATATTDPGPSKTPRRDRAKRYAPYPAPRKKTPVRGKVPKTPREDRAKYSAPYTRPQEKTPTRNKASEHRVGGRSGRLKDGASSTIEAFHAGLEEEEEGGYDGDDEDGWNFMEGDSSSMRRRIKRFCWGGRVFLGRKLDRVGKFLNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A776</accession>
    <name>A0A2T7A776_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vesicle coat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_963040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A776"/>
    <dbReference type="STRING" id="42251.A0A2T7A776"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="108"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="410" mass="43960" checksum="B14689ED00F598DD" modified="2018-07-18" version="1">MTDTCRSCSMTLPSRLNEKLSAPSLASSPLGGGKSPAATKSNNPILRTKEVIISSAPFLSSEDEDEASEGQLPSYIRRRRATIDPEHLSSSPNARSYFNSTPASDDEAAGGKSSVGSSPHVHHITYLSTRAPSVPSRYSTLRQSCVRTLSCELIPAQTGPIMFGDPLAGYTIAYVFRLADSKARGERRSYALVCICPDQKIVVKSWKYVVAAFEALVHRIKLLAAKKAAEDAQVSPALSNSISSITSRGPDGFLRRRAPGECGGQKGLAELVGREELFVEVHMCFVKLLGGLVRRYGCWAGSELGLSIGTGSSFVTPVMDRSRAGSVSSSVGDEKLEKKTVTSQTVVEGIEMTRSERAANGTKVTFPPTTAGLSVHDTITSRATSSTPRAPTAKREESTHQRSRNVILIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7T8</accession>
    <name>A0A2T7A7T8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_962608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7T8"/>
    <dbReference type="STRING" id="42251.A0A2T7A7T8"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="34"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="206"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU83775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="370" mass="41252" checksum="898868D676AF22D0" modified="2018-07-18" version="1" fragment="single">KIFSTLYSPEPLLRALALLNFRWPSRIQARAIPILLRDPPRNLLGQSQSGTGKTATFVITMLTRIDFTKSFTQGLVLAPTRELARQIMDVIQALGQYMGVKTQFAIPAMFVKGREFDAHIVVGTPGTTLDCVRKGQLDLDHLKMLVVDEADNMLDLQGLGEQCIRIKSKRYAPDCLTMTLEHHELTVAGIKQMYMDCLNAEAKFGVLVQLYHVLTIGSSIIFVHRREDANRIAERMATEGHKISVLHSALENGGVARDKVIDDFRTGHTKVLITTNVLARGIDVSTVSMVVNYDLPMDKDGKIDFPTYLHRIGRTGRFGRIGVSISFVHDTVSWMQLMQVSDHFGVSISKVPTGDVEVGSHFIRCDIFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8R9</accession>
    <name>A0A2T7A8R9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_961714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8R9"/>
    <dbReference type="OrthoDB" id="5362457at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="261" mass="29176" checksum="EF18EBAC3B752FA2" modified="2018-07-18" version="1">MGNGMSISTFTSSLRGAMSSAGAPKPTKPAIKKKDICSEAGAKLKKFVRFLDRVEIVPAAPFLMFDEPSNKKQKTSEAFNDPAITAGLGRAGSPNRSPNRSPNRSPNMSPNNSFKHLPSTNTDNHLSPPEELYFYHPPSPPPSWRIPPSSLTGPQPHVVTPPRVRSPSRPGEEIDLMARDNHRDSGVYMDSSEDEDEIRPVIARKMWHGEVRFEDQWGRRLIPVERKDAFRFDLWPVEEDVDNEVGDGSGWVGRFRGMSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A959</accession>
    <name>A0A2T7A959_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1037609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A959"/>
    <dbReference type="STRING" id="42251.A0A2T7A959"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41289" checksum="D90B7E7048940FF3" modified="2018-07-18" version="1">MPIPVENVGSLPRPLALQKTLAAYDDGEASHDQLVKAQDEACKDSIIRMEAVGQTCVTDGEQRASSFATYPLADTLGGSGLAENLAFDGQYFAFFEDGHNRQLPRLTGGPFRYKNYAADFMELSKPFSTLPLKQAVIAPSMLYLLYPLEGSIEGYTREQFLNDLVNECEKDIRKCFEAGAVRVSIDFTEGRLALKNDPTNPWTSHGLLDTFININNRVLARFSEEERKNIGIHTCPGGDCDSVHSMDVDYTDLFPSLFKLNAGYFLVQCASEPDKEKVYKLCGQYSRDDQVVFIGVINPLHPSLETAEEVCEALVTAAKHIPKHRLGAADDCGFSPFSVDVKPKHGGPDIARDIAFKKMKARCDGAKMASAKLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A983</accession>
    <name>A0A2T7A983_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B9Z19DRAFT_279086</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 15">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A983"/>
    <dbReference type="STRING" id="42251.A0A2T7A983"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="152"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="303"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="591"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="653"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="698"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="742"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PUU84289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="779" mass="86760" checksum="89571C22B2EDCC7E" modified="2018-07-18" version="1">MNCQHVSTARLTPPRANQAVHREDCTQCFDGIDDPEGLNVCLSCFNGGCAGERNHALLHHKLSQHPLTLNIRRAKKPRVERAEPPKKISKLAIEAESENDKYDTYTAIICYMCGGKEVERTVGNLPEVVDGVMNAMTFSRQTEVQAWEQEMTPCEHTLCLQQEAPRKLESQNLATCSACDLQENLWLCLQCGNLGCGRAQFGGVGGSSHGLAHFDATHHPVSVKLGSITPEGTADVYCYVCNDEKTDTELAAHLAHWGINIAEREKTEKSLTEMQIEHNMKWEFSMTGEDGKELKPLVGKGLTGLKNLGNSCYLASILQCLFALPSFQKRYNLPDLPESLVPADDLETQLRKLADGLLSGRYARPDTDVAVNEYSPETPYQRGLAPAMFKALIGKGHEEFSTMRQQDAFELLLHLFKLISRSPHPGDLEDPVSDFRFALEQRLQCMGCSKVRYRTDIQDNISVPVPVRRIPTESSDVEMKEGDKEKDKNKDFFEPVTIKECLDIFTADEIVGFNCPSCGKDAKATKRHAFKTLPEVLAVNARRFEYINWVPTKIDVPVVVGDEPFLLDDYLAKPRPAHEELLPEDEDPRFQADEGIVSQLEAMGFPRMRAEKALYHTGNKDPEAAMNWLFAHMDDPDIDAPISFASKESAGAEPDEEKVSMLGAMGFTAGQAKKALKETGGDVERAVEWLFSHPDDMGDDEVMGESVNTDTPTKEPGRDERPAQYELHSIVCHKGGSIHAGHYVAFIRKEVEGEGKVWVLFNDEKVVKASDVGEMKKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA26</accession>
    <name>A0A2T6ZA26_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000568">
        <property type="protein sequence ID" value="PUU72335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA26"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="17075" checksum="70DCFC69626759AE" modified="2018-07-18" version="1">MVRAFALPLLAESFNDRRSMDAIRKIVLSVVKLSDPRWILGQFGTRFRALPGILRILLVEGHIETLALTHELCLEDLISELQAGEKFGSVTKFNSLTNTVLDNIASIAGKLADPKGISGEEAVVVDHFLTPGFILERSGTGKMTYIVYKLVERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAB0</accession>
    <name>A0A2T6ZAB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1097417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000561">
        <property type="protein sequence ID" value="PUU72364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAB0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="9076" checksum="267E7CE938766010" modified="2018-07-18" version="1">MRWRTGVYYEVAFSPLFGVAFFFCSCLLFAPLLYDHGDGTIYDRYGKFDEKMDGWMDGLVVMVQKLISNMYSRNFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCA8</accession>
    <name>A0A2T6ZCA8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1095788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000413">
        <property type="protein sequence ID" value="PUU73099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCA8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCA8"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="323"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="586"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="621" mass="67164" checksum="D64BD0D8EE569942" modified="2018-07-18" version="1">MPITRKTIYAAQPSTQRARPAHLSTDPNGERLAYASGKSIFLRSIDDPSLSTQYTGHTSTANVARFSPSGYYVASGDSSGMVRVWDAVGPEMITKGEFGILSGPINDIAWDGESKRLIAVGNGKERFGHCVTFDTGNSVGEILGHSSAINSVSIRQSRPYRAATASDDHNVVFFHGTPFKYNKTLTSHHSNFVQGVAFSPDGEHFVSVGTDRKIILYDGKTGEFKTEIAYGDAAHRGGIYSVSWSKDSKRFVTASADQTVKVWDLQSEKNSHTWRSGPEGTSIPDHQVGVVWTPRADNTIISLSLSGDLNYLDLNSDRPKRVITGHQKSIGAITVTGETKTLFTGGVDGKTCGWDLAKGTADSLDGAGHTNSVCGFSPQDERRLASIGLDDFIRLIDVGAKVFIGTNHHCDAQPKGFTWLTLKGEQFLVTATEKGILLGKVTTKLKVNEVLQQSYTPTHISGCRDKGIFAVSATDQTIHIYSTYVEGPGEQRIREEKVLKDAQAAPTCLSYSPSGRYLAVGFSSGKIILYDVDEDYAVNTTRWSFHTARVASITWNAEETHVVSGSLDTNIYIYSVATPGKNQSVKNAHMGGVTAVDWEGSDGIVSAGADGTIKRWEVKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCE8</accession>
    <name>A0A2T6ZCE8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_574987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCE8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015539060" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15057" checksum="8CC65A98A3B63806" modified="2018-07-18" version="1">MQQWSLVRALTQLAFVANALVVAAVEGRALDEAHYKNAPGCLIECLGEWGVLEYPMCTPKKHYSDNTFNLRDFFRERRVASCFCGDSEVLASIGECVYSNVSFFSREFFAWWLWKFELIGFYSAGRKKCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCG8</accession>
    <name>A0A2T6ZCG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000405">
        <property type="protein sequence ID" value="PUU73188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCG8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCG8"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="583" mass="62718" checksum="FA2B95E0D3AC8728" modified="2018-07-18" version="1">MSGGTQPRSTISSNVSTVYEDLVPAPSPAVLRKSPRTKTAYHLAQPPPSAHLLHRHSLKPSRNLVVQLQRLSNTTRPVPTLDVLPASIFASRLKATCGRFFKHGVGSQDLVFLTSEEYGSGDEDDDDVDEDGSNGLNARQVVATVSQNYKKVPLAAGEDGKGGSGGMARVPAIRLDSGPPWEVTQTAFGGYEFSAYQEDGNVVTARWNPRGVGTTARRRSSQTQSSNSEDSAAERKFQFTLVNPDSRRHPIIATLVKQTIEINDHYPAASLSSPVTTPTHSRSSSPVHDAPSSPVSEERLYIKTSDYIRMLILASGIWVALREGLASSNGFPLNDAAPLSPTFSSTGRLSPSPATTAFPTAAANRPRTENRSSSYPAGPEISFDETPHSRLIRSGTTSTKHTPVPGDHHAQTPTPPRRSFSTGTPTRPRSTTTSHILRSLSSTSRTPSPTPRADKTNPTTRPQTPPAPLHRVPDQPLTPPTSGCMRRPRRGAHHKHTNSVSLPGSPAKHPEEKRRRNSRKGRVSKDLALVDVHQEWKGRGDGAQGDGANGLAVEGSAGVPGGKKRGKIRGFMDMLKRVTGSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCH7</accession>
    <name>A0A2T6ZCH7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1005609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000403">
        <property type="protein sequence ID" value="PUU73201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCH7"/>
    <dbReference type="OrthoDB" id="5400327at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF5">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="171"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="512" mass="56473" checksum="F93FC18726B7F6DB" modified="2018-07-18" version="1">MPTFKHVTLNIHTPQEPPISTENFSWANTAHSPLPEYGNHRLRNTDKITSYIPSTTNSPFAISITILDSYQPKNEGDERESLAAYVYFDGRQKEETATLLRRGVETWISSRWVEVKEGELAEREFVFKEVGLESFLSGLDLSKSDREKNAKNGTRKGVNRRHSMPAKMKANTDDDDEEDADVGKKESVGQIRVDLFRVRCEGPVRRGVWGGMFKDARGDEDDEFGGGVDVSHTAGLSDPKPLDRETVSTQSVSHLDPEGVVYASFVFLYRGERQLKKMGLIKPPAPIRADSLSAAPSKSKKQDFTTVASALESLIAKGPEKNGASKRFNDFRDGHNGATNGDDLKRKNGKKIPGLDGRDDEVESLVGDEFARDERDNLRERMRSEEDVRLEEELVGGVDRIKLKRSHSTSSLRDSGSKDKASTPPPDLSTNGKAKTFPTPGEDTIKKPEPAHANGHEPETPLKKRRGSGDVDVKSPARGLGFGMQATPMTGFGGKVEFGGMLGGMEVEEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCL1</accession>
    <name>A0A2T6ZCL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000398">
        <property type="protein sequence ID" value="PUU73232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCL1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="13903" checksum="4EF6D75C2643DCCD" modified="2018-07-18" version="1">MNATLRFLIPLSLLLFLRLSCSTLLPLLLLSRSPASASLPLLLFLCFSSPAAFPCFSYPAALLPLLISHSPSFTSLLLLRLLSLPSQLLFLSSLSCFSSFASVSCSSSYSFLLSLLFCFFSLTISSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCS2</accession>
    <name>A0A2T6ZCS2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_552952</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000391">
        <property type="protein sequence ID" value="PUU73290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCS2"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000655">
        <property type="entry name" value="Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="20">
        <location>
            <begin position="336"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="821"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1366"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="459"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="573"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="662"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="755"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1579"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="591"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1612"/>
            <end position="1624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU73290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1688" mass="189902" checksum="22BFE718B904408B" modified="2018-07-18" version="1">MRSNTRKRPGPSGSPENGHTTPEPQASAPNLEGGSGIKKPPSKKRKLDNSPPWKSATTQTPTSFVGEDGRRKSGRTNPIPPELQPFLKNGTTPTRPTRSSQRQSEQKKNALLASAPVANGSRSRSSATQNKSSGRARPTTPTPKISGRNSRISPKRPPAPKGTPIKKSTPAKSASVQKSAPKTTPAKSSAPPKKSPVAGTRKSARTAGRNALTEEEIINGVGIKPESATTGRNGFDRGFEFESDGELDVDPDFRAPKIKLKFSIPKPVITHPSHVPAQREFDSFEDFLDHDDIFKNPALLAAAEEEAREEAAIRNKIEDAVVNGLLRPDQCSLYLPEKVPEPPQPYSHQDHLVAHALYLQRLLVKERKEHIEIMKKRNALIMAEIKRRRPLTKEEIEQEEFLENRRIYREQISQLRRKWEEVLKEVENRRRMRAEEEHRLAGKQHLNQMLEHSTQLLEARRGDRHNSATASEDGLDMLEGEEEEGEYDGEDDGEEEEEDDGRVSELEEELDEANMSTTDSDEEDVEDDDENLTVEQLKAKYAGLGPNRASLGGKGLIQEDDLSDIEDGMSLDSRTSVLSDIPSDNAARTDVDEDPTEAVELEEVDDILMDDSDESVDMDSESESDGNEGGEDNSEDDSEIENAFGSGLLGLYGDLSGLRANVRDLEPESEDENELAEPVQEGRSLEKSSDSVQIESLSKDSKVNATDELLEEDKIDEVSLVVYKSPPGKDVGANYLSAPGVIGGQALEMPMLNGHSDTMDAETSTSLSHSQVDLKESGHPSSLTTSPETSPQPNIDIKTPIPFLLRGTLREYQHYGLDWLAGLYDNHTNGILADEMGLGKTIQTIALLAHLACEKGVWGPHLIVVPTSVMLNWEMEFKKWAPGFKILTYYGSREQRLEKRKGWFDNNLWHVCITSYQLVLQDQVTFKRRNWHYLILDEAHNIKNFRSQRWQTLLNFKAEARLLITGTPLQNNLIELWSLLYFLMPSGASSAMPAGFANLKEFQEWFAHPVDQLIEGGREGMDDEAKHTVTKLHRVLRPYLLRRLKADVEKQMPAKFEHIVYCRLSKRQRYLYEEFMSMAKTRETLASGNYLSIINCLMQLRKVCNHPDLFETRQIVTSFAMQKSAVADYEVKELLVRRRLLKEDPFKPFFSTNFLEFCGLVPAKSNHLSTQHSDEISRLTATEFLQKYYKDRAADIKPVEPDFSTVRGHAAYLKHQAEVSHLETLQSCVRLNRSRTQYRPLFGKNLVELCTDGVSVGPSKPMPKNRKLITDWFLNRSEVISSMILTLEDRTESMGSVIDKFGCITPAVVATDMAPIALSPQGVELIQEIQVENLFPSDPFHKARVRLSIAFPDKRLLQYDCGKLQRLDLLLRQLQTGGHRALIFTQMTKVLDILEQFLNIHGHRYLRLDGATKVEQRQILTDRFNNDTRILVFILSTRSGGLGINLTGADTVIFYDLDWNPAMDKQCQDRCHRIGQTRDVHIYRFVSEYTIESNILRKSNQKRMLDDVVIQEGDFTTDYFNKLTIRDMLGDEVIKDLDGVDDSQTVVAPGVNMEKALEAAEDVEDVAAAKVAQKEVVDADGADFAERSTPAQTPREPGTATAGTTPREPSAPVSNAAMTPQRNTVEPEVVTHRGLGYDIYGDGWNRVDREPVHIDEYMIRYMEWELVDVPLVLPNKSKKKKSKKGKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCY9</accession>
    <name>A0A2T6ZCY9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_547015</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000385">
        <property type="protein sequence ID" value="PUU73360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCY9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCY9"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="87"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU73360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="363" mass="40025" checksum="E89F1568607281DD" modified="2018-07-18" version="1">MGQNAPLVLLVSSLQNTPITVVLCGFLGLLGFGILTSYILILLVAHTPRRETNSERAYRTIAKDGKTTSTLPLPDTYSSEKEEVILSVVVPAFNESERLPVMLAEAVTFLHDEYGLNKKRTNGGANDSSVTAGWEILIVDDGSTDNTADVALDWARSRIHTGEFTEGDIRVCVLEKNRGKGGAVAHGMRHVRGKYAIFADADGASKFSDAKSLLQELRSVEDDGFGIAVGSRAHMVTTDAVVKRSFIRNFLMHSFHTLLKTLGIRHIHDTQCGFKLFSRAAIKDIFPFMHTEGWIFDIEILLLAGYLGVPVVEVPITWHEVSGTKVRLVQDSIRMTWDLGVVRLGYIWGVYRVGLGGPSKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD03</accession>
    <name>A0A2T6ZD03_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000388">
        <property type="protein sequence ID" value="PUU73326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD03"/>
    <dbReference type="OrthoDB" id="5487439at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="23774" checksum="BDC6B49FCA7FFC26" modified="2018-07-18" version="1">MPPSGLTSPCSIRLWLDQASIVRLDDPLPSRLDKIQWQTYEHVYYMEMTEHTMDNLFSCINRVLSCGYGYRLLVGTTRQGMCILLDDPKEPLPLAEIITLRNSRHVHIQWSVNSLSELMDLLFYSHRVHDQDRTPSPGAIYFDPRDNRGPSPNALADDNGLDGDGNQLGPSAVATKKVIQHRASLGFQFHTISWHSCLKVWSRNRKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD10</accession>
    <name>A0A2T6ZD10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab-GTPase-TBC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1004571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000381">
        <property type="protein sequence ID" value="PUU73380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD10"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD10"/>
    <dbReference type="OrthoDB" id="10263206at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="129"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="380" mass="42494" checksum="FBD16D3195B61CA3" modified="2018-07-18" version="1">MLNPTGPGLRRVKKFPSSSVLESEYHNSATSPVVLSTTQSASQSLANVTNHPLVPKRPRSQSQSQFDGPKYPVNNNQRYARKAISSAQLVPKQKATIEGLISRPPANLIEALQDLRYLILTEGIQADNDGNSPLRIYIWSILLGVSPMRTSDYVSLVRRGASSSYSKIRNDTFRTLATDPLFRRRVSEASLIRLLNAFQWKMRDSGIDAQYVQGMNVIAAPFLYAARSEVEAFSLFSVFIQRECPGYVKPTMEGVHRGLKLVDQCLEIVDPKLYAHLQSKFLSAELYAFPSVLTLSACTPPLPEVLKLWDFLLAYGAHLNILCVVAQLLLMRDELLVAQSPMKLLRQFPPLNAKMVISVAVSLVRKIPEELFEELVNHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDP5</accession>
    <name>A0A2T6ZDP5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING-14 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1134886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDP5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDP5"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF51">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR OF YEAST FORM ADHERENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="6">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="336"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="430" mass="48839" checksum="3F9D9C1678FAB507" modified="2018-07-18" version="1">MKFAHSFSQVLEEEDFPADWRAAAIRYRELKKCIRRVQSELLDLGLTVEVLKGLVEEAEGPVFKYMFDGTVHSFQPKLVLTFDAVNGIPLDLNLSQDTRRSLENLVKKELGKEEMEAKSLAVKDGTEICGSIRVVEIALNSDSEFFHLLTSEITSLEALQSKSESEIRSHVLQLGQSITAVAAPKPRNSKSDLYPWREIFRIYLESGIFFSNLESESHQERTVEKAAERLTFFTDEVRRLGIQTKFKNPYSPSLFKMFLSVNMDVLRVMRFHDINRTAMTKILKKFDKRTALGACQTFPVFVAPTGPLTSHLSRAICHTLCTSLLNVIPQLDDYLCPICSSISVKPVRLSCSHIFCVRCLVKLQRANKDSCPMCRRNCVLGADAGNLDIGLYNFLKEYFPKEAKIKQAENEREVAVEHWKNIHSESCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDQ2</accession>
    <name>A0A2T6ZDQ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000369">
        <property type="protein sequence ID" value="PUU73534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDQ2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="296" mass="32528" checksum="58729F563B2F0300" modified="2018-07-18" version="1">MHHTQFSKHHGRGDESTSSNETQVFATGTCRAQILSLRTILQVPVYPFYQERYGILLATATARQHPVHTGGLSSVDFKGPIDRGMLCTQAGDPRIMNPSATIKNGGEESNATAKHDAAAKTRIIEVITLAGTPPWNTACAQYRTRALERELQRPGGIVNDGTRVRITVFKVQYSSAGTARVPHPRGQYSSTRVHTGNSNQQSGEREPDSLPTFCFLHETTRKNEGYQPNAKKDGGCSEALDPQICDCTFLFARFWVVCWSQPSAGLPFAPSLSQLNGNDDQIPGHTVTLMQYRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE40</accession>
    <name>A0A2T6ZE40_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE40"/>
    <dbReference type="OrthoDB" id="10420621at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="12941" checksum="C5BE6C599C0FD418" modified="2018-07-18" version="1">MASTFKPIVREFAAPIAIVFCGSAIFGLNVLNRFDHTKNTVKLDNTYEQLQKATTELSVRLDTTNKEIQSIRHGLKNMNTQIRIIRDDIRLAQLIAGSAILVKVDGLKESTPEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE50</accession>
    <name>A0A2T6ZE50_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE50"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="15142" checksum="DB724F983D168E85" modified="2018-07-18" version="1">MKLGKEWIDNKTNKLRATRDQLPAGSIDLIAGNFLMNDWFAEIGGFDQAILVFLTSPVVHTSPVAHSSALSLTPTIAESPTANSTTTIPATPDSPGTDASRIRRALEAQGQRVGFQLEKREVGNGAEIGRIWMWNEPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE87</accession>
    <name>A0A2T6ZE87_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1002997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000345">
        <property type="protein sequence ID" value="PUU73803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE87"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE87"/>
    <dbReference type="OrthoDB" id="7362584at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34147:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 WD40 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34147">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="11519" checksum="97E65CA0BC4799EE" modified="2018-07-18" version="1" fragment="single">GQQGTAGDSRGQQGTAGDSRGQQGTAGDSRGQQGTAWDSMGQHGTAWDSMGQHGTAWDSMGQHGTAWDSMGQHGTAWDSMGQHGTAWDSMGQHGTAWDSMGQHGTAEDGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEL9</accession>
    <name>A0A2T6ZEL9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1160946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000331">
        <property type="protein sequence ID" value="PUU73947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEL9"/>
    <dbReference type="OrthoDB" id="5489783at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19623" checksum="FEC05AF142380A58" modified="2018-07-18" version="1">MAAVLAAKVGEPPTSLPTGPAIGIYPTITETWSLPTSSLASAPLSPQLSPPQDMKYYLTEGLKSVEHQQYRDSESCLGALDSQVKKLRSDKAGQYLVFALVTQDQLVMIERIRHTHYNGVRFHYFNREETLIVKIFAGPVQAEALGRVSKSELLIGFLFLYRSRLLRRPCYNGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZER0</accession>
    <name>A0A2T6ZER0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000329">
        <property type="protein sequence ID" value="PUU73988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZER0"/>
    <dbReference type="OrthoDB" id="5507159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="319" mass="34230" checksum="E48CA284DCACC469" modified="2018-07-18" version="1">MVKKGSSHFSASSIARSGVVLSRSVEISFALEAEVSRLRHHVSVLSHRLHFCENERDSLQESAVGSPRSDSPFTGVDSDSPPPPSEVVACAHTPLVVRLPSLGGEAGDLVAASAPVAASMASSVVSSGMLVLSYSNGKLGNVRRKRRSPKRGSVIGEVDDDDDLIMGSAEPRSEIYRQNVLCRDREAERDRLDTPPPGSLGILAPGRDSEFVWWGVRRLQLEEGPLAVSVHMCPVRFGGVKGIIVRCQCRAEFERKRLGTHLQGVLRKGVRVEECPEGRVIKEGGRFVAARDVDLNCLVEGCPVGGASFTGMARALIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFC6</accession>
    <name>A0A2T6ZFC6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000317">
        <property type="protein sequence ID" value="PUU74183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFC6"/>
    <dbReference type="OrthoDB" id="5502633at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015457381" evidence="1">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="27546" checksum="F956F5CC27DB3B68" modified="2018-07-18" version="1">MWTYLLSTLLLLQSIAVQAQLPPRAKNGLFTQIACDSITQTRQNQLALFDGDHKPLPNGVVFESCSLISGPCKIEGFSNVTVGPYTVVHPNAIFGPCQYTDVPMEITTTDGFNTVRQQLFASCELSPFTCKTNPPSIGEVHEVKISEFPTDFKPISIVLKEYNKDGCPADQNLSDQISNTLGCNRITNPGITNVVVVPKPDMPSGCLLTLYSDANCFSTSNAVLGPITPGSSPGSCIGPLNDSKGNKFVAQAAILKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFF2</accession>
    <name>A0A2T6ZFF2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1133751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000317">
        <property type="protein sequence ID" value="PUU74186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFF2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFF2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16844" checksum="2642349DA09BA573" modified="2018-07-18" version="1">MAEAKRVVGKCTGYICGIQNWTIVSFPVSQRGSPLHTFSSPERVPIYISLRRETPFSREATPDPLGVDISAQYYTLKTRQQGPLPSSLRGSSLANAQGQQGLLFGVGSNQSDLHLERLMMENYMFGGQTSRTGTIQEDPMLLMMQQWRGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFL6</accession>
    <name>A0A2T6ZFL6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1133613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000311">
        <property type="protein sequence ID" value="PUU74259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFL6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="234" mass="24472" checksum="3733441E5BD2679E" modified="2018-07-18" version="1">MGGLDDPDDLGVPDVPDALGALDDLDGRVVGDGGKCGIQRREVVHIDYTATLDQNGGRCDFRGLVDMESVEVDQNMLGVVVVNDPGSGSDVLVVVVGKDAANMGPGGRELRQAGFGNPWAVAVEAVHDRNRDTALAQVDKSVNHPVQIPMEMKGRQTGVVEGNEDLRNHCQKVFVEPKERAVAGDVYCVKSGGAAEGWALDGVSGAIHGVDGAQAVGLLFVAAMQNLTAPAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGC7</accession>
    <name>A0A2T6ZGC7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1068141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000293">
        <property type="protein sequence ID" value="PUU74550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGC7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGC7"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="288"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="35939" checksum="0A7BCAF8DE4926B9" modified="2018-07-18" version="1">MFSFRRIALTLRFGGTPAVVPRPMVPIKQTASPAIHIQPRLRPYSSSSPSKPSNPSDGASGSNIAGTPTVRRSARTGAKNSTTSTAAKVRSKVPVVPSTDHLHPADVAVSTFFAQHRPVSISHSVPLNHSESLFENIFASRKPAFEHPIYQNSPSPTDFEHIVESGWLESAIRSASNNAQQPQQQQQAAVAQPLAYQSTQDAADSANLGPDYFSYRPFCPPPPPRAQTAFLRPRLQRQLIQLLLQATTQGEGTVAISGNSKLLLENMTRQRRIGEAMPDENPGRVVMRLISVKRIRKLKMKKHKLKKLRKRTRSLRRRIESQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH37</accession>
    <name>A0A2T6ZH37_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1091856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000272">
        <property type="protein sequence ID" value="PUU74801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH37"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="12942" checksum="AB4D858BDCB7F3B4" modified="2018-07-18" version="1">MRHDHWSLTANQSDPGNGLCRWSRVWQNYCPIAVRKLHAWVASTTKQVPSQPRKKERNSQKLSYRRRRMHLARAASSPTIPVAGSPVNERLPITLLSSNLPHELAPSITLGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHD4</accession>
    <name>A0A2T6ZHD4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1110381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHD4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHD4"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="463" mass="50291" checksum="65AE7178E8518ED3" modified="2018-07-18" version="1">MASFLQRVLLPHGRSNGFTRYIQIPPLQRSSRYSSTSAATSPLEGLTLPPTPPTSSTLPLGSTPPPPRRRVKPEEIVAPELTHLKSQISLLCSTNLPGLDKTSKYYLEANGKLFRPMVVFLMSRATAIAPKQQNWQRASAELEKTFNSTVAPSEILRDTNPDLALLSSRLMPVDILGPAGVTAAGGVQVLGTQRRLAEIVELIHTATLLHDDVLDHAETRRGKPSANALSGNKLSILAGDYMLGRASVYLARLRNPEVIELLAEVIAELVKGELFQLQNTAAGASAAIDFTSKPSRETYLRDSLEYYLEKTYLKSASLISKSCRATTVLGGATEDVATKAYVYGRNLGLAFQLVDDVLDYTSSNEEIGKPAGADLELGLATAPVLYACEEFGELGELIERRFCLDGDAEKARELVHKSSGIDRTLALAESFCDTARQAISSFPSSEAKDGLEEVLEMVLTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI29</accession>
    <name>A0A2T6ZI29_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1054612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000249">
        <property type="protein sequence ID" value="PUU75139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI29"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI29"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="8784" checksum="B3139C8E31D77DF6" modified="2018-07-18" version="1">MNKLPLALNDANQAIKLDPTWSKAYRRKASVLEAQKELDKAKGVFEESLKVALAGLKASPEQKKKGRGRDQEVDRSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI30</accession>
    <name>A0A2T6ZI30_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1091091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI30"/>
    <dbReference type="OrthoDB" id="76862at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024135">
        <property type="entry name" value="LAMTOR5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16672">
        <property type="entry name" value="LAMTOR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="9948" checksum="11804A121C58DB02" modified="2018-07-18" version="1">MDPTAVTKWLDNVMGASNVTGALLIDSQTGLCLGARGKATEDDATYITVASRAALDTKGVGAVAYKDSKVILRKGGSGVLVAVYKEKDLGESPDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZID7</accession>
    <name>A0A2T6ZID7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1090700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZID7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZID7"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="708" mass="79214" checksum="FD856D0DF0DF8C9F" modified="2018-07-18" version="1">MASGGDARFFARGKVAELRTELNSDKKDKNFARKKITLKKIVANMTMSNNDMAALFPDIINCMEIQALEIKKMCFLFLVNYGRMKPEMAQRALPILIRDMDDHSPLVRALALRTMSYIHVPQFVEATVAPLRRLLRDSDPYVRKTAAFCVAKLYDHDRDLVEGSGSGNEQGLIEGLNGLLKDDNPTVVASALVALMDIWERNESIKLTIDHTNASKIVQILPDCSEWGQTYILEALMAYVPQETTEAVIMAERISPRLQHSNSAVVLTCIRVILYLMNYIADQKEISTLCRKLSPPLVTLLAKGPEVQYLALRNALLILQRRPEVLRNDIRVFFCKYNDPIYVKVTKLELIFMLANEDNIEEVLTELREYATEIDVHFVRKSVRAIGKLAIKIEPAARQCINTLLELVSTKVSYIVQEATVVIRNIFRKYPNQYESIISTLCENLDSLDEPEAKAAMIWVIGQYADRIENSDVLLEDFLFSFQDEPVEVQLALLTATVKLFIQRPTKGQDLVPKVLKWATEETDNPDLRDRGYMYWRLLSADPATAKKIVMGEKPPITAETEKLDPTTLEEMCLNVGTLATVYLKPVNQVFRTARPKRLADSPALQRHTLPTAIAEQAHRRALQPEQQEQQLVEQRTSEEGMGNLLGGDLAAAVDAADDYFSGSGGGSGTNPFAVSGGPVAGGGQYVVNQNAPQPIYSPQQGGDLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIR2</accession>
    <name>A0A2T6ZIR2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1067466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIR2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIR2"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="42076" checksum="171697DDDC2B2CBC" modified="2018-07-18" version="1">MPDSFVQLLGGKFPTIVCETGWSESMEQLKQDARLWLLKTNGETKVVVVLAFREKYPKARDGDSFELRPPPLIIETCLDTRNLTANQSLVISDAEGEKWNVDEATDAAAARAGLNAEPRRSVCEGPARHEVILERWGVGSEASCQGAPSAANSDGVTFTPNMSNNRPTPSTAGSEAIILKTQNVINDNHGATDGPTPSAASSSPTTLLSDNEPIISTTAGCELAVPPVPRDDRQETLIAGIDEDTDLITLAERLFDLNEQGGLKPPLLGNVYATLHLFKATEAGDDIVETFFANLLPPETGAAETPNVFGITLRDLLGDRVPKGHDPAYEITFPLEDLKEVIQSSIPGTTRLRATDRAIKLVKESIGSNGEPTFAQRKRQKLDPIEIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJT5</accession>
    <name>A0A2T6ZJT5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_310504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJT5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJT5"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Orp8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF212">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49403" checksum="3BDC611A33C04A8C" modified="2018-07-18" version="1">MENTPVASSSLALTPTATPPGAISNTGSEAENQSKLKTLLGILRRFIGVADIASVRFSLPSQLLEPVPNLEYWNYLDRPETFASIGESDDELERFLGVLRFWFTKDLKFVKGKPCKPYNSTLGEFFRCSWDVQETLPPVPSRPSSRNSRNSAASKPSQASSKGPVRVSFLTEQTSHHPPVSAFYIDCPEKGLSANGYDQISAKFTGTSIRVTPGVHNLGIFINLHKRGDESYRLTHPAVNLGGFLRGTLNLYVEDICYVTCPKTKLKAVLQYLGDSWIGKAKHKVEGVIYQYTQEDDGIQKIKDVPSKLVLAKIEGSWMSQLYYTVPGSNEKHLLIDLDPLFPEPKTCPPPDAMLPNESRMMWEGVTEAIHAKDYSRATQLKSEIEERQREKAAARATEGVEWRPRFFEAPTLAAGRPRLSADGEKALKGLHTGDYKLEPAAVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK79</accession>
    <name>A0A2T6ZK79_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Swiss Army Knife protein DSP-PTPase phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1089424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK79"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK79"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife protein DSP-PTPase phosphatase" evidence="3">
        <location>
            <begin position="146"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="350" mass="40055" checksum="E523FCA3974802DB" modified="2018-07-18" version="1">MFPPGHGNDHLDVGDIYWISVFGTNKMLAATGEEICLREYEKGHWNQMLICEMNSDRRISMRNRYTKRYLGRRENHTVGCVSSHSGASEWLTFTRSSLGGYWLEVSHDGKNEPRSIQRPNNYSPNLKVAEHCSQFGLHKIKNKVFRRFQWVIPNRLARSSAPYYDGEDADESINETSIEFLISYGIKNIISLNSIELSPRQKGRLRAAEISYSHIRAFECTAVTQEQFDQIWNAYDKSGATIVYCGYGDGRTGMAISAIQLFQGRALDDNDIRENGVQCPSQIAALKELRDRINKWKSRQCLALPTLTLLQIVLKTIVGQSTPSILNRHHTQHLRKKRSDRMHSDGICKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKC9</accession>
    <name>A0A2T6ZKC9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1089361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKC9"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="330" mass="37140" checksum="CB6F088F570D2DD3" modified="2018-07-18" version="1" fragment="single">MSLYGAPRPKSKPNQIPLSQSSIHALATELALARTRPRQSRTKPSQKPLSNRGVAARAARDEAGRTTSRDIGGDVDERELARSRKKLIAKAGVYERLRKGGGGDGEEEDVLVNFDRKWVEEGEPEFHSSASDDDEEEGGCGGGEMVEHTDDLGRTRKVSKKALARILRREAHTKQRAQDQQTSPSQGHLAAQPPPESVSYGPRIQTGAFQTANFSSVPTADMLAAAMPVEKEGVEQVHYDADREVRTKGVGFYRFSKDEEDRKREFQELEEERRRTERERERMAEKKRKRKEDLERRKEEVRKKRRGKVGGTWLEGFMGELEGGNAEEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKI3</accession>
    <name>A0A2T6ZKI3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1089154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU75998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKI3"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="413" mass="45135" checksum="D359BA4466E7914E" modified="2018-07-18" version="1">MQCSICTLDKPTIICVSCARGTLWPQRYDLLLQTSARDTLSDKIHEHLESLSGQTATQQRESAQLQLTLHEIHNQKASLATAREAAMVRVEELRRENERRRAVLEEAMGLRDRLEAEVSSVQRETKRWISRSKTLHGRIAEARGYLCREAAGLYGLRQKRRKSGRVDYVIGGVAIPNYLTDLNTHPHQQITASLSHLSHLLLLTAHYLSLKLPNEILLPTQSHPFTQIRGTLNARHTVTRPLSLPAPLSTLSRDNPASHTKFIEGISLLAINVAYTCFTQGLEINDVDAVCAPGANLWSLLVSRDTPVPAFGRMSHGSCLGNLATAGRVAGMARFRVGFKSVVEKVRNTLQGETIVADWDLVGDVVGGGGGGGGNAVVGGNADREVDGEDGGKGGREGRMPGWTRIRAPGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL09</accession>
    <name>A0A2T6ZL09_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1150338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000197">
        <property type="protein sequence ID" value="PUU76187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL09"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL09"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="109"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="701" mass="76325" checksum="1E63834633ECDC83" modified="2018-07-18" version="1">MVAQKKPIPTPALHKKGPFNVQVPGVEKKEGEGIPRRHPSAVTGLVSRLEPDIATTYDIVKRGAAKFGDAKALGSRRLIQVHEETKMIKRMVDGVEQEVPKQWTYYEMSGYTYLSFNEYLARVNTTGAGLKALGLEKGEKLQIFAATSANWLLMSHACASQSLSIVTAYDTLGQSGLTHSLVQTEASAIFLDSHLLPQLISPLKEAVNVRYVIYNTDTAVKQEDIDALKAAHERLHILSIEELIKLGQENPCDPDPAGPEDLCGIMYTSGSTGTPKGVPLLHKNVVAAVSGVTVIIGPYIGPGDFLLTFLPLAHILEYVFENACLFWGGTMGYGNPKTLSEKSMRNCKGDIAEFRPTILVGVPAVWETVKKGVMDRVSSLPPLTQKLFWGAMSLKGMLLRSGLPGSSVVDLIFKKVRAATGGRLKVCMSGGGPIAKETQHFISMTICPMVIGYGLTETTATGCLMDPSEWNTNSLGTLPACLEVKLVDYPDAGYFTHNNPEQGEVWIRGDSVASSYFKNEAETLAAFEGEWFKTGDIGEWDSNGHLKLIDRKKNLIKTLNGEYIALEKLESIYRASNIVGNICVYADEQKTKPVAIIFPVEAALKKLAVENSIGGEFEQLVHDAKLNQVVMRELTAAGKKGGLAGIELIEGCVLTDEEWTPQNASFPSMAVFNLVTSAQKLNRKGILQKYHSEVNRAYGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLS1</accession>
    <name>A0A2T6ZLS1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase C13 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1029100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLS1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLS1"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028005973" evidence="6">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="375" mass="42232" checksum="295DC5B3B492AB91" modified="2018-07-18" version="1">MKLPLALVTLLSCGALAQHTSNWAVLVSTSRFWFNYRHLANVLSMYRTVKRLGIPDSQIILMLSDDIACNPRNAFPGTVYNNADRALDLYGDNIEVDYRGYEVTVENFIRLLTDRVEPDTPRSKRLLTDDRSNIFIYMTGHGGNEFLKFQDAEEISAFDIADAFEQMWEKKRYHEMLFMIDTCQANTMYSKFYSKNILATGSSKLDESSYSHHADNDVGVAVIDRYTYYNLEFLENNVQSASSKHTMKDLFDSYETEKIHSTPGVRTDLFKRDLKDVLITDFFGNVQNVEIDGEDEQKWKEDVLQLSKLAVDFTMPGRKNGTCASARESAETSAPAVKKVGAVRVEGSKGWSRNAMGIGALLTCAAAWVAGSALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM27</accession>
    <name>A0A2T6ZM27_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1088043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000184">
        <property type="protein sequence ID" value="PUU76541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM27"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM27"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="8">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU76541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="31775" checksum="92E64B1E46FBAFD6" modified="2018-07-18" version="1">MGHGGTLDPLATGVLVIGLGTGTKSLSSFISCTKTYETTALFGASTDTYDCTGRILKHAPHSHLTPELIDSALGAFRGEILQKPPIYSALHHEGKRYYEYAREGKPLPVEIKARPVTALKMELVRFEKGGDHEFGLPSEEGSVEEKVVGEVMRRMGVEESKKRALEVEEEGEAEAGGSKKAKVDDTLFIEAEKTVQDLGEALGSAAHMVQLTRTQQGQFELGKNVIPWEDMTSEDTTKWESQLEAALKETSEEGAFKKGGAVEEDAVEENGGRRGAEVEAEMEAEMEAEGKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMW0</accession>
    <name>A0A2T6ZMW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Raptor N-terminal caspase like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1148182</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZMW0"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="54"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1241"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="693"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1333" mass="148980" checksum="77AF0708BF421820" modified="2018-07-18" version="1">MRHGFAEEYNSEAYLAVLEQVFYMYYTDKRHETGGNPKEETQTFPLQEWRMRDRLKTVSAALVLCLNIGVDPPGTPCAGLECWVDTTAHPAAKALEQIGKNLQQQYETLSIRTRYKQYLDPSVEDTKKFCCSLRRNAKDERILFHYNGHGVPKPTSSGEIWVFNKNFTQYIPISLYDLQSWLGAPSLFVYDCSDAGNIVANFNRFIEKHEQENMELRAKDPNALVTASYSDCIQLAACGSKETLPMNPDLPADLFTCCLTTPIEIAIRFFVLQNPLPSNLTVEQAMKIPGRLQERRTPLGELNWIFTAITDTIAWNTLPRPLFKKLFRQDLMVAALFRNFLLSQRIMKVHQCHPISSPPLPETHHHPLWQSWDLAVEMVLAQLAALNRASDGGPAYEYQHSGFFTEQLTAFEVYLSQGAIDRKPPDQLPIVLQVLLSQVHRLRALILLSKFLDLGPWAVNLALSIGIFPYVLKLLQSAAQELKPVMVFIWARILAVDASCQADLLKDNGYSYFIQILSPASGIPVGNASEHRAMCAFILAMFCRGFHQGQVVCMPPNVMGACLAHLGDENPLLRQWACLCLSQLWHDFAEAKWQGIREGAHLRLCELATDNVPEVRAAVLYALTSFFGIPEMSEEVAKIERDVAGSLLIMTADGSNMVRKELVIFLSMFVKRNEGKFLVAAFEQMVQERDNLTGAARAQAAEGMRPSTQPSERHHHRVSSGPGALGAEGANGSADRKDTLGAISPNTIFSAIWQALLMFSVDPFPEVGQAAQIVVDYVHLALLQSPLGQHTQDVIEEISRANLRNFSFTLPTNSIPESKRPVSPGPTKAEGYFTTSLRRSASIAASLKQMALGYANGETTPTNSAPAAPKTLKGNWLANGSAERSPEWNRPPDANDPRSSSTSYRTAKEPITRNFHAKGVDKVPSIPLKSQFMEWSIEVCYPWRCISSPTNFDQYFREPQMKPNEADEPGSVDYNQRLWRRTRNDRIIIDTQTQKERASTSRWDHNKGVFNNGSLPMRLLFHQFESHLIAVDEKDGVSVWDWAKGVKTNHFSNGNPTGTKITEIKFLNEDDVALLMTGSGEGVVRIYRNYENDGEVELVSSWRALTDLLPSRRSSGLVAEWQQGRGTMLVGGDVRVIRVWDAPREMCMSDIPARSGSCITSLTSEQVAGNIFVAGFGDGAVRIYDRRLAPRDSMVKVWKEHKAWIVKAHMQRGGMRELVSGSATGEVKLWDIRMDSPVRGFLAHTKGMRSLSVHEHAPIIATGSTWHDVKLWNTSTPKDLSLSTIKPYSSFLHQNRSNPVTGLAFHPHRMMVACSGAGDNHISLYNCDSKGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNJ4</accession>
    <name>A0A2T6ZNJ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tim17/Tim22/Tim23/Pmp24 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_988265</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNJ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNJ4"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="162" mass="16360" checksum="F3D3484ADA3FE141" modified="2018-07-18" version="1">MRQSGVVDHSRDPCPWVVLSDFGGAFAMGAVGGAIWHGVKGFKNSPSGERSMGALTSIKARAPVLGGNFGVWGGLFSSFDCAVKGVRQKDDPYNAIIAGFFTGGALAVRGGVRAARNSAIGCACLLAVIEGVGIGLNRVTAGGSKPQNPALPSEGSTEALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNQ7</accession>
    <name>A0A2T6ZNQ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1086937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNQ7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11120" checksum="55504F336A24F175" modified="2018-07-18" version="1" fragment="single">MGFPGKVIMFATPPSAIIVSFSAIWAWRSWCSCLRRSRASHICLVLAATVRFPPAVTRPIRTSSRRRGLETSERSIVCSMKDEVIMGVVCGDACGVVCGVVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNR5</accession>
    <name>A0A2T6ZNR5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1102037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNR5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNR5"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="248" mass="27863" checksum="E7820ACDDE17523A" modified="2018-07-18" version="1">MARAWTRDKEQASSAGEQVPETPPNGVEIYTNDNPPPAPTLHYWRQRYSLFTRYDEGIWITQNGWFEVTPEKVAKKIADHVLDSPVETVLDAFCGIGGNTIQFALSTSCRRVIAVDRDQTAIDCARHNAKVYGVLDKIEFIVGDVFQLVEERDPRLVVDAVFMSPPWGGPSYRDFGVFDLETMEPYPGTHLVEQAQKISPNFALYLPRTSDLNQIAKIMPGPKVQAIHYCVRQRSKALTVYGGCLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNS1</accession>
    <name>A0A2T6ZNS1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1086890</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000162">
        <property type="protein sequence ID" value="PUU77139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNS1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNS1"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="381" mass="42736" checksum="4BAFE642DA0281B0" modified="2018-07-18" version="1">MRLIRKSIERDMSGSVTLYPEEPEDMWHAFNLIRPSDTVRAPAIRRVTTESRTGSTNSQRVHTTLTISVRKIDFDAQGGQLHINGQVTEENKIVSVGMFHTLDLELHRNFTLIKSEWDSVTLGVVKEACNPGDRAEIGAVVLQEGFANICFITEYMTILRQRIEVPVPRKRVGSTTSYEKGLQKFYDVVYQSIIRHFDFSALKVILLASPGFTAEGLKDYLLLTALQTDYKPILHSKKKFVTVHCSTGHIHSLNEVLKSPEVAATLADTKFAKETKAMENFFEMMEKDEFRAWYGPKEVERAVDKGAVGTLLVSNSLFRSNNVAERRKYVRMVEEVKKGGGTSLVLSSIHESGIRLDGLGGIAAILTFPLHDLDESDVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNS9</accession>
    <name>A0A2T6ZNS9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000162">
        <property type="protein sequence ID" value="PUU77127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNS9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="10694" checksum="C0B3FE02F62CCE95" modified="2018-07-18" version="1" fragment="single">MITIAHFILLHLQYSTPFTYLLLPLCYLPYYFYYLLPSYSLFFLLFFSFSFFPSFFSFSFFLLFFYFSVFPLFFSPLFSPLSPLLFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPA3</accession>
    <name>A0A2T6ZPA3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TIP41-like family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_987258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPA3"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="269" mass="31237" checksum="ECF39115CA32FEE7" modified="2018-07-18" version="1">MSRSPPLQTAPNIDVGKSITRGDWKVTTHKRPILNSTEIEAMTTTLGISPPEMIFGNNSVEVTNERLNWSISFNALDALELVDKSGESMLKVSYSEAWQKMRERVHEDIKEIVKPYDWTYTTNYQGTVYNTARPFQQTGSEIPFDKLKRPDPILLFDDVMLYEDELADNGISILSVKIRVMPERLLILQRFFMRLDGVLFRLRDTRLFIEFETGEIIKQYQAREDTYANVRNGLYMHPPEQIPSLLRDDSFIAERLPVIEMERERVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPI7</accession>
    <name>A0A2T6ZPI7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Urb2/Npa2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_175920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPI7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPI7"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="28"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="266" mass="28893" checksum="4FF3B67F52A03ED1" modified="2018-07-18" version="1">MAICVSKTFSKLSRNLHKMPTAEDFLTVAACMETILHEKPWVIHQSNIDESLTAVTLSNSPSSGPHFTIANPDEIYLALCNLTRTVLTLHRRRIRGGRYHLVITTLQSLLRCIIKRKPASLRKKSDKIVHPPWLLPAHSSTPTQLPPGITPAGVDEGFNRLLGTFCEPSVGSVRPRHAGATAGIDSEREKEKREVAGCVGGLLGEVLKGGLAGGFEGDVSIGVGKIFQALGGEGVKVFAYGLDKEGRAMLRGMWEEFKKGDGGEMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ30</accession>
    <name>A0A2T6ZQ30_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_149092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ30"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="167" mass="19184" checksum="3FCFBF697F11A2C7" modified="2018-07-18" version="1">MFPILEHGSGQVRTRSPHSYCLLPSVKTLTRSSTGPKNRETRTQIKGNVLYPSIHPIVGTPSSPDHGNTRRRSDPIILEIRYFTRVLIDDPRRGYGSSNFETNRTNWPRPTTRQTIRVCFPQKNTQRPLRHSAQFKMLNTGKQVRNDQPGQARVYLACQNFFLDHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ61</accession>
    <name>A0A2T6ZQ61_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_986298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ61"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ61"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="702" mass="80076" checksum="31759B94F23ACB4F" modified="2018-07-18" version="1">MSETPEGRRDVKNHLLFEISTEVANRVGGIYSVIKSKSPITTAEYGERYCLIGPLNRTSAAVEVEALEPTNPALKATLDAMSDRGIQWLYGRWLIDGAPRVLLFDTGTGYKHLDEWKGDLWSTAGIPCPPGDAETNEAVVFGYLVAWFLGEFVSHEQSRAVIAHFHEWLAGVALPLCRKRRIDVTTIFTTHATLLGRYLCAGSVDFYNNLQYFDVDAEAGKRGIYHRYCIERAATHSCDVFTTVSHITAYESEHLLKRKPDGVLPNGLNVVKFSAMHEFQNLHAQSKEKIHDFIRGHFYGHNDFDLENTLYFFTAGRYEYRNKGVDMFIESLARLNHRLKISGSKTTVVSFIIMPAQTHSLTVEALKGQAVIKALRDTVDNIEKGIGKRLFERALRWHDGEQVPAEKDLMSNQEKVMLKRRVYALKRNSLPPIVTHNMIDDQADPILNQIRRVQLFNHPSDRVKIIFHPEFLNSSNPVLSLDYDDFVRGTHLGVFASYYEPWGYTPAECTVMGVPSITTNLSGFGCYMEELIENASDYGIYIVDRRMKGVDDSVNQLCQFMYDFTVKSRRQRINQRNRTERLSDLLDWKRMGMEYVKARQLALRRAYPGSFDSKEPFPFFDGTEQKVSRPLSAPGSPRDRSGMMTPGDFPSLQEGMEGLNTDDYVSWRLPEEEDPEEYHFPLTLRTPITKRQQPSVNGEQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQP8</accession>
    <name>A0A2T6ZQP8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000139">
        <property type="protein sequence ID" value="PUU77810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQP8"/>
    <dbReference type="OrthoDB" id="5406607at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="514" mass="57874" checksum="B9BE5FEDEAD6FE72" modified="2018-07-18" version="1">MRRILNIRTISTVLNILSWIFLLLPAIQALPLPFLTPRADQGVVTVSRERVCLTPAPWTQILSFFLTNYIARIATFKKTSGYTGSRDHLRTVISLFVPFYGISQAAETIARGARFLGKDELGGALYAGALCVVQRLETWRPRNGDVICGCIIEPPPSRKGRKRKGRRKKDLIDTDEAIVQIQLLTAKQIDDPKKWKIQGQYTLPQGYCFSFLPAGTSIGPKNPDTKREDIVIASSYGTAKSFTGVLQIIISVFSLYSSSSDQVTNYGYATFGFSVIPYTVMSFLNAIANSIEADYDTLFMVESDVMDEAYERTHLEFVGTVAVLKEEHPEEGVDLKFRRSREHGWRAYEVDEYGKEVGRRWRVTFEEEEVNNENFSTPARINENAARIMVPAEGQYRRKKKLVKFSQKVYNFSVFIIIFISLAIPYIVIAGLSHFKPGGSTTKQRTFMMGWLVVGQVIGVVDLIESTGGGKKWWWDLLENSIKVVIVIAGFAFAVGGFIEAGKMLRNFGFCFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR52</accession>
    <name>A0A2T6ZR52_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR52"/>
    <dbReference type="OrthoDB" id="10429114at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015667271" evidence="1">
        <location>
            <begin position="24"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="17833" checksum="DE30394E48B7FF17" modified="2018-07-18" version="1">MKSKNLLVIILFSIILLYHPSISTTNSPIDPSLFRDPLTHDPTAPLHTHPRIIPRGAQLQCTTTATSPTLSDIFIATNIIYERKSTWCTQTGKRCTTFATHGSASLAICAAPGWGVKCDDLAWVGQTVARYCEDKGKAAGRWMFPAPEGAKDGGFEGAAVRGVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRJ3</accession>
    <name>A0A2T6ZRJ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1193558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRJ3"/>
    <dbReference type="OrthoDB" id="5355583at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="36189" checksum="F00D3B8093ADFD67" modified="2018-07-18" version="1">MGNEKAETRKRKYKSTIQDSGIMGSEKTVTRKQEYKSTIQVHPKEVPNTTEDEPENADPKRRKSKSKWTASSYSKVTIPEAEMWLNFRLTLRGIPVKKMLEGKSVLLGQRLISKAKKQVYRGLVNYLKAGGYPTEADPDFKEANINDLVAFVTYPIISLFNDETARQLHISREKEIASLDSTTSGMEEFVVMDYICLGQTKYVLIIEAKRVSLGGARKQCFLSMKDMRDQNGGGIVYGFITNGDSWRMISFDGKFTMSEKIELMFDTMDEDKGRWMADYSILVDCFNFALSNGANDLVEEEEEEEEEAARCHSKGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRK6</accession>
    <name>A0A2T6ZRK6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Autophagy protein Apg6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1127287</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRK6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRK6"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="163"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="294"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="207"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="503" mass="57108" checksum="7DCFDD975A715891" modified="2018-07-18" version="1">MKCQKCRQAIRLHGSLEDLSPAAFNLLVGSSANERPHSTDQTPTPQRPTYPQDRRDVYEKASRNSPAPLFKRTVQPKHPPPLTAPHSRQNSKSVYQNPADSYVMLSQSQVVPPTQSASRSAGSSLQAEYTVGNDHDQNDLSQRMRTSAVLFDILSSRSDIDHPICQECSEMLTEGLAKRYANVTRERDAYVDYLKRVNAEIPTDAEREAAAQELEELKAQAAAELRELQDMEQEKAAVDAEIRALEEEKKKLDEEEQEFWREKNSFSLRLEAFQNERDGVNLQYDHDSRQLEKLQRTNVYNDTFCIGHDGYFGTINGLRLGRLPNQPVEWTEINAAWGQTLLLLATIAEKLNFTFDSYRLKPMGSSSKIEKLDPSANPANEPKVTILELFSSGDLPLGRMFMHRKFDQAMVAFLECLRQLGEFVERTDPEVKLPYKIVKDKIGDSCIRLAFNQDEAWTRACKYTLTCVKFLLAHTRFVTPSPASHCIILMEAVMGELTFVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRS5</accession>
    <name>A0A2T6ZRS5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="5">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylate kinase 3</fullName>
            <shortName evidence="5">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ADK2</name>
        <name evidence="8" type="ORF">B9Z19DRAFT_1084848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRS5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRS5"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="7">
        <location>
            <begin position="168"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="5">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="5">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="24"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="131"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="27923" checksum="4F076D9D82EAA47E" modified="2018-07-18" version="1">MNTGTRNLSKLKKAARIILVGPPGCGKGTQSGRLLDHFKLTPISSGDLLRENVRNRTPLGIQAETVMRSGGLVQDSLMVKLIVGELSKRGWVETRGNLTSGICLTGPLSVIGGPITPRASDSPTASFLLDGFPRTRNQAQSLDSEVAMNLVVNLDVPHDAILDRIANRLVHEPSGRTYNVTWNKPKNPGVDDITGEPLTRRSDDCPETFSKRLKSYAEATQPLLEHYDKAGVLWTVSGSTSDEITPQLDAEILKRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRZ9</accession>
    <name>A0A2T6ZRZ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRZ9"/>
    <dbReference type="OrthoDB" id="5402816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6383" checksum="7EB2CCD5FB8AE7DB" modified="2018-07-18" version="1">MPALESHLLYKRKGKGNWAKREKGVIVVFCILAALAILLGGLFIYKKVAARRARSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS39</accession>
    <name>A0A2T6ZS39_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1101441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS39"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="665" mass="72502" checksum="306E3DCE9A690E97" modified="2018-07-18" version="1">MSIPMNSRSRSHSTSSGKSVIMPSPMSVRSIEGLKTGSGLQPCAATPTFVLFAQGTSILCLLYDSLALERRFEGHVEDITLIVADNTSEDGVGRIVSVDASKRAIVWDSHTGDELARYDAFAEIKVAAWMKNGNLAFGDSMGNVILFDPLTSESISARTIYDPLCSIAPAADCKTFALGYTNGSVLIAALSPSFIILHTLTTTSLQPSPIATLAWHASSSRQKSDMLATQTRDGDLRVWSVPKSLDAEEGARVVRILKKLDSNRKGDNWMGWSRNGRIVQYSEGETTIWDVRTKKVTWERVGTLDNVCGITVFGPKGILFTLGKDDTVQQFALYPPTLLANVQHTPTVPPPSPPVSIEEKKVVEEEQYEEVFRRPFSTEEDAYLVATMSPLGRIAHELEQLEKMEGEAGLGITNVANVAPRPRTGSVSSRSSDGSIGKGHQHTLSTTSSKGTQRSSGDQSEFSQATSISTSRKDSFGSTGAPMPSPSRLPHPLRQEIHQSPDEARTATPRRDTDLFAGLRAKLASVTYQSPRIGSPRSNMSGDDHRKEMLFSIFGWKGDIEHLIQDQLDSVDARSMSAVILRMWLGDLNQNSLSVLLGADFSVPGDWVFLALSAMDGQKSWAHVVRAFVMRLLQKGELHTAALCLLALGGKNDAVEVYVSHKKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSM7</accession>
    <name>A0A2T6ZSM7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1084090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSM7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSM7"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="258" mass="29479" checksum="BB9C7E997FF1D773" modified="2018-07-18" version="1">MSSDNIYAMVDPEIFAAVQEQIERDSQVKEDIREALKKIDKEVRSITSTLSRVHIVSPQHVIELTTTADEGFKRLRDSLQGLINIVKDYPYYKYNGIWSRDIQNVTFLVLFQGWLQRSYAPGNAENSLLTIEEAGGVLGIPVNLKTEDKFHLTIEEYLHAVLSLVEELTRLTTNAVTQHDFLRPQMINRFIKDIHSSFQVLNLKNDSLRRKGDGLKYNVKKVEEVNYDLILRNLIPTGADEGGTEKMEDAKGPSEQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTE6</accession>
    <name>A0A2T6ZTE6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000108">
        <property type="protein sequence ID" value="PUU78747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTE6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="30761" checksum="E8FD06D57D0F59DB" modified="2018-07-18" version="1">MVNRGSSSFSASSVAQSGVVLTKSVEKIFALEAEVSRLWHYVSVLSRRLHLLLKESERSGPPVVPCHSRPPSLAVTDNSPPPLVDEEVAGSVAEDVARSVVSWRSVASPPVMVRVPDSPWESLPFESSDSSVVGPVSSGDSDVVLGGMIVASDSARSMRVRRPGKRACSPISEELDGGGDPVVPTVVSSPSGLQGERVGAVVPSLASIAAHTSWLEARLASPGVVADGRSSELVVWGIRYLVGQRVFDHHLCPRAAAWDNFGGCLIDGCGFRPVGYDRVAADWHSLYEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTP0</accession>
    <name>A0A2T6ZTP0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_32991</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTP0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTP0"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="38"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU78851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="474" mass="51932" checksum="E1855364878A8570" modified="2018-07-18" version="1">MSSANYESITQEDRDEGTSSPEGRRRRRQTKIAHPAGEASWGSSVVNLLNTIVGAGVLAMPHAMSQFGMALGVFVILFSGFMSGFALYLQTRCAKYIDRGTASFFTLSQLTFPNAAVVFDLAIAIKCFGVAISYLIIIGDLMPQVILGFNQNAGNVECLVDRHFWITGYMLVIIPLSFLRRLDSLKYTSFVALVSIGYLIIIVLAHFLKGGTLDGRGDVRLITWAGPIEALSSFPVIVFAYTCHQNMFSILNEIKDVSHESTLNVILGSIGSASSIYVLVAITGYLSYGDNIGGNIIAMYPSSWTSTIGRAAIVILVMFSYPLQAHPCRASIDNILKWKPFQRRVGLRPPSPGRVHEMSDWRFALITTAIIVGTYLVAMTVSSLERVLAYVGSTGSTSISFILPGLFYWKISNPESDNHRLLKEDEDSGEEGGSYGADTWRSKLLRRGALGLAIYGFVVMITCLTLNTFYVVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUP2</accession>
    <name>A0A2T6ZUP2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUP2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="19503" checksum="EDF04E61546AFFA2" modified="2018-07-18" version="1">MSLPSRLNTQEKGLAHEAALPPPWDCNTTPHPPFLIGAYIAMHAPTCMMLKLGGPSAVPREESRAKGAKKFQALQLSIDKQQLQEPRTVSHPIEPVILPNLAVFQAHRTGRATRRGPVLSVVPSWDYHVLGLLRLLHVVVDYRPAFIYSPTHAPTFWLGKPERNINISNDLEALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUX1</accession>
    <name>A0A2T6ZUX1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_980076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000096">
        <property type="protein sequence ID" value="PUU79263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUX1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUX1"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="139"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="382" mass="39765" checksum="E01290090F75466C" modified="2018-07-18" version="1">MAEHIIPNQYIIVFKSDIPKERCQEHCQWATELHTQRISARSADSDAPETSGVLHHYSFPTWNGYAGSFDEDSKNEIETREEVDFIEPDYKVYTKALVTQSNAPSWGLARISHNRKLTPETRTTYTYDSSAGEGARAYVIDTGILADHEDFGGRATFGHNAVPGSSDTDMNGHGTHVSATIGGTKYGVAKKTTIIGVKVLGDNGSGSNSGVIAGLQWAAGHAEADGVANMSLGGPKSQAMNNAVAAVIRMGMTVCVAAGGESTTETGSPASEPTAITVGATDDSDALASYSNYGNLVDVLSPGTNITSAWIGASLDKTNTISGTSFATSHVTGLAAYLIAKEGLSGSTAVTKRIKALAGKNPGQVAKAGTPNIIAYNGAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVH7</accession>
    <name>A0A2T6ZVH7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1081618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVH7"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="113"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="284" mass="31267" checksum="0B232B3FCE366993" modified="2018-07-18" version="1">MEPYSRIFRPELLGFKNYATGLKPEDVTSYCPFTGLSFMTRLDAYNNYIPDQTSIIVKIHGAFSLSPSPSSTPSPSSISASAPASAAASASTSWSATDSPRNTSIASQTGTQSTYPATLGPAGASTAFGLFYGWNSPRNSVGIVPQVLYEQSKPHVDLFTAGMVLMNLLQTVNFANPLNGVGIRNVVLVTDSNYLFSCLTEHVYAWQSKGFRNAKGKEVSNANAVKWVESLVEEFERHDICVRFWKVDKKDNWEAVDLARRFLDLHNQFRRRHGIRALLNIGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX27</accession>
    <name>A0A2T6ZX27_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000076">
        <property type="protein sequence ID" value="PUU79994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX27"/>
    <dbReference type="OrthoDB" id="5394791at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015657338" evidence="1">
        <location>
            <begin position="23"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="102" mass="10953" checksum="C1B8A78D252304F1" modified="2018-07-18" version="1">MLLKSLPVLILFLGHAHASALANPFPRVDSSHLDKRECIYNCKCRQGVAPGVYCGNCGVIEGCRQLGSACNFDVYQCGHNGNCCDYGPRDSCADRKGPCGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXC9</accession>
    <name>A0A2T6ZXC9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1063695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXC9"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="81"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="295"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="464" mass="52380" checksum="6355BB208FE03B3F" modified="2018-07-18" version="1">MSTILQVSSRMRHCASSLESSLTQAALVGSHAKILRSRVIPTTTPTITPKVNARHLSSIQHNPRWRASGVLDSYVAQPAHPISLRQLVFFGGRNLDEKKIISSANYVRTELPLRIAHRIRDMQKLPYVVVTNRHLSEVYELYYKAFESFRRIPEIKTLEDNEKFCEIVKTALQEHLTVIPSLAMGVLECNDLVPSHELDRFMNVILRSRISRRVIAEQHLALTDTFNSPFHFPDSVSHQPHDFVGEVFLRCNAREVVEQVGKHTLELAREANGSTSPIPEIQIEGRLDTTFPYIPSHLEYIIGELLRNSIQATIDHHTPSTTSLPPIRVLICHTKEHIIFRVSDQGGGIPIAELAHLWSFAKGPRATSYLQNFSQVPKMAATLQELQKTAHTHSRRESMDTSLSRLTSRSPNLRLGMGLPMSRVYAEYWAGNLELHSLDGYGTDVFLQVSKLGNKCEQLNLDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXI2</accession>
    <name>A0A2T6ZXI2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CTLH/CRA C-terminal to lish motif domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1045122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXI2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXI2"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="30"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="207" mass="23322" checksum="C9C5E3222DA45438" modified="2018-07-18" version="1">MNYLIIEGYKSAAVNFAQEANMSHQVDLDSIQERVDIRHAIHHGDIQTAIERINELHPELLETNLPLHFSLLRLQLIELIRNCTQSPDGDISEALAFATTHLAPRAPGNSKFLQDLERTMALLCFPMENLAPPLAELMDPALRRQVAAKVNEAILEVQGVPKEAKIRRLVRLRAWAEQRMRSERRDMPNMDLGLDVASQTSDDAMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXK6</accession>
    <name>A0A2T6ZXK6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1079987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXK6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="61" mass="6598" checksum="BBCD5369F851D790" modified="2018-07-18" version="1" fragment="single">MGVRWICCREMGQVVDESDSYVARIGPASHQLDKKFVNPATPVANKVVCSSAGMQAMISLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY17</accession>
    <name>A0A2T6ZY17_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY17"/>
    <dbReference type="OrthoDB" id="5491940at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="762" mass="84603" checksum="4E0603C9D732DA07" modified="2018-07-18" version="1">MSYFNPPHTNYLHNTSPSFELICIEMAQGDDLGEQVANLLGGEGNLTAFAATEQGRERNRTQLEHRYTDRDGEGSVPLHTDKDHYTRHREEGEDKQGFEDGSPNSSGRHNPSIECAGLPITSTILPDIRENRQKRQAEAIPNLPRAPKRRVITDTGGHVTRGGTNSASDGGHSVASQYGDGFIIMCEVTNYRAIKEKALRGHGRKEQERKTVEHLFKFYTMPQTMARAIRLLGTICSTDPTTVPIGCLTVEQSDVGMAEPLPDSWTKAKAAGLWAHNMLQKVTKVHEEITLREVMAVITLHLIHRKVIEPAWKECSSKLRANIATETVWDFYYVSLTGKQASRTALRTFKDHIGYGEILFNFAQRLGAPALLMVAAARRGVSAAARELGKSSNVTRDLTAALCTSPLWWCFSHAIGNLTVARLFGCSWPKVTSDQLAYWIRSQPMPTSTLRKWETACHLESIKLESNLPPDHLRVVPRENYPKVTIHWLGHRLEISPIIQCVDIEQCNQVEELGAWLRGLVTTELEIGASQPLGLHVLHDLLPGRVITSGLTDFFCAFHNSRCVDGYIVLDSSQSQLLLKQLTPHTGLHKLQEAIGEPMWERNYREILVAISGEDGIVGCQISILDKCAFIYNWMEGAMGAKLEGECIEVGVGSLIAHCAELTILKAARRCLPAIGWTIERVPLDPSPGVSTKRDSVLCFLHLSRSLITGTKCPLYSPGFARPATVDEITHGLVVDGFALSLGNGWRVHPRYWFGLSDIKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY35</accession>
    <name>A0A2T6ZY35_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Superoxide dismutase copper chaperone</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_975418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY35"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY35"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="4"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="245" mass="26051" checksum="390887A74C78CA7C" modified="2018-07-18" version="1">MIDPFQTLFAVPLECDSCVQDVSSSLKKLPGILSVDADLQKQLVTVEGTAAPSAMVSAIQDTGRDAILRGSGKPNSAAVAILETHAKDIPNPVRGLVRIVQVSSKLTILDLTIQGLSPGRYHATIRASGDISRGAASTGDVWERQKSEKEEADAPPRGEFGPIDVGKSGAASVLLDKPIEVWEIIGRSFVVSKERDGSFKPDGPDTVVGVIARSAGVWENEKTVCSCSGKTIWDERKEGIERGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY90</accession>
    <name>A0A2T6ZY90_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY90"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY90"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="56717" checksum="86CF2F8B76459971" modified="2018-07-18" version="1">MARLRSMEASGASPVTPKSALDRIAKASSKLNSNATPATTLEYPSLAKLEYPSLDKVQHPVIPLTTPKANSRIPKYAATTGKKLGNLSEKLEDEATPLVKPAQKFKVPSTGFEFRVIKTGEKKVEELVPPVSPATAAVATPVRQIAKKKSRRFSDAHRRQFEKMESITTHYAAKRTPKQPVTIEKMPRGVKRTKSRAELGDRGPPSSPSPVKMPVEGPRNAKDDGCSPMKRTKISAVNEEKTTLTSKPSGIPRLGMTPIKGFKKRPATVAKISMGGRLNLTPATRLASLVQAGATPSKIPSAITTPVVEDTDSAPNTTALLNRHTKLPSIDTPKKETNPLAPPKTDGFTFRSKGDGIGYKRLSDMHSLNYNLNKGTPTAPTPLLTPMKMSAEDPFVGMARRAAIEWTPVAAAPAEKRKAPHSDGDSSGNGAGYGEVIDTVQESGARKRLKFAPVEEPTAKATEAKEATAVAAGAPAMKKKSLMNRGKAMLLRSRLNMLAAPKRRVEKDAESNGERKDKDVGRIRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYD0</accession>
    <name>A0A2T6ZYD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UNC-like C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_974587</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYD0"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000082">
        <property type="entry name" value="Sad1/UNC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015450569" evidence="6">
        <location>
            <begin position="19"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="182"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="549" mass="60388" checksum="DA2CCB98C59FAC1F" modified="2018-07-18" version="1" fragment="single">MLLLLLLCLTATTTTTVATTAVTASTCRAVTANYITHRLPQQCLRSKSGSGSSGGNYTAASIAVVTTRVGGEAEGGTQTAIEASGPTQIPSAGSTISSENAPTDTAAPSPPPPPPIPEATENEGEDSPLDTAKFLSFEEWKAQNLARAGQSSESFEDRYKVGRSDKPNPATANGDGVGGGDGDSPDPRDYTRSRNAGTTCKERFNYASFDCAATVHKTNPEAKGATSILVENKDSYMLNKCGAEKKFFIVELCDDILVDTVVLANFEFFSSMFRSFKVFVSDRYPIKQNGWKDLGTFEARNSRQVQAFLIENPLIWARYLKVEFLTQYGNEFYCPVSLLRVHGTTMMEEFKHHEVSAGGAEEDIIEEVVPEAVAVNIEEEVQARVTAPEHHHSPSPPPPPPLAPSGSQVTHSHSHSHPPSAVPTTQESFFKTVHKRLSLLEANATLSLQYIEEQSRILRDAFVKVEKRQMEKTAQFIEKLNSTVLAELHSYREQYDQLWQSTVIALESQNTHADQQIQTLTTRLTLLTDELLFQRRIYQLQSLLLLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ24</accession>
    <name>A0A2T6ZZ24_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1106886</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ24"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ24"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="120"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="219"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU80710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="308" mass="33985" checksum="C9C3CA42198AB74C" modified="2018-07-18" version="1">MGAPQAVPIDRQHVFDTPTAPEHSPYRGFVAGVFSGATKLTVGHPFDTIKVRMQTSTSAKFKGPLDCLTTTVGKEGLRGLYKGATPPLVGWMFMDSIMLGSLANYRAAIKSKFYPNHDTLPSFGHGMAGILSGWTVSLIAAPVEHVKARLQTQYNAKGSKAGVKYSGPIDCTRKLLSNHGIQGLYHGLGATMIGRTFFFFMWTSYDIMTRQLEQRTNMSPMLVNFWAGGLSANVYWLLCYPSDVIKQRIMTDSLENRKFKNWREAAVAVGRQSGVRGYYRGFLPCIMRAFPANAAALVAFEGVMRHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A089</accession>
    <name>A0A2T7A089_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec62/63 complex, subunit Sec66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_972422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A089"/>
    <dbReference type="STRING" id="42251.A0A2T7A089"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="215" mass="23811" checksum="7077BA2DDEFE773D" modified="2018-07-18" version="1">MVKLSIIAPLVYIAVLVGTLAVFSSLYRKRKANKAASLEPWFGPHYSRDIYLTLLHQENPKVPDSILKAALVRRAAEDIRRIVTIRQAKGSLQQLLQRGSIGDDLWTRFTVAEAEIEEELKDVALEANGFSNEWAASIFQSAHEIVQATRIRERAAEVAEQAAVERAWWNGKRERASRELLGENSDEDGVLVESSGSKGAARPGTTAQRKGKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0D3</accession>
    <name>A0A2T7A0D3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1099929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0D3"/>
    <dbReference type="STRING" id="42251.A0A2T7A0D3"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF228">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="45"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU81202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="353" mass="39271" checksum="A9C781A96A7D1753" modified="2018-07-18" version="1">MSHQFGLPAPPVPWYSHPRFNTLKDHFTGSLHHHHHSHLEPLRIYANGVYYPNWRIYKNEPPSSLKLGLISHVFYSFAWVKPDGTVYLSDEWADSQIDVDGVKGCLRSFQNLKTKHSHLKVVLSVGGGGKGSDNFAAVAANHASREQFAHTARELVNEYGLDGIDIDWEHPSDHEQGHDYIALLAAIRQHLPSPRYVLTSALPAGEWALQNIDLHRAHQYLDYINLMTYDFSGPWSVPSSKILLGIPAYGRSFLGCHNPGQQYSGSAGEEGTFEYKDLPRPGATEYTDDKLGAAWCVGGDGGWVSYDNPTTVKLKADYAKNNRLGGVFFWTGTADGEGPRSLVEASFSRLHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0G0</accession>
    <name>A0A2T7A0G0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1062894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0G0"/>
    <dbReference type="STRING" id="42251.A0A2T7A0G0"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="7">
        <location>
            <begin position="573"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="446"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="74290" checksum="EB99D0407FCA98A1" modified="2018-07-18" version="1">MISDELFEECRLILQDTNLLEEDQTEKVSALIASKTDLTGTPLDNETLDVLWRYREKTSSTSSPPIRHAHTIVRRASPAPWQFSRVGTPTPSLGSTPPMAPPGFSPSFIGKGSPFPSPRPSPRLAYSSPLIPHSPNLNNYEPSFASDPGFPPEVYGDFGSETVAWLVGDDNSMGFGNRSSLQENMSPHDMLRSVLGEGRSDEEIEQALGMCGYDLSSTLAMLMEQHGSSAANQTTENSTVIGKSTMPVPVPTARPVTPRNGVVCRFFLSTGQCLRADCRFSHDLGTTICKYWLMGSCLAGETCIFSHDPTMSVSKMTIDNNNNNSRNSTPPPQLQFHDSTAFPALASDQWGAMGSVLGAGINPPPGFKLPISRPNSRQQSRERERSSTPVPAVDDTDAFPSLSSSAKASGNGKKRRNNRSDGGNIPTGPSSLADVVRATPSPSPHSNRTSTSSGASSNRWSGVGSSPSSKRSSRVSAAHIPAPQQIPWMETGSALNRVYLKHRKDALAHGVHRAKYLQQANSAWQRNDAKSAKEHSRKANNENIAMMKAHKEASKAIYEERNKGASSSTELFVDLHGLLPEEACKYLEDILVEHQTSTRPLYAIVGTGHHSKNNKDKIGKAVRAFLDEWKYAYRDFSVSGDKNAQGGILGIDPSSFDKSLLAGEAGAGGSTGSTVTKKEPPKGPGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0N3</accession>
    <name>A0A2T7A0N3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1077516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0N3"/>
    <dbReference type="STRING" id="42251.A0A2T7A0N3"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="9">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="18939" checksum="0E1BCCE1A8208E55" modified="2018-07-18" version="1">MGYSTADKLYLAFFAMFIPVVAFVDLIPIWPRAFIPAPLWALHRFYLDNFNDQLAIKAPTWFSVFLFFEAFYNLPAAIWIFLGIRRGGSSSWVHMCMFGTLCTLSTVVCIAEIRQDPDMTALEKNMVMLCYVPFAIIFPIMAVHNMIRIQGKLALADRAAIRKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0W1</accession>
    <name>A0A2T7A0W1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1077326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0W1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0W1"/>
    <dbReference type="OrthoDB" id="4392610at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14610" checksum="9A097A6EAFF7B2B1" modified="2018-07-18" version="1">MVPDSTIIRSYRTLYKAGLAAVQYSSPARYSIREKLRKAFRRSDPSRFSQQRIDNTVQFLRTAARRKGMEHRIVKNLCKVAYWQLHSRNNRKLVVGKGGTLVTEQAFSSYLETIGLLNQSMDLELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A120</accession>
    <name>A0A2T7A120_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1191170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A120"/>
    <dbReference type="STRING" id="42251.A0A2T7A120"/>
    <dbReference type="OrthoDB" id="5301470at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="328" mass="36579" checksum="C3EAAA365FD970CF" modified="2018-07-18" version="1">MDPMGGLRDINSLADRPRRPLSSTFSEHEEDLTDVDFAARPDAALLEEGDYTSSDEDSVRRERRRTRHERTSSTIYDRAVSTKVNPMPIGDQLQPESKIRIIIRDFKENPEKPLSRARVVLRAFSLIASGTVVGTVAHMLWHYLDTKDELHKGKLVWPANLSVTPTALMLAIAVYTFLTDLGFLIGSAWKNFRYLKNKIAATIIALNSLTSCIGWILSIVFSLRQRDNPTLLWVCSVKGSAQSADDSEGSPMDFALHCSELNFTWIAACIVAAAQGLVVFTIVFSCCGGRPKKPKFKAPKDVRTGGRWSSFTSGTSEWVNEKIKLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1C4</accession>
    <name>A0A2T7A1C4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1C4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6557" checksum="AE8A474439213DC9" modified="2018-07-18" version="1">MVVVWWGYDTIFGGVCVCVCVLWDLFGFHFSLVAVDAGLFSRPVGRQSDGVVRTTKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1V5</accession>
    <name>A0A2T7A1V5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1076504</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1V5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1V5"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015512665" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="619" mass="67277" checksum="479B0AEE34FB5164" modified="2018-07-18" version="1">MTSTLGTLCALAALFPAITTSIPLIPRYISENEILAAYDYVVIGGGTSGLTVANRLSEDSSKTVLVIESGPIDDGSDSFKIPYLGRGYLNYGTKYDWNVTSVPSESLGNRTMIIPQARVLGGTSSINGMQFARGAPSDYDAWEELGNEGWNFKSLEEYFKKSENFTAPSEKLSEEFGITYDESAHGFAGFIHSSFPRFLWPQIKNWVGAMKSLGHTVSQDPANGGALQLFWSPSSLDPDTETRSFAREYYDGAQDRPNFHVLLDTTVTKLLTFGNETIRIDAVEFLSSAGATKKSVKVKKEAVLAAGTIFSPQILQVSGIGPASLLKSLGIKVVVDLPGVGANLQGHVYLYNAYQLTNVSLSAANLTTNTTFYNEMYELYKTKRDGPFTNTGSNIIAMLPLSDIGLDNFQNLTSAPSEPFPHSDTSISKGYRAQLKVLLRHLATTSMAGVELSWINEVGGTIFSVMHPLSRGTVTTASSSLLTNSTPTVNTRYLTHPLDTRISIETFKYNRKIAATGEMQVLGPVEVSPGPGVSTDEQFEKVIKEGPNYMYHMTGTCSMMKRELGGVVDTELRVYGVQNLRVVDASVQPLIPAAHLQTTVYAVAERAADLIKAGSAWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2K1</accession>
    <name>A0A2T7A2K1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transport protein Trs120 or TRAPPC9 TRAPP II complex subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1121452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2K1"/>
    <dbReference type="STRING" id="42251.A0A2T7A2K1"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="2">
        <location>
            <begin position="100"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="3">
        <location>
            <begin position="189"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="354" mass="39007" checksum="1D243D1288F13801" modified="2018-07-18" version="1">MPLIPYPTVEVTKTTKSSPSNSKPVTPLPDLGGVPDTALSTSLAKINELLGELLETILNLYTRSANFAGESIPQICFSETVIRFSKLRATTYITALCEALPIKRIFLQNPSHPIPSLSANQRQFVVSTTKVSVEQERQSRESFWYREEVLDCVRGCSEEISTGRPGGIELRGIRLSPRMVETICIEDIGVDVSVKQVEEQVRKIGPAKYLVVTDNFLTLVTTLTNRTTRTVIPLLRFLRALRNQGANCEVAMDLMRRFSFNGLLQQSLRPLEAGEVRVVKIGFVVLCTSKGEFEINASVEEVRRGGSGRDGADGDGHEGVLGPDGISIDVIAKIIGKKTWVSREMCVVVARDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2P6</accession>
    <name>A0A2T7A2P6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_969703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU82012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2P6"/>
    <dbReference type="OrthoDB" id="3141857at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039965">
        <property type="entry name" value="C3H7.08c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40466:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13327" checksum="7558B1942C3BBDB9" modified="2018-07-18" version="1">MSGAVANAGKSVLKQGAKRDPELYILLAVMSGAFGLAGFYFGRKPTSATSEEGRINVAKDGMPWHGKPAETSAGDHFKYKYHPGGDARNAPKDAPSALHSVIVPNVNLPKELHDKYNKWGKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2V6</accession>
    <name>A0A2T7A2V6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1018467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2V6"/>
    <dbReference type="STRING" id="42251.A0A2T7A2V6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="164"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="477"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="919" mass="102236" checksum="F77ADA39A253C551" modified="2018-07-18" version="1">MPDFLFDDGLTNTNPVPANVFSPPPPPPKSKRQEKRERKKVEWDEKNRLRAAQRAVEGLSPYVPDREIDFLKKKRQRETQRHQSPPIISQVGEEERAKTGHHEEQANVKKKRKTETSNDKFPLLDGGVPGPVIQIHQGQLKAQALRLKPLRAKLPIWEHQEAIRAALQEKNVLVMLGETGSGKSTQIGQFLVKERWMARRKVSITFGKGDGNGDEKDKEVMVGGCIAITQPRRVAATNLARRVAQEMGCHLGDEVGYSVRFDNKSSEKTQIKFLTDGMLLQEMLHDPLLKRYSAVVVDEAHERTVGTDLVMGFLRGLVYGKRKDLKVIVMSATLEVEKMALFFERERDAALAFIKAKEERKRGKKNVVEVNENGDGGADGGKLPNGIEKGGGGKKKGKKYEGTSMINGNPYDWKSNKEGSSPPFVNGERKGSVEGSGSNESSSEDFDTEDEQYDGTVAAFKVPGRQFPVEIYHAPEPVEDYVYAALKTVFQLHYGEPLPGDILVFLTGQEEIEALQKQIEDYAQSMDKNVPKILVLPLYSALPPGLQQRVFQPAHEGNTRKVILSTNIAETSVTVPGVRHVVDCGKVKTKQYRPRIGLESLLITPVSKSSALQRAGRAGREAPGKCYRLYTERDFMPLADTTVPEILRCDVASSILTLKARGQEDVLAFDYLDSPGREALGKGLEHLYTLGALNNLGRINELGHKMAKFPLVPALARVLIAAAEPEVDCLHEVIDIVAALSVENILLTLTSDEKREQIEEARKEFNRREGDHIMLLTLVREYESQPQRKAWAEKHFVSHRAMQNLLDIRKQLKQYTNHLTLSPSPPPTPAATVTPDLATRILKCFLKGFLHNTARLVPDGSYRTVVGNQAVAIHPSSVLCGKRVEAIVYHEFVYTTRAFARGVSAVEMGWVGEGLMGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A300</accession>
    <name>A0A2T7A300_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1075815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A300"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="16597" checksum="73CDEBD38EB319A3" modified="2018-07-18" version="1">MPHNLCSDSSSVVSLTGALVGQLGCRNAIECRPASSSAPGILVTIHFRFCLASGFLFAFLSLSETVFLAPLPLIPSSPCLAARTILTQTGHSSPSFTPFLSPTIGLLTNLQPLIESPAQLLAVSLIFFHFIHSFSCLDSVQVKIHLFPSTSFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3B9</accession>
    <name>A0A2T7A3B9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_477723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3B9"/>
    <dbReference type="OrthoDB" id="5328442at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="67591" checksum="957FAC1B163137B3" modified="2018-07-18" version="1">MQSPMALGPTRPSWLFGEHRLEALIEQNNPTIPLSALRASRNECQLVDSVLKQILLEQNIQTTPGEFEMYWAKTHLAMDIQSILKRWCSVGWDKTWESSALRNLCPKVSKQHGDLNMDDATATAAIAPTDAAVEQKARLPISEPSRPIFPEAYAARRQNSYSGWTPCNDPVVQSIEAGAAAAAAGVNSRVYPIPVQPVSKRPFEDSDDYQNRRVSKSKSVNFGDRTQFICPYHAQNVNDHPECANKSFPNPRKLKEHVWRWLKPFKCPTCGEGFGREKTRAIHCDQRKTKCKKMPSTYEGSAEQRRDQKIESAKSTKEMIEIFEEYEREKHNPRDSNSSPSSSNTHNQDKNNNDDDCTSDEHHQVGKYRDGQDDRSSSPESQNASNASVSDGDSDHGSNYTRPNHTASINSREQEQEEDEAGLGLNPHHGFDRLNSDNAQHSLSQDSFQYPLQQPSRGEDESRTLYPYHQHQHQISPILRSSSDMDYSTSSTSNAITNLLLNIPEIVVTEAEPQIKSPTVTRSSDPNPYAQQNIYYPNPTSPDSLYDHHRDGNFRGGEEEGSPDTEHVPYGINSRGIGQGYGATPLISAGYGSFGSMVFGMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3C3</accession>
    <name>A0A2T7A3C3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1099322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3C3"/>
    <dbReference type="STRING" id="42251.A0A2T7A3C3"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="636" mass="70521" checksum="2B401E4B73C6A7E1" modified="2018-07-18" version="1">MTPYSPSSNQFMDTRSEPGLSDVPSTPIATDSPGLPPISPTFRRTPREPFQTTAQPQVPSFPSILESSFGHGKLVPLAPKNPVLEPLDAGSDDRMELDFEEPIARVYNPSGIKPSGGPSGDSTAIPGAKDREPEATISNNRSMKRKRRISEIDRMIEKLTSEKDKLVYEEQVEFNRGNYPTQSQRASQDSQAVVSGPNGPNSKRIALGRIEENDQDHDMRGGNEPGVLPDSERSGTSHALRGYIQQATTQDPWPGRWLNPSTDPHSPDAADKDRASALSPQGTMTVSSPTGTTAATEVSQQPHPAEGRLRLSPPLAMGLRAQRGAIPNKQASSKYTGNAAQLRLGPGPSSGLQKGPATCLVCAKTFHRPSELKKHMKRHSRPFACTFRGCGKSFGSKNDWKRHENSQHFQLELWKCGVIAPKSTGLCGKLSFRRESHITHLKNAHNIIDKQEIQKWTNEAHIGRNNFKTFWCGFCPKERGGLIIKGCVVQLKKKGLDGWDERFDHLGKHFEEGNHIKDYTFHEDDVFGDLHSTEEDEDEDDEVDDIREEDDNTGEERPIIESTAPPEEEKAEKLQPSQLATTQKDEKGNKKDKRWYCCNQNIGRCSDPGPYTVGLTDSCIQCCHERCKACSIEERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3L4</accession>
    <name>A0A2T7A3L4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1099278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3L4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3L4"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102:SF2">
        <property type="entry name" value="GAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43102">
        <property type="entry name" value="SLR1143 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52585" checksum="B68D88E4AAE66842" modified="2018-07-18" version="1">MKPLRSLKPSMGSIGNTLIEVKVLALTCCCQMSRWSYWMLQRCDWRLKGNPLVKSAPYIQFYAGAPIVTFDGRIIGTFSVIDDAPRDSFGVGERRKLIDFARHAMSEIDSVITERDMLSRRAPALVDLRVLHEQAQQSLVRDRPKASRDGTPVSPKSSPKPARSPASSRTARKRDAPIPVNRPVAIRPGGRLPTINIPVEPEHGRNNRTSAKISDMPTPPHTPSRPFSLTTNNSRPLNLTAPPNSVNETSSQGALEEEPADHQARHKQRKPLPPIQTPGPREAPLQIPFSSGPITSLAEPSFATSIIARSLNYDFVYLLRVSPVTSQEPRILPFKQEYAGNNFHTKVLVAHGLPNPLPVFDANLHLRALRSAGGLVYQNPARSRDEDDVGFRSGILLPLLRDGIDNSPDEGYSSATTTTGNGFQQSETACTGGIVLAAFTREDGRDSLPPFTADEVRCLREFGEAMKDILLRVDRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3M2</accession>
    <name>A0A2T7A3M2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000030">
        <property type="protein sequence ID" value="PUU82314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3M2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="63" mass="7010" checksum="64CCBB1AD34A239D" modified="2018-07-18" version="1">MLDFEESDTDGEGEVQDYMDKEQKIWGYEVQKNSGARGGGMSNRAGSKILVRHRDVRGSDCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3R3</accession>
    <name>A0A2T7A3R3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_426765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3R3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17675" checksum="C938553003ABAE49" modified="2018-07-18" version="1">MEVWASKRYQRRGGGERPPNHRPAILTCSTVIYELHPKEAAFAATMLRKREFDYLNPNSTSTRRKRHKSPLLRVPGAALCPSHQLQNLSTDHHSTFLSPLPSFLLFPCNIIGSLLFLLPHSLLVAPSFLRSKVKRYSNPIIPLFCYHPSHSNHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3U9</accession>
    <name>A0A2T7A3U9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_415398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3U9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12790" checksum="4B44504118491552" modified="2018-07-18" version="1">MDTVLYREAHWHAIQEPQRVRLGGLSACYSSKSVNFLYRTYYYKPFYALLFPTGFVSSLPTTIIAFLCPPTAWLSSTFPPPSNILFHKPFKVLVYACVCVWGLSFPLQGPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4G5</accession>
    <name>A0A2T7A4G5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4G5"/>
    <dbReference type="STRING" id="42251.A0A2T7A4G5"/>
    <dbReference type="OrthoDB" id="10655866at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="252" mass="26035" checksum="254B096C8AE5DD36" modified="2018-07-18" version="1">MVREVEKVVGNAIVNHWLPGEKFLSYTSSSQIPLCSLYKNLFHTNHLNQRSLLDRHYHPSYCSSQLQLRGPLQLPFYQPFSYSSSYLSCYILSYPSSNPLGYHDLFYYLSATSSATSGANSPSNSHSNSAANSSANSPANSPANSPANLPANSPAISSANSLTNSPANFPANSPANSPENSPATSPATSPATSPAASPAASPATSPATSSAAPSATPSAIPPATLLTISPATSPAISIASIYLATQATSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4M1</accession>
    <name>A0A2T7A4M1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sodium:solute symporter family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_346950</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4M1"/>
    <dbReference type="STRING" id="42251.A0A2T7A4M1"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="49935" checksum="E504CE5B99BF5F2F" modified="2018-07-18" version="1">MGSSILFSYPEIGTIAGVQGAITYAACSALPVLSFAFLVPKLRSKLPGGFILTMWVKERYGLYAGLYLSFLTVATMFLYMVAELSSLQQVINALTNLNGLPVVIVEVVITSIYTSLGGFRISFLTDNIQGAIIAILITICTIAIGTSVDIDRSKIGPSGLTHDTVLGYQLIYILFIGILFSFMFLSNFWMRAFASKTDKDLWIGASISAVVLFIVLLLVSSTGFIAAWAGVWKPGTYGGLAFFLLLAELPSWVVGFTIVMVVALSCAVFDSLQSAMVSTISNDVFKNKLSLLWVRIFVLFVSVPAVVVALKSPSILRIFLISNIFSCAAMPPILLGLFDAMYFLRGVDIIVAGFGGIFSVFLFGCAYYGDAKKAADLIILTSGLYADDWSVFGVFVAAPVGSLIFLMLAVTCRMGCVWVRCKIKGGRFDCLDKPLPREDVVGERDGSPGGSLEDVERRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Q8</accession>
    <name>A0A2T7A4Q8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival motor neuron interacting protein 1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1074360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gemin-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Q8"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54369" checksum="11FE02AB9C393DD9" modified="2018-07-18" version="1">MTKRKKRGQNKTRNPQNNNGASSSYNNNHDNGANKRPRYDFGGNGNNNNSGFDFDASKGYIDPTTGQRGAFPGLEGEPDDFYGPANDGMDYLRMVRSEAKGVPTLLVTGQKVRRPPPLPILRSDTLNYDDDEPEVIEQVATELEEGEIVEEQEEDDDEQGWYNDGAYTAAMDPTIATPLAEPPTALSLWHNALLASFRSVRQSLHVNPPTPVLPLAVSPSLSARKQRSLWQQHIFNTHPTPKELWGIDQQTVLRLLKWLTQRMSEMAKHKNGRCWSQWLWGLLVRLDDCLTADETSIVRELGKRCLIIRERMATSLQGGVPDDQKEEEAEYEDEEGNEGVQELNTVQGGDTVAAAATQQPEQTLDSPTTPKVEEIVKSEVTPQRGVTLESIPLFQVEKPAETKEAGGLELASRLRTTLQSIKTRKVQEGPLQSGQEHQPKPNAPVLQTADALSQSDTFAVLDMVISLVGDFYGQKDLLSDRKAPIHLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5J7</accession>
    <name>A0A2T7A5J7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1073647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5J7"/>
    <dbReference type="STRING" id="42251.A0A2T7A5J7"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="142" mass="15984" checksum="2B2200A610971746" modified="2018-07-18" version="1">MGIPPPEAQQMQQKEQSWGMWWKALHVLSSLCLAGWVLRGTGWSFTGSALERAESASMTREEAPPLFWYFTTMELILQSSRFFLEKGRPPPGSWLTRIGGFLPHPFGTSLATIARYSVIWTTLIADAGVLIFCLGMVSWWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5M0</accession>
    <name>A0A2T7A5M0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase/oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1119918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5M0"/>
    <dbReference type="STRING" id="42251.A0A2T7A5M0"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="236"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="355"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU82965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="685" mass="75611" checksum="BDCD2965098F78FF" modified="2018-07-18" version="1">MSNTGKKSTFTGPPQNQHPGQHSQQQHTHQQQQQPGLRPSSGDTGFFQDAPRLGNQFEEDVGLKRVLSLYLPPALLKPLHKELDSLAVAALSPQVLHWVEDAEAHPPTLESHDAFANRSDNLRTSEGWRRLAELGAHQGIVAEGYEGRYGRIGQFAKYYIFSPSSALTTCPFAMTDGAARLLSQHIPHPATSIQSFFSLNSSLSSRREAEARRQVFHNAHFRLISRDQSARWTSGQWMTERPGGSDVSRSETVAVYSPLAPPSQNESGTEELGPWVVDGYKFFSSATDADMTILLARTPGGGGKLSAFYAPMRLANGERNGVRIMRLKRKLGTRALPTAELELKGMRAWMIGEEGEGIKQMATVLNITRVHNAVSAISFMRRGLAIAKAFSKVRVVAKNRPLWTIPLHLRTLAHLELFQRATTHLTFFSIHLLSLSEAPTNPSTPSPSASSPLHTPSAPHQLLRLLTPIAKALTAKLAMSTLSECAESLGGVGYCENEEPLNIARLLRDAQVLSIWEGTTNVLITDLISSLKRTSRAGGEEQGWVPFNEFVEENLGSPATATTGRVGEVEAEVLERCKVALWGEWKEFEKILETRSKEELTGGGRVVLWTLGWVLCGVLLIVDARRDGERTAVEFARRWILEKAGIWGAWGEHGVLQAEVEKRARADCWAVFGEKLPEVKDRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6J3</accession>
    <name>A0A2T7A6J3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000014">
        <property type="protein sequence ID" value="PUU83361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6J3"/>
    <dbReference type="OrthoDB" id="10501944at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17488" checksum="D2BA310914C9C165" modified="2018-07-18" version="1">MSGSNLPTYTSSSSSSRNENAIPQSPNSSSNLSKALRNTIPLNSGPPALSCPVSGCSMVFKGEIAHEYLWRHLKRPGIHRRAGDEKTAWLNLHKIEHDRLLATRLTRAQRRRETNKVKAQKMLRTAELEQRAKSMGITEKALVAQKVAIWEGMRSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6S2</accession>
    <name>A0A2T7A6S2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6S2"/>
    <dbReference type="OrthoDB" id="10478951at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="17651" checksum="E9FEBA97E5393F7D" modified="2018-07-18" version="1">MKTQREKMSLNLSPLSSPKYRQFLVSAIHFEFLALLWLITLLPIPFTAVLLTSEKRRYALALHAISVVVLMLITMSYALYYYRMVRIELEDMEDRRQIDNWEEAQLKLQLQIFFEERLGSSYNGKGRKVGLVPLVKVPEKAWVGRRERVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Z6</accession>
    <name>A0A2T7A6Z6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LEA domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1105157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Z6"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Z6"/>
    <dbReference type="OrthoDB" id="4023585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14291" checksum="C81F7359F785E18F" modified="2018-07-18" version="1">MTTLLRLRLPLRLPKPTRTTLTTCRRHLTTTPTLSRTITDSAKDAVKTIDRAAGTAALKGIQTGEAIAETAKRTVSGATERAEGVGGEVAGKAKGTAAEAAGKAKGTAAEAAGKAYEVGGKARGMKEEAKSGNLRPGAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A795</accession>
    <name>A0A2T7A795_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_897916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A795"/>
    <dbReference type="STRING" id="42251.A0A2T7A795"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31151" checksum="CEECEBC1B9380AD8" modified="2018-07-18" version="1" fragment="single">LNSKAKAIDPNGDVLITFPSTTTKLLVWAKILSVTSPLFEKIFLLHQHNTPELVEIGINGHSPEALETAFCVLHGLHQCVSTNLSPDTLYGIALAAYRYCFVSALGPWKEGFKEECRRVVLKSLGDIGDEGEREIGWDANVVPKRVYELISKERISTIRSLLLVAEHFRNIYYNRNIKCRVFIPPPVSKASDTHCLSSCDLSIFGSLGKYHHIIGILPVPQSPYKGISVENLAQAMKALPNVVDGSDGHGKCSIVGSVVRLVDEVLARLDRWDIGDSTFSTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7B3</accession>
    <name>A0A2T7A7B3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_822952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7B3"/>
    <dbReference type="OrthoDB" id="5418749at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14252" checksum="C6E45754AC8AFFDE" modified="2018-07-18" version="1">MISQKTPSSTTAGDISIMSSPTSPGFSSSATYNYITPPMCTKWQDRLIAYCKEHHLSEPLFQDFSDRRGGRTAWTTMVTIGSRVPEPLRIWAKFSYEVTYVNNAREDAAECALQHLQGNHPLGCACGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7N1</accession>
    <name>A0A2T7A7N1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1038618</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7N1"/>
    <dbReference type="STRING" id="42251.A0A2T7A7N1"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="224"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU83729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="500" mass="56854" checksum="1A3855A9DF414B39" modified="2018-07-18" version="1">MATELAIRVLQSLNDAAELPLASGEAFPDVESTVLKGALDSLQSREMLVYETLDREEPVLTEEAEGIVRDGSHEAKVYQAVCAAMDGIKISELPRIVGGTTAKVGQGKAFKEGWITKDGDRLLKKASSIRDTTRDQLQLIKAKQNMPEPALLAELKKRKLLTVQKRISFKINKGPKFALEVVKEETDLTAEMIASGAWKDKSFKPYNFSALGAHTLSGALHPLNKVRSEFRNIFFEMGFTEMPTNRFVETGFWNFDTLFVPQQHPARDLQDTFYISDPAIADKPRDDETGEFLAEYWENVREVHQEGKFGSLGYRYPWKEEESLRLVLRTHTTAISANMLHKLAKNPRPARYFSIDRVFRNETVDATHLAEFHQVEGVIADYNLTLGDLIGFMQEFFQKMGVHRLRFKPAYNPYTEPSMEIFGYHEGLGKWVEIGNSGMFRPEMLESMGLPKDMRVHGWGLSLERPTMIRYKVNNIRELVGHKVDLNFVESNAAVRLDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7S2</accession>
    <name>A0A2T7A7S2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1098440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7S2"/>
    <dbReference type="STRING" id="42251.A0A2T7A7S2"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="337" mass="37419" checksum="42D5DF9689C973D5" modified="2018-07-18" version="1">MNPIRFPKRDSGSSVEEKDRIVQQTDQDASQSRLSAVEAGYLEDPFAKLFVAGEVQRRYPLINRGTYIRTTAIDKLVSNFLSSFPDTPKQIISLGAGSDTRFFRIASANPSVIPTLTYRELDFRAVTSRKIASITTSPALQSLLSPEDLSVDQVNGSLTSTHYSIHPLDIRTLHPSSDFSASIKTSLPTLFISECCLIYLSPTEADAILKWMTTDFSSSVGIILYEPIGGDDAFGRVMIQNLAARGIVLKTLKKYSSLERQVERLRVLGFTDGQLAVNVKGIHDGWVSAKERGRIAGLEMLDEVEEWDMLAAHYCVAWGWRDRGEVFAGWRDMGQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7U6</accession>
    <name>A0A2T7A7U6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1071662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclear serine protease which mediates apoptosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S1C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7U6"/>
    <dbReference type="STRING" id="42251.A0A2T7A7U6"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="301"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="865"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1005" mass="111570" checksum="E66C34ADA0CF9615" modified="2018-07-18" version="1">METNGESRAKRKYPGSPPADRPTKHLRDDSFGTDQDEIDLPGGEELGFVALDTRLLPPAVATHDSAEWQKTIEEVVRNVVSIRFCQTCSFDTESAITSEATGFIVDAERGYILTNRHVVCAGPFWGYCVFDNHEECDVYPVYRDPIHDFGILRFDPKAIKYMPVGALQLRPDLARVGAEIRVVGNDAGEKLSILSGVISRVDRNAPDYGDGYNDFNTNYIQAAASASGGSSGSPVVNIDGYAVALQAGGSIEAATDYFLPLDRPLRALECIRNGRPVTRGTIQTQWLTKPFDECRRVGLSPEWEAAVRKGFPKEIGMLVAEVVLPEGPAHGHIEEGDILIKVNGALITKFVDLDEILDNSVGKKVRMLVERGGKAMDIELDVGDLHAITPDRFLTVCGASFHDLSYQSARLYAIPVRGVYVCEPAGSFRFDGMDKGWIIESLDNKKTPNLNEFIEVVGNIPDRSRVVATYRHLRDLHTMHTSILYIDRHWTTKMRMAVRNDVAGLWDFSDIADPKPPVPLAPSSAQFIRLDNVGYPAASDLVRSFVRISCVMPIKLDGFPRARKTGFGLVVDAEKGLVVVSRAVVPYDLCDISITVAESIVVEGKVLFLHPLQNYAVVQYDPALVKAPVQSARLSSEHITQGASAMFLGFNQNLRVVVAKTSVTDITTVAVPANSSAPRYRAINVDAITVDTSLSGQCGSGVLADADGTVQALWLTYLGERTHSNKDVEYHLGLATPSLLPVIRQLQNGIIPKLRMLNVELHLVHMSQVRIMGVSEEWIRKVEQDNPERHQLFMVRKVECGHSQTLEEGDVILSINGKVMTRITELDVMYDHEYLDMVVVRNCEEMMLRVPTVPTDDLETDRAVIFCGAVLHRPHHAVRQQISTLHSEIYVSARTRGSPAYQYQLVPTNFIVGVNGVKTSDLDSFLHEVSKIPDNTYLRLRIITFDNIPFVITIKKNEHYFPTMEFIKDPSEPCGWRRQTYEGRFTHAGLESNILAENMDELGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8B5</accession>
    <name>A0A2T7A8B5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Anion-transporting ATPase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1071192</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8B5"/>
    <dbReference type="STRING" id="42251.A0A2T7A8B5"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="334" mass="37089" checksum="ACC0B092B7C5D31E" modified="2018-07-18" version="1">MSSTFVDSDLDPLEPTLQSILDQKSLRWIFVGGKGGVGKTTTSCSLAIQLAKVRESVLLISTDPAHNLSDAFNQKFGKEARKVEGFENLSAMEIDPNGSMQELIEGAEGSQNPLGNMMQDLAFTIPGVDEAMSFAEVLKQVKSLSYSTIVFDTAPTGHTLRFLQFPAVLEKALSKISQLSGKFGPMLNGILGAQGGPGGVDEMMQKMEGMREVIGEVSKQFKDPDLTTFICVCIPEFLSLYETERMIQELNNYQIDTHSIVVNQLLFPQKGSTCEQCTARRRMQKKYLEQIEELYDEDFNVVKCPLLVEEVRGSDKLRKFSEMLVKAYEPPAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9R0</accession>
    <name>A0A2T7A9R0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9R0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="17993" checksum="672270ACAAE2D8B0" modified="2018-07-18" version="1">MSASTKIWATMNTFGKWAQKNPTLTASLGGTGLLIASQQYGRWSIGADINNLRCELAAIDSKITAISTSKLADLQPRQEFTKRPVFKMKAIDDDKTEMGECVKDGEKPSKCIIELEDFPGPEIIKKCMKEALSRVHPGEDRPEVDNCGKAEMGESVEGVEELGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA48</accession>
    <name>A0A2T6ZA48_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1137913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000565">
        <property type="protein sequence ID" value="PUU72343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA48"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="92" mass="10073" checksum="4DA04E9ACCA9192F" modified="2018-07-18" version="1">MAKKNKTTKALDLEKTLRGSERSDTHDTGTETFYGQNTYGTLNMPPTSQVQVAFLTLNGYPIATIIAIIFTIFYNSYRGGLPAQPASDALPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAF4</accession>
    <name>A0A2T6ZAF4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_915619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000528">
        <property type="protein sequence ID" value="PUU72482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAF4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAF4"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="19437" checksum="9A6F8D5D4AE480A1" modified="2018-07-18" version="1" fragment="single">MAAPPTITSKNLTGKFFMNKTLSDDLDEVLMEQNIGWLTRKIISMATITLSIKHYTEDDTEHIDIDQTATGGLQGTTEIRILDWKQRPHQDHLFGELTGQSRRVQLEDVQDEFLKKGWLEGEAREDGLVEAFVVSSVNGWSARLIWGFQEFDEKRHYTRHLRFEKGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB91</accession>
    <name>A0A2T6ZB91_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1136849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000474">
        <property type="protein sequence ID" value="PUU72739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB91"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB91"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="37189" checksum="DD56C15A6912178F" modified="2018-07-18" version="1">MSTPRQFCSNLFLASTHDFKTLPKRKPPGRDRATIVPLPPPPKPEKETGPSDAGSSEGSSSSSESESEAEAEDVPKPEASSDNPTEQDELSPDEPPPPTAPFNPEKPALAEDTEATKGDADLPPKSPTIHRRRDKDDYTLLLSLTKDRSAKIIDRDDGFEKRWIWRCGRCRLIVGYQLDDAHFSPTSNTHPNTIAMTGVMGGDAGVDKDRAEKERKRAERKRKRYLYILPDACVSTEELGETGARPSRDITLSRDSATSQRADGMVANAGLISTALRVGDNRKLDELRTVKGCDRGKSPGLEGGGGRRKPSSVDGQAMAASPAQQSVGTGIAGAGESGQGLRHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC76</accession>
    <name>A0A2T6ZC76_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1069268</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000414">
        <property type="protein sequence ID" value="PUU73083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC76"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC76"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="548"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="PIN" evidence="4">
        <location>
            <begin position="1024"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1253" mass="140186" checksum="7C44DFF2B4776790" modified="2018-07-18" version="1">MGGAGHGNTNFQAIDIGSKIVENMRRQNKDSYECNFCHNMVFSMERSLWSHITTDHREKCPQDGDELLRFRTHMKEICQRKGADALSRPENIQTSPNNSNTFIRWSSKDASKDVGGQKMGRKVEPGDQTGPPAYSGGNVDDIANGTSHITLEHPDIQMADASVQARLVNRKRNGPDSATDGGPPTPTHNTHRESQSKRTRGGTSGKGAGNRGPLGNPGFPNDSFHADISSGRAAHKPLRTPLDPDFDRSRFKTEQYGDNEGGMVTRVTAPSRRLFDPEKDHPGAFKGEEDSSKRLEEPNLPPRALSRPKGSTRRKAPVLYTPAPSRKIAVPASQALTLNREGGQMMILENFAQSQPTQPPQGRQTRPPQFYGGSTLEDNETRMVRQPETRPISPEQLIAEVKGIYAGLVMVEAKCAEVDAKQAAATFDDGQPQPRLNDEQWQALIALHRTLLHEHHDFFLASQHPSASPALRRLADKYAMPARMWRHGIYSFLELLRHRLPMMALLYETVPAFEDTWVECLGDLGRYRMAIEDDDIRDRDVWAGVARFWYSKATDKTPYVGRLFHHLAILARPNVLQQLFYYCKSLAVTQPFYPARESILTLFDPIFSPEHANKNHHHVDSGFIQLHGINFTHIDLEKFDDALFDYLDNLDQNIGKTESDWKYGAKESLLRIALREGKNRLIPEEDMEDAPPAAVDENPAEFDSLLPPLPTGASSEHVTSMLQPASKLEEDSRYPRKANVKSGSQAIEADAKSRNGTAESLSFSKRLAYEILSVALQRVGDSNVLPHIHIWLVFLAYVVKSEPAIRLLENEFPWEHLVYMLNSLVGQSDQDRFGCKEFPVPEKGRGRPLPEDYTLRGLEWARKYFPNRWFEDAQVDEEERSVEVPSMENVRIERILWLAAQVAANGECLVYADKMFRVHPALVTRIEEHQKLEATTVHKQELGGSRMTPTSEDSDVEMTSGENESEDGEYVLVGQSEEVRRLKQQQRQLKSQLKACGKAADSAEEPKRAVAKGPESLKENFSVLVVDTNLLLSQPEVFKLMVSTFNWPIVIPNTGMPILITELLGLTNSTGPVGDAAKAAMIAINEALNDKRDVKVVTAKGSNVTNIGFYKEQLDKPRDDEQRKIDDIIIETTKLQGEARRQAIPGDYGDYEAAVLITEDRNMRVKANARGVTAISASALKKVLSPRAGLARPKRKSLGAPTTVPDWPDDEMTFMEPGEEFDSVLNVNPIGTVRKKRQLKRGKPQGADLPKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCK5</accession>
    <name>A0A2T6ZCK5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000407">
        <property type="protein sequence ID" value="PUU73176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCK5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCK5"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="26242" checksum="43D89AD79DD1DA4D" modified="2018-07-18" version="1">MDYFPQFFNFSIPADKSHPLLPPEIEIRHTATKDYSLFVVSDIPTGTLLFCESPLVTINHDSTPLDVLIQKSLSVADPHTIRCFYNLHNAHHRWNDPSYILTHKPAIQAGIWLTNCVLLSPFTSAVFNAVSRINHSCIPNVELEWSEDRQLMGVFAKRDLAAGDEVFRSYFEEEVGHRLVQVRREYLRGGWAFECGCKRCVNEAAYWDWKNKPSVPGDNEDVEGRMGSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCP3</accession>
    <name>A0A2T6ZCP3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1111360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000406">
        <property type="protein sequence ID" value="PUU73184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCP3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCP3"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="16"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="241" mass="25995" checksum="93BFED6164425DBB" modified="2018-07-18" version="1">MTTCADEKPIPTTFGVLLFPGFQALDVFGPIDVLNTLALSKKLNLHIIAETLDPVTTKLPQPNTTGSEFHECIVPTHTFATVPPLDFLLVPGGLGTRAPGLDPTRQFVKNIYPSLKYLMTVCTGSALIAPTGLLDGRSATGNKKLWAWVTSQGPKVNWVAQARWVVDGNIWTSSGIAAGMDAMYAFVKYIWGEEQSKDLAMSLEYERHTDPHWDPFAEYWGATWPLTPGAGSGDGSAGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCQ3</accession>
    <name>A0A2T6ZCQ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1135540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000396">
        <property type="protein sequence ID" value="PUU73249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCQ3"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="4">
        <location>
            <begin position="316"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="639"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="567"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1436" mass="160045" checksum="3C0D3B4DE3180B99" modified="2018-07-18" version="1">MPLLNPYLRAFFRSTLPAQCTPIQDHILLVPTTDILTNTRDRETGSLYSDLAGLDEFLGSHVLRIPSGGSASPMVGSRENRGKARQYTTFNGRTVVVKDSWIYSNKGFRSLNQAQLLNDALFYPDTNEPQQWLIYYISKPLIGSLEPVPAVPALLRDRTNTEPPVARTSGPRKKDIKSFNELLMLFPMIARQMQPGLEKLFQEFEISFQKFKPLPLPPPSPRSVASGHSSAKNSIHSSGNGDVYKQAADESEIRRSLESAIMSAVDLFQRVDQSQLNLLATSTELTGPAVDRLIERYVAEQLHDSILFPRICATKSIEDEELEQKILDMESVDLTQVGIPLLDHQGTKSLIKRLNRGIKSFEHIGDSKSPQAMVQHLLETAQTLTRMEASDIQDQEETTSSSNPEKSTVVTMNADMLVSLLLIVVIRAKVPNLHASLSYMRNFMFSEDVEQGETGYVLSTLEAVLFHIAQDHALSAASRSNENLWRSVRQGDLETVKRLLEPGIQSAEASRSRENSAIGSKVSNESDDEAGESEEESGNERGRSPNPHLTIEIHSPATQHPNQPFEESLRKGASDRAAKAINDAASDISEPVEDEESALPSINKDATAGLDGELPDSPFASPIKAESVPLSNGVSLAIDAPEPLPNMTAGTEDEEITLPNGIDPNASSLDTPDEEAYTDPFEAAATDSSSSKSIGVSSVRLEDLRADGQEDADFLNNILLPPTLKVTPNIRTGTTRFKFDERPGNARKTRGRSVASLATTIDDTSTSSLRRLSRTLTSQSQNADSFSAEKLCKTRNAQGESILMMAVQERRVHVLKYLLSTPLFDTEFFVEDTNNEGTTLLSSAVQAESTDILALLLPRVLSLPEEMQRKYFQKADSAGRTIAHYLFHTPDLISRLGRWLPWKYKDKNGQTPLFALCRSYDHAQYKEMVQAAIKNAQHAQRDGCKLHLDEHVDTKGNTLLHIASDPTVLRTLLRCDSGVNATNNRGFTALMVASKYGRVEAVRTMFGDPRVDLSAKELRGLTAVELAKDDDVRNRIDDLVLFQNPPMPDGRVTAVVRSFFVEDATIRVVVKSGAPSGDSTFMITTCRRSLTDFQFLAEWLAYENPGSWLPTIPVPRSPYQIPSKPSRSVLRDIQLRLDWFLKTLLVHSTFSTHELLWEFFLVPEIQQSLMIERSKKKAEARMEKIREEYQPIEDTRDVEVFVTHAKDSVRSINFACRSVTRRANAIRTTLFDFSDAFKLCGKHISGFSFLHDTPQLASFHKFSEILIPSESNPYTLFLEDFRNLQSSLNGVMTALDRPRQLINQMSRLQKQVDKHINSLRRSDRWPLGLLDDTRAKIHQEAADNVAKSKEQYLTLSSELRYTQTVAAGELSSFHELHAKQARRAIRELAQRQLVTEKAKLEGMRRAIRIISMKGGGVAANAPLLPPSRTAPPFDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDN2</accession>
    <name>A0A2T6ZDN2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RecF/RecN/SMC N terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_527793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDN2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDN2"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="7">
        <location>
            <begin position="302"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="492"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="566"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="709" mass="78235" checksum="CFF86A0E2E14B8A8" modified="2018-07-18" version="1">MSSVTPARPSRRAAASRRTKKVVESSESEAESEAPVKEGDYEEAEEEEDEDETPPPRPTPRRKSRRITSTPAPAVAPPRTTRARRTRSGAEPEAPSSAAPKPRAARASRKKAPPKLKTPEIKDGEDGEDVLDKEQVPEKEDTPMQEDTPMEGAAPMEGDTPMEGDTPMQGDTPMGECPMEGPTVQKQMPRPSATPAQLLSQALGPTGQLRTPSPTPSSRPTPAVAPPLAQSQFEATPTTPIKPLEEMVTSSMAGGDAVTPRPTSSYSNSSQNPPVIVKSRANALFQQQQLEQEQGPKPRLVITHLVLMNFKSYAGRQEVGPFHASFSSVVGPNGSGKSNVIDSLLFVFGFRASKMRQGKISALIHNSAAFPSLDYCEVEVHFQEVLDAAGGGHEVVPDSKLVVSRRAFKNNSSKYYINGGTSDYTQVTTLLRGRGIDLDHKRFLILQGEVESIAQMKPKAQHDSDDGLLEYLEDIIGTSKYKQPIEESATQVEELNEICVEKSTRVQHVEKEKNSLEDKKEAALEFIRNENELTTRKSALYQIHIADSTANINVTAEMTTQLQAQLDEELEKHRGNEDEIKKLERKYKAGSKEVEEVEDATKAILKELAKSEKENVKFQEKEKFLTQKQKKLQKTIQTNRLAASEAAATIEKHAQDLERFGKQIATLETNLGAEEQELDRIRDTLKENAGIFGSDRRQAKDSRAVERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDX5</accession>
    <name>A0A2T6ZDX5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000354">
        <property type="protein sequence ID" value="PUU73693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDX5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="301" mass="32635" checksum="E252BD0FD262F2AE" modified="2018-07-18" version="1">MALQNSGGIRHPIMEFFDHVVQRHPVCPPPKGHLHTTIFHGATEFSGGGRPGSGSVRNPIAKPFYDVVLRLPSVHHQKGVLIQVLGVLGMLSWSPFPTSFYAIPSVHHPRGVSIRGFSIALLSLLKGGVLMLGSGGVRNMIMKPFYDIVLRHPICPLSKGRLHTTIVYGATEYSGGGVLGALGLLSWGPFPTSFYAIPAVRRQKGVSTQVFFMALLSLLKGKSLCQVFLDVRKALTLKPDSRSIRHAITEPLNDVVLRYPIYAPPKGRPHTSILHGATESPEGGIIMPDSGSVRHAITKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZED6</accession>
    <name>A0A2T6ZED6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000340">
        <property type="protein sequence ID" value="PUU73839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZED6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="302" mass="32923" checksum="4F4B5B6DC18AB5C5" modified="2018-07-18" version="1">MTSEGDNKYICPRCGRSKWRSPLADWVVTKDYYATLDPVCCDYATDSDDEYTISGSEGDEPFTKDSSRSKGKGKGATSMSSSSQDIYTHKRGSGKTLRDVSGGGGYYLGPSTYRVSFSDSDGDGYPSSSRHSSSSRSKHPSSSGKSLSGLSHRDSSYDSEGSRTTHRTRHSGHDLPVGGHHNKDSGYQTHRRSSSRHRSSKSTGSSSKVHSGAHLSSSDGVSEGYQGRSRLPGSSEHERPSYSSRHRSRTGRPESRGPRDRDEDSQPPPYSAQPSSGGTSGGRRRRSERRKLGRVEEDEEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF29</accession>
    <name>A0A2T6ZF29_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF29"/>
    <dbReference type="OrthoDB" id="2386090at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="12115" checksum="6CC55FFE0C6539BD" modified="2018-07-18" version="1">MHAYLYLPPWARHPTNMVRRYVDKLPADARLDLATIRLLGRPKITTVKVGELSVTRKRMGSINWEWKNPSTNKPQYFYVEEAGSPSNVPIRGDRTGHSITYFKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFG4</accession>
    <name>A0A2T6ZFG4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1001165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000312">
        <property type="protein sequence ID" value="PUU74237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFG4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFG4"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="494"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="715"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="965"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1093"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1195" mass="128807" checksum="D8A92AC4B323CFFD" modified="2018-07-18" version="1">MSDDQPPTDKQTPPPIPHQSSHEGGAAHQSNYNTPPPAYSPLPSIDSVPVGPLVRPHHPSSTDGQSEFSSELEGDSASSPPLASSETYGEIDTEQDEMETSAKITDDGRINININQKTSTLSSLLAPAMRGQLALAEEAKDRVRHGKPIDLPVPGFDIPEFAKNVPPLNILIQIIGSRGDVQPFIALGQVLKTEYKHRVRVATHPTFKEFVEENGLEFFSLSGDPSELMAFMVKNPGLMPGFDSLRNGDVTKRRKAMWDVLVGGWRACELKLDILGIEPGDGTSYSLDSASSRAKPFVADAIIANPPSFGHIHCAEKLGVPLHLMFTMPWSPTTAFPHPLANIQSSNAECTVTNFLSYILVEMMTWQGLGDLVNKFRRGKLGLDPISTMWAPGMIARVKVPHTYCWSPALIPKPLDWPQHISISGFFFLSLASSYIPPPDLANFLASGPPPVYIGFGSIVVDDPNALTDMIFAAVRKTKVRALVSKGWGGLGSDQLDLPPGVMMLGNCPHDWLFPRCSAVVHHGGAGTTAAGVRCGKPTVIIPFFGDQPFWGSMVAKAGAGPEPTPFKKLTADILADSILMATSPQTQERAEELGARIRDEKGAEVGAKSFLSLLGGQPGEGGVYRCMVDNTKVATWRVKATDVPLSSRVASILVKNGKIEGGWNGLKLCKHKDWDTDTSPMEPISGATGALIGTLGSVMMGLGDFPKGVFKQFRKAKPQNSSHSEEISSPSSSLHSGNEKASGSDIPFAAGSSTTAGRGKDSSRELTCPKPGESETGFMNLDAAVGASRSVSQIVGAGLKSPMDFTLSLAQGFHNAPRLYGDNTVRPLDKITGFHSGLKAAGKGLGLGLYDGVSGLVTQPLQGAREEGASGFFKGFGKGIGGIVLKGGAAFWGVPAYTMKGIHREIQKLQVSDVDKFIIGSRIAIAEAEFQQSSPQLQQQTINRWHELGLNKFKRVKDKRACSTSFPSRSLKSKGKGRESPDVEAAPQSVIGSFGDEELEKAIKESVKITSNGDPGEDEMVERAIRASIAELQGGRSVSIHGAAGSNSEESEEEAYQRAIRASAAEAERNNGKNVPKDPILEEALRNSLLEGGLGHNAKADTQDEELEKALRESVRDEKAPAREYSDTQDDIGDSELQRAIEESKQLEIDRELRRKAEEEVIMEYVKKASLEEQEYERRNKRRSWVDEVGPSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFN2</accession>
    <name>A0A2T6ZFN2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFN2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="85" mass="9350" checksum="E2BB751395746FC6" modified="2018-07-18" version="1">MSTPNLLRRRTIILTVGAVAITAVGAYTGAQLKSDLQAKRQKEISGEGIDGRIRRWDIFSLSLFDFTSFVEGANCGFLVLVFDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH06</accession>
    <name>A0A2T6ZH06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1132671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH06"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH06"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="5">
        <location>
            <begin position="270"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="478" mass="54309" checksum="C84BE205682AF804" modified="2018-07-18" version="1">MSNPPPPSEDPVAWAKHLTGAFTDAIHKKRAECLTKQARNLSLGSPPPPLRPPPPIPSDSPSPSRPYMRPTTSSSSSSSSSSSQPGLRKAKSKFTLTTSSSRSQEVGPDGLPAYTRSGATKESHPPEDVASLKFRGQLMLLANTPARYENPGLLDEALTHIPLNRIYAEAEEESQMYEAEARSLGKERGKWGYQDCVIMALLRWFKRDFFTWINNPLCPVCYSETSPEGMTQPLPDETARGATRTELFKCTNMKCGTYERFPRYSDVWALLNTRRGRCGEWANCFSMLCRAVGSRVRWVWNSEDHVWTEVYSEHVNRWVHIDSCEEAWDKPRLYAEGWGKKMAYCIAFSHDGVTDVTRRYVRLQKYALPRTKCPEAVLVHILNEIRTMRRERLSPSDIKRLEKEDYLEEIEFRKFEWQALEAEATKNGARRTAAPGEKRPRQSGTTDWKHRRGENGIASEAVSPLDAPDARMMEHDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHE8</accession>
    <name>A0A2T6ZHE8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_997081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHE8"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="189"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="281" mass="30104" checksum="D1EF7F7A5A568701" modified="2018-07-18" version="1">MADFYAGYISGALGILLGSPLDILKVHLQSRSSSLPSTLSSTPLFPTVTSYIRGTTAPLLGHGGLNAILYYTYNRTLSLLSTPQLQQQQSPLARIWAAGAVSGAVSFVLSAPTELVKVRAQIHPSKSSYEVARGVIKREGVRGLYFGGVVTGVRDSVGYGFYFWAYEYTKRLLQCEEVGGGGGGESRQMTGMKILLAGGVAGCMGWLTVYPLDVIKTRVQAQSECEGLLGKRRLGTWACAKNAYAEGGGRVFFNGLSVCMARAFLVRPLESNGMMVVMGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHY6</accession>
    <name>A0A2T6ZHY6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1195728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000251">
        <property type="protein sequence ID" value="PUU75089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHY6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9821" checksum="E67237C9132CAFE3" modified="2018-07-18" version="1">MHLFYATTLATREPRDFSGRMYCFWKRESDCGKVAGIMPGNIIYLKQGNEIPAGVELIEVSADLRRTKPPGGAVGHSDSHLEEKWIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZII1</accession>
    <name>A0A2T6ZII1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1103006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZII1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZII1"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1073" mass="118415" checksum="BF11679128344B46" modified="2018-07-18" version="1">MASGRSRRGNTEDELFLGSPSPAGTPIQPLRIQKRVGSPSDISQGTASPPPQNFFPHPVQRRPTLPSAAGSAFDSPNLPYPDRPAAERMTGQQQQQPHQQFQQGDLPYPDRERNNRSRQDSAVAPSPERASTPQSAASTGTPQPTRHVSVVHADAYPTPPPFRQREGRPQRLPRQNSRPESPPPHPPPGGEGGSPSPDPLLNPFPQYHQQYWPPPSRMTSTSTTAARRGSPPPPETPATATTEQPLVTFPANVAAQRRGGARGRSNTSQSRTPPQTQVSTPPAQPPTEAPVEAPPRPWTPTEAPGSYPHGPPTVWQGTGGQEVPTQTGGGQPSAPQNSVSVNAQAQQALEQDFQRMNMSASPPPSYASLNHAGAGPSNGTTAQGYSNEKHTVVVGAAAPQEPPHNNHTTHPAFHNDPPQGQLQRAPQPSTQLQPQQQPQQQPQQQQPQQQQPQQQQQQQQQPQQQEQQQQHPQPHPQEHSQSPHPSFTQEQPHFTPPSRVGPSPPPPLPEGWMAHLDPNSGQYYYIHIPTSRTQWEPPVPEPPFNPPPVASPSSSASTYSNVPPLASPGFPPPMAAYADPGMSGMSSPAPPLVHNNSFPIQPPVPQLPLAGIALYNVAPANGEYFGPYLRYTNMDIERGIWLGSIMIITANPQPPTVHLHQSIDLSPNPRQLKANPIYTHKTWTFYRYDIDIQMVDIAAKWTYAITSHLGCTRYEFLVAGRTERNWRFIAHSCNDFSLGVKAEERARLGGVGFMWKDVMQKHIEIGGFHAQLAGGDQIYADRLWREIPLLKEWLEIRGKENRKAAPWTAAHEEEVTHAYFHYYSAHFDQPHLREAWAQIPHLCQIDDHDIFDGFGSYPEYMQFSSMFKNIGRVAVHWYLLFQHHTTLDILHASPDDRDLFTVTGTGWHFVKYLGPAIAVVGIDCRSERNPQQVMAGPTYQGIFPRIATLPPSVQHCILMISVPVIYPRLDTAESVVNTVATGKKAVTGTYNLLGKVSVKKAFGKSGLMSGVVSVFGEVDLLDDLRDHWTHESKDLERTYLIRTLQGISHSRSIRMTFMSGGKPFIPPWALPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIL8</accession>
    <name>A0A2T6ZIL8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_995096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIL8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIL8"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12030">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12020">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056778">
        <property type="entry name" value="UPF0261_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002674">
        <property type="entry name" value="PRK02399.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23189">
        <property type="entry name" value="UPF0261_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0261" evidence="2">
        <location>
            <begin position="196"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="442" mass="47820" checksum="7005873371C52BB7" modified="2018-07-18" version="1">MDPPNLARPTILLFGTCDTKLSELLFLKNALSEHSRPPTVLLADVGRTPVAHPEIDIPRSALLPNPPAGFNELPRNVVISSMSSALVPFINSKLSLSSLHGVISIGGSGGTSLASSAMRNSTLPTGFPKMIVSTMAAGDMSSFTGDSDITTMYSVVDIAGMNSILSAILTNAAGAIAGMAEAYYRTSRAPPSTPKKRAVAITMFGITTPAVTHARRVLEGENCEVFVFHCTGAGGRSMEKLIMEGKMDGVLDLTTTELADELVGGVMSAGEERLTAASRMGIPQLISAGALDCVNFGPMDTVPERFRDRDLLVHNDSVTLMRVDDEEMGRLGTRMAERIVGCLEKPWRTAIWLPMAGFSLLSSRRGPWEGKVGFEKFQENLVKGLGGFLENEPRLELRVEGVEINEESFGELAACRLVEMMKEAEEEDRREHNFFHGKERVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIS8</accession>
    <name>A0A2T6ZIS8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1131410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000234">
        <property type="protein sequence ID" value="PUU75397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIS8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="101" mass="10912" checksum="09B3412F5FBCB121" modified="2018-07-18" version="1">MPGQDIGRDDKREGDDEGGDEEGRRGGIRVDTELFMALGGNRDMEGSVKVLELDDDAARRKRRRAYVLILLIVVVVTVVGVVGVVGGIVGRDYKAAERGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ38</accession>
    <name>A0A2T6ZJ38_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pal1 cell morphology protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ38"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ38"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="535" mass="59240" checksum="EEF259F9C638FD21" modified="2018-07-18" version="1">MSLVQPLVTGRRPSPSIELGTNNPFRRRLSQTPSSPSSATNERFSFVSTRPQSRNPFLDVFEDDFYATERPSSAHKANSFDSSSALRPQFSGATAELFENLAITDHSGDTNTNNMYGRSNDRDNMPPPPYRPQQRHKQLSNGHHHSRSSDEKGAQLIPIDSTPRNPPPRQRPPPNGHFAADRPRDMDRELRRRPRRNSDSSVMELHEAEQKDRERRERRHREQRSHDNRSGSGSGQKDKDDRARRERDRKKNGAPLDLIDKLDVTGIYGSGLFHHDGPFDACNPHRNAKNSRRLAPVHAFPADSANNALSGFGPVNAKADHSHVFGNRDPEAFNDFTASGRRPSAPSELGSTKAIGAFDPKKTAGIIHGDETPGLGTSTFLDGTPAPRAAVQKSGSTNDRPKSPSEMNNSDGLQRKKSLAQKIRSISQNRTMDGPIQSHRRPPPPPPNRSPTDGPYSPTTPGGSFPRNNNNPFFSDYDGAYDRKGETISVSERRAPGSPRKPSLGRVQTSDGKPGENGGLMKRVRSLSKPKRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ52</accession>
    <name>A0A2T6ZJ52_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000230">
        <property type="protein sequence ID" value="PUU75454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ52"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ52"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="52813" checksum="928677A94E89F802" modified="2018-07-18" version="1">MTFHPLRHLPRLQKSRSQTAPTNGSAQKPTSSEYFLQIEPASSSIPGWIITRKYPDFEASHEILSRISKISGVVGFSDLPAWRIHGLAECEGMKRFLEKHNAITELGNNCQGGFARLGKAWPNPQALAKVGGGMLDVLAKASQEAAEGGKALFGGVFRDGVGIKRSSTSSTSLSPPSGYGDNSPQSGTSRSSMESLKLAQPTTRERSKSTATINESPEADLMTLEFETQNPTLPPRPSSIVEEAAEAGPELPPRRSSTRQSLMVELPGADEGEVLNLPPPPSDMPDDYDHDSDTGITLSSLRANPTPSQLQPNPSLLSTSSSASNLQAMTLPPTTTASPPSEATTPPPGPSPRKKPTSPLSTAEAQFVVEIIFAIISELYTLSSAWVFRRSLLNVAKSILLHPEANTEDKAVGSYIRKIRESAFMTDEESKAWKESAAKDTEEEEEEGGECKREKARRLVRERGLPEAMREVMARCNDLKTLSYRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJH0</accession>
    <name>A0A2T6ZJH0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1102848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000221">
        <property type="protein sequence ID" value="PUU75635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJH0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJH0"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="753"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="694"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="771"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="825" mass="92288" checksum="4C9C306F597E0963" modified="2018-07-18" version="1">MFNPGRVSPDDGASDPKRRRIARACDMCRKKKIKCDGKLPACTHCMNYKTECVFTLVEKKRNPPKGAKYIEGLENRLGRMESLLKLSGLLPEGDGKTDLGDLERRLQDQVQQSGGAVSVKTPSNIGRSSSESMMETPNSSALQSAVNSPGLHKEEDEVEALSDQMCSLVTNNCGETRFIGSSSGFSIFSPKGIQWVNEKTGDKSFQQMVMEAASSESKWGLWKPDVFGPLFDRRGTNPPPSRELATILVQDFFQNFNTMFPLFHRPTFEHLFEKQYSDDPPTHSGWYGAFNILLAISFRLRITHATEPDEEHSISHVQKSWLYFQNAATVITELLLKNTDLLSIQAILGMALYLQGTANPQPSYFLIAAAVRISNSIGMHRRGNSFGLNRVEVEQRRRVFWIMYLLDKDMALRSGRPPCINDDDISVELPDEDPADGVGNVPLRDGKGKTNLFRLMSSFAVIQSKVYMQLYSAKAAKQSDGELLNTIGDLDKELEEWKETVPADYRPENEISMDDGPLVLHLVMLHFAYYNCLTTIHRMSIHHGYWTSRLSNYAIAGLSARPLNPRVFSSAALCVSAARASIHLIKYINKHDYPCIWLIMYYPVSALVTLFANILQNPQDPRARSDLRLMNAVVEFLQTVQKEDDSENAKQNSSSIQRMLSVCGEFHRISQLVLDKAEKESMTRRKRKNDEPKPQSSSAQYSAKSTKSASSYATTTPSTPPANAASPPTSILNQDMTSQLYGEFGTTFSPSNPMSWLNEINPNPAQGFPISPSPSHNPLPPPISSSSFQQPFVPQDLWQMPMTFEWDWADASANMAWNEQGPSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJL6</accession>
    <name>A0A2T6ZJL6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1053617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000219">
        <property type="protein sequence ID" value="PUU75673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJL6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJL6"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19177">
        <property type="entry name" value="SET_SETD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044429">
        <property type="entry name" value="SETD4_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF137">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="31"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="441" mass="50664" checksum="DC4E251B2CC6F6C1" modified="2018-07-18" version="1">MADRKTAPTPATTGTHALFTIWARKHGIEFPKLIPAYLPPAGLGIISTEEITGPDGAHGQTKTISPTGEEVIAFTPNALLLTRENLERFSPGCRLGPLLRRKKDDGGLSSHAVFAAAIAREMRRIAEGHENMWREWIDVWPRAKEFRGCMPLMWSVEESDLLPPSTKRLLDEQREKFKRDFKMVEQKGFEFTKQEYMWAWIIVNTRTLFYKPAHPTYNELPREDCMALCPFIDYFNHSDDGCKVQLTPTGFTVTPTKPNYPPNTQLFVTYGCHSNDFLLVEYGFNLPLEKNKWDEVSITSNLLPLLSEEHKRVLYREGFLGKYAFDKEAFCFRTQAAVRLMLIEHPELDANWRKLEVWKNFLAGHDDGERERYAVEERLLGFLDGLEGEGRRALFEVGKLQRQSVKGVIEMRWTQILGMVNDVRTKMVGENGEGRGRGYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK10</accession>
    <name>A0A2T6ZK10_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA recombination and repair protein Rad51-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_992972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK10"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK10"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8319" checksum="33C435EC57727667" modified="2018-07-18" version="1">MPIEEDFGDDDIFEILDIDQLQNHGIGASDISKLKASGYWTISSVCAATRRNLSKIKGFSEQKTEKVKEAAGKCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKD3</accession>
    <name>A0A2T6ZKD3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1089254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKD3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKD3"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="203"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="697"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU75959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="858" mass="93815" checksum="252D2D20392A6BA3" modified="2018-07-18" version="1">MTPATTTATRNGHSHKPHDRNPYDSDSGSNNEEDDLSPPPPDVNSCTTVEELHAVLTHLTAQDAHIDNKLHTLLLKQSELEHSLARLDLLRAHLGTQVVAARTLSNTMLSPAATTAQRVSSAVKRLDIEQSRVRATLEVVEQVAELKTCVLGVTGSMGAPQDWETAASFLHRAGKIPQEIVHGEFAEEIVPSAEVPDLPSVTLENAAESLCGLFLREFEHAAEAADGEKVTRFFKLFPLIGRTDVGLEVYGRYVCQGVAARARDALAAKKQAAADGAGGLGDFFYANAITRLFEHIANIVEQHGKLVERHYGEGRMGKVIERLQVEADTQGGIIIDTFTDERSIDRKLTDIKSYAFSFLVQSYMPSTRGPMGGPPRSGSPAPGGAGHRNSEDEGVDVKEVDMLLSEIGVMLGRWSLYCRFLARKCLPPEPQGLAETDTLPPITVPPVITNSALYQKVQDRLIVPFNAMTTFFCRRSVEKAFQLDESPSDLSLLLTSHASSSNPPYITSAVDDVMYIVNNLLRRALHTSQRALVNNAISTVGRVLGSDFVGMIQRKMQVESYPKSSSGIPGAPVPDDKILSFLVLLNNLDVASDYTHRLISTFVNASSDIPRADNNSGIDAGNDNAVPLEELFPFQTDAAIVRDALKGMETAFEGKAGELINDGIMVFFNQVVKPKLRPLLAEAFRDVEYLVSLEGDENTYSHSDPDDEGEQEGISPESRDELVKLRFQAGWDALMTPYKRILTGKVFNKLLNTTASYFSKLLEKRIWGYAGRISELGAIRLERDVAGVVGVVVRGGLYGVRDAFARCSQICLVVNMEEDEVGDLLTEAGGGGEDGDGVDWVLEVEERRRARGMVVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKF4</accession>
    <name>A0A2T6ZKF4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">B9Z19DRAFT_1116143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKF4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKF4"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="405" mass="44553" checksum="63191D176DCE752E" modified="2018-07-18" version="1">MAEQNIISNENTVPTLCKRCSISPSVINLRTEHLCSDCFDKYTRSKCIKRMETYRVRYNPPDTDTSPRRLLLPLSFGVSSITLLHLLNSQFQNQLARTTRTGFVLVVVHIDESAIDPTVPPGEESMRAVQERFPGLGEYLVVKLEGIYEFSSAVKAFEIDTGGGGGEGGDWKEKLKGLLGALPTPTSRMDVLQILRTRLITGLARKHACEAVLWGDTTTRLAERTLAETAKGRGFSIPWQTSDGDSPYGVKFLYPLRDLLKKELAVYVSLDVPTPLRPLCFGAAEEEGKRKYAAVGKGITIDELMTQYFEGIEKQYPSIVANVVRTAGKLVTEGGVVRIRRCKICGLPRDGGGGELVLDAETKLGESSSEVNGNGNRNRGKKEGDSMCYGCARSVHGAKPYEWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLJ3</accession>
    <name>A0A2T6ZLJ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_257884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLJ3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="152" mass="17131" checksum="AE583846ECF7B1DB" modified="2018-07-18" version="1">MATAAGCGNIPFCSSVSLLRGYRFFSLYCVDLYSTLILLSGLLSICFYDSSRASYVASACAALTFSWAHDSSAFFPITAQLSDSFVVYCHSEGRRFQAFHLTGSTTWSCRSDLEYPLTSFKLRTESRQTKLAPFVKQCSEGFRYYSFFLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM43</accession>
    <name>A0A2T6ZM43_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_990338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000186">
        <property type="protein sequence ID" value="PUU76516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM43"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM43"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="18487" checksum="1B85EFACE71FA697" modified="2018-07-18" version="1">MSLLRQYSDVFSLLDETARGVHHTNRRGAFSPSFDVHETEQAYVLEGEFPGLHDKSSLNIEFTDPQTLLVRGKTERTHQESSDGTESAVTKKVAKEGKSDTEDKEKDSKPRYWVSERTVGEFQRSFSFPSYVDVDAVKASLAHGILKIVVPKKQSQIAKRIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM78</accession>
    <name>A0A2T6ZM78_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1028671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000185">
        <property type="protein sequence ID" value="PUU76524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM78"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM78"/>
    <dbReference type="OrthoDB" id="5337208at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="478" mass="51882" checksum="1FFA931CA84F1C4E" modified="2018-07-18" version="1" fragment="single">MPTDSGGIPAIAVSRRASVLISSGYTILMILIFMIGWNLILAIIMAFWPTRGDPNRLSVLVALWNSGESMNAMTLMLNGTPDSYFDSTPKGGVTNLLWGLLFVFIALSMSVGNVVAGILVPVQLSIGNVAPAAKHAIFYPDLPFYARGDDMGAGFAKLDSLKVPSALRALGVIEGSTATVRKRVNIDRPTDSGSVGLNYNYTVTGVDMGLLSDPKLKLIVKGSCRMDDTWFLNSTDQKDTYRLFGGNDTFDVDYQPYVDLPPMVNFRVDLDFGETSNISYAMIVNTAGFFSYSPSDDPWYMTGPTAANTSLSYQVRRGRPVLSCWEAKRWHLNGKEVDFSELNMLPGLKMHKFWADNVFTYEFTIPLVIRVGRAAGPSALKSASYASGPSFILDAGSSAVLDDLERLVLASWVNCRNVLRDTTTYPSGEMVNLARGRGGSEEAGPAGSSVDFVLQSGDVVTLSVRVLIAVPAILLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMV0</accession>
    <name>A0A2T6ZMV0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMV0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMV0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="329" mass="34959" checksum="ED5008265959928F" modified="2018-07-18" version="1">MAPSSPVVGTDAVNVTAVWGKDNVVDKGTATSAVMAMSRSRSSSTPDSPSTNSHPVGTPPSKLSQNSELAVEASNDQRSEKSSGSSIYSQVETNELATQVDKDSVRPSTPNGSLSNSPTPSFISRTMTNASSSSSTLNSRPINRTTPEKITVAAVGSLTTAVRNWYKSRNVSGEIPTDMPMPSAHRLPPAEIPPPPTKKTPPINVPKRKTVPPPLLPARNKPKRQVPTPPVLPRNTGTAGSDELLVVAATDSEPTTPSSAVAEDGDSYIGRGGSEEAPSPRLEEGSSWEPDRERLSKRNADEEETEQWHVAEEAELRTKAPWEPDEALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMZ0</accession>
    <name>A0A2T6ZMZ0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1087515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMZ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMZ0"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="31172" checksum="D65FC75A5A3B7CC1" modified="2018-07-18" version="1">MTTPVNPLLTTLLSIHTHDLRILYLSESITAAFPPDATRSSDVSDSLSTATPTPAALQADLSHYKELFSKLRFSYLEQVTKEKFLRAITEDAPLVVEAGENEELEAKLVIAKGELRRSKREVEGILAELEGLSRRLADDHKTVLDYISEATTLPPQTAEMEVEIANLEKEQNPITSPSSSSLPKLPLSDTLTLLSAGEAELARLQKELAEADLALPKKRARLEALESEIGPMEMDKEGLERFASEAVRMRDSARAEGRVDRESMGRWYKAVFEGLEGVLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN71</accession>
    <name>A0A2T6ZN71_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartic peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1066250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN71"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN71"/>
    <dbReference type="OrthoDB" id="5388204at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015531807" description="Aspartic peptidase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42356" checksum="D331F0FA385F85F5" modified="2018-07-18" version="1">MILKIPVLLCCTLLASMSLARRGGGRSGDSGSSGGSGSSSGSSGGSGSSGSLSQNSNDPVKAQQTDLYLMPATYYNGSITITHKLFNTSNNGASCWNNNLWEKTYTYDGVLAIGPKRSINDTNPLYFSLRGFEPIATGTLGARPELLRLTSTTLGELEEKKREDKFGNIPPSPGAGTEGFKVLWNVSLAQNATTVDSKGTTLIDSWDLSANYIHKPLPRREVLTPKQIFKYSTSFVTLSDICVSGYELIAEKKPKSPYGSSFSSVGIMYPDLGAHIDIRGVGTDKVFFSMENSTFGQQPLGVSTPIISMYTPEQPWEQVAPWQRIGSFDFSGDMLNASAVVSIRFEGVKYGEKSSEMKNVTSVEALAWVGAGNALRNRVGAIVITAGTAAGFLVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNE3</accession>
    <name>A0A2T6ZNE3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1087161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNE3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNE3"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="94"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="235" mass="26272" checksum="1492188F6F814546" modified="2018-07-18" version="1">MTPSDTNPAAQEETPVETPAAATEPTKTEENEAEGKREGDKPSVFGSGGQISESVYSMFGGGSKPKREEKDDEEAEPKEKKDGDEEAPESPDVHFEPVVSLEKVEVKNNEESEEEVFKMRAKLFKFDKDSREWKERGTGDVKLLKHQENGKTRLVMRRDKTHKVCANHYVVPDMKLSPNVGSDRSWVWNTSADVSEGEPEAQTLAIRFANPENANLFKKAFTTAQQENEALIGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNK6</accession>
    <name>A0A2T6ZNK6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_988263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNK6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNK6"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="218"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="331" mass="36654" checksum="D577A0B831706B38" modified="2018-07-18" version="1">MVVPTLLRAFFVLASATILFIQSIPPFRSRFLAYGKVATPTTPNTKDAKPSTTAAPQDSKTPITALLDHLAMYTVPHSFFTHFYILALATLFLLGQQISTHGPLYTLLRDLQAPEWAAAAGSARRAMGGQSIHQVVLTWTCLVLQAGRRLYECLFVQKEKETVTKRGEGSRMSVAHYALGLAFYVCVSVGGWVEGTDAIDAFKFTLMNVYSLVGPPSAKSFIGVMFFIIGSGIQHDCHTYLTSLEKYTLPTHPAFQKLVCPHYFAECLVYLGLTIMSAPRGRGPFNVTMWTALIFVGVNLGVTSMLNREWYVGKFGEKSMEGRWNMIPLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP79</accession>
    <name>A0A2T6ZP79_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_894604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000158">
        <property type="protein sequence ID" value="PUU77234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP79"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP79"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="8947" checksum="05FD878B367DACC3" modified="2018-07-18" version="1" fragment="single">PSFLTVPDHDGNTPLHEAAISGHSSMLKALIKELARHNTDSTIINEKNHFGNTPLHLAFQFDHPEIVDLLLQGGANATIKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPT2</accession>
    <name>A0A2T6ZPT2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000151">
        <property type="protein sequence ID" value="PUU77500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPT2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17997" checksum="5A86A8AB9C01BD18" modified="2018-07-18" version="1">MSVFSLTRSLLLFFPLFLNSSNLFTSILVSPFFPLSISSLSRSVAQKSPFFFSSFFLPFFFFQNLLTPSRSLWAEGMSILRKTISALYYYNWMFISFHITPWCRILLNLTHAMLYRCSSSNLTEYSTRVHENGSELIDSTCNRLVSRHTVKCFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ51</accession>
    <name>A0A2T6ZQ51_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ51"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="102" mass="11316" checksum="D647F644BAED6EAC" modified="2018-07-18" version="1">MPFSRGICHSLVCSALQPEPLEWKPMPFICSMAPIDEAHSKAIPDATVAKPLLIKEVFYGNGRIELLIDEQAHKRNRTSPFKRANLGDFSVLLSPSLLMILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ72</accession>
    <name>A0A2T6ZQ72_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ72"/>
    <dbReference type="OrthoDB" id="5396890at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="184" mass="21036" checksum="489A7C5143C69C2E" modified="2018-07-18" version="1">MPTTQSQYAGYKHRVLQATMTRAYNAAASCRQRINETTTSLLRKLNAGRIRHQLAKENLERGRSAMIDRILNTRDCAEDLLKLNTEQYSEEARILQYEADSLVQGPLRFASDGLDEETLGFQKWEEDALKFLDSLSEEAEGLRGYLVELARQAQLMGVEITWWGNPEDPEARVENLEEGELLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ73</accession>
    <name>A0A2T6ZQ73_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1145280</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ73"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ73"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="139" mass="14487" checksum="2A10B09B166ECE07" modified="2018-07-18" version="1">MKLVRFLMKCQNETVTVELKNGTILHGTILSVDVKMNTSLRTVKMTIRNRDPVSLDTINIRGATIRYFILPDSLPLDTLLIDDAPKPKNKARKESEKVRGGRGGGGGVRGGGGRGGGRGGGRGRGGGRGGGGGGGGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQE1</accession>
    <name>A0A2T6ZQE1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_935325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQE1"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="261" mass="28744" checksum="6BC3B13338D2335A" modified="2018-07-18" version="1" fragment="single">LYMAASYGHAEMVKLMLAHPDVNVNTQNMHRMTPLVVAAFKGHESVVKVLLQDTRIDPNVRDTSNATALLRASLRGRADVVRLLLSLDHLEVNIQDDRGWTALGRAASRGHVETVRALLDDERVDVNVGSIGGESSLFVMVRRRSLLDVVKECLADPRFDVHVRDNDGKTIMHVAVQFEPTGMVDILLADPKVDVNACDNRGQTPFYVAVDNKNAPVVATLLTDNRVQVNAEDLNHVGPLERALVGADREVIRLLLASPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQW7</accession>
    <name>A0A2T6ZQW7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_985154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQW7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQW7"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="25090" checksum="63B00F8430DCA35A" modified="2018-07-18" version="1" fragment="single">PRLFLARHGQTAWTLTGQHTGISDIPLTRSGENHVALTSTALIGPSKCIDPANLTKIYISPRIRARRTAELLILDTKGTEVVIDERVREWGYGRYEGMTPKQILVDRRERGLDIEGFNIWKDGCEDSIDGVGVGKGESPAEMEARIDEVIKEVREIQGAGIAEGRKDVDILIVSHGHFLRALAKRWLGFPLRTPLNMVLDPGGIGTLTYAHGDVNQPALLLGGTPGPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR03</accession>
    <name>A0A2T6ZR03_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1108569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR03"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="146" mass="16543" checksum="70A90104D8FED4C2" modified="2018-07-18" version="1">MRTTEMVSSFFRAIAEWMDPLHAADGRIGASHDLLGWDQMETVTVQCCRFLVCFSFSLFPFYIAPLLPLPPFFPRDFSTIQCHPYNRLKPPYPQTPHPGNNCIGDLDNVLRITDCSAIVPGSLTSIGPDYALAYQSLDNNWLKFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRC4</accession>
    <name>A0A2T6ZRC4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1084853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRC4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRC4"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="77"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="559" mass="61353" checksum="6A964CE60FB38520" modified="2018-07-18" version="1">MGLWIIEPKKRGSDDHVPGTAFIGAGGAVDSATTVTGDLDPSLKYDLTGDVPIVLVPQPSDDPNDPLNWPLWERDLITFILCLVSVMAATLGPILAPSTFLFAAHFGRSPTDIALLTGYHLCGVGVAGLLFVASARVYGKRHLYLLGTVMLIVSSVWGGLASSYESFLWARIFQGVAVCPFETLVNITVGEMYCVHQLGKRMAVANFSLFGGAFLTPVIVGKITGELGWQWPFYLVAIFTGAMLPAVVLWVPETAYNRPVYHDAPLSNQASFECTVASSRRSFLQRMSLFSGRKTLESPLKLFLRPIVLLLHPAVLWGMLTQGVMIGWTVMIGVVLASVFLFPPLSFTEVETGYMYTGAFIGALTGLSITGPLADWSAKYLAKINKGIYEPEFRLFLVIPQAVTGCLGLYMFGVTASNTVKYGWFWPDFFFALELMGMTMGAITSALYLVDAYPSIAIETFTCLLLFKNFFSFGLTWEAFHWLNKVGTKHLFIYVASVQVAVCALSLPMYFFGKITRDVMHRHDILKMVGLGIGKAEKRSEQAGLGAEMDEIECREEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRM4</accession>
    <name>A0A2T6ZRM4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator TACO1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_984080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRM4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRM4"/>
    <dbReference type="OrthoDB" id="2017544at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.200:FF:000002">
        <property type="entry name" value="Probable transcriptional regulatory protein CLM62_37755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048300">
        <property type="entry name" value="TACO1_YebC-like_2nd/3rd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049083">
        <property type="entry name" value="TACO1_YebC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532:SF0">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR OF CYTOCHROME C OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20772">
        <property type="entry name" value="TACO1_YebC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="YebC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TACO1/YebC-like N-terminal" evidence="4">
        <location>
            <begin position="48"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="TACO1/YebC-like second and third" evidence="3">
        <location>
            <begin position="126"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="31217" checksum="19B2AF6C73030F68" modified="2018-07-18" version="1">MQSISRLILRHQLRSLGPIGLTALQSPVYVLTCTAFFSSSSHLQSGHNRWSKIRHDKGKNDANKSAEFSRLSQEICSAVKNGGPSPDNLRLSAALAAAKKVGMSKDKMEAAVKRGQGVSASGAALEQVHIECIGPGSVAMIIECQTDNKLGCLAGIKVILRKNGATVTPTSYLFARKGILRLSTGDNSYDTLLESCLEIDGMEDINEIEPGEKGPKVEVEVTADPAKTVAVAEGLKSRLSGVEILKSSIGWVPKEETLVSVDDEKVLEALIKLINILEEMSDVGEVYTNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRS3</accession>
    <name>A0A2T6ZRS3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1127155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRS3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRS3"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="442" mass="50326" checksum="44C7151345412C59" modified="2018-07-18" version="1">MASVKISKPLPALPADWNSESSFIVHAPLSPAVHRNLSPAGPHFLAHARRKRHSRTFSEDDRIQAQQNVKNVEDEDASEISEAESPLLLSRDPKDWKNQDHYAVLGLSKYRYKATDEQIKKAHRKKVLKHHPDKKAAVGAVDDDSFFKCIQKAMEVLSDPVKRRQFDSVDEGANRDPPSKKSKGNFYKGWGLVFESEGRFSRKQPVPKLGDDKSTKADVEEFYNFWYNFDSWRTFEYLDEEVPDDNENRDQKRYIQRKNNASRAKRKTEDTARLRKLVDDALSLDTRIKKFREEEKKLRNAKKDAREAEEKRLAEEARIKAEEEKKRKEEEEAREKAQKADSKKAKEAAKNAVKKNRRVLKGSVKDVNYFVSGNATPALIDSVLGEVDLVIAKIDNEDLQTLAKSLSAAKGADAVKSTWVEAVGELVKKGSAKAEDFKVFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRZ7</accession>
    <name>A0A2T6ZRZ7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B9Z19DRAFT_1193473</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZRZ7"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000031">
        <property type="entry name" value="Phosphatidyl inositol 3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="24">
        <location>
            <begin position="1478"/>
            <end position="2052"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="23">
        <location>
            <begin position="2173"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="25">
        <location>
            <begin position="2478"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PUU78204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2510" mass="282363" checksum="6117A3DF9445FFF0" modified="2018-07-18" version="1">MSARRKRIAAVGTMAPPPVPMADYTAIAGSSQQPLPPSSIAVIFQNLPKTGNGSPGPNFLQQLFAEVISHDVTDPTGSSSIEDTLLVNYKVITAVVDAGVSVLLREDPFASQNLTEQASNSLLVLRLTIKETPHVLFRPPPESTTEPGQPLLYLWLLSKLLPLLGHRLAESLVQELLETIYAVFYAAANLPKEWKSVTVMVGYFRSCVNCILESFQKASGITATLSKSYKLELPEKGFTVDSLMLPEGIKHFSRQTVSFAIRDADHAAFLAVHLFSAISALPAQNSDIPAFRSASDSLIYFAQEMQNLWMSLNTWESLPALYERVGTIRLKILEALANSLEDVVKTRYGRSRVKGVCLLAIRCVGDVLTKSISQINQSAENTLAKIILGLLCAAEVSTTIYKALWERIYPPIILVMSDREGDGWGLLTDDLRVAMLRLVISFADDLVILERANKCLQLATGGRWVFKDERLQEFSEHLHSIKDTRPEEELDNNIGPRKRPRLSEGEPSTEACALTLDVCKLLGHQDADDLRGLSLVAVEGFKRLEEGERCTALKSLGFLSCALAGTLTQAPESFGVQKGLNLYKCSYCDVDALQAMASERSYAQGGEELFKTLEVIQKLEDFQASAPVRVWAMISLRRLLNHTQDLARLDLAETAMGKWCLNALQSSRRLLRVAAGRTLPSYVNFKHGEELLRTNRIMVIDFLRALSDNDEGQLQETCVLAWSQFGRVSSNEELNLALIRLVEYLGHSSSFILGLAYNEIQSLARTHGVTPGKMFSPFWPSISVGVVKQLQSKPQIAQMLAEITGMELSDFLKTTQGYTIPYLILWKRPELVERVAQACKTDVVSLALSNMAHILALLLTQEADNVEAFALHLLAHSTVGFKDISLGEIARPDAMSLATELLKAAVDADEERKARIFYALRLVAALTYKKAVGTRRNKEIDQLEAFFEMNVLGIFATFNDYLKDIKGKLSTPEKIRIMRAIEEMMKMARGSVSSAVPQICACLQEALEFEPLRASAFSVWTVLMRVLEPAETAPLLGQTFSVVLQYWDSLEQASQTKAAEMIKELFEKKIDAIKESLDILPSLAAIPTLAPFEERLKAMRTLEIRDHYHLLARRCRHENVSVVEQALAELFVFLKKHQDFIHTAAINEQPDVVVPELIRTLLDVIIAFKDSNSSSKPRIEHLCAACLGLIGAVDPNRVEAPRDKRDMMVLHNFTRADESIAFVIFFLEERLVKAFLSATDTKAQGFLAFGMQELLKFIDVESTVILRSRHDGPAHVAQTGQQRWDSFSQTAKSILAPFLRSKYTLQINNSVQPCSYPIFSLKITYRAWLTKWLLDLLSRSTGDNAENIFTVCKSIVKGQDTSISIFLLPYVTLNVIIGGTDLDRENIVKELHAVLAPVPKNPLEKPMARETLRQCSDTVFQLVDHLTRWLRDKKQFNLNMKNQQVRQQNRSFASEEIYDQDIAIARVEDVISAIPSDTMSLRSVECNSYARALFYWEQHIRKVRVAKEEVPMDPLYEQLQRIYTQIDEPDGIEGISTKLHVLDFDQQILEHRKAGRWTAAQSWYEILLSEKPDDPEVQVNLLDCLRESGQHEMLLSQAEGMMEKYPNTRPRILRYAVEAAWISGKWDVLERNLEKSNEHTENLYELRVGNALRALRKRDSGTFEKAISLARECVLSGLTESFTGSLRQCHESMVKLHALSELEEIGTALASKDLGKDVLAPNLLRRLDVLGTYSKDKQHLLALRRAAFVLSGAPELVKDSIASTWLIGARLARKSGQVAQSFNSVLHASRLGHPLATVEHAKLLWLGGQHRKAISSLEGAIDSNLLQGSSQEQIHDSSLYNSGVHPQPQNYAMAKAGLLLARWLDGAGQTQSTEVVSKYCAAKDHHARWEQGQYYLGRHYNKLYEAEKALPPIKQTQPFLSGEYAKLVCQSYLRSLMFGTKYIFHTMPKLLTLWLTLGEIVDQTIDSKYGNEEFRSHIQRERGKSLKLLHVSIKRYSERLPPWIFLTALPQMLSRIAHPQESVYELLQSIIVKVVAGNPQQALWSLTAVCRSTARERAQRGSLIMTQLKDTFNKGQKDTLNKGQKEDGLNVRSLILQATKLTDQLLHISNVELLGLKAPTTISIKEHGFNHKCAPCALVVPTQIMLTVTLPSVPDTIKMHLPFPSHQPTIFKIEEEADVMNSLQKPRKIKIRGTDGKLYGFLCKPKDDLRKDARLMEFNNMINRFLKKDPDSSRRRMYIRTYSVTPLNEECGLIEWVNGVRTLREILLTYYKSKKMVVDYPKIRQRLETNCPLPERITIFTDEILPKFPPVFHEWFAELFSEPSAWLASRLAYSRTSAVMSMVGYVLGLGDRHGENILFDESSGDTLHVDFNCLFDKGLSFEKPEKVPFRLTQNMVDALGVTGYEGVFRRTCENAMRVLRINEDTLLTLLETFIHDPAVDMVKKARRKPANAKIPETPKAVLESIQSKLKGLYRDETMPLSVEGQVEQLLKEAVDPANLCAMYIGWCAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS26</accession>
    <name>A0A2T6ZS26_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS26"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="221" mass="23990" checksum="DA759899DB50B449" modified="2018-07-18" version="1">MAADSAIRGTRCGIVRIRDWIHSREAIVVRLDKLIAEIVSIKGQASAVESRDLKTKLSKCPGSLSLSGAAPKRSGEEEYEGETTSMVASLVSEHSESGAQALAPAPVRPGGVELGGFRRLGLGRETSDEPKILLRESEAIAMDSSCSSASGVSESSLREHARIESNLWKLFGIRPEPLHELLFRNGPFRISKLGYAMLQSRFLRAEITTRPSLAQASYNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS64</accession>
    <name>A0A2T6ZS64_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1142917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000122">
        <property type="protein sequence ID" value="PUU78328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS64"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS64"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44487" checksum="0F6F955C18AD38FF" modified="2018-07-18" version="1">MAVPSLLNYSAEPDITGPEAMEFSVIHRQPTSVPKIAKIEYVNKHMVLLKLDHLYDAVAGSLGVEQKKRLTVGVELGTRPDRFLFLDEPTSGLDSQSAFSIVRILKRLSQAGQAIICAIHQPSSILIQQFDMIFALNPGGNTFYFGPVGENAARVVLSVPLDKLEATWSRRSEEHIDRLLNVFQESKDKLFKRSQEGRARIRNHFQGQLKSFSQEDSVLLKDFDAHQKRQGVKAEELILQNRALWNATLEAKTERMKLERKLNVLGALERIVYQAKLQKKVPPTAGIQQGLGTSYGANFLETATGYLTNRSAASECAYGPCSVADECLHTMETPIGCKWKYFGAFGAMTITNWMLLYVFVYTVRIRGWTFGMVPLFRWIGFGINFPMWVAEKSMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT70</accession>
    <name>A0A2T6ZT70_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT70"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="137" mass="15337" checksum="1C88D218CC8522F1" modified="2018-07-18" version="1">MFRWCIGTVWCPADCSRFNRVPPNIQFLFLLVIIIFLSNSHISALSPTTPPTPSPLARQYDPHLAACPFALAFIQHSMTHALPIGGGMSMSYGRHVGEYYISLTTCANHDQRVIDMEARFPCHNFTKSPLQPFSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTM6</accession>
    <name>A0A2T6ZTM6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTM6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="22913" checksum="ACECB5796AC7C8EE" modified="2018-07-18" version="1">MWDYVGERVYSGILLSVITRMGFCALNFDSQSDVTLLSQIPVCKSMLCPWPSGMIMEVHISQTPLKRHHAPYHRESHHTKPVLHPVTLLPSTTPHFPKHPISFSVPFRPIHTHSRPNQLERNNRNHKPRRGISSQTNARVESYSKQKEKQRKRKHSCKAKSVDSLHTAAATTTTTTTQTARERLMREQNRKQKEIPQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTP9</accession>
    <name>A0A2T6ZTP9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear distribution protein RO10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1083131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTP9"/>
    <dbReference type="OrthoDB" id="5403729at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23888" checksum="5D89F02B4A84A4B9" modified="2018-07-18" version="1">MAKTLDKVAEETVHSLETRLRRIEFVLSGTSEDPISDLFALRTAGRENSVHARLAALEHDLAKLCRKSTTVKEMIDLYKNYPEIFKNAQTHPYATSSPSTLTPSERLSTVLTAASSIHATSSQLTSIRDTPIPDPNASTDLIALIPRINRAEVVQQTQAREIAELRRRSAALLERWYLLGIEGVNECFAEWDERTLEVDKLLSRRLKMAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU28</accession>
    <name>A0A2T6ZU28_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1082816</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU28"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU28"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000697">
        <property type="entry name" value="WD repeat protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="773"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="848" mass="92581" checksum="E690A53E06CF59F5" modified="2018-07-18" version="1">MGLDNTAAIDPLTMQILRRTGTENTLRQKLRKDSYDDSIARNPGESVGGIGEGNTPDAATRNTDAQPQSREKKKGVSFLSRIMGGKKKDGDMSNDEDTSEGDIRTEGMDAHVFSQPIGYIPQFPAPPKYIKVRSRNKPKRDFDQTFLAQELYRKPAYEEDGKLAAGSTANLSPLPPALPKHKSGAIWAMKFSKDGRYLAAGGQDKIVRVWQVISTKEEREAHENALNIIYYINTEDAVGAGPGGIYSDGSGVRLNAPVFLPEPIHEYTGHTADVLDLSWSKNNFLLSSSMDKTVRLWHVSRKECLCAFQHSDFVTAIVFHPRDDRFFLAGSLDSKLRLWSIPDKSVAFWNELPDLITAVAFTPDGRMAIAGCLSGLCLFYETEGLRYNTQVHVRSSHGRNAKGSKITGIETITFPPDDPNGEVKLLITSNDSRVRMYNARDKTLELKFKGYENTCSQIHATFSDDAKYVISGSEDRRVYIWNVGLGETEKKDKKPVEYFEAHPAIVTVGVMAPTKTRQLLGSSGDPLYDLCNPPPITLVSRSDSVSSKKEAELSAVGRLSEDDHVTSHMPKVLEESPAYVARSTHSDGNIIVTADYTGRIKVFRQDCAHVKRRNESWETSSTFSKKIGSGVFGGRRRNSLSHGSDRILSWRQSIASSGSLDGSIGGGRFGDGGSSRNRSISPRKSMGTLSIGSNGTTGRFARSGSVRSRATSIANDTVHQRNSEGGTANMRSPGKSALGEGERPGSSATMPVTGNDRMMQEAHANLAYHNPKHVPTSGASTAATAATARLRRGSRMTAGSDDSADEVFSSDGEGDESESEAVRCKRCGGTSFKAKQSRRGEHKLLCIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU33</accession>
    <name>A0A2T6ZU33_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1064572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU33"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU33"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="133" mass="15013" checksum="8A906C0851A2AB1C" modified="2018-07-18" version="1">MDLGTLRWVQAPATTTLHTQASTRSYSAPKVKGLESDSETPIYTNSVDIWSLGCGIYELFVGERLFVSEHQYFRYFSKKYLFPEEKLKWLSPLNDYGGISLLEPMLSVQPRDCLAAADALNDVWLAALLSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUA4</accession>
    <name>A0A2T6ZUA4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1082628</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUA4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUA4"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="458"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="927"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="884"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU79070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1018" mass="113025" checksum="F1CBDE791CDAE269" modified="2018-07-18" version="1">MALGSWKSFNFFIVTPVKAIDESDNVPPLFEGADITALTSGSDTLFIGTSVGIVHVVNSAFKIVRSFPTYENDSEHVGSIRHIKQVEGTKLLVTVSEDLSTEPVLKVWALDKTERKTGLPRCQSTVTIQNGRRQFPISAFATTPSLSLVAVGFANGSIVLIRGDLIHDRGSKQRIIFESEEPITNLCFSPPPTTPNAHAHHGGFGPYRHTPAPDGGDTLYVSTIGRILTLITAGKGTGQPRVLEPQGCGPGCMKPAVDFSSEEKGLAGEGSDIVVARDDAIYFYGPNGRGACYAYEGPKEMVHIFKNYVALVSPPASQPSTAPKSGGMTGTLKRLVGRGVATTVTEDPFDVTKFTLLDTELKFVAHSERLISGVKQVFSTWGDLFVLTFDGKVHRYHEVSLQEKLGILYARNLYIPAINLAQKAGVGEAKLRAIYRRYADYLYGKGDWDGSMQWYIKAIGKSNEEGVSTVIRKFLDTQRIHNLIEYLEELHMHDIATSDHTTLLLNCYAKLKDIEKLEKFIKVSSGEGLKFDVDTAIAMCRQAGYYEQAVYLAERQGEHEAVVGILVENLGKVDEALGYTKRLEPEIAYSSLMRYARTFLQEVPQQTTDFFIEYYTGRYIARKKEEPGAQMQHQEGRIQSYLNASLLQQLPYMGGGGQLEISDSAGGEGGTVPLDLPAPYKPPKPRTAFSSFVDHAKEFVEFLENVLETAREGVLSEGDRVDIYTTLFEMYLQRANEAKTKEEKQQWETKAKGIIEDKETSIDTSNVLLLSHLSNFRDGTVLVREQQGLRFDIFRSCCSAGDTAGAVRALKKYGAEEPQLYVAALSYFTSSPKVLADVGEAELQRVLKVIDEQGLMKPLQVVQTLSTNAVATVGMVKRYLGDTIEKERREIENNRRMIETYKTETEKKKAEIEDLGSKPSVFQSQRCLACSLQLELPTVHFLCKHSFHQRCLNNVDDNPECPTCSASNQTIRTLRKAQDEYADRHEYFNSQLQESRDKLGTVSEFFGKGVMAAPPVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUS7</accession>
    <name>A0A2T6ZUS7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1064415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUS7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUS7"/>
    <dbReference type="OrthoDB" id="2432464at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="20767" checksum="01983E60D10B7FCC" modified="2018-07-18" version="1">MAKDATDNRIFITIFVTSKGITPIQMLEHSVISCLSNMLEVKDLSYSEVTNLLCNKHNMSVSQMKAIYALIGRWIKLIKKVTRELEKGTNWTRVEKLILAQAYKDFDKASMISGGKFRDVGRKISKHILKCGYISHDDLRHIIPSIDSREMFLSLNVFASMPELDSITFHSKPTEIVAQKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUZ4</accession>
    <name>A0A2T6ZUZ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1082262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUZ4"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="248"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="901" mass="97420" checksum="EEAF7A6F56C4B6D6" modified="2018-07-18" version="1">MDDLAGLAWNPSSSSSRPPPPLKPTSPAPLNARPSPLSSRTVSPANASTKPPPTGDSFSNLVSFGRSKANDNNMTLQERQKQLQERRAKEEEERRKQMDALFGDSQAGANAGFWDSLETGRASPMPAKKIDDDEDDLLAAFNAATPVDNSSYYPPPIGSGVATPLPLDPTPVVMVDSTNSGKGSSNNIMDPFDLDNLPSRDPSPFKPQHGSSGAFGDDDILGDLGKPVEALPPKVSPRVEEPPLPLPGNDPRDPAIAEIVDMGFTVAQAKRALAETDTGLDVTAAVGWLLEDAHRKSRPASTNPSGSRSGSQARQERSADPPRRRREDGGQPAWMRDGNGETQEKDIGQMASQIGGTLFKSANSLWNTGKKRVGKAIAELQDGSTNDGGDPNIPKWMRDAQQHQSEAAGSSEKQDRTRFAEEDMRPARPTQREKAPEPLLTEEALMLEAGSGPPPRRRQEKEKPSRALSEKEQIQLQRQQAFEAAIRQKEQEMRERERPRQTPSPAASIPNSSDRIAKLTRGAVEDSAVQYVSKNRRRPPPPSSSSARSSPKPATPEPPTGDLLFGGSSAPREPSRNPFLQQQQQRQTPSPAPQRPAPNATAPIVTRPTANRQEVPISQQALQASSVSRQKGTDSFKRGDYPTALTHYTSALNPIPPQHPIRIIILSNRALCNLKIGDSRAALADCDEALGIIGPSNGESETIMLEDGTKKDMKELFGKTLTRKAEGYEHMEKWAEALKTWTQAVEASAGGAIAISGKRRCEAALQPKPAPKPKPAAAAPPTARRAPPRSSQSTSSSTGEAARVIALRQANTAADRVEEEKLALHDRVEDRVNAWKYGKEGNLRALLASLDTVLWEGNGWKKVGMGELLMPNKCKIAYMKGIGKVHPDKVVFIPLSSLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVD0</accession>
    <name>A0A2T6ZVD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1107669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVD0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15234" checksum="70B4340DCB9534E6" modified="2018-07-18" version="1">MFGILARAARLPIVARRLSLAKGPIKQRYRYSSTNGAGGPNQAPLNLPVDTARMWEWLGHVEAGVHAEMVSMMEGIKLLGWRSTAALVAFIGSLGYAAYTIDQVKRDLPNTIVDVLLDKHIIAIPSLPPPQPAPATPTKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVF7</accession>
    <name>A0A2T6ZVF7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1081751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVF7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVF7"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="260" mass="29517" checksum="B22E79F42DE01563" modified="2018-07-18" version="1">MARGPKKHLKRLNAPSHWLLDKLSGKYAPRPSPGPHKLRDCMPLVIFIRNRLKYALNSREVKAIVMQRLVKVDGKVRTDPTYPAGFMDVITIEKTGERFRLIYDTKGRFTIHRITEIEASYKLAKVKRVQLGAKGIPYLVTHDARTIRYPDPAIRVNDTVKIDIETGKISEFIRFDTGTIAMVTGGRNMGRVGVITHRERHDGGFDIVHIKDAIDNTFATRLSNVFIIGQDKPWISLPKGKGVKLTIAEERDRRRANALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVV5</accession>
    <name>A0A2T6ZVV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1081414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVV5"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="148" mass="17825" checksum="00377521FB50FD76" modified="2018-07-18" version="1">MFYLLASSYNLYTFLRSFTSTHYPRGQLMLREMSWMELQSFIVSLTIGTQRYKEERMRRVFAWLPKRKWVFIGDSTQTDPEAYATLYKEFPERVGRIWIRVVKGVDEEKEKELNLEERFEKAFKGVPAHVWRTVEQPGELEESVRELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW37</accession>
    <name>A0A2T6ZW37_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1046287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW37"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW37"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="96391" checksum="FEE902A083856FFB" modified="2018-07-18" version="1">MPSFRDDHILVISPGSQVTLAQLGLPESFTPAKLRLASRMFPALEPGTWTWTKVREAREGEKDRLLATVMARQDDDDEEEDDEEEDDEEEEDEEEAEEGDEATAVGTKPEDDSTEKSKTSVPSVAGAINAATEDTAKFDISEKREAKAGEEMATTMKDEAKPSASELKAEDSEMMDVAGEQEEEAEEEEEEEDDDDDEEDDEEDEDMGDVYVEDEDDEEGAVWCMKEGKVVDWGCFFALLQHVHETINPTFHTPILMLCPPAFTPSDKERITQFVFEKLKAPGFVLMDMALATLWAYGLQNSTIIDVGFEKTDITPILDFTIQERARETVPGWGGESMTKHLMKLLPDLKYEEVEQLKRSPICEILHSGHSLPNASSVNTAIAAGNDKMKRAAEMDGSDLIDEEEGTMNVAAIVASGKTHEFLAKREKEKRGEAERKLPNRERETNSFWVVEKKKPGDEPTSSSAMILDEPQSAVSVSAPKLPEVVVGAEAPPAIPVATVASEVSSTTTAPIPEIASIDATPAAPAAPTNPTESAPPVPPVVTTEEIAATFAVAPVPPVTTEAVAIESTIVEKPKPEDPTSEPAKLAGAPETAVVTEVVATTEPPTTNTAETTTVTTTVTTTLQTAGTAAAVAQETEAAPLPAPAPAPAPAPIAMDEEALRKQKEKERRKEEKRAAAEGLPKIGEDEIRREIQVGVERFMAAECGILQELTDRIWRVISKVEDVSRRAELWESLILVGNGSKIRGFKEALLQTIQSKYIIPPSSATIFSSELPSNMSTPAATGTSTPVPQAGPSSHTGANPLLVAATTSNLSLPAMGHHGHHSSHGQTPTNIKFPRPPEYFPEWKDAGFEEAAFLGAQVAAKVLFIVDQGASCGFMTRVEYNEGGPAAIHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWM6</accession>
    <name>A0A2T6ZWM6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1080622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWM6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="58" mass="6427" checksum="AD8433981428CD57" modified="2018-07-18" version="1">MTGIRARRIRRVHCGGGNKQGNPMEYTATDFSRIMQVNVTGAFSTARMAREMVEHGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWV7</accession>
    <name>A0A2T6ZWV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_777791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWV7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="9984" checksum="9DBD79D453D9C54D" modified="2018-07-18" version="1">MISGYLLRYREPGRKFRRNALTCQRERLHPLISAFHSILASYTPFLSFPFPVFLLLSHQTSATGQSTLPHHPPLLLVVTVLISFSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWX3</accession>
    <name>A0A2T6ZWX3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_775380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWX3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015755857" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8835" checksum="AB2A73983B4D067F" modified="2018-07-18" version="1">MLCLFFLLTFMSVNKVRLRVLYQPSNPITFASITKHLIVIFNPSLPPLKQHGARVPYRTSKVVKPHHHHHHHHPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX31</accession>
    <name>A0A2T6ZX31_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1080346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZX31"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="775"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1029"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1095"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1143"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1340" mass="150766" checksum="E9331CFBD1BE0330" modified="2018-07-18" version="1">MAQDRGRSSLSHEYSVLPSHAPEIISTNTEFIRSHDKIETLVTAERARNFEGLVRRYIKQLLYGCQRAHCDTPTCYTARKRLSRDTNASRKFSVLSARIIACQLATQDDPYKALCPGKLVTPVLSSPVEEKKDGLSRDSSFREEIAEDGEDTSNKENKEAPVRPAKEALKEGEVEEITDKGLKDPKSFPQQLFNTRPFKMLEWIGLPPSVGILKFLSESAVSPAKTPTRSSDFNNERDAATPTSLHEQPPRFKDYSNPMELIDLGRLNKDSEPVSHHKHQEILQQPPVPPRKRRSSNASKVALKDVTPTPHSNTRSKITTPGSRNPNMPPPPMGPHPHQKSKTVNSQPQLTPSRSEKHSLTAQSLMTEDEDLTPQSLTKLDKEICAALLKMCTDPAATSAQCREAALFAKQSLFYVFSTPEALLRSFVSEKAEPGSDEIDLDLDDVDQAFRILFGNEAWEAQVMQGLWKGLEVVFKIPDEEGRLSDKDTAHVISIALHALAAAVPRSTPEEWMAVRKLRGSGRVSEAGAISEIWFEDEMAERLMRRVVKAVAYRHSREDQVELRLQRHLRNCGAFQFEQRRERLAREVGEDLAKAYDRERGGWGLGVCTLEWCRAILLKAWDGQETAHMAGVVGCCLVLMKILYDGHQSYGIDQEFFHTRALSDRFDPKDVSVQWFDSEPKAGVLHLLDYAFLFPENLRVTYFRAVNLAHMTKAYEQSVTVQRLASRVSMNTAFLNPHDERLDQRLRIPLSSYLLVEIRRETVLHDALNQVFEREIRELKRPLKVRFANEGEEGVDHGGVQQDFFIVAFREALRPDYGLFTTDEQTRMNWFSVAPIEPIHKYELLGLLVGLAVYNGVTLPVTFPRILYKKLLGGEAEGLEDIEDGWGQLAKGFKQLLEWKDGDVGDIFLRTYDFSYDFFGQVKHANMVKARENRVEFLDIGLNKVRIANPRFGQTGLEGARGWLPGPSLPVPSLPVPSLPGPLLPGPLPDHLSGRRDQWLGRTNDELSGIHRIDGSSYHFTIMEWPGGNVRGIGEEEGEASGVDPGRDRGGEGSSDEPLEPAISETTETGETRVASEDGESQGTEPLKVDRQNDGTEDDVFQDAGEEVETSSMKEGSDDMIEDSREQPQVQEKGKEVAHVSFSPELLEEAPAAEGSPSSDEQEPEEEAPLVTNENREAFVKDYISWLTDRSIRRQYQAFEKGFFVVIDRKSLSLFTPSNLQSLTEGIQEIDIAELEKTARYEDGYSPTHRVIKDFWVIVRGFSAERRRQLLEFVTASGRVPVNGISSIMFVIQRNGPDSDRVPTSLTCFGRLLLPEYSHRRKLREKLKLALENGKGFGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX43</accession>
    <name>A0A2T6ZX43_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_898184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX43"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX43"/>
    <dbReference type="OrthoDB" id="4207594at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000298">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="311" mass="33148" checksum="5B9CA6D2D24E8E72" modified="2018-07-18" version="1" fragment="single">MTDKLPANLLALFAPRPPLRYLPHCDYAPDKRRTAPITGVAAYLEALRTPDPDYVPTESWMQRRDRLREEKKAAIAEKTKAALVQYNPESDPQVRGDPFKTLFLSRLNYNVKESDLEREFGRFGPIERIRIVRDKESGKHRGYAFIVYEREKDMKAAYKETDGIRIKDRRVLVDVERGRTVKGWKPRRLGGGLGGRGYTKIPVTRPTGPSFFGQDGPRGPGGFGGRGGGFRGGYQGGGFRGGRGGGGGGGGGYGGGGGGGGSGGGYGGGGGGGYGDGGHRGSGGGGGYSGHGRDDRHDDGGYSRKRAYDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXQ4</accession>
    <name>A0A2T6ZXQ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_975986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXQ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXQ4"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="100"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="29195" checksum="94F25CDC148DBE25" modified="2018-07-18" version="1">MSTTTTTTLTLPSYASDEVRELGIEDCKAAADTLAEAFYKDDVAFYFLDTPDNGGKTREELYPLHNEILEYIVAAHCYNGLVLSIGENHEGVALWMPPGQNMDDWFTIFRSGMWRLWYKLTKEGKRRYFDEFMEILHRTKESVMGAQDSDTWYLVYVGVVPSARGRGYARKLIEYVTKKLDAEGGKPCYLESSHPRNVAMYQKLGFVKQRHIVLGPNCSNPAPLDIMVRPPMDRRRENNSSSRKMSVATGPGRVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXR2</accession>
    <name>A0A2T6ZXR2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1079874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXR2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="53" mass="6000" checksum="3E25EF25A1646CB6" modified="2018-07-18" version="1">MGLGELSRVFLRLAVFSLCLTVMIMMENGGFGGFFFLCLRMVGLCGFFLFFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY55</accession>
    <name>A0A2T6ZY55_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1123592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY55"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY55"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="460" mass="50874" checksum="01A6C9887C6367CD" modified="2018-07-18" version="1">MRLTLIPIDPGLAALTRLPLPLIRAPYISSIETDPGLVEVRWGTSQTPAVPPTEELALASSQKSTPGSTPYFSGPSRDSKDGQLRASLGARRSTAERPSLKPYTTLSAGRGFRMKTNIPDSSDLPRPELKKLEYRKITPFQFSDAAWLTHLGRTGPQRLNYPPNSSGSNVDSAMIGIGYQETSRFERPPTLVRDLPDTLIDHQLQSIEVVGKVAYDMDDQNNKCVTTDKSHERMREKEWVTLERSIPKTVAKPDGSCYGTRRRSSGNYHEKDGGEDSKSFTCDDGECENSNAIVFCDWCYLAVHQECYGVPHIPEGQPLFRKCLAMPNKTAHAPNPLRLKSTNHKNYRTSYSTPDTDGAFKQATNTKWAHFLCVIWIPEVILGNTSYMEPVDGMNSEPKSRWKLVKENHKAKTPSEQFLASITHHVYSTGGGVGAVSLPLSLGIVAANISLEDNIGARSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYA1</accession>
    <name>A0A2T6ZYA1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_974854</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYA1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYA1"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU80478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="527" mass="60878" checksum="5D4BDC7558AC8B0E" modified="2018-07-18" version="1">MESQTKISSFLASSSASINNDPLESILRARSSNGTAQSPKEQSNGEAHLKPVLAHLESETSSVLSSGRTTPIPEDAPPSAHSIQHARRERRRRMFPTVDYESRVSHFDPQSQHRDFRGFFTLFWIGLLIMVLTTALRNLKDTRRVLRTSIFSMFTKAPLELAIADLFMFLSTIACLPLQQAFSTDKWSWGGSGYMFQHALQAVWLVAWVYLPFHLEWQWTHQVFFTLHSLTMLMKMHSYSFYCGHLSECHKRLRALDENNTKVEPTEDADLREALAFEVTSPSGRVTYPKNLTLYNFVDYLFCPTLCYELSYPRTDRVHWGKVAEKAAAVFGCIFLLTVTSEEFILPIMTEAAIRLESVDAYPDIALILLESISLLLFPFMVTFLLVFLVIFEYVLGAFAEITCFADRHFYSDWWNSTDWLEFSREWNIPVHRFLQRHVYGISRRHMSRPIATLITFLISALAHELVMFCITKKLRGYGLVCQMMQLPIIVVQRTEFMKSQKMFNNIMFWSSMIWGLSMISALYVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYA9</accession>
    <name>A0A2T6ZYA9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1079299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000063">
        <property type="protein sequence ID" value="PUU80488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYA9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYA9"/>
    <dbReference type="OrthoDB" id="5420724at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="144" mass="16753" checksum="C66C2FCFF4F237AE" modified="2018-07-18" version="1">MQGSRNSSQGKDLWGWACKDNTRRKLFQDDVNYRLVCRQQDWVLVCAIIEIVVETILIAIYAFAFWRLTSKHRLRKSMDLRDRAHSELWQAKLREQQAEEAAAATNDLETNANTVCNKLTSTTSPQDLEEGRAVTPRLHIRHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYJ7</accession>
    <name>A0A2T6ZYJ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal L28e/Mak16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_974462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYJ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYJ7"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="10"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="12639" checksum="99E0EC354FD22761" modified="2018-07-18" version="1">MSSNVSSDILWAITRNNSSYIVKRGPVKDQIIFTREPLSLTNQHTRKHSGLVNEKGVGVQAGENGNVVIITKRNAEKHGNKPASLYNKTTFSKHKSNRKIYSAIASAVAKKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYR9</accession>
    <name>A0A2T6ZYR9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYR9"/>
    <dbReference type="OrthoDB" id="5468867at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="207" mass="23276" checksum="B3A24231AFE755A0" modified="2018-07-18" version="1">MSANLIPKITNTAQEMALKALSELVDLLCPTHSHELSITHPISSDTLEGYSVMVECGEDDIVWAVQMWANHSFRRIRRSQRISIHSPVPGKAPKIFLRTLKVWEGLVCDDIVKLHRLGELKKDWWEYPVILSQEHKDAIDYYNEGPTNDDPENEIRAIEAGYKASEMSDPTYYPPGHRGSFGSPSAQELDNENEDGQEESLGGKGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYT1</accession>
    <name>A0A2T6ZYT1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1123248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYT1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYT1"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="240"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="320" mass="35982" checksum="B9D7C352AA7966D6" modified="2018-07-18" version="1">MEDVYYKGSIQQGSADAMKADKPLVFFVTGENCWRSMKWESENLRDGEIFPLLKDSSIIFKLKAGSSEASFLSMFCPAETAPYLVVLKNGSLVAKLTPDTPDSTFMTSLKSALSPATSPPPPPSPSTSTSSPSQNSLSSLFADRRVRLEQQQKALAAATREKKAAEVKRRQNNLTPDRKKYVEEQTRRIAQEKAEKERILALVEHDRIEREVRERRKREGRAAVFATPVQAVDQVEEEKVAFNEVLISVRLLHGGLIKAKFLEGKGLGELRTWVDENRTDGAEAYIFMLPPDRKFSALDENKSLKELKLPKLTNLVLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZF1</accession>
    <name>A0A2T6ZZF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1078307</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZF1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZF1"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="664" mass="73156" checksum="FF292C2753B62C0F" modified="2018-07-18" version="1">MMELESLIINPAAQGTSVRKKKFEKTQIASCGSRSSKNNSKLEGDRKGAGFYLPVASFDPLEVNKNSDHADKPYQEEEGDVNDHESYRHRNSDSDSSDEEDDRRPQHRRHLLPSTPATIKSSLSHLFTIIPNSILPSNKMTTIPPEAETMPKDKNPLYFDGDAASVDSDAAKLAEMGYTQDLERNFSKWSLLGVSFALTNSWFGISASLVTGINSGGPIVTVYGIVLIALISACVGISLAELVSSMPNSGGQYYWVSMLAPRSRAKFLSYITGAVGYAGSIFTSASVALAIGSALMGMIQMNHPDLVIKRWMVFVAYQIFNLFAWFFNCYGKTLPKVASFFLYVSLTSFTVITITVLATSSPKQDAKFVFANFVNNTGWESNAIAFIVGLINPNWSFACLDSATHLAEEVPHPERNIPFAIMGTVAIGFVTAFLYSIAMFFSMKNLDELVNTATLVPILELYRQATGSKPAAIFLEFLICFTGLGCQIACHTWQARLCWSFARDRGLPGSQYWSQVHPTMGIPFYAHTMSCIIVALLGLLYIGSTTAFNSMVTACIVLLYISYAIPVTLLLAKGRNNIKHGPFWLGKLGLVANLVLLFWTGFTLVMYSFPYYMPVASGTMNYVSAVYGVVFILTIGYWFARGNRTFRGGSQRTAEAEHIVREHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZX5</accession>
    <name>A0A2T6ZZX5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_972792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZX5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZX5"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="146"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="670" mass="74912" checksum="9A2D5DB89A77E95B" modified="2018-07-18" version="1">MGASKRKQEKTKSATAHKKPKVSGPKIKRKRSKRCVPPPRVAKSESEDEEEEDEEEGEEEEGEEVDNSDDEEDDEEEEFGGIEDEDQGGGMDLDDEKEKSKNPDNGTTKSQTNKLPASKSKESHAEQKRLAAERKLAKPHGEIITRSKRIWEQLRRTKLPPKERKKLIAELGQLIKGRVSDLVFKHDASRIVQSALKYADKTTRANITTELKGSYVALAQSNYGKYLVVKILHYGTPENRKMVVQEFYGHVRKLIKHREAALVIEDIFREYATPEQKSALLQEFYGVEFAIFKDTSDKLSLKELLEKSPEKRTVIMKSLFDQINSVIKKGATIFTILHKAMLEYMLNIRPGTTETTELIELVKEHAADIAFTKDGSQVVIRCMALGTAKDRKVMIKALKPEAISLARNEYGYLVLLSIFETVDDTILIAKTLLPEFQKQLQELACDKYGRTPLLYPFSERHPRVVPRPALAVLEEVDKLRESTSKKDPATRQSELRAHFSQPFLQCIGERAEELIRDSFGCQFITEVLLGSTGDKSSALLALALTAAGDPKAADDGDAPHIVNTAAVGRMYKTLVTGGHYSSKENKVIAITPPLNFHSLLWEQIRPHIDAWATGTGSFVVVALLEAEGFPARQELIEALNRKKLRKAAEEAGNKGANVIVGILEKGGEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZY5</accession>
    <name>A0A2T6ZZY5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1122692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZY5"/>
    <dbReference type="OrthoDB" id="5455315at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="109" mass="12167" checksum="73453159752D0A5B" modified="2018-07-18" version="1">MDFAKAGMHTPVLGQMYWLGVKIYEDKSENMELQWKEMVSGFLDCDNSEYEWILAAVGAGIYICATVHSMKMMGSGSTSCSVIMGLVHCEIMDSDSDSEIEVYSENSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A080</accession>
    <name>A0A2T7A080_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1043471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A080"/>
    <dbReference type="STRING" id="42251.A0A2T7A080"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="148"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="671" mass="76908" checksum="331772461877B79A" modified="2018-07-18" version="1">MAKDKHRKKVSDEPKVPVTTDERFISVHNDPRFALPRRKYAKLKVDKRFERMYKDESFAAKASVDRYGRKIGKDAGKEEIKRYYHISDEEDEDEEEARVYDPARGEGVISTSEESSDEEDEEVGEAEEEAARAQVEVQREIPMGEVSRRFAAVNLDWDNVRAVDLLKTFSSFVTRGGRIVSVTVYPSEFGRERMEREEMEGPPTEIFKPKGKTRIIGGDEDSDLDEEVNEKTIIKEDKGEEFDGSKLRNYQLERLRYFYAVVECNSPEAARHIYEQCDGAEYEATANFFDLRFIPDETSFEDDKPRDRCTEVPANYKPNDFSTDALQHSKVKLTWDEDDQQRKLATKRAFSQRDIEDMDLKDYLASSDSESESGTREAAKDKYRALLSATGFGKKDKLEPAGDMEVTFTSGLSEKAKDRKVIEEDEEETTIAKYARKEKERRQRRKERLKVTREGNGEGDKSENNKAEDGKEEEEEAEDITTDLGFNDPFFADTPASKSTEKKEKKRKDREVKAAEAAESASKRAELELLMADEGGDADGKKLHHFDMKQIVKAEKKKGKKGKRRKAEPEPEGIQDGFEIDVKDPRFAAVYEKHEFAIDPTNPRFVKTKAMSKLLEERRNRTQKRNGDDGEEGEGGGKRHKADKVDKVDKGGKDKDELKRLVQSLKSKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0T1</accession>
    <name>A0A2T7A0T1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cysteine proteinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1077282</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0T1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0T1"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="92"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="214"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU81334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="62416" checksum="F5B6B695AE0EF554" modified="2018-07-18" version="1">MSKRPAEETVEALEAQQQSTGPQTPKRARLEEVIDQEFVEKGSSRNGMILEASRPRAPVLATDMDGDGDEEGNVAVGQLGVGKAQEGPSEGFSDLYLDTINRVLLDFDFEKLCSVSLSNINVYACLVCGKYFQGRGRSSHAYTHSLDQDHHVFINISSLKVYVLPESYEVQNKTLEDIKYVVNPTYTKADVTKLDKEPLIRRDLGGKKYIPGFVGLNNIKQNDYMNVVVHALAHVAPLRNYFMLEDLLSRPELAQRFSILVRKIWNPRAFKSHVSPHELLQEISLRSSKRFTLTTQSDPVDFLSWFINNLHLSLGGSKTKPGTSIIQKVFQGRLKVESQTITARADASDRLRFEEAAEIKTDIVRFMMLTLDLPPKPIFKDEQDKNIIPQVPLTTILSKYDGVHSQELLGQRKRYRLLSPLPPFLIFHIKRFSKNKFVEERNPTIVTFPTRSLDMSPYIEPSEGGSSTEPVWYDLVANITHESVTTTSGKKEGDIRSVYKVQLVNKASGEWFQIQDLFVEEVARELLFTSESYVQIWQLRREAKKKGAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1N0</accession>
    <name>A0A2T7A1N0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1N0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11334" checksum="386F24CDE706B3DE" modified="2018-07-18" version="1">MHLLPEVFMGQIQIHIVGIGPVLASKGLSRWKRLYQRYEQECILVKPRTLSSVYAVQEICESWSRSATPTTLPSSRVKDEASSSKLIQEPHGTYCHQHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A230</accession>
    <name>A0A2T7A230_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A230"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="358" mass="40747" checksum="376C2538B4304EE9" modified="2018-07-18" version="1">MASPLNRNHHLKAMEKTAMGEEEVAPIGHSNSTYVEKCIQKFNDWHGRKNPLGLCEDEQDRLAMSLSISDFLEMKKVLKIDEDEKFPRYCYDVSSTTLTIQRMPSPIHEQVMSTVAGGFSAVQASLPTNYRRSIQIVTNQVFDEFDGRHDGTEKIPDTAVQITDAAGMPRVRFILEVGLSESYEMLVHDAQTWLEGNNDVTLVMLVKLEENPPYVCPVKDLTDEEFEHLKFPDRKSINVKTFALEGDYGPATYMGLAWVGEISGFIEVWERDKLSGMAQITAAGRINLFNLLNTQSTLFTLRDFMELPVEGDHKVLINWDDYFSNLGINICQLAAYRCRQMRKDRAGKDDIRDADYEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A249</accession>
    <name>A0A2T7A249_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1163518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A249"/>
    <dbReference type="STRING" id="42251.A0A2T7A249"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="7734" checksum="8FFB430EFE242DC5" modified="2018-07-18" version="1" fragment="single">MDREQEDKVVYGEDREWAKKAAPSIEAQIETVKGIRSLKGYPLEAGSTRKKEKKPQIKFDENQEDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A316</accession>
    <name>A0A2T7A316_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1190714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A316"/>
    <dbReference type="OrthoDB" id="5409012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015750220" evidence="2">
        <location>
            <begin position="19"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="374" mass="39352" checksum="E1EE515583769C4E" modified="2018-07-18" version="1">MQTLQFLFILPFVQYTAPSPLPNKPIRQILPHSHYRNHPRSADPSSQFDDPPIYGPGPGDFCDPPTTITVTVPSPATVGGAQLEPITSTVTVAAKGVDTGLFDGIFGPINIGQSVKPQRVITVAMETSTVVLPGSTETVTMRVTGSEVTVTGETREVTVTVSAQNAGDVPSTIITYLTSTITERDTMNTREPMPKLSGKKEDETAKSGGEDSAETPIPSIPSHRSFVHLGGMRAQAQSPTAEPQTLNINPEEAPIPLPLLPQPITYHNPSIPTETPTSTPAPTTATPTELDSSATATAERTGIREFSKMSSSAPAEPSINALGNDVEDGSHEDVAALAAQLGSEQVHHPSGFVPDYAPKKTATLAPPAATTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3T9</accession>
    <name>A0A2T7A3T9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RXT2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1112929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3T9"/>
    <dbReference type="STRING" id="42251.A0A2T7A3T9"/>
    <dbReference type="OrthoDB" id="2405722at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039602">
        <property type="entry name" value="Rxt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013904">
        <property type="entry name" value="RXT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28232:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RXT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08595">
        <property type="entry name" value="RXT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcriptional regulatory protein RXT2 N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="490" mass="53267" checksum="029E03B69215DBB4" modified="2018-07-18" version="1">MAADRQYLTETIANVKKVLAAQSDGSESDDSIAYTSNRGRKLKRKARFVHEGALNDAKGPRVYKKEIEFYGKRRKIIYQKEPLRKRNDDSESDAEEDSDDDTTSVSDDLDPYSEIRIDKILAPCENAADLPSHPSMSHIYTSRTLNDLLQQSLTKLCEEQAHTTKLKNLLTVFLGDDPFVNLEKMQWPDEDFAAIARERSDNLLRELGGPLLSARGSISNPTTTALPSVPAPLPSVLAAPAPATSATATSPLKPTTNGDFPTALPKDPIPSATTTITTTTITTITTGSPASSENPPPLTATTTAEDMDLDPPLAAPLKTEPTTPPTPPPRRMTTRSTQNSHPTSPPPISPHRLQEIDPWFFPPTFRVDPDFGLPAPEAAETRHLLSSAVQHQDEFLRGLNKVRDGLLRAERFRKYGVPRCGGGGGGGIEEGGVDAEVEAGATLSDGEDYYDPVVWGLEEPLEKGKEEEEENGGEVVNAGKKTRGRRTVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4B0</accession>
    <name>A0A2T7A4B0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1120479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4B0"/>
    <dbReference type="STRING" id="42251.A0A2T7A4B0"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="31354" checksum="70733E886933E14D" modified="2018-07-18" version="1">MSAIKKVILVGATGNLGPAILKALQASTLETTILTRENSETAKNPPENTKVLTANYASVSSLAAAFAGQDAVVTTIAGAAVGEQQVLIDAAIQAGVKRFIPSEFGSNVTNEKTRGLAVFAGKIAAVDYLKKKEAEITWSALINGGFLDWGLKVGFLGVDIANKKATLYDGGNSPFSVTLLSDIGQAIVSILTHPEETKNRYVFVQSAVVTQNKLLAAAEKATGEKFVVEHQNTEEVEKAGNEKIAKGDFSGFFDLIRRCVWGEGYGSDYSDKLDNEILGVKVLDDAGVEAVVKGIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4D6</accession>
    <name>A0A2T7A4D6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_967010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4D6"/>
    <dbReference type="STRING" id="42251.A0A2T7A4D6"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="275" mass="31178" checksum="D525F7270112CD20" modified="2018-07-18" version="1">MFLSNRLAWRDTTIYASADRDKVLGGLWAAEGITNENLYSMIEIFGFSTGTFTLHNNSGQLVERDGQKLQPGNYYIATNGSIPINDEFPLSCTNLIPAGTPVEPFRQAVRERDRRCVATSRPASRGHRGWWLNFKSTHVVSLDYEQHWNDSNFGRWITVPPADLSHGTINSVQNGILLTREMHVSFNNYCWSINPDDNHKIVCFTPDFDHYQIAGRHLDPEFLADPRRPPDELLRWHFRQAVLANMKGLGQPCFESESPPGSDIMGITDEVVLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4T1</accession>
    <name>A0A2T7A4T1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_921851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4T1"/>
    <dbReference type="STRING" id="42251.A0A2T7A4T1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="13766" checksum="78B23ED94A1159EB" modified="2018-07-18" version="1" fragment="single">TVLHLAAVGGHVDVVQLLLSRPELIRNVRDLLGWSALHRACRNGQSEVVQCLLEDGGFTVTAPDRHGDSPLHLAADHGNEEVYDMVELLLDHGANPNVEDHRGDSPFVRAVNGGHERIVKLFLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A536</accession>
    <name>A0A2T7A536_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1098978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A536"/>
    <dbReference type="STRING" id="42251.A0A2T7A536"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="446"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="329"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="471"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU82852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="566" mass="58801" checksum="8F8260ECA93744EB" modified="2018-07-18" version="1">MSPAVVSRQQSGSAGHSAGGTSNPSSRMGTHSPVDSKKSNSRSEDKQRSSSDQSNNNGRDTAKNSSKVASHTLSPLSNSSLPVASSIHPPQVAVDQPPDATKPSQQSNHGPGPSRPLPNKKLPGDTPGGGGDYFTLSHTRLDQEPNPFEQSFASTSDPLNTPKTILPPVTAITSPASLLPGGSGGSAFNWGANSLRSGPLSPAMLQGPASNSNVGSSAFEHIRSGLTPNESGIRSGLTPGGSGSLFAPSSVGNTIFQQFVGGGATPGTMEFQRTALSAARKSSHPAPSLMSPQQQHIKQQLDNYHVADPAHNAANGLYLLANAQHQQQETVGASGAGMNAGSAPNYPGGPTSSGATAIDSSRSSDEEMQNAGSRRNTRPKNSKGKQSTASAGRRKADDSPGGTGRSQAKKAKGPQGQSMSVSGGSDDGQDDEKDENGKDTKKMTDEEKRKNFLERNRVAALKCRQRKKQWLASLQAKVEIFSTENDALTAQVTSLREEIVSLKTLLLAHKDCPVARSNGGTMAALDMNTGMNNDYGHVPMMAGHYSNMTGMGGGVMAPPGAGRRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5I4</accession>
    <name>A0A2T7A5I4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_965665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5I4"/>
    <dbReference type="STRING" id="42251.A0A2T7A5I4"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01443">
        <property type="entry name" value="TFIID30KDSUB"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="18440" checksum="7BBA87E6000E89E1" modified="2018-07-18" version="1">MENQTSSFQTSSSTVPDPPGGLVGIAQPAPPPMPKKDRTLREFLGMMEEYAPIIPDAVTDYYLSLSGLNTSDPRLKRLLALATQKFIADIATDAYQYSRIRQSSSNTGGGVPGVGALAGAVGGVGGAAGGAGAALRPTARPGYGGGGGGGGSAGRTVLTMEDLGSAVGEYGVNTRRPEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5P4</accession>
    <name>A0A2T7A5P4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Beta-glucan synthesis-associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1098894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5P4"/>
    <dbReference type="STRING" id="42251.A0A2T7A5P4"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="242"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU83059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="655" mass="72623" checksum="C309C951EC1D77F4" modified="2018-07-18" version="1">MSSRPLPPPITLNSSTLDLLNQNGNGRHEDPNSSAQSPPGSSPRINPSVRTLTPQSPTVASPRTTFYQQSPLQSSDMLLPPSREKRFQEYADSPTSSRRSSWSTDRGGSAYGPFVSPFDESRGPSRTCSPDPMDTLNSQTISEKYNIMPSDGLLLFPIDKEDDDALHDPLEQDPNECDIWTRRGLVNVGGLAFIVLGLLCLFIGYPILTFVQNVIIESESPCDAGELCIDIGPIDLLKNVRHSLIDPDTPESAKTKKSASGKEYKLVFSDEFNKPGRTFYPQDDPYWEAVDIHYAATGDLEWYDPDAITTKDGYLEIEFAAFRNHDLDFRSGMLQSWNKMCFKGGIIEASLSLPGRGDISGFWPGFWTMGNLGRPGYLATTEGMWPYTYHDECDAGITANQSSPDGISFLPGMKLPACTCANEDHPSPGKSRSAPEIDAIEASVGAIDKEGKIIVGSASQSAQVAPFDLWYQPDYDHVAVYHPEFTSMNAYRGGFFQEAISGLSILNNNWYDGKQYQTYGFEYEPGSEGMIEWNIGDLKTWRMNAAATGPNGNIGQRPIPNEPMAIIANVGMGSSFAYIDFPEINKLLPAKMRVDWIRIWQDEDCEDCSVTCDPPGYPTTKYIEDHLEAFMNPNLTSWASTKYKWPKNTLVDQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5R0</accession>
    <name>A0A2T7A5R0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1098887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5R0"/>
    <dbReference type="STRING" id="42251.A0A2T7A5R0"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="336"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="495" mass="52562" checksum="B02DB3C41666D407" modified="2018-07-18" version="1">MGVSKSPTTTSTTTQTNYSRKHGRDDGINGVSNTGATGGGGTPHKRRKKAVPGPDSDTPMVGGFPETPATVAEEPRVTNGCSVGVQVENTVEITAEDSVILGQEDKSILICAWNPTHPTVLATASQDSIARVWNVPIDATSSTVTQNKVILHDPSNSPKRDVTAIRWSPQGDLIATGSYDGQTRIWTADGLLRYTLPPHHGPVIALKWNKSADTLLSLSCDGKVIAWDALTGDMRQSFEQAIGDQGRGDQTKGGQAEAATDMDWISGRQFAICGNGGSVGIYDLDHDSSLNTNTSHSGEVNCLVWDECSERLASGGEGGDVLIWEKPSKILQPFKLQGHTEAVVSLCWQPIASSSSSPQPARRILASASNDCQVRLWDVLSKTCINILNSHDPVEKISFSPSGTRLASSANSKVTIWNAETGAITHVYDGLKGRRKNGKMITAGAEMDAGIGEISWDKSGARVAIGGGETKVHVLTPASPPAILSLQQQQQQLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5T7</accession>
    <name>A0A2T7A5T7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1073788</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="12">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5T7"/>
    <dbReference type="STRING" id="42251.A0A2T7A5T7"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="13">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU83070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="12107" checksum="A535B135E7BB2AF7" modified="2018-07-18" version="1">MGFQEGDNAKGANLFKTRCAQCHTLEAGGANKVGPNLHGLFGRQSGQVEGFSYTDANKQKGVVWTEKTLFEYLENPKKYIPGTKMAFGGLKKEKDRNDLITHLRNATGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A608</accession>
    <name>A0A2T7A608_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1016500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A608"/>
    <dbReference type="STRING" id="42251.A0A2T7A608"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="515" mass="56650" checksum="034E59DAE8240679" modified="2018-07-18" version="1">MSHLEPRDGSPNTSPRSSLAPRRSSTPRTTPPRRRRVISTSATRRRTIIPRQEALVPPGPPVPPAAPISTPAPAPAPEPPTINPPAPLPFELGDFKDAPQNIFRTAGSLLGFLSEVVFTGLGLLKRPLIYLFYIYLFGVVLCYAFQLAAQSLYRLLSPICAMPGVSLLNVPICEFASTGTGTGNDGNPTSQTDFPRLINLQASFEDILENSAGGNSMALDLKNSEAAVRDLSMLVRVSKLVNRDELSERLDDFVQTAKQASRGLTRFGSKVNGVVDSLLAMDEFAIRSLENAQLPDPHPIASAVSRIVLAPLHLIVSHDPQKTESSILKTFLQASATMDTSIQRLILEAELVLRDLDDLENRLSTIQEMASREDSVIQEKHQEVLAELWSFLGGNRRKLANFSSHRSLLANIATYRSRALAHVSASLIRLQQMQSDLEDLRDRVAQPVMLRDAQGEGEVGGILLEIPLEVHVESIRKGIERLSRGRERIRGGENDYARKLLSQHDEAIKVLDARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A611</accession>
    <name>A0A2T7A611_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sulfate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A611"/>
    <dbReference type="STRING" id="42251.A0A2T7A611"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031563">
        <property type="entry name" value="MOT1/MOT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31970:SF9">
        <property type="entry name" value="MOLYBDATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16983">
        <property type="entry name" value="MFS_MOT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="46913" checksum="B1CC4DF97C00679C" modified="2018-07-18" version="1">MALFTSSFKHNVQTLKDNPLGEIAGSLGDLGTLLPLMTALAAGGSISLTSTLIFSGVFNICSGAFFGVPIVVQPMKAIASIALARQLSLKETMAAGIGVGIVVMLLSVIGMIKKAADMIPLPIVKGIQVGAGLSLCLNAGSMLSNLNLNQSKWDDNLFWAIGAFSMLYGFSRQSKFPFALLAFLLGGIFAAVDVATSGGSLPAFGFWWPFTLTIPTADEFATGFGTAGIGQISLTILNSVIAVRYLSEDLMPTRPAPSVTALGISVGLMNLTGCWFGAMPVCHGSGGLAAQHRFGARSGASVMLLGLVKVGAGLAFGESLTGLLQRFPKSLLGIMVFAAGIELASVAENLNSTARDLLSPTSAALGTERSRSAVYASLRVLTEREKRERFLNMMVTAAMMLASKNTSVGFLAGVFFWALLRLQDRMEDYGDARASFAPLNEASALLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6N5</accession>
    <name>A0A2T7A6N5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_964556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6N5"/>
    <dbReference type="STRING" id="42251.A0A2T7A6N5"/>
    <dbReference type="OrthoDB" id="1738954at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000425">
        <property type="entry name" value="Putative calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="516" mass="57094" checksum="E0092D92D7C720C8" modified="2018-07-18" version="1">MGDGAFSNVYRASDTQGEYGEVAIKVVRKYELNSSQNNDHLHPDFKKAPKTVERANILKEVQIMRGLNHPNIVSLISFSESRSYYYLILELCPGGELFHQIVRLTYFSEDLARHVIVQVAEALRYLHEEKGVVHRDIKPENLLFEPIPFIPTKNPKPRGPDEEDKVDEGEFLPGVGAGGIGRIKVADFGLSKVVWDNQTMTPCGTVGYTAPEIVKDERYSKSVDMWAMGCVLYTLLCGFPPFYDESISVLTEKVAKGQYTFLSPWWDDISKSAQDLVSHLLTVDPEKRYTIHEFMAHPWIRGTDEETTAALDAPPLATPAIKSANKTFTPMVIDPDFSPDMGAPGAAKRMDFRSPGVVSLREVFDVGYAVHRMEEEGKRRKNWRQGYRGGPQPLNEEDEYDSGDDDVDAIFNSEDEEAGEPVKIPSDADDVVGVGQTLRQTDLNAGSTYAGSVAAARGAGVSGLAKQQQASSGSAKQLTFAAPARTKRGKAHGFELSLDNATLLGRRKRQDYPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6S1</accession>
    <name>A0A2T7A6S1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1119254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6S1"/>
    <dbReference type="STRING" id="42251.A0A2T7A6S1"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="657" mass="75286" checksum="F0CEF80F84967452" modified="2018-07-18" version="1">MATVQKKPRSGQPLDSPHYTELINHYLDSGHSTHRSDDFYSASAHNAYDDLLANTSRATVTLMRVPFAPYFDTKFILKLFKTAYFAQAPVEQAELEAASLHHAAEAFRRNNNISRAPRVYVIRADQNYIAQECIPGRGFRDSYPQWWPKERLIKFVRQVAVARLALLSQVENQLGAPRHAPDGRRVGPYCSGVWWENARHRFWNQINRGPFLNRHELILASLRKELLVIRWMRDRHEVLHSSSHFHTWEDAISYLEATIRNIDQVPRPTNQEFFSLNHGDLRDGFNIMMRGSKLVGIIDWEAAAYAPLPICIMDLTNSTDYNPREWRAHAGPNGENFHVLPYRLETENMEGRLERLTRDGAERKPFPDWELIENNGGPLGEEDFYGDDYPEDISSADDESIIDAAEMHCDSDAEAEESCVLPEDPEVPESQRLSENQRRGLAPYELPEDWYYEPVYALMREFIHHQRGAGLGPNGEWGRLPEAYSRPLAEWEDTLYIRATRRYFDLHHSQIIDEDRADAEPRLAKGPRGKKSKKQPRQRRVPTLMDGWRDAAAAGTEIPPESPESSGDSWAKDRAPQRIRLNPPPKPRRVGPNPDPIPVSTLQKEQALKRVKQRGKADPPPVKLPPAGARVRGVRDRIAAKVMEKLRDRLGRGADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A718</accession>
    <name>A0A2T7A718_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A718"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16243" checksum="11DAE98A133F83E8" modified="2018-07-18" version="1">MKKGRRTGEKRGPSVVYSCSPRQPGIKACRSACSRLVMIGQRSKKVILLSSSSWISPCFLFACSFAQQFIHLTYYSVPCLSLPFFSFIRSFVPAGYLPVIPLLSLVAFSSNRSLLNLNRCKRRDKNRPLKKQVAHQLALLCKVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7T7</accession>
    <name>A0A2T7A7T7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1038356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7T7"/>
    <dbReference type="OrthoDB" id="4768051at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="608" mass="67802" checksum="767F4819FCF496D6" modified="2018-07-18" version="1">MPHRQTLSRRPDAPQTPPETHSIEELLIKDFEGPAPESFGSGDLFYSDLLRLILRLFLTFCSLALLVICLWQFSRQGPLDKWQQRCFNTLSILLTGIASLGLGSLVGCLGSMLRWPLLARTMHKMQDVDLILGMAPPTGSLRLIWGHLRKDGTSRTTWIVAAYLIINIFGRLSVAVFGLTYNMMDRTGIEYPILSTNWTSVSWAGYSSDSRALTSVLYDPGVADANSSDLLSELRIENLTLEEPVGPNTVEYSYQLKDYHEGYTILSNHTVHSVVNCSLIEVSRQGQYWRWNNWDRTGPFNWDQKSNEVLSGVLAASNDTNFKDRVDKSSLGVINITVFLDLVCSSLAWECSPTLTETVANQSSQPHQRLFHSASLYALPAAVQLGRSQERYSIVGSDFSLFGFVNLLPVSRSSPNALDGLDLICAQALTMPLDKIRWNTYALWVSGLVARLPILAITYENTAHPQYTRDTHSNHTAGTAYLHTTLEVNWNRVTITAVSIMIGQILAILGVLYYCNSVYTRDDSYLATAELLKTVITRFDGGKLMTGEELAVSLDRALGVSVSYGTRESQDGGPPEVDLASGLDLNFPPLPHKRRFWRKTSPKMPEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7V8</accession>
    <name>A0A2T7A7V8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_754034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7V8"/>
    <dbReference type="STRING" id="42251.A0A2T7A7V8"/>
    <dbReference type="OrthoDB" id="5295250at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="498" mass="57612" checksum="2DF7172FB9A1229C" modified="2018-07-18" version="1">MPTSSIDPQLAINLFENLSPSSRREFLSQLTQKFYPSDWNHIHTLLHRTSFFMDIIGTLSIELTFQVIQHLDPIDTIRIRRVSKRYHEIFTSEDVCRFLSNKLLPLEDNLAQPESWRIYYENRVSRRWAFLNGESHSVEELEHSTTMNMTSFCHKTSQFAYVFDNFTKLQVVDLSTSPITEILQPMFLPNRSRILLIQLLPTHVVVATSMGVCYAWNLSTMEWHSFKLPNARVNSIHGDGNFVAISVLKMLAVHDVVKETTKTYEGEPIDWLWNIVGSDMRFHRLLVDAERKRVWTLTESMPLGKRVVHMLDLSNGATTLKEMVLGPQPGSKVYNWELRDGLALYSGNDCYDFVFNFEVYNQRECTDKAPRASRLVFDLRTGDCYEDVFYLEACGKQIPTDQFAHERDGLICCYNHHFTPDGGEDGLPSLDFFVPGMAYRTPGKKEARFRFLDRPNSVKVGEDRAPWLCNAMSEKFVLLVSHWSSELPVLVRFKGIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8X4</accession>
    <name>A0A2T7A8X4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1037730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8X4"/>
    <dbReference type="STRING" id="42251.A0A2T7A8X4"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="74"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="703"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU84165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="840" mass="93564" checksum="1140862DF065255F" modified="2018-07-18" version="1">MTAVQSSICGSRSGNNNSNNTYQHTSVTNNYGIQVPSYVPATFQELITRTCWWVSPPEIDLDHLRDEDNLAEGDTGKWIFKGVEYQDWWESKESKLLWLCGGPGTGKTTLAKCVAADFLKGLDDSPGRVKMISHFVSPELPADERSADETSADEAELSRRRLAKVASDLLYGILQQDGDLFDSCKAELEKQGEIFFTNPHSLWKVLRKTIEDCETDSIYILIDGVDELKESLCKDVIQRIGKLMKIRRVKIFLSSQDVPHISNNLPCNPSECTKINLDTNSFLKEDVETFIRNKVDAWGWDDKQKEKAKEALMAKSEGTFLWASLMIENLACLCSGPDSDAFLKEPPPKLEDIYQKMLRTLCSRVELRGVLDMIWSVALALRPLTFSELGHTLACIEERARAGQQHLHRETSSKIQRRTEEDIKAYVKSSRGFLRVTGTTVSIVHHTAIKYLLDARRKENLPVLSKSEADLTVSWACFQYLHQAFENVEKLPRGGVEGRQGGCQGSRSGGISQEEEPGETPRDVVPKDPQKAAGKWPYLRYAAESWFIHARRSIEISKDKFYDESARNWFQHQFFEASDIIRGPWIDLCGDPDMEALAGEQTPLHIAVCLGLTPLVEKALLDFTQRTKNHQTPLHLAAKLISGAYGVLVPNSEPFLLTVSDQAGNTPVHEAAMSGHRLMLESLVERLARLDQSNDAINKRNGLGNTPLHLALQFDHPHIVQLLIDNGADQTIKNDAHMTAPELGGKLGREDSLDILKPASMACERAKKETSEEPVEGVVYQIPGKLDGGTVEGAVSKIGVKTGDTGATAREIKASTEPLRGSELLLCIFFTIVLIVTMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9H1</accession>
    <name>A0A2T7A9H1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1060257</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9H1"/>
    <dbReference type="STRING" id="42251.A0A2T7A9H1"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="8"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="356"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU84386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="467" mass="50743" checksum="6695F72EA9A70CE2" modified="2018-07-18" version="1">MAPVSKQYDYLVIGGGSGGLASARRASAMYGAKVGIIESGRLGGTCVNVGCVPKKISWYAAAIAETLAEAKGYGFDIDVKGFDWPTFKTKRDKYIERLNGIYERNLRNDKVDYIAGRGHFVSRNEVEVTDSGGRKTTYGADKILIATGGYPSIPSNIPGAEYGITSDGFFELDQQPKKVVLVGAGYIAVELAGIFRALGSETHLMIRHDTFLRSFDPMVQEVVGKHYEEGLGMKIHRRSKQTKIEKHEGTGKLRVHYEDSNGTGVLEDVDTLIWAIGRKPKTRDLALDGVEIETNGRGHVAADDFQNTNAPNIFSLGDVSGKVELTPVAIAAGRRLADRLFGGPKFAQAKLDYNNIPSVVFAHPEIGTIGLTQPEAEAKYGKDSLKIYETKFTAMYYSMLEHKGPTAYKLICHGPEEKVVGLHIIGLGSAEMLQGFGVAVKMGATKQDFDNCVAIHPTSAEELVTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9L7</accession>
    <name>A0A2T6Z9L7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000677">
        <property type="protein sequence ID" value="PUU72192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9L7"/>
    <dbReference type="OrthoDB" id="5407383at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="127" mass="14720" checksum="A9A35628D29521DF" modified="2018-07-18" version="1">MSLDLDSSYSAPSTWGLYCHVAENRFRASTQEIGERLLGWAITPKDCFISPEDQQDSIGYIITKRKRLFASNTRLIIDLEMAAREEAEEQGIDLEEMDRIDREMDRQALPNLSRQQFPRPIKKEPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9N1</accession>
    <name>A0A2T6Z9N1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000672">
        <property type="protein sequence ID" value="PUU72198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9N1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015401105" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="135" mass="14040" checksum="740511A76FBA6B05" modified="2018-07-18" version="1">MWTDLLPTLLLLLSIAVQAHPLGGLIPGFKGGSVLLQGYDKDGCPTEPNFSATIPSTLLGCTPITSTGITNVVVVANDKLPSTCKLFLYENANCGGTESANIGPIFPSSIPSACIGPIRNPAGNVFELKSIHMLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9N9</accession>
    <name>A0A2T6Z9N9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1097940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000704">
        <property type="protein sequence ID" value="PUU72156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9N9"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9N9"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU72156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="13049" checksum="9174F184A8C979F9" modified="2018-07-18" version="1">MDNQVYFELYRRSSIGVALMDSLDDLVRKGRITPQLAIKILLNFDRGIAEILASKVKARLTFKGHLDTYRHCDEVWTFLIKDVTFKFPQRNVPSVFARKIKIVCCNSKKAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA04</accession>
    <name>A0A2T6ZA04_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNAse P Rpr2/Rpp21/SNM1 subunit domain-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000569">
        <property type="protein sequence ID" value="PUU72331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA04"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA04"/>
    <dbReference type="OrthoDB" id="10478768at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="19594" checksum="D3DB73BFD7BFA128" modified="2018-07-18" version="1">MATKTPPRPSSSNLTTSYILRASHLLLPTAPSLSTTLLSTSPAAQTSPGLSNICKSCSAILIPGWSAHVRTLPHGKEKRKEATASKTTVVVWECQSCGGGNRFEVGKPKIKRGKGKGGGGVKKVEGGAGRERKVDRGTNQGSKARAKKRKGSLADALSKRRTDGGGGGGAGAGAGAGGFGLELMDLMKVGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA31</accession>
    <name>A0A2T6ZA31_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1117805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000578">
        <property type="protein sequence ID" value="PUU72319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA31"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA31"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU72319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="21929" checksum="CD2B9D550B6CE608" modified="2018-07-18" version="1">MVLLDEAPEFLIHEVLSNFNISSDMHSVARINETLARITSDREKIKDDEQTTLRALSRKMEISKQSMEATASAAGRKEHGANMLRLDREKFALAKGINELESSAHGLEGQLARLKEELEQVDGEDPMQSALVEAEDGTLLKLKVYRSLGIDLQEDGAAGYSKAVIRNSSKGDIHVVNIERKFSHFFYANYFWNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAD1</accession>
    <name>A0A2T6ZAD1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_684471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000552">
        <property type="protein sequence ID" value="PUU72384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAD1"/>
    <dbReference type="OrthoDB" id="5414418at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="18979" checksum="AC8383C29837358B" modified="2018-07-18" version="1">MSFFRYSGLLKMTMHCCPPLHWCYDLPNCLSPSDEIRLLPRYYSFLSSRSRFSDNDSLDEMDPPSFQYPVLTLNDDEGNDIGSHNSARDDSDISVADDKLATLEWLSPLTPRDRHQAVRRGRVDGVGDWLLQTPEFMKWHKSEDPHAGQVLFCYGAPGAGKTCLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAI9</accession>
    <name>A0A2T6ZAI9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000520">
        <property type="protein sequence ID" value="PUU72495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAI9"/>
    <dbReference type="OrthoDB" id="4638065at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="134" mass="15877" checksum="BE2D70AD041DC471" modified="2018-07-18" version="1">MKQEAEAVQTNGQSTSRHVFGSNCKMVEVFFQIHSYGERAPPISRKATLEDTQALGSNFEQIDIRYKRFYIRDYVEKSMSWNMEEYASVNPPAIPKDPRHKDYEEWLLSHPHLCWPPWAWAGVYHWGIWMEQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAL0</accession>
    <name>A0A2T6ZAL0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000515">
        <property type="protein sequence ID" value="PUU72528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAL0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="17380" checksum="7144B2E5EC748743" modified="2018-07-18" version="1">MWLGFAKKTREVFVLNLYRTITRSLETQHSIWQERREGFMDDNDAIYPELQYQLDSDSHGEPARRRQTPIDALVRSLLMLVNLKSGFLDADPAGLEDRCRQTEKLGPENVRSPHSFSSLSLSLEDFEAGKASLGGGGNIQQDAEGGQEVVGIKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAS7</accession>
    <name>A0A2T6ZAS7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000515">
        <property type="protein sequence ID" value="PUU72524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAS7"/>
    <dbReference type="OrthoDB" id="5399568at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="281" mass="31223" checksum="DEE8740FBBE58F32" modified="2018-07-18" version="1">MANTRGSRKREAGGQGQGQGKRTRRKLTELKTSNKPTISDAEDEDNDSGGEDPEGGGEDGDSQQGAMILFEEKLKAMKKRKTSSSNSHVSKFRKQVKSEQEKLLSALDDRRTQINSEAADFSQLFIGLIEQALESPIEHDSGDLTDDPSLFVQSHPLFSYQESVLSLSKTVTDSVESVGKTLVPALDRDLELGRGWERDGTDAVDVLLEGRQSTHDRLLATIVEGYNGDKAQEGSEKDPDIEHKKWKTTTRKARKGVRKLMNSLNVPLPDSEWEYFRSQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBA5</accession>
    <name>A0A2T6ZBA5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1008187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000467">
        <property type="protein sequence ID" value="PUU72777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBA5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBA5"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="17147" checksum="02265A416492829B" modified="2018-07-18" version="1">MSLVNLGHFCSHMQNASRAGLSITAIMSSKLHLGIALALQDHGFISSVTRGDSAGPDAEETPTTQENIATRRLWISLKYYDNEPVLSKMKLVSKPKKRIHMGIQGLQKLVAGEQHGFVQPLEAGEVMLLSTDRGVIMEARQAVERRIGGQLLCRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBP4</accession>
    <name>A0A2T6ZBP4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1111498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000443">
        <property type="protein sequence ID" value="PUU72917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBP4"/>
    <dbReference type="OrthoDB" id="5400171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015686333" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41411" checksum="47EBCD7341C446C5" modified="2018-07-18" version="1">MKKCIALGAGLLPVLVLGLTDGEALEKNLDSVFIGTSVATWKDKSYPGCGERSLGTFKDTVLKFGPKRDATGAENTYYIFLRSPEPEASRVSLVSSVTTNDQKQAGWDVGFEKGTDGYSVTGTLVNEGVGENNIKGTFDKNDTGWCGFRIPNWDWNAAKGTKYEGFIKPGNADFNLSGESLDKDTQRTISYEVKFTGKWSDSSAKLKTDKPEPTWEAPGEDNSSIANGAATITKDANNEAVTADAKSTKGNGQHNSPQETSRVAGTQGVKSHEQIIEESKAAMAKGHVVGVAVGALFGATIAVIGMFMFFARRRKKQKAQVYPELAYIYAPSPEPSVQSGSSESGSYRYDRTYKAGSPESKYERREVPANEVVTRQTHWNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBT0</accession>
    <name>A0A2T6ZBT0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1136489</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000450">
        <property type="protein sequence ID" value="PUU72874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBT0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBT0"/>
    <dbReference type="OrthoDB" id="5371797at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="278" mass="29929" checksum="E7B289230DE41779" modified="2018-07-18" version="1">MHFPEADLQIIQQNPLEDFRNTYRQFFLEKTDLTVEKVQEKPDILKLILNDSTTEENSRELFHVFLLQLSLTDASGELRHPTGSDTITRKRILLFAGEWPNQLEIDGDALGLCADGLFKALAPETDVLDQDVWSSVYNLLTAFPATDSPEARKNVAIMARDYLTKYAKEHPYLLALNIGLSLAGFAVPPFLGALGFTGAGVGAGSAAAAWQSSFMGVVPKGSLFAACQSIAATGSAPLISAAGWATSGTITGATAIWDSMKGGRDPNKGKSESEGEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC07</accession>
    <name>A0A2T6ZC07_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1069301</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000423">
        <property type="protein sequence ID" value="PUU73028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC07"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC07"/>
    <dbReference type="OrthoDB" id="5350302at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015612032" evidence="3">
        <location>
            <begin position="25"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="44"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="624" mass="67825" checksum="13DF9C2C546A9642" modified="2018-07-18" version="1">MAPSVWGVSMFLLLQGFLIRSTLAVRAIHVEFGKPLADNSTDDFLFPLVIGENDAKQTVYLAPSTNNAHTFAISPKACTPPGNDTAWPGCVKYRGGVFDPTKSSFKPGSGDSTKLDWRNDQYTLFADGVYGQGTITLSDKVGDVQLKDFEVGLVDACNMTSGFLGLGPNSTLLERLYKDGTIESRSYGLHVGIDITNYPYPVFDPTFDTGEKPKEESDYNSGIGKRSRVKERAEEVTPKEVHSFAGGLTLGGYDRSRIDNRTASLTVPLSADGLLELELTEMIVINSWMVNDSPAHDLFNETRKVIIDSSTPYMYLPDKTADALSYSMEAYYGDPMVDFFFGSNPDKYLGNVTFTLQAPGGSESIKIVVPPSVFQQPIGMLRDYQPVGDGYYDYYMPIKQFKASSKQPIILGRSFLKAAYIFVNHEQKNFHISQVAYTGAPNDIISISASDSGDYGSGTSSTSSGTGSGQNPSPGPETRGPPVVVIAGASAGGAFLIALIAFLIWRRRNKPKQSQLRTIPSNPSFHENELDGSHALVQLPANPIEKPPVAASSPYPNDTKPGWNTQPPQGHYEMGNGVGIAVSPYPAYGYPQQSVPGYAELATPLPTRQQQYQAGSVQGRYEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC17</accession>
    <name>A0A2T6ZC17_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SEN1 N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1136038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000423">
        <property type="protein sequence ID" value="PUU73038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZC17"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="11">
        <location>
            <begin position="1852"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="973"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1788"/>
            <end position="1845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1864"/>
            <end position="2011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1400"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1866"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1893"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1921"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1935"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1980"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1998"/>
            <end position="2011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU73038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2011" mass="225218" checksum="7C7A638B511AD500" modified="2018-07-18" version="1">MSATDTLDIEDIESGLRLVHSLPEQVHWLCDKIEKRDDGVEVRYEGDKSRRNRSVTHAMVLLSFADQEETQAWFTAALNIQLSRCPRCVEQFYVLKKGLYRELLEADNKDNVDMFFGFLQTCDINRVKPVLKEIAGELKNSSTVESWYQTFQNRAQYTNSVYQVFCCPDLLQDPEIRTDFTDICATQKVFPEGPGAGLISLLFNNDARLRFPVERSWKELGPHITPEVFETHLLDTLEDCVQKTEAQADPGSLRLFFAGVAIIVQSVSKELIMKCICGAQNDPIKLAVNRISTNAPYLPALLRLFDALMVQLGFEFWDVVQPLTSSALIDTLFMNGTFANFLRNAPQDASGEKLLVDMTKWMSSLVASVRPLSRATPAAPLLRLLLGDRSLPALSKGICLKEGMKILSMTLSGVFSHPIEGEGGRMILRQTNELFDEYALLAVEIAVSSTVFNDRIMASHMGIAQKNAYNAMLLALQLDIKVMKTDFGLLSKKKPEIPHTETSIRTLLWDTVCKNIPIDHVELAIDLLSIIYEFLGIGKSVHPKGIDTGSEVDRRRHAFNTALDILSRHFARIFQRISRFAPGKLKMVINGEHSRAAIFFGVMFPPPTDVAFGAEDIMLSCYGADSRESATHAMFDENLAMALAAVTTISRTQAKSSVFDLMPAMIRFNLEVLDILCAPDTGVISNTEMENWMKTSFKVYWDIQWRVVSNIFKRCRRWSHTVEKGTMIEFTRDSIDYATELFRRFWTFEQAFRAKVPSDEPNRPQRETSWRVRLLQDPSKALDSIAALLTIQDMHLLSSSQELMCNILELLAKEDVDVENEFVDNMRRIFFPELYNNARTGSATNLVGAQKAQLMHALSAVRPDFVPLEAKPKVVEISDDEYDDIPDDDLIQASEQSLRVVPRKQTKLGFPAASAPPTHEQKLHRVGVSKPSSLIEELRIGAPKTQSTPIPPRNEFLLKRKADLAASEAAKAARLESRKKEQAPVIPSSDEDDDSSDNDSGNGLFRLGTSVQRSTKSVPEPKLIDARPKNLLRQPAVPIRRVKDNRARVAPDLSPLYKQVLKWEFFHDDVFPPGLSAANYSKVESSFSSYAAYKKTFEPLLLLEAWQALKQAKEEAPQSTIKLHLVTRMSADNFVELEITIEGMNDRNRWSESDLVLVSVSNQPLTSKDSPHCLARVHSLKKKFAGANTTEVQLRCDPSPQMTQENMRNGSTLYAAKIMGFVPTEREYSALMCLKYYDLEQEILTARPSSLEEPTEKQVVRTRSLYGVNDPQARAIISAVKNTGFTLIQGPPGTGKTKTVVGIAGALLTPKVGSTVIQIPGSANRSPKPTTKKLLVCAPSNAAVDELVLRFKKGILTTKGEEMLPKVVRIGKSDAVNFTVRDVTLDELVERRMAPTKESANSKSADMDELRQKYRAILDERDAKLKQLEDARAKSIDPGTLQSEVDSLSATIRDTRRNLDIKRDQKKESSRNAEVLKRRIQQEIMDEAHIICATLSGTGHDLLRNINVDFETVIIDEAAQSVELSALIPLKFGCEKCILVGDPKQLPPTVFSREAAKFSYEKSLFVRMQENHPKDVHLLSIQYRMHPMISAFPSEHFYDSELRDGENMRELRTEVWHKNPIYAPYRFFNIAGQESAGGLHSLVNRQEAQSALLLYQRLTTDFPQTSFDGKIGIITPYKQQINLLKTVFREKYGDKICDTVDFNTTDAFQGRERDIIIFSCVRASQENGIGFLSDVRRMNVGLTRAKFSLFVLGHSTSLMRNRLWASLVQDAKGRGVFDEETFAQFNLNTKGNGARGRGAFRGSTRGRGGHARNPNRNTPTLAAPKVDPDAMDIDEPEPQAQFQPNPSHVRLCFKCKQPGHIANFCPNNRQGPSNPSRNSNSPRPKPTPPTAKGNDHIQDQRHEHPPQEHNQLPARPLKRPIGKEGEVPSKRQHLENQPGTANQATPGPSTVPVIRPQHKKKAQRKSEPPAVFINPKRGSSGRGGRGGGGRNGGQPSRPKGDDKQGSDQTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC27</accession>
    <name>A0A2T6ZC27_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_927639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000421">
        <property type="protein sequence ID" value="PUU73048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC27"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC27"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="10585" checksum="858FD8E708B096BF" modified="2018-07-18" version="1" fragment="single">LRKWSRYCVHAVVEDNLSTTAEHAFTATGFSVLLQPIAGLYELPDWPRMQDSSGTSYRWQFGGNVGSKMRQVEDWSDENAAEVEPVCCWPDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCA1</accession>
    <name>A0A2T6ZCA1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1095719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCA1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCA1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="12838" checksum="F1ED5F59686173EA" modified="2018-07-18" version="1" fragment="single">KVDAKWWLENPEGAVGTVVIVTYSMEKRSVCAETWELADVANPDVTQTYPDPFITRATRTGGCKIVGATVTGAPLKISFKKTMLRDPEKSLGEGDIVFDAKDIEGFAKTVWAALEWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCH3</accession>
    <name>A0A2T6ZCH3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1095759</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000411">
        <property type="protein sequence ID" value="PUU73114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCH3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCH3"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="327" mass="35559" checksum="EBEACBF5056F3347" modified="2018-07-18" version="1">MFRRAISSLASISPFFSAASTKSIMTSPLKRPVKLALIQLATGSDKDVNLKRASEKVAEAAKNGANIVVLPECFNSPYGTEHFPNYAEPIPTPTRTFPTSETPSYTTLSTLASTHKIYLIGGSIPELDPETSELYNTSLTFSPTGTLLATHRKIHLFDIDIPGKIKFIESDVLSPGSTPTLIGTEYGSIGLGVCYDIRFPELAMIAARKGAFLMLYPGAFNMTTGPLHWELLARARAADNQVYVGVCSPARRKEEDGEGYTAWGHSMVVDPNAEVVVATEEKEGIVEWELKPEMISDVRKGIPITGQRRFDVYADVAVAEPTRGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE01</accession>
    <name>A0A2T6ZE01_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1196710</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000349">
        <property type="protein sequence ID" value="PUU73727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE01"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE01"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU73727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="449" mass="50203" checksum="DE5FE442CC1AE575" modified="2018-07-18" version="1">MREVISLNVGQAGVQIANSCWELYCLEHGIQPDGYLTEERQKGPQDTGFSTFFSETGQGKYVPRTIYVDLEPNVVDEVRTGTYRSLFHPEQMITGKEDASNNYARGHYTVGKELIDQVLDKIRRVADNCSGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKCKLEFSVYPAPQVSTSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLDIERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYAPVISAARASHEANSVQEISNSCFEPHNQMVKCDPRNGKYMATCLLYRGDVVPKEVHAAVASIKTKRTIQFVDWCPTGFKIGICYQPPQLVPNGDLAKVNRAVCMLSNTTAIAEAWSALSNKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVATDSLGEDAEEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZET3</accession>
    <name>A0A2T6ZET3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000328">
        <property type="protein sequence ID" value="PUU74001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZET3"/>
    <dbReference type="OrthoDB" id="5424069at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="236" mass="26961" checksum="CDA6EF58984C6D25" modified="2018-07-18" version="1">MPRNYEIQPLSLDEIQARVVYALTEVADLLCPYHSHKVTGKDLPQGVDFPWYTLTVPCCENDIAWEIEIFPTCTLKSVTRCKRVDLPNSPPDGPPLKFLQPRLVWGEFSCNEIVDMIRCPGPGEGWWWLDEEILKDNQPSDVFPPLSADADNKQDMKPKGSESRPPEHAADGDAACSNEAPGRSYQPPSTKHEDDYELQPWYGTDTEQEHDKECDYVHLPGMPPEYAKYYRVQFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFR2</accession>
    <name>A0A2T6ZFR2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone chaperone domain CHZ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1133485</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000306">
        <property type="protein sequence ID" value="PUU74341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFR2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFR2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019098">
        <property type="entry name" value="Histone_chaperone_domain_CHZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36899:SF3">
        <property type="entry name" value="F13K23.8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36899">
        <property type="entry name" value="OS04G0395700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09649">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01082">
        <property type="entry name" value="CHZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone" evidence="8">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="115" mass="12238" checksum="156E0AFD704B2580" modified="2018-07-18" version="1">MSDITSPSGPATENPADKGKGKAIAPEEEESDSGEDMDQTEAEEDDPDVEDDDLAALDTSNIIAGSRTRGKQIDFAKAAAEQPADEEDDDDDEYHAPTEETAQHGPGDDGMDIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFS0</accession>
    <name>A0A2T6ZFS0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1001109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000311">
        <property type="protein sequence ID" value="PUU74264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFS0"/>
    <dbReference type="OrthoDB" id="942095at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000434">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="478"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="716" mass="79865" checksum="96711D71E2102B29" modified="2018-07-18" version="1">MPPKSKAEVQKQRAKLANSYHELLSEFSSKDLRTVGNYNLGRLIGKGSFGKVYLATHKLTNGSKVVLKSAQKDDANLAREIHHHRQLVHPHIARLYEVIVTESLVWLVLEYCSVGDELYNYLIKNGRLTVDRTKRIFAQLVGAVSYVHMNNCVHRDLKLENILLDKHENVKLCDFGFTREYERQKLLQTFCGTVCYSAPEMVKGEKYMAHAVDVWSLGVILYALLCGELPFDEDIEDDTKLKILNDEPKYPDDLPEDAVSLLKACLKKKPGLRPTLDEVLSHPFLAEYAPAQKAILVIQPSPAFSTRLEKDTLHRMKAAGVDIDQVIENVLAKKCDALAGWWALLIEKEERKERRRQKRKIESRRMSAASNLDPTLLPLNEESEDQMRRQNPVIILPERNLGRTPRGQTPPSPSPLPLANKDGDFGPYLKPPQQDRQAMSSPDLHSEANGGKGRQNRKHALMTQLASIKHWFLDSAKRATSPNSKNNSNQNSASHNGNHLYQQFQNGLASRSGNGARRNSRGNAAYNSSYRGTPPPKRNSLSPGPLTPHTSYRRPSGRGLGGRNSTSSSVSSIRSFHNKTHSKASSTSSASISSITLKSPRSPRGSIKVLPATPTSSTFPSHVRVVRSSSNGQGYNEAAVLTPGVAFAKRKKSPFKGPMLNQAALHAKRENAGVRIAQKRSRGNIIEEEDEDIEEVLEFMGPEESEDEDTLRGRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFU0</accession>
    <name>A0A2T6ZFU0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1056383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000306">
        <property type="protein sequence ID" value="PUU74339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFU0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFU0"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="279" mass="30103" checksum="3CD3E387EA5B2168" modified="2018-07-18" version="1">MAPLQTSQQTGTPLSPAELSYLHTSLTLTPPIRPDSRTPTQFRPLFAESDILPSTNGSARMIWGDGGECIVGVKAEVEKNSISSGGPRDWIETNVEVSGQRDDDAFLGMTVAESLLVPGSGVLERLVLGERFHWKIFVDILLLTPPLSHPATLLTLTTYLALRNTFLPKLVSEAAEDPVFDDDWGNGLPLYPVDRIPPPITLLVVNVGENIFFDPTREELAVGDVVLAVSICEKKVVGVRTLEGGSGGVKREAVKRVIKESCEVAEEVFSSLNGVGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGT3</accession>
    <name>A0A2T6ZGT3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1103323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGT3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGT3"/>
    <dbReference type="OrthoDB" id="2152896at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="54554" checksum="9ED2330FF4199FCD" modified="2018-07-18" version="1">MAATKDSLSPRYHPPSTPNRPPALHIKDVPVKTPPPSSSSSSHHRPPLVSSGSSHRITRRKSMSSTSGANIAAVVQAVKDGGEPPFALPVPAGGVGKNLGRSPGSTKVLNGGVGVGGMDGYPSPPSSLPTAGPMNGGIGGIGGAVSGIAFTRKVGSLVGGGDSAIAEGHASDVGRPARSRRASEGAHVHLGESGDGVGGRVSRARSGSELKCDKCGKGYKHSSCLTKHLWEHTPEWSYTSKLLISKHQQVQLLEAASILVSMNPTTTPPASSSGASNNESNSSTNDSSSSSDDTTPPPSVFSGSDATSPLPTPRGIRNGAGKPGKRYSSGSHSRSYQAPSGSGALSGSAPNSTAFPSHFSHHRPSRPRAGSSVSSIRGSHMTSPAIRPTTITPEDEALAAAIELLSCSFNTPVMGPTVPLGSVPRGIAGLSSPPVSGRPGFLGPPLNDVVEMKREEGEEGDDVRMEDLEERRNMMMEEDGDEDGEEDEEEGEEDEDEDEDEDDERVWKGRGRSEEEEDGVFGQMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHN3</accession>
    <name>A0A2T6ZHN3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_378931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000257">
        <property type="protein sequence ID" value="PUU74993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHN3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHN3"/>
    <dbReference type="OrthoDB" id="5394863at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="393" mass="43357" checksum="17A852CF17F9933D" modified="2018-07-18" version="1">METFLHSLVHLGPFPSVGKSSFFVLMDGFKETIFSVAMPATIPGEQMGAPTAPACNSLGPVITPHPKIHIVEYEKMLLLKLQSITHCGLGAFKTPTFLLNPSAVIHSKFEKGRAHLPEIIVQPVESLAAGHIFDVNQEFFHMIKTGDGYLWRGWKGKFTPNRKDNAVKSSGAAFGQSKSPDGKEIYSWCKLDCCRRCFESFESRKEQGSHEVETPVEVKTPAEEEDDDDDDDEEQEQEEGVENGAAVVVKDFLCTLPQLECCPLKLKASVSRSNSTSSNSSFTMSDNSTPSTPPTMPCTPIMNSVDKRDLVEKYNLNQSFENALTAHLSSQQSKASVHHMLSVFDFPQQDPKRQSLYRKWSGGNRGLEALNLECGSQAVGGDTPITFLSSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIZ8</accession>
    <name>A0A2T6ZIZ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000230">
        <property type="protein sequence ID" value="PUU75452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIZ8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015402886" evidence="1">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="9747" checksum="2AFAB57EB1813905" modified="2018-07-18" version="1">MAVQHQKEVSLRPFSLVLQSLLKGLFLCQVILASEDIRDAIIQSSYHVIVHHSSCPLLNEHLHTTIFHGTTEFSEGSRILRALGIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ51</accession>
    <name>A0A2T6ZJ51_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1131175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ51"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ51"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="405" mass="45422" checksum="E6FB4AE72FA0882D" modified="2018-07-18" version="1">MPPEVIPGTEIIIAVMGVTGAGKSYFIREVTGNSEVEVSDRLYSCTRKAQPYSFEYAGAKITLVDTPGFDDTLRDDMEILQEIADWTSETYRNDRLLSGIIYLHSITDTRMTASAMRNLRTFQSLCGQEALENVLLTTTQWSSVNPVEGQVREDNLRVKGLWGGLIDKGATLQRFHGTKESGFELIHKLMSNTRKPLDIQVQIVKQNMTLLETNAGKCINEELIALEKKYEKEIDSLEKELQAIIEANGDEARRVLLEERARTQNKLEEAQAGMKLLAELHAAEVKKREVGEEARRSDKAVIAIATKDIAITADIAGVITSYKTRGRLIFDFSNHEEFESNTIEITINFKVNFLSRIRAFTKTSRVFDAGIDGTNYIILNGVYYQRKSGTPISVGSQEFVIFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ64</accession>
    <name>A0A2T6ZJ64_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1131184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ64"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ64"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="293"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="307"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="448" mass="48507" checksum="A56CC656896CF525" modified="2018-07-18" version="1">MSAATASQQQSSSLNTPGFFTAAYNEMNIFEQCFSAAAPSDLKNNNASTTPSSGSINTTSSSPTAAPTQAAPSSGRLNSITPASASHVPPLSPKSTTMDGYSPSDFTLPTLFSGVDPTGPSREDMERRYGQNRWPTHMDTTVVPPCVIQPHLSPPYSPRSRSPTDRFMRPVEMDPTMSPLHNMLVNCSTETRSAHGQITPPEDPAPLTSRPQGGGMFDDDDDDDDFLNDEYTIITDTTHSSSRNSQTLAEAGSNTSSRGSSGAVGRPRTRTNNRGGTNRRSKRTGVEDDSVKEAKRQKFLERNRIAASKCRRKKKQWTQNLEDTAREVQTASKNLHKQVAALRNELLHLKGELLKHNGCSCERIKQYLMNEATRVVEGSSASAGINNAAAANSSSSNIALHQASRQRQMSQGSDLGFSAQFDDLSDTSSIRFTMDSRSPEDTGVGMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJJ6</accession>
    <name>A0A2T6ZJJ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000219">
        <property type="protein sequence ID" value="PUU75668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJJ6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="104" mass="12029" checksum="304077B614D89E35" modified="2018-07-18" version="1">MCKKDLVIYFLFFFLLLSFLFTTALYWLFTGFGSSASSLSFNDILRSDVQRAVMISIWHYLGLSFCILLFAKIKINIYLKICPSPLPSIYLFYHTSAHHLQSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJP8</accession>
    <name>A0A2T6ZJP8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1089891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000219">
        <property type="protein sequence ID" value="PUU75676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJP8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJP8"/>
    <dbReference type="OrthoDB" id="26740at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15413">
        <property type="entry name" value="PH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="271"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="750"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="684"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="866"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="934" mass="101979" checksum="4C074B8EBFB6D114" modified="2018-07-18" version="1">MSSFLSFLIAYLLGGITLLPLLLGLLFLYVYLAFPIAALDEPVPELKLDADDDKVFKTDDEKLVKRLNNSADVAAGYFAVTREFVPGGVNGKPPERTSPAGNTQPVSESPSVYQTMYRSLFERKGSPATADAAKKAGRRARNEFFVVLRHGHLMLYDDSDQSEVRHVISLSLYSVSIYGGGEEIPEGELYIRRNAICLSRRSNAVDKTLDVGQNAMPFYLFSENCSLKEDFYFALLKNLEKSDETITPPIPLRYEQKHILSLVQRLHSSEEHLQTNWVNGLLGRVFLAIYKTSDIEKFIRTRITKKIARVNKPNFLSNIVLQKVHVGEGVPSITNPRLKEMTVDGDFCAEADLTYDGNFRLEVAAKATLQLASRFKPREVNLVLSVTLKRLEGHVLIRIKPPPSNRLWIAFETMPKMELDIEPIVGSRQVIWGPVLRTIEGRIREVIAETLVLPHYDDTPFTDTLYQEFRGGIWEEPTPSEPSEEASAAERGSVDGVEKEDNGEAPQTSVDTPLGEALDRSASMPSLPQATLGIDSKKAASTIGLNDNAEGSRGLKSPGLKSSNGERKKKSSRAQITSMAPSSPVVGTDAVNVTAVWGKDNVVDKGTATSAVMAMSRSRSSSTPNSPSTNSHPVGTPPSKLSQNSELAVEASNDQRSEKSSRSSIYSQAETDEPATQADKDSVRPSTPSGSLSNSPTPSFISRTMTNASSSSSTFNSLPINRTTPEKITVAAVGSLTTAVRNWYKSRNVSGEVPTDMSMPSARRLPPAEIPPPPTKKTPPINVPKRKTVPPPLLPARNKPKRQVPAPPVPPRNVGTAGSDELLVVAAPDSEPTTPSSAVAEDGDGYMGRGESEGLGSHMMFPGNESSSPSTSVSPGMPRRRSPSPRLEEGSSWEPDRKRLSKRNADEEETEQWHAAEEAELRTKVPWEPDEALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK59</accession>
    <name>A0A2T6ZK59_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK59"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="58" mass="6555" checksum="7D24955CA1EC2884" modified="2018-07-18" version="1">MLEIWVSAGPILLSLLKGKEERKKENPIVYTCVLYVVGKKKKSRGRHPDDDDDGNEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKL9</accession>
    <name>A0A2T6ZKL9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1195068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU76023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKL9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKL9"/>
    <dbReference type="OrthoDB" id="5421842at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563:SF4">
        <property type="entry name" value="ASPARTYL_ASPARAGINYL BETA-HYDROXYLASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1158" mass="136192" checksum="D215D8509A5C3B99" modified="2018-07-18" version="1">MGLGGPPLPKHSSNPKDIPPPPPPHSSQPKDNPPPPPPHKSTPSLPSPNYEVFIVPQNAGGGIVYLPSLKTHRNSFIVGVISTLVVQGLLKLLAPVFRYYARSFGGLIIGILLAGTGGWFASQYWNNGGWSTRSGGEGGKDRGEYFYKSSSSTNTKQRRAGGEGASTSGASTSSGSSSRHHSRSRPSPPTDSTATNTAYSEDYDKSSVDGQEEEQKFTAAIGKERKAKEERSEKKEDTRVPVPPMPMPTTNNVTPPPSPPLPTPKTPAKSKAKMDRERREKVEREKDRKEKERKEKERELERLAKEKEARERADREKADREKAEREKREREERERQEKERKEKERKEKERKEREDLKRQQEKERKEKAEKERIEREKREKREKLERERLAKEKLLREEQERKDKEQQEKERIEQERLDKERREKERIENERLQKERVEQERQEREQWVKDRREKIRLEKERREIERQQRETEERLERERIENERLERERQERERLEKERLERERIEKEKQEKERQEKMKLAKAAREAKEKERIAKEAAERLRRERERKERAKLDKAQLEQERVAREREEQDRIEKERLEKERIEQERIAKEKEERERRAKEATHRVRAEKERLARQRAEEKERKLAEEKAQREQEERENSAHYKMVKEKEKAIREKLEQDRLQREEAERQQEAALKEEEEKLEQERERLAREVAERVRRENEESEKFRRELMAEVEASRIQIENEKREKEEKERLERERIEKEKEEKEAKQRAAAERLKLQREKAAAKAVERERLEKEERERIEMLKVERERQEREQERQRVEHERMGRAEWERQQQHHQQKLARERSKRDSWERERLPSTPKRTDSHSPSKAAYQTPPSSNRRPMSDTTNLPPSPAKPTTPVPPRKKSFHEHHDSLPPAPPPHRVLSSNSSSTSTRRSRTPPPPPPPPHSSTSSATTSPRPLPRQPYSTSDPSKIVLKAVFMFTALQPLKPQSTLIPGHGGLSEGLILKMTTEGLFIDDAVRNQAQREWDIKAWTIRLIEIFCPRYVAPPAPSTSKEKPSNPVRRLFNQTSSADKGGPTEEEMDNIVDGIQRCCYRDCFQLKRGGGLLGGTHVVRANIRDGEGTRYVFLVDEEEGWKIEEGMRRLRGGSLARALVVESMGREEAGKVLRSVHVPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKU3</accession>
    <name>A0A2T6ZKU3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S1 motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKU3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKU3"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22493" checksum="A6204CF894FC5B8E" modified="2018-07-18" version="1">MGSDKKRKRPPDADLGPGRPSPASSKPELVKQSTLRASKDEEVSFLRGGGSIATPLEFKQISNDAAKDVLFEAKNMKAKSTKKKKKKPTSEGLRRDKKAKKDESKKGEQKGIKVEGLSYKRLLPGTLMLGCISQINQTDLTPSLPNNLTGFVPLTSISESLNEKEGTNNAKSPQFRHTEGDNWASSRKSSLVRFQLTREYGNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKY8</accession>
    <name>A0A2T6ZKY8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1116038</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKY8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKY8"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="250"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="739" mass="83718" checksum="BB0F751ED060752E" modified="2018-07-18" version="1">MSRYLTSGKIALLALVELYAESRFPNQSVVPVLSFVIRHLVSPKENTAFILTLEHIKSATLHQPSAVVGRTIFDLLLKKLWEINSFDALHTFFANIQTYLIEPERADKSPVRVHGEKSMLSRTSVLGCFVRRAALEYVRLQFHDAVSLWRSFIAYREPTLAMWKKRNLGAGPMSFDVNLKGMGFSDGVVGVVYGRGKESRDCTVSTDDVERLLEFQVDSMQRMGTRIPDDMQAQLGQMLSTNVTTPALTHYVEFLNSWRSGDYPGSFDNLHRYFDYTMHNRDRTFYQYALLNLAILQADFGCYRESILAMQETINTARENKDMACLNFSLSWLYHFHKAHPQDCPDVISSRMERESLQFLKAKAKEGGMHHLQSMAHLSEAKQILVGGESIPAAFESILRSSHLNVTKNIHNAMGSQILLQSSLWSRMGISYLSWMNCELFLSKYRVDSPIEDVVKALCRSAYIMSLRGKADEALERLDQVDQECLRTLKVYQYWATYVGLLKLRQAMYKGDAAAAEMLLQQLSASPYVEPDCALEISICRLDLLARRGNYSAALTAIAQLSEELVRDRADIYHRIRVMVIKADLLSKCGRTVKGLSVAISAATIAWRSRLLPALFQAFRTIANILIHMGEFSAAYSMMDNIMPQVLECEDAYLNAQCFSCLADAQMGLAGAKKGAGRNECLHRALEFIDRGFAEYSRIRDTKSQMTLMSQKARIQDFTGEKSLRDDAVKWYKQLKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL60</accession>
    <name>A0A2T6ZL60_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_263738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000195">
        <property type="protein sequence ID" value="PUU76225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL60"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="254" mass="28328" checksum="99F037B49A68B0D5" modified="2018-07-18" version="1">MQHSVTVLFMKGVRGNSHAWLDSCPEDRRGEMKGGSTGSKTTEQRPKERESETRLLFDQAEDPSCRSPLSASTADSSSWLPQVWALNDEQLNVAVLMRPEDFVAIPGFIEVHATVPLVKFTPASLLGQYPRNLSGRAGDPRQQVRPWHRNLEPSFNRGLFIINRGDATDPAFGHPRHYLKEVIQLSQVHTGQRGIRTLEIRNGGVSGLGKNLATMPIFNLRTHDMTNEFKGFLFPNPPPSSQALPCATQRGFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLQ5</accession>
    <name>A0A2T6ZLQ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_252086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLQ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="19319" checksum="E324F1E5489E5D66" modified="2018-07-18" version="1">MKVPVWLRDLFKRELLVLLRCSEWRLVLYSKFLAGVRMPPNRLRVKTGMDRIWDRVVVLYLDVFYICTLYCCCCADKEGRTVEYALRLTSILIFGFIGFSFFLKVCFRRRFTAPMSSSPSHTVKTSANRTAYCVVETSLLWGRERKICDKRRAARPRRASVALVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM16</accession>
    <name>A0A2T6ZM16_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1129643</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000185">
        <property type="protein sequence ID" value="PUU76531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM16"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM16"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015575363" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="499" mass="54673" checksum="4E7E3AA7188EDF4E" modified="2018-07-18" version="1">MTLQKIVKTLAVLGALYGVSVAALPAANCCSLLEAVLPVNILSIGTSNYTTVNNDYWSSSAVLSPSCIFSPTSPQEVSQAVKLFTDNQCKFAVRGGGHSSVPGAANTNDGILIVTEGLNEQSLTNENSVWLGAGLTWGEVYGYLGPYHKSVVAGRYYPVGTGLLLGAGLSFFGNEYGLAIDNVKTYEVVLYNGTIIHANSTSHPDLHRALKGGGDNFGVITRYELITLDTPDWIWGGMVYYNQSQLSQVEDVLYDYHVDIAVNDVKTHVLPQFGFNGTTNETLNFSPIFYNGALNSTPAALQPWVDAQPYKNTMRPTQVVDLATEFDAGFGYGLVQVQRTFTVYADKQFFRDVWYQFQVWLQGYKQIPGFYGLHCNMPVTPNAVQQGVLKGGNVLGMEGAGNRTLSILYFGLTFNNLSDTDAVFPAFATFVESMMSLAEQQNVRHPYIMWSYAGHDEKVIEAYGEENNNFLRRVKQDYDPVGTFTNLVSGGFKLPAPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMQ3</accession>
    <name>A0A2T6ZMQ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMQ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMQ3"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="47"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="494" mass="55244" checksum="37E2F52312CCB952" modified="2018-07-18" version="1">MADLEEWRDIEEVAHVIAEDRANERIGQGKPEVLAPGQRVDDATHIIVIDTSFILAHLSLVNDLVLSYMEWGCVVVLPWATIKELDGLKKSNRITSISSQFGGHHVDISMLARAANRWAFQVLSKPEPGVWGQTREEVLDEKFNHGDMAILDCARFFYDQGYDTYLLTNDFNLSVNAIIYKIKAFMYEKGQSSQSLLKKIYGRSQRPRHLPKPKGFSTQAIESKAEQRLEKRVELRSELMNEQKVDSGLVQDPQADAIAGILPPNLIPGCFIPPMATQSHASNKASSNGSLSSSPRTFRAQQGLVGTGMAESIHAPRGREVRDTGHSRSYVRSTMLAIAAVVSAKHLSALLLEIQADALPSFRAAMKYHVLRCFGDEADYLEIHPEDQIRSLYDLESFMLKHSCAVFAEFIPKSTHRQLLSRYFSGTLSKLERFSRAPVEASNRPSVSEVLDFINDLDSLWQMTGAGIPQLAGCVWPVHVWRHKVNNDLGWSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMQ4</accession>
    <name>A0A2T6ZMQ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_989412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMQ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMQ4"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="66"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="253" mass="27698" checksum="748E4DF8A1275507" modified="2018-07-18" version="1">MDPLPNNMDEVLPGLFLGNLAAAESLAILKTYSITHVLSLTHSLPVVPEEAGVIHRHVPILDVPTQNILSVIDTCLDFITEALCGEGNNILVHCYLGKSRSGGVVVAYVMKKQNIPLALAHTFVKSKRPLVHPNRAFRSQLELWGTSGYDSTILDDYEIVDFGFGDELPVVHKKRSSKSSSKRHDRDGTADKASVLDSQALICELGAAAGEEVRVREGWGIVHMDKVTMARFERCLDEAGIVREDTGRPCWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMU2</accession>
    <name>A0A2T6ZMU2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1087597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMU2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6033" checksum="044051E40F348F16" modified="2018-07-18" version="1">MILYHTCFSNCISLPFSPPRPAISMSATSFGAPLPTLLQPLVERKKKTCEEGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN38</accession>
    <name>A0A2T6ZN38_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1129096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN38"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN38"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015660">
        <property type="entry name" value="MASH1/Ascl1a-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935:SF106">
        <property type="entry name" value="ACHAETE-SCUTE COMPLEX PROTEIN T5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13935">
        <property type="entry name" value="ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="568"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="680" mass="71673" checksum="AEDC83C7FBDD0DE2" modified="2018-07-18" version="1">MNNDGTSLWSHHHQVSPTSGGSGGNATEDFSSLFDFNNIQLSPFDTTGVQDDHSAMDPDFTNADELQTNGHSNDVDGPLDATGLLNSEDMLDMQFHDLHSLQTPQQQHSHHHHHHQQHQQQQHHAMLARQHMMQQSGMIPPTPSSIDLQTGLPHGPCSHMGSQSDIMMDRYNGLRDEQMIFTPLVSPAVTPLDTNFVHQVPEFAIPGYFSPLTSPALDAHPHRTHMPNPHMMRTHSQSTSPIDPVDSPNINKRGSTGRRKSTTSRNPARVVRESPSMKAQRKKLPAPLAVTPELANALSKQPLTPTTARQSASQCRGREQTGFQSSRDASSNESVSPEPLPEVLMAPPPPRNGNSRSPQNGRSDDGSSTSTTPGAPATPASLMKLTKTNLPTEDIPPIAMETSDFLNGDVERVMADAPPVSRNDSEAGGGGASAMMASPRLGGDDQPTPTIGASGAPSLKPVPSSSGSVSSGSRHESPINIQTPSSVLNKQKVSKSGASGRGGKRGSVSSSPGLQPKISPSIKPLLPSGMTPEASALLLKSNYQNIVEGTHKQLGLSYPADLSTNLTSKRTSHKIAEQGRRNRINNALTEIASLLPQKSTPGGGSNSDGGGGERQSSTGGGGGGGGGGGGGNASTGQASKASTVEMAIDYIKQLKKELEDTKGKLADAERKLGEKTGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNB7</accession>
    <name>A0A2T6ZNB7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_988508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZNB7"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1643"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="173"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="450"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="662"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="818"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="922"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1172"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1339"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1487"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1573"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="237"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="249"/>
            <end position="260"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
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            <begin position="266"/>
            <end position="277"/>
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    </feature>
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            <begin position="1349"/>
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        <location>
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    </feature>
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        <location>
            <begin position="1442"/>
            <end position="1451"/>
        </location>
    </feature>
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        <location>
            <begin position="1509"/>
            <end position="1518"/>
        </location>
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        <location>
            <begin position="1523"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1672"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1935" mass="207438" checksum="CB350497642FD8F8" modified="2018-07-18" version="1">MGSRQRSASALSQHNAIHCSTPSPGGMGGGSGNHTLHDSVDSVVLNAAGVPTFHGNSLPIPTTFGTGSAYPTITPNRPRAHTSADSSPSNAGAAAFGGLQPRQPSRNSMMQGHLGGMGPRHVSTSVLDNGSRVRVDGNGGVGGVGGAGGGGVAGNGFPVGSPPIQNGMVIPPPPPPPPPAKDAGYVPHSSVGRSHGREGMMNYHYTSHHHHPQQQQYGAYTPHQSSASSSTASLPQPQLPPLPPVPHQNALTNGNNNSIYTPHLHAYSHSHAHHPPHRPTEAPMYRQQSTQSSESIASSFTRTESNADSEYMTPATATSSGSVLAPVGNRSVSNGITRSSHVSHSHSQQSPLVSNAAGPLSPDVATVWTLDNVVAYLNRHEFSEEWQQAFRNLNIHGAGFLEMGQHNSASLLQIVLPEVLRICGPNADPVKEKLASRSIKKMVREILKLSQEVPNTPPPAGHNPPENGESPAKMGGTSQRSPAQARFPTQRGATFPTHSVYPDGSHNASEPFLPLGGSENSLQHRAGTSEPRSRSEFSKGALASTDQISRHSPSNSEASIQNPTDGHAFGKQALSSSPRNSPHLGYQSVSRHEPISTRHGKSDSQGSVASGTVNHRPGDGKGKEKALLVLGITSNERLGARQDYDGKSSSSGFVGRFRKKFRRETSDDDNDDGSPTAPGAPTLPYTIPENNASDSSLDRASVSSVDATRVKGSKPRSAPGGGTPKSKPVYVFATRDGKVWVSIDVTSLEKGGEIRREICRHLGINDYDAAAIHLTEVGQEPNDETLTDQMLKLSCQTRGDSIASLKFFVQPVPTSAFDMPIEDSAGQSSSGTPPHQSYASDPPNRLAHAGPKPQPLQLDRAQKQLNRRSSSPHLLIPSGDSTLKQSDITGSAATLPDTGTNGLGNQPRDDLDDLRERLALLRRHQDQGPKINVIPTPSLGPTPPGPHSSVQPSPNDPIPEPGSAYPSYTGWENDYSESSSLKTLVRTTTNGSPNDNGLSPAVRKNELFFDEDPSPITTFATLTHGPPHKGSAGTNQLGAAAQVRRQGLESIAQQQQQQEQQTGWLKKKKDKETDTERPSAGFQKVQTVTRPGRVVDFDNPRPSPYEDVKMETLIPQRKPPPPPSNRSSIGSISRVGSDFGGRGLPADVGGRYAPAARRVSIDRAAVAMEKAPEMSERTWRKGVSPLHEDRQSPVTGIGSSLISAGILSAQITRTPIPGMPRESVSAPSLPLYNQQTTPHQQQQQHYQQQGQQTQESPRPRAMATVDFGHSGTSSPQSEYETGPEKLTLQIPAAPLPRPSSPEISPGDRDVPLGIRKSTLPAGAPIDIQGNDVQFLSQTMPTSAEPRVQEEEEEEGDEDSDEDDGLFAIPISSRGEKPKTEFPKTDERPTLTIATKNVTFKATPTTSATATGSNGAMNSPEFEQGDDKWLNSPASHNISTPGSAAASAHSPADYTRLGRRESFGKEDIWASRPPPEALIDHLDDFFPGLNLDQPIPDEVSMSPPPSPSPATENKPQSYQLADIPSESPSTSEPPGAMGPPPPPISKGKNAPTVVQRNLGRAQLGRMKSIREVARGAHENSKRFTQTNTAGLKSGDISRRKSTKMFGARLIEVTPTKRGAMLQAQQASPPVQQQSGIKRQATFRWFKGQLIGKGTYGRVYLGMNATTGEFLAVKQVEVSKGLSANDSDRQKEMIAALNQEIETMQHLDHVNIVQYLGCERKEMNMSIFLEYISGGSVGSCLRKHGPFEESVVRSLTRQTLSGLEYLHREGILHRDLKADNILLDIDGTCKISDFGISKKSDNIYGDDPGNSMQGSVFWMAPEVIRPEGQGYSAKIDIWSLGCVVLEMFAGRRPWSKEEAIGAIYKLGSERQAPPIPDDVASVISPSAIGFLADCHTIEPSERPTAATLLNEHEFCSLDTNFNFLDTGLYQKIRGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZND5</accession>
    <name>A0A2T6ZND5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1128906</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZND5"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="769"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="41"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1049"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU76998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1306" mass="142327" checksum="9EDD1347FCAE8E82" modified="2018-07-18" version="1">MLSGIIPSPICLFKKSSGLPLSFLYTRTSYRLYPRLLHSSQKSSESDALGSAAVAEDSEEPSYAASDSFRSFRKPDSLSKRKPETRWSVPPSNAHGSADNDMRNGPPSKWSNGGTLDSGGSTPGSAPIRRYVENRQSPYGPHPRWGNTGRGAPGGDLDSKFGSRSTKWSVRPAPKPAAAEGGAHDTQPPPSGPTRSWDSSRTEPGVLGHRNPNTSSGPHAPRLKWNDPPPQPSFEAKEEYQRVEQARDIPPFRISRGDRTTDGRGVHPTPKPAAAEGGAHVTQPPPSGLTRSWDSSGTEPGVLGHRNPNTLSGPHAPRTRWNDPSPQLPFEAKEEYQRGEQARNIPPFRISRGDRTTDGRGIHPTPKPAAAEGGAHDTQPLPSGPTRSWDSSGTELGVLGDRNPNTSSGPHVPRPRWNDPPPQLSFEAKEEYQRGEQARNIPPFRISRYSLTTDGRRSEVSNRFPSGGAQSSSPELTKQGSINHTREFEQVDPKSNIAVGKGNQPESPSVKTAHSGLGKSIATDRESQIYSTDAPKTPDDTRTFEDRSPEVLGGTEHSSPTHKMNHVIKEVSATYVPNEDGLSGLAKTKEGGTGQRNAQEEKAEKAEFIASDHAAEGLRTRPLTPAELEYERRQLAKARERSRRREFDTRESAILEEGQGPLTGKAAKKAKKAKKREKQVEAAPAMIPLYLPEYISVANLARAVKMRLDDFIVQMQNMGFEDVSYDHVMNAEVAGLIAMEYGYEPIADTSKEEDLFPRPPPEDKSVLQPRPPIVTIMGHVDHGKTTLLDWLRKSSIVATEHGGITQHIGAFSVTMPSGKVITFLDTPGHSAFLSMRERGANVTDIVILVVAADDSVKPQTIEAIKHAKAANVPIIVAVNKIDKEGSDIDGVKQDLAKNGVDIEDFGGDTQVVLVSGKTGQGMEELEEATVTLSEVLDMRAETDGPCEGWVLEAGTEKRGRVATVLVNRGTLRPGDIIVAGRTWARVRSLINEHGVGVEFAAPGTPVTVDGWRDQPLAGDSVIQAASEDKAKTVINFRMEKAERLRQAADMEAVNNQRRAQREKEAAEKEIRERALADNKDPDAAVAASEKLAAESRKKYEVVNFIVKGDVAGSVEAVVEAVSPLGNEEVGAKVIRSSFGAVTEFDIDHAAAAEGYVLCFNLSVEPEIIQYARNKGVSIMTHNVIYRLVDEVSSKLSERLAPLIKYSVKAEAEILQVFSINVRQRKTMPVAGSQVKNGNLYKHDKVRVLRDGEIIYDGEFESMKIFTKEATEVKKGSECGLGFKGWGNFQAGDMIQTYEILEEARTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNF7</accession>
    <name>A0A2T6ZNF7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lethal giant larvae like, C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1087192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU77021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNF7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNF7"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="4">
        <location>
            <begin position="520"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1005" mass="109649" checksum="14327608B9C9D371" modified="2018-07-18" version="1">MDFLRSKQAGIQHDFTGALAAPDLFVLDEVEKYGIESSISVLAYDPIQSLLVVGTNETATTPGKVYVFGQKRVQVTFTLTRKASVKFLKLCDSRIVIVDTKSELSVFDMTDPEAQPARYSPPGIVSAVLTDPSLDWVFMGLQNGEVVAYDLDRQLKSPFLVPNLWRERSPKARMLPIVSLALHPRDLGTLLIGYLEGCVVFSLKQNVPTLYLQFEIPPGAPGADPGRSMLNSVRRPRLCEALWHPTGTFICTTHEDSCLVIWDTRDGKVIQARTLQDTNVNIPCGPKPSMLSETEGTVIVRQPLLKVSWCSTDNPDDTSILVAGGNLSTMPNKGLTLLDLGPTPNMLTSSVQFVSDHFASPRRQRILPTPADVDVVDFCLLPRTSPHYAGGHDPVAVIALLASGELATLSFPDGHPISPALVFHPSLSLVHPRVTTANLSPINRQRWLGMTENRDRPKEVIIGGAGHVKPLRRYENRTVLQTAHLDGTVRIWDLGLADEIENEKIMEVDLGQVLERGVDLKIERVAMAGSTGELAVGMETGEVVLFRWGKNKGYGRTSEDEALQAMSRSELGSAAGAIRDAKLKTNPTLKEGLLPLCVLEQHCGSVLHLACSDVGFVAIAYQTGHVSVVDLRGPTIIFHQSLTSLTKEAKRSSFRKSHDKPVEGEKATCLEFGVLTLEGDEFSSIALFVGTSHGKIATFNLLPQGPSFVCNFVNVTYMEGPVIKIIPLNSDSGKRAYATQQAVANLRDGIKVPGALLGVTKSGSRIFRPPTAKGAHRGWEDFDCLSANVVELETHGVCLSCVMSNGVVKSYSIPGLKEISEVKIGQWFEKDRLAEIIVTGAGYIFGWTSEAECLLLHMWGKGDSCADTPRDTLYNPNTPVPARPTISNFQWISGTQYVTAEDVDLLIGGPERPMSRKMIEQMRAEKRQAAIDARTGGAAAGASNQDGVFANMAKQIQERTERLNIMGDSMDRLGESSANFAEDVNKYVNQQKRKALLGGLTGKWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNI4</accession>
    <name>A0A2T6ZNI4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1087042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNI4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNI4"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="9">
        <location>
            <begin position="139"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="8">
        <location>
            <begin position="834"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="887"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="892"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="939"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1056"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1083" mass="117689" checksum="D5204939EC32F61C" modified="2018-07-18" version="1">MPGLTSAFGLIGLLDEPDQQLKCYALQNLDKLVDQFWAEIADSVSKIEVLYEDDQFSERNLAALVASKVYYHLGEYDESMMFALGAGDLFDITAKSEYVETIISKCIDKYIVINSHNDSLSSATGSSNIDDPSFAVSGTKKDAQSVVPQKADPRLQDIVERMFRKCYETEDYKPAIGIAIEARRLDVVEEGINLASRRSKDKKGKEKSSEEEKDGGVELMEYVLEISMNVVQEIGLREKLLRLLVNLFLSQGSPDYFSISKCVIHLNDTSLAAKILQELVQKEDSKSLLVAYQIAFDLDSSAAQEFLQKVANDLPGPEADESDALSTAATAGGDTMATDTEDDENTKLLGGNASSAGSISGKTSKYYRSIRQILRGTKSIEIALEFLFRNNHTDMSILNKIKDSLEARNSIFHTAVTFSNAFMNAGTTSDGFFRANLEWLSKAVNWSKFTATAALGVIHRGNLSQGLKLLEPYLPQEGVSTGSPYSQGGSLYALGLIYANHGTDVLDFLRKQFKGTSDEMVQHGGALGLGVAGMATGNQGIYDDLKEVLWSDSAIAGEAVGLAMGLVMLGTGSSASLEDMVQYAHDTQHEKIIRGLAIGMALIMFGKQEAADDLINTLLDDPDPTLRYGGIMTIAMAYCGTGSNKAIRQLLHVAVSDVNDDVRRVSVMSLGFILFRKPNAVPRMVELLSESYNPHVRYGASLALGISCAGTGLDEAIDLLEPMIKDPTDFVRQGALISMAMILVQQNDQMNPKVASLRKTFEGMVGEKHEDAMAKFGAALALGIIDAGGRNVTIGLQTQTGSLNLPAIVGMAVFTQYWYWFPLTHFLSLSFMPTGLIGLDDELNVPDFKFWSNTRPSLFDYPPKVEESTEKAPEKIATAVLSTTVKARQRAKRSEKEKAAKEAAAKGEDAMETDPVSTPVTPGPIAEGDDKMDLEDDSAERKEGEGEGEKREEGEKKKRAEKEKVGYELGNMSRVLPEQLKYISFTSDGRYEPVKKPTGGILLLLDRTPSEPVKLMELKARKATAPTTTGPGHTVGSANDGPGTGGAAAAVNVLNTEDDEGDEDAPPPDDFEYITDGETEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNV6</accession>
    <name>A0A2T6ZNV6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1086745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNV6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNV6"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="568" mass="61745" checksum="C35EDA657822B992" modified="2018-07-18" version="1">MAANNKTSGGNAAFHNFNNQFAHISDPNERRRLALAEIDKAPFGWYHVRAIVVAGVGFFTDSYDIFAINLVTGMLGLVYWKSGKIPEHSDTAIKVSTSGGTVIGQLAFGWLADVVGRKKMYGLELLIIIVATLAQALTSESYSTHIVGLLIFWRVIMGIGIGGDYPLSSIITSEFATTKWRGAMMGSVFAMQGIGQLTAALVALIVTVAFKSQTHPAAKPSACNDACRTAVDRMWRIVIGFGAVPACVALYYRLTIPETPRYTFDVARDVEKGRSDAGAYLAGQSSGEIDEIRRVEEMQRSAELDVPKASWKDFWSVFLQWRYGKILLGTAGSWFLLDVAFYGLGLNNSIILAEIGYAAKDNVYLRLYNNAVGNLILVCAGAIPGYWVTVATVDLVGRKPIQLMGFTLLTILFIIIGFAFHKLSSNALLGLYILCQFFFNFGPNTTTFLVPGECFPTRYRSTSHGISAASGKVGAIIAQVLIGPLRTRGATASNASPWLNHVMQIFAVFMFFGIFTTLLIPETKRKTLEELTAELYGEGIAGEEKALAAATGTTDVAVEDYGKRVEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP64</accession>
    <name>A0A2T6ZP64_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP64"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="32413" checksum="AD5C4B40B4CD1318" modified="2018-07-18" version="1">MPPIPPFSNPGIPPFRHHLTAIIINTTHHSLPHLIRVPPLITLYALLNFTMKTEILGMLRNHTGALIGLVGSGGFTYAYRLFDRGQREKERREQKTAINEKVKRFGVYEEAIRQEGIKERRHREERIIGKDKESVMAELDKALTPFGRTTLTSIPATGGISRHVCPVAQIATASIGTIGVSRHKIPPYILLCESLATNLMSNSSPSSAKVRPHPLRHLLDLLMLSKISLAFILKIVIECRNYPAVIVNLSGSNRENILGRWPRVAMCHTMVGFYRNLIAGVNKRSNWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP81</accession>
    <name>A0A2T6ZP81_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_987380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP81"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="148" mass="16359" checksum="90C01E8E35E520AE" modified="2018-07-18" version="1">MLLPPPDRRELTPALPSATQTETDPSVQTSIRPVRIPDGTLRLRGGPVENRRVRWDADVIDNEGMGKKKSKVCCIYRRPRAYDESSSDESDSSSDEDSEDEGHGHSHSKNCGHGPKRSAKGKSRDGKRAPSPNAYEKMPKPARKKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPF4</accession>
    <name>A0A2T6ZPF4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPF4"/>
    <dbReference type="OrthoDB" id="10487895at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="409" mass="45260" checksum="62E98541017DBB30" modified="2018-07-18" version="1">MPTVADEEQKGLKHCLCELALATPKELPDTSYQHALEFRKWLLQFRDLASASTIAPETSSSSYITSHSGPYKKALTSLQKFHPKLDTSVACLSPLQEKKSQRKQLDLPPTLSKGNKGSISKPAGVQGIADRAEMEEPVDMEDTGSEESLSGNEGSEGYTKPPSKPRSKERIPPPVPLCEGQIYFSTRFHVKLRKPQQERLGAHSVGTKNKCRKSRPWVIVEVLGHGHARAICSTTREKKTWSGVTRETAGSFLPISPTESKFERPVVQLADDARNIFTGLSLLFLEIQQDIKVELLGDYIGSLTEEGLATLREQRKKWEKGGKVAPSEHYGKGEEGDDEDDENDDSGEEEGEEGVEDDDCRDVDDGWTLVTHQKRPHCTRGRGRRGNRGRGNCRGPPSHGHSNGGRRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPK2</accession>
    <name>A0A2T6ZPK2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1086299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPK2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPK2"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="189"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="60404" checksum="D3E0A0A61540391D" modified="2018-07-18" version="1">MHQPAEAISNIMPSSIVVLAASICNVFVEVSLFWQKKLWGWYTRKKPKEELLEKLATAKSYEEWETIATQLDGVLGNDLWRQNPTSKYYDYKLILDRLQSLSEAREEGDTLRLVNLLRSGLLRNLGNISNINLYNRSYAGSKRLIEDYISEVGICLEHIASLPPLTSLTSQSKLDFLHDTRQSFGRSTLVLQGGAIFGLYHLGVVKALHLRGLLPRIITGTAVGALIAALVGIHTEDELLRFLAGGGIDLSAFDTKKKEGSWKRKINRFLQYGYFLDIKVLEECVRANVGDLTFEEAYTRTKRILNITVSTAGKNEVPTLLNYVTAPNVLIWSAACASNATSTMYDRVELMCKDENGAIVPWAAQEIVWQPWTRVSYTDREAPTTRIAELFNVNHFIVSQARPYLAPFLTSDLHRHRRRGITLKLLRLLGLELRHRLSQLDLLGLLPFSVRRFLVDETIPGASITVVPHLKVMDFEQLLENPTSETLDYWILKGERSIWPAVELIRVRCEIELALDRLYQRIRNKPPGSDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPS4</accession>
    <name>A0A2T6ZPS4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000152">
        <property type="protein sequence ID" value="PUU77472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPS4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="12486" checksum="FBB96804500D645A" modified="2018-07-18" version="1">MPFFAKLKLKLKAAWAKISLPFVKKSTKKLGPPGYGQVPYIIRKCPICNIAIVPYRITVCYNLVGIGYYNLYTIRFGPEEEEEEEDWGGMRKAWERLRGWLLGRSNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQE2</accession>
    <name>A0A2T6ZQE2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQE2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQE2"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="1">
        <location>
            <begin position="61"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18726" checksum="CE5E4DCF10A9BBED" modified="2018-07-18" version="1">MTRWGDPHFMYHSTIAQIAAKTVLRISENVLLSYNVSKFSTALQSMLSDLKGEITTTGIALNVSPLEAAIIRFTTAARDLMAIEEALKPGEWGGEQEAIVNERLGKFERGFIGDGLPGRVFYKHLIYAPGVETGYAPTTLTEVVRVGNVEEATMYVGITAAAIDEVAKLFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQL7</accession>
    <name>A0A2T6ZQL7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_960243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000141">
        <property type="protein sequence ID" value="PUU77773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQL7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQL7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11499" checksum="B0CA0E7B12199031" modified="2018-07-18" version="1" fragment="single">VRTLLSDSKVEVNAKGHDDQTPLHVAAIEGHLECVNALLEDTRVEVNTGDGKGITPLSHAAKMGHKEIVQLFLSDSRVDVSKVDEDGNTPLHMAAHSGNTDLLQLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQW2</accession>
    <name>A0A2T6ZQW2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1065504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000137">
        <property type="protein sequence ID" value="PUU77871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQW2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQW2"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="300"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="613" mass="67222" checksum="584EC5E058399C28" modified="2018-07-18" version="1">MESSTAPTILDDIINEDYSILDSVHKSASTSDLTLGTDPLANQADKGQFSKSRQDQHASSIVQPQPPFLDPALSRHYDATNAHPTTTARNQCRFGSSPADTTLSAHTHYVPYLLPPCFPTSALRKTLGPQEDQCHSSLAAASSSSARTRYAPYALPPAHYTTSPPSKTAFPLGGSRFTSSVTAVSLSARARFPPYAFPAACYPALPPGKTAVPQSEGHSSSSVAAFSLLTPDLYVLSTLYPTRYSTPPRCKTTVPQGDGHFDSLPATLSLPPSPPPPSPLAPEPTTVGTHCAPVREPSAWRLNYILGTGACGTVFLENVHMPGMKSPELWAVKRIPRALPNFTFKRFQAEINNLQALAIYEWFIKFHSTYQDTHYMYIAMEYIPMGDMSQSFADGYRWNEGDTKVVIKQLLHGLAVMHKAGITHRDLKPENIFLHLPENQTPVLRVKIGDFGTSKRIPPTNASTYLKTTTGTQGYMAPEVHDTSKLKTNRVDIWSLGCILYRMFAGTLLFIDSFEVLKYSWTAPSSPLALDDIGFSIPCVSFLRDILRPNPKDRPSAEDCLKKAWIMSEAPELEYSIGNDLYTRLANISHRSPNVDSLPDIVANRAVESSSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRH2</accession>
    <name>A0A2T6ZRH2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fms-interacting protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1101581</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRH2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRH2"/>
    <dbReference type="OrthoDB" id="20582at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019163">
        <property type="entry name" value="THO_Thoc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375">
        <property type="entry name" value="FMS INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13375:SF3">
        <property type="entry name" value="THO COMPLEX SUBUNIT 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09766">
        <property type="entry name" value="FmiP_Thoc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="220" mass="25446" checksum="F3E1282723C217BB" modified="2018-07-18" version="1">MTIQGIITDPALRECLAVADRTRLLCHQILTTIESATGAELPEDERIERSRTQKQLNALLTQIKGLHRAAIMSAREAKEVTGEVRREVDRLHLQLQNLYYEQRHLRGEITACREFPHQYTSLPLVSEEEFLTLNPEHQGDDTHNLMIARLNNEKAVREELEKQRKELLAKKQALIAENKKRKDDLASLDEQLKKFIIEAYSKYFPEGVLAIHLNASFYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS32</accession>
    <name>A0A2T6ZS32_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS32"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS32"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="331" mass="36914" checksum="D89386E59A2EF789" modified="2018-07-18" version="1">MATLPAENMGAPRTPSPPPQPLGYPPPGPNLGLSQPSSLASAHLSPQPSALHDMNYYLTEGLQSVEHQQFRDNRSFIRAIDSQVKKLCSGKAGQYLVFAPVTQDQFVAIERMRQNHHKGIRFHYFNREETLIVKIFAGPVQALVGCGFGTRLDVKIGGMGLVSYIFRMDTATYKGNGSQKQANIAWKPWSPDHGVADWPTVVVECGVSQSRDRLEVDANWWFENSDGQVKIVFLISFSEEKKEIHLQQWELVTAPDSHVSQAEPTATSTAPTIVCELDLTPGVPNRESLMLNFERVFLRPPAQGEGHREGDITFSPEELEEYAIHVWNHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSC2</accession>
    <name>A0A2T6ZSC2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3824 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSC2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSC2"/>
    <dbReference type="OrthoDB" id="5423899at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65099" checksum="358E9D77F76E3B97" modified="2018-07-18" version="1">MPVLLDDEMLIPPSMRRPKRYYATNPYDDPRVETTIIESPSMASATTIELPSHRSLTPPRSPIVIHEDHYVTVPTEIERSRGREYVIHPAGRSAVYHERIGGGGFGGEMDVNYSHGHGYGRGRRYYRASSVGPVSDYDSYSDDYYLEDGTHHGIGHHRHGSPPSHHDRHSHRTKHLLEGGAGLVGAHKLHKHKEHRERPHRRSSTDDHKGHKGRHLAEAGGLALGAKKLMRHRSHSRPGRHPSPEGHHRARHLAEAGVATAGLKHALNHRRSRSHSPRRRLSSDSERYPGWNDDDHKAHRRAKHLAEAGLGIAAAGAAKELYDHRKHHRSSSVSSSDGERNHNGRHIAAAALGATAAGLAHHKHAHHRRRSSSVSSYSSGSDDENKHRGRNIAGAAIGTAATGLAAKALYDRRRRKNRSRSSSASSSSPGRDKHRHQHRLEKAALGAAATAGLKHHHDRRSRSRSRSSSRERRNHASGLKKAGYTMAGALAEKHHREQRNRGRSLSAEGRRHDGHHNGHHDGHHITHGHLKPGQGFVESESIHSSPGRTGTRSRRGSHGGGNMGEAVAYKLGEAVAEGLSGRRGSGGTGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSC6</accession>
    <name>A0A2T6ZSC6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_983426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSC6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSC6"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51219" checksum="C8A7FDB90C0BEFD4" modified="2018-07-18" version="1">MIADWTKGQWIDCNAEFVDKTPIEYILTVPAVWSDKSKSDTLKCAVDAGFCSAGEVSLITEPEAAAVYTFTTLPEYSIKEGDIFLTCDAGGGTVDLITYRVLGTKPVLKVEEATLGTGGLCGSVYLNRRFEDFVTKKIGKYLDALPRVAYVEGMTEIHRAFNEEVKTDFGHGLEDEKEYTIEVPAGIPDNEEAGVRDGCLVIRQKDLEEVFDPVIDRIVMLIAEQIEAVAELPGKNKVSAILLVGGFGSSEYLRRKIEGNPIWEGTDVIQPVNAWSAVVRGALLRGLQGDIVSTRKIRNFYGIEYRQTWDPEIHEVGDFAHEAAKHKLWSEIEQRYFCAQRMNWYVKRGDEFSSSKVVNFPFYRAITDTKQLRFTEELITYTSSGDAPDFMDSQCSVLAGIEVDLTSFPLETWKTVQGPAGSYYKVNYALEMSFEAAISFKVVCKGTVVGEIVADYDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSX2</accession>
    <name>A0A2T6ZSX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_61668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000115">
        <property type="protein sequence ID" value="PUU78576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSX2"/>
    <dbReference type="OrthoDB" id="5358929at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="36361" checksum="799A4529AD9C47BB" modified="2018-07-18" version="1">MTPGLRSRGGETQAPQLPECGHDRSCLDFGTDRDIKCRRCWDNREILIQRLIEPFEHALGSFGLDAAVTGDAVVSSPTASTTPAERTTERRRSLRRRAGSKRTRSESRGSTPIPKAQEAKEKPADGGYSLRSANRTLSDPEEEECIRVQDLSLMRSRSQDSGGPVGKSIKPTSSTAGLKEGGIKWWENRGPGAHWKSVKAIGKGNERSPSVASNSALRTKAATQPVKKSQQQTLFSFFTPRPAGDDRAPTPPSHTGSPDILPPTISPTSSSQKKPAVIEALKVDLVPKAKEKRLPEKVRKQARPGTRRSMRDVKKDTINYKEDSDSDVDLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSZ0</accession>
    <name>A0A2T6ZSZ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSZ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSZ0"/>
    <dbReference type="OrthoDB" id="1937642at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="375" mass="42529" checksum="769FC34F3E32A3CD" modified="2018-07-18" version="1">MAEQLRQQWQNPRDIMSVLMILGSEAVHKTIAQMAGGPFVPTPFSFGWVGYSFAALGNAVGSGRLLPEPDWPTFVINLKNGYIRENCSWVLGRLLRDFEMREKNKDYALKIVVYNLDLNDVGGRPARWWWWWTKRDREVYIKPKRDWVWWSGAVTIVLQLGISITPWLTEGDWTIFMTSTAATLLAIAGASWPNMSAEKWAGRRSNKCVALTRGNGARYAMILKYRDGEKGLDLEDLATAMTTPSLWDRIVTGTLAIAWALLLFNICGLQNKTWYILGVGVIGMLQNQLVSGVQRDPASSGIPLTKVEEIREFKVMNALKKVETHYPGFGASLLPTFFPGELWPDEVSWWEERKMELKTIREAEKQAKLAQKAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUB2</accession>
    <name>A0A2T6ZUB2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1064554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUB2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUB2"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="467" mass="49654" checksum="698564681A216AE5" modified="2018-07-18" version="1">MSLASKTEGQKIFEKLKSNRANKVCFDCGSKNPTWSSVPFGIYLCLDCSAHHRNLGVHISFVRSTVLDQWQWDQLRLMKVGGNESATKYFQSHGGSAALASKDPKVKYESSTATKYKEELKKRAAADALLYPGEVVVEGGEEAAVPAEAEEEDFFSSWDKPSIKRPTPPPSRTATPPVVGRAGTPSNGSGIARTKSPLASSASDPPPAVSRTTTSSALRTKAGAASASGTRRAGVLGAKKGQKLGAKKATGGDVIDFDEAEKKAKEEAERIAKLGYDPEAEQPAKKETKGNVFSPTPVTPSSPTHSRQSSDVERLGLSMNRLGFGQVAGAAAAGGPAKKMGGFGSVGSSSKVEEDDQKYAREKFGTQKAISSDEFFGRNTYDPQAASEARTRLQGFEGATAISSNQYFGRDDEEHDADAAGYSELELTARDFARRFTGTAGEDLENAAQVLGQAAAKASEIVGRYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVA8</accession>
    <name>A0A2T6ZVA8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1107682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVA8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVA8"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="256"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="670" mass="75129" checksum="50C75FCFE9AA431D" modified="2018-07-18" version="1">MPNRRPLSSHDGRPTTPMTPMAPMTPTVVKDDMNFQELCETFKNYFVEYIDTPQNMSTLKLSPVMTRLCNQLSERGHNPATVAALLWCKVHFDAEEDNSGGHGLGGSRGLACEFVASDLLTFLSGNEALEYLCYELPLVRNEDYDGNNAARDETAGLLGRRDSRNISSSDLEADSIASYAGLNTLEIAILADAKKFLSHRPVERVINGIWEGRISFWKTLDVDGSKKPHFYNKRKADPFCRLRVPKYQKAFEAFFFAVFLALYYGVLIQRDPYHITGLEAALIVFFVAFAVDEISSMRDAGTAFYTADFWSLWDVCIIIIGIAFLIWRIVGIVKDNDEIVDTAFDILSLEALLLIPRVCSLLSMNPYFGVLIPCLKQMTKDFLKFVILVVILYLGFLTTFSLLARESFTLSEMSWMLIKVFFGSSSVGFDAMREISPVLGPPLMLIFVTVTNILLITSLISLLSNSLTNMMNNAREEYLFRFSITVMEAATSNRLVVFYPPMNLLSLILLRPLRLVLSASRMRKWRIALLKFSHFPFVAAIMAYESLWPDNQTRYTTAAWGPGAGSKRMSMREGLKSFGRRPDRLQEWSGRLGGSRLGFGGAGSQAGPQAGPALLSSASSMRMDFDGESASNLKAYANQIDEHGQELHRMRTTIEQLSRKLDEVLSQQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVJ5</accession>
    <name>A0A2T6ZVJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1081613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVJ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVJ5"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="448"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="524"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="603"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="670" mass="74944" checksum="8DF52FBD24691FE1" modified="2018-07-18" version="1">MPPASSNLEAPPSDTALVRKRGISSGRVPTNPKMEEFLKSWRQDALNKHQYDAAIYIGDKLLALTGDPKDAFWLAQVHFSTGHYSRAQTFLTRNDLISRSTSCRYLAALCLIKQSKYDEALNILGDKDPTHLFSGSASATNGRRRAAAGGRSSKDREEQVGNVKFEAAMCYLRGLVYAKQNSFDKAKECYKHAVLIDVKCFEAFDQLMRNALMSPDEEWTFLESLDFESLGADGEEPGEQAEFVKMLYTTRLSKYKNPAYFHKATELLSETYNLAQNADMILSKAELLFTQCKFKECLALCKKVIDDDNYNFSIYPLYLACLHELDEKNTLFLISHDMADNYPEEPVTWLSVGVYYLTIGKIAESRRFFSKASMMDPHFGPAWIGFAHTFAAEGEHDQAISAYSTAARLFQGTHLPQLFLGMQHLQLNNITLADEYLNNAFTLCKSDPLLLNELGVVFYHKDHLKESVQLFTKALDIAEEIESDPKAWIATRANLAHAYRRLEFFDKALEQFFIVKRTGEGKDANVYSAIGLCQMQLGRPWEAVVSLHEALAISPQDPIATELLEKALQENSSSNLLFQSSVMSADGEIIIQDDEEVEAIINQRLKGKSKSRQRHGNDGESSGRALRTTNRSAGRSAPTAGDAGGGGGRRRLGDVTSNYQEGMEISDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVP0</accession>
    <name>A0A2T6ZVP0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1100739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVP0"/>
    <dbReference type="OrthoDB" id="5292402at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015457390" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30190" checksum="22C0A02CBEE7FA83" modified="2018-07-18" version="1">MKFITAIILTVLLQITTTTVAAPAGPSSEILMPRELKLPTEYRKNCRTTQLGGLQDATNILRAGFADVLTMVRDAMKVSPTAYHNWFQNWLPIADYHLFLKLCASVGEYALPQSEFGTIFVDCESPTPACDRLKEPDHTTSRIAVTNPENNFLYACFKMFDPAHAEFRRPLSALLACPNKSDGVPSISNWQVLGTTLVREIAHTSALIRRMGPPYLFTDNQLHAKIDRLGWMVTHAYFQKKCGYAIPIGNDRWEYKPDLANIEEVFHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWU0</accession>
    <name>A0A2T6ZWU0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1080496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWU0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="9567" checksum="7C25A1E7D4369724" modified="2018-07-18" version="1">MLPRCPLYYSTKIYLSRYDTMAMSHEIKVGVRAILQALPKTIKKVFIVFTIPEDRVDKEGGWAMVADMPIELRRIRGMFKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX37</accession>
    <name>A0A2T6ZX37_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1124225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX37"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX37"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="336" mass="36850" checksum="1CBE2975F2640BBE" modified="2018-07-18" version="1">MDDPISAQEQKTYQSLVGSLIYFATTTPPNLRFTIAYLSKYNAAKSGHGEVAKILLESKEVNPDKPNQFGQTPLSRAALAGYGEVVKILLKQEKVSHNQRDEDEKLLSFMPLRLSKYREIPPSHAAECGSEGVMKILLSREEVNPNRPDRSGGTPLMRAAESGHEGVVKILLEREEVNPDELDNHGKTPLSHAATNGTEGITKIPLGRKEVNPGKPDNGGKTPLSCAASRGNEGVAKILLGREEVNPDKPDNSSQTPLSCAASGGHERAVRMLLGWEEVNPDNRGNDGKTPLLFAAWYGHEEVVKLLLSVKRSTLISEIITAKHRSRKRPRMDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX81</accession>
    <name>A0A2T6ZX81_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1080315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX81"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="407" mass="43471" checksum="CCB8C7255A171C93" modified="2018-07-18" version="1">MFLRAPRRFFASTAAVERRPFRNDFTHCVIGGGVVGLAVARQLSKRPGTSTLLLERHQAIGTETSSRNSEVIHAGLYYPPNSHKTTLCKAGNALLYALCEKHHIPYRRTGKWILAQDPDQLESLERLHAHACALSIPTKWLTSQQARSREPAVRAEAGVLESPLTGIVDSHALMTFLHGDFESAGGDFAKGARVVDVQTIGHGGDMGYRVTVDGDGQVGGGGGGGEFSISTDVLVNAAGLSAIDISNMLLRSHPERLLQAYFCKGTYFSYSASTPKVGTLLYPAPIKGFGGLGTHLTLDMAGRVRFGPDVEWVPDPNNLVPNKSRMAAAIVAIKTYLPGLQEAALAPDYCGIRPKLAPEGIGGVGQVDFVIREEEGYSGFVNLLGIESPGLTSSLAIAEMVDGILYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXC2</accession>
    <name>A0A2T6ZXC2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1045232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXC2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXC2"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="294" mass="32004" checksum="0485F540F7BE7D75" modified="2018-07-18" version="1">MPSRKLSGKPEELAAFIDKFDIFLFDCDGVLWQGKALLPRTVETLAHLRNLGKHLLFVTNNSTKSRATYQKTLQDFGIPCDVNEIFCSAYSSAIYISRVLQLPRDKKVYVIGESGIEEELAAEGITYIGDDGGDITPEDYDSFGPDEDVGVVLCGLDRAISYRKLARAYQYLRNPETVFLATNIDSTFPTHGKLFPGAGAISAPLICMTGRTPVSLGKPSQAMMDAIEGVLKFDKKRACMVGDRLDTDIRFGIEGGLGGTLAVLTGVSTEEEILEEGAAAVPDVYLDRLCDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY86</accession>
    <name>A0A2T6ZY86_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_974870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY86"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY86"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="591"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="692" mass="76367" checksum="390EEA8E8201DA28" modified="2018-07-18" version="1" fragment="single">MQATSPPINGSSAPSSVPAKAQTLPLQKRRRVTRACDECRRKKIKCDGKQPCTHCTVYSYECTYDQPSNRRRNPAPQYIEALETRLHRMEALLKVLLPDVDVNHPNFDLGKLLSQVQTNAATRAAGKDVTASSGRPPVVNGSATTSISAEKDSLLESMVEAAGRLDIDESGHMDFRGHSSGVAFLAHLNTQLSDLLGSDACGKALVKVRAAPFPNVFDTPGSAAGSPFDGQIPNTSMLPTKEVAKVLLDVCMDDACVLMRFVHRPTFDDVVNRIYEKDPNDFGDDENNHLPLLYLAFSVGCIFSSDLTGVGILDPVAEGTKYFNIGRRMIEITDCWDIPSIQCVIMMVLFLQSSARMSTCYSYLGIALSASVRMGLHRSLPEARFDPIERETRKRIFWTVRKMDTYVGALLGLPKGIADEDIDQEMPAEVDDEFITKDAILPQPDGVMPMILAANAHCNLLKIMAKMVKYIYPLKGVEASVTGKRSNYSVSSSKLGEIECDLQAWLEKLPMQLRPGGDTPKELQKVQYLLKMAFAHVQMMLYRPFLHYISRPKNEGCDERPYASAANCVNVSRKIVHTAGEMGRLGILNGAYWFTMYTCFFSVITLVYFVLENPEEITSLAVLRDAEMGRELLASMRDRSQAAKRCSVALAALFGNLPGNLRPGLEKANLAIKKKRARASSQTKASSEDPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYN7</accession>
    <name>A0A2T6ZYN7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartokinase</fullName>
            <ecNumber evidence="8">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_974502</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYN7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYN7"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="466"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="57389" checksum="B7E16E95EA806837" modified="2018-07-18" version="1">MTIEQPPSSPLSPFPTRTGPVHLQTNNPKFPWLVQKFGGTSVGKLPLGIVEVVNRKYLPTNRVAIVCSARSTESKELGTTNRLLRAAEEAIKAESTEWVDIIEGIQESHIAAAREVVKARAIFDEFRVEVERECRSLRGFLGAAQIINEISPRSKDVIIGTGEKLSCMFMTAVLRDRGVDAEYISLENILPPNHLPTYTANSKTLTPSFYKTLATLLEFRIRSLPAHKVPVITGFFSPVPGSLLTTIGRGYTDLCAALLSVSLKAQELQIWKEVDGIFTADPRKVPAARLVSFITPEEAAELTYYGSEVLHPLTMEQVVTVGIPVRILNVWKPYSSGTIICAKKPTKAAHPLTLTPPVSDGEDDDDDEYFEGEEKEKKLPTAVTMKKDIHLLTIHSNRKSLSHGFLASVFQTLDQHELAIDLISTSEVHVSLALLNTSPHAIAAAVEALEVYGSVDARGGLCIVSLVGRHMKHMVGVAGRMFTSLAEAGVNVEMISQGASEIGISCVVREEAAVGAVNILHAKLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ22</accession>
    <name>A0A2T6ZZ22_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1063259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ22"/>
    <dbReference type="OrthoDB" id="10562945at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015663378" evidence="2">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="218" mass="22589" checksum="2065D5740C46B801" modified="2018-07-18" version="1">MQINYYPLLLILPALSAHAAPPLPQQPQQSSTTVTPQTLSAPPLPPLSPTPLIPPPISGKPPTPPPQLQPPKQPQLLLKSLDGPEISSTLITTCEKPTSASPKNTDVQALSKHYQSPQVSSLPPLALAKDKRACVPLESVPASNAKIELCGQDVFVSYSDVGKVLDMLLVKCSRGEDGGVVDGSVNGGGGGGGVAWTAGMVSAIDDGRVLFSVRVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZP8</accession>
    <name>A0A2T6ZZP8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="9">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1122738</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZP8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZP8"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="12">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="11">
        <location>
            <begin position="163"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="13">
        <location>
            <begin position="486"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="362"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU80954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="648" mass="75266" checksum="2975CD51204F2385" modified="2018-07-18" version="1">MSQNAAELCVLLVRDIYGEVSSRVVSVLLELGRLSVTQLVDQLELDSKIVMETLAVLIQQHLVVHFSHLETGRKVVYYECEWIQVYELLRAGRIIRVVEERFGSNGALIVSNLLQLGHARVSDFLTAYGTSTKKSKATVNTNAPAIEDELSITSVDILKSVMADMMKERFLVQVQEHHMHIRTDTRNTLRAQLTSQLRKSQLSENKLGKEVDRQMKIKMQELADGDTSQHAGMKRKAAPASKPKSKKRQKVSIYDLIDQEEEEWEINENIVLRINYEKFLVLFRNAELVSLAESRHGKVSSRVYAEFLKRLEEKYFRCREPYSGDDDEEDDPKKRIKLSVLELSKTFSKDIDLENSIVAAPRPSKTKARKRSYSDGEDEDESRPNGYGKKVNRKNKRRKGNSGDDDDDDDDDDNDISDLEELYDDEEEGIDAENRRKKIRMELLKQHMQLLAEDSWKFVRLESNRGFGEWSVNYKELGKLMRHIELEKVVEETFGEMGLRLLRIIKDKGKLEEKQIASIALLKQKEIRSILTGLQENGYLHLQEVPKTSIPQISRTYFLWFHDPDRAIQSLITDTYKAMSRAIQRTNVERAKRSSLLEKWERSDVQANVEEYLTTSEKRELEIWLSREEKLLGQLMRLDRTMMILRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A020</accession>
    <name>A0A2T7A020_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_972910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A020"/>
    <dbReference type="OrthoDB" id="5397330at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="249" mass="27533" checksum="FB664A6089BAAF4A" modified="2018-07-18" version="1">MPVIRNPFRRNTTAPVNNRVDSFSEHQPTAHPDTGRLPASETDSGTDEVGRAHSTGAKSASAISIGKESQEEKNTYKLSVVNDSGVYLPPSPPDKKSFWRKSDNSPQTKAPEVEEPFVISRESFECYRRSFDISARSPVLDPSPGRVSFDSRPLVPRTSLDVRSPRLPIVAKNVEPVEEDKFEEIKLNDDARPKKRSIFSRFGTDHSPDATLAPASHGVRNGLFGKKEVPQGAVLESELKKIDIKKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A044</accession>
    <name>A0A2T7A044_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A044"/>
    <dbReference type="STRING" id="42251.A0A2T7A044"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015718402" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18920" checksum="250F9220C7AD07AE" modified="2018-07-18" version="1">MRLNLIAAISILSTLASGLGLPGLAPRSLVIHPETCVMNKEGFLGTSFPDPPCGVSRGNGKDTVTALLCFVVPPCNGQCTISFTDALTATGSRRLQLFTLDRCPTTGGDTWGSKPFRDKHIGTFLVSIPGPAAVVEDFGLTFPCPKTVTKYGFELQPVWDNDSVTWDNSKGGLIITCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A074</accession>
    <name>A0A2T7A074_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1099881</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A074"/>
    <dbReference type="STRING" id="42251.A0A2T7A074"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="378" mass="40581" checksum="E744C0C0ECEC5EF7" modified="2018-07-18" version="1">MAVDNRQRHHSLHHSTFGGFQPPTLGSVQFTNPWTSASPQSHLIASSIPDVGGLGSLVKPDLRSSSVATSYQTIPTTAGIPTSNPNRNMSSSTLLSHHNDFMKGDLLSFSANSAFGGDISMSGSSAPSPTAVASYSGVPSFAPTLDFSTHHSRTSYPLSNNDRRMSQPAMSNTMFLGSPVEPPRQRQNSLMEWTSSSRPLAQPPRSTDHHQFSDTLDSARGMVAMSQASRQPRGRTDGSHNFYPSHSANSSISSTGSYNGYYGGGSVDSSATDYSDSAGFTPEAPRPTLPRPGPGIHSVPVQGALMTTFSSKITSSTQKKHKCKVCDKRFTRPSSLQTHTYSHTGEKPFACEVDGCGRKFSVVSNLRRHKKVHSTKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0D5</accession>
    <name>A0A2T7A0D5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1077754</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0D5"/>
    <dbReference type="STRING" id="42251.A0A2T7A0D5"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="13">
        <location>
            <begin position="360"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="12">
        <location>
            <begin position="605"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="12">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU81155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="715" mass="80686" checksum="D8BBCF2B6BA00807" modified="2018-07-18" version="1">MESTPPEEVYVDEFDPKEHQGCYIFTPDGEEDRPTKRRKTKGKQRAAEKTAIVEEKCPFPVLLDGKETESTLRLRYRTYCKLWEAQEKRTKAILDSFNSKTLDDVSAFVKDATPEKYEGKIPTALVLAGPNIASHELLFQQLAQRIRNQDKTGPVVALASKDATNLKTTLRKLIRDATQQDEGVDDEEEDIIRKSTKLLNYDLQILQTWCESHEGQKVTIAIQDSEAFDSNILSDLISLFSSYLDRIPFVLLVGIATSVEIFHDKLPKSTIRLMRGNKFDVERAEECLAQIFNDSMTSDKAVLRLGATVCDFLLERYRDHTQSIQAFVAALKYAYMSHFYANPLSIILGFIDNADGLGEVLSAEHVEAVRNVPSFRRYVEGKMAAKEVGEVRKLLTDDNYVRRTVAEKILESRNYGIELGQALAFLEIGRSCTLIQNKTPRYELYAKALSGELQTSPSVRDFLMSLKRMNSTTLLNLLEKVMQEVQAPAITEPLRPLQEKIKKLVEEAEASGGKKNLISEFDTTNNTLRGTAVSKKVRLGEQKSSLTKQDTEYSALVQQVYTISESYLTTNFNSSQHGLQNVLLHEILFYDLRSPHSAVFAPRPRSTIERGLSQPQDYLACSCCTSADGEEVGIRGTQPPTSIIYQLYLESGALINIYDLWSAFYSVIAGDEEDFDVPTAQALFYKSLAEMRFLGFVKHTKKKTDHIAKLAWKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0N7</accession>
    <name>A0A2T7A0N7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1113490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0N7"/>
    <dbReference type="STRING" id="42251.A0A2T7A0N7"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="65160" checksum="7F763F6F1BF49B20" modified="2018-07-18" version="1">MAVREPRRQNHRYFDFCMLGPRRTVKRPPPPTAVCEVVLPRDVHSRILGHLEALHKDLLEPSCPTCLARDLSSYSKVCMEWHAAAVPHLYGKIFIAGADSPELKKRMKLRNGCRAWLLRKTLLVRPDFAAMVKQLKLPEYQDLTAKESKENNKLVASIVQLCPHLERLEGHYPVYKVGVKDNIQTALLSRDFLKEHIWTIGSEGPMQLSQSESFANGHIRWTKLETLVLQGGPGNKAGSMSHLTFAGVFERLPSLKKLLVARFHDYEFDNNTLLAIPDQIEYLRLEELPGVTDAGVSEYVDRVSVCRRIRSLSLIELELLSTLLISKILSHLTHLEKFTLVQTSSPQLPPQSSAKKAKPTFASASLQLLHWDVLIPGPANVLLARSIHSSAFPALKAVRAPSDHHGIIQAVCKPLEHIVLPFDRFEARLLRARQKQREDKYFYPETRYSRSLPQARINAQERIEAAKESTFMRIVVTEGAAKKEGLSVDLKAFMGDWKSKVQYELLPDLWGDEFAVLTVSGLLNARVSTEWRPGDGVEMCSGRWNSTSFASGRGVKWWGHTERTPGMRDMELAMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A284</accession>
    <name>A0A2T7A284_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A284"/>
    <dbReference type="OrthoDB" id="5429256at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="211" mass="23324" checksum="70A2A12CFAEF570C" modified="2018-07-18" version="1">MAPLNSDTLRSLDQGLEKIISFIKSIPSYIPLSNTYPYGVESSHILDQVVPYIPPTPLTPSLLPVPTGFELKSPGPENVPWEEDPTLKKTNEYLELIENPWSYHRKRSSTGSPSITEVPKVLTHKIVQDYEPLAMALDGSGLGSSVRQLLGGGYYLTCSQELSLLIFIILAIVSIGSAILWTNSFSDFVSREDHAQNLKGKDYFRPVSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2D1</accession>
    <name>A0A2T7A2D1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_970128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2D1"/>
    <dbReference type="STRING" id="42251.A0A2T7A2D1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="858" mass="91650" checksum="87A771DC01CEB1C2" modified="2018-07-18" version="1">MAADNIVLQSSTSPNSPPMSSSYAGVNNSNKTQPPPPPPPKTDKPRPHVCATCSRSFARLEHLKRHERSHTKEKPFECPECTRCFARRDLLLRHQQKLHMTTTPSSRPRASGRRESTSSVTSTNPGRVRKNSVSTTATGPVSHGDGGASAMRARPRANTIAHVDSSTLGMLAAANANVNRGRSNSSAQGNVGGTGVGSLNHEETRYVFPKNTRPWGAWAHEGPRHTVPKIDTSLSSLDLGGMMPRSASMLPSEYELDGLLFGGTVNPAALHFNMSPLQQPIGTPTSPFGPPFPGLDSSYYIEDDDDYEWMNTLGGSLMDPVDQSSPSAFSTTSASGISEVILNENPGWGGQMGMGAGSGNSINFNSPNDFSGPNFHHETPPPPGTISPKSLLAQQSSHENYYSGSLSISPSTMSHHFPPFNHQYGPNNRTSSATSLHSNGGSSMTSLSAESVTDATRAALLATLAQAPSVFNSQGTQNYQPSRVHQRRYSTSTQPAPGTTNFSPFLGKTTGVPSTADLQRYVGAYIKYFHPHLPFLHIPTLNFNSPAFTNSVKGGQRNNGVIGGGGCLVLSIAAIGALYEFEQNVARDIFEASKKTIQIFLEDRRKADVTAALSGLNTNGGSGGDSGTNTPIWLVQAMLLNVIYGLQCGDKSACETAVTHCAALVGLARAAGLTRQPHVSARQTFKQEDGDIRMGDLEPYGGSVGSDGWGGINIKMEPDENVEWSSWVIAEERKRTLYAVHFLSSLLVAAHNLSPALRNNEIRSDLPCDEELWSAGTAAVWKSRGGLALASQNSVNFTSALTGLLSAGQQTYGSPGQFQNFTNGQQGGHIWVPSLDLRTSCLYLGNETKTKLSPLDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2X5</accession>
    <name>A0A2T7A2X5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1075758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2X5"/>
    <dbReference type="OrthoDB" id="10412813at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="190" mass="20639" checksum="2940A586F0920F26" modified="2018-07-18" version="1">MSLPLTPPPTPIKSPRRKYKKAPPQIAVTTFFALTPAILELYTIYPLSVPSKGLIPPPDAARAAALRFLTELHRQAHISANALGSGRPVSFVSPDKRLSPRSSGFRVDCDVGGYRTALERLEMGLEGFLEEGEHWWAGSMLEDVKIALGLLEGWNGTGEGALEKDVKGRPEIDECYIEVLRSLLGSESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3U5</accession>
    <name>A0A2T7A3U5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1074836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3U5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3U5"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="253" mass="27701" checksum="FFAE3A526C22B326" modified="2018-07-18" version="1">MADVRKLLQAERRQREANNKKNPAASPPPRASGKRPFSESSGSSSKRTKTSAPTTANLPADFFFGEPVSSSNERVEILDSRASKPTTTTTDDDPMSEATTSLPQDFFQKNNLEDVDEDEWAAFQAEVAADSLSAATPGAPPVATVITAAPTLNGPGGEHEQRVDDEDEYGKGEEEDAKQKLLDEFEEMESLEQRVLRLKERREALKSKHPIMGTQMEVVEVEVAGGGGLDDGDDDDDDDEYEEDDDFFRARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A410</accession>
    <name>A0A2T7A410_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000027">
        <property type="protein sequence ID" value="PUU82481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A410"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="12687" checksum="70F0C9351F42F0D4" modified="2018-07-18" version="1">MGPRGIKFLTEGERLAALETEHAFYKGSIVDGIKTNSKDLTDLNGLWFFTALFGFGALVYKTMICDGNSEDRIKRHIDNAVAASQLETAKDIDHAVAVSQLKTARALIKENSAITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A413</accession>
    <name>A0A2T7A413_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1190353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000027">
        <property type="protein sequence ID" value="PUU82483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A413"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="31209" checksum="6F4C215FC9001D44" modified="2018-07-18" version="1">MPDFLGVRDAITKPFYDGVLRHPICPPPKGHPHTSIFHGATESSEGGSLCRIPGALGMRSRSPFTTAFYPIPSAHRQKDVSIRAFSMALQNSGGVRHAIMKPFYDDVLHHPGCRPPKGRPHTSISHGATESSEGGSLCRVFLVLGVYRVLTLKPDSQSVKHAIMKPFYDGVLRHPICPPPKGHPHTSIFHGATESSEGGIPGALGMRSRSPFTKAFYPIPSAHRQKDVSIRAFSMALESSLKGESLCQIPGALGMRSWSPFMTAFYTIQAVHRQKGVSIEGVSIALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4P5</accession>
    <name>A0A2T7A4P5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1190200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4P5"/>
    <dbReference type="STRING" id="42251.A0A2T7A4P5"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="584" mass="63340" checksum="E611D7BC9C71583C" modified="2018-07-18" version="1">MGKKSRSKPGPSKSTSLVLADPAPSEKKTKNKVPAQEKDAEEEFLEKLIFGDAEGFEAGLNELDGGYSDDSDREEGGGIALAGDGDGDVDAGEDLQALRDDELFFVDEGPSGMDVILTKGPEEGGEEEEEEDDLPAWQDSDDEMLTISLANRGLLRKLRDTESEDLISGKEYSARLRRQFERIYPVPEWAAAAGGSDRRKRGGSSSDEEMGGVEEEGGDEEAVRSAPSLEEILRSTTTNWTRKVPGRLRPEKLTIVRLADGNRIGGSLSMISTLHFHPHHPLLLSSGPDSTLRLHHINGTTNPPATSLHLRNTPISTAHFHPSGTSIIAAGRRKYFHIWNLSTGTIQKVTRIYGHAEVQKSMETFRISPDGKFMALVASRGFVNVLNATTYQWVCAAKIEGRVADISWWGDSHGLTIGNKAGGVWEFDVLSEKVVARWQDEGGHATTVVKNGGNRWIAIGSQSGIVNIYDRTRSFGTTTSNTSNNVLAGGTKEKPKPVRVLEQLVTAVGVIEFSPDCQVLAIASKGKKDALRMVHLPSCTVYQNWPTSGTPLGRVTAISWAGKETGIVAIGNEAGKVRLFEIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A535</accession>
    <name>A0A2T7A535_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin cortical patch SUR7/pH-response regulator pali</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A535"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21157" checksum="DA0643264B48721C" modified="2018-07-18" version="1">MTRKIIYGASLAAFVAVSILTLTSTIIPRWASYVELTKTGPITYHYGLHKRCSSLTGTCERFPTYSDCHGRDRYFCSMWRSIAFLMSFALVLEGAIITAFVAILMGGRAKRENGWKVLVGLVLICAMSQCGAVALVAYLYDYDDRFFVGWKLDLSWVMTTVSWSVMLVIGGFVSIAGWVMPPEGGYELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5F1</accession>
    <name>A0A2T7A5F1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5F1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015724513" description="Yippee domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9528" checksum="657A780DC31CF57A" modified="2018-07-18" version="1">MVLTLVLSWLYNFSSHFFFLDDIGDNKPLESDLRTVDFGEVTGNLRFEGRGDGGHRRAIRCIQCDTFLLRVPFSGGLRMEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5F5</accession>
    <name>A0A2T7A5F5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1040131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5F5"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015786677" description="DUF7492 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="3">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="272" mass="29001" checksum="1D0E0C7B101485BD" modified="2018-07-18" version="1">MHVPTRNPLQFVGVALLALISGVHGHSWIDSLSVVSGANSAPFKNTTTIQQGPPGAGQQGTGLGYIRAYQGHIDATAVYLITAPKLDSNICRSSQQQNPTANTAQFPRLSASPGDSIQGTYLKNGHISKPDAPDGTPGTIYWFGTANAKPDDTLANVKQWTVDGKGGDGRGKLLANPSNFDDGTCVEPNVTPIANQRTAAGCGGPCKSAFKLPQDAKVGSTFTVYWVWDYSNHFGPTKKGHVEWYTSCTDIQVVAPKRKRFLNGSAKFRGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5L3</accession>
    <name>A0A2T7A5L3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5L3"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53830" checksum="F38CC32FA79C9FFC" modified="2018-07-18" version="1">MTSHLSTTTIMSSLRMPPHGLKQLKDCRYHRHLFHPFLKAYGLGFLYYLSPRIIGLVLSKVRQRISNKKNNVVSPAIIDIFRKSSELHRFPAFCGVIIGGWHVLQPIFEKCLETVGKFSESLGAEKTTGEQRRRVATFLASASAAAVAIRQLNGRSVESPAGRTLDLTLFAIVRALDVVIGEIWTRRKAHQIHSKTFTRLDRIIEDNAAAAIFAASAAVIMFSWLYEPERLPSSYNKWITEIAEADTRLVTTLRRIRSGEFVYGKETGQAPLLQSLCEDLGLPRVWGDPAVTKRIPCEVVHHGFSKSCELHACWRFWNAWKAAFTMYLGLNFLVRLRNGLSIHTSLRAISDAAKSAAFLGTFVGTFWYTICLTRTRLGPLFWPQSDQLFLENLCVKMGCLSCGWSILVEPAYRRLEMAFFVAPRALGTFVPRKYNRKHLWKETLAFSISAGIVFTALKENPKRVKGVFGRFLGSVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A644</accession>
    <name>A0A2T7A644_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L6e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1073264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A644"/>
    <dbReference type="STRING" id="42251.A0A2T7A644"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="194" mass="21739" checksum="FE3F3FA6119CE05F" modified="2018-07-18" version="1">MSAENKQVRFGSGKREIPAQKASKWYPAEDEPVNKKVRKTQKPTTLRPSLKPGAVLIILAGRFRGKRVVYLKPLSGGVILVTGPFKLNGVPLRRVNSRYVIATSTIVDISGIDLEKFDEKYFAKDKEAKKSKEEKFFEAGKKPEKKPVPEVRKADQKEIDAAVTKAIKQTPHLSAYISSTFSLSKGDRPHLMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A684</accession>
    <name>A0A2T7A684_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A684"/>
    <dbReference type="STRING" id="42251.A0A2T7A684"/>
    <dbReference type="OrthoDB" id="21595at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF14">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="608" mass="69898" checksum="218A4BE46F5F3264" modified="2018-07-18" version="1">MASVSSLDRDLSRLRLGKYTPQASQEIKDWIAATLNENLGNEDLMLILRDGTILCRLANLLGESPQIRFKKSAMPFVQMENISHFLSFVASPPISLPPHDLFLTVDLYEQKDPAQVCQCITSYSRTAHKLKPGAFPTTIGGLKVTAQLSPQLSGGGGGFWAGGGRKVSGGSVSSGGGSSVVSGYSGSGSTAKPSVPPRKAAVSTWSRSSDETATLPAWNIAQYGYLGGASQGNQGISFGARRQITNNPVVKSTPATSPPPPMSLAERRRREEEARKREAEAEEERKRELQAADERRRAVEEADRWRKEEEEKTAIELERRKWKEEEERRKLWQREQDNQRELERQKEEYAFKRREEEARRVRDREAQIRLDREKKERERERERIRELERELEKARERERIYEAEKEERRRQDTERMRRDAQEMAIRRHRTGEPPSTPSSSEVNFVRSHRTGDRDRDQESERMFLQTWQNNTPPPQTPPRHKQLGSPIPQPRALPTPPPRKLPPAPIANYPSTSNGYYAAEPMQPSRSWETNDDASGPDREQEELEKQQAYKWASMSLLERERERERQRQKEWEANQREVEQHVPTATTEDVAWDVNQYGYADDILDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A699</accession>
    <name>A0A2T7A699_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1112533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A699"/>
    <dbReference type="STRING" id="42251.A0A2T7A699"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="527" mass="56963" checksum="169886C90B1844D2" modified="2018-07-18" version="1">MARENECALEESEVREVRVEPKSGADPAREYMTGWRLHVLTFGITLALFLSTLETTIVSTSLVSITNALNGFGRGTWVVTSYMLTYTGFLMIYAKFSDIFGRKPMMLIALLVFTVFSTVCGTSQNMLQLIIFRAFQGLGGSGIYAMVTVIGSEMVPPEKFGLYMGIISSVFALSSILGTILGGAISGNTTWRWVFLLNAPGGSGALALIALALPPNFPSPKLSKRRSLGEIFSKSAFRRLDWRGTALSLAASILLVGKVISTFVISALCWVGFVLWERVVERHAGGIQEPIFPWRVLKNRAAAGFSFLGAVIGLPQRFQIVNGTSPAGAGIRLFPMVLAAPLASWFSAILTSVAKIPPFYVLTFACSLQVVGLALMSTLPTDTMKIANAQYGYEVIMGVGFGLAIPTAILMVSLFVEAKDQAVVMGATTQIRVLGGTLCLAISATVLSNWVKSQLPEFLNPQQLAALLRSSQALEVFDPEIRARVRFVYAEAYNQQMILLTGFAAASLLSLGLSFEKKARILDTARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6E4</accession>
    <name>A0A2T7A6E4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GPCR fungal pheromone mating factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_921938</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6E4"/>
    <dbReference type="STRING" id="42251.A0A2T7A6E4"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004933">
        <property type="term" value="F:mating-type a-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001546">
        <property type="entry name" value="GPCR_Pheromne_A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00900">
        <property type="entry name" value="PHEROMONEAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="33909" checksum="8105648D8C01BFE5" modified="2018-07-18" version="1" fragment="single">LSGLSTVVAFIPLAWHIRNKNTAAICLIVWITLFNFLSFSNALIWGGSEFDIYTAWDGKIFCDVEVKFFIASGAGIVSSIAAIARNLARVMSNKVTVIKTKQVRRRELVQDLLLCLGLPVWTMAIHYFVQPSRYLLLATTGCTPTISDSWPSIPLVLIWPPIISLVSAYYAGLVLVRVHRYRQQFADILRSSNSGLTTSRFIRLFVLSLVLLVINLPLTFYVFYRNMEQPWTPYDWDSIHGKDWDYILRIPSHNIIQFDRWVSVGAGYILFFIFGMGNDALKMYRGWLDTIGFGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6P1</accession>
    <name>A0A2T7A6P1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6P1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="70" mass="8233" checksum="05B0249210E8A785" modified="2018-07-18" version="1">MARNPRVARPISEYLGCRWFILFFALILFSFDEPCAIGGGLDPLWPFLFIFSSGFFIFYFLFVFFCPIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6R0</accession>
    <name>A0A2T7A6R0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1072834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6R0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="19319" checksum="7DABA6363FA49305" modified="2018-07-18" version="1">MADSRGIRNAITKPFYDGVLRHPICPPPKGRLHTSIFHDATGSSEGGSLCWVFLVLGVYRVLTLKPDSQSVKHAIMKPFYDGVLHHPFCPPPKGRPHTSISHGATEFSEGGVLMADFGGVRHAITKPFYDGILRNPICRPPKGRLHTSISHGATVFSEGGVLMAGLLSADLIARFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6T6</accession>
    <name>A0A2T7A6T6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1189573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6T6"/>
    <dbReference type="STRING" id="42251.A0A2T7A6T6"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="4">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="704" mass="76114" checksum="A6DCE513485B7C4B" modified="2018-07-18" version="1">MSFTMCLATRFGLGEHHDSVNDLTAPPSKNPALMATKTSILVFYLGLSKNYRLLRIANWTTLAVVNFAGLALTLSIALQCDPVSAKFQSSLPSFKCMSTYKLLYASGPINLITDLAILILPMPILTSLRLPKKQKIILMVLFATRGLKVDNSVPKSATIVGIVRIHFFQRAVDTSLLNCDGSLSFMWSSIEVNVGIFCASIPMIKPLVAKIFPSCIGVTGDTPTAASLIHASGAPTSLSADDRPPAFFDIGRPKSALAFDVRESIRPLCQIAGLFFLWGFAYGFVDTLNKRFEKLIGISTEQYIGLHAAYFGAYAIAPQLIGGTVLKGYGFKATIMAGLTVARCGCLVFWPSAVLQSYEGFCISMFLVGMGLATIECAANLFMILCGPAKYSEIRLNLAQGVQPVGILLAAMLASNVLPTVPEKRRGSLPVTSLINAQWIYLGFGIFSFILAFAFYYADIPEAKDADFSPEQSGTDNLPQLLLRSEHGIGFVWAFVAQLLYVGAQEVVMSFSIVYLGKAIFEDSPHIFTGQSLLSAGRFIAAALMLAVKPRWVLLAALCGGGIFSALAMTVSGDRMRLGMLLMVWLCASSCFPTIFALSIRGLGVYSKDGAKNQITAVGAGAVFPQVYYAVMRSKGGGSWAARYAMCVPMALFASAVTYPTYLCIRPKERERLRRVERGAQPPTPCKKCGVGVESEHIEMAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7T6</accession>
    <name>A0A2T7A7T6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1118736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7T6"/>
    <dbReference type="STRING" id="42251.A0A2T7A7T6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="385" mass="43999" checksum="705081DE8A809C3F" modified="2018-07-18" version="1">MNTKPQILATEIFAEQHSELSLMLGLIRLWSGSLTTAIGNGKDGEGSYQMCLHVLCENFIWTVIAPSWLLEMLPFKALREAGGAASNFRFFMNEWFEERKAKIELDNKTALKPPSTADLMESLVRSSGLDKGSTLETPLLWKSEVIGNAFIFILAGHDTTGHTIANAIYFLAMHPEYQVKLQEEIDSILGDGDHHQTSYETHFDTFSSGWRETIVRNSPPHSCSDHSKPPNRFHPPHLPSHRQSGTHHTPSRYQILDPNNRPSHNPKYWTQLEKTEAESGISKFRPERWLPKLGDNAMFKPYNESYIPFSIGARGVYWEEDAYIEFTAIILGLFREMSVEFDSYRGRKAFDEAKLECLAQMSKFKMKLSLQPTGEMPGIKWVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7U5</accession>
    <name>A0A2T7A7U5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7U5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12723" checksum="1E8248085F6A50D2" modified="2018-07-18" version="1">MGEVGEGGGMIWGGKVEERLRGGMVGVENMEEWSKRRNGLEGEREGKVKRRDGWSGECGGMVKEEEGLEWRKVWRGNVEEWLRGGTVGVENLEEWSKRRNGWSGEMDGVPGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A801</accession>
    <name>A0A2T7A801_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1060748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A801"/>
    <dbReference type="OrthoDB" id="5400059at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="169" mass="18344" checksum="BEBAD148BB380F9D" modified="2018-07-18" version="1">MCAHDREETPDNFTPPRTGYSVSCQGISSVFYPKIAVATSDGAQLITVVAPSSINGNENCQLVGFLLGVAQKHFSECPSSSICAVNLIRLTDTFVVYFAKAWVTRAYLASVCSGMDGVDDLRLRVHISDAFDLGVVTERIRFVHTLTDLYQTALDNAGPILPLNALELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A887</accession>
    <name>A0A2T7A887_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A887"/>
    <dbReference type="OrthoDB" id="5401882at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="22557" checksum="890967573FE99C80" modified="2018-07-18" version="1">MPASITAITAPIDPKESSSSFVYKRYLHKLPHSVFFIVKNHSESAACMACDETPCMALNQCTKCDLQLCSACAFILVHGNCRGNLKRLIAQVARWKLGYSVEFLEREAEEERASRMKELERGSGADGNDDGYHQEEEREELRAVERYMCAINDGRLWKDNASESSTDDESLDLSQETGEDSFETALQEWSALRGGGSEEDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8X5</accession>
    <name>A0A2T7A8X5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8X5"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="240" mass="28248" checksum="9CB6DBEC93ACFB09" modified="2018-07-18" version="1">MRFSKSPIRFATSVHTDTFRHPTDRVRTTFDCCRKQTTNHVQQRGEPLISMHEHNARVFWGKQDIIRYREQHAELSQHFKDQLKFLQEPQEALINDLFEQKEQDRKRIQQGIIRNCELLYAALKERTEKMIVLGNCGLRGALDPTNCGVQEGLDKLAQRSEFTEVLHKEVQARKLVVEDVMACLNHVYDKVCKRTKDMEDAMVVVRVARYTDNERAALVVFLKLQDNWLYPLDWIEDMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A945</accession>
    <name>A0A2T7A945_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1118126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A945"/>
    <dbReference type="STRING" id="42251.A0A2T7A945"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="234" mass="26553" checksum="0884E1E9EE23E739" modified="2018-07-18" version="1">MIDRAHGRNVHIYDPRDPETILGGHFVTNGMTNTNFYFIIDIIIKFTTDYTLHRGQKFGPTIQRDNNPLEEGKYFIVAAGEFTINDELVVNTLKSLSAGIRDHEFRLAMRAQDRGWAISGSAVSQFNLARGYWGGPAYIRFNDTLVGRRINSVQNGLLLRADIHLYFDDYMLSINPDDNYMIVCFMDDPLLGVAGTHCDHMLRAPQRPSLYRATTVAFQAGSASKCKRRCIRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9I0</accession>
    <name>A0A2T6Z9I0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1012661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000717">
        <property type="protein sequence ID" value="PUU72152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9I0"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9I0"/>
    <dbReference type="OrthoDB" id="5420958at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="9372" checksum="42837FC4BC1678A3" modified="2018-07-18" version="1">MAINRAAPSLTAAAGRVGCAPSTVMHRKKGRKTRKAEEEKRQNMTPEEKDQVLERCYFRCRLGFPPTIWQWKDIAYLIVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA19</accession>
    <name>A0A2T6ZA19_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000568">
        <property type="protein sequence ID" value="PUU72338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA19"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA19"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="163" mass="18444" checksum="04B10D4BCB3DB955" modified="2018-07-18" version="1">MEGLFKDKLNSCIFLGISAEDTEEEIFGFCYHLIEANEHVDLMGTETVSLEKQITELDATCTVTKKTKEDLETYIKPILSTLEEEVPLLGTKMADLKTIRNEKDKDKLRLVNIQYRVSTTLMRTLFNLTLTTQAVTMEKESLKIDLDKATRNLKPTATPGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAH4</accession>
    <name>A0A2T6ZAH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000520">
        <property type="protein sequence ID" value="PUU72497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAH4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14069" checksum="028AFED977DAA879" modified="2018-07-18" version="1">MMSTRRSTMRKAEVDQEMIAELNKILEQEREAILADWRPYYPNQFDQDGSPLANLPIPIEVDSLPISPAPFVNPSPILPPMARMKSLLDRVVKRPRSSYIGSTLSANSPPNTPPSRSSTSTHPLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB17</accession>
    <name>A0A2T6ZB17_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1111616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000481">
        <property type="protein sequence ID" value="PUU72690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB17"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB17"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="48"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="486" mass="54196" checksum="76DB64AD998CB032" modified="2018-07-18" version="1">MATEQPTSNGSASASASAPAAAAAESPRSSPKKSSAKSDESKNPKVSRLVLCFDGTGNKFTGDASDTNIVKIYQLLDRGAKGQFHYYQPGIGTYVTGTSSFTPKIWSRFTNYITQTLDEALGTSFADHVVQGYKFIMRYYTRGDDIYILGFSRGAYTARFLAQMVQTIGLLSRGNEEMINFAWDTYAKYEQRGTDTDYKAEDFMKQFRDTFCRKDVNIRFLGLFDSVNSVGSFEIPGMRRSFESISVPPALHVRHAVSIDERRAKFKPALFDDRGGGHDIKEVWFPGNHGDVGGGWVPGSDGHLLSDIPLAWMINEMKNLPDVEKPLAWLEGAGDVMHHDPVKSPHIARTAVMAKIHDALAFAKGFSWGNVFGWWLIEWIPLFSRRELEDDKWVARRIPPNAGEPRDLPSGALIHPTAHLRELEDPKYRPKNMNYRSAVGPGQPTSRKRESSWRTWQNDIVGKRWNIVDAHEGQPLLNGGGGALTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBE9</accession>
    <name>A0A2T6ZBE9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1096677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000474">
        <property type="protein sequence ID" value="PUU72744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBE9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="63" mass="7348" checksum="3E13F8706A740C1E" modified="2018-07-18" version="1">MMSNAIDQITKPGHNSIRQLILDVKELSSYYSQTHDVCENNWVRIDSQDAVHQTRTQVPLRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBW3</accession>
    <name>A0A2T6ZBW3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1007390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000446">
        <property type="protein sequence ID" value="PUU72904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBW3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBW3"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU72904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="400" mass="44029" checksum="8ED7F515D5BC6FF2" modified="2018-07-18" version="1">MGRGSRLTRLDAFTKTVEDARVRTTSGGIVTLVSLCVVFILVIGEFREYRRIQVLPELVVDKARGEQLPITLNITFPHIPCELLTLDVMDVSGEQQSSITHGVRLTRLTPFPESKPVSATSLNLHEDTASHLDPAYCGKCYGAPAPEKNNNGCCQTCDDVREAYASIGWAFGKGEGVEQCEREHYAERLEEMREEGCNIAGHLSVNKVIGNFHIAPGKSFSSAQMHVHDLNQYFASPKEHTFTHTIHRLSFGPDLPANVKVQRNPLDDTRQVAHERSFNFMYFIKVVSTSYLPLGASENSFTSGTVETHQYSVTSHKRSLMGGADKEHASTIHARGGIPGVFFSYDISPMKVINREVRAKSFTGFLTGVCAVIGGTLTVAAAIDRGLYEGGMRVKKLHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCQ2</accession>
    <name>A0A2T6ZCQ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M24, structural domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1111307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000394">
        <property type="protein sequence ID" value="PUU73270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCQ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCQ2"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="400" mass="43661" checksum="C924A248A6B6AFF7" modified="2018-07-18" version="1">MTDKNEKADGAAAAENSPENEFTLSLTKYNDAAAIAHRVLAKVCKLAIEGDGKTILSLCEEGDKLLDEECSKVYKGKKISKGIAFPTTVSPNDILTPYTPLATDPGENEIAIKKGDVLKIQLGAQLGGYPAIVGDTVVVGQDAELTDDQKNLLLATHYCNEALLRLLLPSEIHPLSTPEKLHKQPSAYEITQILNKIAAAHDCTIVESTTSFNFLQNEIEGKKRLVLHPGEGMPKSEGTPEVGDIWGVELALSKGSGKLKDVPGKRPTLHKKTDTKVGLKRQTSKTTFTEVNKKFGNFPFGLRQLEDERTAKMGIVECVRYNVIRQFEVLGEKDGSITSRLFSTIAITKTGINKIAAPPEPDLEKLKTDKSIENTEILDLLKLPLNKPKKKKKPAAKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCT2</accession>
    <name>A0A2T6ZCT2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1095409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000392">
        <property type="protein sequence ID" value="PUU73279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCT2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCT2"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SPRY" evidence="6">
        <location>
            <begin position="231"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="387" mass="41496" checksum="8DA0758A1718D8E2" modified="2018-07-18" version="1">MCFGRRGKKSLLLSSKEDKNNSNNAQYRYNISSPTPTSTRAHYPFHHHTPPPPSSSQQHQAEMAGPYNPTASSYTLSQNRDKPSTPPPLGGGGSSTTDFVPPADPPPPFTPYSSESDLPPPPPVISHDTSPTSNAPGDLSDAGYTFCHQNPLTPPQHLTTASLREISIGALTLLPPPHSNHHNSNSLTLTSAPKSSLPIVSTAAGCLDTTLLSSQPLYAAGYHHPANTHLPKRIYFEIRILRLPPRPQEATVAIGFAAKPYPSFRLPGWNRGSLGVHGDDGRRYCNDSYGGKDFVQGGWRAGERVGIGMCFGTGDATGGGGGAKAGGGEVWFTRNGERIGGWWLDEEVDAERDWDPKVGLDGRWDVYAALGVWGGGIQVEVLKFESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCX0</accession>
    <name>A0A2T6ZCX0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Vps53-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1095227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000386">
        <property type="protein sequence ID" value="PUU73340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCX0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCX0"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="9">
        <location>
            <begin position="620"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="72"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="858" mass="93979" checksum="ABB11D6480B7640B" modified="2018-07-18" version="1">MFASNGGFPAHGGVPVDPLDSADYDPIIHLNTLFSHPSTLSAVPSTSQALHNHLDSLDNEITRLVTTQSTTNADSLARISSAKAELADLLENIDTVRDRAIRTEDAIAAMTADIKKLDSTKRNLTLSMTVLKRLQMLTTAYEQLKTQSKNRQYRECASLMSAVLELMAHFRSFRSIDQIATLSRNVADLKAELLEQVCEDFEMVFVKGEVSARKGMLSEACTVMDALGDGARARLVTWYCNTQLREYRQVFRGNDEAGSLDNISRRYAWLKRILKVYDDEHIGIFPLSWKADEMLVKSFCDGTRDDFKGILQRAMRKESGKSLDVNLLLKCLQETLDFEHYLERKFSADRMSIDTVSSRDERPLIFGKAISEAFEPYLSLWIDDLDRQLSTMIPKYRIQPLRPGDEDFTPSSSVLPSSIELFHFYRLSLAQCAKLSTGSKLLDLSKIFAKYLDQYAEAVLLNYFSPMEKAGALAGEDIVVVLNTADYAHATTQQLEDKIKSKVDPEFSSKVDFEKQQDAFLGVVTTAIRLLVRKVESAAEPAWREMRNTPWSRLEAVGDQSGYVNVLISSVKETVGEILELTGKETYQRAFCDKVVEAMAAGFLGSLVTCRPIGGGVGAEQMLLDAYVMRKGFEDLLTLKAEPGTAPPASYTKHVQRSMSKIDTLLKTLQVQSSPPECLVQAYLIHVGDKSDTNFRKILDLKGIRRQDQASFVELFRAHMVTHDNLAEANPFISALLVPSGNIGAPSGAGGMGGVGGSGTIGSSGVSGLASGVGGLSGPSGLVPARFDPASLGSAIMNAARDGVDRLQTPVSSSSDGGNGGQNQVESGERIFERHLGRLFKRDGGGIGMGGRFSRDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD48</accession>
    <name>A0A2T6ZD48_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1103939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000379">
        <property type="protein sequence ID" value="PUU73399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD48"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="223"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="378" mass="43620" checksum="A6A63FC0972E50AC" modified="2018-07-18" version="1">MSAKPHFCLTELQSPPPAHERPSSRIPGNSSARTYPSGRRKLSEKLILLPEIDEEANRWGYGEDDIEDAPIEDNEEEWRNRLNGDEESPEQPPWNSYAKRLPKSRMADKLSRCLYCAYHLPIMSDDDGYRVRSSPILKCPGSKAIFDVKIERSEQRDYHEGCFEDSYTGDYEEDDHSKSLGKNYILADLTFSQNDLNIQLISGRLNKDEFETQEFHFQYSSSTRSPRLYRFEERMNTMLGVQQIPKKLALTGKLGMKREEVVKMSGRLFKPRVDVNHWIASNVLNLSEFLWDAEPTLHPLYAAVREYLEIKQRILVLNECCRVFLDLTEILSDPIADSNMSSITWIIIILIGLSIFLTAAKVTIRFRLLSSMKEVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD95</accession>
    <name>A0A2T6ZD95_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD95"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD95"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="61686" checksum="AFD145A24415EB38" modified="2018-07-18" version="1">MSSASNPDVNLNPYTFTSPVDRCKYIVKPNPVTKLFHSFCCDKGYTCADGRALGRHLRRKGHVDPSEWTRGYKNVIQVVHSSKETIVAEPDQNISLGPFDLRLVDRQQVMSLALVPESAAPILESPCPIPESPAPVPESYASLLESPAPIPESPAPVPEFPAPISESSAPVLECPPPIINESTFPYMELGLFRDLSTDWSLDWVSSDIQFSGSDMLDINAFGQGRVSEPVPLQDKRDFFEGIPLQDKIDFFEGLEKVGMEDTALSPICNSILQPLPTIHDSSSSYGTGLEITSSLAKELDIAEEFGPIENLHGHKIIWDNATAVAFFVEYNILVCTQCKKSLTNIGIVNHIRNSHPEIDSAAGQALEGKYANFLYSPNETPNPPPESCPIPFLPIVPGYSCPLCQYCIIESYNLVRPLRTVHQSVWSEKACPRAKLQTWYSGNTSRYFSIHKNKCSCCSPVIPSHSGQINITSILTNVESKIESKLEAHMRLLSQHDSFSLHKAFPKNSASSNDYERTPLDAWLEKTKWVEHFQTTELAQVVEVREELANQVQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDA7</accession>
    <name>A0A2T6ZDA7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_918549</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDA7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDA7"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="7058" checksum="391A4CBD6934D7C3" modified="2018-07-18" version="1" fragment="single">GATLVRVFRCILLDPDWEISRENQAIARIHRCGQRHRTTSYKLYCQGSFDEKVIAHQNAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDJ8</accession>
    <name>A0A2T6ZDJ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000368">
        <property type="protein sequence ID" value="PUU73571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDJ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDJ8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="741" mass="80799" checksum="09CC8EBEFC31BFA9" modified="2018-07-18" version="1">MPITTTSSSTEAGSSPARAEADHRHGGRKASSRPLKPLKFASLTSAVQKHYPPDLGLNQGGGSFVSTIPETSVKFTGLTREVQREGPVRPLQAHLDGLTQAEIALAVVDLLNLHYQHREVLGGWEKKIDAESDHSSILSEHYLREMAKLANRGITLLDAQEVLNYVMKTRIARPGKGVRTTCVIMIIARPHAPTTISSASCDGTTPPNGLPSPQPTPSSKRPRSGSNHNQLSQTTHHISSPIQSPMQSPVHSCRQSPALPDTGEPRPSPRSPSPRTGHVTPPVQSVSDSSPTPGTYQVDSNEGDIDPNEFQPLAAGQTSPHQLLITSIARKKKESTPKRHSTSKGRSAPKRHALQVPIPALDSPLQSPPPSPPPVIITHPLAQSTSKKRLYSEYASEDNTLPLRDATPTLDSPLQSMSNSASAHPATITQSLDYTPEITALPLSHIFSLPDNWAYDSGIHTSVLERGFYNSPDALIQHPRVYLTALAAMKTTNHRLISLPVPLIDCSDCYQIRDSLFPFEKYIASEKEVLGTRLLYPLNASTFRIGTISTQERVEAWWTISSGDLQIAASQIDPEDVLTVPFQAGELIAMPPQLLWSAKADNAQDDCSQGHSSDSSQIRSKIAEIRYISLTPDQMLEFGYWPTGSYDQISRLGRGNFPGGKRPQTAIQMRGVWAIGDALLGLTSWDSLVVQVELRELFNAPAGSWFNAKFVNKIEASFDRKLTRMVKTLEKVNKLAFSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDM9</accession>
    <name>A0A2T6ZDM9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1003983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000364">
        <property type="protein sequence ID" value="PUU73595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDM9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDM9"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000085">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="27687" checksum="3B3940D9268894C1" modified="2018-07-18" version="1">MRKGVGLGALTRNTQSSQQYASHGQLLQKSHIDELTTQLSVFQASLSQFSRTHAKDIRSNPAFRAEFARMCTAIGVDPLASSSNRGGSFWAEMLGTSVNDFYFELAVRVVEVCRRTRQENGGLIAVAEVRERIMRQDESIGGSSDVSEDDILRAVDALKPLGSGFAVIDLGRRQMIRSVPKELNTDQSTVLEAIQVLGFITHSMLRVNLGWDGARVQTVIDDLLSDSLVWLDGQADEREYWAPSFFKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDY5</accession>
    <name>A0A2T6ZDY5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1094513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000351">
        <property type="protein sequence ID" value="PUU73710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDY5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDY5"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16772" checksum="B8279DD5BA49E2E0" modified="2018-07-18" version="1">MIDWDSVATHQAFAQSAEYPATIEAVEFLASSFSAPHVPLQPFPPNEVFASSPVVSWVTFNLTGVANDTAATAAMNWQGMADGFLGNLTGVSGCGAYSSGWEVEDGRVFSVLVGWESVEALGAFVVSRRFVEGFGRLVSGVAWEYKVLRVAGYVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE95</accession>
    <name>A0A2T6ZE95_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE95"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE95"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="172"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="479" mass="54794" checksum="F31210B99D185DE5" modified="2018-07-18" version="1">MLKFESLSVQPKPPAASRGHTPSPPLPNGPVKSFSDFMNQTDDDWDADVGDETPDDFLQRKLKPPLSIEPRPVVSSKLRGPSSSTDLASKGPSYPSTRRKDSQGLKPQFEGLVRDPGNSLHMIYHPTLSLETHTEAEIERLNARIKRINKFKRILQSSTVDLNELREISWNGIPDELRPMAWQMLLGYLPANSDRRVSTLERKRKEFIDGVKQAFVRGTSGLDQTIWHQISIDVPRTNPHLPLYGFETTQRCLERILYVWAIRHPASGYVQGINDLVTPFFQVFLSAYIDGEVETFDPSSLPKEVLDVVEADSFWCLTKLLDGIQDNYIHTQPGIQRQVTALRDLVQRIDVGLTKHLSEQGVEFIQFSFRWMNCMLMREVSVKNTIRMWDTYMAEGQSGFSEFHLYVCAAFLVKWSDQLQKMDFQNIMMFLQSLPTQSWGEKEMEILLSEAFLWQSLFRNSSAHLRQPTSNASLPSITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFE3</accession>
    <name>A0A2T6ZFE3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000314">
        <property type="protein sequence ID" value="PUU74217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFE3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFE3"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="270" mass="29690" checksum="6CF780C8D6A18243" modified="2018-07-18" version="1">MLIQETQCDVQTTVSGTLMRIYLFHPSIPNYPKAKFPGVVVFSEIYQVTGPVARFARQIAGQGYICAAPSSFHEFVGPEPLEYDVQGTDDGNKFKITKKVEAYDEDARLAVDLLIGLATCNGRIGATGMCLGGHLAFRCALDSRVSSAVCYFATDIHCATLGLGKSDDSLKKAGEIKAELAMIFGKMDNHVPPAGRDLIRKELHDKGRLFSFYEFTFAQHAFIRDELSKGRYDPAISKICFEVLLELFGRTLKTELGEAVVDSTPVENVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG41</accession>
    <name>A0A2T6ZG41_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1158408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000299">
        <property type="protein sequence ID" value="PUU74439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG41"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="49" mass="5627" checksum="E33E1FB39815F835" modified="2018-07-18" version="1">MEFLEERAIWMGERNRTVVFTGPKVFVNGVWVGTDRKPPLMFSGVVQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG79</accession>
    <name>A0A2T6ZG79_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_436790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG79"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="19735" checksum="EF9013DE76EA059A" modified="2018-07-18" version="1">MASAPLPSSSAHLSADNPLEFDNSSSPSSSKEVTPTSSPALSRSTSFVGSNEDWGEAFPPLDKLTVFDFLDQFALPQRLERINEQINRRIQFQSESLKKHRDKVKLEYVKQKERVIKKKDVEFEKYRKRYSQGLEKVLDKWDDTRVVSTREKISFVVGVCNIFITGFLIGGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGH0</accession>
    <name>A0A2T6ZGH0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1158214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGH0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="38031" checksum="8CE9E7FB9CA0C450" modified="2018-07-18" version="1">MLGSYSTFNTQPTMPYHVGPQPCSPRQELQKIEAGSSGDYEFANNLQTSYTQRHLGHPLVEFPGYFPAEYSPQSPAPNDENNWPETRFGVPRSRSPWTLSFSPEAGWDWPHEADVHPFHGPHEKQILGLPGLGLSFQGAADDESDTTSSGSSSSSILRGYYPGVAASLLQTPHEASYDSSNFGLYQSTPGSSSDTNWGIQQSSRYHTESSFSSTQRDTPPTQLLAGTDSNFTPDYPTTHYNYQPLHSYHHAQSENLQDIKPSKRRGSYTCECGALFGRPGDLQRHMATAKVHGPAKGPFCPVGGCRYQGRFTRVGNLKTHLVKIHKISTTEAAWHIQGLKGKGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGP2</accession>
    <name>A0A2T6ZGP2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_998951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000282">
        <property type="protein sequence ID" value="PUU74663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGP2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGP2"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="77"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="716" mass="77675" checksum="227E1159E99A0D25" modified="2018-07-18" version="1">MAGRNNHIAGFPGSDVPPPLPPRRPVIPSSPPPSYSLLPSTEGSYSYSNPQEDYDLAIQTSATLESPSDSAPSGKRKLLLVYIHGFMGNETSFQSFPAHLHNLLSITLDDLGWGVHTKVYPKFKTRHNISVATEGFSKWLAQFENPNTDVILLGHSMGGILAAEAVLLRDERGGFRHRILGVVAFDSPFLGMHPGVISAGLGSLFRSEGKSPSEEGGPSEGGGVYAGANSSMASLSTVPSNSTVDEYFDRRPQRNFTIVQSKQEGTLDSALNFINKHHSRLTAATGHYLMSHLEFGGCLADPSGLRNRYNAIRTLETGERTLDGKTTRVRFVNYYTSSTGRSKDAPKPAPAAVHPEHSFDLADAGVEGSGGRELQEMTRDMHLGIDPLPSRAQGRNLSTSTVSSSGGEMTHRDPDPISDNEAFYETQDNPGGSTPVPVIETSVVGSEPRMPDYDPPSIPTCPTGSAPAPPVTSPPPPRPAEFDYSIIPDPTVRKAAEKAAAKAMKVWEKSVKDYEKTVKDWEKACEKNERKKREKAKKEEKKSTAQHDGEVERLRREKERMEREERRLKGIPEPPVYNAAEQSTAPLQGSVLLPSPSNSPSPSPTPSPTQSPTPTPEGARKKKRERKFCLTPRTPDPCWIKVEMTGVDEVGAHCGLFFLGDVYERLVGDVAGRIEGWVGEEGTRRVLGGEGGSGMENGFSSSSWEGRVAGRVELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGS4</accession>
    <name>A0A2T6ZGS4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ZPR1 zinc-finger domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1196073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000283">
        <property type="protein sequence ID" value="PUU74656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGS4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGS4"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="56"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="266"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="480" mass="53811" checksum="04ADA0701FC8B8DF" modified="2018-07-18" version="1">MTFRASMAAPVGQKQDLFQDIGATVESVAGGATEQAGNDEDQTNIEEPQVVDNIESLCMNCHEQGMTRLLLTRIPFFREVVIMSFDCPHCHFRSNEIQSAGVIQERGCTYTFKVESKLDLDRQLVKSETCTAKFVELDLEIPAQRGQLTNIEGLLSLVLEDLAGDQPVRKSLQPEAYEKIEEFIKKGREMLDGNSFPFSIKLDDPAGNSWVEPKPDDARNKWIRQDYVRTPEQNAALGLADTTGDQTREEEDEDAIRPDEVHTFPASCPSCARPCSTHMKLVEIPHFKEVVIMSTVCDDCGYKSNEVKTGGAVPSKGRIITLKVEDEDDLARDILKSETCALQCPELNLDLTPGTLGGRFTTLEGLLTQVYDDLHQRIWGDVHGESSDSLDKQTKDRWEEFFVGLEDAKSGRRKFTCILDDPLAASYVQNLYAPDPDPQLTIVDVERTKEQEDDLGISDMVTEGYEEKEAEKQKEREAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHY0</accession>
    <name>A0A2T6ZHY0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_996237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000251">
        <property type="protein sequence ID" value="PUU75100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHY0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHY0"/>
    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="2">
        <location>
            <begin position="40"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="316" mass="35660" checksum="094D7D62FE2ECADA" modified="2018-07-18" version="1" fragment="single">GWESEEAERHFNRQRVTADSSANNKRTQQGFFKRMLEIAEEINHAANIFPSQAGQRVLDVCMAPGAFTDYALRKNPRCIVDGITLPVESGGHEVLVRTSGRHNLTISFTDLTLHTIYLPPGMSTPEHFPDRQAFAANPQLPQMYSPYELVICDGQRLRTHQQAEHRSWEPGRLLLSQLILALTNIRPGGTMLVLLHRVEQWNTVSLLYRFSQFADINLFKPKSAHATRSSFYLIATRVRPDKAAPWVSHLRHCWARMTFGGEEGRGMPLDGAEDLEVDDVLRAFGARLISLGQEIWETQRDALNSSKWIRGSGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI61</accession>
    <name>A0A2T6ZI61_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tyrosinase</fullName>
            <ecNumber evidence="2">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_995856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI61"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI61"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="9">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU75187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="604" mass="68987" checksum="38CB95CED3179712" modified="2018-07-18" version="1">MDLRELATRVQGPETKKPTWDDHIAGLFTKPFWIPEGTTRDRVTARWIEAMKGYMMDLESYESVKQWAVTTYYHLRGRSMPLPGELGEQEYFPKEACELIRLWINQGMRKTTDDEIELREEEIEDIDESEWEIPRVRKDILELTQEELDYYRMQLDDVLRAGDPDSSSPWQKLGSIHTEWCLHYQEAFLPWHRAHLLYMESLITCPIPYWNFFAKGADEYGNPSAGIPQAFLDEEYKHPLTGLMRPNPLKYACANSGMSKAAMSPGYRGEFKDTNSKKYIQRDPRLTGGGTEEERREKISKVKLYQDQILNALTWPIFSQPQGLYGYPWANIQSFDPPPSDDEYPNREDFDGLFEQPHDNFHGWIGPDMADNSYTAFDPIFWSYHANVDRIFEQYIHDHQDATFSSIFPLQPFTGARADKMSLGDPRKHIYTTIGDMAKTSLALGYSIAPPVHQDCPPNPVLYGREGPTAGSKTPYVLFQGVKCTTESYTIDVYIDCPESRRQASVSNKHYVGRLTRMGMGASASKGRCIKKGVTRVLNAAGAAECLSIRDDAEPVLSQVVTDIKTGETVPEEVYKQWDGFVGKLVWGAAMPQGKGRRVEKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI67</accession>
    <name>A0A2T6ZI67_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_366739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI67"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI67"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000016">
        <property type="entry name" value="Cysteine synthase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="169" mass="18457" checksum="3E618106DCB6E80B" modified="2018-07-18" version="1">MMRYLGFMEIDARDHWRHWMTISFLEPGGSVKDRVAMKLMETAEAGGLLTPHSGDKVYEGTVGSTGVSLAILCRARGYLAHICMPNDQATEKSDLTKLGAEVEHVPPAPIADRAQFVNKARARSEEHTNSPSIPGRGFFADQFENEANSVASAVWPGPLANLNMEALDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI69</accession>
    <name>A0A2T6ZI69_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1090944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI69"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI69"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="228"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="402" mass="42981" checksum="35C95525E7A15959" modified="2018-07-18" version="1">MNGMQCQLKPRATQATAGNDWSAVFVHAGAGYHSVPNEPAHREACASACRAAMAFLKNGGSATDGVEMALKSLEDNEITNSGYGSNLTIDGTVECDASIMEDSGRSGAVGAVWAFKNPSALARLLLDNTRQPLSLKRVPPILLVGHGALDYAKEHLFPEVDNEALITSHTHARWSRWRRELDIAEQEEQAADRCQRVCRLPTSAAKAAVEKVAANAPRQPDREDLVTDTVGCICVDRWGNVAAGSSSGGIGMKHRGRIGPAALIGVGTWIACEGQSVVAATCSGTGEQMAHTLIASKTVSRMIATEDEIEALKKSIEEDFMGSRIVKESTMSSAVGIMAVKIDKASPRARIKFLYGHTTDSMVMAHMTPFMKDPETIMSRNRKNPETCLGGKSIQASKLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZII2</accession>
    <name>A0A2T6ZII2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1090763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZII2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZII2"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="136"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="PWI" evidence="4">
        <location>
            <begin position="660"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="83979" checksum="FF40CA9EE40515CC" modified="2018-07-18" version="1">MYPYGQHFGRPTMPPGFPGIPGVSGMGMPPGFCMPPGTGPPGAPGLPPPPGVSGAPPGTAQANMPTRPGMPGFVPPANLPNINFNAPIIRLGTSVTRQNPVPSSSSTSKSGAGSSQSFSRDAAADLAPPSVEEQLKTVFVGSIPRDLDDEWLERILKSVAPLKKWTRATNEKGELCKFGFAEYEDPEGLGCAIEILQDLEVPAIDEHSEPKKLMVVIDDNSVTYIENCEERVDPQQLKNRRESARAALATTLTEYKDPSKRAPKTTEGSKTPAPEKTSETPAPDSVDAAPQPEIVTIPLSADDELSDIPADMRDMVAKEIAAFRERSNRRDLERLKREEEIEKMERDRNHGPRVNRLASSPPPLAPTGPSGGANAIPIGPSRLRDHSGAPGASTKIPTGPSSGSQLPRDYHKGVAFVNGGTNGLSYSKEEEDSDASDEELEKRRKAKKKADQEKTFLDHERRWLNRERARTSALEREQARDLEDEEREKMDNIAMGKRLAEWDDDVEAEKKIEEYYVDRSMWIRNRAAFRNREIEMDERDRQAEARQAEMDIDKKRAAESMADSFLARQAEEMEKAAQIKEPQKFKLALGAAASKKQEQQGPRRKTAAEVEGMLEDEEEDESKTKRVLVPIQYDSTSVMDEETREKLVRQLAQEIPSDRKGLFEWKLQWDHIDEAILNEKLQPFVEKKIVEYLGVQEQELINFVLEHIRKRGTAEDLVKELEMALDEDAETLVKKVWRMVIFYSESEKRGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIK1</accession>
    <name>A0A2T6ZIK1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000240">
        <property type="protein sequence ID" value="PUU75244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIK1"/>
    <dbReference type="OrthoDB" id="2959714at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="279" mass="32094" checksum="1E24400B7D8435AC" modified="2018-07-18" version="1">MAQAWTQSVASLESVFAVLSAHDHPFVMVGTYALRWMGVQLLPGYIMDILIRTSQVASICQAFPQTGEWLEVDESSIPGLATLSEREECRSVQRFKRCDDQWYISLCSENTYRLTVDSEKIQVPYPINFNSALVQSEFHPNPGDRSSDWKTRPYLMTDKDIAFVWPASGQVSFPVFIPTIPEFLDSCLYCIGGRNYRDYDDCDIPHGDMSYLARYILLDLPHQQDKLLSKVKNAKWLAEFFADRQWRQERRMRLVMERQVKSAANSKPGPQVPFATLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIM8</accession>
    <name>A0A2T6ZIM8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_355637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIM8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIM8"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="224" mass="24683" checksum="C23457BA17831FA8" modified="2018-07-18" version="1">MEGVKTKSGRKVHRPAHFNPAQKQPSRRRGPYRRIHDARICKICQRGHSPQSNMIVFCDGCNTPYHQLCHDPPIDDLVIAVAEAEWFCASCSKKREERPLSTGLSGQNLTEDEKRTYLASLPLSSLVELIFFCERTHPDLPLYDPKTKSIVASIKTTSVAAVGKDGDEETPGVNGDSAPVEVEGGEPATLTGVPNWEDMIVRAIATIGDEKGSQAKAIFEWLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ32</accession>
    <name>A0A2T6ZJ32_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1110060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ32"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ32"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="462" mass="52267" checksum="8D7375F8A8B60CD1" modified="2018-07-18" version="1">MDPGLPEKPYNISDKNSFAYVSARDRWPVILTQAVDDVFKHTSNSEDGIRKQEGSKIVAQIAQLKYELQHDRTITPLEDDGGDDIAGYNEELEKLGNPRWFDAPWLFAECYLYRRLNTFFANSKTWKTHDVFRVQKTNAFKSSRAAVLKLASQYRQIVSSLKESKEPTDTRETAETEKEIFTDMSKMCLWGNATDLSLLTTRASKDIQKLQENHSDQVYHVLKKQRDEGKVGRVDIVLDNSGFELFVDLVLGGYLLAAGFATEIIFHPKSLPWFVSDVLLGDFADLINALRDPVSYFDSPGNGYSPGGTEPETPLSDSEKSDLEFLFSEWSELHTQGKFLLRPNRFWTTAASYWRLPSAAPQLFEDLRQSELVIFKGDLNYRKLTADAAWDPTTSFPKAIGELGKVGSGVRILALRTCKADVVVGLGKGKDAELRSGDSEEMKRKWAWSGKWAVIQFWDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJC3</accession>
    <name>A0A2T6ZJC3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_896141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJC3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJC3"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="280" mass="31755" checksum="5A453B151606E519" modified="2018-07-18" version="1" fragment="single">EIIISVMGVTDAGKSYFIREVTGNPEVKVSGGLYSSTSKVQPYSFEYLGERITLVDTPSFNDTNRSDTELLKEITDWTSATYKKNQLLSGIIYLHPITQTRIEGSTMSNLRMFQSLCGQEVLENVLLTTTQWSKVDPEDGQAREDNLRDEGLWGGFIGKGATLQRFHGTKESGLELINQLVSKKRKPLHIQDQIVKQHMTLLETDAGKLLNEELAAQEKRCRRELESLERQLREAIEAKDSEMNQILTAEQARAQEKLEKIAAEQRWLEGSHAAEIEKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJW5</accession>
    <name>A0A2T6ZJW5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_312094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJW5"/>
    <dbReference type="OrthoDB" id="5419888at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="15294" checksum="B091423541C1278B" modified="2018-07-18" version="1">MFRNRQSSQKPPDELFERFRQSFPGVRAGSTSGPSESHLQTAGGLHDSTLNQPRQVPCRILEARVLVSLLLCTSSDGDSMLHIVWEGVGGGSSFSCPLYQLVSFFFFLRGKSSHNLRKGIEMKLSGHPADDPFCLDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKG5</accession>
    <name>A0A2T6ZKG5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_992403</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKG5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKG5"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="108"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU75946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="470" mass="50747" checksum="55289AF63D710F67" modified="2018-07-18" version="1">MADSDEDYIATDDEEIGAHNVGKGGRHRGAGGAAAAAGRSGARSKNGNKSGGGAQKRERWEDIKRSWDNVVEGEDGSLSSTVAGLLEAGKRKRLLKDTTPLQRGIIRHLILILDLSSAMMEKDFRPTRYLVSLRYACDFVREYFEQNPISQLGVLGMRDGLAVRVSDLSGNPVDHIEAIGKLRLDEGKGAPSLQNALEMSRAALFHAPSHGTREVVIVFGALLSSDPGDIHQTINHLVEDKIRVSVVGLSAQVAVCRELCKRTNAGDESVYGVALDDKHFRELLLDTTVPPVTRSAKMSASSLLMMGFPSRMVEKTASLCACHSALTKGGYLCSRCSTKVCALPMECPACGLTLILSTHLARSYHHLFPLKNWVEVPWKAASKSTHCYACQIPFPHPPTKPEELSAPAKTATGTSVSSRYACTICHNHFCIDCDVFCHETLYNCPACQSSVPKGKVSNGAGGRGDPMEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKV0</accession>
    <name>A0A2T6ZKV0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_992108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000205">
        <property type="protein sequence ID" value="PUU76044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKV0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKV0"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="258"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="497"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="665" mass="72025" checksum="39D728EA59F38033" modified="2018-07-18" version="1">MSPQPVQLPPQKVIEKAGVRILCIANVSGNLRSLNELAMKAKADHILHTGNFGFYDDSSLERIADKTLRHVAQYSPLLEDGLKKRIQNSGPSSQSIKQLFGQVEHPLSELPLFLNKKCTLDVPVYTVCGVCEDVRVLEKFRSGEYKINNLHIIDEASSRLLDVGGVKLRLLGLGGAVVMHRLFDKGEGRTTIAGGQGTVWATLLQLGELVDTANRVYDPTETRIFVTHASPARVGLLNQLSVTLKADFSISAGLNFRYGTSYNEFSLNPTLDHYRGMLASSKASFNDVWESVKGEVLPTLLQNEAQQGFLNNVLDIVEQMPTSANGGNPFGGPAPNTAPGTGQVDESAFKNMRNFDLADAASGWLVLEVEGGSIATEMRARGFNFAHKSGQGAPTTQQQQQQQQPTPLPAQAGPPVTPKPPATPRPVPSGPANSTATPVATPLRIAAAEKPSTSNRTRTESPVFRVVPKIDTPAMALVAAPTRPQHQEASSTQDRLQPPGLYVTGVKTVDAVRALFPSEVQRKIQRIEKRHPRGRPHFFVYFESCEVAREVIEQLPEDFKTTPPLGEYKVLVQLMENFSPSSNSRPGMSGSKWARGTGTDRGNTSESDNSTGSKNRGGYRDCGRGSYGLDRGGGLRGRGSDSIIIQVGEGCTGGSLLGHVWRYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLA3</accession>
    <name>A0A2T6ZLA3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1052376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLA3"/>
    <dbReference type="OrthoDB" id="5418222at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="681" mass="73100" checksum="AA3959A3DF49A3FF" modified="2018-07-18" version="1">MTSIKFVNTQALRGSHQLQYAKPNTSPIIPTSSSLPNIASSSINSRPFDLEHQMRVFMVEKRSHGNQQQHNPAPASAPFPAPPPRKYVKSSKSKPWFIAPPPGGRGLPPAIATSATYYAASGRVVTRTELRPVHRGSPTLSHKSSSSTSSSPVEAPSAHDRSRSKNNITDNTWGVRPVPSAAPPTALQGLDGTLWVAPSPSNSPKSSPNPRPLTHIESPLLPPPPSTALLGRSGSLTRRTNSDLRIVPPPLTTTGVAGKTGYPPPPVSPPMPKPRSSPGRARKSPASRTSDVLDTVYSMYNKLPTSRDRRNSDGGERDFVSRLATKIVPRRNTPSPSPPQPIPQPQIAQLPPPPPPPPKPRLGNASPPVIPLVELPGTIPLTPPQSRSPARRRSPRPRSPRDPGSPHSPPPSPESQEVYSKLPLPAIPTPTPTKPLSSNEPSPLPQLSPLSNPPTGPTLRKTGNFDVDLGYAVELVEWFENFCYPCESASTATTFSPQTPNPPSAKKSTTKTTTTDATVVILSDEESPVSGRQQFTNPQPLPEVGHNLSPDFLSPFKIHNSGMCFPKRKPVPMSMYSTASSVGDAFRFDCEDLSPISDGGSTSGEDDEGDEDVVVVNGEGERLQAQIEDILDSAVHLEGAAEVEREGGIEGEEEWRRTRYIAGRNSALEGDVIFCLKACEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLC4</accession>
    <name>A0A2T6ZLC4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_261411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLC4"/>
    <dbReference type="OrthoDB" id="5343018at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="840" mass="90017" checksum="212EFE0370A20843" modified="2018-07-18" version="1">MSTTEAPTLQNRRLRLRNARTNPSTLPLSSSCYTHKGMVASPISRKSSFPEDNGWETEDQGGDKEEEGSSGGDDDNSDEADRKRRNRVSTSSLLSDGSTLIGGEMDDGDDQEGGEDEVKDTMGESGRRNSNGGSPSPLFSLVGPVRAMTNPIPVRPMSMISTPSPLSYASPTTHRRNRSNGGLGRGDSPGSSARYIDYLERQIADTVSQLQSYTSPSEGTSHAVKMRKLTAETRLLRSELTDWENKFSARVKEEVNARAAIDKSLRTKIKSLEAKLEEAEYRYKTAEVDLEEARATISDLKGVEEENRALEFRIEALSELLADSTRLAQSASVGGSGSSSAASSRPGSVVFPKRSSSLESSSSAPSPTTSLRTQLRYAAVVTTTGGKNTPVEGRSRRVSREGSTCALEDYGITDPIEAVLCSMSQLAETEEEGVEGEFRYPEEYEAELNPNTALIQTSPHPPPAILRNRRMRRFPSGSSAPKILILPSAAVVTATTTTTTTITSPTFPATSDTTSGIFAPFSRPPSSSSSSSSCCAPPPQLLKAATPQNSLFAELARAQDSSEDSEEEEEEDTEAELDEDNNVAAAASISEGLTNPTPLVVKTISKVGESFISPQGTFFRAKRKAMDILGGVVGNRVSRPYHHHHLLPSSKPPSSLSLSPRRPTRKVLNEKNQRNKSPPTTATTCAYCHCHQQPPSSTAITAPPKAVAQTRPRSTSAPLVLPQPVEEAVEHVWLWVRFVVALVVALGVAVREGPGVIVAVDGVGSIGGSAASSISSNSVGDAGGFDGVGEEERCFAIRKLQQQGAAASGRGVVESRGRRGRRGLGWGEDRVRVWERPGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLG4</accession>
    <name>A0A2T6ZLG4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1052175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLG4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLG4"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025091481" description="Carbonic anhydrase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="11">
        <location>
            <begin position="42"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="347" mass="36242" checksum="530BECE594EA09A3" modified="2018-07-18" version="1">MYTQQLVFIAAALSAPLLSSANCMYGTSLFPRAAGAATVEVSNFGYTGLQGPLNWAGLSAENSACATSKVQSPINIDSTIQLAAEAPKVVIPDVKAAEFENLGTTVEVIVNGTTTLGGTNFSLKQFHFHTPSEHRVAEEYFPLEIHMVHEAADGSGAIAVIALTFQLSEDGTTTTELLTAVTENLAQIATPGTVTETGPLKFAEVINHVQTTPLFQYAGSLTTPPCAEGLTFLVTKNPLPLSVKTYNQIKAVVKFNSRYTQNSLGQENLIGVGATALTSAGGAAAGNGTAAGNSTNVAKPKPSNGTATSKPTPTTTGNVAVKVEGEHHCILGACSEIPKVKRFYRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLU3</accession>
    <name>A0A2T6ZLU3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1149392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000188">
        <property type="protein sequence ID" value="PUU76458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLU3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLU3"/>
    <dbReference type="OrthoDB" id="4507199at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="630"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="67"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="743" mass="82609" checksum="390796DCE7D6CE78" modified="2018-07-18" version="1">MSNFRTRLPKWTAISLGDSNHYRRQDGGGRRGNISSSIELSPLDPEFARGEPNPSSSAWKPVWYTGWHTGVLACATSVVVVLLINVGLTIHAATNPKYKMEGGIGTLYSGNCDLSRAIGLWLHLGINALSTVLLSGSNYTQQCLAAPTRSEIDTAHARIRWMDIGVPSVRNLFRIKAERTLLWIAIGITSIPLHLLYNSAVYTSLVVNYPRIVIVTKNHFEPGAYTNTSSPVFSFPEPDIPSTTTGEKDSDYQLFYSMLEGRNTGTGRYEDLTPSQCAKRYSTDFLSTNRNLFLITSHASNATHNDTFLDSIDFWLNDISPSRWMCGHNPEGESQSGDQCNPNELASNVTKGLPWQMDRTAGLIEISGCKSERTAEKCKVQFSLRIMIAVVCCNLVTACSIIIAVVRSREPTLVTLGDAIDSFLRIPDQTTMGICYANRRFIEKEWAWRMRTGPREWNQKEVQRWWSSVSKTRWITSTCFCSITIIAAGVLLRLGIRHDAYLFKTDIISMWSRGLGKVNSVSLLTIGFRKITQSILLVNFPQTILSFLYLTYNSLFTCMLAGHEWSLFSHHHRTLRVTSPRPGQRSTYWLQIPYTYAIPLMTTSSLLHWLASQSIFFVRVEFPNQFGEDFSIVMCSVGYSCIAIIFVLAMGVLAFLAALGMGYKKLSADITTVGCCSAAISAACHAWGADSEDIVGRKVRWGDVGMVSNLGARHLTFSSKEDVSKPVFGEAYAGAVRVECGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLU7</accession>
    <name>A0A2T6ZLU7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_990518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000188">
        <property type="protein sequence ID" value="PUU76460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLU7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLU7"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="579" mass="64908" checksum="5E56D340A2488C66" modified="2018-07-18" version="1">MDIGVPSVRNLFRIKAERRILWIAIGVTSIPLHLLYNSAVYISLAANDFYIFTVTNNHFEPGAYTNTSSHAFSEFNWATPNATTGEEYAEVQLFKSMLEGRNTGTGRYEDLTPSQCAKRYNTDFLLTNRNLFLVTSHASNAAHNDTLLARIYFEQDDPLPSDWLCRYDPVVVSRDDYQCNPNELASNVTRGLPWQMDLSYVGVIEISGCKSERAAEKCKVQFSLRIMIAVICCNLVKVCAMIMTVVRSREPTLVTLGDAVDSFLRISDPTTRGICFADRRFINREWRRGLGTGPRQWKQNGVQRWWTSVSKTRWITCNFCFAIIMIVAAVLLRLGIRHDGTVLNTDLKSMWSRGLGQVNSVSLLGIGLRNITESILLANLPQAILSFLYLTYNSLFTCMLSGHEWSLFSHHHRTLRVTSPRPGQRSTYWLQIPYTYAIPLMTLSGLLHWLTSQSIFLARVEIYDAFGTEISRTISTVGYSCIAIISVLTLGIFALLAAAGMGYKRFPAEITTVGCCSAAISAACHTWGADSEEIVGKKVRWGDVGVVPNLGVRHLTFSSEEIRKPVFGEVYSGAGRERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLV1</accession>
    <name>A0A2T6ZLV1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proteasome regulatory subunit C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1052133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLV1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLV1"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="327"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="581" mass="64910" checksum="B00ABD3EB4B9F00A" modified="2018-07-18" version="1">MVDKSSLRSNKRSDSGSSGNKKNGDSSKQPAKSSAKKATTSKKAGSSSSSKEEILPVENGAEDIEMKDDAGATTPTAGKKTERSEKPGDEDADMNDGKEEGDKKEEDPVVTAINEIKENFTLLERAVTLFDARFTLRVLRSLSSLRRRLNPEILSKIVAETYPGDHPSSRRLTTAIGSSATGMELDSPSEGPKDGGALLPEIDIYLHLLVQIYLLDQKNLEMGASFSTELVQIIHSLNRRTLDSLAAKVYFYYSRVHELLPPPAITEIRPQLLASLRTATLRKDIDTQATLITLLLRNYLLTSHITQADHLVSKTLFPESAANNLIARYQYYLGRIRAIQLDYTAAHNELVGAIRKAPQTAAAAGFVQAANKLNIIVELLMGDIPERSIFREPRLEKSLHAYFLLVQAVRIGELDSFFDTLNTHAETFKKDGTYSLILRLRQNVIKTGIRMMSLSYSKISLRDICVRLRLDSEESAEYIVAKAIRDGVIEATLNHEKGYMQSKELLDVYATQEPQEAFHERIMFCMSLHNDSVKAMRFPMNQHRLELKNAQEARERERELAKEIQDGDIDDDDAGGEFEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM31</accession>
    <name>A0A2T6ZM31_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pseudouridine synthase</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1149115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000184">
        <property type="protein sequence ID" value="PUU76550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM31"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM31"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="192"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="452" mass="50939" checksum="7392C7462414A0D6" modified="2018-07-18" version="1">MHTKIKLLIALRELIRVSQRKCVMDTTLSKSSADLSPTILGSKEEVGLGPSSTSSSPSSEMGEGQSTGGKLSVSMDARKDDTSKPSKVVNPPPVPQYSFEDGLRRVPPYQFSYNTYCKERWRGKPVLEVFSTEFRDRPLEYYGGAHLAPLQTIVASLDSKLENGDMLVHTLHRHEPPVTAKSIERVYEDDRLIVINKPAGVPVHPAGRYNFNTVIEIMKHDCDGRAPLPCNRLDRLTSGLMFMAKTPEAANDFMGQLQTRTIKKQYVARVKGEFPSEEVTCDQPILSVSPKLGLNRVRTSGKTAKTLFRRIRYNPEKNYSIVECHPFTGRTHQIRVHLQFLGHPITNDPIYCNRNVWGPALGKGGEGEDEEIIAKLNKVGREEEIRYDEIIEDYEGRKAEKLTGKRCEVCDTELFSDPGPHELGIYLHAKRYECEDGQWGYETELPEWATGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMZ8</accession>
    <name>A0A2T6ZMZ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1129099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMZ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMZ8"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="60"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="436"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="61425" checksum="0D59314F1DE1ECFA" modified="2018-07-18" version="1">MASPQPPAAPTNGSYPQQANPQSFSTNLTPASPTGGYQSQTTSLHSENNTGNSDVPKDEVGWYFVEQYYTTLNKTPERLHLFYNKTSSFVWGTEGENLQLAHGRTAIQDKITSYEFNDCKVRVSNVDAQSSADGGIVIQVLGEMSNNGLPNRKFSQTFFLAKQPNGYYVLNDIFRYLKDDEDTEEGEYDEYTAEEIAGDAEVAEAITEEVIEAAEDMSLKETTTTEVEVEVQENKVTVEETAIIEPALPIPETQGLPPPVNGSANGSSVETLEEEPEAEVQPDPEPEPEPKAEEPAVPPVEAVAEEPAPPVIEEKKPSPAPGKEPEPRAVTPIPATPPVPAGPPKPTTWAIVAKSANTGAPPAVPQSVTPPQVLQAQQTQPPQAQNSTAPAASSTASSATPSTPTTPRGSSQWHITESKRYSRPAPVSANASAGQTSAYVRNVTEGVSDRALEEALSKFGLSGRVEIIRAKNCAFVEFVSSAAFTEANASNPHKIGDATVFVEERRPRGSASGPGYSGGRGPFGNRDSRTGGQGGRGFSSRDGTRNEGGRGGRGGARGNYNQARGGAASRPGSSTPTTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN68</accession>
    <name>A0A2T6ZN68_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1028007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN68"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN68"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="183" mass="20690" checksum="E58F9FDF38B4C5AD" modified="2018-07-18" version="1">MSGFFRRIYDWLLRMFWATEMDVTMIGLQNAGKTSLLRVLAGGEFTYDSIPTVGFNMKRVQKGHVTLKCWDLGGQPRFRSMWERYCRGVSAIVFIVDSADTSSLPIAKDELHSLLQKPMLNGIPLLVLGNKSDLPDKISVDELIEAMDLKDITNREVSCYAISAKEETNLDAVLQWLIGRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNC5</accession>
    <name>A0A2T6ZNC5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1087150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNC5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNC5"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="233" mass="25971" checksum="1229F2C6E6042F46" modified="2018-07-18" version="1">MSAPKYQPYAPSPYSYTPSPHSLSTSISLDEEVKLSTTVQQRELNESLAEIYSIIVTLDFLEKAYIKDSISQETYTPTCLRLLGQYKTILKNPDVASAFKDLGTFKSAYNLSYPSATERLKIGVPATFEHAPTTSSAISARAAAEATQNFITFMDALRLRYTAKDQLHPLLSDVITAVNNVAGAKEFEGRQSIVQWLIILNRMGAGDEITEAQGRQMLFDIENAYSEFYKNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNH4</accession>
    <name>A0A2T6ZNH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNH4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="115" mass="12794" checksum="270D6F27200B3987" modified="2018-07-18" version="1">MISIHPSSLSLILNNFAPHPPKPTDQPIPGNFPSPIDLSKSHHPFAQAPPPSHTYPSAIHPFIQAEKEGRRKKGRKEGRGKAKGENQRLYSNKEVVEISRLLSPCTPFSKNIHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP16</accession>
    <name>A0A2T6ZP16_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_951437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000158">
        <property type="protein sequence ID" value="PUU77231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP16"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP16"/>
    <dbReference type="OrthoDB" id="4435916at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="83" mass="9204" checksum="80700340F780FFAF" modified="2018-07-18" version="1" fragment="single">DQDGDTPLHEAARSGHSSMLRALIKELRVQRVCSNEINKTNHCGNTPLHLAFQFDHPEIVDLLIKEGADLTIMNNAQLTASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP90</accession>
    <name>A0A2T6ZP90_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1128505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP90"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP90"/>
    <dbReference type="OrthoDB" id="5414761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="39938" checksum="D023FD394A401C20" modified="2018-07-18" version="1">MSEQLGIGYLQEATDSKAKKIVGVASGFYYGDNDRTIVPFVVCYQGLALWVPFLVDSGCPRTYLSPHASAALKLESGTQWWIMIGGHATRTWIAPTGPRFTDLNILGSDFCKKHNVVKGEDYLRGMVKNRITLIKMFRFPSRLAFQDLSKPLLRFIHHTPAPDISSPTYNSVLKRLNSVADQQMFHKRQPPQEVKSDAFDALFPDIKHETLDTIISEEIGIPYLSSAAEAEAKKVIRVAQGYIHGRHCRTIFPLAVTHKDEARWVFFIVGSLCPLTYLSHQTSKVLGIQPDTVRSVVSIGGHLSPAYKASIRSHICGINLLGTDFFTLHGVSAIDIYSKRRAILYFGGNQPMAQVSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPE4</accession>
    <name>A0A2T6ZPE4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1086484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPE4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPE4"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="326" mass="33872" checksum="F5C58CB249FF7956" modified="2018-07-18" version="1">MLALKRLSASRIASVARGYSTSSGYASTAKNLLINADTKVIFQGFTGKQGTFHAQQAIEYGTNVVGGINPKKAGSRHLDRPVFGTVRDAISEVGADASAIFVPPPVAAKSIEEAIEAGIKLVVCITEGIPQNDMVRVVDMLKSQNKTRLVGPNCPGIISPGQCKIGIMPGFIHKRGRIGIVSRSGTLTYEAVNQTTLVGLGQSLVIGIGGDPFSGTSFTDALSVFLEDDETDGIIMIGEIGGSAEEDAADYLKANNTKNKPIVSFIAGISAPPGRRMGHAGAIVSGGKGGAESKISALEGAGAIVERSPASLGKSLYEQFVKRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPY5</accession>
    <name>A0A2T6ZPY5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable kinetochore protein NUF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1086215</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000151">
        <property type="protein sequence ID" value="PUU77494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPY5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPY5"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041112">
        <property type="entry name" value="Nuf2_DHR10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18595">
        <property type="entry name" value="Nuf2_DHR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="16">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Nuf2 DHR10-like" evidence="17">
        <location>
            <begin position="287"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="327"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF18595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU77494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="468" mass="54524" checksum="EEB3E988555D56B1" modified="2018-07-18" version="1">MAYNMRQSNFRGSQSNSKPPGSTMKGKQQQQQYAAENHLLLKDNELVDCISELGIPFQMEDLKKPSPQKIQLVFEMFADLLMGVRKETVEPVLNAAAQQVLEFPETQTDSHTLMAFYVSLSQLMLECGIEDFTFNDLAKPDSMRLTRILSYVINFTRFREERANIIDEHFGKAQKAKEKIEQLYFENEDLNNRLQELKMQRLKEEPMIEKAKEVRIALVADLETLKKRQDALVNDWGRLQQSKASHKQTLEDRHYLKVKTQQENNKIRPYIVDSPQKLQQVITDMANSLGTEKAAHDSLERKSRSLQTSADSFVIVEQDVTGCIKVMEEVEQELIKEEETSRRVSRHTETLTAKQTEVHDVERSEKRLSRQLKIATEKLERTRKTGEVKAEAAQRRMLELKKEYGVLSHERSERDKEMEYKKVCIERIEKEMVDMKETVETEVAAAHKEFAKMKSHVELYIDEMEKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQJ4</accession>
    <name>A0A2T6ZQJ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1026574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQJ4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="66" mass="7234" checksum="1A94F406B3A5EACF" modified="2018-07-18" version="1" fragment="single">YASGTVVISNKNLPAFSFSFSLPPLLLPLLLLVLPFLLHFLLLPIIVPELATRQSQSVATERGVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR47</accession>
    <name>A0A2T6ZR47_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000134">
        <property type="protein sequence ID" value="PUU77961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR47"/>
    <dbReference type="OrthoDB" id="10449017at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015687844" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11621" checksum="8A1E3B35854E5ADE" modified="2018-07-18" version="1">MTITSHFTFLFATFLLLTSTLAVPADTAIPIIKAPEVTIVSPYLTQLMQSIPLLPSPENATALAASRKLIQEAIVAFNLNYGDLPNLGEKEVTPNHHLICETTEMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRI3</accession>
    <name>A0A2T6ZRI3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_117085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRI3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="21836" checksum="3AFCCF159DA8BE68" modified="2018-07-18" version="1">MLRRVGYRERDTGRPDPRGERYCTVPAQRRYFTVRKESHTFLSLLPLPRLKSSYPPPPPLPHLTYLYLLPFFYLLSRAPFPALGVQYRFFYPTVARPRFICASAPTIKSLFSQRQGRALVRSPTAGKRLVPRKSHIGRAVATLRIMSTHAVSLRICWRTTRFFSSRFEPFSHFVITRFPPGTDYGGGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRW2</accession>
    <name>A0A2T6ZRW2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1127161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRW2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRW2"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="32280" checksum="B97C7F0B70D69EB9" modified="2018-07-18" version="1">MKTGVDTMLSRTGNTSFQTTSLNKKDIMHHIYLLLLDGKLVRAPVGDGIQRILDIGTGTGIWAIDAAETYPSSQVIGTDLSPIQPSWVPPNVSFQIDDAESDWTFAGDSFDLIHIRHLNGGIKNWGKLIKQSFDPLKPGGWLDVAEYECRLRCDDGTLPVDSSLHRYYDLVNEAADKLGQEFKVAASLDSFILDAGFDKMSHEEMKISIGTWPADKKQKDMGAVMLLAIEHGFESFGMAFFTRILGMEVPEAKELIAGAKKESRSKKIHSYGVQHLYSGMVIKGGKLSVAKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSF2</accession>
    <name>A0A2T6ZSF2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSF2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12178" checksum="1522C7C8C0045ADE" modified="2018-07-18" version="1">MAVVGRGQLRGSKNLGGQTTHTGIITIACGYGGDYCCSYRLLLLDSKGHRLAHPSLGDSEESGNNGQNTPWLIFFNIIIKHPRDFPWASSAMAQRLHGDHLVLAAANILGYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSR5</accession>
    <name>A0A2T6ZSR5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1048347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSR5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSR5"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="422" mass="47321" checksum="9B01A5CAD832B232" modified="2018-07-18" version="1">MEKSISVLSLRPSDLRGRRQARKNYILRIFFVLLAGLTSLGGFHLRDNIHGCRKSYWSIEKRVEHILRSTPLIDGHNDLPGKIRDLFGNMIYNSNFTFDTSLPGQVDLPRLKKGRVGGTFWSVFVPCPDTKETDDEVYYLIVQATLQQIDLVHRLAGVYPDLALTSSPLAVRHVHYHGKIASVMGAEGLHQIGNSASNLRLYHSLGVRYVTLTHNCNNKYADSALPANDTLWGGLSDDGKDIVKEMNRLGMIVDLSHTSHDTQMDTFKVTGAPVIYSHSSAYALCDHPRNVKDEALEKVKENNGVVMVNFYPMFVKRDGGEARLGDVADHVEYIGKKIGWEHVGIGSDFDGIGMVPVGLEDVSKFPKLLEELLRRGVTDRQASLIAGENILRVWRDVEKVSRKMNREGVKPLEDRVHESSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT18</accession>
    <name>A0A2T6ZT18_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_56304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000113">
        <property type="protein sequence ID" value="PUU78625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT18"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17189" checksum="7CBBE2795942B075" modified="2018-07-18" version="1">MGGFLIAHFAFFEPPCVGPCNNSQETQSPYPLPAPFLPPLFPLYILSYGQLSSVVSTTTIFVSPARRLSSLSNASTLPSNHYKSSCLTPPPLILPPRTLLPIPTRQTLINNAHEEAWHETLERLEGRIIGFLGDTWDVCRQNFSLIFVFHGSCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT33</accession>
    <name>A0A2T6ZT33_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1126362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000111">
        <property type="protein sequence ID" value="PUU78652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT33"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT33"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="14552" checksum="CF3B603C3B849B3E" modified="2018-07-18" version="1">MAYYRTVHHSVFNKIVPTFSVMGEFILRKYYGPSNAAKTIERHYASFIDEKAFQEMVDVGLDLVLIPFSHWATITLAGDSLVQIIFGRYILQANEYARKRGLRVNLDLYNVPGGANDCNHIGKLRLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTB0</accession>
    <name>A0A2T6ZTB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTB0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="9936" checksum="09356B8986428879" modified="2018-07-18" version="1">MINTTWQKPPNTEPSSLPNLTYLPTTTSHDDTRPTGQTLHSTPLHSIHPSASPFIHPSIKTQARNQKQRHNPAPWSNDSFVRPRYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTE2</accession>
    <name>A0A2T6ZTE2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_36798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTE2"/>
    <dbReference type="OrthoDB" id="5478287at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="315" mass="35324" checksum="C1BB05769BFEABA3" modified="2018-07-18" version="1">MPTGSPTKSFRSSTTQREKGWEAIAKENQRFFLPISPTDSNDRPVLNVKVDFDGRFVGKSLLYLCIEVDIQASELQGERCMGYLDPSAVEIILQERSLIHAVESVARENMREERGPRNASRHPGNLANSGGYPDGHRIRESSFGQNDLGHSSLPLRREFSNGSNTRSAGRPSGASFRYPTRSSGAPTNSPRAPRQVGSLGAHENRGPDGNYINHQSCIPYQNSWSQDRPRPNRSPHHARIRGRAENPPVQNIGFSQTYTIGRSSDPTFIGLAAPVRRSSTEENQWHDPRHYQTKVNKNGSQKRQERLAREKPPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU19</accession>
    <name>A0A2T6ZU19_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU19"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="8113" checksum="5B582262F32E418A" modified="2018-07-18" version="1">MTSTSIPALPSAGIPVSKSGAAENPARNTPLPSAITPASDPVSENGGATSSTGGDGPNGISSKRLPTFKVLEAFRIPCSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUA1</accession>
    <name>A0A2T6ZUA1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1192885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZUA1"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="555"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="617"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1788" mass="200521" checksum="4C8BAB5B8552229F" modified="2018-07-18" version="1">MPSRSKIPLPVTPVPLPERLPELPVPPAKFLHHVQANPGVPVRQLLEPFIEYEAALRAYFAQAPDHQFVKGDVNLVSLFEDGNESLLKIRGRKLDENPEEQERYVMPLSEGSRRSDGEPALVSSLEDFKKNFAIFSEGALTNLDWGHVVAAGSSVLTPLLRVPEESGKSMSVRLLREYYHDTLAPASDIDLFIHGIEDPQGAIEKMAAIENTIRDNLLWETTTVRTKNTITVVSQYPNRHIQIVLRLYKSISQILTGFDVNCACVAYDGTRVLAIPRAIAAAMTQCNDIDLTRRSPSYENRLAKYSLRGFEVYCPFLNRSRIDPTIYERAFNRTVGLARLLVLETLPKPEDRDAYVRQRKEEMGRPVNHYASHWTRNQGNKKLGADEDLAEWNFEDISSYERFSIPYGPSYNAKKIERLFVKRDLLLNAEWNPKNAPPHRTVHLHRHPVFLGTVKGVAVDCCGFCPEPLNDEEKKVQEQEDVIYVRGSLKFLKDDPGRQEIGSFYPLGPEDYTEMAYVGNTERFCQAIVKNDLEFVRSWCSTREGKADINRRDFCGRTPLHLAVLNEGTLIEVVQTLIDTGARLVARIQDGRTALHIAAGKGRVDIITALLKKSEENEHERDFRDKGRRATESSRTREADADSDKDVSESIHSQSDLSGEEFEYMRVGTGSIAAETATDGSYVRVKKGEEEEGLVEGVIDDDEDQDDIYDINVIDWDYQMTPLHHAIVRGHCSTVELLVSDFGADPLMPMKIFGTGMYGGSKTPRAAVLVLALVYLLPREKQAEMAATLLRVGARTSQADSFSKATGLLHAVAHCAMPVLEKMFELDNPGVRSVLNKVSTYNYQDATTPLTVALRGAGSQSLDIANYLLDQGAAGYIRFDDFQRCLKTCYGSFFGNNNDNSYKALKQTIEIAIECEYSCPLIPRLIKAGADPSAITSPTLTRYNFAGPNHTSGETVLDMLRKKIQGYRNSLDTKPEAAVSVWKEEPLPASFLDSFTEGSWERFTAEFAWKRENKARDLRSAGSEQPVIFGVAKAKQREEVEKRLRLFEEAEKVLLEAGAKAFEELYPHATPAQAGQPTTTFGGGPVGPFHLFGSPATQPTFVASFNVSVPCEKDTLERYSKLFDAVWKGDQETVKILTTGPSGEPPMPALQISVSSRGWTTLWIAIYRRDYTMARLILEIVKSQYEEPGKKQAGKAVRINIPGDSDDDYSERYFQDPGDEDFTIEDAGAVSDFVKCGISPYAFICQGPPQLDELLGEEEEASLRKQNLFKWMGGWTILSLSIYKDDSELFEFILSAVEEFGGPKAPEEYILPIYGMQRYSACAHVRLALALGRIWVLEELMKRYTFGIHYDSLREQDHEIQKAKPKYYRGLVVNGIRAQVNNPYETSSPDTKDIQKPLQVAAYFGNLDSIKWLLSDRPWGCLDSFIGRNPENECAKLLRNQGDALPKIFRESLGLDNRNLPHICLLGWAGPDPMEAFRFLVSRPGSLESRTNAGLTPALFAVVQRRIHAIKYLRQEDVAADFSTRDFMGRNALHLTFCDASDHPNLSVSTIEEIVELLPEDKLADMFLQRTRRRGHTPLAHLLHHLLQTSMYGNPKFPVHVVEVLLKYSKGSELGLFDFEGNLPIHTTLRRNMTISARLLLAFKPEHINAENASGRTPLEIATSNYLTKISQNPQTLNLRGHHPSAILYQPSDFLAPGGRAVEVVGGGKIVNEKEGWDTSDVNSAFELACKAAREAGCGRALVSLHEARSLVQRLQGSKDLPITEEEEMVYKRQREVVGQFDPMWAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV52</accession>
    <name>A0A2T6ZV52_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1125392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV52"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV52"/>
    <dbReference type="OrthoDB" id="5382815at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="369" mass="40776" checksum="B7EFB6D5FB180F9E" modified="2018-07-18" version="1">MPRPFKWGEYFNKDTPLLNRSNKYQVTCLKCQKKIPKGRSEDRTRHLIDECPGLSPEERMTVVEIDARDREAAETAAEDRNATGNKIKRPRNPWVKSDFTEAEIAELSRLFGAHHAVETETDWAEVLGEYNLWTQRNGYKKRTLDSLKKQWESRVSNAPGMTAYNYAQDTGKYAWDTDERGTVGVPVIGGLENMGNEDDTDLEASYDPGLVAAAAGPSYPIARASLANRFSGSQPPASTPLLLPPAKRPRGRAVPVTPMTTAAPRPAESPSLVNVLERINEEKAKQIEKLEAKIEKLEEKLEKLDDRNRKLESRSRVLELQLMARKDVTGRATGGGGSGGGKRKRGGSTDLASLAQLEEGDDDGDGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWQ6</accession>
    <name>A0A2T6ZWQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_777746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWQ6"/>
    <dbReference type="OrthoDB" id="10431678at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="40037" checksum="834CD24533EFEB00" modified="2018-07-18" version="1">MNTPVLDCQFRTNQNSHLQSHISKMFGSLKLKGRAKPSSSSQVWTGDEGEVPSSDGYANKKDVSSKSETRPDLSRTPAAPTREYQPRESRYLERTPSGADYTNKRLILESLFDYFTPEDLSSELPLLTLLCEKATKEIQKCNALTLEVKDLKRELARAQSEKYFSEQAIRELALELGLMGPRLGLTESQKILNKDAAAILESGGIPPLDIMLNGWTYIRVGKPGDGWDKYFYNPLEPFPPGRRRYTTGNDSSQMLPSSPKRTTSWKRNGGPARPPLAPQHTSETDGRVSPLVLPRSKRHTWGGNNCFPPGQCTPPQLPTHEGSVTISPSRPTHRHDAASASPGISSRYFNWTPDKKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWZ4</accession>
    <name>A0A2T6ZWZ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquinone biosynthesis protein Coq7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_976922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000076">
        <property type="protein sequence ID" value="PUU80005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWZ4"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0830">Ubiquinone</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="8215" checksum="5950BA573D9CE191" modified="2018-07-18" version="1" fragment="single">NVAGYALGVGTALLGEKAAMAFTEAGETEIGGHYNDQLRTLLDMLKDNLNLLYYSELKEQMNMIREFRDDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWZ6</accession>
    <name>A0A2T6ZWZ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000075">
        <property type="protein sequence ID" value="PUU80011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWZ6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="490" mass="53236" checksum="FE52C0B298BFC7AA" modified="2018-07-18" version="1">MTTDILAVQGASVRLEYVFSMAQEVILYHHSRLQSSTIRVSMPVKFYEYEELQLELAAHADEKKRSTETDNGYISDDDESHQEETVCSLVDQDGTRAFAREPRPMLPDRVLIKSQHARPPPSHSQNQDVDPLIDSEGSGNDGRIWDSAVNMYIAANTEEEEKLAEEEPQISGEEMRDLESIHDGDNLDVGHIEGLAGHQEEIRFKEQGQTDLNATIGVTNSKRSGTGNKVEVFFQNDSYGEWAPPTSRKITLEETQAEMIFVIVAAGLNMIYRDEIGEYVGKAMGWNIVRYASIEQVHAKLGSLTTKDTNMKGHMKKALLSLFKAMGAITTAQRILLTAVALDCLQEYKKILGKCLDHRTSCETDERECEFEVGDFCITELKRRGNQGWNTRAVARGSSGSGGDGTAGTPRSGGTNRSSNAAGAAGTPAADEGGGATGWAAGSAVRDSARSANGGTTGCTVYQGDGVEPSRTGGRGNPLSTPVQWSPTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX23</accession>
    <name>A0A2T6ZX23_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1063777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX23"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX23"/>
    <dbReference type="OrthoDB" id="3780939at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="19311" checksum="914C0BF98223EA47" modified="2018-07-18" version="1">MGLNDSKILGFLTKEGYPLTIKILKRLRLALGMRRCFHPTEFAVHNEIMRQAIQSQLENGQTTLYGRQYTYQILRQCGIPAVRDRMFNILYEVDPIGIANRRLHITNMPRGGYFVPGPNYVWSIDGYHKLSMYGIEIYAGVDAYSRFDTIWLYPWLIPLLYGSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX34</accession>
    <name>A0A2T6ZX34_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-processing protein prp40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1022086</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX34"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX34"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000033">
        <property type="entry name" value="Formin binding protein (FNB3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.440:FF:000013">
        <property type="entry name" value="pre-mRNA-processing protein 40A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25432">
        <property type="entry name" value="FF_PRPF40A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="218"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="365"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="9">
        <location>
            <begin position="502"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="337"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="93451" checksum="D6B19B27F42BDC50" modified="2018-07-18" version="1">MSALWQEAKNPEGRVYYYNVQTKATQWTKPVELMTPAERALQDSPWKQHKTEDGRPYWYHAETRQTTWEMPEAYKAALERSSQSQALSHTPQTFVAGGTQHFNNSYENNERQVAIQGQHGPDSGPGGDNVAKSMALPSSLGNDKEGPQYSTHDEAEAAFIKLLRRSGVAPDWTWEQTMRSIIKEPQYRALKDPKDRKAVFEKYIVELKQQEHEKAKDRITKLRQDFAVMLKSHPEIKYYTRWRTARPMIEGETIFRSSSDETERRQLFDEYIIELRKAEQEREHQHRKEASEELVGLLKSLDLEPYTRWSEAQAIIHQNERFQSEPKFQALSKLDVLNAFENHIKVLERAFNDKRQKMKNMKMRKERKNREAFSALLAQLRSKGEIRVGTKWKHIHPSIKDDERYLNMLGQPGSTPLDLFWDIMEEIERELRLKRNLVMDILDEKRFEIREQTTLEEFSNLLQSDSRTSQYDRETVSALFDRLREKIVKRLEDDRHQHERQQRRRTDALRSAIKHLEPAVEISDTWEQVRPRIQKLEEFQALESEESRRTAFDKYIRRLKEKHDDREKERDRKDRGERVRDKDRDTRSYRGEPELRNGHDSTRSYHKPAASSRHHRDSHPLSRSPEVDSYEAERRRAAGERERQYQHRGSTGRSNSHHRSERGGREESRHGRDRQESVYDRERREREEERERLYRTRGDDEYRARRRPRGLSPAEESEDGRRDSKRSRRERTPRDRTPRERNSRDRTPGNWDARSPPRIKQLVKLTDKVQADKDEESEEGEIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX91</accession>
    <name>A0A2T6ZX91_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1045199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX91"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX91"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="201" mass="22675" checksum="1BA649D906081B50" modified="2018-07-18" version="1">MNTNPPIYFREDDPRYYPFCLSHSCAFTSSSSPIGSSNAALAYCYFTSLTQYLQYRKAQFFYDNRAAEDILATRDVSVIMSISRRINGLQVEVWNGMRSMVVREGLMLKFGQNEELRRLLLDTGDRELVYAAASREWGIGFAPADAGKNRDAWGLNILGQALMEVKRRLREYADATGTYPKARPAPVDIKMNSLVELQGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXK4</accession>
    <name>A0A2T6ZXK4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1123974</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXK4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXK4"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="349"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1096" mass="122893" checksum="D2D6D07E376FB58C" modified="2018-07-18" version="1">MLSSLLRSKKKKRRTEHSPFSSAYDETRSDYFQRQADVDQGDSGDNDDSGNDDDASLESSSIVSSGDEENENNPLLPIFSAAELGMKNLPLLLVPQLFGFDNNGRFVDLIPVYTLVHSIRSDIVSRVDTSLTWDQLRSPQVSSFLVKPILSSLMRGPNRLSKGILYSLMANCLQFSKEAYENPGIASVSKTRALLAEILAIKLLKEFSNRELIDALSYDFYPLQGMPPPTAPEAPPGHISFAPAPTRLQRASRISALEIAVRAQAKKFLSHPLVMKQLEAIWTGNIVFHSALDQAHRIKQDKRWPSPGGLTQLMSFRRSATVYDACDASLFKLSRLRVPRYKHITSTFSLAILLLLYVMVLINRSYEITMLEAIFWAWSFGFMMDEIAGFTEAGVSLYFMSLWNSFDMGIYLLFTTFYALRFIGIMIPGEGNYMTNWSYDVLAACAVFLFPRIFSVLDHYRYFSQLIIAFKIMAVDMVALLVLILISCSGFFVAFTSFARDSYSAREICYALFQILMGFTPAAWESWENYNLLGKALLSAFLIICHFLIVTILITVLTNSFAAVAANSQEEHQFLVAVNTLSLVKSDSLFSYTAPLNLLGWILHPLRHVMPFRQYVRLNRTVIKITHFPILLLIFLYERTILGNSIFEQSDVFSKKHARRAVQESLDPLDQGVFSPVARRIRAGSVASHHQDRALDEVFRRPYQGEPSIRSGRKMDVPGGVVASWMKGVVSPTGSPPTEFEDGFNIRRRAIARGRPGFAKLAKRDSYGTIEDLQRNAVLGKPTRSVISDPEEFANTGEMEGLGGFKESRIKPEPVDVIGTEDDGDDEANSRDEEDEEEITNDTEDHDNGEPSSEQETGGENTPTKSTSTKSIPGLPKEPSFTKLTQQALRKQFASRHHLRTDSSQTIKNAFNPPIVQSSEDEFERISPIRLSRQNSERTAVWAVDNASGKKHSPRSSRPQTATRARAMTTPRKFLQSLPNLEGLHLMVPNDEHVRSPSPILDLAQHPEEPQLPSSFATQMAMATGTRGGVADLMLGRMVLSRIGNLEESMKDVKLILHEVKKLNNKGKEKPRSLPDEEFEEKSRGRRGRSDGTVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXW2</accession>
    <name>A0A2T6ZXW2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1172371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXW2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXW2"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="903"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1046" mass="118581" checksum="1BFE16F05D4B5304" modified="2018-07-18" version="1">MDVSALRECTLSALDANADIRRQAEMQLKQAESTPGFIGALLDIVASDPELQVRLSAVLYLKNKVVRSWEFNEDFPKNPQIPEREKAGFRDRLVPTLASSAPQVRQQLMPLIGKVLHYDFPEKWPGYMDITLQLLGSNDIGSIFAGVQCLLSLCRVYRFKQANDKREELDRVTQATFPTLLALGNRLVEETSTDAGDMLKMIIKTYKHVVYFELAAHLREESSIVAWATLFLKVVGKQAPPESMADDLEDREAHPWWKAKKWAYSNLNRLFVRYGNPTSLAAANSENYEKFSKHFIHHFAPEILKVYLQQVELWVSKQAWLSKICLSSTIAFLDECIKPSATWKHLNPHIGNLISHVLFPLLCQSDEDLELFESDPAEYLTRKINFYEEISAPDVASTNFLITLSKSRRKQTFTVINFINDVVNRYEAAPDNEKNYREKEGALRMIGTLSAIILGKGSPIADQVEYFFVRHVFPEFRSPHGFLRARACDVLEKFSDLDFKDENNVVLVYQNILQCLDDSELPVRVEAALALQPLIRHDFIRKSMQQNIADIMQQLLKLANEVDVDALSNVMEEFVEVFASELTPFAVQLTEQLRDTYLRIVQDVIDKGANSLDDDADNYLDDKSITALGVLQTIGTLILTLESSPSVLLLLEQILVPVITITLEHKLFDLYNEVFEIIDSCTFAAKAISNTMWAVFELIHKSFKDRGEIYIEEMLPALDNYVSYGADTLKENPALLDAVFDIIRTIFTNDRLGAMDRICGCKLAEAVLLNLRGHADQYLPRFVEIAMTCLNAPGDIKSYRIHLMEMVINCIYYNPSVTLQILEQHGWTNKFFSLWFSNIENFNRVHDKKLSIVAIVALIQLPAEQVPQSIQPGWPKLMQGIVQLFQTLPVAMKNREEIQKEGLTLDDTYDTESDTEWEGEATWSTDADEGDEADIPDESSAYMDFLNSEAQARGGLNLGSTWADDEDDLEEETLLETPLDHVEPYMLFRSALMDLQNTQPHIYEGLTKALSEDDRNIIKGVIMEAEAKSRASEATAAALGVKNGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZR4</accession>
    <name>A0A2T6ZZR4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZR4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZR4"/>
    <dbReference type="OrthoDB" id="5399446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="734" mass="83359" checksum="AC2EAB14E36D11ED" modified="2018-07-18" version="1">MPSSLKRKSNPEAPHAPSKRLRTDGLFTPRVKTPTGASRSIPRASRYQPSSASPAKRTLDEEHVEQDLSSKVRILNSRECLHLLPSRKPLSVPAPELQRKIKPRSPLKNAIIARLSRRRAILLQKQKLEHLMERMDSDNVYYFSEGLSNGIKLFTSRSPASFSSFSVDIMDVEEPTNCTTTITSDSPSQSASDPESPAEEMIRTKVHEEGGSKKSGDVDEELDQEPEPKPEERTEEEKDTMKDTGAGPEEEKDLMKDDEAEEKGEDKKEASETLSIKDKLVNDRIKERLGEDGMVCLSVKTKKAEEEEEEEEKSTVPKKSPTKKKVKVVLPPTLEEDEDEEGKEPESPKKRNSRPSSPQKKREEADDSSDSEREDREEKPRRRSLKSSIRKSEGEEKEEKEEEKEPEDPEKMVSQPRPRHEHEDSNPSDTEKDNDKRKEEEEEEAATHVDKMEEDADADEESTGSSGEDTDMSTDDEAPTETTESTEEEDVAMCEEGNEVRGSGNTSDEKRNKERQEKEDEADNYDNEESSTPIKTDSKTSDEEAKKPKRVKSLVLSSQAEEVEVVSAPKTPSSAATLRYNFSIAKTPKSPRSPRLFKHDLVPSSPLGFSGFSNKKKKTLLKPEIERDASLWMLGKSSSLHPKRRRQRPFIPANVSRHAYRDSDSDDGEDMYTHHHHGFQSSRRENDETEDDDLYLRVDWPWDGRGRYSSWMMEHGGPLLEFCVRGLEGFNMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A058</accession>
    <name>A0A2T7A058_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dUTP diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_972686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000051">
        <property type="protein sequence ID" value="PUU81090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A058"/>
    <dbReference type="STRING" id="42251.A0A2T7A058"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7025" checksum="E5EF9FA20AA82686" modified="2018-07-18" version="1" fragment="single">YRVQVKVLLFNHSDVDFAVIEGNCVAQLILKRIVTPEVVDVDQLDEAATVEDMAGSEALALESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A079</accession>
    <name>A0A2T7A079_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1077757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A079"/>
    <dbReference type="STRING" id="42251.A0A2T7A079"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="364"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="505" mass="56355" checksum="7E5E337DA9799C4F" modified="2018-07-18" version="1">MLAERLSRSRSRSLGRDLEPPNSHVVGAEKVFVSPSGSATSSSLSSLSSLPSSSRSSPILINSDSPQKVDPPKDNGSNRSSPIELSPTSDDDRLNKPSRATAKAPPVPTWKTGEEKRGGKRPVSFKKASYGVNGKGGKSTVPYAKELMESHPPFKLKPRLSQLKSSRRALSCAEKHQEKPQGEIEAVTTSTVATRVSKYKNKAPKISGPLHLAAHERDADLSSEENEEVAESSFINPREKFGSGVIREVGLKRLLDDDDGDDDLPSKSSRSTPKRGRFMQSPSPGIEKTECQMCEEPLPANFLDTWKNGEFRKGHIPMLEWMDICTEHKAVSLREEWMEKGYPKIDWQGMKKRIETHYKPIEAIVHGEIESPFMAIFQQQEKDVRGNPILLLQKDHRLQYPGYYGPRGANIMLHWLLRRFGSEINAHNNATSNLAHSSAAAFVQAVLVPEMAVRLIMEDMKVAEKRAREVLEESRSIGETLNLKDYQEDIYGTGDNWVDVNNFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A081</accession>
    <name>A0A2T7A081_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1077883</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A081"/>
    <dbReference type="STRING" id="42251.A0A2T7A081"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="140"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="359"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="568" mass="62831" checksum="7D58EFF46BE9A0DA" modified="2018-07-18" version="1" fragment="single">MLYSVQHNAKFVGAGVTLDLERICPGICACLWGELDVVGVKLRVQTEAVGAFEDIGKVPVDVDQQADSAARKCVMYFGPNHNPALAIAFRNRVVPDAQGAIRLVEGLGEYEATYGYELRGYKAGRTEGDLQRPPTKIAFFSATPQGSGVALMRHALVRFCTELGVNLEWYIPKPNPKAFRITKTNHNILQGVADPEARFDEDKQNLLNEWIGTNAKRYWLKSGGPLAPGGADVIIIDDPQMPALIPIIKKVRPEAKIIYRSHIEVRNDLVDRPGSPQEQVWRWMWNYIKQADVFISHPVDKFVPHDVPLAMVGLMPACTDWLDGLNKPLPEWDLIFYHHDLRNSCNELGMNQLLCPAREYITQIAGFDPSKGIPDVVESYRKLCARVVKDTPEKLPPQLLLCGHGAIDDPDASIVFAETMELLAQPRYSAIAKDVVVMRIGPSDRVLNALMTTAKLVVQLSLREGFEVKVSEALHHGKPVVATRAGGIPLQIQHGKSGFLIDVGDTDAVANHLFDLYTDDDLYAKMSDYAKASVSDEVGTVGNAACWLYLAAKLARGQVLKPNARWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0A2</accession>
    <name>A0A2T7A0A2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0A2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6328" checksum="A900C220C5B873F4" modified="2018-07-18" version="1">MVEVAAMTIKKILMVAACLGRICNIYFYFYFLFLEGRGDFVCLRGVLLGRSLHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0L8</accession>
    <name>A0A2T7A0L8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1077441</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0L8"/>
    <dbReference type="STRING" id="42251.A0A2T7A0L8"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU81270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="247" mass="26172" checksum="85BBB07CF1ADF766" modified="2018-07-18" version="1">MARKFFVGGNFKSNGTTTQIKSIIEGLNQASLNPNVEVIISPPAIYLPLAKEIASNGVQVAAQNVYDKGNGAYTGEISAAQLKDVGVNWVIIGHSERRALLGESDKFVASKTKAALAGGLSVILCIGESLEEREAGTTIDVVTRQLKAVADEVSDWSNIVIAYEPVWAIGTGKVATTEQAQEVHAAIRKWLRETVSDKAAEETRILYGGSVTDKNSKELATQPDVDGFLVGGASLKPAFVDIINSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A174</accession>
    <name>A0A2T7A174_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1077063</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A174"/>
    <dbReference type="STRING" id="42251.A0A2T7A174"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="372"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="649" mass="71079" checksum="3B521EF2F247B99C" modified="2018-07-18" version="1">MDDPSTSETVAEKFGELSPEVLSLLEGMLRIYGIPAEELFFKWESYCIKMGPDDTKLNLDTVLAFKKDVQELFEKDMRSRPRQHGANTSRPVARTPRVKNTGDHVAFLDGLVPTTPRGAKGSVKRKFERAPFETPSSKAGRFLDANSPGTAIGSSPVGTPHKIGGERIPSTPFAQRKNAGSTVEVLNEHIPKPSLPLPESSADAELALWDSRAKLSLAVELKKFSYRPMYQKLSEASEVMDDRVDEFMDMIQEHHELADEQFGNPSTASPSEIIAVGRISCDTLDGKLSPSSVLLEASRKMGAGSRVRLKLDAVPSYSFFPGQIVAVKGVNASGEYLVVSEILDAPGLPCPASSPSALLETADRLSAGGLNIVVASGPYTTDDNLHFEALSEICNKAAESCPDVLILTGPFIDADHPLIRTGDFDFDTWHHDRSPMEDLFCQRITPKIRRVQRSLVILVPSVRDIVSKHVSFPQEQFKRKQLDLPMNVKCLPNPATFSINEIAFSVSTNDILFHMASHEINRNPQDTNPIARLSKALLGQRNLYPLFPGPSKEQLPRGTTGPNLDVPNLRLADFVGIAPDVLVLPSMLASSAKVVDSVLVLNPGFLSKRMGPGSYAEMHVLPPQVKGGEGEGELSHRVWERARVEILRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1U1</accession>
    <name>A0A2T7A1U1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1106194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1U1"/>
    <dbReference type="STRING" id="42251.A0A2T7A1U1"/>
    <dbReference type="OrthoDB" id="5383967at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015580893" evidence="1">
        <location>
            <begin position="16"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="238" mass="26669" checksum="782916AE59B4E405" modified="2018-07-18" version="1" fragment="single">MVNLFLLLVLSSSLAVPRKAGEIRSPIGISVATGAALEVTTTTVKPSSTTTKILTISTKGVYYFYERIYYYCERVYYYCGGAYYHHGMGYYRGIVSTEANNHAEGVWAPVAIDCSDSSWEPTVDGWMAEDVDQKLKGWWESIPDRANKNFVSEFGGAFGDFEHNLACGVDTEDQCVNPSCKVFLDANAPKWTYFVRVAISNLNRNMRLIHDGIGDGQMDFEALREDVAQSFLPWKDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A212</accession>
    <name>A0A2T7A212_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1121691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A212"/>
    <dbReference type="STRING" id="42251.A0A2T7A212"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="459" mass="50621" checksum="4774FDFA44FBBB66" modified="2018-07-18" version="1">MKCPFSFARSCFKSLQISLPLLFLRRFTKLCFDVENTFTEQPDGRVLTGAPELAPIVKLKAHGREPSAFQTDTEEVIWGQNGFPDRGDASYYFYQILPHYYLSTIDIKLLRAAFGAYSDLISTILPRVGKVATGYSVDDDFRKGANSVVHIPYSYEISFMDCECADIVSAEVLETFRIEIDQWKKGKQEKDARKKVAWIQCSQRGSPSVLSPDEDGRLFVVPSRPPGKLPDDSGWGTSGPTVAYPPTFPYIRLILLVAGGGRLPSFTSIRLCPAVPHRSRSLSAVTSGHLPSFTVPAVTGCHSPSFTVIHRHSPSLPLTVVTCRHSDSLPSCTVDYSSSNTTTTGTGHLSSSRPVQGSWQSVRRALSGPWTVGNTAWIRGNNEEYNLPNPIPAVEELQAILTNLPTQDAHINSKRCTLSTKMLTPSKTSVQKVSSGMKRWISSHSASEQPSRLWPRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A355</accession>
    <name>A0A2T7A355_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1062175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A355"/>
    <dbReference type="OrthoDB" id="5426488at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015588568" evidence="2">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="246" mass="25225" checksum="F752E708BC0BAF1A" modified="2018-07-18" version="1">MVSFNVLAAAFAAFAAVSEAAYHGHVAKRHLHMRASYGNITDIPILLGTGGPAPVPVPTSKAVTDIPEPDFTTTLTSTITKSLTVTYTLGNGKEVVTTITKLEETTKTIAHVKATLTVSPVIESTPGVPSVSASSTVAPVPVVSNNSGSSRTSTTTQYVTAPASGTLTVAAASSAPACPSVETVYLPTYITVYNTVTAAPPVPSINNSEKAPGQSTTSQTTTRTSTTTVSVFKTVTLTKPPYSTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3A8</accession>
    <name>A0A2T7A3A8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad17 cell cycle checkpoint protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1075591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3A8"/>
    <dbReference type="STRING" id="42251.A0A2T7A3A8"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="524"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="867" mass="93390" checksum="39A2C3EAD234A099" modified="2018-07-18" version="1">MPAPAPKKRRVVVEISDDDHFEEELSIAPSSSASQRRTRASTRRAAAGSTPPAANDAAVRKTSCPAPLKPKASNNTPAKPRGTTRKSTASLQKKAPAMNKPISSFFTATQRPPSSSSQNARTSVPPASQNEVFDDLIEDAFSDGGFEGSSAVQVGTQTRTSSLSGAGRFKVGGGGAIGKGRTTESKGSSIVKVTSKVQIVDPRPWPERFAPQSSNSLAVNPKKVSEVRSWLKHVLDGFSKQRLLVLKGSAGSGKTAVLEVLSKEIGFEVLEWKNPGSVIPTEGPGEGGAFSSGLTGVFEEFVGRAGRFGCLNMVSTTPSPRNNAEGKRSTNGKPLPKTDKSKKKVILIEDFPNALFTSSPAPLASFRHTIKSFLAVPAPPRFSPPVPPLVLIISESADISGSSAFTAHRLLSPEILHHPLATSITFNKIAPTFMVKALSAIIIQESHESGRRFGPSNPMLQALSSSGDIRSAIMGLEFLAVNGELGAFSEKVDSNEQAKRKKKSGDSDLNEIERETLNAVTQRESSLGFFHAVGRVVYNKRYGDDAGDPYMPPPPKPPLSHFPYRARASRVDLDGLMDEAGTDPQTFISGLHENYLGSCNLLGGLSRSDYSMEDVLSCVIDCIENLSDSDLLASPKPYHRILGRLGGYEGGDAAMGSAGIRQDEISFQTAVRGALIGLPTPVKRESRDTKMYYPTALRLWRDQEEIEGLIDLFGKRFHTVGDHGDFGGDGAVGTGRTGLTLERMPYSKIILKARQQRKASNRPFNRMAFEMSGKLAGIGALKELEKVTGLRGVIPPRSEDVPSNGDDDKATQSAPPDELEAAEERGKLPSRRYNTARNYKKSKPEELDTAAHVERLVLSDDDIEDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3B1</accession>
    <name>A0A2T7A3B1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_477239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3B1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="9091" checksum="5BC0EAA73E55D7D3" modified="2018-07-18" version="1">MVYLYSIREKRRFLVRVLRLGTCCTWWLAGCPCDMSTLLLYRPRASYSCRCNQSLRLENLADEREHSTEQDTLGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4L1</accession>
    <name>A0A2T7A4L1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1061580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4L1"/>
    <dbReference type="STRING" id="42251.A0A2T7A4L1"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="236"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="454" mass="49031" checksum="DF9004C358F23452" modified="2018-07-18" version="1">MRLILDYLFHYSEELYCCDEFVQGEVGYGFQRVRYCSLACFVTDDADESATWENTYFTDEEVAPLVGPLLAQCVLVRLQAGSVDAGFLAAFCPIQDVPYFTVIKHGALVANIKAGDSREEFVRLLKGAFTEPQDAPPAAATEVQSPASPALAPAPTTPPRVPVASSGVPGRTENSSFLQQQKKRQQEASEERQRVLQLLENDKKEREARRRKKVVEDKAPSASTTEPSERGTPKSHSSSETAISFRMLDGLSLKAKFPSSAILATDVRKFVDQHRTDSDHPYNFLQILAPLPNKQITISEENSTLSELGLSPTCTLVLVPTSSSPASAYSGGGGSTEAGGIFSRIYGFLYSIVTTLLGVGYYPLVPAPMNAELAQSQSLPTASLLSSGDASASSSSGQASSREEVAGTRIRTLYDGRGNDGDADRKYYNGNQVCAVFISSMRGDSRANDWTAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Q9</accession>
    <name>A0A2T7A4Q9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Q9"/>
    <dbReference type="STRING" id="42251.A0A2T7A4Q9"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="453" mass="51208" checksum="64E4F79BDEF9AECA" modified="2018-07-18" version="1">MYWYEVLMYEMSRKKLLSQTRLSLNPPLDQPQSSNPPADHPAAMRIFELGTLNSQEELSILDTTPPASTKPSFLSLPSEVICLILDFIPPRAQKRLARVCLISRQWYIAAIPYLYRYPIITPANYTKFVTTISPSGIHVKPSRFAGLVKRIDLSCIVHESRPSLLARLLRRAQGSLEEFVAPQTAFGYIALVAIGHCQQLRLLDLSLVSQSIELETLFRHIQDLPHLVTLYFPPSSVSDGSKLAFYWPPRLKYISLAGGIENSFLTNTCVPSTLHELQIAHCPFVKDSSIKHLLNKASHQLTVLSINYYIPCLGFNAFDKVLIICPHLEKLTIAVDYVSAHLFEEENSPAGHPLRWLNLDSSGNPGVEKKITPDDIFIAVAEERLSELRVVRARKKLGWEENSKRMVVDLNELLETRAEEKGETGAGVWIFENDYSSQCEAFKGWWNGFGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5U2</accession>
    <name>A0A2T7A5U2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1119740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5U2"/>
    <dbReference type="STRING" id="42251.A0A2T7A5U2"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="4">
        <location>
            <begin position="37"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="315" mass="34707" checksum="AB5C797FAA2C51FD" modified="2018-07-18" version="1">MNVKSLAEICREYERTIISSGGGDESVSIEKLVTIREVQTPILSDTFGGAVAKPFLTEATRAYRGKQLALRIAPELWSKRLVIGGLGRVFEISAQFRNEGIDSTHNPEFTTCEFYQAYAGLEDIISMTEQLLSSLEVSELKSGKLKDLPPRDRNGLHGPLPKTRELLSLFETLYPHAPNANYPRLLDKLSSRYLEPQCIEPTFLRVSSELFVNGKGLVNAYEENSPTEQRRKFVMQAGWKDDDVTGGGEDGEEVDGHIAMTRVGLAADGWMGSVLIDWLWSSPGAERIAEVLAFGGLKGVVNLGDGVRSVNKEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5X9</accession>
    <name>A0A2T7A5X9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1112559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5X9"/>
    <dbReference type="STRING" id="42251.A0A2T7A5X9"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="224"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="428" mass="48936" checksum="344B5D84AAD74893" modified="2018-07-18" version="1">MTTLYKTFRRALTTKDGALLGSIFSPENPDRGTFAFSTNHERIRGDAEYEISGLTPLRDENTRGAWVDTLVSYWKIAYILERDDGADVSWAKAYEGQKDLLLAMVRGYTKGNWPHWTLPVMYQICLSLRTVAILSDDQARRLGKTSEHLEDAARYINKAFTLCISDRAPIEESRKWGTYYIVNLMFKTYFKLNSVGLAKNILRVLPASLADMPPLEAFPKSHVVTFKYYCGVVSFLEEDYGSAETHLTYALDNCKTDSIRNKELILTYLIPTTMLTKHKLPTPELLSRFPRLAALFNPVCKTIKSGNLQAFDAALRHGEEEFVKRRIYLTLERTKDIAMRNLFRKVVLYQNEENRTKIPVRQFQIAMGLEADGDTVMRSTPERVEVEVEEVECLLANMIYKGLMKGYISRERQTVVLSGKEPFPGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A622</accession>
    <name>A0A2T7A622_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-apo-4'-carotenal oxygenase</fullName>
            <ecNumber evidence="5">1.2.1.82</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Beta-apo-4'-carotenal dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_965314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.82" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A622"/>
    <dbReference type="STRING" id="42251.A0A2T7A622"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="563" mass="62451" checksum="CA3F5969DC7A8DE7" modified="2018-07-18" version="1">MASHLLIPFSSTPVESIAPTVSRLQSTFTSLKTHPLAYREEQLRKLYWGIKDNEQRLIQALKADLGKPYFEAKVVEIDWTCADLLYVLKNLRKWAADDKVDLPLLHRLVLSPRIRKEPMGTVLVIGAFNYPAPLALAPLIGAIAAGNTAVIKPSEQAPHSAAVITRIIESALDPEAYAVVNGSIPESTELLNQKFDKICYTGNGAVGRIVATAAIKHLTPVLLELGGLNPCFITKSADAKLAAKRIAWGKFHNLGQVCLAPDYVIIHPSLEAEFVGAFVQTLKEFFPEGASKSPDLGRIVNTRCYHRITELLNNTKGTILYGGGQDESRLFIEPTLVKIASPEDSLLSEEIFGPLLPMLAVEDLDSMISVARKVGDCPLALYIFSGEKEEEEKILKNIRSGGATVNDVFFHAVLPSVPFGGVGESGTGSYRGKASFDAFTHRRPVVNQPLWMESQLRMRYPPFTPKKLDLMRKASGTTEPNFGRDGKLLRRSLVSWVLLLGAHSRKRAAFRYLLLMAGRKHTPLWQFVVLVLGECVKMRRHMVTMSRCPLQVLMRMKMQELRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6H5</accession>
    <name>A0A2T7A6H5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B12 subunit family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_965099</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6H5"/>
    <dbReference type="STRING" id="42251.A0A2T7A6H5"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8494" checksum="469FC3C86E81A2BF" modified="2018-07-18" version="1">MPPRPPFNPQILLKKPTRPDPWARAETWRYTGPFTRWNRFKGAFPGLGIATVAFAAYCTWEAVFMKKDEHLGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6N7</accession>
    <name>A0A2T7A6N7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_965148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6N7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="13612" checksum="37AC2DCCCBD9BD41" modified="2018-07-18" version="1">MRGTMQLTSNAWGDLEEKCRFVGPHNSVSQSDCLIDNVRSEAGQSQMIGSFFVVFFFFLRIFFPSRGVKEGQSLIMSQIIFPCGGKQDSCPHGDYRCECCAEHAISIANPRHCEHSLFIGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7D8</accession>
    <name>A0A2T7A7D8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_823135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7D8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="19954" checksum="B3EBE1CED0998EEF" modified="2018-07-18" version="1" fragment="single">ICKKVNKKPSDKGTQKKKSDIACSLQITIIRRPSSTTTSKNPHPRYRRRRRRCHSNRGHNRGLHLTHTISADTTTTGRLVLTNGNNIDTLHPVHDRLSQPPRALPPLLYQASAPGLLVVVRAPSAGEGDFHPPAKVLTGWSARVVRCEVVVTADEAGRCEYRHFFILSCVFMYLCVLGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7H4</accession>
    <name>A0A2T7A7H4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1118788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7H4"/>
    <dbReference type="STRING" id="42251.A0A2T7A7H4"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015657339" evidence="7">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="154"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="360"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="458" mass="51215" checksum="4C401F0EAED82D81" modified="2018-07-18" version="1">MLSSLPLTLLLLPATAVLAATVTYDFNITWTTANPDGLFPRRTIGINGKWPIPTIEVNKGDRLIVNMYNGLGDQNTSLHFHGIFQNGTSYMDGPVEVTQCPVAPGQSFKYDFVVNQPGTYWYHSHVKGQYPDGLRGALIVHDDNSPQKSLYDFEVVLTFSDWYHEQMPKLISRFLSVANPTGAEPVPQCALINEAQDTKVKVEPGKTYLFRMINIGAFAAQYVWFEGHTMRVVEVDGVYTKPMEAGMLYLTAAQRVSVLITMRNSTGENFPFVGSMDQDLFDQVPKGLDPNVTGHLVYSDSNKNPPAKEIPEFDPFDDFLLEPEDGEVLLENPDYSFNLDVVMDNLNDGANYAFFNEITYVAPKVPTLYTALSAGEYATDPVIYGRDTHPFILKHNQVIEIIINNLDPGKHPFHLHGHNFQLVHRSPDDSGPYNYTSPQTPPKFQCVGMLSSCDQTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7P5</accession>
    <name>A0A2T7A7P5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1071591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7P5"/>
    <dbReference type="STRING" id="42251.A0A2T7A7P5"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="698"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="733"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="942" mass="103359" checksum="E9F7E39321E61E3F" modified="2018-07-18" version="1">MSKKDMSIHEKRLASFTRKRRASSAVGNKNTGGGKWPHERPSPQKLADAGFYFNPSDAHLDNVTCYLCDKDLDGWEPDDDPVSEHFKHCPDCGWAQVAYALAFRDDHKALSDPRGTMMAEARIMTFGKKWWPHEDKRGWLPKIETMAGAGWHYAPVKDSKDNASCAYCELTLDGWEMNDDPLEEHRRRSQDCLFFTWKPAPKRATKRASRASIQSLASSIGDGEDEPVRIIARGRKPKKAPLARELSVGPEPVLIDEPVKAPRGRKRASSIIQNPEPVIIWDGAKDTDEDDAQPPPAKRRTTRASLAKQSSVNLNVDAKMADSDNESVAAGPARGRPKKGVRSASKTRRSVVKKNSKTFVPDDDEIDRALALDLERPLTDEEDVATFKKPFVRTTKRLTRSRTSIAVEESMRNAPEGVLIPTAKRGDRVSRTPLGTATPGSIRRSPTKALFKDNNQDFSMPIVIPKHLAQADAEEGPRSPQGIGRYEDKAENAHVEVAPAEELEPNRSVAKKVARGKRAVPPQEAEAPKPRRGRVVAKAQKPSSRNTSVDNQPPLPAQVESEKPVVEELPPPPTRIEEPSEAPLRTKRVRKIKGRASVLSTTSIDSIATDNTDAQMTSSIKSILSDTAAAHNMTSSMRSIVSGTTGTHNMTSSMRSMASESEQIATSIDESIIIHDSVIASEAEAVLSDAGSVIKYKINPRDRQPKEEIAPPPKIKRGKKATVPPKMRPARSSLLSTTTDKTASSVGNSGDESDASRASASGAGKKSKKGSKKLGKKTAQSRNIEDILKKGSESFFASSQSEELTSSIHEGSKKARPVKKLMKAIEIEPRNSAKPIDPDQTEEDEPRSIPKGSRPGATGRSLATVRPWTAVDLDTVFHGSDVEIDESASLTEKEKEMTVADWVKWNAARGEERLCREAEKLIEIFEREGRRAIDAVEGIETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7V2</accession>
    <name>A0A2T7A7V2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_962341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7V2"/>
    <dbReference type="OrthoDB" id="4768051at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="610" mass="68137" checksum="6C54751821771AC7" modified="2018-07-18" version="1">MSYRQTRSKPSDALQTSLDSGTYSTRESLVEGSNERQLKPFSSSDQSRRDLIALARGFLQTLFAFVLLVICLWQFSKLQFLNKWEQRAFNMLSILLSGIASLGLGSLLGYLGSMLRWPLLARTKYQMQDVDSILGMARLIGSLRLIKRHVRERRISPTTFIVTAYLITNVLGRLSVAIFGLAYNMMDNTGIRHPILATNWASASWTNHADTATKEVYGPDPFDSEAAEGKAATLLNLSGDDNPYLVSDFRVSNSTLKEPVGPNDVEYSYQLKDFKEGYAILSNRIVHSTANCSLIEIGEGQYWRWNNWERTGPFGWGKDTHNVVSSVLQGSNESNTEFPQWISIENDYENDIFSQIYIACGYYAWECWPTLTETTANESHQIQPHERFFPSTSLYSLSALGKDQYGNSTQNYTLYTNDFSSSSFGPAALDGACYDYFFSMPLNETYWNDSRLWVSSLVARLPIVAITYANTVLPQYTRDTHSNQTAGTAYLRTSLEVNWHRVTLITVGIVVGQILAILVVLCYCNGVYTRDDSHLATAELLKTVINRFDGGKLMTGEELAVSLDGVLGAPVSYGTRGGQDGSPPEVDLASGLDANFPPLPPGQRFWRNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A850</accession>
    <name>A0A2T7A850_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1060672</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A850"/>
    <dbReference type="STRING" id="42251.A0A2T7A850"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="233"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="422"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="521" mass="56884" checksum="584D28C56CE08B85" modified="2018-07-18" version="1">MPSTRIVLKLNSNQSISAPYLLPQTVNPRAQVLSCAKSKFRIKATRIFLPGGQELLTSQAVQDVLNLSHEHRTVGPTFLISAGEPYVGALAPPPSAHAETRTCEVHVIAEDSYVDPQAITQLETAAKLPGMVRAVGLPDLHPGGKFPIGAAFVSDRYIYPSLVGSDIGCGMTLFMTGLTRKKLEDQNGIKRVAESLRGLETAWRSPQERAAWLGDCAAGDEWDKSVGTVGGGNHFAELQILEQMEEGHGLCSGIVVLLVHSGSRRFGKHILETFTKDDKSISLAYGDPKTSEYLKLHNQACNWASKSRDLIALRIFECIEGSRWILPETIDLDTAAHLNTRLQGRRVLDVLHNTVTPTPWPPHAEVQHQKSMFIHRKGAAPAPQGTPFLPLPGSRGTPTLLIKPLFSELNQNGFDNGLSLAHGAGRTLSRTEARGLSRKYNNDVKVLTEMKPMGMRNGGKGRVVTSGYVICDEKELVWEEAVEAYKDVEAVAHDLEKCGAAKIIGKCIPKVTYKVRNESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8F5</accession>
    <name>A0A2T7A8F5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1071335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU84018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8F5"/>
    <dbReference type="STRING" id="42251.A0A2T7A8F5"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015675185" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="19779" checksum="83ED1569511D1C0B" modified="2018-07-18" version="1">MKSAIFSSAIAIFATLATALPTETANNLVPRDHVKQVINSSAVVNIREDTPDTALGVSGRGTVSRTDGKHNFQALVKFDIPDGLTGSKCQLAFAYPSLFDGTSQIQVFSIGDANIENATFNKRPFRDQFKGTFHVGWGEATVVDGSGLTFDCPVKGAKAYEVVSVGDNNDVIWDAPWGGLRVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8L1</accession>
    <name>A0A2T7A8L1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_563473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8L1"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="23717" checksum="A11F21BC2DCEE65F" modified="2018-07-18" version="1">MQYKSDICLSRSSVAVVGGFCPRPYTPTHLHTGTHIRSLTLYCPFPTARDVLYKVQQEKNQIITHLKPEDMSSFLQANRRLANLLTADFAKILSARRYPNRDKRLRKQYKLKRRMAAGWVRKQKAACAGGRNCVKGRGRGRGACGSVLRGEEGGKPSMSSGSAALLLNKVPATVNSAHSPGSSRPVSRGVYSGVNKPLPKVRWRTGIRHFDQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8S7</accession>
    <name>A0A2T7A8S7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="3 9">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_961801</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="9">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="3 9"/>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8S7"/>
    <dbReference type="STRING" id="42251.A0A2T7A8S7"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU84123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="392" mass="43395" checksum="7DE5FB94B557FC7A" modified="2018-07-18" version="1">MSSAALTSPPDSPTDATSPASVPPPPDLSSVPLLSEDLQLTYLAEGAANIIYRLSAPPGAPPTDEYANKLLRLRKALPSAQPNLLAYSHLLHTFHPLFPSHLLVPTTLIKVPKSVILRENANLLQLEDAGKRPAKRRGLYLEEEMEDYGFVILDMSPHPIEDLPPTPPDTDDTTAPLATSVITGEFKGKGFLTRQILVEFKPKWVVQSPSAPANWKRCRTCALGLQKRGGKPNLCPLDLSSQEESRVRNTLQHILPSVPPKNLQLRPGESWEDAKKVIENHTADFLVSSELMPLLKRLQLEMDPLGPIKVAREGNQDYREKFVTAMTVRDLTMFLRIDLDGGVEARIGDLDLKTGEAGKWDYWSKVEQTLITDGYYTGTEEGALEKGLWCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9A1</accession>
    <name>A0A2T7A9A1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UAA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1070051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9A1"/>
    <dbReference type="STRING" id="42251.A0A2T7A9A1"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU84316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="377" mass="41658" checksum="20603CC424501DF9" modified="2018-07-18" version="1">MARGAQRRKSALEDAAGISKIDARPHLEGRAPPTRSAISAIAQATIPVWVQTAAMIGLIFGGCCSNVFALEAIVKAEPQTGHLLTFAQFLFVAIEGLIYHFDTSSKTLLKPNQIPIHRWLIQILLYFSVSILNNYAFGYSISVPVHIILRSGGSMTTLVVGWLWGKRYSKVQVLSVLILTVGIVLSAWGDSKGVGQTEESMAKFITGLAILFVAQVISAFMGLYIEGTYTRYGNHYREGLFYSHFLSLFLFIPFIPSIQTQYHKLLKSPPLPLPTSRFLQTLQIQIPRQVFFLFLNAGTHYFCIRGVNILASRSSALTVTVVLNIRKLVSLLLSIWLFGNALNWGVVIGATVVFGGGFMYAAESQRLKGVQKRKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9N0</accession>
    <name>A0A2T7A9N0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9N0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015443926" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9646" checksum="03799B04B77A2D76" modified="2018-07-18" version="1">MLHWQHCIVCFYALSLLNHSFHCDECALVATHSHARLQWRDGKGEEERNAKRAKAQDRKRLANVLLSYQLFLISTHPRLQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9P4</accession>
    <name>A0A2T7A9P4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1060312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9P4"/>
    <dbReference type="OrthoDB" id="6594069at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="13939" checksum="BF80F5BAF5C91CD2" modified="2018-07-18" version="1">MSKQRGPTTSLAKRGQIVGLANLRSDRRLSLKEIANETNVPLSTCSDIIRFSTLRISEINIPDPCFEDNLRPRPTAIKGQNQALSVEEKARVIAIALQDALHCLIYSQTFYPLMVSTAATLQRSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA81</accession>
    <name>A0A2T6ZA81_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1137902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000563">
        <property type="protein sequence ID" value="PUU72356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA81"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="8"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="493" mass="50939" checksum="8803CA7396776ADC" modified="2018-07-18" version="1">MPAILAFYIAALVAGTILFGFNLAELNAPQRAIEKDLSLTAAQFGLASSILAIGGLFGSVIATPGMNALGRKKVLISTALMFGLGGFLKAGAQGAVIFITGRFVSGIAAGSAAVIVPIYINELAPPNSKGAFGALTQISINLGILSSQILGIFFENPQKWRFILLIGGIVGVVQTVALLFVPESPSSLVASGDIEQARRQLIKIRGTPDIEEELAGYQSQPAGQSGGTGNTEHVGEHDSLLEAGPAPAPEPVNESSPLLEAGPTESKVGLLEFITKPEYRLGFMVVVGVMLAQQLTEDISVHGAGISRAAPTQEHVISASSTGKVPSSLRDHAALQLLVLRTDMLSGINAVVFYGVSILHDLLPKSAKFLNAGISAMNLLVTLGASPLFDRVDHKSLLLVSMLSMAISSVVVAVGMFVGSGALSAIATLLFVVSFSVGLGPLPWMVAARRMGAGSVGAAQSVALTANWAGTFAVGFAVPVVAHAFGMHVKFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA87</accession>
    <name>A0A2T6ZA87_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000546">
        <property type="protein sequence ID" value="PUU72412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA87"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA87"/>
    <dbReference type="OrthoDB" id="5499495at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="938" mass="106543" checksum="800FE6B2D85AF851" modified="2018-07-18" version="1">MNSYFFFYYLYIISIFNNYVTKSKRKASKSAEHKKHVKKVADQKRYVQRKVDANSISTHSRSKQYQENQSHISNTEVDVPDVPSAGPISSTTSRISSFTSIRNPARWVSEDLEEGVSEKEFENQGREDTIIHNDLQSVRWPKVVGLEQILQDMEIVEEPTFLNIQETRAGSEETVEIPNQDNLIQLEKNDEEDQELERRRVSAWPKVLGLEQRMQDMDISLEDCFHNSTSTRYLDTEGIGMVQEDSENENNHVGNHNSRKGKNVLRISHISDLGHSKLPDIMIDEDIEFQSAEDSDLLEANSSNSSDLISNTISSSLQSPIILFPDSALGTSPSTSHAIPSQPTINSVISNKLDIIEISSDSDSVKSSPSLNLKDTTNYLIQQYSYNFACSSDTYSSRSTATTSLSWSIARMTQWLNYHLPNDFPKPEVLGYGGRISSHQWSSLLCGISSESQTPPTLELPIPDLSIATTTTYDIDSFIAKVKCLSVASLWQKNLGTNSYVANQHLQQWMDIGFIPSILQHCPPDIVQHLPLSFASASMNTFARGRELGIQNREVYSAKRQELHYFLSGRYLKPIWQDMIKFSESTGYNHFEGMFLLVDAKDLKLQLKSSTINLGQEISSQDQRATCFFRRCCLENRLGEIKQESPGLKASNYSWALTTATANQTLAYSKCSPQFENGLIYSQFYSPLKSLFDAGSIYPFQNSSLDYLSLSPEILKLWQSSGIAGERFQVDMEKLEKSYTHSRDRVLLSLKTAIQQRRSFGLRQEHRVSFQLFQALKERADEIQFSKLPDSCYMQNSEEILHFLYANFLRFGLGLEYTASKLKACSFEQSHDLSRILRMFLQLQKASFTNSLLESQGDLWRSQTAVGVKNRSGLGLKNQLAAYKFCWLSPAVIDWNKWTFGKSFSQSTAFDYIQIHPTALHKTNHLLTRSLRGNIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAG8</accession>
    <name>A0A2T6ZAG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_666532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000529">
        <property type="protein sequence ID" value="PUU72475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAG8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAG8"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="21975" checksum="5F775A6165B7DC6D" modified="2018-07-18" version="1">MAGPVQALASKGFGTRLDMKIAGMGLIDDIGRVDSATYRANGSQNEADCAWKPRSCRPLKTDWPTVIIECGVSQSRDRLEVDAHWWFENSGGQVKMVLVISFSETKREIHVQQWEMTTIRNLHVTEDQPGPTSTAPTITGEFDLVAGVSNKASLMLNFERFFLRPPAKGNGQREGDIVFSRQELERYATHVWNYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAI0</accession>
    <name>A0A2T6ZAI0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1097207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000531">
        <property type="protein sequence ID" value="PUU72456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAI0"/>
    <dbReference type="OrthoDB" id="5333917at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="421" mass="48245" checksum="1358B8FDE39D59D0" modified="2018-07-18" version="1">MLQGFKSMGHHSWRSSLGIRPADRGPRQFYVRTTAAFRALKSYPPYQHLVLYCSIPAHNLDPTINTPPSLVYQLRPSFLSIHPAPEPTTQNQFSLHPFTRTSRMFLDTIGVCNPPPTMPEGYELHSSDIVPELVEIVTKPDHPLERCWPAFISQASSDHDLMYRVPYFSKYQFIVTHNGSPVALSNAVPFYWPELEQHGPQPYGTKGWRTVSETLPDGGWDWAWRSAMSLYFSNNPTTTTGFPEAEIYTGHENLVGKQPNAVCALAVAIDPAYRRRGIADALLQNYKDLTRVCSYEAMVVPIRPTRKTEFLHVKMEDYVSWAKWASAGVDEPFDPWIRTHVRLGGQVIKVCHESMRIEADVDTWERWTGVRFTSEEALCRKDEDGRTYWEMSVASALSYVRYFPDLNRGVYTEPNVWIRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAI8</accession>
    <name>A0A2T6ZAI8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endoribonuclease L-PSP/chorismate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129688</name>
        <name evidence="1" type="ORF">B9Z19DRAFT_1168555</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000517">
        <property type="protein sequence ID" value="PUU72510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAI8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAI8"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="137" mass="15335" checksum="0E4605335E71BDA1" modified="2018-07-18" version="1">MSHLRYYAYDGVGKRNLEKYYYSQAVRIDNRIECAGQGGWDPKTGELAKTIEEQIEKTFQNVQLNLKDAGGAGWSQVYRIRSYHTDLSPQALGLTIAALRKWCPDHAPVWTCVGVTALGEEGMLVEMEVEAQIPRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAM9</accession>
    <name>A0A2T6ZAM9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000520">
        <property type="protein sequence ID" value="PUU72496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAM9"/>
    <dbReference type="OrthoDB" id="5407383at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="33143" checksum="44AA954C74EE10D8" modified="2018-07-18" version="1">MGSPVAAGGVPAVGLAKAATFDISHTRDPISGCTRRNPSMPTGREDCTFEYQLTAQDMEADLDMTVYEEWEEDEEDQDVDFINLCESDEEDGNGSEDSDRFYGEEMIYEEGEEEEEETDDDGDNANNNDYHDDRERERSSDSPCRSVNGDVDMIGVGEISGLSLETASRDLDRSNLHYPPSGFTVMSQKNYFRASTQEIGERLLGRAITPKDFFISLEDPHDSIEYIITKRKQLLAGNAHLSIDLKAATREDAEEQGIDLKEMDRIDHEMDRQALLNQSWQQFPRTIKKEPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAP5</accession>
    <name>A0A2T6ZAP5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1104331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000506">
        <property type="protein sequence ID" value="PUU72555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAP5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAP5"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="283" mass="30498" checksum="8E00878B831FC21D" modified="2018-07-18" version="1">MITTTAIIALELKPTVLVSVPAVWENVKKGIMDQICIPGTAVLDAVVFKKIKATTGGRLKISMSGGGPVAKETQHFISMALCPMTIGYGLTETSAMGALMNPAEWNINSPGTALTSVEIKLVDFPDAGYFTTNEPEQGEILFRGDVVATHHGCFKTGDTSEWNKNGHLRIINRKKNLVKTSNGEYIAPKKLESNKTKPVALIIPFEGPLRKLAAEAGVESGPEELLHDDKAAVPRELIAAGRQSCLAGIELVEGVVLTEEEWTPQNNLVTSPQKLNCRGILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBA6</accession>
    <name>A0A2T6ZBA6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1096602</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000467">
        <property type="protein sequence ID" value="PUU72771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBA6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBA6"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="97"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1031"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1099"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="492"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1040"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU72771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1153" mass="127400" checksum="A637217541E58CD8" modified="2018-07-18" version="1">MSGPSRLQNGGVRKTNASSTMRAPATARPSSRNGTAHPQSYMTAARMGAGALPSSPAGSVASVSSRARGNTSPTKRRIKKDFPVEEPPPQQEDNEANINVVVRCRGRSEREIRENSGVVVSTPGGLRGKEISLSMGPLALSNKTYTFDRVFGPEANQNMIYDNVVAPILEEMLSGYNCTIFAYGQTGTGKTYTMSGDMADNFGTYSDSAGIIPRALYQLFHKLGIDEADNSVKCSFIELYNEELKDLLASDENNKVKIFEDSTRKGIVIQGMEESFIKNAEDGVKLLQEGSHKRQVAATKCNDLSSRSHTVFTITVHVKEIGEDGEDLLRTGKLNLVDLAGSENIGRSGAENKRAREAGMINQSLLTLGRVINALVDKSPHIPYRESKLTRLLQDSLGGRTKTCIIATVSPAKSNLEETISTLDYAARAKNIRNKPQINQMLTKKALIREYVTEIEKLKGDLMATRQKNGVFLTTESYSEMTEESESRRILNEEQQRKIDVMETQIKNTREQFEQNMRLFLDLKKELEGTKGVLEETKGELRKTETDLSSTRKDLADETVLREAHEKTEEELKSVGQKLITRLDETVHDVSGLHAKIRRMTDLEVVNHSNWMKSSGQVSTITELVEKEIGTFTEQQEKITDRVSERMSTFVATETKKLESAYEYIEARLGGFNDGEAGLSAETMKAKDEMNHVLEEIKILRENVKQKVGEGLKGLNEAAQRISAEVVEDLGKFGVQLHNSYSQLGREFKAIFDDAEKRIIAQKAEAEKLRLQLGSAAAAAVIATDTAQSSLDLILREERERATTDRQNLISQIAALVNATAEDQDKRLTKRVQLVQGEILMVWGEEKFINELVISQDSLKKILVQDWQDAEKHNASIQATTQAINAQTVRLVDAQMQDVGVQMQALDEFVTRARSQNEAHFEAFTQNLSGLSETVRESYSRMEGELNSFGEDLDSLDNDMSEQTSLSKELLEPFTSTTRQPLSELRGNIESAPLQEYVPTGETPKRRTYEYPTTLPHTQPHEELLLKPVTRRKSSTRTPLGEKEVHSPNKNVHEEPTDPKSGVFGKLATTGHPAYAHKIFFGTDIAAYTGIPARGGGGVSCADGGEGGQDEDDEPPAKRTRGQKLAVARGGYSAGSATGPAAPITAGNRKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBQ0</accession>
    <name>A0A2T6ZBQ0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1096285</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000443">
        <property type="protein sequence ID" value="PUU72920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBQ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBQ0"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="485"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU72920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="848" mass="94425" checksum="E1386F39666CBC84" modified="2018-07-18" version="1">MSSPAPQSSPPPEANPRKRGLEEDDDDEMGDNGVPSSPPGGFLPSTPGFRSSPPLMDDDDDDELDEHGGIQDLEDMEEEMDGEDLMQDMERDYTQNLVLDQYEDINIDDEGEHDELSAAEIRRLNKQMDMRDNMARRMPNAFYSIDEEDDEMDLSNQVRRRRHHFDEDTQDDVDNVMDEELSLEQLGDIKASSIADWLTVPNVYRSVAVHFKNFLLEYTDDAGSSVYGNRIRTLGEINSESLEVSFQHLAESKATLALFLANAPTETLKIFDQVALEATLLHYQDYERIHSEIHVRVADVPTSYTLRELRQSHLNALVRVCGVVTRRTGVFPQLKYVKFDCAKCGTTLGPFQQDSNVEVKISYCQNCQSRGPFSLNSEKTVYRNYQKMTLQESPGTVPAGRLPRHREVILLWDLIDTAKPGEEVEVTGIYRNNYDVQLNQKNGFPVFATVLEANNVVKSHDELAGFRLTEEDEKAIRTLARDDKVVDKIIDSMAPSIYGHRDIKTAVACSLFGGVGKNINGKHQIRGDINVLLLGDPGTAKSQVLKYVEKTAHRAVFATGQGASAVGLTASVRRDPMTSEWTLEGGALVLADKGTCLIDEFDKMNDKDRTSIHEAMEQQSISISKAGIVTTLQARCAIIAAANPIGGRYNSTIPFAQNVELTEPILSRFDVLCVVRDTVDPEIDELLAKFVVESHGRSHPVGNSSATPSVSGDRNTNSPIPQELLRKYILYAREHCSPQLHQMDQDKVSRLFVEMRRESLATGSFPITVRHLESIIRLSEAFAKMRLSEYVHSKDIDLAIAVTVDSFVGAQKVSVKKSLARAFAKYTLPKGGPRGPTTGAGRRARVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC48</accession>
    <name>A0A2T6ZC48_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC48"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC48"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="361" mass="40157" checksum="DF137FF24D23F4C1" modified="2018-07-18" version="1">MVSWSTIQTFLVLLGPIIYSRGKAFYQSTKLRGPPKALTPGTHRILNILFVTGIVALLSTLPTFAPENIFQKTGSRLQIPTDTLFHRLSKIRDVTPDDEILRARLASREARLTYANFGPKPLVECSWCSPEEANTYLFYALPTLALPHLLHIAVLGIVTSSYFSPFGSVWRTQATVAGLALFLVELYFVGVSTSDHDANALAKLPADIVWTHWRLNLWRGVGIAFVDAWLGYVIFLTGTGRWTAGLDGLQAQEKLETLNKASELVYAKLHSENFLRQTVLRNKDLREKSFEFWAAEERAGKEIMLDEEVKSVRANLTLNITQLTEGAAQKSEGMLNTINTWRGLPAEVPQTSPAQPLTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCA0</accession>
    <name>A0A2T6ZCA0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_576056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000413">
        <property type="protein sequence ID" value="PUU73089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCA0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="51" mass="5986" checksum="B8E36DA1F9C61323" modified="2018-07-18" version="1">MLSKCIESNILLYCRVVLFFSLHIIVSQELLCLLPVYISSLPFLWPFRQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD21</accession>
    <name>A0A2T6ZD21_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000379">
        <property type="protein sequence ID" value="PUU73401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD21"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD21"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="133" mass="14442" checksum="12D74BCAB3801721" modified="2018-07-18" version="1">MMKLISQTTTASISDRLVDSLWRKLSFASDATDEVLAYSRDEELRSSTFVAPPDESPLARGGLEESDTVHHTDGEDEVEDGIDETRNIWRGMAVRKYGSGGGRSIKRVKFSADVNKNGGAGLEGPVAVLEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD51</accession>
    <name>A0A2T6ZD51_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000387">
        <property type="protein sequence ID" value="PUU73334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD51"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="101" mass="11811" checksum="818972E50D2269AC" modified="2018-07-18" version="1" fragment="single">PAQRQPEGRYRPPDFEEAKHDPPFWLMVVVMCGCAFGLTAVFEEKLHPLIDLYVEGLTEWRPALSILCYARYLILLVISLTLCMLTADLWQCGFWFASWWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD53</accession>
    <name>A0A2T6ZD53_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_542850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000377">
        <property type="protein sequence ID" value="PUU73425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD53"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015735901" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10332" checksum="ACCD49B6BD9BB0B5" modified="2018-07-18" version="1">MTAVISFSFFPLMCGAWCEVVSLMGWGRKRRGDGEDGLGFVACAAASRCFCAVARGSCAMRHRAAPLWPVGCRLQGMISYYRTRAGDAATTIACGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDB9</accession>
    <name>A0A2T6ZDB9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1004403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDB9"/>
    <dbReference type="OrthoDB" id="2608216at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF149">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE TLH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="12471" checksum="C0B49825205CC888" modified="2018-07-18" version="1">MPTGAGKSTVFTVPATFREAKLTLVIVPLAALLDDMVDRCQKLGIRTCQWSDTTQDRRSLGSAEIVVAGTWTSKNDAFRTWVKKVSLDGWLDRIVIDEATYYTHKQHSDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDI1</accession>
    <name>A0A2T6ZDI1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000370">
        <property type="protein sequence ID" value="PUU73529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDI1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015711715" evidence="1">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12138" checksum="049C280FE6783E60" modified="2018-07-18" version="1">MPDLISTVALVIQLIALLVSRVRLTQQLQATGDTILAENLGRKWENKDRVPEDLTLAPVHVDVVTVVLLCLAAGMKFSRYSPATSEITMSGKVGAITGPLHPVLGALHVSTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDR2</accession>
    <name>A0A2T6ZDR2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Sorting nexin mvp1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1134843</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000361">
        <property type="protein sequence ID" value="PUU73637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDR2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDR2"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000037">
        <property type="entry name" value="Sorting nexin mvp-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000072">
        <property type="entry name" value="Sorting nexin MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="413"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="663"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU73637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="798" mass="88868" checksum="E5575414B3475E45" modified="2018-07-18" version="1">MSLFGDSPPGRSRSSLFADEEFESAPGSLFDDSGAGAWNSAGLPTARRGAPTDISKTLLTKENANIPERYNFLYESFLEQFRSPDGNGITLDGIKQVLKEADADGYGIEDKILSILIKGGKQSIGREEFYVLLALVGLEQQGEEVTIDGVDDSRRNLPIPDLAKSRRPHLSKGIETPTTSIASSINQSVAPPPHHSQSAQDLPTSSTPVKVVHRQQSTPISTAPTRPRNAAGIFGAESDPWGSPEMHANHDHANQPDNRVAIMDNSGKNRQPTPPMESNTYEYTPSASTLGMPPRDLSLDRNHSAYSHAPQTIQHIDDGDHEPDDIHSALRQSDASRTSASSWGVYDGSQRPDSFGGSTYNQSAGFGEPNPRMGQRHGSFGGLGGNSLNGSAPTITGADGGGLGRMRIPRGPEEVVTVTVLPEKEGMFMFQHRNYQIASARRQSRVVRRYSDFVWLLDCLHKRFPFRQLPLLPPKRLAVNGHYLSADAAFLERRRRGLSRFANALVRHPVLSQEQLVIMFLTVPTVFTLTLTELSVWRKQANLSVQEEFAGKALPSGLEEHLPQTLENTFDMVRSGLRKSSEIYIQLCNLVERLEKRQEGVAADYMRFSSALRSLTDASEATYAVDTSEIPLLNDGITAVAKHLSQSQSLIEDETKAWDQGVLEDLKRQRDCLVSMRELFERKDRYAIDNIPQLERRIKQNEAKLEALRHRVEPGKPGEEEKVQESISRDKKSIVDQHARGVLIKECIRDELIYFQNSQYHVARLHQDWTQERVKYAELHADNWRALCNEVEGMPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE22</accession>
    <name>A0A2T6ZE22_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000352">
        <property type="protein sequence ID" value="PUU73696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE22"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE22"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="132" mass="15269" checksum="6C10DB837D2EC84D" modified="2018-07-18" version="1">MTREHYPQRNEAEGTTIQIFNLIAGALGLVPHTQVRVVHKLSRHPEIMQKIREKLLKTDNTFRLDDSPRYNCRKNKYLIFESAVRETIRLHPAVSFSLSREVPPSGCQLHQYHIPPGYNVGMASYHVNYDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEY1</accession>
    <name>A0A2T6ZEY1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_487812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000325">
        <property type="protein sequence ID" value="PUU74057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEY1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="12337" checksum="64E78BE13ECA2C9C" modified="2018-07-18" version="1">MLTIFDTISFLDEIFLLFNCLRHQMSLLIVRQIFPFAFFACCVALHLFTLMFSSLYRCAVAYPVIILMTCIDLYFLFLSSFCPVPISPVLLAYSFPTQSHDCPSNWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF76</accession>
    <name>A0A2T6ZF76_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000320">
        <property type="protein sequence ID" value="PUU74158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF76"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF76"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="328" mass="35560" checksum="950E6CC30948A45A" modified="2018-07-18" version="1">MLPPISPETLSTNPLFSTLYTDLTTNHLNPDASTRPLPPPPSHHSQPSTFSTLDQSLRTYRAELAKQHLLQNSLKYTTLRSRQLPEDLSEVLDLLTFSTSTSTQGINAGQLEALGVFHDNIQPIAHEISAFLDRSAKDLVSLLQPEQPNAGAGVAGIEIAIAIDHLPANAARLRTQIFANHQSLVAQRGRLGRLILEVVDGYATLSLRTLSHSASDGGACGALQKGTLAKATYLALLAESMRGKVGVVRFDALGEVYDEEAIGALENYRVHLTDTNLRLVARKRVVEGELERYGAAGTDMVGLVERYAALLREIESVGRDIRRLGGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFC0</accession>
    <name>A0A2T6ZFC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1133756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000317">
        <property type="protein sequence ID" value="PUU74191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFC0"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="26845" checksum="7D781EF51BB01F78" modified="2018-07-18" version="1">MDRMGASIPLIYHILGIISINDHLIHSMTVRQVYFLTFMSLDIVTTQGKEFDIPHAKGIIAGSVGVLWPTRLIRPILVRLLSTYSTFTLDTPDPITSIAPPDSTISPYVMHTPRLEITTTHILYATMATQRTSSLASLGRSFPFALTTEIGTVDDSVVDRIGLVLWDSLAMCFPGLEKRRHISPDAGRVRGGNGDGMSIAWEETVTRILGVKGGVWVIEEMDVTVERVERTKGLKEFVGIFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFN5</accession>
    <name>A0A2T6ZFN5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000310">
        <property type="protein sequence ID" value="PUU74266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFN5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="51" mass="5958" checksum="F88CA1D25525B020" modified="2018-07-18" version="1">MLRYMYIILHSRCVSYVTVPAGVRELLERECIENTLSGQSSLTERKPERTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG23</accession>
    <name>A0A2T6ZG23_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_451189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000300">
        <property type="protein sequence ID" value="PUU74422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG23"/>
    <dbReference type="OrthoDB" id="5367316at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015601505" evidence="2">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="274" mass="29157" checksum="2DF7E2FCD3D641A9" modified="2018-07-18" version="1">MATSFFTFALSIFPLLAQAGPSCPSGSELTTRITKFVIGATPDRVFDATGDFFNAKWQGVPQDRTSNSPSRRTLAFDSVQFVEELMSANVDRTNKVNSFSVNWRLTDSVTFAAAAVQVRIPYYEQYFEIEPRCNGSTHSTGNWRSCLCVSGDSSKDAATEWFEARHRSAVQNVFRELGAQGWMEEQINGDIPGCGAAVTAAIAPPSSTSTSTSASSTSSISPTTSPTTAPEPVPQAAPGQTAITSERKTAGGHKGKADAMFALAIGGITVSIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG51</accession>
    <name>A0A2T6ZG51_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1092747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG51"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG51"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="9034" checksum="8C6F679CF17DB63A" modified="2018-07-18" version="1">MIRQGNKWAHGGDAVVECLLYRGIRPRNDPYDFELLYGFLPPVVECLRKQETINALNIYATVQASDRKYGTESFYQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGQ4</accession>
    <name>A0A2T6ZGQ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_901143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000280">
        <property type="protein sequence ID" value="PUU74678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGQ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGQ4"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="139" mass="15517" checksum="720BF43C6EB29AD4" modified="2018-07-18" version="1" fragment="single">SYKLVRNRFISTFKRDKLGLVTKEDRRIIAKGNSQAHGGDAVADARLYEGTARRSDPGDFQKLYGLPPTVVSNLTHPETVKVLNCHASVIASDCKKGSPIFYHRFATFIKLFVKSGHDPGYLDGKRTPVTDAYWAFLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH42</accession>
    <name>A0A2T6ZH42_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_998270</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="NESQ01000272">
        <property type="protein sequence ID" value="PUU74813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH42"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH42"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="346"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="563"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="792"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="812"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU74813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="826" mass="92406" checksum="3617AF269177BD59" modified="2018-07-18" version="1">MPPKRKAGAAGGTAAVATTSAATKRSRPATPAVDVDSSDEYSGDEEIENTEEGRAISKAVNAFSLDLVPKGNDVIAKRDSVSYIFNKQDFSYLKMKLDHESRPLWINPESGVIVLESFSPLAGQAQDFLTTIAEPLSRPTYLHEYKLTPHSLYAAVSVGLDPNDIISVMDRLSKIPVPPKIIDFIKKCTSSYGKVKLVLKENRYFVESSDPAMLQRLLQDPVIGPLRVQGEGGSGITKEKAPQMGALVIPGTRNAAGAANVNNPKGGRPVEVAGDAAEDLFNSDAVHSFEIPADDVETVQKQCLDLGYPVLEEYDFRNDRKNANLDMDLKPQAQIRSYQEKSLSKMFGNGRAKSGIIVLPCGAGKTLVGITAACTIKKSVVVLATSSMSVVQWRQEFIKWTNINPDAIAIFTSENKEKFRGDAGIIVSTYSMVTNSRNRSHDSQKMMDFLQSREWGLLILDEVHVVPAQIFRKVVHSIATHSKLGLTATLLREDDKITDLNFLIGPKLYEANWMELAEQGHIAKVQCAEVWCPMTPEFYSEYLREQDARKKVLHYIMNPRKFQATQFLIDYHEKRGDKIIVFSDNVYALKAYALKLNKAFIYGDTPQQERLRILENFQLNDQVNTIFLSKIGDTSLDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTAEMYYSSKRQAFLVDQGYAFKVITHLQGIEQLPSLAYATVAERKELLAEVMLQNSEAGQQEGDDFDGAKLSYNAGRKGTRYRRTTGKLSELAGGDDMAYIEYNRSRNKDLKGKGQSSAFFKKMHRENEKRRKEQNALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH57</accession>
    <name>A0A2T6ZH57_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mis12 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1091758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000269">
        <property type="protein sequence ID" value="PUU74830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH57"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH57"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="341" mass="37581" checksum="FC202292AA750422" modified="2018-07-18" version="1">MNPASTSLLTEHLRWTPLSLIDDIINTVNALLYQSVSAVETFLLSSPPGLLGFTPPSGTIPDTDGDGNVIYSEKEQEEINKGIHQLETLLENGVDKRFDAFELYVLRNILVVPQDLVGWVRLAHHKNLDFTSVTPSAPTDPNSSEPTENTPALPPAHEAQSRLRTLRQTLLASHALNQTLQSEVSSNERTLTQLRALANSSDNKNPFSFINSSSMSTKELKDTASFAVSQIGLIRSLIAQLKPKYAELQRQRQKEQEEALGDKMDVDEEIGGKEEKGTPEEERKKYIEKMTRRHMESSRGLRLNAKGEVVGGGFEENVARKGLGEVGELEGLVEGLGEGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHG7</accession>
    <name>A0A2T6ZHG7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000261">
        <property type="protein sequence ID" value="PUU74922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHG7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="106" mass="11651" checksum="EB45AAB51930C0C8" modified="2018-07-18" version="1">MPAMPAMHAKPTPQADGYSTPAHSSQPTLEPERLIDANPTPPESSLTIEPEGAPDMHHHPTERLDGVEYYEYRDIRPSKEAVDTQAKAFGSPKADESPSLYLIFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHR9</accession>
    <name>A0A2T6ZHR9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Nucleoporin protein Ndc1-Nup</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1103132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000254">
        <property type="protein sequence ID" value="PUU75035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHR9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHR9"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU75035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="335" mass="37772" checksum="5FB080EB17EF3F4B" modified="2018-07-18" version="1">MVSSISRSIPSSAPPRLPPPHYQTFLTPILHRRFARACLVGFAACYLEAFVISNKSSLFWAIFPIGWTGFKAIILFFLSVFPILTLRISQLHVGARSHATVFHAMKAYIGSFSTYSTFLTHSFASLVFVFLYLWSGSKEDRLRFIIEGKSYERPRLNERFLYLIFFACYTGFIQAALHLYEDRGRLQLPHLYLSPKAAFKKKFLEVPSGALHMALLSACTAPFAYMPFRGVIWQYTLATAKTFYWLNRSSTLPSFPVGAGMFIRSLWLSFLIGVMWQISNIAFDVYFTQKPLSADGKTISEKSPDPNGTLISGLKASPAPLTQVCSCITRLINVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHY1</accession>
    <name>A0A2T6ZHY1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1031526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHY1"/>
    <dbReference type="OrthoDB" id="3596604at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="746" mass="82709" checksum="8C6C229A115C4D54" modified="2018-07-18" version="1">MSSSHSDSYHPPQYNDAGDPLISESEKLPRPPSDDADDPLISKPEESSRPPGGADDPLISEPGEPPKPQISFDSWEQFQWHLINLSGRCLTTALSLSLLILGLLFFSRMGVLSKLEQYAFNAITILLGAFASLGLGSLLEYLGSMMRWRLLAMTKYKMQDIELLLGMTSPTGAAMLLYTHFREWRLSKTTSIVMLYLFFNITGRFSVAIFGLTYNVLNDPDTRLPILTTNWSSPDCCVLSANVAVNFEEAMDGLRSYLDLSEGGLATLTQRPMIEFNISAPQSLDDDTYEDLAVKGSNIYKVGSGVELAYNITDRDGIDPIPSGRTVRTGTSCTIFRLNNRGYWRDYDGGNQTWTDWTKESNTESIATVLRVLSKENAWPQWGVELATWATPVLAARRPTTPSVTYVVYNETAWECNSTLSEWEGGVRSPKPLFDSATLFLFPIASGLKFANESQSGRTKIITRTRALIGHVKTYTETIVSMSTARALVRGENNDLPRTTPAIGIRAESARVQTTTIVQTTTSTSFSTGLRTRTITQEPTMEGSTASVAYRLFTELQSRTSPSVGVQTLNFYKNGIPLPIEQKEFYNRYVATLVARLPIAAIAFGNQVCSRMQKDPKARSEEDVKTTVDVDWSRVAAVAVTIVAAQVLAIIAVLYYCRNIYVREDGFIPTAELLKTVLGKIEDGSMMTGEELENALDEVLGGPVSYGTIPGLEGDYPRVAFGREVNYFFPKFPDSPQFRKRSAFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ65</accession>
    <name>A0A2T6ZJ65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dak1 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1030774</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ65"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ65"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="9"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="394"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU75530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="590" mass="61737" checksum="12F12ABDBF98CB48" modified="2018-07-18" version="1">MSNKHFVNDPVHLLNLALRSAPLTNPSLALDEENKIVYCKSSPESHASRVAIISGGGAGHEPSFVSFVGDGVLRAAVSGSIFASPSVKQIYSCITRRVNPNSGVLLIIMNYTGDVLHFGLASEKAKAAGVDVDMVVVADDVGVGREKNGKVGRRGIAGTVLVHKIVGALAATTAGASLKEASALGRLVAANLVSVGSSLTHVHVPGRAMTSDDDEGALKPDEIEIGMGIHNEQGYKRIKIPELPELVKILLGQLLSKEDKDRNYLEDVENIEGWVLMLNNLGGVSPLEMGAITAEVAKQLDSTYSIKPKRIFSGAFMTSLNGNGFSISLLRLVDTGLGKAKSMLDLLDAPHESLGWSAPIKQETWANAGGQNQASESDAKEESVPPSGLKLNVNQFCHALSNALKALIKAEPEISRYDELVGDGDCGSALKKGAEAILQLISANKISPDAVITISTLAEAVEANMDGTSGALYSIFLNSLAKALREAGEGEVTLGVWAKAAMAALVSLRKYTPAQPGDRTLVDALQPCLISLAEDGNVGKAAKAAREGAESTRRMKASLGRSVYVGDVGDIPDPGAVGIAVLMEGLAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ94</accession>
    <name>A0A2T6ZJ94_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1090081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ94"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ94"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003472">
        <property type="entry name" value="GTP-binding nuclear protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="129" mass="14859" checksum="173FFA253AC039D3" modified="2018-07-18" version="1">MFDVTSRITYKNVPNWHRDLVRVCENIPIVLTGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPTLEFVASPALAPPEVTVDTEVLAAYQREMEDAAQHPLPDEDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJZ6</accession>
    <name>A0A2T6ZJZ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1089661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJZ6"/>
    <dbReference type="OrthoDB" id="5380764at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="13764" checksum="4319F080066AC85B" modified="2018-07-18" version="1">MASILRPSSDVNARGRRLRIYGPSRLQGLPHNRSTREDIIMFFQQIPGGIIRHADFHKYYPKHDGLSSSKRMQNFEALWKSCTIWLPQYEAYILNPACLPGKDATLSDECTSVNDILSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKA7</accession>
    <name>A0A2T6ZKA7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1089578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKA7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKA7"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="172"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="285" mass="32055" checksum="4CEA0024FCD8CD4F" modified="2018-07-18" version="1">MSPPAQIPDYTILPITLAPTPLVGAATHYLYLRKHAPKQPAPDDPRSLFVVNVPIDAQTAHFRALFSAIGGGRVEKVIFEGEASITCAIGKRKRGCEDEDEDGGRGKVWDRQLRQSGSTAVVVFVDKSSRDLTIKAARNFSKKSPVWGAGISEDVNIPALGISRYLTHHNLTHPSKAHLQASVNTFMTAFEAEETARLRALAKRRQEPDEDGFITVVRGGRTAPAQQEEAKAALERKKGKEKHEGFYKFQVREERKNRQMELLRKFEEDKKRVAERKNLRRFKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKI8</accession>
    <name>A0A2T6ZKI8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="14" type="ORF">B9Z19DRAFT_992275</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU76001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKI8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKI8"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU76001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="452" mass="49747" checksum="4E341F2B6F6CD6A5" modified="2018-07-18" version="1">MSTPVNYLIPRQKDELHKAILAYFSASGLSNTGAALREELGVGDEFLDQNTMKKYEGVLEKKWTGVLRLQKKIMELESRLSSLQSELDSTTPTSLTRRNVDPSSWLPRAPAKHVLTSHRNSINSVAFHPIFSVLASGSDDTTIKIWDWELGELERTVKGHTKAVLDLDFGGPKAGVLLVSCSSDLTIKLWDPNNEYKNIRTLTGHDHSVSAVRFIPSAAGEYLVSASRDKTLRIWEVATGYCVKTISGHSDWIRDVEPSHDGRWLLSAGGDQTTRLWDASTAEHKATFLGHEHVVNCCVFAPPSAYPHLATIAGLKRPPPATSSSEFIATGSRDKTIKLWDARGTLLKTLVGHDNWIRALAFHPAGKYLLSVSDDKTIRCWDLTQDGRCVKTVDEAHSHFATCLRWAPAPAKEQTNGEAKANGIPKTGEKVINVRCVIATGSADMNVRVFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKV9</accession>
    <name>A0A2T6ZKV9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1066908</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKV9"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000009">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000003">
        <property type="entry name" value="Threonine--tRNA ligase 2, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="84"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="352"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU76113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="744" mass="84576" checksum="8E0F937E5C2E7CA4" modified="2018-07-18" version="1">MEKVSEVAEGVKKVALGEGSGKLTEASQALRHPKADKKSKKAAVSATTGPLELEPPPEYISHRIQLFEKLKAEYDQEVAAKPREDILISLPDGKTVAGKSWETTPASIARGISKSLFEKTVIAKVDGSVWDLERPFERSGTLELLDFEDPEGRRVFWHSSAHVLGEAAERRFGCHLCLGPPIDDGFFYEMGLGEGEVVTAADYKPLETIAQKAIKEKQPFERLVVSKENLIEMFKHNKYKQTLIGSKIPDGTSTTVYRCGPLIDLCVGPHVPNTGRIKAFQVMKNSSSYFLGDASNDSLQRIYGVSFPDKKQLEEHKRLLEEAAKRDHRKIGKEQELFFFHELSPGSCFFLPHGARIYNTLVDYLRQEYWKRGYEEVITPNMYNAKLWETSGHWQNYKENMFTFEVEKDKYGLKPMNCPGHCLLFGHRERSYRELPWRVADFGVIHRNEFSGALTGLTRVRRFQQDDTHVFCTEEQVGSEIHGLFDFLKTVYGLLGFTFKLMLSTRPEKFVGDIATWDSAEAQLTKALDEFTAGGGGKWEMNPGDGAFYGPKIDVTISDALRREFQCATIQLDFQLPQRFKLEYNTGEPSAKGQDGKDEMGHYKRPVMIHRAILGSVERFFAILTEHFGGKWPFWLSPRQILVVPVMAAANDYVLEIQKLFRAKMMHVDVDIGPNTMAKKIRTGQLQQYNFIFVVGAEEEKSRSVNIRNRDNKETQNKGELVPIDMALEKLCALRDERRVVNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLN4</accession>
    <name>A0A2T6ZLN4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1088402</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLN4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLN4"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU76334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="510" mass="57079" checksum="7D834BCE2886D6C3" modified="2018-07-18" version="1">MNAHIPQSTYSPSLLLVLRRSSQAPQCRRLPSSIRGQSVISRRSYSSTLPPIAHKRPAAATVEAGCSRPWVTSSRMSSSIIEALFGKRVKKGLEREAGISSRYLDSGTEDAILGRSLLHKNHNDQFLRCTEFDREGNVTVVSGEFKKNELCAKHGLMPRDLRKLWVPSIIVPHILVRKNSILVNLLHIRALIKADTILLFDVYGSTDSYTQSVFMYDLEGKLRQGSKAMGGLPYEMRALEAILISVTAALEAEMKVLQELVITLLEELEEDIDRDKLRQLLIYSKKLSTFEQKAKLIRDAIEEILEADDDLADMYLTEKMLGKTRPKEEHTEIEMLLESYHKICDEIVQISSNLVSSIRNTEEIVNIILDANRNSLMLLDLKFSIGTLGIGSGTFIAGLYGMNLKNFIEESDLAFWGVSGWAFIFSAIICAYGLHKLRRTQRLTMWGESGAKEGKRGWLSLGNKKTGGSAAAKAKLAGRFDALQKRRFGHVVERSPSSFPPLQLVPAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM60</accession>
    <name>A0A2T6ZM60_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1028627</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000183">
        <property type="protein sequence ID" value="PUU76577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM60"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM60"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="510" mass="57274" checksum="DAC3F649C491ED84" modified="2018-07-18" version="1">MDEELSRFRQQWQAEVSVRHHQAPGPSAPQSASSVNKQNQNPFASRKLSHSSSTGEGVEDESSELSAQRPPSPIAHRRTSLASSALEHYERAVEKESEGNLGESLNLYREAFRMDHKVDSYWREKHFPRLPPLLAKKMTPLTTILSSQPSVPASAPASASLASGSKDMSELIASFAGVQIQPAPVAKLNEDKGAVDKGKGKEIETEEEEAGVSPLATLPFELLLQVIRNVALTDIASFARLAQVCKAFAYLVITEQSIWRAVCEKTFDRMIWDWRVTVKGDPIEKPHVLDALRDGEYEAEDEGQEKREIPIDEKEVFKYGESWRKMFMIRPRVRFNGIYISTCNYVRAGASQSWGTSKSWNTPVHIVTYYRYLRFYPNGTVLSLLSTCEPAEVVHGFNKVSLTPAHQGGLPVGAMSWGKYVSKGRWRIDKDGQLDVETEAPMMDKYLFKMALKVKSVRAGGRVGGVNKLVWEGFWSWNVISDDLAEFSLKNDKPFFFSRVGSIEREMGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMF5</accession>
    <name>A0A2T6ZMF5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMF5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16802" checksum="2DAD41D3363734ED" modified="2018-07-18" version="1">MLPQFDKRDNSENQEHNSNSMSLGEILATVIAALTLLVATIPLLRCSRFRRYVYSSISPFVKKILRIPPPDPMPIATTIAEDSSATLAPEIPVPRPVFICNHHPNAHLVGTCSTTFPYNRNGIAGEDGRVLQVKEPQAPRRPERTVTYPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMI1</accession>
    <name>A0A2T6ZMI1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_228583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMI1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMI1"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="263" mass="28912" checksum="E582C03E2D32AC56" modified="2018-07-18" version="1">MAATFKPPQELPYGRAHPLQTLDLYHQNPDPDAYWVVFIHGGAWRDPKMTKSSGHPFIHSLLSKYPHLNAASINYRLSPHPLYPSNGNVAKHPDHVDDARLALSFLQERYSMKREKSVFVGHSAGAYMAFQIDAGCGAAAAVVVGVEGVYHLGKLVEEYAGYEVLTEGAFGREWKEVDGEVLVEVEDGGRGGGRVVLMHSSQDELLSFEQSRYWAGVLRGRGRVVREVYDVVGNHSGVLEGVELVEVVEEELKGLEAEAAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN15</accession>
    <name>A0A2T6ZN15_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000171">
        <property type="protein sequence ID" value="PUU76877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN15"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN15"/>
    <dbReference type="OrthoDB" id="5408302at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="704" mass="74105" checksum="1017C7EEF4F6B183" modified="2018-07-18" version="1" fragment="single">GNLGTGTLQPPLIHTSHFLYQLSVAASTTTTDLPTQRSPLDALPSISSGSPGLGSSGQWLVEGTAGSLGPGTSYSLHVSEPIHAPLPPPLPRPRSRSSKPSSKPLSTKPAPNTKLAALTAQPSSLAAPVDGSSSHHNLSSGSSSSNNAANQGVGIGGYPVSTMITSSYRKKTKLTLLNPMSLLMRRRSPQASGLLSDSAKTRNAKDLPGDFDPGIIYGTRHPDWSNPPKRGQHEAVRPPVDRNPLMDPNNKLGIGDREYFDDGVGQDRGSMVGKVGKRSHLGVEHCLPLLCPRMKETSTMGNLVVSLLIIRYSALRRINQRSRHIRTIEFDGDGTTTGDGIAGYGDDDDDLYFDDGIILNNPTAQSSANNPGQEEGVEKSMNKEQRDSFPSTLGISSGGAMQVEYGSLDSLTKDSNDGTAGTGGGSGYGNKSFPPFLNPIGAGLGCTQQAQFYAPDGTMLDGHTGLPLALSTLTQQLYQYRKRQQREAEVAVANEINSPGALSGIGGGGYYSIDDDEYEQENADDSMDNAFAGRYFGRPAELASRPTIRKPCLTPISERSESSYRNREDIGSLTSSNSGGGEITREQLMHLRRDAWGGSNGSLRSSRGSGTHSPVPANSMVGTPPGLSNAGKNEMLPTKTSFQAEVATTESGSRNGRSTADGSYASAVGSPIGDYEVMDAEDGNGGREGWGFSPIIAAAASPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN56</accession>
    <name>A0A2T6ZN56_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN56"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN56"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="25383" checksum="6911B82B735BD1A6" modified="2018-07-18" version="1">MATTITPVFADEGQGKKSIYDIHPGYSHTATPASLDTKSPRLIEATPTTAPEPTDEKTTPTPTDRLAAEIRKARLFLHEHTVHLQKHVDLAFSKYLSYEHSITTTISSLAPPKSSEEKVVPGVLYVAVSTMAGSIMARNRMFPIRVLTPVSVGIGAGWYFLPETTRNVADLVWEWEKTVPEVAEKHLLIRRKIEEAVEVSEKAIKDGRKVVDENVSRGRSIVEGWVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNM7</accession>
    <name>A0A2T6ZNM7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1086950</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNM7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNM7"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015371176" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="13"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="344"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="481"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="394"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU77075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="548" mass="59444" checksum="3B4BFF65E7587512" modified="2018-07-18" version="1">MKQFKELTAAVLTLLATVAYAQEGEAPAGPSDVNVLGKGNFTSFVTEHPLVLAEFYAPWCGHCKALAPEYEDAATKLKEKEIPLAKIDCTVEAELCEKHGVQGYPTLKIFRGPDSSSPYAGQRKSDAIISYMKKQALPAVSILDGDTIAEFKTADKIVVVAYLSADDSENSATFTAVADKLRDNYLFGTTTDSALAEADGVKAPAIVLYKTFDEGKTVFDGAFTTEGITNFANVASTPLIGEVGPETYTGYMAAGIPLAYIFVDGEEIKEKLTTAIKPLAQEYKGKINFATIDAVAYGAHAANLNLETKWPAFAIQDTTKNLKYPFDQEKEITEASLAEFVKDFVEGKVDPSIKSEPVPETQEGPVHVVVANNYEELVMDNDKDVLLEFYAPWCGHCKNLAPKYEELAALYFNNPEYKDKVIVAKVDATANDMPIEVQGFPTIKMYPAGAKDSPVDYSGSRTVEDLATFIKTNGKYKVDAYVAPPPEPETEEEEEEAEESKAEKSAEETPVGSAAPAATETPKETVKKATEGAQAVVGDDDYLPHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPE7</accession>
    <name>A0A2T6ZPE7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1101907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPE7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPE7"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="109" mass="11850" checksum="474A494D23281A03" modified="2018-07-18" version="1">MAPTKKTKKTADSINTRLALVMKSGKYVLGYKSTLKTLRSGKAKLVIIAGNTPPLRKSELEYYSMLGKCHVHHFAGNNIELGTACGKLFRCSTMAILDQGDSDILSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPI9</accession>
    <name>A0A2T6ZPI9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_175316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPI9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="19091" checksum="090440832AAA4DCE" modified="2018-07-18" version="1">MGPLSSSSSRALVPYQALHGLKEWGVSLIETEELFLAIILKFTKLGGILAEMGRYGLIFTQDELSGFLNCCRSSENGSEISQFPASTPCYAPQGLGLMTKSTWQPIVGEFIIYLLLLFCVRASDSIKLNSSDYYSIHTTKYSISQDLVDTKVLVLNKRGHWSVLLVMIIMAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPK4</accession>
    <name>A0A2T6ZPK4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_987042</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPK4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPK4"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU77418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="308" mass="35224" checksum="C9C1FD6EDF0C826F" modified="2018-07-18" version="1">MAPGLTSKTPPPHPSGRELEEVSDQIDAINILLSSPTPTTTTTTAGDSKPKSNFRQYLTAAPQVKALYKEQHEKQTVEYNLAARKAFHLTVRARMGIWEAMEKLNALIDESDPDTSLSQIEHLLQTAEAMRRDGKPRWMQLTGLIHDLGKLLFFFGAQGQWDVVGDTFPVGCAFDSRIILSESFTQNPDSKHPIYSTEMGIYTLNCGLDNLLLSWGHDEYLYHVVKGQSLLPAEALAMIRYHSFYPWHREGAYKRFMNEKDWQMLEAVKEFNPYDLYSKSDAPPVVEELKPYYTELIDEFFPKKILDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPN4</accession>
    <name>A0A2T6ZPN4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_987167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPN4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPN4"/>
    <dbReference type="OrthoDB" id="2017782at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000167">
        <property type="entry name" value="RNA binding protein Jsn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="344"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="498"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="4">
        <location>
            <begin position="562"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="848"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1077" mass="115648" checksum="441DA3956E07103E" modified="2018-07-18" version="1">MNPISSYQEPPAIQNDYASTVHRRARAGTVPSRFSPGGFTTAPTIIPGIPSTSRPSPAPSPFKSNSPQNVEMVDNGPVSVAQSSSSVASRLRSGSLNLPPRANYVSPFGPSIFASSWTPGRPTAGGNNGLPSSPAHSSFSKDDEGTHMAPKTLDYLGLVDSPQAARATLAKPMGLDTLIEGQRAAALQPFISELAGIQRSNRIRSYSVNAKEQYAEDEDEEEEEEEQRHLYSGQQSGNVTPSSQANLAAQAALHSLGVPFSPSRPRARTAGVLDSPPVNRLKSYLATPSRLDSMTSAADIGRDYFDLANSSDHTLKLGNMHPRPSSGEGGLASIEESSLEGPTRSLWLGNIPASTTTTSLVHIFQGFGNVESARVLTHKNCGFVNFNSIDSAVQARSSLNGKEIFPGAGPVRIGFAKPSSAGSNGTPTPNGGAYGSPSPGPQGDSTPSAIGDGALSRDANGAASNGSDSRDSPAALKLPDLIDMREDIVKIVQEFGAEREDALMVGANIDKAVEYQDFEPEIPPIPEPTHNRVHDAPKLRDIRKRIDNGNCSQTEIEEISMAMLDEIAELSSDYLGNTVVQKLFEYCSEEIKEAMLVEIGPHLAEIGIHKNGTWAGQKIIDVAKTPAQMQKICDCLRPYTVALFLDQYGNYVLQCCLRFGAPWNDFIFETMLSRMWEIAQGRFGARAMRACLESHHASKDQQRMLAAAIALHSVQLATNANGALLLTWFLDTCTFPRRRTVLAPRLVPHLVHLCTHKVAYLTVLKVINQRNEPEARDTILKALFFSPGDKVLEDILSDHSCGATLIFKVLTTPFFEETMRSEVVQNVRNVLLRLKATPSQGYKRLMDEVGLPTRNGVSNNTNTSNGPKDHPRDGVNNNSNASNDRRGASQNSPANHNHNHHNNNRDLPPVSFYNVPPSGFDPAALAAAASQMPQNGGFDPVALRAFEQLSLTAGSLYGTPGPPGINNPALQYQALLQQSMGRPGPNFFGMPPPMGNYNGGQASQDQYRAGHTGSSPVPQPQQMANNPMLGGMGGTPGVFNPLQLMTGYPYGIPVFQPPQQQGNGAGSGRRGGRVSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPN5</accession>
    <name>A0A2T6ZPN5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPN5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPN5"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="11945" checksum="62D379CDFC0E17E0" modified="2018-07-18" version="1">MARDMEGMVDNFRTSEQAGMRKVLSAGFGPSRKFVGTCSGSVGGAGSEREWRRERTAGTVAQEDEEGEGSTIARAEEESVADEGTEKETENRGGGGQEGKRKIRRNKKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPN9</accession>
    <name>A0A2T6ZPN9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1027153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPN9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPN9"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000012">
        <property type="entry name" value="Rhomboid family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="191"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="356" mass="39792" checksum="E74DC30ABC1E64C0" modified="2018-07-18" version="1">MLHLFTRSSTTILLNTSKTTCLQSASPSFGIRILRNQRFKSRFFHRSSFKQFPNRKPPPRSGKLTLEPATNPSENLPSAPQLKLLDRLKAQGQLSQDEAPRDLSHSQRLFAPFIFTLAVCGGSYYFASTWTPPPLDARMFPALPQSVTTVAAIIAANAAVWFAWRIPLPISWRFLNRYFLCAPALPYSVGLLGSVFSHQSLTHLGLNMFALYIFGSTLCDQIGRGNFLGLYFSSGVVASFASLTHNVLRSRFHVYALGASGAVFGVLGAFTYFNPETKLTFIFLPFVALQAKYFMSGVAMLEAFGIVRGWQTIDNVAHLAGLSWGVGMAYWLEQRVKRRRGLEAAMARERASKRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQA4</accession>
    <name>A0A2T6ZQA4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">STAG domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1065668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000145">
        <property type="protein sequence ID" value="PUU77678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQA4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQA4"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="404"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="643" mass="71479" checksum="62B2ABCF37A828CF" modified="2018-07-18" version="1">MDTSDDNAVGAAETADENASTTAGAAAIPAGDNDDTQNSAKTGNRRRSTRVIKKPALPYSSEPSPPKPSRGKRKRPLEEEEEEEQEREDGGEKGSGGENEEDESANDESEDDGDEGGRTESSEEDEDEGEPDEEEKKDRRRRNAAARGAGERGGSAPFKKPPTKKPRTSVITSTAPPARKTTTEQAKRVKGKAVAKPPPKAANGDDDNEEEEGNRRIMISTAWTIKYEENSREAMKELVNFILKCCGCHKFVTDYDIEDQDTANTTLSQIQEAFQQPEFRRFRPILASFLHSLITIFAARELLYSDPGLMEGIEVWITAMSSSTLRQFRHTSTIVALEFVSCLAQIAAEVRKANSTTNRQLEAEKKKSSRNEGRIRALDQKLKDGEERREGIETVIKDIFNIVFAHRYRDIDAKIRSDCVRELGSWILTLPDLFFDGSYLRYLGWVLSDTTLQTRLEAVKALTKLFKKKELISKLRHFTERFRPRMVEMTARDADTNVRAAAADLLDAVREAGYLEPSNYTTHLRSPFSTSCIFSQTSPQKVSRAVKLFTDNQCKFAIRGGGSFCRSRAANTNDGILIVIEGPNKDTLTNEDSVWLSAGLAWSDVYGYPGPYYKSVVAGCYYPVGTGLLFGAGLSFGSERPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR24</accession>
    <name>A0A2T6ZR24_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1026156</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR24"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR24"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="6">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29989" checksum="63A11441392A18E3" modified="2018-07-18" version="1">MSLAVHFPGETLPPLEEDEKKNTTFKVGPGLTHILPSTLIVNRAGELNIDQRKHTIWMESNGKRYVASQNDTIIATVLRSTSDSYICAIPSSNSPVSSTSQAVLPHLAFPQATKKTRPMLHQGSVVFARISLANKHIDPELECYDADSGKAEGFGELKGGFVFGVSLGMARRLLGDAKKTRLLRVKQRRAEAERRGEEYQDAGADMSSGKEVLEELGQNLSFELAVGRNGRVWVHSGDPKTTLCVMRCIQQSEFLTGKEQRQLAKEALKALGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRL3</accession>
    <name>A0A2T6ZRL3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1065335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRL3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRL3"/>
    <dbReference type="OrthoDB" id="5597238at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015787303" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="16943" checksum="B7B545C2B20D7052" modified="2018-07-18" version="1">MKFSTVFISLGFAALAAAQANSTRAVASPTQTSSYSTAVASCLGKCKEADVTCRAQCLGSAAPNDGAANATNECVAKCPKGDGSQAQTDQYAACANSCINTIFLSTSSVAPAATGSSGSGSGSGSGGNSGNPTSSGSKPSGTGSSTSSSSSGAPNAGSSVEAGGSFLLLLGMAAGILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSA8</accession>
    <name>A0A2T6ZSA8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1084299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSA8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSA8"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU78379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="342" mass="36886" checksum="1A036AA6310A001B" modified="2018-07-18" version="1">MEFASLTLRQVAEAEGSVPKCGGGNEYDGKMGLRISAVFVILVGSMFGALFPIIGRDHPRMKIPEWAMMFAKYFGSGVIICTAFIHLLTPANEALTDPCLTGPITEYPWAQGIALMAVFTVFFVELLATRFATFSTNHLGYDIDNSSSSEQAKEHCDSSPSARAGDPEALNCAEAEIMKENYAAQMISLFILEFGIIFHSIFIGLTLAVSGKEFITLYVVIVFHQTFEGLGLGARLSTVPFPNKWVPYLMGLGYGITTPLAIGIGLGARSTLDPASQTALMLNGIFDAISAGILLYTGLVELMAHEFLFSSTLKSAKISYVMMAFVFMVSGAGLMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSY5</accession>
    <name>A0A2T6ZSY5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1114860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSY5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSY5"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000149">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="39"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="303"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="469"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="339"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="420"/>
            <end position="421"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU78610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="668" mass="74450" checksum="24DF5EE6AA95641A" modified="2018-07-18" version="1">MDAHQPTDPGAPIWYIGNHLPTPDLTISGQTLEDEATQGYDMITTFITNTNFRSRINQILLNAAAEKRTHMKIDSLDAEEVTVHPGDHISQVIGFASPWLEFDSDDSLVSHVSKQALLYELDYAGFCGIGNVVISGPRRKENVSQFAQVINTVLSASGYAHLLILLPLAEKPSSAVEGDKYDEFSAWDTWNTIRTVCKYNSRLSLALQIPAELPTLHVMDRWFAEPIRVVLLPSSTFSPNPTGYPALSKNHQALLTKYTKQRPTPYILLSDQRAASEKVRYEPLSYLVYIRHLQKNQPPQSTVEKYGSGYQDYLQTPLQPLADNLESITYEVFEKDPVKYDQYEKAIKLALDARDAASNTVVAVVGAGRGPLVFRALRAAQASGRAIMLFAIEKNPNAYVHLLRHNRDTWNGQVTVIKSDMRSWNPPFAVDILISELLGSFGDNELSPECLDGVQRVLNPSGGISIPASYSAHFTPIMAPKIHADISSRKNDSEAAETPYVVMLQSFEILAEQGYIHRAWEFTHPLPPNVLSDSTALSGGLIGLGDGGNNHNARKCKATFKVPRRGVVHGLAGYFESVLYGDVELSTRPDTIDMKSKDMISWFPIFFPLKTPLHVPDNCELDVCIWRQTGERKVWYEWVVEAFARSGGQRYRLGVTDLHSSKQNGCLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUL7</accession>
    <name>A0A2T6ZUL7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDP-alcohol phosphatidyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1101061</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUL7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUL7"/>
    <dbReference type="OrthoDB" id="10020554at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000017">
        <property type="entry name" value="Phosphatidyl synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU79104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="31841" checksum="3BE529D5758BC535" modified="2018-07-18" version="1">MLGRQQLVPSGVRAPVHRRSVMTMGLNDGKKGVLLIAGSRYAARSKNHTATTNTTTSAPVKKRRKILPITPHEDIYNIPNLLTFSRLLASPVIGYLVLQEQHAAALALFVAAGLTDLADGYLARRWNLKTVVGSVIDPMADKTLMTILTVTLAMKGLLPVWLASIILGRDVGLAMSAIYFRWISLPPPKTMTRYWDFSLPSAEVHPTTISKLNTALQLGLIGACMAHPFMITMGPYWDFSLRAMQYTVATTTIWSGLSYVFSKDAVRILKQPQEPEDEAGSDDDKKKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUV1</accession>
    <name>A0A2T6ZUV1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000096">
        <property type="protein sequence ID" value="PUU79270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUV1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="18334" checksum="29D9FA961F4262D1" modified="2018-07-18" version="1">MGCVMKSRGDTYVHFNEYFGPYPGPEDDTKGNHESYTDSTDAGMPTPALAGREQEFVACGLKLNGSAAVTLGRVVKEEFGNPILDLNSTVSAYLYQIRVPPKPRVKHCTLDQVNENGSSMSNSYASRPQIRRPARKRKVEFNIDSDSNDYGHDVVKGRHKHSDCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW78</accession>
    <name>A0A2T6ZW78_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1080911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW78"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW78"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="56"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="399" mass="44738" checksum="9873EF1EA7181F87" modified="2018-07-18" version="1">MRSLLRSLVSSGGHTHYRGRLHSLSSGPFPICCRQTSPVHYRSVSTESPTREPLSILFFGSDHFSATSLKALHDEHLSNRDLIRSIDVLTLEDRRSGRGMKTIREVPVKSLAKSLSLPRHEVYNFESDWNLPDNIFGEKINMLIAVSFGLFIPARLIEDAKYGGLNVHPSLLPMYRGAAPIYHTLLDQQPITGVSVQTLHPTKFDRGDILLQTDPPIKVPPKTRYQALHDTLAIHGAELLVETLRRGLFVPPLNPIKSNYKPSLAPKIDPEIHARIDWRSQDAEELERRWGVLNTLWCKLSSVEDPEIERRKRAILSGVGVFKRPEEGAEEIETQPGTFQHLTVRNGEDSYETMIIKCKKGGGWISVGGVKIEGKRLVDAGEWARSILAQKGKGSKIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWF1</accession>
    <name>A0A2T6ZWF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1080790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000081">
        <property type="protein sequence ID" value="PUU79819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWF1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="8931" checksum="DE0680AC3B160AF8" modified="2018-07-18" version="1">MVNWFPLTAPPPYSPSSAAIKEPTNPNVPQIPKVYPYHGFGLGKGTSPLGGLPYSLPYPAIKPPIWSSHFCSDSDLIVYCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWW6</accession>
    <name>A0A2T6ZWW6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear assembly factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1100544</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWW6"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000002">
        <property type="entry name" value="H/ACA ribonucleoprotein complex non-core subunit NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="313"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU79950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="610" mass="66889" checksum="B2264BA7983EF90F" modified="2018-07-18" version="1">MPDQQAPPEGQPTVSPPTNQPDPCSPRSWGPQENIKQEEVPEPVGPETDIITESTEDDGSGGPQEKIKQEEVSSELDINFPPPADATSQTKAPTQEEKKSIDLDFLGAAQENRGNPDSEWQFSSDDEVSNEEASSADEEDSDEEGRYSPMDSAEMAQLLMREDSGYDNSPSVCAPHRTKNEIPEDEAEPDRPTISLTPEMPIKPVGFVKSIVGKLILIEASDAGHQRVLGEGSVLALEDRTILGVINEVLGRVEMPLYTVRFKSPEEIKELGVTVELKVFSVVQHSEFVFTQPLKAMKGSDASNFYDEEIPITEQEFSDDEAEAEHKRSLKEARQDKRGDRGGGRSDNGGSSARNSSTRGGYGGGRGWGSREPIPTHIDEPYIPLARPANLQEMYTSAPPPPPGPRGEQRGSNRKRGDKGWGRGSHRGKDSFTGRGGRRGSHSQNDSDRPQLPPSVPTFSSNIQSSQPSPSFQQPYPYTFPPQWPAPEQQAEFIRLMQGQTGQWPTTRQFPISPFSLPLHPQYQQLQQQGPHFAGQSNPQQPQLHNLPTGAYINPAFWGGQGQAPQAQAPQAQTNYSPPAPTQQVPAPADETATTRTVRESLEILKNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXA3</accession>
    <name>A0A2T6ZXA3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable electron transfer flavoprotein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1080305</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 10">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXA3"/>
    <dbReference type="OrthoDB" id="1715808at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000041">
        <property type="entry name" value="Electron transfer flavoprotein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000001">
        <property type="entry name" value="Electron transfer flavoprotein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="11">
        <location>
            <begin position="38"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="280"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="297"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000089-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU80096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="353" mass="37222" checksum="272A853345FB1C99" modified="2018-07-18" version="1">MSVCLAQARASLFRPFRQSTRSTISSRLFLLSPRLLSTLAVLEHKEGKVSPQSFPAVTAASKFGGPITVFLAGSGSEKAAEQAAKLNGVEKVIYTSNNAYDKGLPENFAPLLVENIKKGNFTHVVGAHSAFGKNILPRASALLDVQQISDCIEIKDENTFVRPIYAGNAIATVRSTDTIKIVTIRGTAFLPAEETSNTAAIEEAPVDPNAECTTVWISENLTRSERPDLGTAPKVVSGGRGLKDKENFDKLMPPLADALGAAIGASRAAVDAGFADNSLQVGQTGKVVAPQLYLAAGISGAIQHLAGMKDSKVIAAINKDPDAPIFQVADVGLVADLFQAVPELTEKLNAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXD6</accession>
    <name>A0A2T6ZXD6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">valine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1080138</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXD6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXD6"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="74"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="773"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU80153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1011" mass="116991" checksum="310373D60B01D342" modified="2018-07-18" version="1">MRSKPCSLDKIPITSRHLLTCTRPFLSKRTLETSTSKTTSATEETKANDDGPVPKPRNELFRKNFVPSEIEAGWYDYWVSRGFFEPRKNRPKKEIHMLLPPPNVTGQLHIGHALMLSIQDALARWYRMKGYNVFWRPGTDHAGIATQSVVERMLEARKGLTKEELGREQFLKEANRWREENGSAILRQMERLGTSTAKSLEYYTLDEDLSRVVTRAFVRLYDDGLIYRDTRMVNWNPQLQTAISDIEVVWKEIEEKTMIEKAEFGVLHSFAYALEDGSEIVVSTTRPETIPADRAIAVHPDDERYKHLHYKYAYHPLLPDVKLPIVPDAELVDPRFGTGAVKITPCHDPKDFAFWKRHTSQGTEKKIDIPLVALFTETGRIKPEAGIQSLIGQDRLEARRLVVTLLEDRNVYRGAKEHPMRIATCQRSGCVIEPMIQPQWYLKMESLAKATLEATKNRLPRIRPDVPYQELWVRWLRETQDWCLSRQIWWGHRVPAYRVVHPFGKTSGRWIVAASENEARAKMTAEERSVCNLEQDSDVLDTWFSSGLLPLSTAGWKGGDSDEVPLRYPLSFIESGSDILFFWLARMAMLCHYFMGELPFKEILLHPLVCDANGKKMSKSVGNVLDPLAVIEGRTWEEVTNTVKREHKHEVRQWRRVPERFQLIEKEIKRKLQEAKSLYERTGIRESGADALRMALINFTKQSREIKMDLRQVNAFRQLNIKLWNAAKHLHLAKANAERVTMTPIPILPIDRVIPRKDFTQLTNKTLNMHDWFMIDRLRGVIEACEIAFEDRSLYKATESIKSFIYDDFCDVFLEFQRTDMAPESDPNKRQLAMSLTTHALDILVRLMHPFAPFLTERIWQCLDPERQAANANTIMQEQYPKLEDIPRIEAVLVTPMHYVLDLVSRLRSLAGTARERQEAIVYITPRQPVLAGYLKEKMRILQIITKVNVDVTTNKDDIGSTQEAPAQPRAEEESVWQAYEETLGDGGVRTVFKYQDVRERWLKPQGESED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXG1</accession>
    <name>A0A2T6ZXG1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1192095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXG1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXG1"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140278">
        <property type="term" value="P:mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11889">
        <property type="entry name" value="SH3_Cyk3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000168">
        <property type="entry name" value="SH3 domain protein (Cyk3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035553">
        <property type="entry name" value="Cyk3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122121" checksum="71199EBA0D4A042E" modified="2018-07-18" version="1">MPGEGPPLPNRFPCLCKAIYSWGGETKRDLGFVEGDLIECLNAGDGQWWMGRLRRNKQIGLFPSNFVEVLDDPIPPSRPVSRNGVSSPTPHGGSISRAASPAPSMYSRAASPQPPIHQYLDRGRSPSPNPYQHQQSYSRAASPNPYPRATSPNPYRAVSPDPYQRHSRAPSPNTYQRAASPNPYRAVSPAPGSYNSRAPPANYQRAASPSPYIGHSHVQDDFPPPAPPPHRYQRASSPSPPQDGRRTPAVDRAHSPGLLGNTPSPLRNAMEDVMESLEHMASHDERPRTPHHDPWSPEAFADQFHPSPKRRSYIRPETSLGIGDRNGYPDEDDENEGMAYPDKPRRPASRVEDRTRRFQSSDRYGTDDDDVPPAPPPKNPSYSETTRPRTGDASIQNRKYMYDVGSKSPSPSKLVRPRPLSRNTTIKSTTTSNQSSSTNTTTSTAATSESIMSGISAGGFSATSAGSLARRKLKAMSVIEGHGQRFSLSNFGRTETPSPSPGIRPANGGAPNVLRRGQTWAASEAVPSGGAGVFGGLTAPKPKKTGFLKKILNSAKTSTASARSVANSPTPFSIPKTIPDGISSIAGGKAVAQQQGQDWVQVRRDVNRSNTFSRNERIERQERQQLMDQVVLRPVDALDDDVDGDEAADGGIVQRPADFDAANLSLVDKSARFIGNPPPFTTPESLANHHVCRPYRSDVQRLRAIFTWVSEKIAWEHPSGPLNGEVGGELDTRTVIAQKRGSPEEVAAVVLGMCNAVGISCETIRGYLKAPGEVLDVDMCPRPNHWWNAVIVDGEWRFMDCSLASPTHPRRVMYSSSPLGQADFFWFLTKPSQFCWTHIPIMMEQQHLVPPLPMPYLLALPCACPPFFKHGLQMINFDTSLTRIEDLEVAQVEFSVPVDIECFAEVEVRGFATDQDGDIYDTGDVVKKRALCQVAWENRIKTYRVKAVLPGDEGQGVLKIYAGKRGLIHSIKDNPHPLALALPIIHTGENPPYDFLVRHPTPHAQRHDLYVSQPQCSKLAVNNTFVFVVRQHPSDGSADSPSSASGNAPKPAKLAIQTPSGKILRLMKKPDSAGTDNGMVWETIIKCGERGSWRALVLADRSARWCVYAEWNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXT7</accession>
    <name>A0A2T6ZXT7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1172306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXT7"/>
    <dbReference type="OrthoDB" id="5389241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="23857" checksum="F5A840AEA173982D" modified="2018-07-18" version="1">MPYQFSSLNLNLTFSPGEFPCPNRQCPTKFYVEIPLLVQNTRTRTTLPATISQPTRDLLVGQCYACQERICLLCLNTKHVSSQCEVTPCSVALDKFREAWGAFEKACPTSIRARHEGSIEERVMGDLDVWDAMMLVHQVRLREARFKELEEEGDGGSFVSVGDSEMSWEEETEETEEEKEARVWEGLRRELRDAYEVLMEGCKCSDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXV2</accession>
    <name>A0A2T6ZXV2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXV2"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="33012" checksum="C86C53DF6FEAD1EB" modified="2018-07-18" version="1">MERSEESSSARVCLFDFVAVVPLTNSALPGSPHQHNHSASVQFPTSLHISYICSVTLITLASAAVIPDVGIDRRQDNAAISWRDCTWEKAFLEADFEEMRMLAKKAAENVDSNNAISTAFFGKEPSVTWIGDARIKKRYTAMSNFKSKPLRDTTIRCNTNIPACKSKHLPVLSQQTKGAQTSTSATHTGTPGHGVQSPGKCPHPETPRSTVHWMSTYPLDHNYCMNSPMRDSLIIINPATQRTEKAYSHRNTLLLARDSPQKAREKADNYKLFAIASYFDRNHWSVNPDRLSGDSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY38</accession>
    <name>A0A2T6ZY38_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY38"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="131" mass="14137" checksum="DA3BDD62DB583BE7" modified="2018-07-18" version="1">MPIFHDTTGSSDKDSGRIRHAIMECFLQVVLRHHPDTGGVRDAIAKPLYNSVLPHPIYQPPKGRYHTSTFHGATESSEGRIPGALGQPSRSSITTASYTIQAVHHQQGVSIQELSIALQSLLKGGDGAVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY50</accession>
    <name>A0A2T6ZY50_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY50"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY50"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="33256" checksum="F5905BC99086174C" modified="2018-07-18" version="1">MALNRSLIRNVWFHETRSQEKTLRGPFQNGSITEGNFLDILGIVLVVQGNPLQVQERESGHILSQTDIPLNKGVYDIYCDVSIKINNKPWIPRSITHYTGSRADRFCHQLRNRDRKCVISGLINPKVQIKANNWLGFEPAHIFPPEQEGLWTLDDYGRSITDINDSFEIAKIDSCQNCFLLSSDIRQGFEQYLISVNPDDNYKIIVFDIDMLGLEDRILDPLCRNPEGPHREGEPIFEHDFPPGHDIVEQILAVLYGQERFELEIASRLRELHKDKNLSHGEALQLQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYD2</accession>
    <name>A0A2T6ZYD2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000063">
        <property type="protein sequence ID" value="PUU80497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYD2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18391" checksum="08C16D9381888E3A" modified="2018-07-18" version="1">MREEEESGARGHSTQRRAISLEIEEVVGSNPPAPCSQESTSTPSAPYTQAQHRDVQKVLREMPWLLDYMIDNGLAAALRSGFDGAQDASPSCLPVICDEHPVSPTVAPIDAHVQTTPERGTEHADPMTELAAPMTYLAPRPSTTPGAGSAPSNTQSPSPQLRRSKRRGAGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYJ0</accession>
    <name>A0A2T6ZYJ0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1100220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYJ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYJ0"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="24383" checksum="F85B4126A72B2465" modified="2018-07-18" version="1">MDVCVASGYRYAPPEFPPQDDGMERPPVFSLDVLADRSLVKDVVKAVISTIFFHRFFPTVRPKTRDLLDLTLPAVDDAELDELINQRTNVLIRSMEVSAGVGTKPQHGQVAVYTVEFYERRPKKNWFSKAEEKVCWEQWVLSVTVVSARTDAERIKLRMSIEAQLQAAVLDIISTVSMKKDHIPPITTNEANPFPYSIIVSPKGETWGARMGIFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZA6</accession>
    <name>A0A2T6ZZA6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZA6"/>
    <dbReference type="OrthoDB" id="5400463at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="385" mass="42696" checksum="0C091BCF74909040" modified="2018-07-18" version="1">MCPSDGYEEITFRFLAPQIADAIYECINETIVCLTCAILCHTLRAWRTGALLDPPEFKSEAVRGKSFLISGPFVPFVQDVESSQIRKIFSYGRGTHGGGSQGQRKSLMLRNLRETIMDKVNQENRVLKERREGFADNHEAVHAELERQLSSRNPRRPAAREPTPINTGARGLVGRLESQLERELSSQEPRRAAAREPTPINTDGRVLEGHQESQDASQESAKSFDFSQSAFARALRGLNAESVTFDDSLDLTLEQEQESAANPDLASRLSLNLDDFQEDQAAVGENVRQNGDESSHLHHAPPNATGALERPAKHARRRTLQSTTYADIETEHDAQATTETVRLSDESSDEDQNSRGSDQTELDTEPDAEDNDIPEATGAGLHHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZD4</accession>
    <name>A0A2T6ZZD4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_973428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZD4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZD4"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31726" checksum="EBDFA036173E859A" modified="2018-07-18" version="1">MEQSNNSNRIGKWLKDVIINHRKGLQKMYGETKLELDQSLQRPIKRGEEMARKLVTMGCGIEVAKDLTLLTLYDVAILIDDSESMIYGESGTRKNTLIQFIDHITEIYSMANESGILAMRFMNSRRGKKNWTGKSQAYLDGHSFIGPTRIGTELKKKILDKFVIKDPNQSKPLLVLIVTDGAVEGERNSHLKNVIQDCVNELEASGKGRDAVSFQFSRIGSDPGAAMLLEDLDEDPDLAEYIDVLPSEFDLESLLADKWFVLPKILLGAILPKVKPLHLKPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZX3</accession>
    <name>A0A2T6ZZX3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1078083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZX3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZX3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15997" checksum="B7171F30650A270A" modified="2018-07-18" version="1">MHTADKFQGRDKEIIVISLVRSNGDQNVGELLRDWRRINVAFTRARSKLLILGSRSTLQSNELLADFVRLMERNKWVYDLPPDAQLTHFMPQTQFPASADFRKVGTAKGPENRINGKKSLSSRNDFLGSRPVLKDIVNGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A054</accession>
    <name>A0A2T7A054_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_652836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A054"/>
    <dbReference type="STRING" id="42251.A0A2T7A054"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015744059" evidence="1">
        <location>
            <begin position="21"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="19132" checksum="669B6D9DEE9802D8" modified="2018-07-18" version="1">MKFTLIAALSVLSTLVSGSALPDLTRRGTVIRPAIGIMIEEKFPDYDFPPINAVEVSRTNGADNVRSLLGFVVPACTGTCTFSFSDASTATGSGQINLFTLGWYPVFGNTWNSKPFTNIQLGTFQASTTGSGPATVVQNFGLTFVCPTTTTNLGYEVQPVNDNDFVLWDITNGGLILTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0E8</accession>
    <name>A0A2T7A0E8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_972495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0E8"/>
    <dbReference type="STRING" id="42251.A0A2T7A0E8"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015501670" evidence="1">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="119"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="353" mass="38071" checksum="E9F2540F018721C4" modified="2018-07-18" version="1">MKLTISPLLLLSLPLAIAAISPAPSCPAKNVTIPALDPITQAWVDAGSGNIPISQMTISEARIAYDVMAGNVSNPPSADEITTKILYLPVGPTGNVTVYLYKPGSGYREEEDKGLLPVVVYFHGGGWITGGPKSYEGLAYDLVRETGAAVFFVDYARSPEVVYPVPTEQCYSAVQWLLEHGEELGVDSTKMGFAGDSAGQTSAAVTLLSIKRRTPLPKYQVLFYPITDLSCESPTYKEYAQGPGLTVDAIRYSISLFAPDVKSRFEDIASPARASDEDLAKFPETLIIVAEVDPLVHDGEEFGRRLQKLGVRAATIRVLGIIHGFANINPLNETPEGKAAIELMGLKLKKALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0H0</accession>
    <name>A0A2T7A0H0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0H0"/>
    <dbReference type="OrthoDB" id="5375356at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="286" mass="32024" checksum="DDA5EC2D855D9EC3" modified="2018-07-18" version="1">MPAISITSATIHGPESLINPLLKWYRTCQSAYDAAPENDRVWELINAHTKDGLNILQAEELISHLRFRRAESCRIEHLMSEMGYPPRKPFEEFTRRDVVTIKQSFRDVIHLHTHCVYSPLIGRSDGGVVGGPPIGHIGVPVYWAVVDYAAWIAADWKADPTVFAQRLENQYQELVRYWSHDKEGLEAGAHPQTLGRFEGTGEYSSGWAAAQVAAFETIFPETWTEALPMAWYFGNVTDEYGSPEPLELGSGDEYDGEEPKEDSDDGDASEDVDQLGYSCDEGDSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A150</accession>
    <name>A0A2T7A150_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A150"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="21083" checksum="7DC8BA0B83724651" modified="2018-07-18" version="1">MFHGTSLSKLESINSSAGRQRDKAEGATFDDLKTIGDGNQVGYGGDAIADTCLYLGTEGRRDYGIYEKLYGFPPQIVRDITHAETISVLKTHVDVIEFTPSPRVAHGEVQAPAPQAEDKKFKELFDDFVRLLKESDYDCGYLQGTPTPLTQAYGAFTEYNYERKKELEKVRERERGGRGEGWYIDGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A156</accession>
    <name>A0A2T7A156_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Squalene/phytoene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1099695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A156"/>
    <dbReference type="STRING" id="42251.A0A2T7A156"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="346" mass="38730" checksum="F8866A50F481CF80" modified="2018-07-18" version="1">MALPRIHTRSLPLLQSCAQFPFKPPISPYSPTKRHSSTLNVASARAYCLDLLRKHDKPSHLLSVFQPSYSKDTYLSLRAFNTETSLIPDQVSNTTLGRLRINFWRDNLTKLFSPPPPAHHYTPPAEPTLLLLSHAVHANHAKLTKGFLTRVLAEREKYLGNVPFRNMQDLEAYAEGTYASLLYATLEGLGLRDTGLDHVASHVGKAEGIVAVIRGLAVLARVEEGGAVVLPLDLCAEVGLRQEDVLRRAQGRGSGDDGEDAVGRLKEVVFRIATLANDHLITARKMVAEEPTARGVAFSGFMRAVPTAIYLERLERVDFDPFDNRLQRPDWKLPWRAYRAYTTRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1B5</accession>
    <name>A0A2T7A1B5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1191000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1B5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1B5"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="279"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU81530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="467" mass="51871" checksum="4154ABE852D50637" modified="2018-07-18" version="1">MEDSNEYERLRQENILKNKELLLQLQLDAASVGATKKAAKSSSGSASKPKNRSVKKEPQSPLPRRKSSRLAGLPADSEVAKRKYDEGVAALQEAERAKRARVAGDLSFEIKQGLVDIAKGDRFERTFTDENVQETTDKDLRAMRQKMMGLRLYDQHLPNDIKICPERILGTLGIFDAQSNKEDEDGNPIADISQYKVHSRSISAITFDPVSARSLYTSSYDGSIRKFDLATGVASEVFVAEDGDAFSGVEVHDVNMLYFSTLDGLFGRRDLRQKKTDIWTLHEKKIGGFSMHPRAPHLIATGSLDRTLKIWDLRKVVKTPEYRTLALVAEHPSRLSVSCALWSSSGSLATTSYDNTIKIYKFPDAVKWGPSSNFGIAQPDVTINHNNQTGRWVTILRAQWQQAPPNGQQKLVIANMNRFLDVYSEDGEQLAQLSDENVTAVPAAAQFHPTQDWIAGGTASGKAILFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1L0</accession>
    <name>A0A2T7A1L0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chaperonin Cpn60/TCP-1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1076572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1L0"/>
    <dbReference type="STRING" id="42251.A0A2T7A1L0"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="547" mass="59088" checksum="6200DD6631F07B69" modified="2018-07-18" version="1">MSLQIPSAPGSGLFKQGYQSYASEDGAVIRNIDACQAIASTVQTSLGPYGRNKIVINHLQKMILTSDAATILRELEVVHPAAKLVVMASQQQEAEMGDATNLVIVLAGELMKMAEGLIRIGLHPSEIVNGYEKAQDFALKTLEELVIDKIADIKSEAELTKAIRTVIASKQYGNEDLLAPLVAQAVLAVLPKNPINFNVDNIRVVKIMGSSLPESRVVKGMVFPREPEGTIKKALKAKVAIFSCPIDISQTETKGTVLLHNAKEMLDFTKGEESQLETIIKEIHDSGIRVVVAGSAVGELAMHYLSRYSILVIKILSKFELRRLCRVVGATPLARLGAPMPDEMGTVDVVETEEIGGDRVTVFRQENETTRTATIVIRGATQNHLDDVERAVDDGVNAVKAISRDPRLVPGAGATEMQLIERIVAHGEKTPGLLQHAIRKYGEAFEVIPRTLAESAGLDATEVLSKLYAAHHKRDSWTAGVDLEDEKGTGILDAKEHGILDLFVAKGSAIKLATEAARTVLAVDQIIVARQAGGPKPPGPNPNWDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1W2</accession>
    <name>A0A2T7A1W2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase II subunit beta</fullName>
            <shortName evidence="4">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1121856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer composed of two alpha chains, one beta chain and one beta' chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1W2"/>
    <dbReference type="STRING" id="42251.A0A2T7A1W2"/>
    <dbReference type="OrthoDB" id="2275560at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="652" mass="70643" checksum="DC7BD79040A2CE9D" modified="2018-07-18" version="1">MPPTPPPTSTDNNREQLDVNYPEARHYQLLPDSPDSPPTPPRLSEARKQQLHQQSQSNLLGDPTNLHSSPDDKQGLVRERAGSVRVKGSEVPLSSVIGEAFATEDLIHSDSDLLVPEDGDGHSRTHTRAAPAPPAVATASTSATTTTASAATTTTTVTVYACPPIIPDPVEKDDGEGDDDFYDLTALRGAGLYRRSGARDQLGKGQVSAGLVRRGIGIVKRDEVGDFARRDGDINSSTTLGSGRLQNAELAGRYAQTRSHPQHPTSTTFQNSPVHSHSSDQSVSEEEENSEVEEEEEEDDMEEEESWIGNFCSMLGHEYFAEVTEEFIEDDFNLTGLGQMVPMYKEALEMILDVEPEDDSDSQGSASESLSEQTGAQGGAYRRRSAHMRVASDLSVIESSAELLYGLIHQRFITSRQGIQMMYDKYLANHFGFCPRVYCTQARVLPCGYSDTPGVETVKLFCPSCCDIYVPPNSRFQTVDGAYFGTTFASLFLMTFPELDTSGNGRKEVLSGTSLNSAGGKKGVSQAGAPSINGVLAANLAPGLGKGKQYEMRIYGFRVSERARSGPRMGWLRSRPEDISLLDETAKSGAAAEEEVEYSSEEEALEDSEGEEESADEDEMALGWDCAAGSRPETSRRAGITPMDTNGTGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2L8</accession>
    <name>A0A2T7A2L8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1099430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2L8"/>
    <dbReference type="STRING" id="42251.A0A2T7A2L8"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="647" mass="71855" checksum="30E99FB81D1C40B2" modified="2018-07-18" version="1">MAPHSTTIDTAHIKATAQKELLDLLVAVRGKKTLILDKSLSGPVGLFCKFSALQDHGVDKIFWLEENVVADVTQKNIVFLVRCTVKNALAIAAHIKNNAKIPGQQFEYNVMFVPRRTLVCEKILEDEGVLGDLTIGEFPLHFIPLEPDLLSLELEDAFEELYLRKDYTSIFYSARALMNIQRRYGLFPRIIGKGDCARRLADALIRMRGEEDASDSNSSPFTLAPSSILGELIVVDRESDFMTPLLTQLTYEGLIDETIGIHNSKIEVDSSLVGGPQQSGVSTASSSSVSPVAASSQQKKRPIPLNSEDKLFENLRDTNFAIVGNLLNKVARRLSDDYEGRHQAKTVSEIREFVGKLGSLQQEHQSLRLHTGLAEEIMKHTRSDIFNRILEVQQNLAAGVDPSSQHDAIEELIARNAPLESVLRLLCIESLVGQGLKPKDLDNFKREILQGYGYQHVLTFTALEKLQLLQSRTSITSSTPIRTNYATLRKSLKLIVDEVNEQNPDDIAYVYSGYAPLSVRLVQCVIQKPLMVRGRRGEDPSTPAGTGTAVNWAATGWRGFEDVLKSVKGKTFDELQRGEEKAVRARNLLNGANEKKVTVVFFVGGCTFTEVAALRFVGRREEGKREIVICTTGIINGDRMMKAAMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2T0</accession>
    <name>A0A2T7A2T0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2T0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9895" checksum="8ABB7742233AD698" modified="2018-07-18" version="1">MMLRAAAPPPRLYLNLNNTRLPRTITSSLLLPVVVLPQFRTAHSSHNKNHRHSPKPAVPRRAAEPITIPPPVLLSAYQSELHPHHQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2V0</accession>
    <name>A0A2T7A2V0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA-processing protein TSR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1018421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2V0"/>
    <dbReference type="STRING" id="42251.A0A2T7A2V0"/>
    <dbReference type="OrthoDB" id="263560at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="22724" checksum="5025589ACEE8F006" modified="2018-07-18" version="1">MATVRPTHLATMGSAHQPVVAQLSSQVTAKWELGVSLILDNWDVLTEAVNNLWGGEDSSGKRDWLAGAIVEMFVGRPETDEDDIEFTLLQVMEDEFSVCLEDDSSWVVARQIIVLRKEIIDGNFSTVDKLHAKFLAKPKNPSASSMLKEVVDPACSSSSEESEDDEEMGDAPPAAPSEPRQLRKPLEPTIDEEGFELVQKRRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3J8</accession>
    <name>A0A2T7A3J8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1190535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3J8"/>
    <dbReference type="STRING" id="42251.A0A2T7A3J8"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="90"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="184"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU82298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="559" mass="61917" checksum="0F300B5D6A914E62" modified="2018-07-18" version="1">MSNTCLSCGSSNPADFDDSTGRVVCTNCGHVVNDSFIVSEISFGETSSGAARVQGSYVAEGQTHAGGGGGRFRSGNSLESREQIIQNGRRKIVSLAGAVNCPEHFADHAQRWFTLSVTHNFNRGRKTQFVVACCLYIVCRLEKSSHMLIDFSDILHVNVFSLGHTYLQLVQILEVRLPHIDPTVYVYRFAKHLDFGGEQTKVANDALRIIQRMSRDWMVQGRRPSGICGAALILAARMNNFRRSVREVVYVVKVADLTIQKRLDEFKDTKSGDLTVEEFRNIWLEQAHDPPSYGPKASKRRKRVRDVNDDGEVIEDPQDITIVAAPAEPSAAPSAPGTPPSAPASAAATPLTFDRPLRLDADGFVIPELPVPSPRPISSLPGTPIDATEDTTPQGAEKAQDDQHSAIAEEVIESEIASLLGGSAASIMEELRDADRQAREECATSPVSDDPDNLDDVDDDFEVQNALLTEEERDLKEKIWVEFNKDYLRDQELKRLKKETDLRNGIIKTARKRKKNKPRDSNSKDMAATPADSAKNMLMRRSYSKKINYKAIEGLFEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A468</accession>
    <name>A0A2T7A468_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A468"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="12203" checksum="5E7387BE2A2D00FC" modified="2018-07-18" version="1">MSTGDVSHGRGGMGNIGPDETEYIDGEIVRTGDPTSAGGAYSAGRGGAGNIGAPQRDPVRPSMDEDVVPSPAKVQAHENEGFHSGRGGEGNAHLPEGEKKNEGLAERLKRKILGWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4I8</accession>
    <name>A0A2T7A4I8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4I8"/>
    <dbReference type="STRING" id="42251.A0A2T7A4I8"/>
    <dbReference type="OrthoDB" id="5394189at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="218" mass="24843" checksum="77F059E8856EA6D7" modified="2018-07-18" version="1">MRCVDPSPDSEKAYNLKAPPANPNTATISTDDRDLSSDEDVKPIQRNYFQNSIALPELTELFSKAVVVINFSNLTGVVDLLRELLEDGNRCDRSTKDVSKWRAERSNASTAVTKFIGKYFLDMKLIRPPKRLKFAQACVLCLHPYCGNRPTFDVADAMWRMLRALELDLAMAKECGVDAVFQYWHDKNIYFKRVRKIALEVEKRLMDMRCVLVGEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A551</accession>
    <name>A0A2T7A551_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A551"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="382" mass="42543" checksum="E7354A483D9B78F1" modified="2018-07-18" version="1">MEPTVAIRDLDLRKIAVLREMTESDVHFQNVSDKELRKWISENPEVVEHKDFRYEYNFLSQRLIIKCMPTPTHDTLQYFFTQTVFGTIVEKVGLLKAQELVTTGAGTSFTGFEGDLCGSTEKLPDAFVQLEGSDFPVVVCEAGWAEKLDDLKTDAKLWLLNTGGQTKMVIVTSFTETYTKSETNPTSETNPTSETNPTSETDPTSETDPSSEVSKGATGTGGGQVGKRAGERALIKSINESTKLRDLANQLLDLNKHEELGKPLIRKLQASLYVYCANEDHKDITKVFSTELLPPPPANSKAPPLFQITMKEIFGKDVPEGMKSTDPITFSLPVLRKIIEKSLPGTAKYRATRRAKKLLQEKGVLGECETFAQRKRRRMDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5F4</accession>
    <name>A0A2T7A5F4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_254699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5F4"/>
    <dbReference type="STRING" id="42251.A0A2T7A5F4"/>
    <dbReference type="OrthoDB" id="10670297at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015781185" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="953" mass="98860" checksum="9F8A41EC23914D94" modified="2018-07-18" version="1">MRSTLQFFIILTIIWGGLAQTKLDLSKLPECCSGCVSCLEGTVKCSGGKASNVVLDYNCLQGCPDGESATAETWLSSLCGPQRPYYPNTTQPIHEKPTPTPSYSTSSNPPPKYSPSSITTTSPQESKYKTTTESSYIPEKSKTVTEKEPGTTLQPPEKSQTVTEKEPGTTLQLPGKNQTVTEKPPGTTVQLPGKSQTVTEKEPGATIQPPEKYYTDTTTKQVQVPVTVEGKNKTIANPTTIYSIQPPVTIEGKNKTVANPTTIYSIQPPVTIEGKNKTIANPTTIYSIQPPVTIEGKNKTVANPTTIYPIQPPVTIEGKNKTIANPTTICAAQPLAKTVIGEADTVTVTVVKTVVNVVTESVTIVDKLYATDVKTETAIATVVKSAIATATATVTIRESFDHTATEVGTVTVAKSGTVTIKESFFNTATELGTVTVVKSGFATVTIKESFVNTATEVETVTVAKSGTVTIKESFFNTATEVGTVTVVRSGTATTKESFFNTATELGTVTVVKSGTATVTIKESFTETATETATAVATTAVTLRETIVVNESFTATIPAPTTLRETVTVTNTPPVQVQTQIQMATTAVTLRETIVVNESFTATIPAPTTLRETVTVTNTPPVQVQTQIQTQLLTRLSTQVQTQTITSVSILIPAPVIITATSTVYNTAFPPPSMVTVTNPAETRTITFPAQTVSATQTETTTATETTTATETTTTTETTTTTAKETVFNTQILPAQFITVPSPTTQTVTATSTTTTTITSTTTSISTSIIVSPSVPCPLMTTTSTTTSTETTTTTTTTTTTTTTTTTSTITTTTTTPTTITSTREITSIAAAVTITAPAPAAPTRSGIILGSQGQLDRIKDRGLWLEPLKIIFPCMAGWCIMVTLLWKLCLVGSAIAIGGAAGGAAAGGAAAGGYAAGGAAAGGAAAVEAGGAGGAGGLGGTGGLGAGAGRVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Z4</accession>
    <name>A0A2T7A5Z4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1061242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Z4"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Z4"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="37734" checksum="FAC8C2A741766DDC" modified="2018-07-18" version="1">MPPRAFHQTSTSNLSTPEGTYIYTLTSLSATHLAASTSASSSSSSSLITFSKSTLAPTTTIPHAHINITSLNAYPASPQTLLTSGTDGLVKLWDLRCSPPAALASEINVGAPVLCASANAQGGIIAGTEMRDHVSRVCVWDGRVVGEKPTWVFTESHGDDVSFVGFAGGEEGRRWGVSGGMDGLVNVFDLLAGKGAGGEDDEKALWQVVNVGASVHRAGFLNAGSGGTAAAGKGEWAFGISTDESLVLRSFNHTPGGGGEQEDAEGEVAGNVGDVRGRLDCEYVVDVLRASSTGAGGIVVAGNKEVGKQRIDLVPLRWTGGGGQWGFASEDKVRLQGGHGEEVCRGVWVDEEVGLLSFFLSCPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A635</accession>
    <name>A0A2T7A635_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adaptor complexes medium subunit family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1119598</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A635"/>
    <dbReference type="STRING" id="42251.A0A2T7A635"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="188"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="528" mass="57245" checksum="8944DDBCB499BC7E" modified="2018-07-18" version="1">MSAVEALYVFDNFSPATTPILQHEWRSRPATTAASLYSLYKAQPSPRPSLIYLPTTSPPTLLFNIIHNNLLLLSPTTSEIEPLLISEFLHRVIDVLEDYLGSPLLGSKIEANYDIVAQLLNEMCDDGFPFTTEPNALRDVVLPPSLMGKLLGSVTGLPSASIPSSFTPTPTKTLSAIPWRRSNVRHTNNELYVDLIELITATIAPSGRFLSARSNGTIAFNCKLSGIPDLLMTLQTPTSHKQKLGAPPSGGLGFPVFHPCVRLSRWRERPGELSFVPPDGKFVLASYEIDLLPSGNPKSATQPQLPVSVELKTAIGPQWSEFEARVFISTAFLATTANTLSASPFGPRSSRSPAFGGSSNNPTVEEVRITFPLPPAVKTLTGTRCSRGEFHHEGRKVTWKIPTTSAFSGTATFRTGVVIKSYGGDDNEVEEEEPVDNGEYQDVQTTKTAKANGGNEGEKAKREKQAKRKMEMAMPRCALVAFSVKGWLASGVKVDSLKVVGGKGLGEGVKPYKGVKYLTKAGDIEVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A660</accession>
    <name>A0A2T7A660_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A660"/>
    <dbReference type="STRING" id="42251.A0A2T7A660"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24504" checksum="921CA30CCEA75890" modified="2018-07-18" version="1">MIEDFQRGEVDTYVRHIEAGVEALSRDAESLLVFSGGETKSAAGPLSEAESYYRLAHTLHLLTPALLPRTTTEIHARDSYQNLVFSIARFHELTNTYPSSITLISHAFKEPRFLHSHLRAISYPEVNFEFIGIDPEEGVGDVVLNGEARTRQVWNEDLYGCKSEGELRRKRQGRNPGRRWDGGYSVSCPELRELLTYCPSDGVSEFERELPWSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6H4</accession>
    <name>A0A2T7A6H4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6H4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="9671" checksum="744D34D0796295B1" modified="2018-07-18" version="1">MILDLKSRRGDASLILARSENDQIVGILYHHGRNSGGQSIFGTRSPDPSIIHIHPLKEFQPPSQGEEGNIELSRTWTAERHIKGSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6K9</accession>
    <name>A0A2T7A6K9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1072749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6K9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="90" mass="9500" checksum="17679A24A9CD9ACE" modified="2018-07-18" version="1">MKLVPIGILAPITLSSTNTVLCLATIAVNVVNAFLLPSPPCSPAGSARRCYRAYRTPVVPTNVLLYHTSTRARNGECAVVAVHAVNVRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Q9</accession>
    <name>A0A2T7A6Q9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1189649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Q9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17018" checksum="A0A9FB4E00B2D1A4" modified="2018-07-18" version="1">MSMSNALKAPHLSVFSSHYPHKAPNTTQPRLLPYPPPYYHSPKHPFTIFSQASTTSTPPTPNKKFPHPQRNHYTPPHGSNPPYIKSRKLSPFSPPPLLLPLHSNAPQPPPFLSDIPPTLHVVNGMNNNISVNIPAGEEYAAQALEVVGSAQIQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6R6</accession>
    <name>A0A2T7A6R6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1142669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6R6"/>
    <dbReference type="STRING" id="42251.A0A2T7A6R6"/>
    <dbReference type="OrthoDB" id="8955194at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="45084" checksum="008CF8D812C83F9F" modified="2018-07-18" version="1">MVVMKALMYGMELYWDGDKDMARKLEIWRNRCLRKVLGAVRSTPVDAMLGELGWKSMSLELDKKVENWGARLVRRGFGERFGEGWKAEAMENGVWICGWEGRILRGLKKHFLNGERYEVQAERSGNIEWKVVIKKDKEEARLRWERKGRKEVKDGVDNKGVLQRLRKGRGWCGECEQRVRGWGKELVEKGWEVEWFWLPGHIGIRENEEVDRIAKDGYFMEEEEEIGKLLTWGRWKQRRKENERRVWKEYWRKDRKGRAYFGNEGGRKCGHGGKRVDSIFLFWMRVGHGKMRGTRYGNRERKCECEGWEDKDHVLLYCLEWVEERKDLEEVWLERGSSEGWVDMEDLLFSEEGTEGVKEFGNRTEWMKRRWKERIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Y8</accession>
    <name>A0A2T7A6Y8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1105143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Y8"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Y8"/>
    <dbReference type="OrthoDB" id="5429068at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015730149" evidence="2">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="380" mass="38530" checksum="3BB9A93064829C73" modified="2018-07-18" version="1">MHFSTTLFGFLALRAAFPEGVSASYSHQRFHRRYTQADGVVPTEVTPARVETAVVEPAHVEPATVEGPPNNAVVDVSTPPNNALVIPTSTATGVTGNPTLVPTTLATVVKVSEGSTLLTSLLAPLPTSEAYVVPTTGGTPGFSSSDSVAPTTTSTAGETVSSTPLAIITSSVITSTEGGPISNSSSTSSCISTAIDTPSTSPSTGVNATTTLFSTLASSATTSPISSNSPTNNTTITGPSSSRNFVTANSTLTPTTSLSSSTKTTFKYSTPAAPTPTTTYRLTFATPSTSAVASQSNGLSMAEFNKTKPCFDKKCDDPGSEMTYNKTVTFHVDQGGDGGVRLGRGPDVANVATGRRDNGGLRMGMAAAVVVGVSAALAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A820</accession>
    <name>A0A2T7A820_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1038259</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A820"/>
    <dbReference type="STRING" id="42251.A0A2T7A820"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="29"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU83887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="454" mass="51026" checksum="030358BF8A3B476D" modified="2018-07-18" version="1">MTSGAPPKPKPKLTGRDFYNSLGSPKTIVAPMVEQSELAWRLLSRRHSPSSTLCYTPMLHSRLFATAPAYRSQSFYPPLDGSESDRPLFVQFCSNTPEDLFSAARHVAPHCDGVDLNLGCPQGIARKGKYGAFLQEDWGLIRSLVSKLHKDLEVPVTAKIRILETRERSLEYARMVIDAGAQVLTVHGRTRDQKGHNTGMADWGVIRYIRDNLPKEVVLFANGNILWHEDVQRCLDATGADGVMSAEGNLYNPAIFQADKDWEKRFPRMDIVGREYLDIVRKEVLPGLGEKGQKLLLQDSSITAIKPHLFKLWHALLPKHTDVRAMLAKSSARTSESGDVLEAYEACLMEVEKIIKNELSQNPEPVDENGRWVGPDTPFEEGVEGIMVEIDGVKFNRLVPWYRCQPYYRPLPEEAIKKGALKVRKGAHNQEICERKKQKLDTAAGTQLATEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8N4</accession>
    <name>A0A2T7A8N4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_564528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8N4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="139" mass="16415" checksum="0F3B71D13163CFC0" modified="2018-07-18" version="1">MPTIDDNERRSGTRIFLLRFSPIVGDEALVLMFTCEMALVRLGFFFFFFCLFCFFVSKRLLGTLVLTHLPVVVTHFFLSQAWQSVLSFFAFCFCVYHSPYYILITLAFFLLYNTFYYYSMLAVILSLFMLFGLRVRLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Y3</accession>
    <name>A0A2T7A8Y3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1118277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Y3"/>
    <dbReference type="STRING" id="42251.A0A2T7A8Y3"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015532623" description="NACHT domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="70"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="673"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="858"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="782"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU84175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="894" mass="98896" checksum="CB15207E9E496A09" modified="2018-07-18" version="1">MATMYRIKLLLYMDLATFEELVACTGWGVSSPEIDIDHLCDEYNLPQSDTGTWIFREVRYREWQKSEESRLLWLCGGPGTGKTMLAKRVAAEFLKGHDDPPAGVKLVFHFILPELPTTRNSTDGDGLSQHSLANVASSLLYSILQQDGNLFDGCKAELGKQGDRFFTNPSSLWKVLRKAIRDCREGPVYILLDGIDGLKESLCKELIRRILELMKIRTVKIFLSCRGVPHISNNLPGGLRKCTKIDLDTNSFVKEDVERFIRCGVNEWGWDVDLGERAMEALLAKSEGIFLWASLAIENLTMFSSGPDFDKFLSKTPSGLQEIYRTMLHTLLSREEAGEVLNMIWSVALALRPLTFGELGHILACIEARAEQHPSDWGTISEIRPRTENEIRIYVQSSLGFLRGTAETVSIVHYTAREYLFDEHSKGNLPVLSKCLADLAVSWECFRYLHHAFGDPGRIKRGDMRGPPRWSNDLSSERDHQEEGQREIPWEVARRNPQKAVAKWPWLKYAAESWFIHARRSTDILMDQFYDDSARNWLQHQFFETSDAIRKPWIELCGDPGMEVLAGERTPLHIAVCLGIGPLVDMALSDSTEGTNSNQSPLHLAAMLMSGTYQILVAKGKQSLLTCADQDGNTPLHAAAISGHWSMLESLVKRFAAPEHRGCTGEINKKNRHGNTPLHLTFQFDHPSMVEFLVKNGADTTIKNNAQITAPDLGASLGRRDCLDILEKVRNTLGEAKRGTVDGPAVESVEEPMKEPRWGLLGGWARGLARRFSSSPNLSVHPTPASVSDSPSTPTSASAPAPQSIPIPRRNPAPRSVSIPPSALILASIPPPWSVSTSPFVSGSPGISASAPIPWSTSTPPWSFSTPSSIPSPPSTSISPSFSRSPSAWSSAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A996</accession>
    <name>A0A2T7A996_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sds3-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1098112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A996"/>
    <dbReference type="STRING" id="42251.A0A2T7A996"/>
    <dbReference type="OrthoDB" id="20886at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21964">
        <property type="entry name" value="BREAST CANCER METASTASIS-SUPPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08598">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="476"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="564"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="605" mass="66704" checksum="05038B321DBF781D" modified="2018-07-18" version="1">MPVRKEMGDQDEDQVTGPGESTPATPITTSSPSKKRKRETNGSPALRPMEEPKSRQSTPPFKKKIQIHQEMSENESTSANSRRGSNTEAAADTVSNGTVQDSVTANSKDVRASKPAKVVPPKNEVVPGNAGDEQDPEPVAETEVDEVADATASATLDEEPCDNVDTTREDDEDAERVKRKNAAMEDLAEIERVFAQLKDRIYSEKLKRVDMEMKMVQDGTHPEFVAQKTCIDQKLEEKVRLADAHYKYGMESLSIATRVSRAQVHSQYFQTVRGLREDALERCSELWYQIQRERRAGDALVSEFSYRIPDRQSTRIKQRQQYNWEVALLSGIAKHIGFPAAPDVVGASEEEIVDDLESMGIATRVPARASVTVPPPGSLRERVLDDFYERPLPINWSHMQPSPPSPAPQPTQQAPGYPHVHIHHHHHHNRRHTGPNQLDQAPYLARRGPSAQGHNPGHQPSAVSLSSLLQRDVIKMEGPSTHPPSTSSMGATPHPPPRTSQLYSSQGTQHSLPPPTSLQQHMSLYARPSNADSQQGPPPAPQRLDIGRGSTPGDVRIYNTMGGRESEAPDGGLRRLKEENDGAIGVGPPTLGAPAPLRYPRMSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9B8</accession>
    <name>A0A2T7A9B8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_960805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9B8"/>
    <dbReference type="STRING" id="42251.A0A2T7A9B8"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="301"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="455" mass="52471" checksum="367EFD404090B482" modified="2018-07-18" version="1">MNQSVIRLTRELNEIRKSNDLSIAVACRESDVRNVKAAILGPPDTPYEFGFFEFALKFSRDYPTKAPTVTALTTNSGRCRFNPNIYAVGKVCLYVTLSTLTTWRGDRGEEWSSAQGLESILISIQSLMSSNPYENEPGFENANQPHDKDNQKAYVLKIRHETLRVSIISRLEDYLGINPDGTVQPPPVIPEQDIYDDDSSMIDSEASAVFEPFKDLCKRRFLWYYDTYLASIKVESGKVTDGAQFTKMPFEHAGNSMDGKFLYSELERRIKFVKERLDHETASWAAEGLILQDKESGVAANLQRQFEQTVEHYKKQDSVTIDIELVDDNPFLWRVAYFGRPMTNLDGGLFTIHLAFSPRFPEEQPRAKFVFPLYHHQITTDGIPCYIPQRYDEGRHHIDAIVQLMEEESPPYDPRTQVNQEASKLYWGSKEDKREYNKKLRRYVSSKNRGLKQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9K7</accession>
    <name>A0A2T6Z9K7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FACT complex subunit SPT16 N-terminal lobe domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000684">
        <property type="protein sequence ID" value="PUU72182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9K7"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9K7"/>
    <dbReference type="OrthoDB" id="5471094at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="1">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="15038" checksum="F3708510DCFC4808" modified="2018-07-18" version="1">MGGGFAKHLETLKGGKFPIEILVRGKDGAQNTQNFKDLAEKKVGACVKDKAEGPFINEWKKIFPAEIEGVEEFDVSSAISQYLAIKDNLELLSQKIKAKLDDDKFFRATERKLTSDSAVLPSTSSDSTILSVLASVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9M6</accession>
    <name>A0A2T6Z9M6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000671">
        <property type="protein sequence ID" value="PUU72200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9M6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="13890" checksum="99F5F19DE9F75400" modified="2018-07-18" version="1">MTQADEANGLADTAESPRKLQVRISPEYLLMLSSEAQHPADNVVVNMIIVEAHNVIANMPVVEARQESGQAATPSASSYKYSIPGSNLDLLSTDPTEGSFEGLVFGFVWIILPVVFRSGLHSLLLFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA94</accession>
    <name>A0A2T6ZA94_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1137747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000550">
        <property type="protein sequence ID" value="PUU72393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA94"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA94"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="24234" checksum="72F93EF35D77AB8A" modified="2018-07-18" version="1">MAPKVLFVLTSQKVHDETGRPIGWFLPEFAHPYHLLAPHITIDVASPAGGEAPLDPNSVEMFKTDDIAVKFLSEKQELWKNTIKLENVNAEDYDGIFFVGGHGPMFDIARAPIVVSLVKSLADANKLVAAVCHGSAALLDVKLSDGKLLVDGEPVTGFSNAEEDAIGFSGEMPFMLETDLVKNGAKYEKADQPLGAHVCIGRGGKLVTGQNPASGLGVGEKMKVALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAE7</accession>
    <name>A0A2T6ZAE7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1097198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000530">
        <property type="protein sequence ID" value="PUU72470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAE7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAE7"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="12338" checksum="8CB28940E90505DB" modified="2018-07-18" version="1">MTYTPTPAFLTAKANVDDLKETKGHDLMLLAYTLFKHTTIGDTQGTRPGMFSPKERKKFDAWGFTDGMTQEKTDELYINCSNHLVRDEPLVEENQALLKKIRELLGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAV8</accession>
    <name>A0A2T6ZAV8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000508">
        <property type="protein sequence ID" value="PUU72554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAV8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAV8"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="217" mass="24771" checksum="A25C7F3314E0B3A0" modified="2018-07-18" version="1">MPGPEHELTARTFDSIIKQKITDGGQEALIQHMGSTQYDGTYNAKEADASFKPLRARPGRLDWPTVILEVGVSEKPRRSSLDAKWWIENSGGAIRVVLLFFVNLSRKTIRIEMWKKDTIDNPQHTRDHNQQEVTGPTLKQTINITPTGITGAPLVLSFRDIFLRRRKKRRGENNYIITEDDIQKFYNLVWLPDVTSESESSAEEDQSSHSSDNYVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB16</accession>
    <name>A0A2T6ZB16_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eisosome component PIL1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1096764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000481">
        <property type="protein sequence ID" value="PUU72692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB16"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB16"/>
    <dbReference type="OrthoDB" id="5599269at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF4">
        <property type="entry name" value="PRIMARY COMPONENT OF EISOSOMES (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="361" mass="39777" checksum="E350838DDFB07CAE" modified="2018-07-18" version="1">MAILPPPYTPRKSSPSPKRSPDGSRTRSLSVRSSKSRSDAPAPPKRHRFTFASLRGNYQSELSKRLFRLIKSENYVINAYESAGQERQSIATQLSEWGEQTGDDAVSELSDKLGVILTEIGAQEDIFAQNLEDSRSVLKQIRNTEGGVQPSRDHKTKVQDEIARLKYKEPTSTKLVSLEQELVRAEAENLVAEAQLTNVTRAKLKEAYAQHFAAVVERAEKQAILAKHGRRILNLLNDTPVVPGDTHEPFNADRQARQILYDAEEDLRIWTLNLEEVSTQAHPVVGGVLDGKAAATSSLSPRPTELGNHPTQLGVHPAHRKASGASNHSNAGSSSSSAAADPPYPLSQEERRRREDMIVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB22</accession>
    <name>A0A2T6ZB22_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1096784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000483">
        <property type="protein sequence ID" value="PUU72685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB22"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB22"/>
    <dbReference type="OrthoDB" id="5305647at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU72685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="360" mass="39878" checksum="4896F0F9C203BED6" modified="2018-07-18" version="1">MSRSYSGPSNNLYNLSDNMDKSTAQQYACDSTSTTGSPSQASQTCSHISTSHIDTIEHYGCSLPLANTSSYRLSPPQFNTSLIAPSFDFDFASFPLGPYWGMGEGSIGNSTEGDYTDGHFEDENYVDGNPTLYTSFQDHRSDSGFNANHVTPSQEFPDYLTGSKPLIPEPGDYHYRTSSYTKGDRVPSDHGSNRGGSENPSASPKKHTNDAKVTKTKKAHQCTENNCGKRFGRSAELKRHKSSVHRKEIAAEERQELFECPHEGCERVGENGFKRKDNLVQHLRGVHGDQIGKKIGRRSTRMSTWSSTSNASAGSPTMATGYEQFSQDQQEEPFVYADQPIEEGSGTPPFSRDFWENLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB57</accession>
    <name>A0A2T6ZB57_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1136842</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000474">
        <property type="protein sequence ID" value="PUU72732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB57"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB57"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="779"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="817"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="882"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="917"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1013" mass="112690" checksum="11FD693E1ED601DB" modified="2018-07-18" version="1">MEPVNFQAQLLSNDFDPSKYRLLNEFLPSGEAQKSSSLVSSPHSDYPENLQDFVRLMESINAEGPYFQRQVHLGSKYLGSGAQFDVFGHQHLVRKGFPHFDLPYISKILDSELAPVVVAVNLLLILEHGNCSLRHFLFNHKRNIPNPPEQVLQKLGLDVSQGLSALHNAGIIHGDIKTDNVLVFPAEAPFFCIAKLSDFGFSILDMEKTRKIYSIGTPGWQAPELGDIGVSTNMLTKCDYFLLGLLILRTAVRAYDGYEKTSLEEVSGILKHANISQPMQNYIRDVTQYLLPSRPQERASDLGKVCDRLSQVDQVEFDRTGNWVQGRFDDDTPWKEYEMAPGASSMLLRTAQHYRSIAKENGIQPQNKSKRANYSWLPIYKFLEEVDADTYANIASHYVDGIDEVSQKPQVNITGDLVGQEISGYQLLGMCFSGQLHGSRSDIRARTLEDNDTKWQRNTVASGFLLGWKFAHENLEEHVLALSDFRQSGGYNAHYAYNMIEKESAYSPSGLLHEVQGPLEWLKNYPLHQAAALGQTTEVVRLVDDGYNINSLDINGETPLQRASMAGHASTTRCLVQRGADATLKSKLLGTIPLHWLFVFELSQVNNIADILVGREKENLGEESNVEADAFHFPFKWLSGSPIAWSVLSNRYEAISALLRLRSSLDSILDFFPSLPEWPENTDPYYDVHSNSIQKRNLFKAWIYNPILQYQHPICQNSAKYVAERGALEGLKELSSNKLDLRIVNRHGGELQTAVVKGDLDAVQRLIDSGADVNTSPSRKDTLLLAAIYAKNPDIVKLLLDNGAKVNFSPDALIEGPLQQAANIGNMQITMILLNAGADVNSQSQKPGHTGAALYEASGWGGIDMIEMLLAKGANYDIIGGINGTPLQRAACAERASLEKVKLLLEHGADPNVRVGYYETALQAAASTGKARVVKALLEAGADPNIEGGHFWTALQAAVIPSIRSHEILDILLERKVDVNTVGGSMGPPFKQWPHQGMRAWSRSYYEREHYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBW9</accession>
    <name>A0A2T6ZBW9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1136143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:34718"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:133977"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000430">
        <property type="protein sequence ID" value="PUU72990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBW9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBW9"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11031" checksum="AFCE34007B012829" modified="2018-07-18" version="1">MSTAAQQKVQAIINENPVAIFSKSYCPYCRVSKETFTEAGATFFVVELDKVDDGADLQAALKEINGQSTVPNIYINKEHIGGNSDLQAKKTQLPGLLKAAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCR1</accession>
    <name>A0A2T6ZCR1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1135475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000392">
        <property type="protein sequence ID" value="PUU73285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCR1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="417" mass="45333" checksum="8E54948C5283D52D" modified="2018-07-18" version="1">MTPFDDVILQHPTCPRPKEYPHTSILDGATDTSEEGVIMLNFLSVRPAITEPFNDGLLPHIICRPPKGCPHTSIFHGATESSEGGVLMPDFFGCLESTDFKVRFQENSLSVRPAITEPFNDGVLPHPICSLPKGRPHMSILHGATESLARGVIIPDSWSVKSVIMEPFYDVVLRHPICPLPKGRPHMSILHATTDTSEKGLDSGGVRHAITEPFYDVVLRHAVCPPPKGRPHTSILHGATESSEGGDSGGVRYAIMEPYNDSVLSHPICPPPKGHPHTSILHGATESSEVGVILPNSWSVSNAIMEPFYDVILRHPICPPPKRYPHMSILHGATESSEGGIPGALGLLLPNLLTTAFYTILSVHCQKDVPIRAFSMGLQSLLKGRSLCRVFLVQGVWRALTLKPDSGGVRHAIVKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCS4</accession>
    <name>A0A2T6ZCS4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1069142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000396">
        <property type="protein sequence ID" value="PUU73246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCS4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="215" mass="22632" checksum="42769DCA282530A1" modified="2018-07-18" version="1">MELPHPAPYILTLMIIGALLPIGPLMKIGQRVHNRPVDTDEPELDSDEAVYRCHNSSNSVVPALDSSFALSSAITSTNRPNGLANTAEHVRKVTHGEPVINSSIESEPDKLHREINQSRQPSTRPSLANSPPLLAHNLSHDPASAASNSYRHPAACHDAMVNMIVADTGDALADMPVVDAGPESGPAATLQASSGGYSIPSSTALSAEMDIVSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDP8</accession>
    <name>A0A2T6ZDP8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000364">
        <property type="protein sequence ID" value="PUU73599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDP8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12368" checksum="6A1DE65A46AA38F7" modified="2018-07-18" version="1">MQMEDFIITLSAVEWAEGDSSPEICNASMFNSAYDYVGKDGNVLVANFEQSDIERGGTSDKGKVALLECFNASTKDQVSGPTSPVPEQAVNTERPFSRERSNCGSETLHRKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDU2</accession>
    <name>A0A2T6ZDU2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDU2"/>
    <dbReference type="OrthoDB" id="10037309at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="198" mass="21464" checksum="E3F002BC1623DAC5" modified="2018-07-18" version="1">MSIEYFTLELVEEMAAAFLGMTIIGTGGTEEPQQAPGAASDLMSTLERLSPPESPPPLDSIKVDEALECKICFGNEINVRFKECTHGACSACTLGIWRSKAERHNPLPSWFPCHLCRAEINRLGALIPVSGDENGDAGSASLGSGEEVIMSSVIFRVSEWVDIGEWVKGLSKEWSDYVRKANEELGNTQEGLEGTDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE15</accession>
    <name>A0A2T6ZE15_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000349">
        <property type="protein sequence ID" value="PUU73735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE15"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE15"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1257" mass="139118" checksum="8388C331C5A1B3F5" modified="2018-07-18" version="1">MAHSQGFGGHELSSNSRTQLSQFNHPYTPVDTLKPQILPKPEANLIIGLNDQNCNKPWKPFTLRAPTLLASLLITVALIALIEYINKISIEEKALFFAEEAEGFPVGVVFCYRYLPQMIVVVLGVGWAAVDLDVKRLEPYFQLSKPEGATASNSIFLHYPFDFIGFVPINAARKGHWNVFWAGLALCVIFWGIVPLNSSLLTTQHVTRDIETSFKPIKKLATFDDQQEAMSGYFLYTSYGITWLGEKVHSFMTLALIAIPFKPASYSRAQSYITRGNESWTAQARVYQTELACTPCEIKEIKSPNGTEYTFSTDKCVYSTDPLPNPNATRNMMYIWLTEGECREPNLFLALWAKSRDAHNRSDELDLNTLYCKPSYHYQTHEVTVDGTNGAILRAVPVGGRTNFTQEDKIIDIFEFERNVGLVATSSGGSPRHFSNQAPRSVSSFEDWGLDSPTPQIPYVVGLSPEKKFDDFKDPTTFRDGLDRMHKLFFNTALETMLVSDSGGEEVVGKRRVTSIGIVVVPQFAHILAGFLGLVVICLGGVFLVSYNRQNNLASDPDTLGTKMALVANSETLLRDFSGADECPAPDLCIEPRKYKLGTWGGRGEYRLDVVMGRDNLLVQTPHASCTIPHSGKLVGPIELTIWTGLAATFVNIALFTLLIVLYKSALRWNGLPTLSDSQLVSQIIFSFIPTVITTILEPFWVLVGRYLALYQPYTELRRGNASPASSLGLKYTNIPPVLIAPRALRHGHIFLFLASMMVITANFLAVVLGGIFDQSSRPLTFDAMVTYPFTTSIDTEIQRVNSREGFPVETFAKDLEEHWLVVSTNVVEGTDLPPWVTDEFYFLPFEWESGNKAGLRTSVTQGYGGNLTCRLLASNNFQQIFNPRVEVSNMAAFGVNVIVPISDGGSVLCSNNQTMNADSLKQGTHPFAMEWTWGLDASDGSDQKAVQACGSQILAGWGRGEADHDASSAPARTSVTMQSNTTIICRQQISTGEFMVTVDGEGNVKRTKLIGGLQYDDPRIFNRSTSVGSFTAQLAMLLRVPPKQGFDVGIMHSDDISPCFPQFIGGHLINNTLSDPSTPSPSFEDAQHALSKFYKRFFTIVLAMNQDTIFVPAGNVSRSEVGQLVSFQPRMSMDPVIFYIAVAILGFQLIAGTIIFVTPRRFLPRFPYTLASEISFFHASSALSDVAGTANMNSAMRSRHLKRLGGRYGYGRFKGWDGEMHVGIERMGLIEGYTESETMTMSRTVLAGEDNLELIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEC2</accession>
    <name>A0A2T6ZEC2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000342">
        <property type="protein sequence ID" value="PUU73832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEC2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="97" mass="11340" checksum="82BC356B3314126A" modified="2018-07-18" version="1">MLGELDAGRLWGVGVLCRDRWKDGRKVSLLLYILLSLPLISWLSAVIVSKQLNEKKFPTLSCELAIKGFCAFYSWRFVSFCRRTFCRRHNRRFAVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEJ3</accession>
    <name>A0A2T6ZEJ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1094046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000334">
        <property type="protein sequence ID" value="PUU73913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEJ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEJ3"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0158">Chromosome</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="134" mass="15687" checksum="5F189472CC1DBFF9" modified="2018-07-18" version="1">MAKICAAIQDMKKNAVKREQGRKEMQDVVTQDNLVEIRNRRPQRLGDIYVRPTLEGKRVPGEVEIHQNGLRYQSPVRNDHRIDVLLSNVKHPFFQPCAHELIVLIHLKDPIMVGTKKIKDVQFYREATDIQFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZES9</accession>
    <name>A0A2T6ZES9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000328">
        <property type="protein sequence ID" value="PUU73995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZES9"/>
    <dbReference type="OrthoDB" id="5356990at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="15675" checksum="E2D01AEB044A1EC1" modified="2018-07-18" version="1">MSAQILETLTTSQERALETLKEATDLLSNCHTHNIAAIDINLGEFVGLYILTIDCGEGDIIWQVEMGKRALLLSGTMDRGLSAGVDVVSPTRASLPFLQPRHIWGEAICNELLQLIRIADPRQNWWKDDSVFKNYEPTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF53</accession>
    <name>A0A2T6ZF53_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1196473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000322">
        <property type="protein sequence ID" value="PUU74127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF53"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="167" mass="18624" checksum="0085450CFE5D5EC9" modified="2018-07-18" version="1">MANFNSHAEANLAQQIANLDLSLINLSLQQQKALQEMEATLATLQESVTKHQGEQDLLSPFVKQVTTGITIARERLANFEMQEFGDLDIYEGEYDSDYDSEFEDTQSDAGSVFYAALGRMWGEPQGEPLGPVQGAPQEGPRQGGRKGYLVFVFLIFLLAGFYFFNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFC5</accession>
    <name>A0A2T6ZFC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_891341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000318">
        <property type="protein sequence ID" value="PUU74179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFC5"/>
    <dbReference type="OrthoDB" id="5475932at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="79" mass="8911" checksum="1916EE340F6A1498" modified="2018-07-18" version="1" fragment="single">PNPKGPLPKSTDRALPPTEPSTLPQLPSMWLLKFRYPPKETNIHPNNTRSALSIAVDRYFIIASLICLFAFLIYFLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFE6</accession>
    <name>A0A2T6ZFE6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1103607</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFE6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFE6"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="206"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="659" mass="72009" checksum="BE4C5122CDC09359" modified="2018-07-18" version="1">MGTVMIVGEQVTVVCFNWWKMRLQGATFGLARTLARLHASPSRLSMKQLLTRPPSSVAFLLFTQSLLSSTTHSGLLLTSFCSVSCSPHSHFIPLLLISHPPFPCLHLTLTFYGPAIMVSPRRSSRARSTANPAPVSHSSSSSSTSSNRGRLQKHHDNDSHGDHDIGHSRRGDHGGIPFESHLESTAEVNGTGDDEIDDAGSQEDEVTRCICGHQEYQGGDDDQADSDGLFIQCDQCHVWQHGFCVGITDTASTPENYYCERCKPELHKSGTSKSGMRTSLYLPVHSEPSSPINNKEIPHKRRTTMNSRDAEYDDAILKKVLEESKNDKLSGSSRGTSSRSRKRGTSEGSDEPKQDSKRRRTSDSPDTPVNGPIESSDEKSGKGITAPSSTKKSRGTSSRHSNINSSATGKRTSTRNRNGDKNKEARKEDEYPPPRSNNRATNKPVVEEVILPPPVTETAPDTPQQPAKRSARNGNTSGHGGRRRGNYRHRQSEDPGDNGGASPHVMTRDHSSAGGNQGSKPMDHGTIIDKPTKPRIPQARMSINEMGRRVRGISDFITRTQIEMASSRASDIYAYLAWMEEKGTPVSNATTPQNPETPTSSSSGDKTLPQIQINGNGTGKILEKAVEALSSNIQPGALEMMELLSSKINRWQQQYGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFM2</accession>
    <name>A0A2T6ZFM2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFM2"/>
    <dbReference type="OrthoDB" id="5419268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="265" mass="30607" checksum="5EA125B5BFC5CB83" modified="2018-07-18" version="1">MVYRNFMPGQYHSILEWINATILSSIGRKKSARLEDPGKIVQTGYSAGSRSHPQFDWAKNLLSKTYSTEEQQEIGYLESSIFALFWNMARKLIHNNISKDIEEFLETGIARMDNKGKQKANNTYTIQHEQEIYEFNQGELAPPVGFFASNYSRAIHKETAPHKYSLFWTTERSLEANQGGNFFISDYGIRIRGAENTLVAWQTRMFHGTSLARLDSIESYTGKGQVGLSIVSPNRLPKIWERYMNEGIDEEELKRELEEGKEEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG71</accession>
    <name>A0A2T6ZG71_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1092758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG71"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="25818" checksum="4EBE143C00BADAF8" modified="2018-07-18" version="1">MEPLLTPYPIISLLSTHITQDDLINLSLTSQSAHHNLFLASRAHWKNLYSKTAPPTSCTFTASKTGYHRFSVALKELQVGRCIRCFTAVCKGCVYDTSLHKRLSNWMRACTLRKRLRKVCNTCESRRPVRRVKVCGCEHAGGVWICGECSVGVELSDDLSRREQQQMIRPGLANDVEVEICWGTNHRYGSNGKEEGVGEVQRQQQQQRGEDMVVVCSWCEGLAGGEFPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG85</accession>
    <name>A0A2T6ZG85_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG85"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG85"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="40221" checksum="0D3F73F1D025385D" modified="2018-07-18" version="1">MLKEMSGGEREKQLKELRVMPRGECGVKGDVVVTITTADGGSEGLRGSLPYFIIRTSSSETSPPADTLPATSATTPNNGKKTYIPRNLPLSPIEDPTKYIKYSKAHPKSGWPLKNAPLPDPELRLIKNPYAHMLAQPIRQEAEYHCRIPRAFLIRFKQLVHPETGETWVVPDGLRQTDDQRGRVQKGKWVLGNINMMRLLKVKRLAGANGKPVLPGDLAESVRDLMRKRVFDEAFDVKQRGGDKCFVRGEAIEEVGGVVEIGCVLDWELEEGAEGVIADTGEVDEVSGKVQRKEILVRINGRLCPVHHMRVMLGEEVAGKIKELWELDEGVTRVGLLRREGTLQLEIWLMKMRAYMGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG89</accession>
    <name>A0A2T6ZG89_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trs120/TRAPPC9 fourth Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG89"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG89"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="146" mass="16988" checksum="FC069741E697D118" modified="2018-07-18" version="1">MVETIRIEYIDVNVSVKQVEEQVCKISPAKYLVVTDNFLTLVTMLMNPITRTVILLLRLLLALRIPGANGVVGMALTIRFAFYRLLQQSLRPLEAREVRIMEIEFVVLCKDEFEISASVVEEGWYWEGWGRWRWAREGSETGWDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGB7</accession>
    <name>A0A2T6ZGB7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1032952</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="NESQ01000293">
        <property type="protein sequence ID" value="PUU74540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGB7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGB7"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="356"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU74540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="685" mass="74712" checksum="E052AE72BFA0E735" modified="2018-07-18" version="1">MTYGELDQLAINTIRILAVDATSAANSGHPGAPMGMAPFSHVLFNKFMKFNPKNPSWANRDRFVLSNGHGCMLQYALLHLFGYDLTIDDLKTFRKLGSKTPGHPESTDTPGVEVTTGPLGQGFSNAVGLAIAQAHTAAVFNKPGYDLVDNYTYLYFGDGCAMEGISSEAASTAGHLRLGNLIAIYDDNHISIDGDTNCAFTEDVLKRFEAYGWHTLHVKDGDHDLEGIEKAIAEAKTVTDKPSVIKLTTTIGFGSKLEGTGGVHGNPLKADDAKNVKVKFGFDPEKSFDVPSRVYEAYGETASKGAAAEQEWKQLFAKYKGEYPKEAEDFSRRLDGRLPEGWEKHLPTYKSTDAAVASRKLSETVLTKLYPIIPELIGGSADLTGSNLTRAKEAIDFQPPSTKLGDYAGRYIRYGVREHAMAGIMNGLAAYGTIIPYGGTFLNFVSYAAGSVRLSALSHVRCIHVATHDSIGLGEDGPTHQPIETLAHFRALPNCMVWRPADGNEVSAAYYVALTSKQTPSIIALSRQNLPQLENSTIERAIKGGYVAVEAENADITLISTGSEVGICVDAVKYLKDNHNLVARVVSLPCWEVFDTQDREYRLSVIPDGIPVLSVEVMSTLGWEKYSHEQFGLNRFGASGPYKQVYEKFEFTPAGISKRAVATVGFWKEVKPIRSPINKAFIQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGE7</accession>
    <name>A0A2T6ZGE7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000292">
        <property type="protein sequence ID" value="PUU74555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGE7"/>
    <dbReference type="OrthoDB" id="5422807at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015431938" evidence="1">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="18348" checksum="FFE945CCA765A4AA" modified="2018-07-18" version="1">MKFTSSILLLVLPALSLARPSPQTADEATSPPAPCVDGERTCDAGNTWSLCIGGRFVSQGVNDADSECTQLQVRGDNSDTSVIDAFSGLRFVGDLGAISGGGIGIQSTDGGPREYPLLAGPSMNITLIVKDAPDSFGNGTAGNNGTATPLRKRDNVRCIRVCNNGRCAVENCELVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH48</accession>
    <name>A0A2T6ZH48_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_998279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000272">
        <property type="protein sequence ID" value="PUU74817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH48"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH48"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="33094" checksum="C55F98FF4CF01676" modified="2018-07-18" version="1">MDAETAIQNAPLVELGRYGMPQSWACVRVGNIPYNVTTSELTEFLGKNSNIIPESTENVGVHVIMDRSTGKTMDAFVEFMTPKDAWKCVARRKSRVLGNRHLTLDVVDPSDLMKEIFPRAKGVNWDGVVPLVSRDPEYAGRSPEILGREELVLIVNHARTPHRSPFSRKCLQRPFQSLLSIVSKFPWFAVDFYTVEQRDYIYQALLSAVEILKRHIKRGKAMPNLDQELLKSLVRVGAVCSGFTDIQRHELVKVAEFGAEGIYLEEIMPGFHIFRALGRRPGADRKVLEVCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHB3</accession>
    <name>A0A2T6ZHB3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1103236</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000264">
        <property type="protein sequence ID" value="PUU74883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHB3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHB3"/>
    <dbReference type="OrthoDB" id="4738706at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="454"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="611" mass="66041" checksum="110CC8651C904C17" modified="2018-07-18" version="1">MAASSSQAPTSASIPTKDTTGMADFVLFDDDPLYQEYRPRYDNGGFPPSDVGSYVAMLEQPGEDQQSKFYMAELQPGTTSFETYPPYAYDDVQLPMGYEPGPAPGVLIHPPTLPYSPHGNVPGSLEYRTPISPATSAGGLEGSSAGSEAGSTGSPYPPQIDDPFNPVYAGTDIDPSLIMPSPTQQFEDPCSAASSRGSPSWHSAHSPPPTSNPSSPELGKRNGGRLSPLRQYRTAPYPSRRLSVTSQSSSRSHGSPSGLALELEDIYAAVPGDIPRRAPSSSGSGAGKDTLCPECKKSFRDLKAHQLTHQLERPVKCPIATCEYSKKGFARKYDCQRHTLTHYKGTMVCGFCPGSGSAAEKSFNRADVFKRHLMSVHNVEQTPPNSRKRPPTKASPAEDRYAGAYVTGKCSTCSITFATAQQFYEHLDECVLSKVVQEEPAAAFNEMNLDSVKLSDMEPSSSNPADPTSSDSEDEDEKDTTFSPATNKSVTKIRTKKGPIKRSGSGAGSTQSGKTKTIRRKRNNFPAGWGCQPEQMVTKRRCLMVFDGPKLLCRDEMMMSNEWEVRAQLGGSGGSDAYVSDLDFWTLRRAEAFLDVAPSRNPQGAAVGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHJ6</accession>
    <name>A0A2T6ZHJ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1091407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHJ6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="8489" checksum="654D8B366F267535" modified="2018-07-18" version="1">MYGGGMLYSLCWVVGLKQFVFVFFLLLYYSSVIAKRRKLNTLLTCPVCMIGICWKKTTYPLLSTVGTIRKNIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHU0</accession>
    <name>A0A2T6ZHU0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1091171</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHU0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHU0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="212"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="635" mass="69080" checksum="3F622320A4EF0182" modified="2018-07-18" version="1">MDPIAEPHPGSGNGNSGYAFITHSQETLPLNLPPSIDNATLARRRRRRTSAHDQAILEEEYRKCDRPDKSKRREITAKVQMGEKEVQIWFQNKRQSTRRKSKPLLPHEIIPHNSQNSISSSQQSLFESSQSFSSSQTQESNSNSNYDHNSQNNSSTVGGGGSIRRSSASFSSVATAAQFPDTFSDDVLHSQGGGEYLGVSDVDDDDEEPVRQSHQQSYQVAQRKPSSTATGQTSGHKSNNLSLASVISSPSCPENSHSATTEHHYHQHQKTSLVIDGEGEQGEGEDGHEMFTQITMTTSAHNRLQRVLSSAPAPVHHYPPPGTSRRRTAPTTPKNPPRLLKRSSSIRLSTSLEGKASVVLEDEPSSPPPPLLALRTPKIQPSSVSRSALKRRTIDSKVWEFCCDNQAVIRSPCQPHDEPSEATEALGLVRERGNSSAHKPLLKDNSVGNSLGMVKPKKNLQKAIPSSSPIKAKKSRKIISAKSARPKPALSNNANANPSTATAAAGNSSKKPRTNPLLPEPGQDSDKENRPPGAPKKKRPAGKNKTPRRGSNKSSSDKEKRRVLEETRSEGMRIFYDVPPTSSQVCETEYELPGASGGGSQSFFDESSQESAGPGRVDEMECVENLLSLRGGVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIP7</accession>
    <name>A0A2T6ZIP7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1090533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIP7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="134" mass="15167" checksum="A6D2FB3906554D84" modified="2018-07-18" version="1" fragment="single">MFPVIDSPRVLALYPLTSFISAQRGMPSLLLPLSRRCLLRVHHARQAGRKKISNINVFCVPLLLCHLGQYMLLILLFRRVQKSRLRTSMCFCCHPGGTLLWSSICIVVVLYFTATRVPVPVKTTSRVGLFTNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJV9</accession>
    <name>A0A2T6ZJV9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">pectin lyase</fullName>
            <ecNumber evidence="8">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1102765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJV9"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF67">
        <property type="entry name" value="PECTIN LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="35"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU75777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="321" mass="33576" checksum="4AB3EAE9B97EA5B1" modified="2018-07-18" version="1">MLKKEYNFIGSQGTVTEAGCRPASNTCPNSGGQDAINGPSWCTKSSYPSIQVTYDKAGTTYIDVKSNKSIVGKGSAGVIRGIGLRIANGVSNVIIQNVHFTELNPKYIWGGDAITLAGSDMFSLIGRQMIVTGYTQAGRVTISNNEFDGNTNWSATCNGDHYWTMLFLGSSDLITLVGNYIHNCSGRAPKIGGADTSNIIIHAVNNYFSSIGGHAFDLETGGMALIEGNVFESVTKTITPTSASAGGSVFNVYDSSDTSICNTALGRACVQNSVSGSGYWTKYTTSSFLTNMSGKNVQAAAPVSGVKASVMSNSGVGHLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJY3</accession>
    <name>A0A2T6ZJY3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJY3"/>
    <dbReference type="OrthoDB" id="5370336at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="33253" checksum="206A5B537CE48AC9" modified="2018-07-18" version="1">MDPIPELNLPGLSPTAARAFASDRFASDGGLIPDGTPREIYMYHPRDFQDENRELIFRRRILHYFKGKSFVECIPCMIWLLNNWSKEFGTFCLDWANTFITGLGPGYFDNLRFQAPQDVTSWDEVANPTISKPSKRKTSAGNNTKTNANTEAPLPNPKLATLWCKINVRHLVRRLEVCYAPRIYTFSKWTTSGTSRNQYYDPPLHPVPSLEERLCFWTERETMYVLKDMREAAKKISAKEFVHLDVQTLLKKTDINSLVDRYFYLLDKGEFKFMERVGARGNVLGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLF8</accession>
    <name>A0A2T6ZLF8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1088392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLF8"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="106"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="267"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="713"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="940"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU76327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1149" mass="130660" checksum="384107B1F26A4B2D" modified="2018-07-18" version="1">MPSLVHKRPAQHLTDNSESEELLSSLGSPPPSRNPKRARTIREEIASDDEVSEEDLGGEESDVLVKPDMDGSLLSEADSDQEEEEVMDHRGGEVERNSQPFQPGSIVRIKAENFVTYTAVEFFPGPNLNMVIGPNGTGKSTIVCAICLGLGSSPANLGRAKEISEFVKHGCETATIEIELQGKENERNPIIKRKIGRENNTSTFTLNGSSSTSGKITKLVKSYNIQIDNLCQFLPQDRVVEFAGLTAVDLLTHTQRAAAPPEILGHHENLKKLGKRQKELLNELEIDRNQLTSMEARQAALQQDVERLRERQEIIKRIELLDKARPFVKYREARGLAKDAKDASKVAERELRELEQQVEPMTEAPKAKRRYQKALERCVAAKKRELEAKEEAVTEFKDDVMGKADEKITEITNKMDAARSAEQSRKQQIAREKEKIAKLRKQLEEGPPEVDLAYYNGKISDSNHEVRDMKERIDDIDSEIKPMVERANQINGQISRTNKDLQDLNSVIGVRERMLERMSRDTHRVWQWLKTHQGDFEQEILGPPVLTCNVTDPKYADVVESQLGKNDKLALIAQNKNDYRKLLDVCFGSGPESLKLRDVTIRENSNVPIPPLPMASEEARGLGFDGFTIDFIDGPAPVISMLCQECRIHTTPISFKEFTAAQNKNMESTRISRWITGRNMYTLRRRYNQVMTNVTSIRNAQAFAAQQVDTQAEQEIRRSIGEMESDLEDVKKKIDELKDSRDTFVAKYKAAQTANQKIKAEKATRQQEATKYVKNKATLASAEDDLRRKMGGGEEYKESMKRWRSQKEELVMERAVDAQKFANLVKSLVAIHNELILCQIRLVEAGSDAEILQRRIEDGLRDLQAKKTESTSLAQHATECAARARALQGACRKIIQGLSPEESEFMNQIPPEKNAEDIENDIEAENARLDLLHEGNPNAIKQYEDRATRIRNLEDKITEREKNLEKHSAAIAELRSKWEPVIDRLVAKISTAFSKSFEKINCAGEVRVHKEEDEYDKWAIQILVKFRANESLQILNNQRQSGGERAVSTVFYLMALQSLARSPFRVVDEINQGMDPRNERLVHHRMVSIACQEYTSQYFLITPKLLPDLSYHKRMKVHCIFSGDWLQEDTRLDPDKYLRIGARMRAMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM18</accession>
    <name>A0A2T6ZM18_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1088116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000185">
        <property type="protein sequence ID" value="PUU76535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM18"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="8212" checksum="81D9CA8B85F8B228" modified="2018-07-18" version="1">MPSRALLSWTSLSRSFLLPPASQPHYPAITTSPNNHHPTTPPLPSFLRSLKQEPHGEAVGAIFVTLYHTQIVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMN2</accession>
    <name>A0A2T6ZMN2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Translation protein SH3-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1102188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMN2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMN2"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_A">
        <property type="entry name" value="Ribosomal_uL24_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="136" mass="15411" checksum="B2D62963E021C98A" modified="2018-07-18" version="1">MTKLNAGIAASRRKSRKAHFSAPSSVRRIIMSAPLSKELREKHNVRSIPIRKDDEVTITRGSFKGREGKVVSVYRLKYVIHIERVTREKVNGQSVPIGIHPSKVQITKLKLDKDRESILERKGGKAKESEKGKNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMV5</accession>
    <name>A0A2T6ZMV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1102158</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZMV5"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="299"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU76817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1434" mass="160500" checksum="36984996DB8F0E25" modified="2018-07-18" version="1">MSNPHQWARPFQHTQARPQPWSNQPGQDAQNSLARSSRLDIPNVVRPPPARQPPPDPFFQQSHSRTATEKPPVIDLTGSNPSPFQRGLINTPKMDGVFNIPPVTPTVIETPVVVEPVRPYDGALCSRSSIQNSRTRKRLKFAPQACPPASPQFIQPSKVYQGAKNSSTPPALSRGNSSSRQKQIQPQPSKSDFSKPNPRRDNKPKPYLLEAPPGALMFPGSSCSDFFPWKGNHPEDRVTDAQARNGQYDKLYVGKGNASARSSLVPSLKGKSALPSLSSLFLTVLDKRQKYNRLTTPPTFKPPPRVTLPDMRREAWLRDLASPLVPLRRLSRTIPHGLKGPILLDQCAAKSIPTARAVWFARCVGANELRGLKRKGVGSFAVGSETKWLKEWTGQVTRFLERTISECGSSSDLWKQKMVYAVRLSAHLFGENLLDRTLFLEWYLSYLETCSLDMLPMAYLMLSIYWDELLKTRRLGRRLAEALLGKAEAILATEDKEIYAPLMQKLSILLTDILFSHRESLIVSNSWELYQSILEACVDKRCSIVRSCLQNISQRNKNLLSPMQARQNGSVSSGQRKLINMLDSIAMPYNIDEIWGKCRSLEVEEDQLVRCLCQWATTSLRVGKHRIYIIAGLLGCARRGGINVQDHMKSFLEGFGSNVKGSKDDAYLLVSELVRSKTFSVALYMKWLISRGILSEYTITQESPCHVRLLAEVSVTSAPSHIRNLRSILLSDHGFSVEDEARSLEVSKQILSSKMPRVFYGDSRAGVSVEKFTTEELGYFGSLNRAVIYELGLWIRENVRKHVVKGAPVGRDNWRDLSVEVGITAVRTEEFVMIRQLLEMFKDFLILAEVVKMVTSSDSSATLSSAADTVSYNIEVFSSLGAVKDNLQLLYNRYKKLQMRRTLEKYVLVSLVDLASFPGAQADIRRELESELANYDKRFPRASVTHSPVSENMGDMFEHGTADSNEEIDRLLRNGATIDKHNLSRLFETIVSRMETSFDDRESVGALSSSAAYLIKLRQFDPLVFDELMCGWVTRLLQSSSRPPLLQTLSVLVAGSCLQLDVIVQATLSVLRPQAKSSNPATGEIAAQTLDILVNDGTDGLSLSPFELYSLKRKRKLFTLKFVDKFVQLIRQSIQICAVASSPDTKNRVRGLILSPPVLEFLRGLATAQPDILISDIVEPLSKTAETSLLQWLRVLIDHLLDDQENGGLYPLFFPFESSVMVAYIGLDNTDLDPEVQVAHLIQYANDFSIGLCQLKMRIIFDAENKNASFRPSGDHTGSSENPLMKPFFQGIASTFKDRVTIWTDLVSVLNQECAYQVFHAHIRGYAEELVLNSPTFPPVRLCLGPLEPSLAEGRESGETLARALLSVIEATAYSIPKQGIASIATLLVDKLNMIIQSITLQEDELEKAEHAAVPEVFWNDSLAESRCWYVYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMY2</accession>
    <name>A0A2T6ZMY2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1109243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMY2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMY2"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="360"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="762" mass="86971" checksum="43384E2D318CB299" modified="2018-07-18" version="1">MFRYEEPTPEDRWYYFFQRAERILKEAEARKGQKPLNKPPRLQYISQHNFLKGAEGGEGGSESGKRTVRILSNIAYTEHPPCVVPFATLEKKFLDDLRLEIAHRGSYIILRAIVDPNNYVSVTTIAEDENGGVELVEIYNQDGRKSPASIMPEGQVFILKEPYLKTTSHGGPGIRVDHVSDIIFLDGEDERIPEKWRPRIRLLARRSLDWKDDGNRFYKEKQYFEAAQCYTKGLQVVEPGSASDIVLLLNRAQAYLELGYNEKALLDADKALSYEPLNQKALYRSALACYGEGDYESARARLVKLLKEFPENKNAKEKLLRTFRRLQEQRKGEYEFLKMRNEVKEWGDKRGKLDCAEYVGPVRIGDAGDKGRGLFATRDVKFGDLLLCSKAFNVCHKEVADARIEILFNFKARKGQAGTHSHLVRELIQVLYHNPKKAKEFYKLDSGDYQRVRGGMADGLSVVDSHLVMRIMLRNCFDCIRHSFFDDHLENLFKEKTEVEKMIAKTSPTGAVEGSGLWIMPSYINHSCWPNSARSFLGDLLIVRAARDIHEGEEITINYIEKLFSIQKRQQALYSGWGFNCKCTLCEIETAEQQEAQDKRQELVEKALKFETYLRQSVNKSNSGIAPMITLINGIEATYSKPEFVHPRVRLLSSTKILQEFLVRAERPADVFLLAKQALNGLGFKITTKGGKVVIERYGYMCYPVMHMFMHIITAGAAMGDLWTATLWRNAAVNVYEVLAGEKESFFDVFGRALLEAGAPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNK9</accession>
    <name>A0A2T6ZNK9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_197806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNK9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="91" mass="10528" checksum="B774E2191E0FE6E2" modified="2018-07-18" version="1">MPLSRSFFCLVYFLSVLLFNMVFSLSLSYFGIITTVSYPEALLLPFSVSPPIQFSFWPCSLSEVSSFSLLTLKTLEIFMMGYDLLRFFFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNY4</accession>
    <name>A0A2T6ZNY4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1128578</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZNY4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF5">
        <property type="entry name" value="HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25503">
        <property type="entry name" value="TPR_CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="139"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="1926"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="2306"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1694"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1694"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1711"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="2360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU77187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2439" mass="268578" checksum="761E54887F3DB703" modified="2018-07-18" version="1">MSTGSGSSRGSRHGGSLYSSQVAVNALSNSPRINRVPAMPPQQTPTPTQAPVSVSPLIGSPNSMGPSINPTSSLLVSQLLAGSASSVVDPGAAATPFGMIVVGDGTVQNEIVKKKNEDAAATRRDSITELEETRDLRDISEMMESGGMAFPTVPGYEDLRPVYSIRLTEVCVIAQNHIQVFRAKSISTGAPVVLKLCTVNHLDTLARLRHEWKLLSEANASSSRASVHSQSTASAGAAPNASNSGLNSLPSTSTSLTSLPSVVRAFAWEYLPDGGMTLIYDDEPTHMTVREMFLPDTLPLYVGTSGQAMPISPRPFVAKPRTQSDLVKILSVFSDVVHILAVAHRAGITHNNVNTHSILVTKTLKTTKAGVPVLGKLGGWHLASRLEREDPGRAEGTMLRGLNPAPLQYIAPECTGRMNRSIDYRADFYSLGVALYELIVGFLPFKSADPLELIHQHIAQQPVPPTDVNASIPTAVSAVVMKLLAKNAEDRYQIASGLKADLDMLIRRMTEGRSLEGMRVGELDTTSRFVITEKLYGREEAVSILKGAYEKCSKQGGCSMVMVRGGSGVGKSRLVNEIQRPVAENRGYFTSGKFDQYKRGFSFFTLVQTLQDLVRQVLSESVQSLSRWRTETIRALDGDAAVLADVIPELKLLLGPDYRFEPLANLGPVERENRFREVMGRFLAVFGRRGLVVFLDDLQWCSQNELNFISGIADEANRKMREWRAGTMSIGDTGAVGKWGIKQSREPGAWGLLVIGTYRDSEIGQDHPLPPMLEYVRTRAGVDIVDIKLGPLDQDSVRKIIGDTLHRDPDYGRLREDAEMQTLTELVYAKTCGNAFFVMQLLKSLYRGGYIVFDFGAKGGGQWRFNLTNIEAEDLPPTVVDLLVKQMLKLSGPTRTAMMLAACIGTDNVGLQSLAVAAGKKPEEMASDLWGALDAGLLLPTSGNYKIPLALGENIPMHGGGDSNTILSNGPSGDSYFPARFSPSPSDQEEAVTYRFLHDRVQQAAYSLIPKNERAGVHRMIGTRLLEKVPEEDLGGMLYEIVNQLNHWLSPLEKDERHTLMELNLRAGKKAITATAFDAALSYFLTAKQLLDDHEKEEEVAGAVTTKLKKRFSMGWETRPGAAPDKEPDTEDLGLEINLSLIEGYFAHQKYEGSINLADAVFPKCTKPRDKIRCLVHKMSCLLVQGKLNETIETGLLGLGVLNWEVPLDDADAKSHADMMRPRILMDVAQIKALEKMHRLKDENLILLQELISSLLLPIYMSRPALLEAVCFTSVAISLEFGISTAGAYPMLMTGVILSAEGTQEAHLKSFAYGRLAINLIEKDTIMCPAAPAIYEVYAGHIGIFHCSMNEVLKSLHQAVTAGIALFNVDYTIFAMAEIPSFGMFGGENLSVVHSKMVATKPSIRKFKQLTGMWWLSLPLQFLLNLRGLGNPDPLCFEGEELGDSKALSKLLSSESMTHIYLYHMYRLIVAVIYGRYDIAADLATHYCEPMSGGVTGTFYASLTYFYSSIAFLHLYDTISGEQKDFLDRNIKQIQIWSTTAKGTFLHKSVLLEAELMRVQQPSQQLVILDKYDHAISLATSSGFTHDAAFISERCGSWLRAFSKRRAAPYLREAVRGYTAWGATNKAMELRKESAEDIAIKGYTESRPTMVRVDSDSMMATASINSALMNISPRPSPRSSRIYANDYGFDHSSLQNNSPSLASSRDLFAPDPHDDDATSHASSRRENEPSSLGSELDFRTVLKASLVISEGIHLEEVIVKLMKSVLQTAGADYGVLILEEDGNLHVETVGLLNQVSILEHEPLNTRADLVPVSIVNIVASLGEQILKDSDDPKFDATYGRDSYFQSRRAKSVLCMPIQNQLKTVGVLYLENKLVNHAFTRQRQELLNVLCTQAAVTIDKARLYRQMELAKKAAEEATAEKSSFLANMSHEIRTPFNALLSCSIFLLDTALSEQQREYVETIRNSAVLTLQIIDGILDFSKIEHGAIDFQVSPFSLRDCIESALQLVAEPAATKDLELAFRNKCSNIDTVHGDITRFRQCVINLIGNAVKFTQEGHILVTTRAEKLPNSGLWRVEVSVQDTGIGIPDNARDRLFRAFSQVDTSTRRTYGGTGLGLAISKKLAEMMGGDIWFESEEDVGSTFHLTITAEVTERTWCADKRLVGRKAIVADTHSLSSNILADELEVEGLTVTRTNTAEATLKQLHDHGIGYYEFALIDLSVDKTCLLVDQVNKFDHKIRVIMMSRFGASLPSDAQSYNIALSFVRPAPRSRYVQAIHDAMNPNKKKHLIPSKNQEVELLRSLARRHPLNILLAEDNPVNTRVALQHLKRMGYSAKHAKDGIEVLEMCEEAAERGDIFDVILMDIQMPRADGIETSLELGRRYVDGERPTIIALTANATANDREKCLQAGMFSHIAKPILPNDLATALMSTSPLQPSAIKRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP96</accession>
    <name>A0A2T6ZP96_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1101952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP96"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP96"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="234"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="398" mass="43795" checksum="4BB5624B1A8C2B6A" modified="2018-07-18" version="1">MPKSADLSWIDEAFPIPSQHSLNKSVRDIIAKEPKHSIVFRNIGKYILSLKGVEEPPSKKRKAGSEKNGVKKEVKGAGDVGLGKGDIVITVKEISFSIPTRKKFSLLLTNSSMSAVNAATGAVEFGVPWSEIQYVACLPVPDKAARQWNFCVFPKGAEGLGDGSADALVFTIPDGAPKTATGDGMGAGHDTSTYKSLLVAVFDSLLDRGTRVLEPDEKVFHSAVPQSHRKGEKAFHVKAHVGSKEGYLFFLKNGIMWAFKKPLIYFSFAAIESVSYTSITKRTLNLSIHVAEERGDAEFEFSMIDQEEYAGIDTYIKRNRLNDASMAEARRAKKHNVNGKEEEDGEDAGNLQKALEELEDEEEEDYVPGKDKDDDEDELGSELEDVNPDVPRAKRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPF1</accession>
    <name>A0A2T6ZPF1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1027308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPF1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPF1"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_uL30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="11"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11188" checksum="54C4221BAD20ACA0" modified="2018-07-18" version="1">MASVAPKMSWFKITLIRSGIGMTERQNGVLKALGLRHRMKTVYHPVSPDTAGMIMKVKELLAVSEVDKPLTQAEIHAKRQPPKGYYIEKQGIAREDIRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPT1</accession>
    <name>A0A2T6ZPT1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1128219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000151">
        <property type="protein sequence ID" value="PUU77482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPT1"/>
    <dbReference type="OrthoDB" id="3558706at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="254" mass="28050" checksum="B09326CA8ECA2F43" modified="2018-07-18" version="1">MSVSPETTTKLWEHAIKLRTERKADLGGWVSFVIPEDLIVAPVQVDAVTVVFLYIATGMKFSVAVHPVLGALFHYTPSILALANESLEEIRMLSRAVNQGKGMWVNRVFGKVNDRGVGRGLLDFTMFLIAMEGFLLSHGWPEGSRVDSISGAAGFMAVATVDVYVAISPTCIHAWRAHFVEVIVEGHLYEIQGTEPVINPPVFRHVKGNIIDSRCLITAPRLGSAPLYQPNAETLNTLIERLQPFNFVNHGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ12</accession>
    <name>A0A2T6ZQ12_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1065752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000149">
        <property type="protein sequence ID" value="PUU77556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ12"/>
    <dbReference type="OrthoDB" id="5353066at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="931"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="998" mass="106991" checksum="6687E5BD9C28900E" modified="2018-07-18" version="1">MAASRPRSQLLASAPSTESSPPPSPVPLHASASTQQSSSVEFNHHHRHQFLPLPSHQPLAASTSDHPNIPITLRNQSAARPRLPGRQETPPSPPNSVLLDQSPTSPSQPTLAEPIAEYPSSRQSITGTNVEGPGVTEHQTPPPSLKDRLARAFKGHKRGESDVSMSTNINPRDGASTSNHCRGDSDSTAVTSTITAPQNIKDNNNAVLQTYTARTNLGFSPTRPDFYSNQWASPIRPNSQNHYTYGHGGTKRRIMNGGEVRVEILPHPSVIAETSAYNEEEESNLFEEYQEQGGGDAQKSHGINRVSDAQHEDRYLIETPNPLRRGDQHSQSDLDNYLPPLNRSPATMGDSSPRSQTATTFETGLSGDNDSSRDSRERRYAEESTASFGFENFHVGSENDSYFAGLPSPNTDSGSARTGLYSSSGMASSGVLASLSQGDLSTQERSNSSLGGYTASKSSGGVVGRPGLSRNHSSSSHLLALQRGTQVPSSGSAGSPMEDALAKEIKRLSKISAGSGVSGVAIVVTSDEPASSFGEDSDDDADGQRWTKEEKGKGRAPRSVDSGNGGMPERNGSDLQLGNHGGRHRSGSGISRVSGWSLEGQSSGAGSGSEGGDDDSRGLLKGVDQAKKRKLKSQVAPEGMLVHEGDERYHFVYRMRRTPDETPILVPQYTFSSESSFPNRNALTLPIPAKISSPNLRGADHIPLATRYSSSPITKPEGALVRSPDLNDSYYGGMIQGDQADDSSARSERYSESHKSVVQSLSDNRIGELVHPAHRQASRVSQHNRGVVSMGSLEDIMGIGLRAMPSSGLSGARFAGSSLADTSDIGHPLEDTTAKSDINPKRVRMSDDITPAPQHYFEREPKVQNKRKSYHLPALGSRPMRPKNLRRSMTPHLYAPRPPGDSSKDLVDVESLPDNEQTLSYRKREKRAGRLLLGLCMLFPPLLLLVAWGGFDVTIEGLTSGQVKGVGRVEKRIAAWVGGTFAVCVVAGIIAGAVVVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQK5</accession>
    <name>A0A2T6ZQK5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_985783</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQK5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQK5"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="339"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="735"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="774"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="816" mass="93343" checksum="43931E943663A18E" modified="2018-07-18" version="1" fragment="single">RRRTSNGIRKENGFKQEESSSDDDVPLAKKTAAKLRNMSSPTQVKREKKNPPTPQGDSSDSDIPLAAAKLAKEKQRIAQKAAKTAKEIRAEKDKAVAAVGKANGVKKEESSDDDVPLAKKRKGAVQKPVESTKKAATGRKIKDVDTKLVITKGKGKTKEETPAEADEEEEEEYKWWENQAETDGTQKWTTLTHNGVLFPPAYEPLPKHVKMKYGGVEVTLPLEAEEVAGFFGAMLDTQHASNLTFAENFFKDFQAILKQSGGAKGPDGKNVNILSFQKCDFKPMYDYFEEKKAEKKALGAAGRKALKAEKDKAEEKYLHCYLDGRKEKVGNFRVEPPGLFRGRGEHPKTGMVKARVQPEQVTINIGKEATVPAPPPGHSWADVIHDNTVTWLATWKENINGNIKYVMLAATSSLKGMSDFKKFEKARELKNHIDRIREDYTRELKSELMADRQRATAMYLIDKLALRAGNEKSDDEADTVGCCSLRYEHITLEPPNIVVFDFLGKDSIRFYQKTPVIPQVFKNLKIFKKAPKTKGDMIFDRLDTTQLNKHLQNYMPGLSAKVFRTYNASWTMQEQLDEILNKGTVHEKYAAYNLANKKVAILCNHQRTVSITHETMMQRQEEKIKGLRYQKLRLKRMILSLEPTRKKKDPTFFKPDPEIDDEEWIKEHQVFLIEQEKDRVTKKFEKENEKLLENGEKALKDKELKERLQILKDMETEFKAENKTGKIEPKRGATVEKLESQIQKMEERIKKQETEAQVREDNKTVALGTSKINYIDPRLTVMFCKKYDVPIEKIFAKTLRDKFKWAIESADEDWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR50</accession>
    <name>A0A2T6ZR50_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000134">
        <property type="protein sequence ID" value="PUU77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR50"/>
    <dbReference type="OrthoDB" id="5343679at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015440272" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="61" mass="6367" checksum="A4E733363F35434C" modified="2018-07-18" version="1">MLLNTLPILALFLVLTHAAALANPFAEPDTSLEKRACVEDGCKCKPAVPSGVYCGFCPACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRD0</accession>
    <name>A0A2T6ZRD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1127309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRD0"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="204" mass="22456" checksum="748A449D0F860F87" modified="2018-07-18" version="1">MSVDYYAALEVSPQASQQEIREAYKKAALKNHPDRVSHNDPSRAARTRKFQQINDAYYTLSDPQRRRDYDSTRTYQSSHSNPQHAQSDWQDDQFADIFEEMMRDEGFAENTGEQTTPNGKFWGILGGLSGGVMGFIVANVPGMLAGAVAGNRLGAVRDSKGKSVYEVFQELPQSDRAKVGARILLSATLLSDLAAKVLAHAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSJ3</accession>
    <name>A0A2T6ZSJ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSJ3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11813" checksum="1E1B301613181DFE" modified="2018-07-18" version="1">MCVTIRYSFLSLALSLSLSIANLGIILFLVLYCTLLCQLKPHPQSSIHVPYRYCTVPIVIGNDNLPFLSIYCIIRAGRIVVVVVGVYSYIMCLVFLLLGAFTGHGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSR1</accession>
    <name>A0A2T6ZSR1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1101288</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSR1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSR1"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="417"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="688"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="808"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU78507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="837" mass="91234" checksum="FE16950E41195366" modified="2018-07-18" version="1">MTSRHSSSSGGPMPDSLVGNFRVGKEIGRGSFAVVFKGHHVKNPKSLAAVKVVQRGKLNRKLLENLESEIQILKKLNHSHIVALKDCSKNDKYIYIVMEYCSVGDLSTYPHVPGSGLHEVVARHFMKQLASALEYLRKFGLVHRDVKPQNLLLDPPTGYDSGAPLADFGFARNLPAASLADTLCGSPLYMAPEILRYEKYDATADLWKIETKGNTIEFPSSCTASEEIRSLICSLLRRNPLERMSFKEFFNHPVITGPIPGASVALVSEPMKKTKSMDTPKVGPTLIRRTPSLRAPSDGRELGTDREGRRTPHQTPPSPRLRQAVESSALPFAHPSPISATPPPRLADIRRATTQTVQASPPSPLARPTMDRYTKRNPTPREMHPLEEERVEKDYVFVDKQFVQVNAFADELATVRRNGMTPPSPSSSALSRRPTSGGQGATNAIAVTGRRQDGGYPRNSYERRYGPSPGSAPSPSPSSTRSTLARALELANLRLFGVSISPPRHSPPGVQSPYPTHPNNPASMVMVRNEGGPSDDDMQAVYSIEDAASRSDVVYNFAEVKLAQLIPGVPVPTHGLGLLPPSASEGDLGLPVEPAPSNELDLTPDAIVQLAEEALVLYVKALGILARAMDIAGAWWNTSNSRNDQTSPAMAVASMRMNNCVQWVRDRFNEVLEKADFVKRKLIEAQKLLPSSHPSHPNNQNDDSDGSLDASGDRVVVTPGVTAEKLMYDRALEMSRAAAVNELVGDDLNGCEVAYVTSIRMLEAVLENDSVDQNDGDGGMEEEDRMVVENYVSSIRKRLVSLRKKMSEVSKRSSGIHSIPGSPLQPSLSPLMGVSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT82</accession>
    <name>A0A2T6ZT82_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_981872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LCL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000110">
        <property type="protein sequence ID" value="PUU78676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT82"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT82"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="9908" checksum="1242D0190D98C320" modified="2018-07-18" version="1">MFGSSSSSNQRERGNVASDSSWYQQTYGGATCSNYLCPGTLACVDKPTHCPCAWPGVEEKFELDADGIAVCLSRGGRAGFVGRKVELARKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTZ3</accession>
    <name>A0A2T6ZTZ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_35540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTZ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTZ3"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU78874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="412" mass="45524" checksum="1FA9BF0DC518FC2B" modified="2018-07-18" version="1">MVGRIPIQQLSRATTITAFPSSFFSQRLPPSVVAARNLATISPPAQPSTGGAGGGKGTAIVLLNMGGPSTVPEVHDFLSRLFADGDLIPLGPLQKYLGPLIARRRTPKIEAQYSVIGGGSPIRRWSELQASETCKLLDKLHPSTAPHKPYVAFRYAAPLTEDTFLQMKADGVRRAVAFTQYPQYSCSTTGSSLNELWRLSKKFDEEGQIEWSVIDRWPAHKGFVEVVARHIEESLKTYAKEDRGKVVLLFSAHSLPMSVVNRGDPYPAEVAATVYAVMKRLGFKNPYRLVWQSQVGPSPWLGAQTSNTVEEYVKKGQTNLLLIPIAFTSDHIETLHELDLEIIAESKQPGIKRAESLNGDPLFIEALADIAKTHLESQSRTSIQMALRCPMCKSEKCAEQKRFFMSGKQIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU40</accession>
    <name>A0A2T6ZU40_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1125729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU40"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU40"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="249" mass="28208" checksum="FB8AA9BDA4CEED7A" modified="2018-07-18" version="1">MPPLNRSHWRDAYIYASDDRSTVLGGLWVAEGLTNANLYSMLQIFCLFTDTFDLYDSCEQLVERDGQPLKPGDYYIVTAGSITVTDEVTQIRTPSLPSGTRVASFTDAVRQRDRRCVITGRQARLAHLGGWDTFETTHIFPLAYEQQWLHSNYGDWITIPPAKVSDGTINSVQNGILLGSNIRCFFDAYKLAIDPDDNYKIVCFAPDAGDFKISGRHLDQTFLDNPHRPVDQVLRWHFRQAVLVNMRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU76</accession>
    <name>A0A2T6ZU76_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1125767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU76"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU76"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="447"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="565" mass="62999" checksum="EFAD7C96215D1CE5" modified="2018-07-18" version="1">MDRVQSDLVEWYKLETEFFHDHVRHTRYVEKARNRNEKVKEDWRNCEELGRGGFGIVHKQIEKATGDYRAVKAIDKRQPLSVDYPRELLVMAKLAKRPSLFVEFLGWFEGPEILYIVMEFLEEGDLTKHIGAPLPRETVRNISEQILEGLEVMHQQGIAHRDIKLANIFVVSMSLVWVKLGDFGVSNSPEVRGLDPNSETSEYTNSVNVWSLGCVIYELLAGTKLFVSEFQLSGYFYGKWPFPADRLRGLSPPTGDIGISLLKAMLAIQPQDRPTAADALNHAWLADLKSDNEHSGDDGVETIQSGYRREKPSRKRENTLSTTDRPKKKRSERNQISQADTRRTPGGLDLGAGAGFQSGGGPATRGTIIDTPVMVLLPSDAASTLNPEVETGPQKLELVPGSFQATNSKAPKALKRNKGILNPQTCPQNFAQTIPQRQTLTVEMVFTPGGRPKGQLNTHERERIKPGPTPPTRLFQEFPTSEHTLTDSAGPDNTIRKIQRTKPNTRGGGAGRSQHHTTANSMKNQNSRRHSTAGQDPDYGQTPHTRWNPSGDPDARPNPNLNPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUG0</accession>
    <name>A0A2T6ZUG0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosylmethionine-dependent methyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1100994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUG0"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="675"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="743" mass="80749" checksum="E05E37D0D5F795B2" modified="2018-07-18" version="1">MPTLPSFLSSKHNRNSATPTPPPSSASPRPAISGPLPQSYSSGRLSSHGGATVQLVPDNRSAAEQQEANNPSSSSSLSSYNPSSRKPLETSNTGGNSNISGGSNHGSRLPAGLSRRLSRNKHQSTPPSFPQQQQQQTESDHLDPYLQQSPHSPGPPPLSPGRPQSMLAPPQESEGEHYSVRRADTDPTQQQYSQPPHPQRQDSFQNPANLQVQLQQQQQQPQGNHTMANQAHNQPRRSMEQSNQIGPSREGSTLSQMNVYASSGRGNPNQQDYQTQAAGGTGGNQPPVYDPAKYEGQPIGRMTPENRAESRAGSAPEAINVQQLMQDHDTLTGKYRKVKNLYFDSKAEIERLQNTLAHQRISQSRTSLDDNEYANRFDRLDGAIKNVAFEIRQSWKTIPSWLGSVINSGAEVKGGREMTVVGRACISRWVVDEILEKFFHPALDVNLSAHLKMIEHGIRKNAPPPQSIEDDDALSAKVCNWRLTTLDGLRDNIHGPHAMEYRQRLSEHLVKQLVDSLQMHLHDPSPPGLLGGIQMIVDITVGLGANLPLESRDVRVWYPLPGERFDSKFMRGEVGLPPLVTPTRGPEGEGEKLQLDTNQQSHIMESGETSPLPPPAPAKDDKPLPAGKAGIGALPPPSGATQNKEGSGKKLAGFNNRFKKALQGSTHQPTSPNLSSSSTGQQGPQGQQQNGNSGSQAPLAQQQQPQPAQDPAAPKDGDRVRLAGFMACEVRGKLILVKAPVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUS8</accession>
    <name>A0A2T6ZUS8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUS8"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="10436" checksum="4C2238A4CD8E9F3B" modified="2018-07-18" version="1">MYNLTTNAKKSRESTNLSIHTPTKPNGFRDAGWRCLEDYRSAGSIVEKYMQEYGRLDTLGNNASKRTQYKGLAETDLDIVSSTFNPNTLPTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV72</accession>
    <name>A0A2T6ZV72_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">B9Z19DRAFT_1081871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV72"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV72"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="386" mass="43353" checksum="B1460D90FCE7CCDD" modified="2018-07-18" version="1">MRLKKVTSLPPQAERVWQVAIHPTLPLIATASSDKTARIISLQTYDPLSTIEGGHKRSIRSVAWKPGLTGESVLCTGSFDATIGIWRRYEHDLDVRNSQEGDEEEEEWRFALVLDGHESEVKSVAWSAGGNFLATCSRDKTVWIWEEIDEDNFETLEVMQEHTQDVKCVAWHPEEVLLASSSYDNTIRLYREGSEDWVCCSLLEGHTATVWTIEFEKPTSPGYREEWGARLASCSDDLSIKVWTRISRSGSAAEAKKAPPSILRGESIEENWVETSTLPQVHTRAIYKVSWSSKSGRIVSCASDGRIVVYEEIASVDTEMAERDEKKPPMTGWKVVAEIEGAHGVFEVNCVQWSKRWDKDAKGENDEVIVSCGDDGVVSVWELEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVP1</accession>
    <name>A0A2T6ZVP1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1081473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVP1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015588566" description="Hydrophobin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="8954" checksum="1A8BEA50F58BBA58" modified="2018-07-18" version="1">MKTLKCLLLLFPFVAIARSTSSGAGAPVPVCHDTGIVDYTLSLSLSPTTAPERRSKELPTNRTTDGELFRRVVGGIAVAVLVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW30</accession>
    <name>A0A2T6ZW30_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1081270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW30"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="18201" checksum="BDA84529129A3631" modified="2018-07-18" version="1">MIQRPTAIELNPYKKDTGRNSSFIESIRFTSKTPFSPFNLSRFPPPRPMTPEHSTVPYSTPPIIIIIIIHSASTQVLTQHRYRTVYHTSSRYRTNESEKRKKTPTPFSIIGKRKLYFTCDADFFVPTGLKKYCEGTRKQYGRVGRSGRKEKRKLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW43</accession>
    <name>A0A2T6ZW43_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1081056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW43"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015568562" evidence="2">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="101" mass="10973" checksum="736A29105589DCA0" modified="2018-07-18" version="1">MQFKSTTILPTPATLLPLLIATNTTSTSYPMLTNQLLKKSDQVWTPKPGTPRCNSDSTTPSRRIATRISNGALIRFNPISINVAATGALLVNSNFMNDPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWB0</accession>
    <name>A0A2T6ZWB0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_978108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWB0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWB0"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="435" mass="48456" checksum="7E5C6C70DAB35AF5" modified="2018-07-18" version="1">MAEDGRFYRLQSQDKMKVIRELALVQAELSKPSEFTNIGSIYHRGKDKSEFYVGELISAACGEDFPEEDEGAVPSKGPYSSLPELWQARLERETLLAIRNWSSLSSDPSTTSLSPPSKTDPQQFGEVMQLLSGLTSLFTPPQELATLCIHHSDLAIRNVLFDEKTLKITGVIDWEFAAVVPLVITGRFPNDLGWEGNEFARSLGKLGTAAEQWNHHYYDWTSLEGVTPPPAPNGTIPESPLSTTPDSPGDYLSAPNTSPPTPSSPDEKYLLCSKHPEEPQIPTTPTPHQSSEIPSPPSPPLPPPPTSQTSQKDLDIRAARLVQLFYLRKYYASCVASRDFALTRLFIDSIAYVKFNEIVMGGHDKWFSAIEWIREVFWRLKALGEDEAELGERLRSGRAVVTVPEVFGARADRGVVDLGGWEERMRRKRGVVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWU2</accession>
    <name>A0A2T6ZWU2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1124376</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWU2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWU2"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000010">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU79952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="136" mass="15477" checksum="C78F7EDE03D22DE9" modified="2018-07-18" version="1">MARTKQTARKSTGGKAPRKQFSHKVARKSAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVEAYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWY2</accession>
    <name>A0A2T6ZWY2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWY2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015595269" evidence="1">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="104" mass="11883" checksum="4A8929C1A3BB8705" modified="2018-07-18" version="1">MCLIFLPLLFPLHTSSWVFLQFASGVNVGVVCLNCRLIYFFRFLFGKANTGIGIIDRYTKEGGLRACLAERKEKYDALFKPSTIFKLCCAIREIVLPYETYIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX46</accession>
    <name>A0A2T6ZX46_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1100486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX46"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="198"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="806" mass="90471" checksum="1CA86B2C68462ACF" modified="2018-07-18" version="1">MYNSAKAGFGALATTGAAVAFYQTQIRRRILDERATLGNTAVGNSGTQKKDGNETWKENTETNESDNKAKKGIFSAMQGTLGQLVAEEASKKDLRPTPEDDLRKKGTGIVQAYEEGRLNQRDASTDTQWLTFSDKLLAAKESILSIDWPKLTNLTSVFPDWATGLPEWITKLQRELNMEPGSLADEVWSEARDPKVNPEVERDARVRLGKGLCEGEQRYLASRKGFTKRGLAQYLNIPEPEIHDDDVPIIATTGSGGGLRAMVAGTGYYQALTEAGLYDCTTYTAGVSGSCWLQALYLTSLGECSFDRVMEHLKARINVHIAYPPKALELVTSAPTNKYLLRGVVERLKTGYSSFGLVDLLLVPSNELTLDDNDLKLSAQRRFLENGEQPLPLYTAVRHEIPFIGGENEKGEPISEELKEKASKQHESWFQWFEATPYELYCEELEAGIPTWAMGRRFENGVNVSREVPEMKLPLLLGIFGSAFCATLSHYYHEIRPFVTSVSLFLSLDKMVLDRNNDLSKVHPINPCSIPNFVKGLKESLPSTCPVLCFHAIANPTQDAGMSNNLACYPLLRPGRNIDILIAFDSSAEIQTANWIGYAEGYAKQRKIQGWPVAIGWPNSDNKQSQQELEDAQAHSAKEAQQKLEEAQREASEVENEKPLSQRKEEQRKKNALGYCTVWVGSKEERDSKDEPPPSKAVEDDWELMKPNAGITVVYFPLIPNEKVPGVDPEISPYLSTWSFEWTPEQIDQTVALAKANFQEGAEKLKRTVRAVYERKKKLRLEMEEKKEEERHEENRRTHGIHDHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX49</accession>
    <name>A0A2T6ZX49_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1080205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX49"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6529" checksum="7F91B8B67BE886AD" modified="2018-07-18" version="1">MPNSLLRPFLPSSHREITNPVSPHCPFTFRSFTCKTGRPYARPRESAVLYSSYSVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX75</accession>
    <name>A0A2T6ZX75_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1100420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX75"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX75"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054080">
        <property type="entry name" value="TPR1-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21889">
        <property type="entry name" value="TPR1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="13">
        <location>
            <begin position="104"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="318"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="529"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="14">
        <location>
            <begin position="568"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="11">
        <location>
            <begin position="568"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="11">
        <location>
            <begin position="675"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="14">
        <location>
            <begin position="675"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU80107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="813" mass="89470" checksum="2B2BA51B04DD03F4" modified="2018-07-18" version="1">MRIENNGLNSQASVADSGRSGANGASAAAVETNGNGAGIRNGSGKLEGGSTASSFTMLAPPTPKPSYFGHDREEITRIVIQSLVDLGYHKAAGVLEEESEYTLESPEVSEFRDAVLQGQWNKAEELLFGLEINKDADVNALLFYMRQQKFLELLEVADVSKALHVLRTELTPLNQSVEKLHSLSSLMMCISADDLKARAEWDGAAGLSRQQLLSELSKSISASVMIPEHRLASLLDQVKKNQLSKCLYHNTANSPSLYTDHHCDRNQFPLSTVEILTDHKDEVWFVQFSNDGARLATGSKDHTVIIWDLEDFRPIHHLKEHTGAITYLRWSPDDSKLLSCSQDKHAKLWDTTTGGCIRTMNAHTDWVSSCAWAPDGLTFVTGSVDKEMILWNLLGENIHTWTGARVYDLVVTADGTRLAAVCTQHKLHVFNFVTREKEYERDLGGVSTCISVSKDSRYILLNMGAGVQELRLLNIETGADVRHFSGTKQEEFVVRNCFGGADENFVVSGSEDSNVYVWRKENGALVEVLPGHSGIVNCVAWNPTNPYMFASAGDDRNVRIWSKAPQPQLKGKMKGVADSFTISSITHSEATQTTTLTITDATPILTDAHLGDSISVSGTCLTITSFTKDTFTVDLSPETLRRTTFPQSLPPSSSSPVQVNLERAVSGDVRFGGHFVQGHVDTIAGIIDRRPDGSSVVLRFRPRDREVMKYVVEKGYVTIDGASLTVIAVGGGSEEGEGQGWWWEVMLVEYTQEKIITARKQVGEEVNVEVDITGKYIEKQVLAYLGAGDGETRGGLLERIVERVVERKLAERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX85</accession>
    <name>A0A2T6ZX85_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX85"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX85"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="413" mass="45890" checksum="93E7D538B7AABB33" modified="2018-07-18" version="1">MHPRSIYREFVDFGRLARDCPSLARYLDTSSNINFKDPDAVRELTKCLLYRDFGLNLVLPGDRLCPTVPNRLNYVLWIQDLLDSTGNLENDEFEPTREVVGLDVGTGASCIYPLLGCALRDNWKFVATGLHNIERNREKVGGLDERITVFDNSPDDDIFPVEKLGIEKHYHPIHDMFDSARKKNLPPSSACTGTTTEMVYPGGEASFITLMLDQSLQLRSNPDFKNTWYTSMLGKHSSVESLVPVIKLHTQNYAITEFKQGSTRRWGVAWNFGDRRPCLAAVRYESSQLRGLMPFPTEFEFDAAGDVMSVGGVIDDTLAAEIGLGSGEWVWDPSVSAGWGGVRGNVWSRAARRAKARGLEIEGIGCGVALGFRVGVTEKGGQSVKVKIRWTRGVDSVLFESLCGMIKRKILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXB3</accession>
    <name>A0A2T6ZXB3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial outer membrane translocase complex, subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1080090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXB3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXB3"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU80129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="142" mass="15894" checksum="414991D923EB3721" modified="2018-07-18" version="1">MVELREVEDEHFVNAQPAPSDDEDYTDTDSEISEEDEDDDADLEESLYERIVALKDMIPLKQRTYISNGFSRTYSLFTKGFTLGGKTLWILSTSALVLGVPFAVAITDEQQAAEIDKEFRMNQITTDALTPGAESIHTAPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYB6</accession>
    <name>A0A2T6ZYB6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1044706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYB6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYB6"/>
    <dbReference type="OrthoDB" id="29773at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012404">
        <property type="entry name" value="UCP036436"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13146:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036436">
        <property type="entry name" value="UCP036436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015514642" description="Integral membrane protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="47257" checksum="1B3F639CF2017860" modified="2018-07-18" version="1">MPRRAVMAVLITGMLVTGVANTLLTKYQDMQCVRNCDDPDISKRHVFEQPVMQTLQMFIGEMGCWLFVGLFSIRQCIRNRQRKSAGYEPVSAGDDATAGPADGTSSPSPVVKPSVTSLDDRVSISGFSVFLLAIPACCDIAGTTLMNVGLLFVAASIYQMTRGALVLFVGLFSVLFLKRHIRGFQWFALLLVVIGVGVVGLAGVLWKEEQPVKGSHILVTSTPDVPIAVKTIIGVLLIAGAQIFTATQFVVEEYILEHYELEPLKVVGWEGIFGFLVTVIGMGILHYTIGQTPKGQFGYFDAVEGFREITQYREVAISSLAIMISIGGFNFFGISVTRSISATARSIIDTCRTLFIWMVSLALHWESFKWLQIVGFALLVYGTFLFNELIPPPFIFCLATRYNRRELRREQQERERARQALLPGATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYM1</accession>
    <name>A0A2T6ZYM1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1171200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYM1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="20332" checksum="07708E4EA5F1F7F3" modified="2018-07-18" version="1">MTEPPVLCSFEYTGIRLPQCTTSPPAYTASLAAAPNSQSSKGGPYTWGRRKIQLWSEKSLDIPRTLANSMPLIIFKGLIGSKALLFVIPFDFKLLLAHFSNALSHVPDFCDPSNLVFAEWMIVDDFQLGAEVRRCDGSMNIVLQYWQVTAKIPSYLVFVDKELWFLPPYYDLMFGGALKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ84</accession>
    <name>A0A2T6ZZ84_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_973832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ84"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ84"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="558" mass="61282" checksum="5C335143D957B1CB" modified="2018-07-18" version="1">MTNEGVGPLLPPSYGQLQQFEPQVGRGLPGPLEIFRIPSEDPYPSLFPSKRRESPPLSRRNSVIQQQRPREEQPTRRRRGSTSNAGASLTVPSTVNGSKANLAEFASQITCLLWFESSAMLQRIAEPTTTLIPQAPLASDATPSLGFRKWVTTILSTTQVSQNVILLALLFIYRLKKLNPTVKGKPGSEFRLLTVALMLGNKFLDDNTYTNKTWAEVSGIAVQEIHVMEVEFLSNMRYSLFVGDVEWRAWHKTLGKFAAYWEKASRAPVEVSSRAPAPLTPTLPSIPGSLPSPPTASSSPNGSSRLVSTMPTPMPALHHQLSVPSQLMPAHSPITPMPQPDFQPSRKRSFDPAIGMQPPTKRITRSMAPKISITVPQYSAHIPAHAPRLPANNYPPVTSQPQQQSQSLPMMPLNQLPFPNAGGRAMSTVYSQPTPQISPVSTAPMTVSPYSAHSCAASPFSQHQTIHHSAASSPTTPGFGSQQSPTWVRNSPYRPVRRVNTLLVPPAPMSPEGMGVSWQRMHYQPLAKTRTEYKTGVVPYLQTDWPPVWSSPAPDFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZJ8</accession>
    <name>A0A2T6ZZJ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZJ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZJ8"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="146"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="560" mass="62298" checksum="D3736A85924387BF" modified="2018-07-18" version="1">MSTARPGNTGTYHPEHGTPHTHKRKKLILCFDGTGNKFKGNDGDTNILKIFRMLDRSGSDHTSFDQHVVGGYKFLMRFYAPGDDIYMFGFSRGAYTARFLAEMLDHVGLVSQGNEEMRRDGEGWGARKQDMYNYMRAFRETFARPRSGFPYTARSTARVIRHAVGIDERRAKFRQDLVEKVDMQEMARHRTFKAERLVKSALGHRPASKSKPNKNDGKSGHPYQNGNSANAGPIPQRFSGSREALSITTNGGDSGSLMSLNIHVETDSEDEDEKAEQDIEEVWFPGAHGDIGGGWDLPDGEEPLSHGPLVWMVREARKAGVVFDKLRMKQMNVWLDEFETDELDPKAPETPISPVVGDDRIPAIEVSGSPSRDSPIQSLQQQQQRSANLTPTPTNGTHPGSHTPAHASTSAPTSTRATDPETYLLNSYTRGRIHDCLCYPSGGLSMSGTLGWKLMEYLPFRRMDLQPDGSWKPIIWPLPCGEVRDIPDTVRIHNSVIRRMKADPKYRPGNLIVGGGGRGVRRAPKSAGIGEWEVLREEGSLVGEVFVKRVAVEKGLVEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZW1</accession>
    <name>A0A2T6ZZW1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1062971</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZW1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZW1"/>
    <dbReference type="OrthoDB" id="275177at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="215" mass="24298" checksum="1E60F90E584281FF" modified="2018-07-18" version="1">MLSYTYSEKSGVHVSTPSAIHTMGKVQSIPKHETRLRHIWIITGPAGCGKSSVADFLAKRLNLPYIEGDEFHPRSNVEKMANGIPLTDDDRWDWLETLRNKAVEALESGAEGCVVTCSCLKRRYRDVIRIAGREADDVIVRFVYLRASEELLLKRVKARKNHYMKDDMVHSQFTALEEPDESEMDVISVDVSGNLASVQNLATERVRGCMEEESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZZ1</accession>
    <name>A0A2T6ZZZ1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_972688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000051">
        <property type="protein sequence ID" value="PUU81068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZZ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZZ1"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="5">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="21933" checksum="C2A0CD67976FF15F" modified="2018-07-18" version="1" fragment="single">LRFTGGRICDKLRSIRRLDICLRVKNMSWGNFAAQFSEPIPKNMEKCSLEPHSVSKMKINAEKSKHLETATTNILDIGFVILRSVRYPENSRTWNSRTPEKDTLHRDFPVNALFFNLPTELVQEFTVFGLQEIAAHIIRTQTRTKETSTSPSSTGKAQCVTKTISAIPWWESRDRQRCCKGFICGGRIRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0A3</accession>
    <name>A0A2T7A0A3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0A3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="9723" checksum="13F18F99C29C95C2" modified="2018-07-18" version="1">MSSHSHEDTSERSMSATAPSSKVEGDKAEKEEKPRVNELELRAKSMEAVEVSVADRMAILEGMLAARKNGDNIKYDAGILLDAVARAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0J0</accession>
    <name>A0A2T7A0J0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1099873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0J0"/>
    <dbReference type="STRING" id="42251.A0A2T7A0J0"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="140"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="356" mass="37684" checksum="781E91E4C8437A40" modified="2018-07-18" version="1">MGASAKRKREKQKDFRKPKLKVGKAKAKADNFTNTSFKSKAITLAAQSLHTTAPSPTYLFTHHLSLLTHHSATTRKESLSYLKTHLPAALSITTPTTPNAISNLPTTSSLISSLLPLILDPSASVRAQLLTLLAHLPHTHLVLHTRKILLFINSAMTHISSDIRADSTKFLDWLLRASGEEVFSAGGWGVCLRGLCGCLGFGGATGGSGGSSVIVPKVQDGRVALPHLAVLAKVLEVGLAKPVGGEGEVGMGDKRRPDGLHVSYEAHKLPSRSNVYVSLGLFDTLGSVSKEGVLREAEPEDRDSRIRYLIGGAGRGVFDSLTLGLGRLKKGGGEMGRAAGKVLVALEAADREGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1J0</accession>
    <name>A0A2T7A1J0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1J0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="12571" checksum="F81F59634A5B4AF4" modified="2018-07-18" version="1">MGTSCGFSQPDTVVYCTVGSITFSEGSLRQTFREFLGAGSRGGSSHLGGLGTKCGSESAILRSPENIADASDTNDGRGREYCPKINKIGKPTKNVTRLMGPADDVESLVDLKDSPPWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1K4</accession>
    <name>A0A2T7A1K4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_590730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1K4"/>
    <dbReference type="STRING" id="42251.A0A2T7A1K4"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="415" mass="45813" checksum="4ABC7D4F34704E0B" modified="2018-07-18" version="1">MPPQRTLPPAKAVKTERTHEENQERAYIAASRRSDRSLEARIESARRASAIHKRRTGRALRVTEQDVINEEMYEEEEDEYYGYRGLAASFRNGSHDLNRRLQAYLQSQLVMRSALSQAMSVDGGNPSQQYPAIQSTYQSSYMQQPMGGPYVDASVHPPHMSPTTYQSLRQQPYPSPAAGQQRYQRAMSMQMSQSPSMHPQGYQQGIAYGNQPVFAPSSTPAGSLGTLAGQYPTQIMPNHQTGMMPQQFTPQQVASQASKTNTSLSFNDSLAAFPFTTALPPETQQFLQPALDPSDPLYPALMAGHSNAPLFGFNNGANDLKSPITESTPSVRSSEINPSPPSFSPLSSDQTTLDCSSDQQTLNSLFDPSAVQTSSPLEQTSISPGGDSISNENMFNSWNDLIEEDNIWNHHLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1M5</accession>
    <name>A0A2T7A1M5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_581181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1M5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="167" mass="19342" checksum="5B665C50E3D6511D" modified="2018-07-18" version="1">MRCEYRTYLHQGSWTVTESRENLRNLTKLSNSKITTRQKKNKKKYPIIPVVGSSIIPVSYLREPSVVILSRKPKAGTPITITTTTATQPNFHFTPFPSFSPSPLAPLLEYKHTSKQKKKIQFCKRIRHVSTTSQPKHKSDRSTFPQQVTPARICIFFPSFWLCMMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Z3</accession>
    <name>A0A2T7A1Z3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1099573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Z3"/>
    <dbReference type="STRING" id="42251.A0A2T7A1Z3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015712868" evidence="3">
        <location>
            <begin position="25"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="863" mass="95214" checksum="35625690B5B5C337" modified="2018-07-18" version="1">MGSTMSTLLASSAIFLALPPGALATNGVDFSNNLFSDLGPILALFGEQVTKQFMSQSMSWLEDVIFAMAPLGIITAIISAVRVSRLNWLKAVVGRARESRAVAEMELMSSTSHEVCELWNGQAIVRVMGSPDIVEILYFKDIADGNGKCRSFTFEMAVEEGLLEKTKETGKGGSTRAKENLPMTATNGDAPGKKKGVFSRIFSRTSSNSLSANRGPARTDVENGPISLRSNSPQNALRPTPGHTTRDSAPNISLNIDEIKGQRELWLFAILGSVLQLGSLVFIGVTHYHPKINLKEGENSGYAYPLMASGTLFLVMGMMACSHVVQASSVETTWKAKKPFRILWLQKSGTVNDQRFGSYVLFAGKERNTLTTSLPRTYPPSSKHPSSTKSTFAVALSSWNLTIAGSFISLAGFVTQFVGIRALHWSASITQLAVTLAMTAIRTWIRRNLSAQPKAIVLHPGYDIDRLAVRSAMSVEWLLESHEHGIPEHDDDDGSDYDLGLEVLTLQPYCGYEATEEVHTDMTDAIRILKMRVELGRLTDQEGLSYPFALELVKCLQSLLSCFVTSQSITLKNDFANSTAFRWALPVKVGEEIERITITARRSQHKSGNWLSWNVPISEICAIISLWSYRMKKYEQALGNTVDGDRSFLGRGHGAPVVLRVLGPATDLLIRDREWWMDRGGRFVVVRNWELENAKSSSKVTTLETKELSKTIGQANRSTAKNSTASVAPHRIVGTEPIYHESLVFVSETPFRQMCAQEILSSFMWAIAGTVQFIVGETKPQSGTPPWDCESEPDEWFDFKLENDFFQKLAETIAKYRVISNIQDAYALIIPPFAKADKLPGVSGETGECCQDKRSLPGALQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2C6</accession>
    <name>A0A2T7A2C6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_970179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2C6"/>
    <dbReference type="OrthoDB" id="5397778at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="225" mass="24639" checksum="CA828CA042173094" modified="2018-07-18" version="1" fragment="single">IDGVAARRKPVPKLRENPDAPPTSPPVSKISTSGAGKKSLQYTGPVGPWFPTPLASADGAKSSPPLPPTELPGLAATKPNTYCISDDITRRPSVARGYRFNEEHEVQCLGDDIQNGSLLAGEKGILPSEFFDRHQTACISDDLARVYLGLGEEGEQELQSQMEQEQRLREARREMVCLGDELSEWHIDRSGLIPVMEEDEGEAPTHAQPYTAEIPIAVEEKDARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3V1</accession>
    <name>A0A2T7A3V1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Geminivirus AL1 replication-associated protein central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1061899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3V1"/>
    <dbReference type="OrthoDB" id="5242237at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016888">
        <property type="term" value="F:DNA endonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022692">
        <property type="entry name" value="Gemini_AL1_REP_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08283">
        <property type="entry name" value="Gemini_AL1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Geminivirus AL1 replication-associated protein central" evidence="2">
        <location>
            <begin position="233"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="431" mass="48772" checksum="E922174AF808E763" modified="2018-07-18" version="1">MLFDNLTQIMNEHFENNVALSSLPSSPPLSPKPSTPNNSASSSSISEESTEVDTPIIERDPSPIPTPAQWRRVKEVQEAAKVLTDISHPTKASSIGPPPRNPQRVPGWWQHLTLNQTLDPYLAAESVRNTLWSHTPVVTASRLTRLWTYLDAITSNLYSDQSAIQMEDFITTLSAVEWAEGDSSPVTCDASTFNSAYDYAGKDGNVLVADFERGDIEREGTSGEGKVALLECFNASTKDQFLENVRNVAPRLYIGSYNNLRLVAENHFPDEDVTYSSPYPVDSWRINEEISNWYNTFLSLYSDDNCKGIVGLRPLSLILYGPTRTGKTEWARSLGNHIFFSGFFNLSLYRKIYKYIVFDDVEFSRMDIFKCWFGSQAEFTTTDKYCRKTNIIHGRPVIGCFNQDPRLANWADIEWMDGNCIFVHVTEKLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Y3</accession>
    <name>A0A2T7A3Y3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1112878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Y3"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Y3"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="26358" checksum="C195778D1CB4B915" modified="2018-07-18" version="1">MLFKAMSASVAGFDTDNDGDGEQQQQQQPRETLLQEEERVSLDTFPDEIILAVCELGCARIGGFGKAHRLYTLSTNPLLRKVRLHRAKAILATSLKLRFSYAQCALSRVLLRIRLKYHFFTWLSLPALLERGVVYRCGEIALALAGKARHRERELRRLSPEKTVECGLVLNGVGWGEGRREGARSTAKRLMAIERMDRYDPPRAIIWGLKRYFEKLVTKGGNRPPRHTVLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A434</accession>
    <name>A0A2T7A434_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1120539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A434"/>
    <dbReference type="STRING" id="42251.A0A2T7A434"/>
    <dbReference type="OrthoDB" id="5238363at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="194" mass="20850" checksum="80E5A2F9986BF5B6" modified="2018-07-18" version="1">MSVFHATKNFILRQSLKPQALVNSRILANPMHPLHAQIYAKFHDPTLKDKLVINFTASKNVSKKAVVRNRARRRTREAVYQALRERGYGKEGEPLAGGGREKGVTGSLSWFPTFESVNAASEELRAEVRVAVDRWLEFRERALAGGGGKGEKKKGGGGEGGGGGGQGKGKGKGKGKEQGKGATLGKEGPETKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A451</accession>
    <name>A0A2T7A451_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1099096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A451"/>
    <dbReference type="STRING" id="42251.A0A2T7A451"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="26278" checksum="0B6D146AF2516800" modified="2018-07-18" version="1">MCPYVSRSSFQSYSHQMLVDRQVPGYIKGKLVAGFVRRFWQSSEDHRGTPEAPGRVVTLIERSYWETLNDHDFEDDDQVWGMAYRIKADRVEDVMRELNIREINGYSIRNDIEVFSSEPEAPTIRALVYIGTPENPQFIAREGIPGLDELAHHIFNSRGPSGENRDYLYNLHKSLVGLSPAAHDHHVSRLFHRAVAIEAENKIKHLGEHEAVGPGTADRRSKDKQEEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4S9</accession>
    <name>A0A2T7A4S9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4S9"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="448" mass="51945" checksum="3FABFBEB29F33A18" modified="2018-07-18" version="1">MSTPNGPLQEFFSQFNFQRYTYNPHKPPLEEFERLCQERQWGPSKIRKHKAAFLLVFEREQDPRGGLAASNVLLQEFFSQFNFQGYTHDSHKPPLEEFKRLCQARKWGPSKIRKHETAFLHAIGSEQDLRGGLAGPNVIEFFRKYEYQRFTYDLDAPIQSEFQRLVGLRGWGKANLSKVTRRFNRAVALDAREQSVYSASESTDPEGPGMQEVDLLADWLKKQECRGYRYQGGLPELEFKKLVDVKRKEWKQAHRELEHCLSWKHSLEFESLRIKFYGVVEKVFNILLDRFCQITGFTPWQVLVGLYGEGQESVGKNAAKTILKKVFVNIFDFLDAFQEILKNPPTTDRQELLRLLKPRAIEVQFPNKMMLGVYSALTNRVFPVSVAKADGTLALLLNFIKRVLKGFGGVMRRFKKEAGDELRAAKKEGRVAIRSLLLSREWDSLSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4T4</accession>
    <name>A0A2T7A4T4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1074379</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4T4"/>
    <dbReference type="STRING" id="42251.A0A2T7A4T4"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="421"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="61"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="594"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="618" mass="68309" checksum="E4D64BEF2A8AC576" modified="2018-07-18" version="1">MASPRGSPLSAVFLNSPTHGGLPLSLHEINEDQPDGGAYSVISSRMTDVSDNGSDIMGLAEAQLSQNASSPRSSLQPGLGRANTRVSISDPQPDAFSTRPSTAMSTSTAAARGWSNPPPSRRGLSSVGGGSQRGRPSSSASRTHAPSLTSHAFYRPMSSTKLQAQRGKVTEEDEVEQNRIRGFAQAALGVSDRSPVLGLSMHEPIIHQHRVSDDRAQYIQSGSGSPTGRTMHTAQSITSVSPLNTSAESSLNNRQSVGNDHRVVMNGSNGNQLPKLDNSSRGSSVAKPKQQPQSSKEKNWQYFPGKTAFCLGGRFQTARDAPMNLLTAVLVTLPACLFCVYSAKWLWKHVSPALPVTFGYLYLLCMMSFLKASVSDPGVYPRNVHPLETDDTDDALAVPPPNGWALIKPLKPSQVHLEVPIKYCRTCRIWRPPRCHHCRVCDNCIETQDHHCVWLNNCVGRRNYRYFFAFVSTATLLAFYLLALSLVHLNEWKKQTNHSFSDAIKEWQVPFGMVIYGALAAPYPLALLGYHIFLMARGETTREYLHGHKFVRSERHRPFAQINAFYNLIVVLCRPRPPTYVELKSNYQIGDQRFERHQPPQLSSNGDEAGEEQTNRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A519</accession>
    <name>A0A2T7A519_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1190116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A519"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="20548" checksum="F65D841558BCD8C2" modified="2018-07-18" version="1">MVHSLSGPTSKTLLGTLVTEFRCPQQSPNRGIARLFSEIFATDEEASKFRNLLKSSDLSPSQNSSDLSSVLAIPFTTFAVLAVFFLDGTSQIIATFFDFVLFIGYVTSAVTAHSINGHEDRNGELVRLVVGLVVLQLILFFITTILSLLVVRRSEASDNSPVSEKHSRFSFSRSSRGSGENRAVPSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A588</accession>
    <name>A0A2T7A588_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RmlC-like cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A588"/>
    <dbReference type="OrthoDB" id="5329412at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015650995" description="RmlC-like cupin domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24503" checksum="400F758A19E61E96" modified="2018-07-18" version="1">MRLSSLFLLLPTFTLGSYGPVRLGSEDYNNTEMGITRWHLCPEPSSSDALVIPAVVSSEIESNPDGTKLALFQCWEFKYAVPSVPGLETASLIPWGDFAKSFQFDIKGAYHQSPHAPPAVSLIVFTAGEGVIPPLTRFNIPISFPLCFCACIRGLVVCADIDVSEGVMTIPGTGQKWRGRGGDILIAADTDGSHEMDWKAGTRVVDFFFSGLDAIPEHKVVPAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5W5</accession>
    <name>A0A2T7A5W5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5W5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="10911" checksum="62832792344481CD" modified="2018-07-18" version="1" fragment="single">MRKLVHYLIKQRGSVFSGQLVLSSFCSLLRRGAVALVLLPNAVSLPGKPSICVFHVQPKSRARHQGPQRRIEQCAEFLPGRRVEGRRRFIEDFKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A641</accession>
    <name>A0A2T7A641_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1119768</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A641"/>
    <dbReference type="STRING" id="42251.A0A2T7A641"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="557"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU83145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="690" mass="78125" checksum="7F7DAA25F712E965" modified="2018-07-18" version="1">MIELTVLLTEFPDIRIDYFRRSNDPGARPPLACFLTHIHSDHLQGLEGFYGGPFIHCSAATKELLIKLERRLHRFNLAKGVLEARQCLYAEKEKKLKVIPLETPTMVEIGSGKSLRVTLFDANHCPGAVMFLIEGDGKAILYTGDIRAEKWWVDNLRRHPVLVPYVMGLKTLDKIYLDTSFAGRSRIHEVFCSKKDGIHELLSQVQKYPQDTIFHLNTWTFGYEEVWVALASANYHRRLFHFIRSPDKYVHGPFLSGFEFGNSKVLGCTTSNIEARFHSCEKRVGCEGLEGKRNVVWIKPVITRVGSFDVHEAGLGNGDLESQDDLELRDEHLKQILEVMGPEVSESVRDLLKEARTSMKQVLPLSLQKGTERDDLTAPKLLGLLSEAASISSQRKSQETDSQILIPAPASSDGEGIVAGNGEILPNAITFPFSRHSSYSELRSLVSAFRPRDIYPCVVNEATWDEEKSVKALFGDLCTGDEFVHDNDMRQRLREEHMAQEQLEEERLERELESQRNLARSQLEQIEINFRQHQPEEMATEGSKDTEDHWWTQARAMASSTASNTPATSPVTAPKTPKRLPDVALVTPVMSSPPGSPTPKQIKREPHASPPSPPTWPAKRIKTENPLHETPLNPRSPGKRARMSSVEREFADDERFWEGVEAALEVEGTWWDVGLSCTMQKWRYEEEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6N2</accession>
    <name>A0A2T7A6N2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_964377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6N2"/>
    <dbReference type="STRING" id="42251.A0A2T7A6N2"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="2"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="207" mass="22485" checksum="D9E2F039E04D6222" modified="2018-07-18" version="1">MRRSTPLSYAVRYGHEGIVKILLGRGDINSDFSDKYNRTPLSLAAEYGHEGIVKILLERGDVNSDSLDNDGRTPLEHAQKSSKLGVVKLLSEPKPLSHKTPPTRGMNPKIPGSALSAQVEASDLLPQQDCIIPTIRRDIIEVIPLSPSDESPLNQHGVDSSAPILTSAATFDTTPVSTILNPSRPPKRDRVTPPPFPPAKRPRLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6U0</accession>
    <name>A0A2T7A6U0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6U0"/>
    <dbReference type="OrthoDB" id="5428368at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="254" mass="27486" checksum="7870984E72CD8C14" modified="2018-07-18" version="1">MALRNENTTTTLRRSTTLEIRPSPSSLSSTYGPFTSPTSPNTIITQAPSPYSATNSPSFSSSSPPSSNEAQWSISASPYPPPSGYPSYPVEGKLLSIQTTGIRGRKSFGELAREIQKIVRPPRERARVRCGMEGRGAVKKKEGGNREFPCGSRKGASRGRIYARVIKKDAEKKGEKKVRKKEEKVVVDIEAGLKRTICSGQGGSMRGVACECDGWKLIPREGAGAGSAGLSGTKMVLCNRSVELLKQRYAEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7K8</accession>
    <name>A0A2T7A7K8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MoaB/Mog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1098546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7K8"/>
    <dbReference type="STRING" id="42251.A0A2T7A7K8"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="296" mass="32964" checksum="60692F959B8A38C1" modified="2018-07-18" version="1">MAASQTIRFNKPISTSACLIIGDEVLNGKVVDTNSGYFARFCFDLGVEMKRVEVIADDEGEIVEAVQRMSKNYDFVVTSGGIGPTHDDITYPSIAKAFNLPLTLHNETWTRMRKLSKSNKTNPSFDWETPSTMLTAKQRMALLPTGPNVRHVYISPDLWVPICIVDNVHILPGIPRMFEEFLEGLRPSLNVNSHNKQTRVLFSTPMKESEIAGFLTNLQEKVKQRGVKVGSYPRWGKTKNTVTLTGADKEYIEGLVDEVEKGVGGLRVSIEGEDDEQGKPEEIEKVEATTKGEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8P5</accession>
    <name>A0A2T7A8P5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1118421</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A8P5"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16702">
        <property type="entry name" value="RING_CH-C4HC3_MARCH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000287">
        <property type="entry name" value="RING finger membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="888"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1072"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1122"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1169"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1228"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1271"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1431"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1474"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1528"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1573"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1619"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1662"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="17">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="353"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="650"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="773"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="598"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU84111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1727" mass="189662" checksum="9DEB9868A82BCAD9" modified="2018-07-18" version="1">MASESGPQVDIMNDPAYNASSASGLNGNGEPDHCRICRSEGSREEPLFHPCKCSGSIKFVHQDCLLEWLQHSQKKHCELCKTPFHFTKLYDPLMPTTLPTPLFLDRLFRHLFRNLLLWARALLVGCVWLGGLPYCVRWMWRMWFWLSDGGWWTDQAYNRTGTASATATPLTSLPGTPTVSSAVMNSTSSAFGSGIMAFLRSPLLSGPVMSPINGGKVAANVTSAINATLSNGTITIRVRLGGLFIDPSPFHNFTRYPAVNGVIVDIFEGQLLTALIVISFILIFLIREWVVQQQPALGGAVVLPQLDELQVPQAENIQLPQINPPPPPPPPPQDRLAREHELARALEQFRGELPPAHNRVIANPRRRRPFPVAAPPADPRSDPGVDSAQDWPTDFSNPNTDIHTMQKYGQGHLLGGGGNSEPTGTDNRLGDLGESSNQSMRRPQVNRKAMSQPAEIRRAMEEKPEASDHGSQGPSTSTPYQFEFSFVGRGQTPSPLYTPESGNSSGSRTPARSGRAPSPAGYNRGIIDTGAPGGERPLYSFSGNGSPKITAVGESASSSPAEGQINKGKQPDPPFQAYENSIDNEDQWEDEEEEDDMVDSKGKGKEIKTSSAHADLSSYHESSAAGSLDFAMASRPDFAFKARSDPIRRAPTPVAARYPPPSISLPSTPTTSGSLLDHAGDESTRIGLGKDARQGCDEAGGVSDTGVQGVEHTFGNQSTDTPTMEYGAQNVEVEAIQGSPAPAQEPVPHQPPRPFDWWDRDAPEDMAREVAEEIAENDTGTEDGADDGTDAEDDGENEVGDGPAIELPPDALQAIADEDAADDFDGIMELIGMRGPLAGLLQNVAFSIVLITTTVALGVAFPYVMGKIVMIILANPIFFLIRVPTTVVSFVAEFAVEFSTCLLFSLLLVVEQVMRFLFRPIERAVPVFSGVSSSLFLSDILKRLALDGQDRITQKMTNLKSMYLDLRTFPSTGAPPVSALTRQGWLKASLGVNWTMEKLGFGTNQTYSLSFPQDKSVDTSTPVAFFNSSFTKAITALFRTQRNATNATTQDISPENLSSLNPVYIWSVWDRVTAVFIGYSLFTLIGMLYLQNARKRDLAVNGRVVEKIAVELLAQAGGVMKVVLIIGIEMLAFPLYCGLLLDFALLPLFEEATILSRIQFFADFPLTSVFVHWFVGTCYMFHFALFVSMCRKIMRSGVLYFIRDPDDPNFHPVKDVLDRPVMMQLRKIGFSALIYGVLVIVCLGGVVWSLHLATESVLPIHWSSNEPVLEFPVDLLFYNFFMPIAVQFVKPSDGLQKMYGWWFRRCARFLRLTSFMFGDRTADEEGHHVRQGWAAWLLRKNGDVNHPIIEADALKEAGGAGVEVYFQKDGGYVRAPASDSVRRPKGRRVFIPVTEDNVRLDEQEDPVDSANGPNSPDFKLVYLPPWFKTRIGLLVLAIWGFAAFTGVGVTIGPLLLGRTVLKQLVPPNIKLNDIYAFSVGIYIIGAFAYAGAKWKLARSLVRRGIRTARESESLWRAMGKWLVRVAKISYVLTAFGIVLPTLLALMIEFYVIIPIHTYFSNDKQHVIHFIQDWTLGVLYIKMMGRMLLVNRDSAWARSLRGVVARGYLDPDVKLATKHFIAPAGGFMLVALLLPLALGSIAANTFLKNAPAEKISQIYRYSYPAVFAIFFLIGLGYLWGILVASWKQSIIDEVYLTGEQLHNHGEDVPPTTAEAPATVAATIAVANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Q4</accession>
    <name>A0A2T7A8Q4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">3' exoribonuclease family, domain 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1014229</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Q4"/>
    <dbReference type="STRING" id="42251.A0A2T7A8Q4"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="36"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU84127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="336" mass="34966" checksum="B9E01A936DF552F9" modified="2018-07-18" version="1">MTDRRRINGPAEGTTPPVFLTSSTHKPVIKRSPTTLRKIFLKTSLTPPATGSAFLELPTPSNPSTPTLKLTASVYGPRPLPSSTTFSPDARLTAELKFSPFSTPGHRRGYIRDGVERDLSAQLSIALEKSVDVGKYPKSAIDVFVSVLDCEGGLGDAGDGNDGGVEVGLMGVVAGAISCASAAIADAGIECFDLVAGGVAGLIRERGGVVEEDHVGEGMEAGEDISGARHGEKKNRGIALVLDPSPTDGYIILAAAAVGYMAARDELTLVWTKGSMGREGDGTDEVERLVDGAIAAATSVRLVINEAVKERLLLGLKEIGLIKEKAGGNDGDIVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8X6</accession>
    <name>A0A2T7A8X6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1070797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8X6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="9039" checksum="84F1FA027DB460F4" modified="2018-07-18" version="1" fragment="single">MRSQSPFTTAFYAIPSVHRQKDVPIQAFPMALQSSLKVLRALSMRSQSPFTTAFYAIPSVHRQKDVPIQAFPMALQSSLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A913</accession>
    <name>A0A2T7A913_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_956522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A913"/>
    <dbReference type="STRING" id="42251.A0A2T7A913"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="9798" checksum="D49068E9F6BE8C6F" modified="2018-07-18" version="1" fragment="single">SLLTVPDHDGNTPLHEAAISGHSSMLKALVKKLARHKTYNTIINEQNRFGNTPLHLAFQFDHQEIVELLVKGGANATIKNNAQMTPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A953</accession>
    <name>A0A2T7A953_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chitin synthase</fullName>
            <ecNumber evidence="2 11">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_960894</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 11"/>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A953"/>
    <dbReference type="STRING" id="42251.A0A2T7A953"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="122"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU84259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="892" mass="101096" checksum="6D09165398C28A88" modified="2018-07-18" version="1">MAYQGPPPGGFQPEHHDLQEYPPAVQDDITDHERVPLTGGIQEGPGPFRGPFDENSSRTSTPDAFRQRSTSGPYYSEMASPNPSTPTLSAPSASGASRPSSVVSMDEWRRRQAPQGLRRYATRKVKLQHGQVLSIDYPVPSAVQNAIQTKYKAPDDDAAANEFTHMRYTAATCDPDDFTLKNGYDLRPRMYNRHTELLIAITYYNEDKVLTARTLHGVMQNVRDIVNLKKSEFWWKGGPAWQKIVVCLVFDGIDPCDKNTLDVLATVGVFQDGVMKKDVDGKETTAHIFEYTTQLSVTSHQHLVRPTDDMDNSAFPPVQVMFCLKQRNSKKINSHRWLFNAFGRILNPEVCVLIDAGTKPGPKSILALWEAFYNDKNLGGACGEIHAMLGKGGRNLLNPLVAAQNFEYKISNILDKPLESAFGYVSVLPGAFSAYRFRAIMGRPLEQYFHGDHTLSSRFGKKGIDGMNIFKKNMFLAEDRILCFELVAKAGSKWHLTYVRTSKGETDVPEGAAEFISQRRRWLNGSFAAGIYSLMHFGRMYSSSHSIIRMFFFHVQLIYNVFSTFMSWFSIASFWLTTSVIMDLVGDPSDEDKKRGKHAWPFGDTVTPIFNNMLKYIYLAFLLLQFILALGNRPKGSRHTYLLSFYVFSVLQFYVLLLAFYLVVRAFTNQESWSDLKANTVGEFIKQFFTSNTGLIILALASTYGIYIIASIMYLDPWHMVHSFFQYILMASSYTNILNVYAFCNWHDVSWGTKGSDKAEALPSAKTKVEGKSKVIDEPEKPQADIDLAFEETVKRALSPFVVTEEVEKKSLDDSYKSFRTRLITFWIFSNCTVVILFTSANFDWFGVDSTKRTAWFFRFVLLATAALSFFRFVGCVWFLGRASILCCFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9J6</accession>
    <name>A0A2T7A9J6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1070263</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9J6"/>
    <dbReference type="STRING" id="42251.A0A2T7A9J6"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="10">
        <location>
            <begin position="72"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="11">
        <location>
            <begin position="597"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU84407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="799" mass="85580" checksum="CA7F5722FB5E652E" modified="2018-07-18" version="1">MLSTRLARAGSCKIKSLSYSQLLRRSFATPATNSNFSVHPEIATRTPPYGKLTKNLTEVRRVLGTQGLTLAEKILYSHLDNVEDALGGRNGKIRGEAYLKLKVDRVAMQDASAQMALLQFMTCGLGGTAVPASIHCDHMIVGEKGADVDLPKSIESNKEVFNFLESAAKKFGIQFWAPGSGIIHQIVLENYAAPGLMMLGTDSHTPNGGGLGAIAIGVGGADAVDALVDAPWELRAPKILGVRLEGELSGWATPKDVILNLAGQLTVRGGTGYIIEYYGPGVQTLSCTGMATICNMGAEVGATTSLFPFTPKMTSYLNSTRRAPIAEAAEEANKSHNFLRADTNAAYDQVITINLSELEPHINGPFTPDLSTPLSKFKDVVKENEWPEQLSAGLIGSCTNSSYQDMLRAEDLVKQAAAAGLKPRVDFFVTPGSEQIRATLERDETLDVFEKAGGTVLANACGPCIGQWKRSDISKGDTNAILTSYNRNFRARNDGNSQTMNFLASPEIVTAMIYSGDMSFNPITDTLPTPSGQPFQFSAPSGSELPSQGFELGNLALFPSDSTPSPSTPVVVSPTSSRLALLEPFEPFGSTDLKGLKVLLKVKGKCTTDHISAAGSWLKYKGHLENISNNTLIGAMNAETGEVNKAYDANGDAFSVPDLARRWKAQGLSWLVVAENNYGEGSAREHAALQPRYLGGKIILAKSFARIHETNLKKQGVVPLTFASEADYNLIGSCDSVDTVGLYDMLVNRGDGEVFLDVTKKEDGSRHRIPVKHTFSKDQAGFVLAGSALNLLSKKAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9N7</accession>
    <name>A0A2T7A9N7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9N7"/>
    <dbReference type="STRING" id="42251.A0A2T7A9N7"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="787" mass="86970" checksum="CA585912EFA39E14" modified="2018-07-18" version="1">MLSRRYTISSSSPNPSSKDKSRVRRAKSTSYPITKSELLVPEERSQHAVAAAQRAFDHDIQRRNFKHEHTVFRSPSVRFLSPVDNRNKTGDADGFRPVNGQGGEKFLSAITKDASYISYDLAAGASHSTCTSRGDTVTMKLRTLKQSDDENGAFSQPRSSGPRTCRAMNLSDLGADYYSSPGSPVPSTPSSYRRLRKAKSVFSVSQVHPQRTPDQSSAAFSSELPLNEAMQQQQQPYVKEQKPFYLSASCRRSQRPVAFPETMRAKKVPKEQPTDFISFRKAMGETAKKVFGSMRRVFRVHGKLEDTFPKQHVPASRSHFSDYVSPSDLHSDIQDIPEPGNIRMHPNTASRAPTFCTVPSFEMLHSIAGSIRDVTPNPSQSPVSTIRGVSVPTDGTSTWNSTLDRRSASKKRLSIIDENIPHRIRENLYEPSTVGDLIQPRYEARRVYSALMKHLDRPTNAPQERQQYAHGPRHESLGSGCYMAGGLGLRPEEESTFTKPIELGPGRPTATAIRKSAVQKWGRPVEATRDKDSDPFYIPPVPQTPILYSPTAHKMQDIDSITAGWQETMEGADEEQVRLIAALRALSPVPSTSRESDWKDTQNSRGSATTLSITPQSTRTSPRRLRQTSSIPFLPSPTKGSFGEIAPSCYRSPKSVGTLGTENASITPPPPLRPPPLPPALSATAEQPVHDRDESSAVAGEKFKIRGKLRMKDYYSPNTAGAANSSKLRVYPENQGLGLERSRSALAERASREIENAVNSQFGPVINRRAPKTLARVESLESSIAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAP6</accession>
    <name>A0A2T6ZAP6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1059570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000516">
        <property type="protein sequence ID" value="PUU72516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAP6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="7493" checksum="2FC00802BB686BEB" modified="2018-07-18" version="1">MAIPTVTKAPVVDVLSRTVAADTTTTTTPAAITSTSPRVLNCLLTGGVHQTPKKQKPTDPAEPTLPRQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBV7</accession>
    <name>A0A2T6ZBV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1007162</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000441">
        <property type="protein sequence ID" value="PUU72926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBV7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBV7"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="211" mass="23578" checksum="AF97A892F3DB1AE2" modified="2018-07-18" version="1" fragment="single">MPFQKLPNGVILQVSKYQSPPDLCSLLRASRDLANLLSDALLDCALRSLPETERYAKGALYSAVNRGDELAAKRLIDGGIFKRLDEKKLLKRILLDHERRWGEKALPTLLACGCDPETRDSEGRTLLALAATHGLLEVVELLMDRDDVDINSTDNGNNTPLHMAVEVGDYEVVQLLMDDERVDVNWPNNSNRTPLHIAVMMGHDEVVRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCA2</accession>
    <name>A0A2T6ZCA2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1005929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCA2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCA2"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="286" mass="32498" checksum="BE22673FE9C9F78C" modified="2018-07-18" version="1">MLNRASVRNVHIYDANDPGIVLGGLVLTNGVTTANFYSMVEIVFLFNQGYTLRDENGITVGRDDHPLQPGKYFIVTAGSITVSDETWLVRAAVPATTYPEEFCHAVRERDRGCVMTGKGARRAAVGYWVGLEAAYVFPLAYEHHWIKHNYGDWITLEPESRRSINSVQNGLLLWRDLRIYFDSYMVSINPDDNYKIVCFMYDDNNIAGTHLDKAFVEDPKRPVDQVLRWHFRQAVLANMRGQGEPVFECDFPSGSYILDDIMSGPKAGERMEFELFTRLAGYSICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCS9</accession>
    <name>A0A2T6ZCS9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1197010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000390">
        <property type="protein sequence ID" value="PUU73300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCS9"/>
    <dbReference type="OrthoDB" id="5489517at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="183" mass="21313" checksum="C694BE5FC7985C50" modified="2018-07-18" version="1">MPMLEGAILSQLMGFLHNGTGTNKDFDMVLLQFEKVVHDMVISHFKIPEESVGKFIQEQIQEIHKLFGQVQAIAESYQLWGQTPNYFCKRDIAKDLIAVMENEESVHDFLNTKPYVDHWGGMGDQDFIDLARRIVIDLNAMHEHADEDNKFMALTRQERIQDLLDLLKKCRGILSVRYYFHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDA4</accession>
    <name>A0A2T6ZDA4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1094969</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000373">
        <property type="protein sequence ID" value="PUU73478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZDA4"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002416">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1215"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1245"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1283"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1326"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1355"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1386"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1480"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="192"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="871"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU73478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1513" mass="169400" checksum="8E32372FDD86336E" modified="2018-07-18" version="1">MADKPVVGHSSPSRTAQEATPPSQPLSTSREYSEKAATDWSISQSPPDPTSNDFSLSGDQKLRRAPTASSISSNPLVTTETIRPAPPNRQNTNLTRITSQLSEDEIIRILSRRKTNFSSVIEDHGPEASAEIEALLSSIFGKSRQGSNEKTQHLGVVFKDVVVKGQGLGAALQPTNGDLLLGPLRAVRGLLPGGEKVENSGHAVRTLIHGFSGCIRPGEMCLVLGRPGSGCSTFLKVIGNQRSGYVEVNGDVTYGGTDYKTMKKNYRGEVLYNPEDDLHYPTLTVKDTLKFALETRTPDKDSRREGESRKDYVKEFLRVVSKLFWIEHTLDTKVGGEIVRGVSGGEKKRVSIAEAMITKASVQCWDNSTKGLDASTAIEYVGSLRTLSNMANISTLVALYQAGESLYDLFDKVLLIDEGRCAYFGPTENAKAYFEGLGFVCPSRWTTADFLTSVTDRHERQIKQGWEGRVPRNAEELERAYQQSEIAAATQKDIAEFESIVAAQQEERRRQATEKARTQNYAIPFHKQVYACTKRQFLVMIGDPVSLGGKWGGILFQSLIVGSLFYNLPQNSNGVYARGGILFFTLLFNALLALAELTAAFGSVPILLKHKSFSFYHPAAYAIALLVVDLPLCFVQVFIWNIVVYFMSGLQRTASQFFISLLVVFLITANMYSFFRMIGAFSANLDVATRITGVAIQALIVYTGYLIPPSSMHPWFSWLRWINPIQYGFEALMANEFYNLNIKCVPPALVPFGPNVDPQYQSCALQGSKLGTRVVLGEDYIHTQFTYSRSHLWRNVGIIIAFWMFFAIMTAIGLEIKKPNSGGASVTIFKRGQAPVAVGRAMEEKDIEAGEKEPVVTGDEHNSEEAAEGVARNESIFTWQGVTYTIPVKGGRKTLLTDVSGYVRPGKLTALMGESGAGKTTLLNTLAQRIHFGEVTGDFLVDGRPLPKSFQRATGFAEQQDIHEPTATVREALRFSALLRQPEETPLDEKYEYVETIIKLLEMEDIAGATVGSQGNGLNQEQRKRLTIGVELASKPELLMFLDEPTSGLDSNAAFNVVRFLRKLANSGQAILCTIHQPSAVLFEYFDDLILLKRGGRMVYHGPLGNDSHTMIKYFESNGAPRCPKDKNPAEYMLEAIGAGDPNRKEKDWAEVWLNSANHTNHVENINQIITARLSQASEDQIADNREFAMPWEAQVRAVVKRTFINYWRTPEYTIGKFALHIFTGLFNSFTFYKLKHTSIDMQSRFFSIFLTLTICPPLIQQLQPKFLHFRDLFQARENASKIYHWTAWVIGAILVEIPYSIVAGTLYFVAWYYPVGFPRDSFTTGYTYFLMLLFELYYVSFGQAIAAFAPNELLASLLVPIFFLFVVAFCGVVVPYAGIPKFWRFVYWVSPFKYLVSGFMGALVHDIPVRCSKNEFARFNLPPNVSNCAEYTADFVKRLGGYVEEENGVCKFCSYRNGDEFAASFHVSYNHRWRDFGIFWVYIIFNFAVVFFSTWCFVGGWRVVLRLFKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDF7</accession>
    <name>A0A2T6ZDF7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000376">
        <property type="protein sequence ID" value="PUU73444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDF7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="29462" checksum="513192817EC582E2" modified="2018-07-18" version="1">MSERVRREETQKGQGKRVYWGGVGTARGGGKTPGRQWSETQLSDATGVKTHDAAPARQTHVKFLLMLVTEVYQYCPYAAPYGKIMAAWGEILFNLQAKGFYKNIKSALPTLRKDIHDLIAYKEGLGNEEQIAEHLGEVGSREQVESSGIINEQGNCKQFPFSREMFNYGLASHLERIADDMTAIASEKEIRSKEKRKGEDDKQRWGELIREAACTGLVRSDELNTSTKRKTQRHEATYHTPKKIHRTASGGVRTEDSLLSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDK9</accession>
    <name>A0A2T6ZDK9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000368">
        <property type="protein sequence ID" value="PUU73559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDK9"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="20503" checksum="1EAD4B9526968D2C" modified="2018-07-18" version="1">MQWSKRLQEADPLRLKSTVELEAMRFELSEAEGKPTLISAKSGPTCRISSTLPPYKLSNILAEQDGKIVKRGKLAEKISPTAGTQEGLNELAKRKEFTTILKDEVEARGLTVQRVMASFHRLDSLLSKPLRFNARATMVVRRANFTNEERAALVILLKVQERWPKGFLYYEDRSSEKDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDQ1</accession>
    <name>A0A2T6ZDQ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1003942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDQ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDQ1"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="567" mass="64971" checksum="216CD2956127CAE7" modified="2018-07-18" version="1">MTKDSILLSLPEEVIENTLKFIPDDDSALLDISLVCKKLYRLSNSPLEWRTRCRRFRYWEPRHEYQKKVKHPLPAEVDWRSLFVERIYSYKRTTMLLNEIISSPVDRIKKFNKIADLGYDAKDCLAEHANASDDVEDVLARRWYAAAAIRYIHRRQAIIGWKKLASGEDISLEYALGCFELFILKTPEGDIDDISGILDELAARFKSETANFADMSTKAKALALCTYMNREGFRGASYESYRALKNAFIGISLRTDRTNLPLTATAIYCSLATRVGLAAYPCGFPYHVLAIVRNEDGNYIYLDPFRGEGNELPVQGLEHQLSELGVGATKDEFLRPSPTTDIVLRTSRNILESLRRAPGPPDIQQEAVEIDRHSALYAALTASALLGPRITLNVVQHMARRIQDEYSMDVQFFEEDIVPKLEDRNARELLLEMCGGLRAEDSAQRPISRRENLDENDVRYRVGTVFVHKRYPFQGVVFGWSRTCAPKEGEEWMQTMGVDTLSRGRHQPFYLALVMDGSVRYVAEENIVVSQTDPVESLRKLAGKYFKRYSRAERMFISNIRHEYPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDQ4</accession>
    <name>A0A2T6ZDQ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Porphobilinogen deaminase</fullName>
            <ecNumber evidence="5">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1134835</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HMBS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000361">
        <property type="protein sequence ID" value="PUU73628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDQ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDQ4"/>
    <dbReference type="OrthoDB" id="564646at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000004">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="12">
        <location>
            <begin position="32"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="13">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU73628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="350" mass="37914" checksum="563EFFDBDAD50EEA" modified="2018-07-18" version="1">MSSYVLAQIYQSILNLIGGGGPGPMYPTHRTIRIGSRKSKLALVQTHLVRDALQAAYPDIDFEIVAMTTTGDNNQMKPLHSFGAKALWTQELEVLLLEDKLEMIVHSLKDMPTQLPHGCKIGAILEREDPRDALVMKAGSSYKSLEDLPEGSVVGTSSVRRSAQIKKRYPHLNFEDVRGNVGTRLAKLDDPESSYACLILAAAGLLRLDLGERITGYLSSPYLLHAVGQGALGVEIRDGDEDTAKLLQVLGHKETTLHCLAERSLMRTLEGGCSVPIGVETEAATDGQMLMRAVVVSLDGQNSVDVEERMEVADEEAADNFGRVVAGKLVAAGAGDILERINLNRDSVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDS3</accession>
    <name>A0A2T6ZDS3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphofructo-2-kinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1094619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000357">
        <property type="protein sequence ID" value="PUU73648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDS3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDS3"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="3">
        <location>
            <begin position="56"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="492" mass="56984" checksum="83072927EDC8A838" modified="2018-07-18" version="1">MARAVVDWYDFHADYEYSTDDVPVSRLRRRSNVNVDAIHDFPVDSEMAPAQLYSTESGRLFHSGKIAIVTVGLPARGKTHVSVALSRYLRWLGVKTHAFHLGDYRREHMGPGNDVPHDYFFVNASPSSVKLRQTILQKCRFDLYHFLDREMGQVAIYDAVNPTAEGRKQLSKEFLKHEIQTIFIESYVDDPKIIEQNVRGVKISSPDYQGWNPNDAVQDYIRRMGAKIPHFETMDEHELNYIKMINAGERIIVNNCRFGYLPNRIVFYLMNLHIKSRRTYFARSGVATGEDSYKADGLLCDEGESYSQRLCNALLEHREKEREEFVKQGGNDEELKPLTVWTSTRRRTVQTAAHLQERGFKVKQRPQMSQLNPGNSNMTEEEIKAHYPADWDKHQLDPYHHRFPRGESYHDLAVRMEPIILELEREKNDLLIIAHESVLRVLYGYLMACSTSDIPSLKFPRNEIVEILPESYNNRAKRVPIPHTDTNGAYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDW6</accession>
    <name>A0A2T6ZDW6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1003972</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000364">
        <property type="protein sequence ID" value="PUU73594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDW6"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="195"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="571" mass="64500" checksum="4A62C2BAE8F6BC79" modified="2018-07-18" version="1">MLSLLSSSKGKGPRGGRGTLSTSLDPEETADQAMVASLNQAIEILNELFPNVDVDEFRHMLSTFSEESRLHVITEALLKRPKDGRVQKRVVEPWEKFRSEAYRVAAKNLLYKEFKGLAHSTIRAVMAENNFDYARSRLTLTDIAGKSWRFSFTSFFRGARSLIPPEPTVTATGCEELDDELFALGKPTRDRQVDEDLKVAKLLNETEHAASSEMVEYGHFFCHQCLLRSVQEGLYGQGRNLLGEVSSVRCLSCSASPPCSAFVPHELLLAILPPDILHSLEDKTAAESLERSGLDLARCPFCPYAEVVALEEYRIKRSAKVALLVSFLVLFSIIPLALVAFLILVLTMMLMLRSPSLPRETSNSIQWILSLTGFRERVEKSIGRIQRKRRGNFFRCGSVRCGRDSCLECGSEWAPFHKCYAKEEDSVRIYVEKAMADAIKRTCPICHISFVKSDGCNKLTCPCGYVMCYVCRAEIGSESYKHFCQHFRQVPGTPCDECDRCDLYVQEDEAAAIDRAAEKAEAEYFRKFKKPEGWKYKKRDARTSRSRKGVKLSWPELIDADLDRILDQILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE09</accession>
    <name>A0A2T6ZE09_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000351">
        <property type="protein sequence ID" value="PUU73709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE09"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015570000" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="95" mass="11022" checksum="6D17199A4EA9999F" modified="2018-07-18" version="1">MIWKIWSWMLALVVSNEMPGRRFKVTCSVTPVLERGSGRRARVRIGKRRRRRVNFMFTGGGCWGYARKAVVEGERRGDIWFFNIPSASRQTSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE42</accession>
    <name>A0A2T6ZE42_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_510851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE42"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="273" mass="30863" checksum="7F3AA96B03CC47C5" modified="2018-07-18" version="1">MAPLPIEDVSSPQTPSPHPNPEPTAPHDMHYYLTEGLGGVEPRQFRDAKSFIRIIESQAGKLCSGKASQQYAVFAPMTQDQFATIDRIRRARLKGHRFHYFNHEETLIVKIMAGPVQEMTSKGFRSRGRLRVETSEVSPPWNRLANACHRMWGFSIPRSLGGRCSLVVRELRRTGEIVLLISYSASKKEIRLQQWELVTIPDPHVTHGQPRPTRTAPAIMREIDLVAGVSNEASLMLNFESVFLRPPASGEGDFTFSRKELERFSTNVWKGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE90</accession>
    <name>A0A2T6ZE90_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1196649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZE90"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1354"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1525"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1643"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1668"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1984"/>
            <end position="2021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2674" mass="291347" checksum="C14FA95B726D2CE3" modified="2018-07-18" version="1">MAESDANDGSAHEGNPMVLSVMSSSTKRRVHELHSLTERIQRSELPQEEFPLVIQLLFKTHPYYYDRNSRDAVRKCFLQMFESETLSSAYIRYLVAATKNESQKGGIAPSSAFVLLEWASVIISQISKSLELFNAHINDLLAAQVSLLELCMGSPHAKGSLKKSALTVARRGLRAAFSTKNEYEAIIKTMVEGLIAKGSTSTQKNALLLGVISGVCARVPKLREVLGGLKKGIYEFYARELIMSRTPIPQYISGSLHDFFQEFTTLEEFEAELVPALDKALLRSPEVALDGLITSLFKSLSPTIDISKAIADKLLKPLLSSIKSSNVNIRNGAVLAFTTGMDKSLEGDERAIGKIIDELVSPVKAGKVTAADQRVLYATMIETLSLSDHVGGNFSANLAEIAIKEQNEAVLLKLSSAFFNSLARELKKEIEPVKGMVDTINKGLTDKRQNFRRTWILKIGDLIWDMGETPNTITIKFCEKIMQKMVDSWAEVVTNPLPAAQTGLVTAGYVFTALALDKMANWDNEKIALIVKKADIVKQCLATTPKLSFLLNHKVYSKLTQVDDQKWAIRALAATADYVKYEANHADAWALAFLYLLCAHNSPLEIRNQAVSALSSAYLRRPEAIGKVVLNGVWQWLRKIENHEKDSAPSAAKTEGIYIGLAIHAICLSANTAGGLGIGAGLEEMVKNQLVNLAVVTHHELMPGVDWIRLCQKTGIDPGELASEKAAKLVGEIRMYTGLSGRSSYIRGAALKASATLAFVAPVAITPLVIRLFTDDLNPALLRGIGPQEVAVWKAPPGIAYVNVLSKSSASVRQEKSKDADTLKWEAELRAQLAQKKGAERKLTTDEKARVEEQVAKEAVIRKNVEEVNLKLSRGIGVIQCLAEGPPTAVEMWMGAAVRALLKVMEAGAGVVIGDSGVKAYLACAEHVSTRLGVLRAFIGIASLRALKVGELSPEVQEEPLGALATRLLYRLRFTGEQRPFDTVSLVYLLSFVSLVLEKGGIGAVEASEEADEQIVLAIEFLSFHTESCIDPNVPRGHILKLLINSMQRYTAHYKLIKDCLLDLCRCVASSISLDEIKILVGGVISPEVNVRTATLQAIDAEIDLTDFDFAEELWLACHDELDENAELAKSIWEENALEVHQDSARKMIPFLEYMDKPLRAAAARSLAEAVRQFPDVFSNTLDTLQDFYREKAKPILPAYDEFGMLKKVDNRDPWEFRSGIALAFKELAPIFVSARLVGFCAFLIEGGPLGDRNHTVREEMIEAATAIIAAQGATHVEELMEVFEQSLEGPDDGSELRDRINEAVIILYGALGRHLGSGDKRIPGVVDRLLTTLSTPSETVQYAVAECLPPLIKASRDKAPDYIKKLLDQLFTAKAYAARRGAAYGLAGVIKGRGISALKDYRVMSALRGAVESKKEPNARQGALFAYELLSLILGRLFEPYVIQILPLLLQSFGDGVIDVREACSDAAKVCFSSLSSYGVKVILPDLLEGLDEPAWRSKKGACETLGAMAYLAPHQLAISLPEIIPPLTTVLNDSHKEVRAAANRSLKKFGEVISNPEVKDVVDVLLKALSDPTKYTDDALDVLMKVSFVHYLDAPSLALIVRILERGLGDRSATKRKASQIIGSLAHLTERKDVMVHIPILVSGLKQAIVDPVPATRATASKALGSLVEKLGEDALPDIIPGLMATLKSDTGAGDRLGSAQALSEVLSGLGTQRLEETLPTILQNANSSKPSVREGFMSLFIFLPACFGNSFSAYLSKIIPPILSGLADDIESIRETSLRAGRLLVKNFATRAIDLLLPELERGLADNNHRIRLSSVELVGDLLFNLTGISGKAEQDDLEATGEIGNSLLEVLGKEKRDKVLSALYICRCDTSGQVRLAAVAVWKALVASPRTLKELVPTLTQLIIRRLANSSTEQKVIAGQALGELIRKAGEGVLSTLLPTLEEGLRSATDTDAKQGICIALKEVVDSTSRESLEGYEATLVSVVRTALVDADRDVREAAAEAFDALQKLIGKRIVDQVLPHLLSLLRSEGDAEHALAALLTLLTEQTRSNIILPVLIPTLLSPPISNFNARALASLANVASSSLNRRLPNIMNSLMDNIIICQDEELLSDLNASFDSVLLSVDESDGLSTAMSEMLKLVKHDDHKKRACACEHFARFFAETDVDYSKYTQDCIRVLLISFDDRDKQVVKNAWSALNELTRKLKKEEMESLVFSTRQVLQQVGVPGAELPGFSLPKGINAILPIFLQGLMYGTPDQRTQSALAISDIIDRTNGESLRPFVTQITGPLIRVVSERSVDVKAAILLTLNSLLQKIPTYLKPFLPQLQRTFAKSLADTSSELLRTRAAKALGTLITLTARIDPLISELVTGAKTPDPGVRDAMMKALYEVVSKAGGNMGEPSKASILSLIEDDLDQDDDRMAIAGARLLGVLVPHLSPDDSSRVIRTHAVSNAFTKASVLGLNAVLAESPASLTEPPFFEETPSIISQGISHKNPFISDNCVLAAGKFLISSDLSKSFETTKSILESLTQAIKNPLSASTDTKRLALVVIRTVSRLQPEIIRPHLPLLAPVIFSSVRDIVIPVKLSAEQAFIAIFQVVQQGDAVFEKYIGTVEGPQKRSMHDYFRRVAMKLAAAEKERNEAGGAGLGLNSDEEEDMKEIMSVGRVDSEGWTSGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEV4</accession>
    <name>A0A2T6ZEV4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1110910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000327">
        <property type="protein sequence ID" value="PUU74021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEV4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="171" mass="18545" checksum="8EB1675923B7F98E" modified="2018-07-18" version="1">MINHRPKRKSTKEFNSCPITQTEHCKPEMNPPSRKALLLESSLESPSRPPPPAAAAAAAAANTVIHVNKRQSHARPNEQSKSSNHGNATNQTKPTNQYFPTGAEHTNPNVKDLTVPLPNGCRKSTPNQPHMANLKLPCGTRTQAAQQPEPISSKAPVKVSALSLFRELQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEX2</accession>
    <name>A0A2T6ZEX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_490198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000327">
        <property type="protein sequence ID" value="PUU74019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEX2"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22131">
        <property type="entry name" value="F-box_FBXW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="321"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="443"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="528" mass="59644" checksum="7680C454BC99BE1E" modified="2018-07-18" version="1">MPSTPVNSPSRPRSALRRLPSYRSLSFSASKLSLSHVTPDPTNRYSLNKTDGSSRIENFCSHPIKSTSSGVRKLLQKASHSLRFTHRNELLGGMKRDKCPSTLGDDESGIVIDDKDNDCFYAIDTTVARKDFVKFLPPEITAHIFSFLDHQSLVNCESVSRAWMVAARDRHVWRNVFRAEHGPWKSKPGNDWKRMFKVRQELNLRWTQGRVTAKYLKGHTDSIYCVQFDDKKIITGSRDKTIRIWDISTGECIRVLGQGSRFSSPPLIANTDIAAPHMSYPDYHRASVLCLQFDDEILVSGSSDYTCIVWSVHTYTPLMRLAHHTAGVLDVCFDKKYIVSCSKDTSVCIWDRKTGKLFRQLTGHRGPVNAVAIRGNLIVSASGDALIKLWNVDTGKCIRDFTGHNRGLACVQFSEDARTIVSGGNDQDIRIWDATSGECIRALVGHQSLVRTLHLDSRNRRIISGSYDQSVKVWDLDSGKLVLDIQRFHSTWILSAKADYRRIISTSQDNRTLMLDFTTGMKDLEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFP4</accession>
    <name>A0A2T6ZFP4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1103511</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFP4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFP4"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14081">
        <property type="entry name" value="STKc_BRSK1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000394">
        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="111"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU74303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="434" mass="48687" checksum="72CA06F3205F138F" modified="2018-07-18" version="1">MEHRGKGDRTSYRDSRRPLQDTPVNVAYSSPTRAPAPPNYSKPRPFDRQEQQQATQQTSTRSYKQTDSYGSVGTGEYIGDISSGPVDPPSSPPAQNPNAHRARVKAQVGPWLLGRTLGKGSSGRVRLAKHVETGQFAAIKIVGKGNDGAIGESGQERPLPPGLEREVVIMKLICHPNVMGLWDVWENRGELYLVLEYIEGGELFDYLTRRGRLPEPEAIIYFRQILSGIDYCQHFNICHRDLKPENLLLDSNGNIKIADFGMAALQPHGSLLDTPCGSPHYASPEIVSGKHYDGAKSDIWSCGIILFALLAGYLPFDDDNIRKLLQKVMKGRFVMPVEFSIEAKDLIMRMLTIDPEERISIEEIWKHPLVQMYAPLDPVTGEETDRGPKPPRSRDIGRPVKYRRDIDGEILKNLQTLWQGVEEDTLIERLLNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFV1</accession>
    <name>A0A2T6ZFV1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1133424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000304">
        <property type="protein sequence ID" value="PUU74381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZFV1"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019799">
        <property type="entry name" value="Glyco_hydro_22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00128">
        <property type="entry name" value="GLYCOSYL_HYDROL_F22_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 22 (GH22)" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1342" mass="148431" checksum="530BB7D2CB8D7035" modified="2018-07-18" version="1">MAKRKGNGPAGNGHRNRPRKSNASSSSGSAVGSPSTPSSARDSRLASLTPIRGTPAHEVESTDSGNRGSVSDNGSAEGWQTAPGPKTATRRKFLPKNGGGPLRKDKHELPALKIEGAPDDDDDEEEDGVSTTGGGAPTQTKGVAKNPLVFMFETESTENSPDAWRRCPEVPSISELLRERVELPINVIDGPYSSVDDYLEAHYELLKEDAFAGLREAVCHMRQYPDAEDTNDLAVYDHVRILGLTFAPMGVCCKVSFSLNRAGKRVRWENSKRLLPGTLVCLSHDNFKTLKLATVAARPMAGLELPVPEVDLLFSEGEIEFDSTETFIMVESRQGYFEAYKWTLKALQRMNENNFLLHEHICFLDQDVPPPDYLEKSPTLNLSSLFPDVRDRESLEEVDVLRGWPAAVHSTMDKTQQQALKTILTNRVAIVQGPPGTGKTWVSVVALKAMIKNMDRNDPPIVIACQTNHALDQLLGKILEFEDNVVRLGGRTQDRGKIKERTIYELGMRMKKQIVGSKLGLARAQKEQLTQKMIDLLETLQPELLTPETLRRYGAITEGQEASFYSNRAGWITYEDDEQPTGVMSDWLGDSFTHIIVAANLSDEYEEADIEYEALKEMEAEFQTTLQADEFDDSLKGRWIPLAHKYRVQIPFMPSDDEIRRAMKSKNVWDISDHVRPAMYQRLKSKVTAGIRRKFDEYNFTYQRLVRDLKVARLEKYAYILGSAKLVGLTTTGLSKNRSLLAAIQPRVLLIEEAAETLEGLVTAGCLPSIEHLILVGDHKQLRGHCSVSELAGAPFNLEISMFERLVNNGLPFDMLQEQRRMRPEIREILTPIYQDLLKDHSCVLGRPGIPGMGDTHVFWYSHMNPDQMDNGTSRINTEEAAMIVGFIEHLVLNKTSPEKITVLTFYGGQKHEIIKRVRRNNNLKACELRITTVDSYQGEENDVIILSLVRSNPQGSVGFLNVQNRICVALSRARLGLYIFGDAQMITRADKTWWEIGKILNTPPSRIGFAMPIVCQKHGKLEFIKESQDWVDIVGGCYQWCKETLPCSHICRFRCHPFDHKDIRCLDACLKRLVCGHQCQGDCYKPCHCLKCDEKQVLSDDASNSRASTRSESIPGPLTPIQSTTSSSLIDTSLGHDSAWNYQDIRNEGLHAGPRSAIAQRDKAESDVSSLDNNQKSVDTHSLGQPIAVNAQRSLGSRGGNVLPKPVATIIAGGDGTPVAQPANSIMEVRGPITERRIIGGSGPMTTQGPTPAQQSPSPRASPRRPQGPGAGRGFFNTGPASPPSGLSYAKSVGGRQQNGGPSSGTQQSTTWSSVAGKPQPQTSKLPDGGANRYGGDYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGF9</accession>
    <name>A0A2T6ZGF9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription initiation factor IIA subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1000467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">TFIIA is a heterodimer composed of the large TOA1 and the small TOA2 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TFIIA subunit 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGF9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGF9"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10014">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10145">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.190:FF:000001">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.18.10:FF:000003">
        <property type="entry name" value="Transcription initiation factor IIA subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003194">
        <property type="entry name" value="TFIIA_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015871">
        <property type="entry name" value="TFIIA_gsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015872">
        <property type="entry name" value="TFIIA_gsu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10966">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02751">
        <property type="entry name" value="TFIIA_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02268">
        <property type="entry name" value="TFIIA_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009415">
        <property type="entry name" value="Hum_TFIIA_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor IIA gamma subunit C-terminal" evidence="11">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="13054" checksum="36E93B6A456B670A" modified="2018-07-18" version="1">MNNQTYYELYRRSSIGTALTDALDDLISEGRIAPQLAMKILSNFDRGITEILAEKVKANLSFKGHLDTYRFCDEVWTFLIKDVTFKFNGQGQGQNPSVTADKVKIVSCNSKKPGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGI8</accession>
    <name>A0A2T6ZGI8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_999659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000289">
        <property type="protein sequence ID" value="PUU74589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGI8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGI8"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16984">
        <property type="entry name" value="CID_Nrd1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000026">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000397">
        <property type="entry name" value="RNA binding protein Nrd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048892">
        <property type="entry name" value="Nrd1_Seb1_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21380">
        <property type="entry name" value="Nrd1-Seb1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CID" evidence="10">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="519"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="646"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="673"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="749" mass="80820" checksum="84046E0C93280FE9" modified="2018-07-18" version="1">MSAVVTELENALQAMQATKAPGVSGTKINQITELSLRNVQSESVIIQKVYTHFKKCPGTHKLGPLYVVDSIARKYLEQAKRLHEPVSHAAPDGTFGAGVHRITNLLPALMNDILQNAPPEENKDKIDKLVTIWERSSTFPLEVLAEIKQKIATSPMSIVPNARSTTPTGSPPPHLQSLAGQIQNLPVYQPPQAHQTPQSVIPNTQSQNASTTAGILQALAQMAKQNKTAMPSQAPSQQQTPTPVPQYSAPTPQPQPGGMPNLTQNASSLVVSQPQQGQVPMAQMPYTSAPPSQNPNATIPMMGNQLSGMFLGQPGQRQFPNFPPQPPPPPPMPQQGAAPAGIEQMALLQLLLQHGGMSLPQLTQSFGNLASGQGGPGADLGAVLPAWSQIMNAAQGQTQQDSSRGGDDGYGRGQRNREHYSPPSPFRRRSPVYGEYEGNDSRGRDGDRNRGGRGRGGGGFGRRGGSPRSRRDRSRTPPRFANGKGQAERNVTPTALPKFPKHVEFDPTIGPNNIKVLSRTLFVGGVTISDDELRKLFEKHGYVQSCIVNQEKRHAFIKMLTRQDAVKARQGMETYRADNMTIRTRWGVGYGPRDCSDYQTGISVIPIDRLTDADQRWMVSAEYGGTGGRPLEGGMCVEEPDIEIGQGVSSKAISKRFPTDSGGAKGPRSSHDNSNNGAGNTSGSSTTQREPPRTKRNDYSELHDRTGRDSNIGVAPPTPGFGTGLPFPMGMMPPNMPPGYQYPGFPNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGI9</accession>
    <name>A0A2T6ZGI9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000288">
        <property type="protein sequence ID" value="PUU74613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGI9"/>
    <dbReference type="OrthoDB" id="10428478at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="674" mass="72136" checksum="5D0995B1E56D1D7F" modified="2018-07-18" version="1">MSGNKRNKMSSGPIGPILDIAPTTNPGPKRARVGAKTEGSNLISTPSERRAALQASTPEIDASGGSPTQQLDPGPSPHSVIGSILSETTYPPCFPLAEKVEQTSGLSNPQASPEHIYRGQSNYNLPRSPPSEFEADKNFFEEIYSGQNAPMPPCQSAGSLHPGAQRTLCHSPDESNVHSSYDYKQNSLSPLYPSVGVPANFVNRPSGVPLEVPAAQLSQLGLSTDSGRPEVKNQELSGSTQLGVPSGASIHLGQSAPISSDSALMLHHSEETSNRAVRTCEQAAPEITYQKNPISLLLQPFHGTPIEAPDDLVSTSAFTSTGSNQSPGVFLQNLMEDIPSEAYHFEGEWLNPSPSAVLGFDSLAKDSPPMPFCHGIPFPGSVSLDSQGWGKRAEAHLAEKATLGSQSTPYSNLSSIISPRGEYSSSEFSVLTGQAWAPISMKGLEDYGGPSNEGEGQVMRPSNSYAGVFANCSTEHGTVYSTPALKRCEWLNISGLGGEGDGKEVYGDLPYNWGEASVFSSPLEALNKPVDEELLGRNEVAHKHSKDLHRPLDIPPCKASNATPVIDQSWRKIKLPLVTFRGPWQDIPNPDEDAMGGKYYGEILYSWASPEHKPNHPGPASLTACSLPTSNSKSTIPKGKKQAVKPLSIIERRMARQRAGVRKSSRAKNPPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGM2</accession>
    <name>A0A2T6ZGM2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1132958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000286">
        <property type="protein sequence ID" value="PUU74637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGM2"/>
    <dbReference type="OrthoDB" id="5503129at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47371" checksum="51D57259F9C3DBC0" modified="2018-07-18" version="1">MSNLGRNKSTWYEQQHSQDSSEESDIGTHSREGSPVSEKPHRRIPGYILEMDSQQYNPDTDGGSGRVSETAELVCENEELWTALGRLQEQMASLVAGQAEARPAVHFSRPAAAQATQSDLNDWILRQQLKKHTIRKFLGAIDYEAVLLWTEAVSHFALLAGLNNNATITAAWTAIEPEILVWFKAMLEADYDYKFVATAMDYPFSCEQVKTKFAHRYSPAFAVESGWNSLEALKRGTGTTALQEFNTKFLELASIYVKKMTARERDILSAIAISAYRDHKVITLDDAMAITDDQAVIYSLTVGSRVAGNSVPIIQAFTSFSHPTAPAPIDLSVITSYPVAGTRRDRNVCTRCGGKGHWLASCGTKPEWKEGDPVSGYRGRGGTSRGTRTFGARRRGGTGALHLMGEGVGDSGIAVDGVDTADDGIAGSQELPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGW6</accession>
    <name>A0A2T6ZGW6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DUF221-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1092098</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000277">
        <property type="protein sequence ID" value="PUU74727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGW6"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="702"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="747"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="795"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="853"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="937"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="210"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="558"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="656"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="1052"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="384"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1013"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU74727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="127105" checksum="8444779FFA5634A4" modified="2018-07-18" version="1">MSNSSSTIRSSNVTEAIGKSSGKGQSEEGMSLESFLASLAVAAAVFGAEVLIFVLLRTKLQRVYVPRTYLVPEKRRTKAPGSGWLSWFSPIFATANSDFIDKSGLDAYFFLRYLLMLLKCFCILAAVILPILLPLNSLGGRGAPKVQGMDQLAWTNIAPDDTHRYWAHLLLAIGVVVVFCYMFYYELRAYIRLRQAYLTSPRHRLRASATTVLVSSIPRKWLTAEALVGLYDVFPGGIRNVWINRDYEKLQEKVEERDKLAKNLEAAETELIRMAKKRQMKELRKKAGSSTERAQITDAAAAGEDIANGPGLSSGNPHQIPQDLHDRSHGKKPESRFAKVNPIRVVDDGFHRLGHGVMGGVSAVAGGVRRLRGGVEDYMPSAAYGYQAGDDEPPVPSKQPPQRAQEPETLQDGTQRKRGSTLAGHEAVSESSYGSPQRTRTRPTIDTSNTGAANPHPAGSQQAVVDAPPKWMFWKKRSKADDDHGKGDDDEIPFNHQSPVSPHTTHSMDLPAKGPSKEYPKAFNEKYADDKDGDPLWKQYLSSKDRPTMTLPPFGVKWLPSLPLIGKKVDTIYYCRKEVARLNVEIEQDQSAPEKYPLMNSAFVQFNQQVAAHMACQSLSHHVPQHMCPRHIEVSPDDVIWSNMKISWWQRYMRVAGITVATGALVIGWAFPVAVVGLVSQIDYLTETIPWLRWIERLPNSVLGLIQGVLPPLGLAILMALLPIILRTFAKLQGNHTGMAIERAVQGMYFAFLFIQIFLVVSISSGITTVFQQLADNIASAPAILAQNLPKASNFFFSYLLLQAFTVSGGAILQIGTLFVQFILSPIIDSTARQKFTRATELAQTKWGTFFPVYTNLACIGIIYSIISPLILVFNICTFSLFWMVYRYNLLYVHNFRFDTGGLLFPRAVNQLFTGIYVMEICLIGLFFLVRDAKGGVACFPQAIIMIIVTIFTVLYQYTLNSAFGPLLTYLPITLEDDAVLRDEAFAKDTEKRRLLASGNIVPEGNGVLAEEEKGPGLYHGSVDPEAQSQLPPPKKQPHTRPELMLFEDIADEIEDLSPEQRDILVGRAFQHEALRAKRPVIWIPRDDLGISDDEIRRTQRFSDNVWISNEYTGLDRKGRVVYRRPPPDFDQRDLVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH36</accession>
    <name>A0A2T6ZH36_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1116733</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000272">
        <property type="protein sequence ID" value="PUU74810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH36"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH36"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="16842" checksum="6A9E252A7B84D3BF" modified="2018-07-18" version="1">MALPKRIIKETERLVAEPVPGINAVPHEDNLRYFDVTIHGPTQSPYEGGIFRLELFLPEDYPMTPPKIRFLTKIYHPNIDKLGRICLDVLKGNWSPALQIRTILLSIQALLGAPNPDDPLANDVAQRWKEDEKAAIETARAWTVTHAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHH5</accession>
    <name>A0A2T6ZHH5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="3">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1067824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000259">
        <property type="protein sequence ID" value="PUU74943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHH5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHH5"/>
    <dbReference type="OrthoDB" id="5425465at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="206" mass="22588" checksum="52297B6EA882E952" modified="2018-07-18" version="1">MLDDIVREWETLQDPASRAIVYCRSHNDAKRVGQQLKCGVYHSGLKSSAAKKEAFSNWVNGGLGISKFISATSGLGAGIDIPSVRIVYHYRESLDFLGFVQESGRAGRDGLPAKSKVFLDTTSLKRLENLEGVRTSLGQQAIFEYHIKGFCRQAAISFYVDGMSTWCVNSTDSDLIHCDLCQILRSQAKSVAQPSLSDSPSGIPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI26</accession>
    <name>A0A2T6ZI26_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1091068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000249">
        <property type="protein sequence ID" value="PUU75133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI26"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6461" checksum="FBB6D01322DDD1EE" modified="2018-07-18" version="1">MYQLPYPTSTSTQVHEYPYSADLRVRLHIYPGDLAPSFPCSSIRWSGCTREKGKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJC1</accession>
    <name>A0A2T6ZJC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1116373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJC1"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="408"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="452" mass="45496" checksum="259E0ABCB0D471FF" modified="2018-07-18" version="1">MSSTEQSAQEPSSSSESSTPITFSVKSSNDTKYTVSLAPTTSVADLKTKLAELSDIAADRQRLIYSGRVMKDEETLATYKLQSGHTIHMVKGAASNTARGGASSSGPTTGGADARPTVPTNIAAGTGNNPLAGLTGARYAGHVQLPNADMFGPDGGMGPPPDAEQLAQAMSNPQFQSTMNDLLSNPQIIDYILASNPMLSQLGPEVRQMMQSDLFRQLMSNPQVIRSMSQMSGGLGRGFGGMGGAASFPEPGRTDTTPAPDSPAGSTPAGSTPNPAAAGSPPPLNPFLPGAAGGNPLAALFGGQPPRAGVPGTSPGQAPGSGGIPHGLDPNALNSIFGALGGGGDGQPSGSTGSPASGAPNQPLPPNHPLAGNNPLAILLGANGHLGAAGALRAQAQAAAAAPVDNRPPEERYAEQLRQLNDMGFYDFDRNVAALRRSGGSVQGAINELLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJV1</accession>
    <name>A0A2T6ZJV1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1089647</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJV1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJV1"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="93"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU75770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="272" mass="30310" checksum="EB343D9315AF9FE8" modified="2018-07-18" version="1">MSTTITATTAPQGQAQPITAGDILRLFPEIDSSLASSASAATNKAGSGELQGCDEEQVRLMEEVCIVLDEDDKPIGSASKKVCHLMKNIDLGLLHRAFSVFLFDPEDGRLLLQQRADEKITFPAMWTNTCCSHPLGIPGETGADLAAATQGVRRAAQRKLDHELGIPSSQVPLDKFKFLTRIHYKAPSDGLWGEHEIDYILFIQAKVDLNINPNEVQAYKYVSADELKEMFKDVGLSFTPWFKLICNTMLFEWWSNLNNLDAFTNDTQIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKC7</accession>
    <name>A0A2T6ZKC7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_306560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKC7"/>
    <dbReference type="OrthoDB" id="5370011at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="374" mass="42161" checksum="014D0BBECC563811" modified="2018-07-18" version="1">MSSGTPPDGSGGGEKSIRRRFTSQFKRVLSIRSGKSRRSTISDSAGEPSIPTTPLSPTVTVPPIEPASSSVAQPKPEPKTREKEEQEMVRTRTKPSLRQPRTTAIPPPAMTAAERAHALFKKHGLEISTDDWPLSTAPPGDRVQKDIRMRVHRTCHRCSASFGPDKICNSCNHKRCKKCPRHPVKKSKDKGKGKERVGERPGEKSGQKVGRKKKKPAYDVTLTIPSRTGGQDLVRKSPRQRIHRTCHRCQTDFAGEKICKKCSHTRCKNCPREPFKKNKPPGYYDGLDPDDSEEDKRLPTRPRRTYKKPRRRVHWICTKCSTTFIEKSKICEGCGSNRDDTGLRDPPKKQPYKPTEEDIQRLDERLKQTSLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKP9</accession>
    <name>A0A2T6ZKP9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1052692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000204">
        <property type="protein sequence ID" value="PUU76070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKP9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKP9"/>
    <dbReference type="OrthoDB" id="5394847at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="22302" checksum="8B943B43F5FF6551" modified="2018-07-18" version="1" fragment="single">MSFLDLPNEVILQIARDQDLPDTNALLRTNRRLARLLTHVLIDKLFLTNTRLQRHGRSVLFFAASRQDNVTVKRLLDSGLLDGGEILTTAVSSMNETTIRTLIDCGIDTTAKGGWRPTPLHAAVLENRPTIVKLLLGVDGIVVNSQRNGRTPLCDAIRAGNEETVRLLLCDKRTQLNQPDAAPSALHLAVNLADKGMTQLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKS0</accession>
    <name>A0A2T6ZKS0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA ligase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1088970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKS0"/>
    <dbReference type="OrthoDB" id="276239at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019039">
        <property type="entry name" value="T4-Rnl1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015966">
        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="4">
        <location>
            <begin position="181"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase kinase" evidence="3">
        <location>
            <begin position="503"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="2">
        <location>
            <begin position="664"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="916" mass="104138" checksum="0193E18BBC1AA062" modified="2018-07-18" version="1">MLSRRIVPTAPPSLLSKDIKWGASHLIIPVGHVQCVNFHRKVSSHPPFPPSSPCPKHFPCKHPCPSTWSVTKGALHTSPFTLFHSNSILLLNSIIHRHNHHHQFSTLTKIMADYSTPFMSQDPGEINGLVELLDRAQAEKKSRAGYFCKKKTYQIEGSSISVDSWKFLDREYKKKILPTCARGLFTCKNPATGDWEIASRGYDKFFNIEEVQETKWAWIEDNTKPPYELTVKENGCIIFISGLPDDTLLVCSKHSTGPGLDPDKSHATLGEKWVDRQLEKLGKSKAEFAKALREANVTAVAELCDDTFEEHVLPYEGDRAGLYLHGVNLRLPKFATYSATDVKKFAQDWGFKVVDSLDKLDVRSLREFLEEGAETGSWDGKDVEGFVIRCKARDGPDGEWHDWFFKYKFEEPYLMYRLWRECTKSMINGEEPRFTKHKSITTEYLKFAETYFDEHPVEKERYKQNHGIIKLRDAFLEHRGQKGSDIIKEEAGIQVSQTKDNMVLVSIATLGCGKTTVAHALHELFGWGHVQNDNITGRPKPQKFATAISNALKEHPVVFADRNNPEFREREQLIKDVTKLNYKTTFVAIYYVHPEDLIDEIGNATMARVFGRGDNHQTIRAATQSKESVESIMKGFLTRFRGLNPERSPDSGFDAIIELNPQADSRENLEVVVSELKRHYPNLILELPTPEAYDRAISAALNHAHTVLRPPPQPTQPKGQAIVPKKAPSVAGPSEAPKRERKQPVDNRKRRRVNYFGIFLPTQEVYAAVNSAFEAQPERIREFWEELKAKNRVQETFHVTLCHYSSEKKHPEIWKKYTDLLNSKGRDSPTILGKGDVELHSMAWDGRVMAMRVLLPGEWECANEAPHITVGTADPEIKPVESNKMLEAWNRGDSNIFSLELQGVKVVGEVGPFPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKX0</accession>
    <name>A0A2T6ZKX0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anticodon-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_991875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKX0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKX0"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon-binding" evidence="1">
        <location>
            <begin position="348"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="419" mass="46143" checksum="FD8415AD731D17AF" modified="2018-07-18" version="1">MKDLYTFDATEDAALKTYREVQSAYKALFEEIGLPYIHAEADSGNMGGSLSHEYHFPSVLGEDTVISCSNCGYCANEETARIAPPKPISDLAASRIATFHGITKNRKTLLNIHYPRYTKATSDGVLNEVHAGKVKNIISDFDPSVMNALDLWFDAFVGYAHLAEEVSYSRVINIFDARIPSSLHEEIPPNRFGKMIEKKSMEDFSIPTTSITPSNPEFGSSLNLLKIRDGDGCPKCGEGKLKTTGAIELGHTFHLGTRYTVPLRADVLNEAGEWKPMVMGCHGVGVSRMIPAIAEGYSDHNGLCWPRVVAPYDVVLVYGSVKKNAAVPPKEDIEAVYDVLASQSLVGGTDVDVILDDRDKDIVWKLKDAVLVGYPIMCIMGKSWVNSKKVEIEVRKTKARLEVELGDLRTVIEGLLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL66</accession>
    <name>A0A2T6ZL66_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1088791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000197">
        <property type="protein sequence ID" value="PUU76196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL66"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="80"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="404" mass="45817" checksum="772329FDFF9798D4" modified="2018-07-18" version="1">MGRIPNDRLRIAQSPPEMHSIQPAPLRSPTSPSSTHSQNFSNTYIQRSRPYLTDQQIEERSQKDSQTEAKEISTRLNACAWIMQIGHALQFPIRTMATAMILYHRSRLFSRNPYSEQQYVDVAAAALFVACKIEDTLKKSREILATSYNIRHPQLEPINSDSSILDDTVKRIIGIERVILESSSFDFRYRHAQPFLIKFAKKFGCSKALTQLAWDISVDVYKTLSPLKATPHVLALASLDLATRLEDQRVEIKYEQFEASREVVLSVIDDLLELYTSHKIQTIVGLGYDSNVYLTQRIQLNKERTPYTNGHASQNGTRSNSSNSQNNNNSNHYIHPSRDFLNTSPTEPIPPSAVSLERGTYGTIRFMIDPTREKTEKEQMNGSSRSKELTPPNGVVVSPWSGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMF3</accession>
    <name>A0A2T6ZMF3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histidine biosynthesis trifunctional protein</fullName>
            <ecNumber evidence="10">1.1.1.23</ecNumber>
            <ecNumber evidence="9">3.5.4.19</ecNumber>
            <ecNumber evidence="8">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B9Z19DRAFT_1087877</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="10"/>
    <dbReference type="EC" id="3.5.4.19" evidence="9"/>
    <dbReference type="EC" id="3.6.1.31" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMF3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMF3"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="19" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="23">
        <location>
            <begin position="220"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00017884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PUU76626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="821" mass="88142" checksum="A5E5251E15FC9F86" modified="2018-07-18" version="1" fragment="single">MSIPLVASLDSLSESELTPTLSFIGHISITVSPENLDTALTFIPENFHRFIFSVNVAALPSSDDICSLLNAGAARVFVTYDQLQALQPRVNDSRLVLILDPSYQTDGEIDEAISNTSVALYAHKIIDLDFAVGRLKEYGDINRPPGFVSFGYTPSLKDVEAIGKLVATPIVAADGLTVDLEKEPSKLSIGDIVLAGASSDRQDKLIPTLVTDEAGIALGLVYSSPESVKESLKTGRGVYQSRKRGLWYKGATSGAVQELVRIDPDCDGDCFRFVVRQKGKGFCHFETATCFGEYRGIYHLQKTIASRKESAPAGSYTARLFSDENLLQAKIMEEADELCQAKTKEEIAFEAADLIYFALTKCIGAGVGFQDIERNLDAKSLKVTRRKGDAKEKWAGKGVAQTSSEEIGKEGVKLVSGAVKPAIEPSSIKANERIKMARFNPKTSTPNELEEVLKRPAQRTSDIMGIVTPIIESVKQRGDAALIEYAAKFDKAVGLKSAVLSAPFPPELMQLPQETIDAIDLSFENIRKFHEGQKETGTLVVETMPGVKCSRFVRPIERVGLYIPGGTAVLPSTALMLGVPALVAGCKRIIFASPPRKDGSVTPEIVYVAHKVGAEAIVLAGGAQAVAALAYGTETVPKVDKILGPGNQFVTAGKMFVSNDTSAGVSIDMPAGPSEVLVVADAEANPAFVASDLLSQAEHGVDSQVILIAVGLSEEQLIAIEEELERQALALPRVDIVRGSISHSITLQTDTIEEAVELSNQYAPEHLILQIKDASKAVDLVQHAGSVFVGHWTPESVGDYSAGVNHSLRMFPLPLYCASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMP9</accession>
    <name>A0A2T6ZMP9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_225682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMP9"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015556135" description="Lytic polysaccharide monooxygenase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28432" checksum="EA12A2F8A9196C1E" modified="2018-07-18" version="1">MFSLALALTMFALLRCASAHLAIKDPRPLHYNELGGADFYSPPLKDDGSDYPCKGYHLTDWGAPVVQWPAGGAGTFTIDLLGVAAHNGGSCQASISYDAGRTFKVLKSFIGDCPRGAVENTLYTTEQTFDFPIPANAPHGSALFAWTWFTVTGFRQMYMNCAHVEIVNGGGGGGEVGWPAGMPDMFIGEINQCKTQEFSNLYFPDPGSAVQFGGKTNWVNAGPVGVCNIPPDVPPNALMPGRMARMARMLKRGVEVVKIAFGGSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMQ2</accession>
    <name>A0A2T6ZMQ2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1087626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMQ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMQ2"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="133"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="545" mass="59549" checksum="42DB3E351BF82530" modified="2018-07-18" version="1">MPLTKTPWHPLPLTTPNRSIPPLLLQSTFTSATYTIHLTDLVNIWSESLSKREILARAERDSSAIDPTEDVSQLPILLEKLESALGRNRDDDTVDVGISLGKSGLRLKTTVELPRPLGDLKWTFELKPAGGVELVNLLVLPALSEVATLRDMVESLMTVVKEKDTVLERLVEGMGEAGMDVRTTVGGGRRRRGLEKFHVGRWRGEFLGGDKRAGEVISEVFGQDSEQEIPGVKGLGGEAGEWWRGLDEDGSGEEKENPPRKRSETRGGIQGRFLQKPIPAKPTSDTDDEFKVQKTPPRALGRTPPSIKRPQSISPPPFRRKLKSPTPPRAHRAHDETASKDDDLGVGLPASRKPASPYVSKALSPPKISPPPTKRAIGKIGGAKKSASPSPAPLDIPMADTEETGDEDDAWISVNKGKGKEKETEANDDIPTSRAVNKGVKMVIGGWKLTPEPAHEEEKAAPAKKAIGKIGKVGGRKIGPGENMMVKDGSASRVPSPPLIPPEETVKEEVEEEEDEDEKADRKRRQLQKELEAKKKAPVKKKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN40</accession>
    <name>A0A2T6ZN40_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1129027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN40"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN40"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9234" checksum="A8C9F68DC1B96381" modified="2018-07-18" version="1">MPATDDPEQEVIIAVMGVTGTGKNYFIREVSGISDVKVSDGLHSCTGEVQPYFFPYAGVKITLVDAPSFNDTTKSYTQVLRDICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN91</accession>
    <name>A0A2T6ZN91_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_205440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN91"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN91"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="600" mass="67611" checksum="334920DAB7FDDADC" modified="2018-07-18" version="1">MSPEDHLGLAGEAEKGNEGGAKLGSQRNAFAYQGSHADWVKDNIVLCSELKHLYVGVTRARCRLWILESNTCILGPVQRLFNQTAKELLPHRYPSPILEILTEQDIGISELHKRLSTGRTISVSQWREMGYQMIDDQKYSKALRCFEDAEDPYGIALANAYITEQSGLTNRALGSLELANLDFIKASEFFLKARSIAKAVQCRKEGGDPKGAVRILADNGAYEDAAWLSADVGLFLGTSEIYTKLNKHERALTGYARAKQFKKMFSYIRKFESEIEPCCLKQYVLFGYLTEFGDSDTTPSDFEKRALNLIGSPEEQEMVLSRFSLKNKLFEMLSTNGKYMEAYQIGIGSGLVRNSIELLSENLLLKNLNREQGVQLNMLCKFLQAEHIATNPWPRTKEGGRIHKVLRAAVGMGSSQINSFVKMWEDINRALDGSARRGTGVEMGKLRDMQTASYVDILVTRSACPNNEFRLPFDHIERMFEDLRIISSHGTIPYSAQIYCGIYEPPGQLGEHILLEWSPLRASSKLRLPPRAVDIESLRGKILRYILGDIVPPLISLNEGLRKIWSKKAEPQFPPPSILADAYFKKVECASRWCAFAEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNK4</accession>
    <name>A0A2T6ZNK4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_988158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNK4"/>
    <dbReference type="OrthoDB" id="5373102at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9932" checksum="677DBF692448EFA2" modified="2018-07-18" version="1">MCLISPREDDYAPARQVHVYRDGRISREYMASPRRSYVSTSSLGGGGRRSSTTHVRHVYHSSPRASLVGMRETPGMVVVNRSGRRGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNL1</accession>
    <name>A0A2T6ZNL1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1027825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNL1"/>
    <dbReference type="OrthoDB" id="3918840at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="14042" checksum="BE64D466D7F2B8BE" modified="2018-07-18" version="1" fragment="single">MNPPAPAGSFGRVGNELQHQNPWLFQIVLHHLKRNWNPQGWQQEMQPTERANIIIQIVTSLRLVRTDVEQTQAILIATEFERSTYKKSQNRVGWMFFSSLFFSLIPMCLLPLCSPQDEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNR7</accession>
    <name>A0A2T6ZNR7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000162">
        <property type="protein sequence ID" value="PUU77131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNR7"/>
    <dbReference type="OrthoDB" id="5376498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="162" mass="17260" checksum="0E8941D2E4033065" modified="2018-07-18" version="1">MTTIETTPTPKTHTLLLKSHRTTILLYAQDADPLSQIKSQIHAHLSINAANLEALDSGLKIPRSPEEIVLAMPVGGCNSGGGEWVEVEGQDKGICTVASLGVRDCGVLAWRVLGDGEEGGFLVEVAGGEEEEEEEGEGEGEEEEGGNGYARGEDEEDDDELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPF6</accession>
    <name>A0A2T6ZPF6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1115507</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPF6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPF6"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="210" mass="23562" checksum="F20255F46F3DFBF7" modified="2018-07-18" version="1">MSPSSFTHEGLSPPANFAVVGNSGFVYRSSFPKPENFPYLQKLKLKSIITLVSETYPSENNEFMRQNSIKHFQIGMPGNKAPFVNVLDEKISIALRIILDRRNHPILIHCNKGKHRTGCVVGCLRKIQAWSLSLILDEYRHFAGPKSRALDQLRIELYREEACMVSARLWGWVPPSVMPSVMPSSCSIQECDEECTGTIDETVNPPAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPQ6</accession>
    <name>A0A2T6ZPQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1146190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPQ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPQ6"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015618927" evidence="6">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="13289" checksum="E00D601CEC84EEEB" modified="2018-07-18" version="1" fragment="single">NRGSLFVLLSQFFCSTMGHCTRVLETSSTEQNMHAMQILFIGQSITTVVVGILIVFRSVEHALWGSWGVRWLLNARDFGGFVGFVGVFGLYYSLAYVDLSDAIVIPFLPPIVATYGTFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ76</accession>
    <name>A0A2T6ZQ76_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear condensing complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_986313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ76"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ76"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="601"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="954"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1010"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113513" checksum="059054F7CACC21F6" modified="2018-07-18" version="1">MPARVASSRSARTRAPRRRAPAAAEEIPAATSPAPEPSPPPPVTYTPLQDAIATIFQSAQKTTAGHRKLAITMRSIWEQCAAGTGPLGASIGGGRVGEKAFVKEFTGFLNRVLMTKKSEVVGDRCLRFTDLFVRGLLDKGGEDEQMIEEEEAVEETSAIRFVLRFIFYLLPLISSREKTVRYRTTQLLSLLLANALPEFPYDYSTKSNAIFKQLRSELLKRIKDKEAPVRVQAVVGVIKLLEMGVGTDEGDSEDDDEEGDGNVLAVLIEAMQNDPSADVRRTILYHINPTSETLPYLLERTRDTDPATRRSVFTRLLPSLGDFRHLSIGMREKLLRWGLNDRDESVREAARRMFNYRWLEDVDGDVIEILERLDVTCDGPQGGVKELALRGFWEERKDFVEKITFGDEFWEDLTAESAFLARSYNDYCRDLPSAQREAGEIDEKMPEVTKLALHLQKYLNKLVVALEGEDAEAATWEFVAEQLLMIASRMDYGDEIGRRKMFALLRESLAIPELPEGVTKLIVECLAKLSMGEGDFCMLILEVIAEVHDRIADDDDEAGVADESFHSAKSDVSDDDDLEDSITVRAASVKATVKELMINLKCLHIAQCMLENVSGSLKKNTHLVTMLNGLVVPAVRSHEAPVRERGLRCLGLSCLLDKTLAEENLTLFAHCFNKGHEALQIEALHIMSDILVTHGSAIFEGDSCAVEQRTLYRMFAKALKLDEVVEVQATATEVICKLMLAQVIKDEEVLTSFCQLLKVLVIAYFDSATADNQSLRQILTYFLPVYCHSRPENQTRMQKITLNTIHQLLLIRENLGEEEEMVSITTTTSQMVDWTDPRKNVGGGVQAGRSGIGEKIVDPNVHVDLAIDTLERVSSSSCNKEEKKVLCAMLGKLYIPAEATPEKLRELYELVTQAIGDKVATDAPSRNALNKLELLLGKIVNELERDGVTEATGDELAATGDEAEAVAGEATAGEASDDEGDDTIVMTKPPRVDDLASETSRETSAAPSTEAEEQEGEDGDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQH3</accession>
    <name>A0A2T6ZQH3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQH3"/>
    <dbReference type="OrthoDB" id="5477432at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16504" checksum="0A720F00D6FDD87C" modified="2018-07-18" version="1">MLSKLAERDNSDNQEHGSNAMSPGEVLAIVIAALTLLVAMIPLFRCPRFHRGPLSSISSFVKKALGITLPDSVSTAITTTEDSNSAPAPNISIPRPVFIYNDYSNAHFVGTYFDTFIYSHISITRVDGRALQVEESLGPRRPERAVTYPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQQ8</accession>
    <name>A0A2T6ZQQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1085454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000139">
        <property type="protein sequence ID" value="PUU77820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQQ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQQ8"/>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="407" mass="44559" checksum="DC9FBFEC0AB3E6FD" modified="2018-07-18" version="1">MPSGRRHLARPTGGGKDFLLPLALTLTTAAIATIGLYFWPGSDSPWGSPHDSEDEIEAGGRSRKSKQHQYFDRITEEDTDDLIEDARRDELLRKEKSARRQNTGSARHNTSSSSSTMMAGALVVDKIEHAVGKAADLLPGTSGRKKAEALREIKREAEEVSKKQQYVPMPARKKNVAIVVSERKVLLGENSDLDFEEAGLPSSLLSHLPHPLDLTHSVVNILVYSPQLKTHPLSKSSAFRSQKAAEASAGSADKSLRKPSASHFSPTASTFTLAASMLPSECPLEHILPFTQASSIVPLLRTLAPETVYIEEPLTLPSSGGIVSTLLEGGWVGNVVVGLIGDDDQLAQLMDSDDEKIQEEEKTRKGEGKWWGTEVQGSIRGRFGNRVQIVEGWVLIEDWRRRVEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQW4</accession>
    <name>A0A2T6ZQW4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_985178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000137">
        <property type="protein sequence ID" value="PUU77867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQW4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQW4"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="314" mass="35295" checksum="CAC12262B941BB0D" modified="2018-07-18" version="1" fragment="single">WRLNYKIGTGACGTVFLENIQIPGMKGPELWAVKRIPRSLPNFTFERYEAEVKNLQALAGHEWFVSLNSTYQDTHYMYIAMEYIPMGDMSQSFKAGYQWNESDAKVVIKQLLHGLAIMHKEGITHRDLKPENIFLCLPENQSHVLQVKIGDFGTSKRIPPSNTSTYLKTTTGTQGYMAPEVHDTSQPKTNRVDIWSLGCVLYRMVAGKLLFNDPFEVMKYALTTSASLLALDNIGLSIPGVSFLYDILQPIPEDRPSAEDCLKKAWIMSQASELEYSIGNDLYTRLSNISHRAPNVHSFPDIIANLAVGSSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRT9</accession>
    <name>A0A2T6ZRT9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_94607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRT9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12578" checksum="BD4D763BCAEB0FF5" modified="2018-07-18" version="1">MQRILGTGTGECSRCPLFLHRIGRGRGTHRVDLDRTGNVTAAGVHCIFFSFFHFFHFHFPFLFSSLPSSSFSFACLHASFSPFPLLPITLHYPGRNHSDIHTTGTCIQYTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRX8</accession>
    <name>A0A2T6ZRX8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_101972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRX8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="80" mass="9233" checksum="DE057EA502CEDEDF" modified="2018-07-18" version="1">MPSLRFFSLYHVLLHRHRHQPYPSMYPSTVTHPYHPPPSEIQPQPTHIPATPIQRKGRKGNYPLQQVADVSVIKKKGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS34</accession>
    <name>A0A2T6ZS34_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Winged helix-turn helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1127013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS34"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS34"/>
    <dbReference type="OrthoDB" id="3047997at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29905" checksum="B6FDDFF76CCDBCF3" modified="2018-07-18" version="1">MISRGVEISIAGGVEEMNGERQIKEATPNALRVQKFRDKQAAMNISPAVPALAPLVITAMPDQQQPISLHEEIHLDLKRWLRCRMFTAKACRRQLTAFGLAKAIAAYWKESIDEDNIANWSVNNVDSEVQRTIGSRTARRWLHKLGFNYKEYRKGVYNDRHQREDVKAYRDHIFLPRISAYPDEFLLRDENLQEIPKPLHLSSIIQPLILVTQYEYTFNSNNRRHYIWVHPEHQPLHKKGHGQGLYESDFLTPLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS63</accession>
    <name>A0A2T6ZS63_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS63"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="21277" checksum="15C53817049682FB" modified="2018-07-18" version="1">MIETWGKAIGLSINGEEKTSIVFQSQELQMQLVEVIETFFAQAHSRQYQQRIPANKTPVRAFEFSKATTLFYHSQVSRSSGCGSGSESEIRGRAGQKRKRKEKEKTRKKYTYTVIFREPEGAKARIMTREEVIKANKYLDPKVEKADIGPSSFYNTVKEARDRKEKNWSAGTASSKEEVNAEIVVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSH3</accession>
    <name>A0A2T6ZSH3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="13" type="ORF">B9Z19DRAFT_1083970</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSH3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSH3"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="12">
        <location>
            <begin position="142"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="299"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU78450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="455" mass="51112" checksum="AB792076BFE54F28" modified="2018-07-18" version="1">MSNSSSGEMSRLFLPPINRAMRKLDPSFFQKTIPLTAAHVLDGRNIPKVTKECAKDLLRVPRLRSVITQKDDAGEERRLLLMKPEVKHDDLSTVQPKTREFVEQKIIELEPYTLHMKYENWNYEEIMSAILPEDLGEIPCGFTQAGHLAHLNLREHTLPYKHLIATVLLDKNPNISTVVNKIEDVGTGSVYRTFPMELLAGEDNTNVEVRESGCVFRFDFAKVYWNSRLGNEHERIFKQFKPGEAVADVMAGVGPFAIPAAKQRVFVYANDLNPESYKSLVDNIKINKVSQFLTPHNLDGANFIRESIRALLSRSRNTSTNKVSIPTPGRRGQKPPPPPTVIPMPPTFSHFVMNLPASATTFLGAFRGAYRGLEDVITGQEMLPMIHVYTFHKAPVTENAAGDICADISRHLGHEMREGDLVNLENVRLVAPSKTYYCVSFRLPASVAFEDTQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT95</accession>
    <name>A0A2T6ZT95_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of G protein signaling domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1064812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT95"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT95"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="213"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="330"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="497" mass="56627" checksum="07261738BDF80EB9" modified="2018-07-18" version="1">MHQTSSRLLRMTGDDRPYTRDFKDLFSTLMVSLPLCSHRIRFKTYSFTFTSEEAINNLGSLKFSQSNRMPDPKDHTRIVTTTTTTTFSMAKEMARSVCQRFMDARFIELADGKSTTYFPPKGSLWQLTPKGIHVLERFCQRNGIQQDHVIKLLQSPYNTMRLVILERDSVTDRLSQDKTTTEVIFRRFAGVTPNVKANISISDSDSISEYHDGVTGVKLAESRKIYDKVVKNSFTGKCAVDWLLDCCTTVERSETHEILNLFIQYGLIQSVLEDKTYIQSNPKSKDFQPTKNAIYVFTDKGRRVSGWIDGDRLSLQNGGGGDQRETNTTRLTAILNDAALRLLFREFLRETVCEENLSFWLDVEDFKHNFLVIEKTKPDAVRETLAAAYGLYNAFLAPGSPCELNIDHTLRQDMASRMTRAVAKDDNAMYSSLREVAALFDRAQQQVFKLMAGDSVPKFIRTQKYIEVAGDILEDERNGHSGIERSQSRRYNNGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTU0</accession>
    <name>A0A2T6ZTU0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1140920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTU0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTU0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000299">
        <property type="entry name" value="ABC transporter ATP-binding protein/permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001471">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF15">
        <property type="entry name" value="ALPHA-FACTOR-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="830"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="41"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="366"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="650"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="929"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU78918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1182" mass="130076" checksum="C56744DD5331CF99" modified="2018-07-18" version="1">MMAKKPPHDVSRKGHGLARQNSWWSLFGFTRKRNFLALLPALLFSIASGLVIPLMSLLMGRIFGSFAGYSSDKIGSEELLASVSRYRDYLLLLGVAGWFVSGSFFTSWLVFGELQARAAREELFQGVISKDMGWFDTRDGIAGLVSGCQTQINELQSAVSEPLGFTVQASVIASVSLGIALYHSWSLTLVILSGAPIALIILSFLSKRIEPFIEIQNLHMSSSASTVSKSYTAIETVKAFNAQGFELKNFSTALEKAARAYRSQASLVALQIGCIRFITFAMFVQGFWYGGVLVRRGRAEAGTVMTTFWSCLMATQSLEMILPQMMLLQKGMAAGGSLKGLLKRVRSGATPLMAGDTIPETLNGEIKFTNISFAYPSRPSQLALSQVDFSIPARETTFIIGRSGSGKSTIGNLVLKMYEPLSGEITVDGLPLNSLNQEWLRENITVVQQENVLFNETIFRNIAFGGKDYQNVTEDQIRDACRTAMLEDTISELPLSYNTPAGVGGKQLSGGQRQRVALARAVLRDTEILILDEATSNLDYKTRSSVMEAIHKWRKGKTTIIITHDITQIKPENFVYILENGRLAQSGARSSLEGEHGLFRSFLRASSREADDQKEEDTVEISNDIELTELSRFQSPRSRKRSSGYRVLLIFGFIAAMLHGLSTPLFSFSLARLLLSFFDTTNPPSESRKWSLLVLAIAALDGINSYIMHYLLESCGQAWIDYVRVRAFSRVLCQPLTWFDWNKVSSITEHLGKDTEEMRNLLGRFAGYVFVAVVMMVFGKANDATSHIGEIFEETVSNIRTVRALSLEEYFRVKLLRATRAAMAIGIQRAVYAGIGFGLTDSTILFATALIFYSGARLISDGLYNLEEILSVFTLLLFCLANVNAIIGSIPQINNSKDTATRALDLTALSLGSYDELNGTRTPDFTGPLVFRDVTFAYSSRPSIPAIYKLNLTIHPGECVAIVGRSGSGKSTLTSLLQRFYLPLHGTIFLSAVPLSSLDLSTLRSHISLVPQSPVLFNATIHENISYSRGYSRNEVESAARSAGIHEFVDGLPDRYDTYLINSGSALSGGQAQRIVIARALVRACSLLIFDECTSSLDTESARVVHESIKRLVEGERKMTIIIITHSREMMRCADRIVVMSKGGVVEDGRFEELSKGGGELNRLLARGELSNGDSGEGLDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTU6</accession>
    <name>A0A2T6ZTU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_981019</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTU6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTU6"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU78919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="712" mass="78874" checksum="6753FFEAB2B74224" modified="2018-07-18" version="1">MPENSGGAAEKGIMEGGEGEKQAYKSRKNSEAGGTDMVRRILPKLEEGNSPPLDSITPARSAKRRCVSSACIPCRRRKSKCDGASPACSTCLAVYQTECTYDFDGDHRRKGALKRDIEQLKEKNDSLDVIVATIRSASESEVCEIVSHIREHGSLADIARSIKENTAMPDCEVHSGSETDLSDVVEKFRTGDSKHLGVLWSGIPSVDSERVGCNDSRQCSGSWTRVTSDIEFISDLMSLYFTWSHPSYVLFSKSCFLSDMSRGRTKYCSSLLVNAILALACHYSDRKETRETGSLAATADHFFQEAKRILVVEGETPCLTSVQALALMSLREAGCGRNSSGWMYSGRAFRMALDLGLNLPLDWQGFSPTETEVRKITFWGCFTLDKMWSVFLGRVPQLPSTIVGISKPNVFPPIESELWQPYTDHGVPHGTPQSGRVQGVAIYFAEVSEVLGDVLTLLYSPKERVTLQILNATYSRLKEWKAQLPEDMAPKSTSLPSMLLLHLYYHCTIGLLFRPFFGKELTFFGENPREICRQAANDSAKVLALFREGYSLRRTVITSPHIILTMAILMLVDLPSSPAIETTLIQCLKDLRELTSVWAWCASALQGIGKLVERLKVELPEEAWNALSAPPSSPPVREQDVNAVHANYGLMSGNSLQYPKVKVEVARDLAEISENTCDPSWGQLGNEDFQFVESMISFPGQFEDWGCIASEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUW6</accession>
    <name>A0A2T6ZUW6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1082064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUW6"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="153"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="242" mass="26603" checksum="4F9E8B075CD1D531" modified="2018-07-18" version="1">MESSDSVGQPLWERGWETHISRHLLVGYYHPARDVRGYRFFLGARLDAVGRPGVGLEANVPPIDDDFDYMPFPTLPTSESQPSTQTTVTSPFQASKFMPSTATHRAIQPSSASSDSASPSPLSPRNGKRKASVAATSPSTDGLDDLSRVAAEEDKRRRNTAASARFRVKKKQREQALERTAKEMTDRVAQLESKIAQLEMENGWLKNLIMEKNTTTMAPSDSDTSRESSKDGVGTKVKNGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV45</accession>
    <name>A0A2T6ZV45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1082045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV45"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="109" mass="12319" checksum="6EA7FD9731CAFF7C" modified="2018-07-18" version="1">MQWVRYLSLGLWIYSQVEPIAPPCLYKSLSPIRSLVPVGLVSPREDVNISVVISAPLFLHREDENTLKLCRLKSYRYFAPGIPGLGIISIAGRQNISPIYDITLTRLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVE8</accession>
    <name>A0A2T6ZVE8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000091">
        <property type="protein sequence ID" value="PUU79470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVE8"/>
    <dbReference type="OrthoDB" id="5455315at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="12455" checksum="5D51CA176010A5FB" modified="2018-07-18" version="1">MLDFAKAGMHTPVLGQMYYWRVTIHDDKSQNVDVQSKAKVSRLLVCDNTEYEGILAAQSVGIYIRANMHSTKMMRSGSTSCRVIMCLADCKIMDYDIDSEIEVCHVNCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVN6</accession>
    <name>A0A2T6ZVN6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_818981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVN6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14613" checksum="82026BEF21D49D32" modified="2018-07-18" version="1">MMTMTMMMRTVERNASIYPKLEKLQEKGIPFESIKKKRQAHFPRVCNPEREKKARRKNRYIKSSSRSVLLSICASPCRSPGFYHTPLTFVTTNAITTIAIMMRTITPGLKRTMLGQNFPRDSERNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVR2</accession>
    <name>A0A2T6ZVR2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_979106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVR2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVR2"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="619" mass="70361" checksum="EE26D063D8422651" modified="2018-07-18" version="1">MGFDFRDKTEEPLPSGLERERIIVGIDFGTTHSAIAWAQTSSPEEYEVITHWPGQSGKDWGKVPSDICYTTNRPASNSTSGQAPSLHRRFFNCSRKIYRGFEVPPTDPQKLSWIKILLDPSQPRPNFVNPKKTTLPRGKKPVDIVTDYLSALKSYTVQTLERRLGKEVVQKSRVEYVLTVPAVWSDKARQMTMEAAIRAGLGVRAGEDSTGLLRLITEPEGAAEYALRSIQPNSMNVGDCFVVCDAGGGTVDLISYRISSLIPLQLNEVAIGTGALCGAVYLDRRFEDFVSRRIGKDKFDAMDHRARFQMNQFWETYVKREFVDDEGVQRDEEEEEENENKLFWVPVMGVPDNEDKGIRGGFLKLSRREVKEIFEPIVAQVLELISKQVIEVLKSGKGPIAAILLVGGFGSSEYLYQRINRWAADKINVMQPRNAWTAVVRGAIIRGLQGDIAAVQSRLSRRHYGVVHDSKYDESKHDESEKMWHPLRCEWVVKNRIQWYIRRGDVTTEQRKISFPFYRTIAESDLVGDTHQLRTELWVCDERVAPDKRIKGDPVRKLCVMTSEPVPASRFIKHTNEKAETFYRVDYSLDMTVTSGVVVYEMSLEGEKTSVGRVTTKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW70</accession>
    <name>A0A2T6ZW70_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_978556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW70"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="688" mass="76123" checksum="E2F6ED83FE883F9D" modified="2018-07-18" version="1">MESLPPSHKFATGLDMGWGGTEGDDVELLRGNDSVVLRKVENQMGGVEAFLQEMLRRRDVLKGANRKRKPSLSTGETVLSPVASSKLRDYLITQMSDSSDSGEADSPSESISSSDSQTPISSPTFPRESPKPILPEKSVLDLLPECVPHFSQKVLDEITMPMSGWNPSTMTLPPPRPANLESPTNRELLQAYLDISAKRLADTSPSYVDLFRKYIPAMAYDSTGLMEGILALAAIQIGLMRRDPGIAVDAASHYHKSLKSHFKAVADPNSRSEDSLLATSIILGHYEIWNGENVKMGVHMLGGRDIILARGKAAHMTPVGRALYAAFNRMDVATSSITGNPTFMTKDWWTVDPFTRVPISTDSPTLLVADAALSKLCVLCCKLTYLKAWSLKRRRTLWVKSNGSPSLEQKESLQEIIQDRVFKLEEELDMWYAELPSWFSALDTDHPDYNPKDEDINTTLITSITMGSYQHISIALVHGWAIGVRLQLNRISNPDIPVVPPRLGSLCHTLLRIFACLPSSTDACIVAPLFAAGMELRQKCHQEWLLNILQERIDETGFHGLIFLREGLRFTWAKLEGMNKGRFNRIKEGAASKIDGVSENLWAAEGMLGTFEKLALYDSPDMVGKRKNFQGDIDTSNLPEDVVPYEAPKADPTVIVIDSAGSSPVVPPKRIRSDSPEIILVRRNGRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWB7</accession>
    <name>A0A2T6ZWB7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1124753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWB7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWB7"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36840" checksum="9DB036460A1F0217" modified="2018-07-18" version="1">MPPRMPTTKLPSCLSSLRIPPTPKLHFSTTPIILKKTANPRPNDLVKWAKSEKIRIENLEKREERKQERLSSRVDPVLGTDTKFVESFDVQPPPLPPVDWARANNVDPLAGHTEKTHLNHYLTPEDLAEALERSYHLTKPYINNLTESGSADFRDRQTEEGLVSAHKEAHDRAVAAIQRIASLSIGSRSDKMRVQKAKCIDLFGRHVTDRTLPRDPGAPDPAESNKTPRAGPDTGSSEVQIAILTVKIRNLARHLELKGPTDKHNKRNLRLLVHKRQKLLKYLKRKEKGGIRWRNVMEAIGLDDDAVQREVMMFDSLRELVSGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWD2</accession>
    <name>A0A2T6ZWD2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DDE-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWD2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWD2"/>
    <dbReference type="OrthoDB" id="3047997at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="81658" checksum="1ECD243426B423EE" modified="2018-07-18" version="1">MPVSLKRRQHLRAIAQQRLKEFHENDPQTTGISEEDSCDGEGSDTDCDVSDNESDPLEETEIESEDENESGSYRKKVKTLNDLIWDEGAGESMRQSYGLGSRKTLYNHRKNKRELAFAAGTSYNIKAVFQHQIDLGISLAAESEGGREVAAEEIANRPFRQIAMEELPRGGPGEAVIAEEKDKKNLEEATKELGHLLTRKSEQVRRYGGELTGHLLLRHQLVHSFYLIQKKCKAGRRAMALQVANSCGRGYHTARMIIHWERSWREKRIIPAHRIGSNGNQVRSIFEDEDILLAVREYMEKSGEGLTSRKLAEVINCYVKNRAASNSDLSIDGGIDLGVWDIEERINYSLQRTGVENDVDTGSLDIWKRKAIVASTVRRWLCKQGLNWRDVKKEVYVDGYERQDVVEYRKIFIERLEKLWPYIVEFEDDGTMVKKAYPQDCIVGGPGQRPIILVTHDESTFSSNDGRRQAWIGPARHFLRPKGRGQGIMVSDFLLPWSRLSTESLSEEERTNSDRQLPLYATKYLEYGKTEGYWDGKDLVAHVLEVALPMLRKIYPGYQFLFLFDNSSNHGTYADNALRVQSMSLKSGGLSQKLLRRGYMNGDPAQVQEMTYQAIDSHTGTETTLAKVCIALKTYVRIASSISDAKTASLVQSVRIVSNLRGIVEYAHNDESVTLVNRDVYAANVNLKFAAFFMNTFPVGTVKTVKSNHLVVPGIAVAQLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWJ3</accession>
    <name>A0A2T6ZWJ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1022673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000080">
        <property type="protein sequence ID" value="PUU79847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWJ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWJ3"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41632" checksum="2F9BB4D49E62F35E" modified="2018-07-18" version="1">MSTTPPVTRQQAKELGVEPKQKVDSGDQSSTDSDYSKHGENTDDRESQEEQQATAEPKEKAVPSSEMISQGLKDLVREHRKGLENMYGTTEEELNKSLEEPIKRGEEMVRRLISDMECTFEVAKDLTALTLYDLAILIDDSDSMISEEEGQRKKTLIQLIDHITDIYSLANESGVFAMRFMNRSGGKKNWKEKSEKYLSEHKYGGVTRIGTELKKKILDKFAIGNSNQRKPLLVLIITDGAVEGEKKGHLKNVIRDCVNERKGAGKGFEAVTFQFSRIGDDPGAAQLLIDLDQDPDLGDYIDVLPVEFDLKHQLEEDKWFVLPKILLGAILPKWDEQDYYNYIRGEDHLAKKKKAAEDADSGSDWEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWL4</accession>
    <name>A0A2T6ZWL4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clr5 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1080599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWL4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWL4"/>
    <dbReference type="OrthoDB" id="4115389at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="23210" checksum="5A1C28DB7F13F080" modified="2018-07-18" version="1">MTKAWDREKSRMHELYMVRNMKLSQMQEIMQKQHNFTASERAYKQKFKEWKWFKKTPRNQGVNSNAMISITRTSPASRSYGHASADLRRCSDSSSLNSVDHHHGQMSPPTPYADPTVSPEHNVYSATQHSLLHLGTVQGPQPIVGEYQISLPPVSELFHYKETVNDSLRSARVHLDSGDLVAAGDHLEYGLKTLRWLTSKTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWN1</accession>
    <name>A0A2T6ZWN1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_977119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWN1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWN1"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="678"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="867" mass="94490" checksum="DF2380AA8802D0E0" modified="2018-07-18" version="1">MAGPQPRKYLTRARAKAEANPIESKQQGKAQRTSEKRKALAEAASSNELELPIRATRASKKTVKMENPAPQPARGVKAAPKRKSEKTASTTAKKPTAPAAKVPKKVAFVASPQKFLEDKENLIPVQKEGHFDTDELISTSMGALSVKPIRVSATKLRLPTVTPSTVILDPIPALSPSKARRAPIKGLELPDDGSEDELSSPHYPKLTAKPKRVGGTATRHVGIDPNENKPLDISASLISSPARRPPAPTKANLSTKILEPSGLSSSVLASPARRPVPGSIPGFRASPIKGSFKLEPLTTLSAIDHQPPSKLGIQNLPKRVKVANYVKVDGDQDELGMDMETNLLSCKTPRVVKIKLFDPKDSEQAMMFQSEDSSALFDEIMSPTKKEPRSLEAKSLDKMLEEIESERKAVFSMTMAKASTNPPTPPGFDFEDSFGSGNKSPAPLHENAPELQRPLEREIDFEGDITMEDSEDNTETILKKELSLTPSRAPPCNRKHRSPSQGGSSYGFFDLMGDEDELLGGNTKMFFPPDGPPCSPIVKTVSSINLTMQPEPERRTLFPDAQPSQGSEVGHDLDWDPSKPNNTSMDNIFGIPIDPELLLTQEEFLGIVESHVRKTTIPVNLPPEDSEDEGSDMEIEDQENFHPSPYPSNIQRDPSPTVRGSPPAASNHFARRNSGMVSQMGVLAGAVVFVDVYTAEGADASGPYEDALRGLGARVLKSWNWNPDGGNKDKIGITHVVFKEGSPRTLQKVKDSKGVVVCVGVGWVIQCQNEQEWMDESQFAVDLDTIPRGGHRRRKSMEPKALAALSEPKTPQAPKSNAFSLSSRVPAQTEPRNPFLAKNLLIARRKSMQFLPKVGSPLSRKPLSVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWS0</accession>
    <name>A0A2T6ZWS0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1063809</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWS0"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="200"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="846"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="651"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="923" mass="101176" checksum="CC308BFEDE325CAD" modified="2018-07-18" version="1">MEPYVGSEKENTPISKTTMSMVTVRLSDTTLGSLPSPTPTLKLVDDNAEEFPLNNNDDPMYALERTESSPDGMAASRRSSTESITSQGAVDWEGLERTEGESIKDETSEEGTAFLLARLEQENKRLEKDPKALHIHPERPPSLAQLKRMMNKPDPETLRYSMLPTPPPLTDLEFYAALVADYNRAASKLPHLLSKKIRGGIPPPLRGVVWIAMSGARDSSLEGLYDQLLGETSPYEHLIGKDIGRTGLEMFKQEGGEGQRMLGRVLRAFSIYDTQIGYCQGFVQPSPRAPAVSNYCSLGFLVGPLLMHMGEKEAFCVLVRLMEHYDLRSCFLPNMYGLQLRMYQFTQLLAIHLPELSAHLNSLGIQPTYASQWFLSFFAVSCPLPMLFRVYDVIFAEGAPETIMRVALSLMRRNEKRLLATSEFEDVMQMLLARGLWDTYNFNANDLVQDFVGLTGIVTSQGLADLEKKFREEHPDDNGTKTIPTKTPGSDLQAAASRFLGRMWGGGTSPGPVSLSPASGQSRPASILMRRTPSKQSLSTVSSFDTSDTGSGTTDATTLSRCSSVAADDRRISTRSISSTRRQNKDGELHGQIEDLLMALSALQREHAAKVDELQTVKAEREEERMLAKRLVELLANGSPDGDEPESVDSIAEISDLCDQISENLTRAESETVITPKPSTTQLEEELQRAREQIHREQLKSRDLANKLAEQDADVVRLKSQLIDARSKWQESQREKQQLQKTINELKHPLSSPEPKDRDAEPQKGGLRELRLGRSNSTRGQPTPTFNKRSSSLGMQSILAQDNNAPATADALLLELVASKTAEAVAKQEAEEAKAKLEALRKVLGGGTSSSASSFRDPPLSPGLDRTASGGSFSSYLSVGSPAPATPSSATSSGGGSGEDGGRSLQPSIHDSYALHLISICTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWU1</accession>
    <name>A0A2T6ZWU1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1192199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWU1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWU1"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU79949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="600" mass="66889" checksum="27D9C4D86DA0136C" modified="2018-07-18" version="1">MAEVRSRSPARVKGAGGGYPTSSSPEKISISESNAEKLVGPRVSHPIISPTSAFSILLVVRLLSAVYATIPDCDEVFNYWEPAHYLTHGYGLQTWEYSPVYAIRSWAYVGLHAIVTRAVSLAPQLEKTHEFYGLRCLFAVFCAYSEKRLYTAVSTGVNRRVGILYLVLTIGSAGMFHAAVAFLPSTFAMYTTMLGMASFMDRRRGFCTVQGIFWFAVGGLLGWPFSMAMCIPFVFEEIFMGCIAWGLAPTVLRLVKGGLVSLILLVLIVGVDYLAYGKLEIVPLNIVLYNVFSGAGKGPNIYGTEPWWFYFANLTLNFNILLPLALASWPLLSLYYLACRSLAIGITPRMALISLPLYLWLAIFTAQPHKEERFMFVAYPALCISAAISYHVILTIWGSLSTRLTSGKAREFLNWAVLAAPLSLAMMASISRILAVTSGYSAPLHVYSALPSDAQGYLCLAKEWYQFPSSYFLPNGMRVKFVKSAFDGLLPGEFPETGDPWSWPGTWMIPSGMNDENKGDLSKYVSLELCDYMVESYFSRPVEEFEPDYALDQGQWESVYCENFLDSAQTGLLGRTLWVPRWVPVKKSWGKYCLLKRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX08</accession>
    <name>A0A2T6ZX08_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B9Z19DRAFT_1100559</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX08"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="23">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PUU79974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="152" mass="17303" checksum="C08D31F99A131EC4" modified="2018-07-18" version="1">MSTSARRRLMRDFKRMQTDPPAGVSASPISDNVMTWNAVIIGPVDTPFEDGTFRLVMHFEEQYPNKPPSVKFISQMFHPNVYATGELCLDILQNRWSPTYDVAAILTSIQSLLNDPNTSSPANVEASNLYKDNKREYVKRVRETVEKSWEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXE1</accession>
    <name>A0A2T6ZXE1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1124065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXE1"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03775">
        <property type="entry name" value="MATH_Ubp21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="73"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="227"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU80140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1159" mass="133403" checksum="4CCD4D3866C7204E" modified="2018-07-18" version="1">MGITKEQPDDQAMVIDGLDQDNGKTQDVTIISPQQSIDSGSADDKDSIMLADDYEAMKKSLLPDIPDLETEDETTYTWKIENWRRMERRSHGPVFHCGGSPWRVLFFPQGNNCDFTSFYLEQGFDEKPPENWYKCVQFGLVLWNPNDPSVHVTHQAHHRFTADEGDWGFTKFAELRSLMCTTKERARPLVEDESANLTAYVRAVKDPTGVLWHNFLNYDSKKETGYVGLKNQGATCYLNSLLQSLYFTNSFRKAVYQIPTENEPLSNSALTLQRLFYLLQTSNEAVGTYELTRSFGWETQDIFAQQDVQELNRILMESLEQKMKGTQAENSLTKLFVGKTKTYIKCINVDYTSERIEDFWDIQLNVRGFKNLDESFKDYIAVETMDGENKYFAEGHGLQDAKKGVIFESFPEVLHLHLKRFEYDLNTYAMQKVNDHYEFPEEFDAAPYLSEDADKSEPYTYALHGVLVHSGDLNAGHYYAFLRPEKDGKFLKFDDDRVTKATLRETMDENFGGDYGPATTNGLPRNPQARAISIKKSMNAYMLVYLRKNKIDEILPPVTEEDTPAHLQKKLDEERATRELRKRERDEQHLYLNVKVITESQFKAHQGFDLTSWDDKDQPEEAQPRHYRVLKASLVKDLVEKVAADIRVDPSNVRLWIMVNRQNKTVRPDQPLTIPEMSMALNSYFEIQSSNARTLGIEDASNKHNNKSSDFRLWAEVATETKPGKNLEPWAQARDSNSAWIVVFLKRYDPESQTLRGVGHLYMRKNDKVAELIPAILTEMNWPPGTPLKLYEEIKPQMIEPMKPKQTFHQAEIQDGDIICFQKAYTEKEAVALFQKSLMPDAKDFYDLLVNRIVIKFHPKSPNVAEGKVFDLTLNKKMTYDQLADQVGQHLDAPPTHLRFTTINSGTGGARAIIKRNPNTTLHQMLTTTYYSNTTISPNSLFYEVLELSLTELETMKTLKLYWLPEGIVKEEQVEILVPKNGQVQDIAAMLQKKLELDDETASKLRFYESHMGKFYKELEPAFNVAGIQEYMSLLVERKPNEELEMEEGDRFIHAFHFHKEPSKAHAFGIPFKFVVKQGEIFEKTKERLQLRTGIKGKPFEKIKFAVVRKTNTPKPIYLSDEDILADVASESDDVLGLDHVDKNSRTWGRSGGPEIRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXM2</accession>
    <name>A0A2T6ZXM2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1191975</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXM2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXM2"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="224"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="690" mass="79033" checksum="59DA49BD53CB5BE9" modified="2018-07-18" version="1">MATGYPKPPPAPKFTHTPESVIEETNRLITTSRKLQDQIAKDVTLETASFENVLKPLAEDENEMGLDTAILGFYQYVSTDKKLRDASSEAERLLDDFGIESSMREDIYKLVSAIHKSPQSKAVDVDAESSRFLEKTYEAYVRNGLGLAEKERARFKEIKKELSILGIDFSKRLNEENGGIWFTPEELAGVPEDVLSGLAKGEPDSENKGKLRLTFKYPDLFPTMKYATNPETRKKVFLGNENKCNENSKLFKKAIDLRDEKARLLGFKNHAEFILQPKMAKNPEKVLAFLTDLRQKLTPGGEKEKSRLKQLKAADTKDKGITDDRHYYLWDHRYYDRLLLEKEYKLDAQKIAEYFPLAHTIQGMMKIFESLFGLEFIEVTDETKNTWHEDCKQFRVYNEKPKDGSEQTFVGWLYLDLHPREGKYGHAANFNLQPGFTGKKGERHYPATALVCNFSKPTATKPSLLKHDEVVTLFHELGHGIHDLVSITYYSRFHGTNVVRDFVEAPSQMLENWCWTQSELTSLSSHYKTGDKIPLGMVKTIINTKHVNDALFNLRQLHFAFFDMEMHSYKSHDDAVKSEPSVRYNKLRTEIALLDPPGGGDDFGHGEATFGHLMGGYDAGYYGYLWSQVFSTDMFYTAFKKAPMDGEQGRRYRHTVLEKGGSRDEMETLKEFLGREPNSDAFFEDLGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXW0</accession>
    <name>A0A2T6ZXW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_736734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXW0"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="20030" checksum="47C0065CDC728B70" modified="2018-07-18" version="1">MDTPQMVNSPATPSHRTNGRPKRQAQKPQTTAASVCPQHPFIRTTDLANPHTVPPIFTDPSLALSREVRIPTRTLTTTMAASPASLEEWRNRLFHVTEVMTLTEQDFLQPRILTGTDGSHIGLTLTISGLIDPRKNPRKDLSKRITMIAVLKGGHREHHRIKIQIKRSANGLQGKEICAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXY3</accession>
    <name>A0A2T6ZXY3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1079547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXY3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXY3"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="243"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="391" mass="43411" checksum="0FD64AD13326EB7D" modified="2018-07-18" version="1">MKIKVVETIVEDGSGVGKTFTIERVRKEGLPQRARIGDPADVGGEGSAADGQVLEQQLEDVMGLGMGDELQLNDPGAGDGPHSLGILAPNKAVDMDQYGIPGLLGEVHRHTLEESDRIKKCTVEREGIKRQKEMKKVQKTYHKKASGQALQTVKRHSKPNELKLFGSCFCPFVQRVWIALEVKGLNYQYIEVDPYKKPQSLLEINPRGLVPALKHGDWGCYESTVLLEYLEDLEVGTALLPQHPQLKATSRLWVDHVNRNIVPGFYRYLQAQEQGKQAEYGEELRVEISKIVDAADAGGPFFLGPYITFVDVSIAPWLLRLSRVLHPYRGWPVAEPGSRLGLWVNALESSEAVKNTVSSADLYLDSYERYAENRPDTSQVAKAVNSGRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYP8</accession>
    <name>A0A2T6ZYP8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1100178</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYP8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYP8"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="227"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="361"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="452"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="736" mass="77929" checksum="D224493C2BDE2E33" modified="2018-07-18" version="1">MSMPGGFSTDSVNHPNRRRINMPSINTGAPHGGDNGMASPGTGYDMQFTPLLPSQLLLGSPFQPGTPNAFASPNFPMHGFQQTPTSGNPLSPTFGANGLGSPTGFNPQYATYYQQSSPTATSPLAATPGMIAGTSRTVYLGNIPPETSAEEILGHVRSGQIESVRLLPDKNCAFISFLDSSSANHFHSDAILKKLSIRGQDVKVGWGKPSQVPTSVALAVQQSGASRNVYLGNLPEDVTEEELREDLGKFGPIDTVKIVREKAIGFVHFLSIGNAIKAVSQLPQEAKWQSPRRVYYGKDRCAYVSKTQQQNAAQYLGIAPGYAHVLNGADREMISSALAQQSVAAAAVATSAGGMNNLGNRTVYLGNIHPETTIEEICNVVRGGLLHHIRYIPDKHICFVTFIDPTAAASFYALSNLQGLMIHNRRLKIGWGKHSGALPPAIALAVSGGASRNVYVGNLDESWSEERLRQDFSEYGEIELVNALREKSCAFVNFTNIANAIKAIEAVRGREEYKRFKINFGKDRCGNPPRQTTNNHQSGTPTSAGHPPLPSTSPVNGPPSGGLQPSLSQSGSGGSPAQLSPSGMHNSNSPNNVGTPTTPNVQHMLNNNAAANPLQAYLAQQHQQQEAAMYASSLQQQLAAAQAAAVYGPPSGSQLDPAGQAATAAVDGLGQNHNGVNGLGLAGMSIQNQNLRVGGQHNRALSMPVLGQQNQIGLGVNGYNGMGNGIGWAEEDVNMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYX2</accession>
    <name>A0A2T6ZYX2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1078786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYX2"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="693"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="918" mass="102989" checksum="2DC3198D2C9FBE5C" modified="2018-07-18" version="1">MAKAVQSSNAAASPAMGLVQAEFMSPEHVELLEKFKTDSAKLGKEFQATSRRLAEEFARKLKNLAPFNEESPCSTSSSSEHAGSDSERLEEPDDDDNDDEESLSPSADSTSPFVELGVPKPKPQVNGDSLKNSTKLESKERKKKKMLTVNGISKTDTSESPAAVGLDLSQKVGEMVLGGAIMVNGDGESTDRKERIRSSKLDYKRLDELYNKTTHDFYFAESSQSPAGKEDKWEEYLFVIRRRFDWQNKYQKTYVDIKSIEIRTVLREILKDVSGIGLREDKPTVEPNLLFNYLPQLEIELTKARDVPEEQQNKTLISHLTLFNEYISTDYASTIKRLYPLLEHHEITFDLLWALFLPNTLIYTICAGSNEPRCLKLDWGEQKETLDRGKFFQLDCHYVDYDGKTYGEASAVLEIDEFRGARRIDSLGVFPLAYHEDEEDVRERLIERGRKFGSLKGMHYKYYKGLAFFKRKRGVVRVNVNGRIMVDPSTFRRINPNYRMSPVKESSSHSSSGAANAEDDSENENEDEDEDCGGGDDDEDGEINSPNNMVKPKASVVAAAVKRAIGTKPQRSYILGPDGKIKLVGTTPGATKKKLLETGKTAERIKDALVPEEMTEEQLLLCSPTVLGFSFGDKLWAEFAVEHVNEIKFNPDAFESLVLPKAQKKIVKALVESHTSNRGSRPGIDDVIKGKGKGLVAVLHGRPGVGKTLTAEGISEFLQKPLYMVGAGELGTDSRTLETQLSRILDIAHVWGAVLLLDEADVFLERRSVHDLQRNALVSIFLRLLEYFQGILFLTTNRVETFDEAFQSRIHIALRYNDLDKKARRVIWKTFLGMVAREESGSDCQLRDIVSDEELEGLARRELNGRQIKNAVRTAQALALNKNEGLSMEHLKLVLAVTEGFEQDLKGTGNLDSMMSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ28</accession>
    <name>A0A2T6ZZ28_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ28"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="131"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="365" mass="40583" checksum="80A4FE9B222790C6" modified="2018-07-18" version="1">MNSPPTMNYSTTPLHQAIVYCTSLELARTIYDTEYCMTREHQQELADYPPADTHECAQVIDAWVTRLKIIKSALLNFPTTSGSVTINSSPGMITVGWVAGNTAHPVTAHGQHNGRSRAAETDCLKRDNHQCIITGRTPQDGSTIEVAHIIPFDLANNPHCRDLDFWKMLDIFQGKEATDTMFAEAIDKINGLENLICLDSTIHSMFRDGRIILTPVTHNGDRIHIKSNHIGDYWLRVEYPLELGMAEFIQSTKGLSAGEVRTLYWGNGVPLTNHNRMPGHPRTLPLPSFFALRASIHSLKHESEYIPTVRDLQSYADARFTTPIDTENLQSMHRATSHTTSADPVLAASAILDDLVDSGDLARSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0B0</accession>
    <name>A0A2T7A0B0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1020245</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0B0"/>
    <dbReference type="STRING" id="42251.A0A2T7A0B0"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU81188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="363" mass="40464" checksum="98270F4DC8A564DC" modified="2018-07-18" version="1">MAETFEPLSNDLILRAARGEPVERPPIWVMRQAGRYLPEYNQAKGGRDFFSVCRDPELASTITLQPILRYANLIDAAIIFSDILVIPQAMGMTVEMLEAKGPHFPNPLRKPEDLSQLKSEVDVRAELAYVFDAIRLTRRKLAGRVPLIGFVGAPWTLMSYMVEGGGSKTFMFVKTWIFKHPSTTHSLLARITDVCVEFLAHQVLAGAQMLQVFDSWAGELSPHDFRTFALPYIRRISARVPVRIKELGGEPVPMTIFAKGAWYALDELCESGYQVVGLDWTHDPESAVAVANGRVTLQGNMDPNVLYGGREAITQAVERIAKGFGGGRKGWIVNLGHGITPFVDPEDLKWFFEETRRVTGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0S5</accession>
    <name>A0A2T7A0S5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1077290</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A0S5"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="1371"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="1647"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU81338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1929" mass="216788" checksum="43032BA6EB7C6C8C" modified="2018-07-18" version="1">MDRPSRALRRIALERLASLSAKEPQPAASSGSSSNQKNSDLDRLAEGCVAYRPTLNGVLAGNGSLNGTGTPPTQTETSQIPISLREFEVLLALCNAAPLLQTHESAERLRRQLSPYLVESSSQKLSPSPFFRDIEPSPWECLTSHLTSALLSLGLKFPSLRERIIDTIHTYLDNAVASSTTELDEDDALAFAPPVLSFLGFLDSCAKHINFWFPDERVSLISQIRDVLSENYLSNVEAVFAAVRNSDSQEAYLKPWKAHVRRYSTAGKPLGAMLIQREYMKLVAAATSLMVVEEPVLQGQEILDTIMSDREVSANTEEDPSTIEFFVEVASEGIAVIEEGVEYARSEWQQQLGFSMKALALVTYSNCLFLNENIADLEQLLKWLAATMSDGAQMSHEELASTVLKLLSILSNNDPQSTPNFVSTLHKFIVEGSGPTNQTTVRVAGKCLAYVLKFLPQDVTITTLNTLGHVLSSSNPERALKAERLQPFDQLTMGSSLSLTSSGEEDRQYVYSSIIETIVKIVDSCKDDKMVSLGQHILVQRLNKVNTAVNAKILTGLASLALKSSPTDFKSVLQVYNKMGTDAVWQDDVSIVRAIFDARMTLAASLTRQSQLCDIYLNDMLEFVAAIGNPREHEEKRQTDALLAAREIHQFIPPLAKLLSNNGPEVNFAIRYGFASLLRDFWFNCALNGILYDSEEAKKYILDLRTIALYTPPLVSGMEEDESIDNDLSEQSVLARSASPQNTVEHKKRLLALIPSEEIGIRPLSHPRAIFLEAAYTLESFRAEAGGCSKVLAYFMEVGFKAGTSTSCMIAVASSAMDTYIRRVQEGIYPEFSAMRAAEELADIFVGCCHRLERIQTTAIGIADRMIDVMPSALCQKTSLFALLELLTLLWLSCLEEETDEYTTRSIFTSVKGGVSVELPDSYIFRRKLLKVFQTKAKAWVLQVLNVAPLDVKGLMQTYLSEFEDEGSLGHVSLGRSFAVEIGSAVPSGDQRLASIEHRRDCDGNVASDFVMQYTTRQAYRYTEPALEYHQDWLSIRPLGDSANSSNAPSIMRPDSAQALLSQMESKDYENEFVPIGELRDMLKRAAALVCRSEKDQGALIRGLVGIPFAVFSKKSINLGISLWTGVIHEKPRLQSRILTEIARNWEMTVEKKMGLFSDNFTSRDPFELKMEYAPPDKEQHLMEQQNASDLLSPHLKLLHMLSSHYHANRNGNPHIQKIFLRLVRVSLVGLHHATSHPLSREVRFKLVLFGLQVLEYSTGLNERQQLRLKDQILSAALTWFKFPPRWSFGGNRLQVKAEAHLLQDVANLLQSIATISNTTKNIREKHDLLLMLVENELTRLATWLYPLDHSRKHHLLPSHPARPTTDNSIAVVLPTAWYEDPAIAVQLIKRFQSPRLEQDIKRLIMTYPEAVVDQPDALQIMLGDKISSQLSFQLKYLLYWAPVNPITATTYFLPSYANNAFILQYAMRALESHSIDVTFFYVPQIVQTLRYDTLGYVERFILETAKFSQLFAHQIIWNMKANAYKDEDSQIPDPIKPTLDKVMDHLIGSFSGADKSFYEREFSFFNEVTSISGKLRPYIKKSKPEKNQKIAEELAKIKVDVGVYLPSNPDGVVIDIDRKSGKSLQSHAKAPFMATFRISKKDITNLPKTENMSRSERRRDSVSTVTKELWQSAIFKVGDDCRQDMLALQLISTFRNIFNSVGLDVWVFPYRVTATAPGCGVIDVLPNSISRDMLGRDHEMGLYDYFINKYGGEDSIKFQEARNNFVKSMAAYSVISYLLKFKDRHNGNIMINDAGHIIHIDFGFCFDIAPGGITFERAPFKLTAEMISVMGGNTESQSYLRFEELCVKSFLACRTYVDKLTHCVVLMLDSGLPCFKPETVQNFKDRFVLDKNEREAADYMRYLVKKSYGSYSTAQYDRFQHLTNGIPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0U8</accession>
    <name>A0A2T7A0U8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_627147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0U8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015606199" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16517" checksum="77BD724404D671F3" modified="2018-07-18" version="1">MQLGSLLLPLLPLLKNAEALFGLMFTWLPVYPSLSTDSKPYSLAVRYGTLPMPVCLARLPVMVGQHRHQPEGRYCGSPRGTRAARRVGKTFPLSTASILAHPIVWEEEKSAQRTGAFEANEMLYRMNPVMIGTTITNNNKQRKSSVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A162</accession>
    <name>A0A2T7A162_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1122095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A162"/>
    <dbReference type="STRING" id="42251.A0A2T7A162"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="482"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="565"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="827" mass="92520" checksum="8137A9E7D7B23BFB" modified="2018-07-18" version="1">MNSQSSAYHPPRCHTPDTEDEFEEPPLGMQSPGSGMLPPGRPQMPDNQPIPGNPQLPGFSQVIDHIPIFGNPQVPGNPQTPGNPHFPHNPQIPGNQQIPGLQQITGNSQMTLYPQMASNLQMSGYPQMPSYPQMSGNTQMAGNPQAPGTPQVHSNTQMASTPQMTYPQVPSNLQMPGYPQFPGYPQMPGYNQMPGYPLVPSYPHPELHLYPSVQHQIYGSALLPDNSTPSCPHTTSLNPNVQSPGMGKQATPPTANAGSLPTTPPKVSPGTEIIIALLGVTGAGKSHFIREVSGNLAVEVSSDLYPCTNKVQSYSFEYAGARITLVDTPGFNGMNRSDTKVLRMIGDWASEAYRNERLLSGIIYLHPITHTRMEGSILKNLRTLQGLCGQEALENVLLTTTQWSRVNWVEGEFRENRLRIREFWGGFIEKGATLQRFAGTRASGLELIHRLMLNKRKPLHIQNQMVKQHMTLLETDAGKCINELLVEQKKKHKEEVESLSLEHQEAIKAKEDQMNETLAAEQAKTQKKLEEAVTEKELLAESHAAEVKQREAEERERQEEAAAYTKSLEEQLVVEIQKRQEEERKRQEETAAKTKLLAELQAAEINKREAERRKRQEEAVAEAKLLAELQAAEINKREAERRRQEEAAAEAKLLAELQAAEIKKREVEERERQEEAVAKTKLLVEQLVAEIKRREAEEREERERREEIWRGEKAVIAVATKDLTNAVHLDTFRGSYSTRGRWILDINNHKEFELNTFAVEIQSPQFNTSSGSWAPVKTLLGLGTKGTGTKGAGSTDYIFSRGAHYVFQSGTSIRRGGQDFFIFMKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1I8</accession>
    <name>A0A2T7A1I8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1165623</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1I8"/>
    <dbReference type="STRING" id="42251.A0A2T7A1I8"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="42"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="490"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU81594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="614" mass="69783" checksum="E1D4A0D1D801DB1E" modified="2018-07-18" version="1">MQIEQVPQDEDAARWAEAIKARRASKRRKQEEDEEDDKVVVGTKVDHNHVNWVTAYNMLTGIRFVVSRVNAKMDRPLTDADFDAKHKFSFDITGNELTPSAKYDFKFKDYSPWVFRQLRTKFGLDPADYLMSLTSKYILSELGSPGKSGSFFYFSRDYKYIIKTIHHGEHLFLRKILRDYWKHVEDNPDTLISQFYGLHRVKTPFGRKIHFVVMNNLFPPHRDIHQTFDLKGSTIGRDFKEEHLEDNPRATLKDLNWLRRDMNLNFGPNKKELFLQQVERDVKLLQKLHIMDYSLLLGIHDLTRGNRDDIRNNALKVFQPGGSENDELHGHMLQRTPSKLEKARQARELRKIINKEVPVSLDRTSNRLPDEFLEQRKTAFYGDDGGFRATHENDEPGDVIYYLGIIDCLTHYGFTKKAEHFWRGLSNPKDQVSAIPPQGYGDRFFKFISGLVKSPEQAARDREIHGKVNAEAAPAQSENDVVTGVRNQAERVGVNEGDRPTRNLGTVRSSAERTGGVLPVVEEAGEGGSTGAGSRSRNGSVSNGGRHSGYFGGVPDRRPSREIASSSSPPASGKPRQQLDNGTALHQSLNLQTGSIVQKHEQDDFAIRVARVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2N7</accession>
    <name>A0A2T7A2N7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RSE1/DDB1/CPSF1 first beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_513063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2N7"/>
    <dbReference type="STRING" id="42251.A0A2T7A2N7"/>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="1">
        <location>
            <begin position="56"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="28293" checksum="4AF359E40BA00C29" modified="2018-07-18" version="1">MEGLNSHTWVNGQLRTEATQQEQFMAQNFNNDALSHSSEGPPGYGLMSRTLVHSPVIKQIIPARIRSRGLNDVAFIGETFIELHLLTDDGKLRQVGSKTNFQANIRHARVFGSPRKNFHSAQDAIFKQELATQSQEDMAMRGVAEGGVNGGMLPGAEGDDSKPLLPPHILVLTLDSGHLAFVYAKSSEEQGEVNFVVSMKRIDQKGIRMEGLGKSIAIEGVGCGCVSGLIPNVCSPSYRGAGTPIAGRAPSKPYQGREIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2X9</accession>
    <name>A0A2T7A2X9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1041831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2X9"/>
    <dbReference type="OrthoDB" id="14384at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="49" mass="5740" checksum="D333F0AF848DE99E" modified="2018-07-18" version="1">MEQKERMWGLQEECVLRGREGLRIVQRNAWVMRIVLLGRKTGAAMRVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A326</accession>
    <name>A0A2T7A326_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_505272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A326"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="136" mass="15410" checksum="A26C5EB0AC9C6EA4" modified="2018-07-18" version="1">MVAWVVPVANVTIHPSIIHPPYCSLPSWNNPLPCPWHCARYNGQGESKFADKQRLLIATMGVMPWSASLGASPFLLALPPSRSLFLHFFFPHPLCTSLSRQRLTLFTFFFFFALCPVTPSNPKNNNFSWDFFYSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3D4</accession>
    <name>A0A2T7A3D4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1121107</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3D4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3D4"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="380"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="460" mass="52203" checksum="AEDC8299489923D5" modified="2018-07-18" version="1">MSGNIRGFGYLESLPPVTFRRLYQQPATALAIFRRMLPNLAKTIVTTLLYNETPVALGDLEALVRPESYREREDAFSKLRRLHIITENNLDVSLDPVFKKNFRGDHHSFGVPCNTEDKKKITVQFLDNYATRQFEAILHYMVGTHNEVKPSEGVITLLTKGGLMERYGAGSQATITKNGFSFLLQDGNPQVWALLIQYLEMAEELGMEQTDVLHFLLMLGSLELGQAYSVNTLTETQKLMLADLRDYGIVYQRKSSSDRFYPTRLATTLTSESGGLRSASASMSSAMVKDAEEGKGFIILETNYRVYAYTNSPLQIAVLNLFVKLSTRYPNLVSGRISRRSIQEAIKMGITADQVIDYLSSHAHPQMRKSLVTLPPTVVDQIRLWQIEGERMKTTTGFLFKDFHSTQEFEEVAKYAEELGVLKWKKSARRCMFVTRHEQIADWLKRRASAQQQQPKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A424</accession>
    <name>A0A2T7A424_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1074523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A424"/>
    <dbReference type="STRING" id="42251.A0A2T7A424"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45386" checksum="7EDC262803EB3DBA" modified="2018-07-18" version="1">MWVFLRTLSLHLQICWQVIPGRRFFLTAQAAGWSIPVVFLAIALSITGVSFRFGESCHINSKSGLQTFWGPLLAVAAASIVTQSITFGYCIQVYLRSLMEEKEATELRSPLPYATSVRTVTAGQAFRRIQRVVALQWRGVFVVVLILANVVFFATVFLQFDGTTEQTPENAKIGFRWLLCLLQHNGDKDKCLDVAAELVVPEATALAVLFMLSFNGIWALVLLGNFSILVGWYKFFKNVLVRKKPNDEFVSFNARRLSEPDPPYEMLDSLKAGQPPSTPGSFRPAVLKSGQDASLSLSIPREYNPNTFSAQLRERADSDACGNSSRLRSESSFSSPPYTPFKDIEAAGRTPLAPYSPYKELDSAGRSPSLKGGQYSPYRDLRGDDKSQAPDYISPQTPQYPPDAKIGVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4C3</accession>
    <name>A0A2T7A4C3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4C3"/>
    <dbReference type="STRING" id="42251.A0A2T7A4C3"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="480" mass="52733" checksum="262BDB4D88B25663" modified="2018-07-18" version="1">MSSTQLNKAKDKMIGTSNPRQNPPPSTDIPMADPAIPVVRAGSAMGNTDAPPHNIHHSTEDSTGPGSRPSGPQHPLPPLSRRGAYRVYPNRAGDSSLGQATPPLGAHAASGVLSSSSPGPKEAGKAFKPGVQKTYKPDEEVVRKGVFGSSGDTGGLRGTESLGGTSKDTRVNRSEREGAVRSRTVLETDLRKVKSGLHNRTSEKDLHMRHDAPTSETQDLQKQVEKLKLAVQKANVALQTERQLAASNEQALRGEWEDDRNALNDELGQLKREVQGKESRAVSDRNTEKQVSSLLTQQTNLDARLIDYEKICHERDKYWGERNDQLHEKNVRQSVKIALLEERLKMETLAKLRLQENFNIRGGLERIVYEGRLEGMIGVGCPRGAKAGLEAITKLPSFQDALDREVSERALVKTDVLYCISGAYQKYSEAAHGNNGHLIIRHEDHSDNQVAALVVLLKVQEAWKNPLRWTEVPLPGPMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4E1</accession>
    <name>A0A2T7A4E1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4E1"/>
    <dbReference type="OrthoDB" id="5363415at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="220" mass="24831" checksum="A3C94D3B96616E7E" modified="2018-07-18" version="1">MAVNHDLTRILQILAASTQAAQVAPQPLPPARSDEEDDSYSPPPAITPDPRQTYPPPSIHVPEEALDPSKIEEWNAALRYVMRELYKNEAIMAGIKKVGYIGMINSQHEHEKAWFHAREEIVNKHKARKESGKKVEDVLRKLGTFPLAQQAIVHPTAESEAEELAVFDRKVYTRSEQMVAHMTKEFGSMGIPFFCHPNSAGPGMLDRKRRMVELLQDLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Q5</accession>
    <name>A0A2T7A4Q5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1074330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Q5"/>
    <dbReference type="STRING" id="42251.A0A2T7A4Q5"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="33090" checksum="F8BC08760DE6E943" modified="2018-07-18" version="1">MSDHLDQLYLTYLDTIDTYQSLRTSLAAHFSTGFLTLAQANYNSTSGGRRYGADFYDERMTAIRGVEVGDGVFECKLFEPERKEEEPRKETKDTNREASESDALEKPEERTPTIDPRDPIRWFGILVPPALRQAQSEFTLSVQTIIPQLTTTIAKLATLSSEIESHRSHADTKYLYKILTTAPPSPLPEAVQLLPLDISSSFIHLCTATQTVGVIEVFMPDSEELWLLKVPYSKVEKDIKWENVTHGGKREEFPHLFTEKLGSSEVEEVREVTRSEGKGWRESLEGMEWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A653</accession>
    <name>A0A2T7A653_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A653"/>
    <dbReference type="OrthoDB" id="3983163at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024645">
        <property type="entry name" value="Mitochondr_Som1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11093">
        <property type="entry name" value="Mitochondr_Som1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="75" mass="8801" checksum="71EE81D6AF6B1B36" modified="2018-07-18" version="1">MLHLEKIRPEELEEKVRKEEGIDLKGCVLKEMIQWDCRVVGEEIKCFAVERLFRRCANGRTIEVTGLERIGEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A688</accession>
    <name>A0A2T7A688_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_965337</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A688"/>
    <dbReference type="STRING" id="42251.A0A2T7A688"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="368"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU83259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="594" mass="67143" checksum="99B835DB0345544A" modified="2018-07-18" version="1">MAGRVEREIAYLQLLRHPHIIKLYTVITTPNDIIMVIEYAGGELFEYIVTNGKMTEDSARRFFQQIICAVEYCHRHKIVHRDLKPENLLLDDFLNVISGKLYAGPEVDVWSCGVILYVLLCGRLPFDDDYIPTLFKKIGQGNYSIPHFLSSEARNLIQRMLVVNPLSRITVADIRQDPWFNKGLPEYLRPPPEEFFNTGVDFSRLPTWKSIERGPAERLKGELHDAVVGKLGSTMGYAKDDVQDALNKEEPSAIKDAYMIVRENQMMMRDSRLSNAHNIKNFLAQSPPAWNSYLPSSPRHTPNPQTPNSPSFNAQTPQRTASPFALPGTKDGLGIAGVPEDVATPGDVGPSPSSSISILPTSLPAYHKAYMSGAPPPPSPAPSSPQIAPQQTRRGLRPINTRIQSSSSRIEGLTPLPPGHVQQAKRPRQTRWQFGIRSRNSPLEAVGCIYRALRKLGAEWELEESDNPDTDDWRSQHNRHNHHDHSQQNNKNKRTQTVPTDPWIIHCRWRKSSHTSATKRTSYPPTNPLGEEGLYVHMEIQLYQLEHNFYLVDFKCAGYERLGKKKKVGFLTDSPFPFLELASRLIIQLAEATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6S7</accession>
    <name>A0A2T7A6S7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6S7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="51" mass="5990" checksum="6CEF15CBEA7F6953" modified="2018-07-18" version="1">MPSPCNRVYCCLFLIFNMNCGIYSYQIYITRQNWAPTSCFVIIRVIGLLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A739</accession>
    <name>A0A2T7A739_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A739"/>
    <dbReference type="OrthoDB" id="5367079at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="17501" checksum="D6BD5D37048B2DFF" modified="2018-07-18" version="1">MSGISTVAIKDGHEGSRPNIDSNSLAADRLARLSAYTGGGYFDTLPTPRAASATSSAGGRLTPLTPYSPHPSHGGYTSAPSDKEPLVQSRNSPASSTTTSSVAEARKEARLISGMTYDDSVIDTTNRSPIPVLNRPDTEETEAVRRKGSKRERRAEIGNDVKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7A7</accession>
    <name>A0A2T7A7A7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7A7"/>
    <dbReference type="OrthoDB" id="5320605at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="22541" checksum="7A28EC05C8D527D4" modified="2018-07-18" version="1">MCIRHTTTLICGHVFATTTSCSDSCPTPEQAIAILPAKLAETSCLACVRKAQKSRLEWVGERLEVTLGEVSRLLGRAQRDSGYIKQEVESIRAWVDLLERRRNNRDGGIYDELKCVIRSSREYAGDLESGKFTESFELWCKMKNESGLEGYHVQEGGRGYGKMYDEAWERLLALKKPGDGFSEELPPVVGSKKQGECGGREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7T2</accession>
    <name>A0A2T7A7T2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_922272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7T2"/>
    <dbReference type="OrthoDB" id="5413544at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="577" mass="65045" checksum="0C649D5C1A3B1AED" modified="2018-07-18" version="1" fragment="single">TADWISSTSSLVAAIVALLTLITVYLASIQILTRRQVYRLGLSKKSLGPWKSIVVSPSALRMQTQIRTLTLSVRLLVSKGWEPKISNPVSFELGLKGTEVDLEAGTQASWVNFLEGLGVSPEDDGDFYEIRYESELVNGIVPMHWKGRDLAAICSILGFQSTEGRPNTEKLMELPTQWRGPLGWLQFRASLDGCIVEYRRGSVIKDQLSREFHRYYIENLGVESRPFKLKSRLWQSISGMCLSDNQVISLSERCKWAEEMSDREGRVGQSMDEIGNEPMECGKELTDEEIREIMFGRNTKKMVVLYPSGGHLWVSTEGELVHSRGLEIPPDGLHEYSYIYTDEDWVGNGYRHKLGRLCMDMNLLKLMKEAVLQIEPDGFCFSPSRLLSFLVTRVWSHASLISERCPDQQCIFPIDRLEFSAGEEAKKRASGEELYHAIKLINNFKSTSRAMFTTADMELVSKASVSLRRLIGSKGKDLIWAILASPDIFDCLFDLVTHTAMEDLLDSRLACESGRFNLIPPALGGIKVELVKDGIFEGIQVVAALMDVFLNFLWIDRSWVTDVALYDTTMPQSVTMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8D6</accession>
    <name>A0A2T7A8D6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8D6"/>
    <dbReference type="OrthoDB" id="5419247at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="595" mass="64911" checksum="F789B8E490B73CB3" modified="2018-07-18" version="1">MAGVSGITVESVDDITPGTIFLGHSSLPSHPQPKRRPFLALWKVGNQIVSLPLTSLASGGESVQIAAERFGRSTASYYPIAPSSNPPYLPVTATQNFSGFIDLLTPVTLGNSSLGRRARGTRISQRDLQSVIMAHVGLVQCGQEAVQTGQGEQESEMLLIDRRTHDSIRQMALEMLQCSEEGLLHARRTQEVTKSLVEAFDRPPAAKLILPRPQYPSPSLNSTHVDHPPPPPPPPPRSPQADIQQRHPAQQSSGQQQQQQQQQQQPLNSQYGSAGCRPNTFPGDPRNPESDGDGDGPPGTHTHWGSSNLSSAPTGSRSNKQRNRTPARRSGTNGNQVAQRQEECKQEGCQQEHQHEEDGNDEDGIDEWTKGDWAWVEEIIPEDKEKGKQPGEYSDSKPPSEWDPDDWDKLEDIIPEIATHLPPEDGSDSEGTQGNTVIPHPLLSPPFQEGQEEEPPSKDASDENDRRSNKSSSDRYNEHQRNFLPTSLPTQQPWAQSQFRTFTHALQRITARAQPQQEETSVPTAGSTGSESEDTEDIHSSGTEPQGVATTPPSAQATQTATPEEQAPTGQSKTMESETSPIRAVGPTETEGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8H7</accession>
    <name>A0A2T7A8H7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1118350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8H7"/>
    <dbReference type="STRING" id="42251.A0A2T7A8H7"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="141"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU84041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="226" mass="24589" checksum="724A2809B4515982" modified="2018-07-18" version="1">MSTPSSYQSSASYDPNLPPAPPPKPVSSAAGSRTASPMPAGALPAPPPPPPPPPPPADDGFIPPVLLNKSRDDLEHVLNSPQLLEALFATAHPTAASTDAVLIANLQYNAELATRLAALESKLATAREGAERALVEARQLERTWRDREKEMYQALQPFSSPALYSRLVNAVGDAEAVADAMAESFLEEGGRDVGEFVREYRALRKTYHLRKERKERWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8U1</accession>
    <name>A0A2T7A8U1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8U1"/>
    <dbReference type="OrthoDB" id="5408783at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="776" mass="84912" checksum="A13C24AAA535F391" modified="2018-07-18" version="1">MASTPSPLASPSSPADSAPQNPPDAGERTESAQETEQDKPHDRLLFDDEVKASIDAQEKMLLTMRKMCVLYYFMSESSSELSEAMIEYARVFEERARDDLTSSANQSEDNARFRCYSHASKFWSEMSTMQMAVHETLLNDYQHLNRQGARFFGLHASHDADDRLIVEYDIMLNRIEKVAGFHLPADFKVVESKVSEDAHLNPGYRKHARSKSEYSSKPRHTHPPPRACPVSGFTHEQVPHLEKPARYFGHFRHRWGELDIKASQILREASSGDERFKALFEMRDKLKISFAEKHNDALRDLETDFLTRVAVGLTNTGFDRLKDAYRKADEWASVVGLRTYANQLNLSPAKVQAKLDEPLKQNPGRPVIGSEFMNDEFQPDYQWDFNIDGSTNTTTDEIGRALSPGPLPEDLIEERAEDEDDESESDDSTSTSDDSTSPEDSEPGPNAPGHNYPRPPGGNSGSNSAGGASAGGRSNNSARGSGGRPSSANDNSFYSGSGNSYEGNRRPFEGLQASLLEQMIYELSDNELPSINSNSPSGSNCDSVGSLSTTQTSIGSIGDLFKSPKGSPSDRYTLTTGMTQPVPEVATTSVSPDTGTVEVALGKKGEKEKLSGATFGIVEISMGSKIVHGLVPGVAQAQNPFVNPFEDAPEFALLEDPDEDSVDDYKVIRPRRKHRHLRRVPRFVTLQGGKLQVFGRHNSYTGTGLKTKFPARGQPLKGYQPLNSSSSLPILTACDAVAESADLLSDSGSSGSTAFEPGNDLFYKIASGQAAGIIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A949</accession>
    <name>A0A2T7A949_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase NSD-like PHD zinc finger 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_961025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A949"/>
    <dbReference type="STRING" id="42251.A0A2T7A949"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone-lysine N-methyltransferase NSD-like PHD zinc finger 1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="2">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="2">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="63" mass="7042" checksum="CC81654F91660337" modified="2018-07-18" version="1">MSSAKMKVEEPEEEPVYCYCQQISYGEMVACDGENCPREWFHLLCVGLSQAPRGKSTSNPILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9D5</accession>
    <name>A0A2T7A9D5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1070043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9D5"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="517"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="853" mass="95859" checksum="FADA65E71F0FF220" modified="2018-07-18" version="1">MSTGSDESDSTPEETYIAYKIKTVFEFTPVAIDKLIRTYTQRQSRQLIPVECFFDSKLKLFVLWGDQEACYGAFKTFMDVLSVGTRDAITTIRYGDTVEAPIRRSPFSYLNLGAVQWTEDISDDDESDNRDEGDDDLISPVSSKDLRASTPRSIAEHKHTGTWNPGISALDFSHVLHPVDGYDFIEQISKVTGCTLSPDQASRVVKIGAESPAAIKLALRKLRKVLERYSRGFESIKVTLINPDDKKKFEIRLVSLEKQSELNRTTLYPHGSKWAEIPADNKFLIRMAEYSLEAGKFLNCKIEPHSLQEEFAYLANPQHRWERYLESRGVWDGDAGDQPVSSLSYTSGFLMEPKSNSGDDDGTPTLDLCDSQLSFDSHFSAPPPHEMRANATPTVKSTIRTVRVKKSVEQEKGIGSVIKGNSGLLDSEVILESPTLSPTLAPTRNQNHVFSFEGAFSEIQKPPPVVVPTTRTVRKPRPKKTDAGAPETGTKTLHRTMNQQAPARAKESRSDLTDGVDDSKKVTRYNVQKIQRVFGSCFTHVRGWRGHVRFEASLGRIILTGVPKTVWRRGIEWSDWGSSVEKLKEIKTHFTSVVTREAHDVEHVLELKISRFEAMFSGDLRSEKITYEFHCDVGSKNRIFVMDAQTFDVTCYNDVSDFGTVYWAYPTRAWDARIRLAGCKVLDLEAPGFVEFLASISIRGGESFPAVSFEVKGTGITVNKVQYRHTLRYQVNKKVCLGHEIDLAVTELQDLQVSRRNGPGRRYEAISTGKPAMTADERLSYSFSLVPVEIEKHLVENYNLEVGEEVTWNIEVLADKSGGDGILKALINVVDTLIQRIDDVGFDNNSMPYQRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAK8</accession>
    <name>A0A2T6ZAK8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000514">
        <property type="protein sequence ID" value="PUU72531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAK8"/>
    <dbReference type="OrthoDB" id="5457085at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="341" mass="38636" checksum="803726B6C3412ADB" modified="2018-07-18" version="1">MGEQIWRPTHTILDERVQCPNTDTSLQWPDFLRFRVLEETTPWEHWFHLYSKEHSGRKPLMRDCYLTHGWNKQAKTPIWLPRLVRNSGTLRAILEQWFTSPKDKVTIIFEYINKDQARVPTELVVAERFSDLNITLSDDEPLENVTSNPNSPIPVSRLSSDHLYSSPPLPTTATPAPIGVISNNQTAILVRNHRTPISLSQNQETHHLEPHLVSSPDPEPPPTEQPRAPRPAMEPDSGQSLTSINVWNSVDRSSLSLLSTIPDSPEINPQPPIALPDSIRTTAVPLRSTSKRNRVQMASSSPPQQSIRLQLPLTTHRVLPPRAGREQALKRVRSACELNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB05</accession>
    <name>A0A2T6ZB05_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_944813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000494">
        <property type="protein sequence ID" value="PUU72626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB05"/>
    <dbReference type="OrthoDB" id="5419268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="8398" checksum="0BF8A0AB4197ED39" modified="2018-07-18" version="1" fragment="single">LEDPGKIVQTGYSVGSQSHPQFDWAKNLLSKNFNTQEQQEIGYLESSVFALFWNMARKLIYGNIKKDIEGFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB73</accession>
    <name>A0A2T6ZB73_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1136809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000472">
        <property type="protein sequence ID" value="PUU72747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB73"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="21388" checksum="330D64C3545E5EAB" modified="2018-07-18" version="1">MHCCPGQHVTSKSVRSTNLTRYGVLTNSTTYGDKLAKVLQRPISEPPCGEKAAGYYPPPDGSWVEYIPRTEQLREGGKKSWPKAPKEVTWKDNWQNQDWTPTSPETTVTALHQQIGEMQQKADETARATEKREDEDLKKELESEKKRSRRLESVLRKTGKEVRQITNMLLDTVGKEKDKSPQYLVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBK1</accession>
    <name>A0A2T6ZBK1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1111522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000450">
        <property type="protein sequence ID" value="PUU72872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBK1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBK1"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="35754" checksum="E27CC02BDAA9EB4C" modified="2018-07-18" version="1">MWKLKIQNTVIQLARAQRTLQSEPQRLFRQFPIFSTGGRKAFYSKLRYCEKKKHFSEADLQIIQQNPLEDFRNTYRQFFLEKTDLIVEKIQAKPDILKLILNNATTEENSRELFHVFLLQLSLTDASGELRHPPSSNTITRKRILLFAGEWPNQLEIDGDALDLCADGLLKALAPETDVPDQDVWSSVYDLLTTFPATDSPEARKSAAIMAKDYLTKYAKEHPYLFALNIGLSLVPPLLWVLGFTSAGVGAGSAAAVWQSSFMGFIPNGSLFAACQSIGATGSALKISAAGWVASGAIIGATAIWDRIKGDRNPKKGESGSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC31</accession>
    <name>A0A2T6ZC31_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1035641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000419">
        <property type="protein sequence ID" value="PUU73050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC31"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC31"/>
    <dbReference type="OrthoDB" id="5219809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="127"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="34274" checksum="2255EC1250ED8D0B" modified="2018-07-18" version="1">MSTTDQESLCETPPPDRSLWRDTNIYASRNRDRLLGGLWAAEGITNANLYSMLEIICSFTDTFTLHDDSEHFVERNGQKLKPGNYYIATNGTIAITDEVALTRTSSMTSGTRVESFRQAVRERDGGCIATGRPAPLAHLGWWMNFETAHVFPLAYEKLWNDCNYSRFITDPPADPSHGTINSVQNGILLTREMHYAFDNYSWSINPDDNHKIVCFTPDLSYYGIAGRSLDQTFLDNNLRPPDQLLRWHFRQAVLTNVKGVGEPCFESDFPPGSDIMGAIMSGPKAGERLEFELFSRFNAMGYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC49</accession>
    <name>A0A2T6ZC49_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1006212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000417">
        <property type="protein sequence ID" value="PUU73072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC49"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC49"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="274"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU73072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="397" mass="40686" checksum="6CD7B706C2ED4D5B" modified="2018-07-18" version="1">MAPTPVYIVSAARTPLGGFQGSLSSLTAIQLGSHAIKASLAKVPAIEAANVEEVFFGNVLSANLGQNPARQCALGAGLAQSTVCTTVNKVCASGMKAIILGAQTIITGNADIVVAGGTESMSNTPYYIPTARAGARYGNQQMVDGVVRDGLSDAYDNQAMGFAAEECAQDYTFSREDSDAYAIKSYQKAQEAASNKRFAEEIAPIEVSGGRGKPNVLVEVDDEPKNLNISKLKTVRPVFVPGTGTVTAANASPISDGASALVLISEAKLTELNLTPLAKIIGWGDAAKAPSKFTTAPSLALPKALKHAGLSQEQVDFFEINEAFSVVALANAKILGLDEAKVNVNGGAVALGHPLGCSGARIVTTLINVLKQREGKIGAAGICNGGGGASAIIVEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC51</accession>
    <name>A0A2T6ZC51_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chs5p-Arf1p-binding proteins-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000417">
        <property type="protein sequence ID" value="PUU73070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC51"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC51"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="694" mass="78199" checksum="F8BE85CA66257A02" modified="2018-07-18" version="1">MVVPAVPEIVESEIHESVTARTESLPILRELGPPDLVHLIKSQPKVGLKEIGTYHHVTGVDASSSASLAAYINTLTYLIGENQIWFGKPQSWRITTGIYCCYNAFSRVDMRVEVKIPGSVEAYAVDERGEKRMASEMLWLETYLCGVLRAFNYADDQQNRIVGCRRFNPITSTEAEHKFLDAAERLFSRGWQLGSDPEIQVPNMVSNYLTSGLLTYIHTTGRFASGVNLFEKLRSKEPEVASLLARVLIDADEEVKAVSLLYETIKLLPLDSSLLDVQAAFCMSKGRYDLALECAKKAVNSAPSEFTTWERLAQVYLKLEQYELALLTLNSCPMFTYQDRDHPKMPQPSKIHLPVLPESVLDEMSDDNHDPKHDKADAALLKLPAASLKGTFAKAYGILTEITSQIGWDMLLKYRSSVFVMEEEYRFEKSASVTAVRGGSTSKSGDSDSEDEEQSDDKPAINGHNKEAEVKENGEKGKEDGDQEEHGNVIEKPEHSVLPEEVKGGTETGHPNSEGKISTQKYSHIQNKRLCERWLDNLFMVLYEDLRIYTIWRSDLARYGQQKRPYRKSATELEILGELAQRLHHHAEAEEAFQSRLQIRFSARALRGVLQTQEKNKDNRGALNSIIRLTAWQYRWYSEFSPAILYSIRKLIAEDGAVKVRSIVQATNFPQSVLDLTHNYAQLCAAFRSSGSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCB6</accession>
    <name>A0A2T6ZCB6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1095748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCB6"/>
    <dbReference type="OrthoDB" id="5313259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12136" checksum="88C3A035E8C13D4A" modified="2018-07-18" version="1" fragment="single">MSECGLRECAFDQVAIQQAVVFGYQVCSKKGFIEFPYADGLVSSLGIKVPANVTLPDRITIAANDVGGAPSFPMLDEDGDKMMFGSAAWKILPEDFRLVLALLLTTGFMIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD23</accession>
    <name>A0A2T6ZD23_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L22e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1069046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000382">
        <property type="protein sequence ID" value="PUU73373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD23"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD23"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14232" checksum="3A441F4285263B23" modified="2018-07-18" version="1">MAPNTKSAKAAKPAKVTNKFVIDASRPAGDKIFDVSQFEKFLHDKIKVDGRVGNLGDVIQISQEGDGKIVVLAHTQFSGRYLKYLTKKYLKKHQLRDWLRVVSTSRGVYELKFYNVVDDGAEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD76</accession>
    <name>A0A2T6ZD76_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1163028</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000375">
        <property type="protein sequence ID" value="PUU73447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD76"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="435" mass="47829" checksum="30B071583F21A6B5" modified="2018-07-18" version="1">MPSEQNVADQDLGSAPEVVNLNLPSEYDTSPEVLHTFGSEHGLRDNQNESYQNIGREPPKGKIWGMKRKTFMIMLGIFILLIIAVAAGVGVGVAVAKAKNNNNIVSESAQSEPRVTGTSSISSSPTPTPIRNDTPLAAVGWNTSNIQLLYKHTDGSIRLQETEGLGWGEQSPQITKPKDDSGLAAIGWLEGSVRQVRVYTVGGNNSLKESSWNSTGNLWYDRDIPIALDPPAAGSYLTAYTWFIGQVRQIRVYYQGQDGYIREAAYDFSRGWVKSAAPTIQSFPRAKSGSGLVVVSFPDTDVSEAKLFYQNMDGKLVSYDYQLKATFAQSWQNQDPTVDHGSVPDGTHLTAVAGTLTTGELILRIYFIRDGKLVEIWWTQKAGWVSWNMHDAAAPGISAVYYSGDVYVFFQDKTEYLSAVGLNGYLNKWQFTAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDU1</accession>
    <name>A0A2T6ZDU1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MIF4G like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1134756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000357">
        <property type="protein sequence ID" value="PUU73652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDU1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDU1"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="333"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="541"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="814" mass="90604" checksum="EAF0E0ABBA8C872E" modified="2018-07-18" version="1">MGDYYRGREEGRGGGRGGPRRPQKRRYRDDEDDDKEYRRSRPYEREDLASRLRRDTISIAESPLTKIEDTINLIANTFASNYDNEELRNTFLNTLLSLVVEQPFKIPFLAAAVLVINSQNAEAGKLILDEFGKAAQAYLTEGFLTSAKLVLRFLAGLQGMVEGHGLYTVLDGIVDQAAGYLTAGEAGLALDLVWIALITVPYILASSGSDNSLASELLKKTNSITEAKHRMQSLLSPFTGGYAPYDARAQGTHNARILQLNLEAHLGSEPSRPFHGVGCLPRPFESFLPELEGATKHPMPEITLPSDYPVDKSSIMPNVYFSVFADPNVETVPPPLELASTLFRDAIVDTIDTLDCNRLVVSRFLIEIDCYFSPNAFIKRAVPFDRVIETAGAEGSTWKPEDVAVDAIFSQLYKLSGPNHKLVYYHSILTELCKLAPAAVAPSLGRAIRFMYKNLESMDTELIYRFVDWFSHHLSNFGFTWKWAEWNENLTLPDVHPKKAFILGALEKEIRLSFATRIKGTIPDPYKELISEAKEKEQPHFKYDSEDEPFCNEAKEVLHAVADKKEDAEVDAILAKIIELAKESGVADPLFVARDAYVTSICHIGAKSLSHVLSCIERCKEKLLAIGNESPDARRQIVGSVLSYWEDQPGIGANVVDKLLNYSIVTPLSVVEWVLHDAGNKALSHTHAWEMVSTTINKVNTRVRQMIAAKQVMSINDYTEEQLAVYAQTLNAAEIEQGMLLNAVTDALTAMSDSSDEMNGGIDVESKAWMQWWAKGWLRAFSRKFGVAEGTVVEQPAAHGEPSIKLDPEDMDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFS5</accession>
    <name>A0A2T6ZFS5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_461670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFS5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="109" mass="12977" checksum="73769842FE22A85F" modified="2018-07-18" version="1">MVSLGFFAAKDEVPNPSRKIKKRNHAPFFPHCIWSFFPLMPQSSILYIFYCTIFIPVISWVEAFFIRLFVYFLSLFTAIWRLFVVFSYLAFGWLCRFAYPLAMMTPVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG35</accession>
    <name>A0A2T6ZG35_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dUTP diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1000581</name>
        <name evidence="8" type="ORF">B9Z19DRAFT_983781</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000299">
        <property type="protein sequence ID" value="PUU74445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG35"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG35"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="6">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="92" mass="10026" checksum="E483376F33744D79" modified="2018-07-18" version="1" fragment="single">STNLGIRRLSTTARIPTRGSALAAGYGFYSAHDATIIRRREVPVNTHTQLTIPAGTRTVASRSGLVTKNFIDVGARVIDADVYPPFILLFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGD2</accession>
    <name>A0A2T6ZGD2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1133107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000292">
        <property type="protein sequence ID" value="PUU74561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGD2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGD2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11367" checksum="F6C1B26898171BE4" modified="2018-07-18" version="1">MTELVCVFSKPFFLTDADHRITELDEEEAAPGSYFIVSMASVLPTPDVPLAAAPRQVTAQYGTLRTKSFCKKIRERDRGCVLTGGVCVLGNFAAWDKASIPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGX1</accession>
    <name>A0A2T6ZGX1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1103300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGX1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGX1"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="90"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="185"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="189"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="334"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="381" mass="43760" checksum="E31C844EBB4627A1" modified="2018-07-18" version="1">MAYQPCDSYFVEDMEQDGVFAARRSRQEKARIDAETQMEIADEMSRMVSEEYQEDILDHMEVMEAETLPDVASIDIQTEIQWFMRPYLLDFLIEAHTAFSLLPETLFLTVNLLDRYCSKRVVYKRHYQLVGCSAMLIAAKYGDKKDRVPTIRELKSMCCGLYDQDMFIQMEWHVLQTLNWTVGHPTVDSFLQMVLQEVNYDPEVECMARYLSEVALFHKDFVSVRPSVMARSSLALARHILGRPIPRHSEWAGKYDTNVLVLLSQNLHRPSSILSRKYASPEYACVSTILEEFLARQAQIAKQRMPPTPPSEVYESSRTAMDEDMKSQDVHMTPSKGQQQVSMGYITPPVTPNAGYLADDGVPSSRMPITPTPQHQQQYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH44</accession>
    <name>A0A2T6ZH44_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1132544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000272">
        <property type="protein sequence ID" value="PUU74802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH44"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH44"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="540" mass="60595" checksum="3AC65171F0C02344" modified="2018-07-18" version="1">MSPALEPATGGESDDRDFFSDDSFYDTAEEAAPSYSPGEILNEADWQRRTISDLCRLIGTEYLDINPSYQRDVVWTFERMSKLIQSILANFYVPPIIFNVIKFIENGERRYKRVCIDGKQRLTSIRKFVDGEIPVLDGRGQKWFFVDVGAGKTPKRVLPATIKARFLQTEILCVEYDSLGPEQEEDLFSRVQLGVPLTPAEKLKASTGEWQEFAADVESTYANLMNSIDNKRARSFQLILQIFKQMTCYEEGKPATFNSGPAALKKFVQNTSLLTSEFKREVSRVFNTYAEVYEQYPNTFNNHDYKFATKYSPIEFVAMALLIYIHPERQNIYLLSGDILELRSFVRQARQDLRSNSATWLVFMDWISNIERYRGGSNTVRARRRGASPVASPIAGPVASRVAGRVSRQVAEPAVQTASAPVADMSNATLVQPRNVANPTTPSMRSLVGMSHLGNLGPGQASSSPGTKSLPPPRPARSQLPFPAASSSADRRQGRIEADSNRPRKRARGEDRGENNESGERRIKEEKLKGLERVGPFTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH81</accession>
    <name>A0A2T6ZH81_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000267">
        <property type="protein sequence ID" value="PUU74858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH81"/>
    <dbReference type="OrthoDB" id="5504215at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="924" mass="101518" checksum="6146DC4F9C76AC4C" modified="2018-07-18" version="1">MTDNVNENGERGLVPVSRRTYMAPGGDYTRLTFEHVENCKCGDEASDDHIRMIIRNGGFETFEQVEAAIKGILLTRGCFECRFDRRSTLGMYVRQHSADDSSFGPSSGNLVWDSQTTDGGTHLTPKMLEQPVHPDQASISWPSVANDSQSAQRVAADDAPQADSQLSSSYDGSGLPSSIMRRLSPGEQRMYGPGFQLDHASDVTYRPSGDVSSPAIGSGFRSESFSQHIPEVRPAVPMSRAHVRFAGRVKAVVPPLVERTPSPRDVPMNLGSSKNTNGSGMGDSKHAIPESSVLSQIVSVPPTASSVTTDMIDALNDITAGRAQSPVSESSEYSHINISEVRFEAKDGYKNIDDVIDDLRLLGRSHNKPTEVLDRALGTIVSLESRESRNCRRIEELEDIIDNKRCEEQASGPAMRTIGKKNEPREKNKNPTSGVKGPAPPIPLRINTVSGPAACVTNIWTEVVKRNNKVIPTGKLVNPPSRNTKQQSAIPNLIPARDRYLTMRFATRNNVVLPEGCSTEAIRARINSFFTNRAKIGSGHPYLKEARLRRDIGCIYMTLADHSADDIYGMLAGCHTVLLRDLNLPDFMFEKDTKKVKILVLGIPLCDTGRGSLWKVEDWTGDKVYDGLRVDLEQSNPGIITSGRPNIIGSINAMKSNKMTMCQVQFMAEKWKELDAAVNAGRICLRGGNRACRIWTEHKPATVCSKCQLIGYIQTMCSTQPRCRLCRGGHWTREHMCSVLNCPGETGESCEHTIRACFLCESSGHFTGYNKCPALRSTPDTGIPDTKHSPITADETSYTEVNDESRNRGRRNRRGWKGETLIQAQLDEINKGTGSAKIPSVKVDRVRNDKNHSKEVVVLPAPGLNKDPRIMEYENSGPSGLRAGPRKGRKADDKGKAVCEDVDADDIFGDEICGRPSTAPPRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHC4</accession>
    <name>A0A2T6ZHC4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric reductase NAD binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_997086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHC4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHC4"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000103">
        <property type="entry name" value="NADPH oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="249"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU74898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="561" mass="64363" checksum="FA12A5D12FF79C17" modified="2018-07-18" version="1">MSSPDVTYNENKRFTMKEKIDRWMVNEGYRRIFVAVFVLLHLLVFGFGFLHYTLKDNLVGPRALFGITLPIARSSALVLHVDVALILLPVCRNLISTARQTALNGIIQFDKNITFHKMTAWSIVFFSWIHTIAHWNNFAQLAIKQKLGFIGWLQINFTSGPGWTGYIMMTCLMIMAVTAMDKPRRANFERFWYSHHLFLIFFLFWSFHGAFCMIKPDRPPFCDGIGVFWKFWMVGGLLYLGERIMREIRGKHKTYISKVIEHPSNVVEIQIKKEHTKANAGQYIFLCCPEVSIWQYHPFTLTSAPEEDYISVHVRMVGNFTKALGKTLGCEIDKKGGGADRSKRRESRVIGVDKNTKEDVDPAIRRVLPRVYIDGPFGSASEDVFKYEVSVLVGAGIGVTPFASILKSIWYRSNYPQKKTRLHKVYFFWICRDFGSFEWFRSLLLAIEAQDIGHLIEIHTYLTAKIKPDDATNIMINDANAEKDAITGLRAPTNFGRPNWDTVFKSIRSIHKPAEVGVFFCGPKPLGSTLHVKCNQYSEPGFSFVWYGTPLLLFVTWLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHD3</accession>
    <name>A0A2T6ZHD3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAC3/GANP/Nin1/mts3/eIF-3 p25 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1091528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHD3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHD3"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="71"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="261" mass="29117" checksum="CD82572E27B18E21" modified="2018-07-18" version="1">MADKELKALHQALVNTVNKGDYASASKGLSSLKIALLQRDALIPSPTTPPATLLLARDILEIGALTSIHQTDDAAFSRYYSQLQPFYEDSRLSTPKTASVNRSKITGLHLLLLLSRNDIADFHTTLENLEAPEDDPFIKHPIMLERWLMEGSYDKVWNATKSSQVPSEEYAHFSQVLVGTIRNEIASCWEKAYASLPISNAKNLIFLDSEGAVIQFAKEKHWEVKDGRIYFPVEETEKEALASGTIIENSIGYAHELETIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHM4</accession>
    <name>A0A2T6ZHM4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_996657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000257">
        <property type="protein sequence ID" value="PUU74997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHM4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHM4"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="913" mass="99531" checksum="6460B2B6F16B889B" modified="2018-07-18" version="1">MPHQSSVSAVQKATKQARHHPYYSPQNNGGRINGIGQMNGSTPGPIRRRISRACDQCNQLRTKCDGKLPCQHCIDFTLKCEYARERKKRGKASRKDIQQQQAAAAAAAAAAQQNGMVNGNTSPANQIRVLNGVSRSSDLPPPPRPGMDRKPSSSAASTRTSLGDLHDLSQHQIHHHHLPAQHHHHHHLPTPDSPSLQLNHEGVPTSMPMHFDRMSPFQHQPPNGVGVGGAPRMLPNPSAHGGMSQSGSATTNGFSTNEFVLSPQHQPHSMNFPQNAASPLSGFLGGHSPEDSSPSWLSLPSPPSPAFSTGVRYPVLLPLLPHANAIIPPMLACDLLDLYFTNPTTALFQPASPYVLTHIFRKQSVLHPTTPRPTSPALLCAMLWVAAQTCDAPFLSASPAARGRVCQKLLELCISLLRPLVHVAFTPSQHSHGQNGPSSDSENGSVGIGLGGLGGSPAGSTGGREGVGAAGTLDDVLTYAHLGIVISASEFKSASLRWWHAAWTLARELKLNREIPHENVIEQMGEDGLDGHHSPSDTGPGSVHSHPTAAGDPVGRLEMGEEEREERRRTWWLLYIVDRHLALCYNRPLALLDVDCESLYLPIDDASWQNGDFFGAHEPHNLYAQHPVSPTNTGHSPQLHRQAGPVFEITGTGLFEFFLPLMTILGEVVDLHHARNRPKFGTVRQTGSEGAAMLGEGYEELVQHITQQLDTYARSLQQYEAAHLRPELGDGQEGDVKLTESDIQTKIVVSYGTHVMHVLHILLSGKWDPISMLDDDDLWISSQSFISSTTHAVSAAEAISNVLKYDPDLSFMPYFFGIYLLQGSFLLLLIADKLQGEASSAVVTACETIVRAHEICVVTLNTEYQRNFRKVMRSALSQVRGRGAPEDMEDQKLKRREVLQLYRWCGDGSGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI08</accession>
    <name>A0A2T6ZI08_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-2 type transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_996202</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI08"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="570" mass="64585" checksum="EA58FA9990A07D28" modified="2018-07-18" version="1">MGPSGAGKTTLLDTLSQRKRVGTVDGEFLLDGKNLAIDFSRSTGFRIITLLELEPLADALIGEPGVGLTVEERKRVTIGVELAAKPEALLFLDEPTSGLDSTGALSIVRFLKKLADEEGLAVLCTIHQPSAILFEDFDDVLLLTTGGEEVYFGPIGDNGSTIIEYFERNGARKAAGDANPAEYILETIRRAPGTRSWAEIWEDSTEAKAVVDEIESINGSRRAILNSEHHQDRTLEYAMSLSAQTLEVTKRVWLNYWRDASYGYSKMFSNLSMALLCGVLFINSGTTIQELQSRTFGVYAIVHVSQMILTGVQPKFLEFRTLYETRERNSRIYSSTAFITAMILVEIPYAVLGSLVFFFPWWYMEGLPRSSGSAGYAFFLVVLYEIWMPHVAMWIAAMCKDMTVMSVVNPFVFVVSNGFAGIFVQYAQLPEFYRRWLFWVNPQTWLVKGLVSTALHDLRIHCARDEWVTFRPPGGQTCGEYAGGWVEHAFGRIENLAAREECRYCRYKVGDEFLETLGMKYSTHWRDLGIFSAYIFSNIFLVYVLYYLFREVRWRRVFAGVWNKNNNKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIM9</accession>
    <name>A0A2T6ZIM9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1154150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIM9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6120" checksum="7D14DE3E74BC7665" modified="2018-07-18" version="1">MNYTSLRRSSRESPSIPHRPPPFRKLPLALFAPAVDGGHPRVSAICRPLPYLPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIN0</accession>
    <name>A0A2T6ZIN0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1090501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIN0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIN0"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11268" checksum="92DDFBB9C53E4C97" modified="2018-07-18" version="1">MSTAARLVKKYFRTLEPRGRITAGLVNCHSGPQQGVGFHTDAQTYIGPRAIICTLSLGVTRQFRIQKQPPSSHSSVTYAIHLPHNSLLVMTMGCKRIGSSPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIQ7</accession>
    <name>A0A2T6ZIQ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIQ7"/>
    <dbReference type="OrthoDB" id="5418367at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="501" mass="54574" checksum="5917059A7677E1C2" modified="2018-07-18" version="1">MKSNATVERVSCSNSPTKGVGVLTNTTQRPLLCELPSPNLMKNPVHLGGLEWRELVELQEEHEGTIRFKNITQDFMRQWVNEHAKLLERDELRFEYNFVNQSFAVQCMALPIHESLEDFFVREVLYSLGDKLGRKEAGKMVVVGGSGTTFSGFSGDGLGTSKKQPDSFIQLRKGGFPTIVCETGWAESIEELKQDARLWLLHTNGETKIVIILSFIEKHSKTKLACEASYQGAPSAAGSDKATVTTSNNGPTPFATGSSGARLPTDIRNNSPTLTAAGSGKATILSISNDNPIPSATGSGEATLPQEIRNDGPTPSATGSSETTLPISTIADRRSAVPPVTSDDMEKALIASIKEDMDINELAEKLFILNKQGGLSRPLLGEVGASLHLFKATDEGDDIVQTFFANLLPPEPKATKTPNKFGITLRDILGNLVPMGHDPAYEITFALEDLKEVVESSIPRTTRLRATDRAIKLIEKTVGLSREPTFAQRKRQKLNPIGTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIY7</accession>
    <name>A0A2T6ZIY7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1131356</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIY7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIY7"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="205"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="280"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="285"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="402"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="582"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="615" mass="68422" checksum="DFB696D96DD66F55" modified="2018-07-18" version="1">MDIQPSNDELYPIAVLIDELKHDDVLLRLNAIKRLSTIALALGPERTRDELIPFLDESVEDEDEVLTALSEVLGSFVEYVGGPEHGHVLLSPLENLAAIEEPLVREKAVESLNKICQELSQNQVEEYFIPLVIRLSKADWFTSKISATGLYTVPYSKATPRSQDGLRQHFAQLVHDDTPMVRRQAATNLAKFVKTMPADLVVSEMIPLFQHLAQDDQDSVRLLTVEVLISIAEVVPKDQQASHVVILTILRSLFGDKSWRVRYMVADKFEKIAKAVEGDVVRRDLVPAFVKLLKDSEAEVRTAIAGQIPGFCGLLGRQTLLDEIMSPVEDLVTDTSQHVRAALGTQISGLAPILGKDETISHLLPMFLQMLKDEFPDVRLHIISKLEQVNDVIGIELLSQSLLPAIVQLAEDKQWRVRLAIIEYIPLLAKQLGVEFFDEKLGNLCMSWLGDTVFSIRQAATLNLKQLTDVFGVEWARQTIIPKVMAMGNQSNYLYRMTTCAAITTLAPAVNVAAIEEFILPMIHQLIHDPIPNIRFNVAKSYGVLIDVLRKLPAEGTLANVKPEDTTTGPSDLGLELIQKQIVPNLEKLQADSDVDVRFFAGQAMANIGDLMQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIZ0</accession>
    <name>A0A2T6ZIZ0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_994467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIZ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIZ0"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="58"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="240" mass="27310" checksum="47E15A15DCC85638" modified="2018-07-18" version="1">MPRIVPNRHSGMPAIGDEESRPQTPSSVTNEWNDSHPCFPHRNPYVPTNSPLYESTRIIRIQRDFMISGDLSPAYSNTFPDILEPYVSEERFRMVIAHVNKELDKAFDPWNLWNWLDAMSGLLTLWVLEDIIDTYIKRKLRAVEAFLQQQNEELEKAGSQAVFVPLRRTGYMNLDIQIPNPIPLPDEGDQLPPDPDDKFNIAPSDAGSAVPTIEINEYIGSPTQPGTHPQYTTADHYPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK80</accession>
    <name>A0A2T6ZK80_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_304685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK80"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK80"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="249" mass="27486" checksum="ADC0787067AC2AC9" modified="2018-07-18" version="1">MQSVGPSIKLYIDGGVQVFWDAKTRDKDSQKAGATPVGFNKNLMSLTLNDEWNWRNTMPFEILDADQRVPSNSNAPPALSRGALWPYQDSLYLYGGSTSRLNDSFIGYQPPKTEDTVLWRFDTLSSEWSPQPLKSSDGRKVPRLSNGANAVVEDRGLAFYYGGRTDNGTSPDTQNSTAINFSNEFYVFDLKNGSARALPMDLVGAGRADAQMIYIPDIGKKGILVLLGGSIKPTGTTDDRFRGLFPRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL68</accession>
    <name>A0A2T6ZL68_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_991186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000195">
        <property type="protein sequence ID" value="PUU76235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZL68"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1247"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="828"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1188"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU76235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1604" mass="176319" checksum="1E7F767D8266AE47" modified="2018-07-18" version="1">MVDQGAGDDDDQDREEDYEREDEDEDDVFDGSYLGGVGGSSGLSNTLRALSGMVSGISSRLRDNLASLRQKDDPSTQLIALQDLAEILLVSTEDNLSGHFSPDQFVKELVSLMEDQGPFGENPEMMLLACRCIANLMEALPAATANVVYGGAVPVLCRKLMEIQYIDLAEQALSTLEKISVEYPTSIVREGGLTACLTYLDFFATNVQRTAVTTAANCCRNIPDDCFPTVRDVMPILLNVLGSSDQKVVEQACQCVARIVESFRHYPDKLEQLMSKEMMNAILQLLLPGTTNLVGPYIHTQFLRVLSIIAKASPRLSVDMFKMNIVDTLYQILTGVSPPVAHDGAAMKNDSVMTMQALIHRPREQVSETLNVICELLPGLPHDDVFGAAFDSQDSSGGTTKAPSDEGEDDDDDPDDKRRKMLEDCKGEMKRFATVLLPTLTDAYSSTVNLSVRQKVLNAQLKLISNLDADILKESLSSVQFASHLASILSQQDHPTLVLAALQAAELLLRRLPEIYQYHFYREGVISEISKLASRKDEQAALEKEAAERGDMDRESEDSRDSEDRMSSSPVSSRSSSSSRHVPASTSTGMADWITEKAKRFMEAHDRDENAETKQKAMTIMEELKSLAAGLKSRNNPDVLFERLATYFDNDNSLSSISSFELLNSYIVEALLAVLSSNSDPRSIDIRRAFLEVFMRSGAHPAASSEGDTPFSVLVHKLQDLLSRSEHFEVVTVHQNTFDGNRSSAASMLAKQLRLKLVADEDSEIPRPYRNIMVSIHAIATFKALDDYLRPRISLSERPRSGRRDPGGAGGGGLSNALAAFAAAAGLSAPNSRPGSLPGDAASSSTPAPPRPRQARRQSRNKRSNPEGASGSSSRGKVPGAERENQPTQPSGQEPLECMDERPIPEDDDMDEMDTVLEDLDRGLDEGPEPEAGAVNLEVGTTGKVTARKDDGTRVATPSGAPPATRNSGSSSQTSTSTNRGLPAGYPGAMPSPLDWHIEFSIGDHVISNDMTIYRAVQLGRNDTAEDQTFRNVWSTVHPIKFRRVTGPTPPEGSLSPAPDSSQISTGFPASLDKNKVSSSILQLLSILHALNANLDDVFTGDKEAVKPKNPQPLSQFVNTKLTAKLNRQLEEPLIVASACLPSWSEDLARLYPFLFPFETRHLFLQSTSFGYSRSMTRWQNSQSTGDSRQDRHRDDNRPFLGRLQRQKVRISRLRILESAIKVMDLYGASPSVLEVEYFEEVGTGLGPTLEFYSSVSRAFARKKIKLWRENESSLESEFAFGQQGLFPAPMSDAMAESENGRKVLHLFTMLGKFVARSMLDSRIIDISFNPTFFRTGENVDEAVAPSLGAVKTVDKDLASSMKLLRKFSLAKEEVDNNKALNSGGKARKAAQIVFDGVHVEDLGLDFTLPGYPHIELIPGGSDVMVTIDNVKEYVDKVIDLTLGSGVRRQAEAFRSGFSQVFPYSALRAFTPDELVMLFGRNEEDWSLETLMDSIKADHGFNMDSKSVRNLLTAMSEFNAQERRDFLQFVTGSPKLPIGGFKSLTPLFTVVCKPSEPPFTSDDYLPSVMTCVNYLKLPDYSTFEILKKRLSVAIQEGQGAFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLQ9</accession>
    <name>A0A2T6ZLQ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1194769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLQ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLQ9"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="179"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="292" mass="32062" checksum="D619EB0CBB52606E" modified="2018-07-18" version="1">MSYPPPPGTSSSLPPRPPPPSMPQSANPPAYSGFRPRQVAAPPPTYTQQPQYNQSYPQQYPPPYQPPAQQYQAPAPSGAPHIVNPFPLPQQSFNRRADPRYADLDPELQAQIAQQQSIYDPSTRASGNTTTTPVVSKVEGGEYPAAPLNKPKNVPTVVRQGGGQTWTDSSLLEWDPSHFRLFVGNLAGEVTDDSLLKAFSKYPSVQKARVIRDKRTTKSKGYGFVAFSDGDEYFRAAREMNGKYIGSHPVLLKRSNTEIKPIVVGGKKGVKDGRVEKKKKKKKGGEQKHVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNL0</accession>
    <name>A0A2T6ZNL0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_197811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNL0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNL0"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="316" mass="35516" checksum="752F728302C62FFA" modified="2018-07-18" version="1">MGRLVSYPSREFTTYSMGIIRRDAASGWQDFNASLKSFDKCMEKKYCKIPFIVICIVGGIIVFSILWCFLRCCLCGYRCCACCCGGCGGRREKKLKIDISPPVPPPITREPPAPEPPKYAYFDAHNDDALPIMPTLENIKHVAVEVKVEEHEMAPMKGVGNERSLTPAAQGLEHERRVPTPLQALRQADRRAPAPIGGYQRDAYGDRSVAFRSQSPEAAYSPTLPPVGVGYLGSRVCYQGGRHDQYAGHNAGYDDYRLQQSQAQRGDVAYRNTAQNAYGNYEANPYQAPQQPRQQQPAQDTYYYDQRERPQEWTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNP9</accession>
    <name>A0A2T6ZNP9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1086914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNP9"/>
    <dbReference type="OrthoDB" id="10005335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="384" mass="44141" checksum="6ABBDF7885DC75CE" modified="2018-07-18" version="1">MSEAPAGQADNDAPPTHTPYPHTLTFDTFVKRYVPVLKAAAEQGQRLPFPSKARFMGTLKLHGYNATIMFRNDDRHNPVFQSRNRVVTSQDKGPIPSLLNGKPLHLLVDKVMEIYNRGKGQPDAAPFSEIMIAGEVAGRDIYRNVAINRLPKFFCIFNIRVDGTWVDMREYKDVSMESERIFNIMNWPTWEVTIDFMEDTLEISNWLYEITKKVEDECPFAASFLDSRGRKISGTGEGLVWTMIPFEGEAWPSDCTMLWNFKTKGEKFEVVSRTKPAPPRDPDAIGLATAFVDYAITEARFEQGIEYLREMGILEHGQNGRRSTAQFTKWVENDVIEEEWERMVELGVEEAKLRRVIAERARNWFFRYLEEVQSEGVDTTADMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPG9</accession>
    <name>A0A2T6ZPG9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S16 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_987300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPG9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPG9"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="14979" checksum="3DA3B1DF4395FBBD" modified="2018-07-18" version="1">MVIKIRLARFGRRHAPVYNIVVAHARSAQTNRPIEVIGTYNPIPVPPADGIGKGTKHIELDTARAKYWLGTGAQPSDPAWRLLSMLGLLEPKWSIARLQSKAGKSAVKPKEPRNVEDVTKSIQGNIGIGEPGATAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPH1</accession>
    <name>A0A2T6ZPH1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B9Z19DRAFT_1086494</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPH1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPH1"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="234"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="529"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="998"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PUU77367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124411" checksum="766F3BFBEB9746AA" modified="2018-07-18" version="1">MPSVSKKRRMIVLDKNGKRQKEEPAEPGEDHVPHKKAKNDTLEQRRAQLSQHTKSSFEEDLGRLTQEVNELKTGGQEQDQHWSRPDLPESWNPQEENLIFQQIECDEGTFNRKTTIQLFGVTDAGHSVLLHVTDFHHYLYVAAPIGFTQQHLAGFRGFLEAKLQNGLDPAIARVQILMRENLYGFRGNQQSPYIKIDVTDPKLIPRLRGLIEAGDANYLKMWPAADGGLMTFDAIQYVMRFMVDTKISGMSWVEVPAGEYHLIDRREKLSNCQIEAKVHFKNLIAHPSEGEYQRMAPLRILSFDIECAGRKGIFPEPHQDPVIQIANMITKYGENKPFIKNVFTLGTCASIVNTHVLAYNDEGKMLVGWSMFLRQADPDVIIGYNIANFDFPYLLERAKYLKLVEFPYWTRLGHMKSEAKDSSFSSKQMGNRDTKATNTDGRLQLDLLQLVQRDYQLRSYTLNSVSAHFLGEQKEDVHHSMITELHNGTADSRRRLAVYCLKDAYLPQRLMDKLMCLVNYTEMARVTGVPFNYLLARGQQIKFISQLYRKAREQKLVVPNLPPQGGDDQYEGATVIEPERGYYKVPIATLDFASLYPSIMQAHNLCYTTLVKKETCDRLGLQKDIDYEITPNGDRFVKSHRRKGMIPLILEALLGARKKAKADLKKATDPFEKAVLNGRQLALKISANSVYGITGATVGKLPCLQIASSVTGYGRQMIMRTKEEVEKRYTIASGYTHDAKVIYGDTDSVMVKFGPEDLPTAMELGKDAAEFVSQKFVTPIKLEFEKVYFPYLLINKKRYAGLYWTNTEKHDKMDSKGIETVRRDNCRLVQVCIETVLRKLLIDRDVEGAQTYVKNLISDLLQNRIDMSQLVITKALSKSDYTAKQAHVELAERMRKRDAGSAPTLGDRVAYVIVKGAGGAKNYEKSEDPIFVLENSVPIDTKYYLENQLSKPLGRIFEPIIGDRKAQQLLTGDHTRTISVSAPTIGGLMKFAKKTETCMGCKIPLTKKEEAGGAVCSDCKPRFGELYQKTVTRVSELEVKFSRLWTQCQRCQGSIHCEVICSSRDCPIFYMRMKAKKDVIDAGKDLKRFDVDISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPI4</accession>
    <name>A0A2T6ZPI4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BED-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPI4"/>
    <dbReference type="OrthoDB" id="5413204at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52882" checksum="7BDC66F85C9C387D" modified="2018-07-18" version="1">MSFTAINSVAGGAKKDIGRGGGRETKSSDKMIVKDQVKELSAEEEKEREREKDRLEKEAYIAFLAGKYDILDSELTLSLKKSTSYLLLRHMVIRKFIKEYEPDERGKQFQTFCCHCDKFWGPYDMHNTTTSYLIRHFSIEHPELPKSYPEEDALLRRMKKGIVEDPTDSKDAKDTKGKGKKRSGKTKADGLEEAKASEEGAKGEGREQEERGGQASPRKLEKGKRSGAVAEPETPVQLKAAEVNAVSTKSKSDEALASLRKTRSGKRTGQPENISAAGISRDSPDPPTSRKRRRTETSAATSRKHDTPSVEKFLAEADLTLSTLLPPENDSAPLPPPPVQQSTTTATLPAPSSSTTPFVPATIDATIPQTPFTQSYRNLLTEFLASSETSPSVVESKEFHDLVNFLNPETPKFNFSSLFDEVFVRQKEIRTDKREKPDGSVRTKKFEDTLKKEKERRRKKEEGYRAWLFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPV8</accession>
    <name>A0A2T6ZPV8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNAse P Rpr2/Rpp21/SNM1 subunit domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_986535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPV8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPV8"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17398" checksum="E4675C58E4DFCC37" modified="2018-07-18" version="1">MARKKSTNSTTPRHPHPHLFARLNYLHQSAHLLLASGSANLSRNLVSTARTVAKRAVIRFDPSIKRTWCKRCDAVLVPGVSCEHRIENLSRGGKKAWADVLVVRCWRCGCLKRFPVGRVAHEKERNESGKARERGYDVTGEGKEKEEDTGGDPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQI2</accession>
    <name>A0A2T6ZQI2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1127912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQI2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQI2"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="135" mass="15571" checksum="5D80073794475AAD" modified="2018-07-18" version="1">MSLQKARREVIGRWPGHKCLMDLSLDLPPEVFMGQMQIHILGIGPGIWPTNEMGPSRWCLPLSTSDSRPNSNDSRRFDSEALRVYTLFGIVQDRYYRDSILRAFHPLDDLFCPQLHTRKGSKGGIRTIFVRNWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR79</accession>
    <name>A0A2T6ZR79_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1101608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000132">
        <property type="protein sequence ID" value="PUU78000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR79"/>
    <dbReference type="OrthoDB" id="10467705at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="16169" checksum="2C7244E7E91E6E93" modified="2018-07-18" version="1">MGVAGSEVVEGGEIDAALSVRGVAGRSAKVPAGPAGGLSMAPSNSTRRRASSVRSQDMQGRLLIAPGMYLICSASDGIEGPGRDPAIKGSLVELASFFSSSQFHGSSLALRDCIEGPAPPFYPSGSVIEFKITSAMPIPPSCWRLREPSTASSWLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRG1</accession>
    <name>A0A2T6ZRG1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRG1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="21202" checksum="DD32D05AF8C7FDBF" modified="2018-07-18" version="1">MAPQSLLKGKSLCRVFLDVWNALTLKPDSGSVRHAVTEPFNDGVLRHPICQPPKGSPHTSVFHDATESSEGGPDSGGVRYAIMEPLYDIVLHHPVCPPPKGCPHTSILYGATESSKGGIPGALGMQSRSPFTTSFYFILSVHRQKEVPIRAFSMVLQSLVKMGQVPGAFGLQSQSPIRMAFYTIQALHRQKDVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRK9</accession>
    <name>A0A2T6ZRK9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRK9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754496" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10452" checksum="62025DADD5A21225" modified="2018-07-18" version="1">MLPCARSALVFTCLFFFSLNKTSIVMNTNYNYSFTFLQLKSQSPLPNDNITSCTFGNLHHPRPKPEECPHSDPKHKVEQACVCATFLTLCHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRV2</accession>
    <name>A0A2T6ZRV2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1101482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRV2"/>
    <dbReference type="OrthoDB" id="5417803at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="17411" checksum="420DEC5D5AFAE51B" modified="2018-07-18" version="1">MDPISALKATICSPIFIENIAIVSRSSNALIPVTLTLSTIQILLAENKMDKFANEVCSLTLGVAGAAIGSVIGAPAGPPGMIIGAGVGGVSGGLLGDWVYGEVKEWLFTEGEDGVRPIDRIAEKFRAATDTLKVVAEVIAMIMHGQAESFAALLEHWRRPGGLGGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSG5</accession>
    <name>A0A2T6ZSG5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolar protein 12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1084235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000120">
        <property type="protein sequence ID" value="PUU78406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSG5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSG5"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="26628" checksum="5FAE18C349D46B36" modified="2018-07-18" version="1">MVTLTKRKRLAVEEISFDPEQRREYLTGFHKRKLARAKKAREEIEKAAKAERLEDRRKLRESRKQELRAHVTAVQEFSRKVALEAGDIESGGDEAEWDGITDDESGEGSDIQGVGGEDEYVDEEKYTTVTVEAMDLGKEESEDEEAAAERMRKREEREREEEKLMKKKEARQRNGPKEKKKKFRYLTKSERRQDRAKVKMGKAKRRKEREGDKEGQRKGGKLGKARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSI2</accession>
    <name>A0A2T6ZSI2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000120">
        <property type="protein sequence ID" value="PUU78394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSI2"/>
    <dbReference type="OrthoDB" id="3200925at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15724" checksum="0FFE4E4CDE38E958" modified="2018-07-18" version="1">MSDQPAASDQSSVEWETLTSKNGVTFKIGREKAASVPVVEAKSETPAEGEDFGITVDWPVGGGWTQTTEDVKTTAAITQYNLAEVDGDTFKYTLEFSNTDTYDYKFFDQTGDSYEVNTWQNRTHYVKYNSDKPTIVYISGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSS5</accession>
    <name>A0A2T6ZSS5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSS5"/>
    <dbReference type="OrthoDB" id="10454445at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="284" mass="32138" checksum="D8D73CC068B0EBC4" modified="2018-07-18" version="1">MGLRSFFCFGSKKGKRETQGRPAATLTNISYPIHVLTTNPIGDQYPQYFMKSSGELKRTANETRRGEEAKTGGRKSRWGRERRRRSDMSFSCVGSEGSDPPPPPPPPLPLAQRYTGARDNHPSILAPTNWDAWAPPPGMELKTDVICFSCRKAPGRDAIGLCRNCSPVLSNPNPRDSRFTISNYYRDSFCMTNTASRHTSQHGGMILEAAEVVEDDSETDYGTVDFSDAYYAIMYEEWLEQEEQNVRREEERIRKRRNDKKRERGRIGMHGVVGYDYAGGFSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZST8</accession>
    <name>A0A2T6ZST8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_896787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000116">
        <property type="protein sequence ID" value="PUU78560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZST8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZST8"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="85842" checksum="C12E79D97FEE0E68" modified="2018-07-18" version="1" fragment="single">MDGSLGTQAGLRPFLPTFIPTTREQQDRIMSAGNNIHPNPVHPQYLQPRQQHTNFSGSPHHSGHHSGGTSPYSSSFPMNSMNPNLPAPTPYAQSLPSRASSNPASSSNSQQPPQQQQQQQQQSSQQGGYLDPAAYLSMGDVMGMDMDPIPMGSNMDMDLSILSAEEHGDLRVLHERGRARDRLHAQRLHSMSHPDGPDGTGRGRGAGGGRKRSGSDDSAHEPASAVRGTNAGNRKQRGRPRLDTKDENAADRRRTQIRLAQRAYRLRKETTISSLRNRVTELETAIDGMQSTFLELHESAMKCLSKSNDPQTLGYGTNLKELTERFLSLSKGALGSSEGADSHDDEGEGENNDEGHSGATAKRRRSRDEDGGPESGGMQTNASNGVASYGGYEVSYTRQSNSRDSFNNNNGSQSRSNGNGRSDATTGRMGSSPTSNHYSDAYISSSPESGYANYVQPNNNSLQTAAQFRQDGPLPYEGFTYSFHETSFSRRLHRAALEHAHYMLTSPNADPQEVARMFAYTFCYLSKADVIRVVNRLLNTTTKESLHIRDYPEILPKGVRPEAMEAYLSNPDTSVFADGLTGEDMKDFDLRLEAKKMMLKMGINQKFLRPDEVEKYIMELGILTSNHQQQSHLIDPSLMEASKDRSSPKQQPERTLEVPEASTDYLTANRMPTPSYLIHPVTTPPPSSSPSSKGGESPSPSSSPHLTLEKKLRLFDTHSPPAARDELDTPTSTNVLEGVKKNFDIDVFVNQLVKKGVCLGRFPGFRKCDVEEAIRAAGLGAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT74</accession>
    <name>A0A2T6ZT74_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT74"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="728" mass="79993" checksum="3DB20EB1270A78BA" modified="2018-07-18" version="1">MNDGGDGITIANSKPEGVSIEEFIQQSSLAMRVTNELSLSNHNNNASTGNLALPPPIMDPNNNRYSSPTRLSPERTMDDRLSPERDLGLTLPRLPSSRHVSPARETSPQLPSPDPSEPSYTPAPTAPSLTPPSTIPPSSFGSTNRAPSTAGTENSFEVLSGYDPVPPSERHKQWHRDQRRDIYHPTPTSAFRPNADLPYPITPQLLRYYPYGGQNAPVPPPPPQPQVQRGEEYMMARRYEQDLPPPGPSPSPYRGQGGVYESRFNARGQMVSASPGGHYRSSSSDVSVGGSSCSGIPSFAREFEPRGWRIDPILTESSHHSSQPGSVQRKPDSIASVYANEFASQLDLILRSFKRPLVTLIFLGFFGVIISILMQNLNAASQFSGPLFPHNPNSSFRHASYADFPTLMNIESSFEKIVDSAAGGSALARVMKQSEMAVSDLSTVVRYSELKCKETLAERLDVFAKDAKGNVRALQGFGSKVGGVLDQLLSINQYALRELTTIQHQSHHQSFLTKLLSPVTSLLTSTPTPDPTDPQTHARISETFNKAAEVLESNLRLLVSDGETIFTSLTALTEQHKPIYDEIVREVVDIKKEEALVLSSLWTRFGGNAAQRKNFRENAQLLAVIGSYEEQARGYVESTVLELDRMTADLELLRRRVAEPLLVDGGNAGADGARDKARGAQIPLSVHIEAIEGAVTRLVRKRAQRREREGNWIEKMEGAKKEEILVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT81</accession>
    <name>A0A2T6ZT81_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1083368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT81"/>
    <dbReference type="OrthoDB" id="5364171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="247" mass="28699" checksum="BE9CB8ADD6482BB3" modified="2018-07-18" version="1">MSGIYYVYMKYTRETQNNRADNGRHLLTFQSRWDADELFRGLQALKTPAGASRFPTLKRVSPQFWCYDGVEPDPSLNIVLIQRENVLPEFNYKFMSVVLSDATDHRNWPILANPTIGPDWVSGKTFYIRNRRQPSLYWYFEDCLIAISTRRRTKFRIKDRRYDDERVLIRKDEVTIEPCGSLGTTIGKYVIKNGDGEMLSVGSTRQVWDFSDLFDSVGVTWVDGTDFSPETQFATSLPKLGDEWELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTC0</accession>
    <name>A0A2T6ZTC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase complex subunit H-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTC0"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="14207" checksum="72D317A04B1D2986" modified="2018-07-18" version="1">MLAQSLRVSRTSLTRCLARQQHPLRTFIVSTAPRKADLVQDIYLSALKSYKPAAPKEKDSEGQVKKWAPPAAPPSPEAAEALLAQELKAYETQEVEIEGQSTEPGAEAKEEDWFEEEANFGTEEIAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTI7</accession>
    <name>A0A2T6ZTI7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1126079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTI7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTI7"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HNH nuclease" evidence="4">
        <location>
            <begin position="371"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="467" mass="52295" checksum="A841A3D74C62021F" modified="2018-07-18" version="1">MPDLPDTLFYRTPLSWAAERGNEHIVKLLLAQNGVDPNTPCDQGRTPLLWAVNSRQESIVKLLLGDTKVDPNTPDDLHNRTPLFWAVENGHLGIIKLLLHKKKVNPNIPEYYTPLHWAAEHDDEDVNLPDTARTGFQAWPTDVVKLLIERKDVDHNSFDGEGQTPLVDVVISNHKNVVEQLLEAGEADANWGDKNGQTSLHWSAGLGNEGIVRLFLRLQNIDPNPSDISGKAPLSCAAANGLEGVVKIFLETKDVNLCFADDNGRTPLEWARLRRHKNVVNLLQECKGVILRPRDGISLTLPLDTVRGLGPDMRMRVPKDSDQAKTGNYNILTLATITVTNDNPLKQTIYPHRGIRTAAFADYVYERDSECTFTGRPLTYKFKPRISFNAVHIYPLKYEEHWRAKGCNAWITSPPADLSVGMMNSVQNGMCLTPAAHILFDTFQVSINPVDNYAIVCFTPDAENMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU55</accession>
    <name>A0A2T6ZU55_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU55"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU55"/>
    <dbReference type="OrthoDB" id="5372266at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="104" mass="11333" checksum="92E581D7661CE7D2" modified="2018-07-18" version="1">MLALWGWLFILFIGSISIVAAIVRYGALRAVWGQPKASVTDTIDVSSMVEITSSLFAVCSPSLRVFFGGKNKPHQPIERDVRDISTHPDLLSTVKSAMGRGVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU97</accession>
    <name>A0A2T6ZU97_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional adapter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_980574</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU97"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU97"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000115">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.90:FF:000008">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016827">
        <property type="entry name" value="Ada2/TADA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025024">
        <property type="entry name" value="Transcriptional_adaptor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="438"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU79056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="58679" checksum="E5C93E86AFCEA1F6" modified="2018-07-18" version="1">MGVIKKKAANPGRVEPGVRYHCDVCNGDITFTVRIRCAQISVCTDYDLCVPCFTSCAASGNHNPATHPYQVIEQHSYPIFTADWGADEELLLLEGAETYGLGSWADIADHIGGGRDKEEVKQHYLETYINSPKFPLPEHADPADMTYASVSREEFQARKKSRIDLKKKEASESAPTAPKKKPTTSQPACHEIQGYMPGRMEFEAEWDNEAEMAVKDLFFEPGEGLNPITGQVEPEADLKLTVMDIYNGKLTQRAQRKRVMYEHNLLDYRKNSANEKKKLKEERELLNKAKPFARIMNKRDFDEFSEGLVNEQLLRQAISQLQEWRRMGIESLEAGPKYETEKAQRALRNKLAPLDRLAHRYTSKATPPVETPPINPLVAPKTHLTSAPQDLAALSPTPANNVPTSPSPMVVNGLVKKNIVNGLNGTNNINGTGSGAVNTPLYPPLHLSNENAADLHLLTSAEQQLCETLRIKPKPYLCMKEILMKEAMKHGGVLKKKAARDLCRIDVNKVSKIHDFFVSAGWIGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUY8</accession>
    <name>A0A2T6ZUY8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUY8"/>
    <dbReference type="OrthoDB" id="5429355at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="19726" checksum="820F7D3384F0758A" modified="2018-07-18" version="1">MDSELLAHQARAAVDTLTAQLRSLENEQTALLHSLQLTSTTLSTLPAYNSIAPTLSQIPVYESKLARLKSAMAAQAREVEELKRRAREAGERRRRNLKRIEEARRGERERDRTVLKAQARAVEGEENSNNMERDDGEVLAEGEVKRGGMPASVGGPSREGVVKTVKRKKKARQAEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV54</accession>
    <name>A0A2T6ZV54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1125273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV54"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV54"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14723">
        <property type="entry name" value="ZIP_Ppr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="606"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="642"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="801" mass="89987" checksum="41B7AB3FB0A67F51" modified="2018-07-18" version="1">MEAKENNSSRKSPGASSEAERRGSSTDGRQGTNSDDRDTDANGRGSESSNAPKLYHTLTACTRCRSRKTRCDAGLPKCGPCERSGAHCEFFDSTKQKTIPRSYVVHLQNKVRDLEEQLRVREALLVEAEAPNSEELVRGVGLVNFADYEHYKEPRYVGSSSGVTVTRLVLEAAKKNLDSQAFKDLTTQHRNTFRHALRTNPDPTDPHANLSSLPASRLPSREITDKLVELFCARALYQLPVLHEPTFVQDVADVYAGSEDPFKNFQLKMVLAISMQKLSKRYASLADSYFLAGLQHMEDVLEAMDHRTLQCLLVMAQYALVTPTRMAVYHIVGIAVRLCMQLGYHQERTIMLSATPLDPITKDMRRRWFWTSASMEYGLSHVLGRPSAFATADAFVDVGFYEPVDDVYITAGGILPGPVSVKKLISMHFFRMRRLQAEIRQTLYQNPREHPKNNSDPWFSQIHAKLDNWRASCPVDEHGGTMNPDWYHLMIIFTYRPSPQIPQPSAEAVSHCYNSAIKGIHLQKKMFEEKSIDFTWVYLHQIYTATITLIWTLYNDQIREMHHREEVERNLEISLSLLTILAERWPGTEAAADLFDRLGQAALQSYSANSGHSTQGPSVKSHRSHAGSSPATRASFSPYRHSSPYTYESSSGSQSVEEMTPSPGTSGTPTSHGASYSARLRSTDYENEQNHSPPRPELPEVADLPGIFDPASVYNVFPTNGIPGFLGGWDPTDPFVRGTTDPQNIEALGDMNGRPIGIDAANVLNQQQQQNELLNILQDESSQRFDVTRQWVPDYESPQFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVW2</accession>
    <name>A0A2T6ZVW2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVW2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="18963" checksum="D57315C388A2A8FD" modified="2018-07-18" version="1">MGSSFKHIVAQKLKGENIDSKASVPQVSPHVASLQMGISSPPQVPFAIAEERRIPGQGWKTRQSVPVSRGGASCYCNGAGTTEAETKADHGSRSVTFFNFVKGPIQTVLRRINPAYSSYILDVDSVPKRLVRTMIRTMGGQSSQSSHGFEKPGPVWQKLLTATKPPGAQGADRSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW02</accession>
    <name>A0A2T6ZW02_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_978451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW02"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW02"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="188"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="782" mass="89463" checksum="F0AF97294411DF52" modified="2018-07-18" version="1">MSVTTMLAPSARNSTSSTSSSFVPVSRQNTIGSDGAPRSVRASKRYSVTALYLSMSAQDKDMEIEDELARVQKTLRDLKSRISSQSKKNFVLEKDVRYLDSRIALLIQNRMALEEQNEVASHFDESSELQEGSFPDDRKTQQYGNLFFLLQSEPRHIAALCRLVSMAEIDSLLQTVMFTIYGNQYESREEHLLLTMFQSVLSAQFDTTPEYSSLLRANTPVSRMMTTYTRRGPGQSYLKVVLAKQINNLIELKDLNLEINPLKVYERMVKNVEEDTGTLPANMPRSVSAEEAAENPQVQAIIEPRLTMLMELANTFLSTIIDNINETPYGIRWICKQIRSLTRRKYPDAKDHIICTLIGGFFFLRFLNPAIVTPRSYMLIDNIPSEHPRRTLTLIAKMLQNLANKPSYSKEPYMAKLSPFVTANKNRISKFLNDLCEVGDFYESLEMDNYVALSKKDLELNITLNEVYATHNLLEKHAKELLQGRDTEHLTILLQELGPAPPQVPRKENRAIILPLFSRWESALDDLSAALDITQEDVYFMEAKSIFVQLLRTLPPISAAVRRPLNLQKIADVAATTKDIGTFRKGIRGLELLNQLKDLGVITETDGYQILREEVEQELVHLGSLKEKVSEESLKLDEVYKTIRDHNAYLVSQLETYKSYLHNVRSQSEGKQRGKQQKQHVLGPYKFTHQQLEKEGVIQKSNVPDNRRANIFFTITSPTPGTFVISLHYKGRNRGLLELDLKLDDLLEMQQNNHDELDLEYVQFNVPKVLALLNKRFARKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWH0</accession>
    <name>A0A2T6ZWH0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_790501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000081">
        <property type="protein sequence ID" value="PUU79828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWH0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="19294" checksum="2DFEDBB78DD91F61" modified="2018-07-18" version="1">MCSIVSVSQIEIRFVHPFTTLKTGKGKQASKDMPATHTLRKTPTRVQNQTSFPSLPSLLLPLPPPSLLCSSSQRKKSSYSPPPPPKRTRSSSLSHSNSQSKTNIPTLINHSSSWKFRFPTNFPLILLLCTFQLSYSCSLPSHYVLEVNPERKLHLLFVAEGNLWRISCFPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWP6</accession>
    <name>A0A2T6ZWP6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWP6"/>
    <dbReference type="OrthoDB" id="5390209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="204" mass="22109" checksum="FE13DA531D6AEE7A" modified="2018-07-18" version="1">MDDSIINSPFPHHSEPPFVSPFITPRTHSRLRNPTTLTTTRANRTPTRATRSQRNTATTTDSITTGNRTISTPLPAKTNTRLSTLSQPAQATSSPHYAQETISSAAKRRFREEEEEGMGGGIHERIAVLEAEIRMLREQRGWIVGMIEEQKKKGGRIPGGGENDKGRDSGDGDGEGVTVVGYGNDDEDGDGIVREKGNGNGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWQ0</accession>
    <name>A0A2T6ZWQ0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1100600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZWQ0"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="718"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="805"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1453" mass="157763" checksum="A27FB5DB96A801CD" modified="2018-07-18" version="1">MAPPSSPPSVPFTGCSVRNRSGYTGGIREALRSRELYKYYQPPSDNSPSTPLGERLDHQKVNVGPEVVSSEDPTLSAFTLLTANLLNCKRSMISLVDDELVYMIAESTRSLSLTKPYTHDPGDGLWVGGCMTMPREGGLCERTISLVPPEELNNGEECVMIFELEDMAKEPEWKDHPIVSNWPYLRYYAGAPLRTENGVSIGTICVVDDEPRPGGLREEEKRTMAKMAEIVMDHLERVRAENEMKRGKMMGAGMSRFVAANFLQAGAEFGDIRNGGRLQSIGGSTREEKLVQGEQLAWVGAVCSQDHGKRDCGYEKQGIRRQPSVESHCSCKLDAPDQDLPGTEDNIDPLSPLEKPRAVGVLSNLKSSQLPLSFPSPDREDFGSPESPFRSPRTYPPELSRKLSYCSQSTSGLATFSGNASGFSGTNTSAPSASPAESLSPPTFKEPDYGCPLTLDAQPRYRDGDDVENSFLSTFGRASVLIRSSLEADGVAFVDCDLGRNYGFEANLEDAVGGTPKPADAYRDQRPSRSGRKSGLFGYATASRSSLTDALEGEGFFGHRVGGTGDLPFFVEALSEPFLRSLVDCCPQGRIFTYSKGVDGQYEAVELECDVGCSEIVSNVSDSGSTSIHLRGKRVCKTQIETLKKFLPGSRSLVFAPLYDFDGNLFAVGFVWSNSKTRVFCKDIEGTYMIAFGNSIMAEIGRLHSVSADRAKGDFISSVSHELRSPLHGILASAEFLSETDLDNFQRSFVDTVESCGRTLLDTINHVLDFSKLNSFDNRWGGGGRGSALKGERAVGKWSRLNGRSTMGDAREIPPMQAGSEKDGGGCEGRLTSRWARDPSSSAADVDNLTADTDLSAILEEVTEGVFAGYEFRGISTPGIMEDVGKTSDLGTGGRQMVGTKNDITVIMDIDRREDGWVFQTQPGALRRIFLNLGGNAIKYTDSGWVRIKLRADDLPPDLGDDDEKSLVTLVFTDSGKGISREFLKTRLFTPFSQENPLASGTGLGMSIVRQIVEMLGGEIDVKSELGKGTEVTVSLVLKKSNRRVTKPNESYDTGGKRDVGDWETEIESIRRKGHGKKVRLVGFDSPLEADIHAASISYLGSSFKRYISHWFGMTPTGESFPCDVGADFVIAHEGPRVEEHLTRQIRGLPGIEGGKPLIVICSNASRHQTYQSLSGINGGGIVYFVSKPCGPRKLARALADCIKKMETTSRNGNHGPLSPLTLPDTDSPREPTIGQTGTPSELKSRGPVGPGKTSWSLSKNTGTCDVKLLAVETETDSCSTSPDPMRPAPLRKDEKRPVALHRELSASSVSSTVNAGSTLDGTFPTALIVEDNPINLMLLATFMKKRGYPFEKATNGLEALRAAESRPEGFDIILMDLQMPVMSGIESTRAIRNLEKQSRTKGSVIIALTGLAAASDKVEAYEAGIDLFMVKPVSFKRLESTMKEYALIGEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWS8</accession>
    <name>A0A2T6ZWS8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWS8"/>
    <dbReference type="OrthoDB" id="10555982at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11142" checksum="F015B87D893EC7A8" modified="2018-07-18" version="1">MSEFTPLISTSSTPLNIPSVLPPIFSDLEAQAAYFRAREKYEADLLRRIRRRAVINKVIVVATVGIGVLMIGLLVDGSEEEGWQGFGASRMKSTAISSRETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX16</accession>
    <name>A0A2T6ZX16_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1080318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX16"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX16"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="8918" checksum="98BF29EAE9CADB4B" modified="2018-07-18" version="1">MLDKTLQWVKVGGQCDWSPEKYPMDSSSLPEFLPDIPVFVSSIFGNAAQTAIVNIYSPGETLAPDRDISESSPAVVVSFARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX63</accession>
    <name>A0A2T6ZX63_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX63"/>
    <dbReference type="OrthoDB" id="5351184at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="609" mass="69338" checksum="F282CA53DDDD6069" modified="2018-07-18" version="1">MITPPSQQQRSFDERLVWLKQSVHRELRGLDALSFEDSGVIEAALAEVRRANADTVKALFPLLAHVNYIDDRLVNRLNMWSTTRAMLLWFGGVKSFERLIWGRRDGFYDAIERATTSFELALETTELAAKCGKKMAVAAGRVCNKNVLKLQGEISNIGRELQDVVKLCAEEEENVKLKSKYLEGRLEAELRGRENLEDEISEEPNRYGGVLKASVGAARTVIFGLSLAFTFTIPGLFSFGFFASIGIVTFLASWTKIFYREKDTQGIQHKIAYSEQKTEELERQLKAIKMKASELRKVAEAYGEAQRVFSLLSPRAGSMQLMTSQFETLLSKRKSVAESRLARIRDIRPPNSPSWYRPVRADVVDLSEEILKQFKQDYEEGTFTTEEEAIIMDLEEKIGHLRSRTKALQQIHARIRIESEGIENSNEMQRGSPEHLRLSAIILLGATMAVFYAWSHSQYFLQGAKFVTRQARRSILWTLKGILIKLWRTVVNMLIGLKTPFRLLCAMAPNVTYFALNVSLYLGRLFFSYTFLLPVKILIVVGLLLLRVLTTRLIVFGVMGWFLVYHGPAWDEIWNAVYGWTVWGILAGWRWSWEFSGSEGASQALVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXQ1</accession>
    <name>A0A2T6ZXQ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1079876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXQ1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015779524" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="94" mass="10867" checksum="B600D721E92419DF" modified="2018-07-18" version="1">MVFYSCALCFFLSFMECCYCLRNGKLDLNARREGGGGWFLGSVFRSFFWFLFFYIIMPVPVLPCCGCVFEIFVYGGVSVESGVSFFRSVWYGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY03</accession>
    <name>A0A2T6ZY03_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_739119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY03"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015514182" description="Secreted protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15498" checksum="E05023D28D8EB8E3" modified="2018-07-18" version="1">MHTTRCAILLSWFLHSALANLPRPSNDPQHSWLTKPGPIASASSPIFYAVFIILIPMWVREAAFASSTCLKSVAHATFEIALYSCHSNLNLKLLYSTLFVYGTGAGAMTKLLQLFVRDDALCSESLVLSPVLSHRISYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY64</accession>
    <name>A0A2T6ZY64_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_975013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY64"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="295" mass="32904" checksum="B7DE4B075F5AF200" modified="2018-07-18" version="1">MGVDRLQYGGSHWFKAAINKQISGFLFNGAAQYVVFSPVTQKDLEEINNIRDAHYRGLRFMYIGSERTLIIKFGESLVHQLAYRIFVRCFDEKLSEMGLSRELECIGAAGFSGLGSEKEADSAFKPRSRPFEDDWPTLVFECGFSEFLARLQVDAQWWLENSAGDVKTFIVVSVSKPERSVHLEKWELANEPDPSNPPLFPPTITQEVDIIGEEVRISSKGVTNTSFVIDFTKTMLCEPPACPRGGGNFTFSKEDLVDYAGRIWDASQTSPASDVRIIGSRSCPTGISHVALKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYC6</accession>
    <name>A0A2T6ZYC6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000063">
        <property type="protein sequence ID" value="PUU80498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYC6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="281" mass="30809" checksum="0F7CD4C2DED0D6ED" modified="2018-07-18" version="1">MLNKQKTPFYRRIFSFNTEREAISDGVQSARSRSGKQQHQSSNSPSTLPKGQLSHFYHGPPNATGALERPAKPARRRTIQSTKYADIETEHDEQASTEIVRLSDNSIDKYQNCRGSDQTESDTEPDAEDNDIPEATGAGLRHRSQTVDGHINNRVLTARVSTTSGSQEAALVRRTPAALGCIMPGRAYTRPVLLSSSVARYLSPLATHCATTSRVRSSSPAGESSTPHHERIWPNTLSQRNTARGANVAVVSLAKALILWYTLFVDPLPVPVTLTSQVHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYR0</accession>
    <name>A0A2T6ZYR0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1078917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYR0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="8353" checksum="F8FFA47D27C400A9" modified="2018-07-18" version="1">MPRIPAMSGPDKPTVFPRGAWRLPHTTSVGLVLAWDRVPVATHTRHAQASDSLWRLLRSCGRKVDNYFYCGPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ23</accession>
    <name>A0A2T6ZZ23_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1078852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ23"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6501" checksum="CB837B1C7B8A90D4" modified="2018-07-18" version="1">MRYLRPSIRPTTTTTTTTFRINKQKEKQAGMKIRRVVQSASQVRHHVVPLRLRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ90</accession>
    <name>A0A2T6ZZ90_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000056">
        <property type="protein sequence ID" value="PUU80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ90"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="18671" checksum="FA9A8F7FBDD27793" modified="2018-07-18" version="1">MAPRKKKQKANNAGGHIPLDIPATKNAGWTALAKKTQAHTKDIETPSSAADGSRDPKTDEYSGPRFDYMAASIINLFDRAVSASIAANSPIIPPGGFNQTNLETTVAIDGQMDPEQPKRNKHKLCPPGAHVAGSAPTCDTSAGEPNRQMGKSGAGTECEGEGGGAGGGRKYQVEDGIDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ98</accession>
    <name>A0A2T6ZZ98_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_947899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ98"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ98"/>
    <dbReference type="OrthoDB" id="5419268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="351" mass="40413" checksum="9AF165201DCFE5C1" modified="2018-07-18" version="1" fragment="single">TLSTLPPSDIYPPSNHWIYESEEIRALWKYHLKHGKQPDARLKRHPLQLLDESKLKLDIAGDESAIIQDQATGEIVAMVYRNFMPGQYHSILEWINATILSSIGRKKSARLEDPGKIVQNGYSAGSRSHPQFDWAKNLLSKTYSTEEQQEIGYLESSIFALFWNMARKLIHGDISKDIEEFLETGIARMDNKGKQKANNTYTIQHEQEIYEFNQGELAPPVGFFASNYSRYLEKLLTETFRAIHKETAPHKYSLFWTTERSLEANQGGNFFISDYGIRIRGAENTLVAWQTRMFHGTSLARLDSIESYTGKGQVGLSIVSPNRLPKIWERYMNEGIDEEELKRELEEGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0D6</accession>
    <name>A0A2T7A0D6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Squalene synthase</fullName>
            <shortName evidence="15">SQS</shortName>
            <shortName evidence="15">SS</shortName>
            <ecNumber evidence="4 15">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1122383</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 15"/>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0D6"/>
    <dbReference type="STRING" id="42251.A0A2T7A0D6"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU81218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="472" mass="53646" checksum="F7FD8C7A7E020397" modified="2018-07-18" version="1">MKTSDILYLLAHPNQLRAIIQWKIWHNPLHERNIEKESPTLRRCFEFLDLTSRSFSAVIQELCPELCVSVALFYLILRGLDTIEDDMTIPLGIKEPLLRSFDEILEKEGWSFDGNGPKEKDRQLLVEFYTVIKEFALLPESHRVIIKDITKKMGNGMADYANNAEHNVNGVNTVADYDLYCYYVAGLVGDGLTRLFVDTGKANPALLERPHLINSMGLFLQKTNIIRDYREDLDDKRRFWPKEIWTKHIEKYEELPLPENEEAALNCISEMCLNSLQHADECLFYLAGIKDQSVFNFTAIPQVMAIATLALVFRNKDVFQKNVKIPKGEACELMIEVGNLRSTCDIFRKYMKIIHKKNTPKDPNYLNISVTLGKVEQFIESIFPTPVEPKAVAARAQMRATGETPEQAAAAKKETMLLIGAIVATLSVISGIMIFVAWLMGARFDIAFQELRKGSFRPPGYNPVADAPHGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0F3</accession>
    <name>A0A2T7A0F3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_972292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0F3"/>
    <dbReference type="STRING" id="42251.A0A2T7A0F3"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07197">
        <property type="entry name" value="nitrilase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF16">
        <property type="entry name" value="CARBON-NITROGEN FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="290" mass="32367" checksum="22426E58D65D1920" modified="2018-07-18" version="1">MSEIPLKWKCAVIQLHSKPMQVEDNFNRAQDFIRKAAEAGARLAILPEYFLTSWVPNDPGFADAHVDREYLSRFCELAKECSINIVPGTFVEKHVDDGKDMLYNVAYFISNEGEILGSYTKKNLWHTEKAHLEAAGNNPHTVIDTPLGKVGLLICWDLAFPEAFRALIIQGAKIIIIPSFWTLLDLTERAFQRNPKSEAIYLGSIVVSRAFENTSCIAFANAGGPEGSVFAGLSQIAMPIMGDIAKAEGAHEQMVIGEVDMEILQDAEESYKVREDISRPDFHYPVYAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A167</accession>
    <name>A0A2T7A167_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1113409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A167"/>
    <dbReference type="STRING" id="42251.A0A2T7A167"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="270" mass="30349" checksum="AA5DB70931DB6A1C" modified="2018-07-18" version="1">MTSIDQDRIVYQAPVNRLAWRDTHIYASDSRDTVLGGLWAAEGITHTCLYSMVGILCIFTDTFVLQDDSQRLVERDEQPLQPGNYYIITNGSITITNKVPLLRTLSLYTGTRVQPFFHSVRLRDRRCVITGRPAVINGVYYWDGFEITVLPASGSHGTINSVQNGMLLTRDMHALFASYQFSINPDVCGIAGAHLDQLFLNHPHRPVDELFRWHFRQAVLANMKGIGEPCFETDFPPGSDIMGQIMSGPKAGERMEFELFGRFNAQGICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A256</accession>
    <name>A0A2T7A256_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1121716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A256"/>
    <dbReference type="STRING" id="42251.A0A2T7A256"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 4 C-terminal" evidence="2">
        <location>
            <begin position="302"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="414" mass="44801" checksum="A78880FD40D27C2D" modified="2018-07-18" version="1">MTPATTTRNGHNHKAHDRNPYNSDNGSHNGEDHLLPPPLNVNSCTTVEEIHALLTHLTTQDALRTFLLKQSELEHSLYELRLDVSTPKHTSSGGQRAIKDDALPCGNYCADGETAVSFWLRVGKILQEIIHGEFAEAIVPSVEVSDLPSVTLESAAELLCGLFLREFEHAAGAGDGQNVARLFNLVLPQELGSRDTLGAKRQAAADGAGGLGAFCYVNAVTRLLQHIANRVEPHGKLVERDERSIDGKSYMPSTRGLLGGPPASGSLVPSRSADRNGENANVDVREADILLSEIGPLSFKANHGIMVCFNQVVKSKLRPLLAEAFRDVEYLISPEAGWGALMAPYKRILTEKVFDKLLDATVSYLSKSPEKRRGYAGRISELGAIRLGSDVAVVVDAVVRGGLYRVRDALARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A261</accession>
    <name>A0A2T7A261_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1121741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A261"/>
    <dbReference type="STRING" id="42251.A0A2T7A261"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="184" mass="21102" checksum="BD3FE4B2395D49E2" modified="2018-07-18" version="1">MSPNTDKCIEHFRGFYVSRVGQTWGSWSVEENLGSSYHNRSHLGVIPVYSAPEVLGLDSNNEVSDYTNFADIWSLGCVIYELFVGTKLFISEGQVSRYYFGKWPFPEDTLKRLSPPIDDPGISLLKSMLIMQPEDRPTPADALSHGWLAFLRSDEEDNRDNENERRQTRDESPDREAEKQTSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2L7</accession>
    <name>A0A2T7A2L7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2L7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11768" checksum="C8B59E2F3E90293B" modified="2018-07-18" version="1">MHMPSATHSTPTSAMAKSSTVNSVFLYRNNGGHRSNSAISNPMENSPSKDQHQRPSHARDKERETTSNTTSTCAKAPDTTFREPEHHHHTPSLPPLLVSIPHPPDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2S4</accession>
    <name>A0A2T7A2S4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_969463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2S4"/>
    <dbReference type="STRING" id="42251.A0A2T7A2S4"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU82028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="694" mass="76212" checksum="F3DDBC630DFA5036" modified="2018-07-18" version="1">MPPQVQQVVWPRMSKRPPFNIPVPDVEKKEGEGIPRRHPSSINGLRSRLEPDIATTYDIVKRGAAKFGDAQCLGSRTLIKQHEEVKKLKKVVDGVEREVPKTWIYYELSGYKFLSFKQYLERVNTIGAGLKALGLEKGEKVQIFAATRQVSIFDNLRRCASQSLPIVTAYDSLGQSGLTHSLVQTEAKAIFLDSHLLPQLVNPLKEATGVRYVIYNTDQPVKQEHVDKLKEAHEHLRIISIDELVKLGQENPIEPDPSGPEDLCCIMYTSGSTGTPKGVPLLQKNVIAAVTGVTVITQPYVGPGDCLLAFLPLAHILELVFENACIFWGGTMGYGSSKTISDRSMRNCKGDIQEFRPTVLVGVPAVWETVKKGIMDQVSKQSILTQKLFWGALALKSFLLQTGIPGTAVLDAVVFKKIKAATGGRLKICMSGGGPVAKETQHFISMTLCPMIIGYGSTETSAMGALMDPAEWNINSLGTVPASVEIKLVDFPDAGYFTTNEPEQGEIWIRGDAVATSYFDNEEESKEAFEDGWFKTGDIGEWDKNGHLKIIDRKKNLVKTSNGEYIALEKLESIYRACPLVANICVYADQNKTKPIALIVPVEGPLKKLAAEAGVEGGLEEVVHDDKVRAAVLRELIAAGRQGGLAGIELIEGVVLTEEEWTPQNNLVTSAQKLNRRGILEKYKKEVDRAYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A312</accession>
    <name>A0A2T7A312_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1190606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A312"/>
    <dbReference type="STRING" id="42251.A0A2T7A312"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45456" checksum="742E95D8F9D1A1BF" modified="2018-07-18" version="1">MASRCQLLTQRHDHSWFTEAPSDINTYPSSLMTPSPTLPPHITSRMYALYLLFSTTLHIFLQILLSFLSLPRTLHTHFLHDGARYLKEHYYTPNAFALITGSTDGIGRAFALELADRGWNIILHGRTPARIKPLLEHLREKYPRQTFLPLPIDAAEAGGVSQALQKLGPDISVTLLINNAGALPPVRAFPELSDEEVIDNVAVNVTFGVLIVKALMNGWFARRSCVLAMGSIGAVMTLPGTPTYSASKSYTHKFYACLRTQLSSPHPAFSATTPSPTELEILPIIVGGVRTKMTPISEDGKIFFPAPQEFARHTLAKVGLGREVYGYFWHEVQMWCITIWPEEGGMRGWVNGAMMHGVEKLRAEGWRRLGGGARMVDGRLVGGGRVLRGSMGEMIEMVEVAIVKKIPIIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A332</accession>
    <name>A0A2T7A332_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1075604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A332"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="8454" checksum="F8F9C2DC8CD23F74" modified="2018-07-18" version="1">MQSTKLASRATRPKHRSHNTTLYHRLLVLAYLALLFHCIAQISGHKTSLDTLKFMKKVKGRHGWGDRRVIASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A395</accession>
    <name>A0A2T7A395_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1075498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A395"/>
    <dbReference type="STRING" id="42251.A0A2T7A395"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="408" mass="45813" checksum="4ED81C2F90D469AC" modified="2018-07-18" version="1">MVPQPHSHEASTSSRDSNTRKASVQSLPKPPSTFTWRGGRRYHGDESIHYFLPCDVRELSRQSLFHEVQREVYGGYHCAEFPDDAIPRKVLEIGCGTAIWSASVADSFAARGRPDVQFVGLDIVPVHPDMHGVNFTFVQHNFHNLPLPFSDGEFDYVICREISMVMPVNGVYGSQITDCVRVLKPGGTLELQCSDYLIRSLQRTTAPFIPGSGAYIMTPATQPSMSAENPFIAAWNERITKALTKYQLSPVPCALAGPQLLEEGIIGVRSKRVALPLDEIWWESSPNSDDPRRKRTSMESTSTVDSKNRRSSLSIHRRSSTSVGSNQSQSLHSPLSQEEKAVRELSRLTFVQLIESLEPILRETNNIAMDDWDRWYKDLMINFFQHGGLQGGECVEFGSWWGQKAPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3K4</accession>
    <name>A0A2T7A3K4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000030">
        <property type="protein sequence ID" value="PUU82321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3K4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3K4"/>
    <dbReference type="OrthoDB" id="5288142at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="888" mass="97493" checksum="A9728C680410BA80" modified="2018-07-18" version="1">MSYSALSQKTSYRRRSSIASSTSSDASYRPPQLQLLNFEASSLSHDPESRLEQMENSPTNRVMSMVKSSIRSSTSYEMVGESSDEEGGLRNERGALGNGVTEGSRRADGERDSGDLNRKVDKSFSGMSREDSVGSGVHVSNSHSRSNSASQGVTSSVNNGDHRTELEIAEHDLRLELDLDGRADIGSRQKRDVSEPQTARDAHRPYQPHTGSPRGSRSSHQLPPLPVSTNILDPEDQAFGFTSPEDVHPAFRHSQSYPELPPPPKVDHAREQREYRPATSATNIGDLFEDFDGVHFNLDHPSNQFSVAPPPPPPPKHRKLPSQHSIHPTSPHSHSHSNSQGSSNLVFYPAPVPAMLNLPPTLSKPKPTANNRHSRHIPDNVDLTSNRRSVAYPGAGAPGPPPDKDLHRRSVATLDQAANRRSIANLPPALRASQFFDTPVIPQIEVKEDSAVATLDSILNASAKAPPAAFTDHPITGGAVPYKPNKSRSSMHLGPGPNNNYRNSVAVTVKLHPGESPRSSMEDEAHEDARSHLNPETNEYHDAGNQRRYSGISEDFGPQPDSDVGPGLPTTLLAELESRKAQQRLRNRTAASAFPGGIRSTLLQLDAVAQVQKEARSKKKTHLAWEDPGDMDEDDDQDADVPLGLLYSVTSGAQKRRDDEVPLGLLMKKEMEDAEPLSKRRERLRGQNGHAAQPQPKIFLDVPGLGGGSEASAADADEEVEGETLKDRMKRLKEKKEFGTGTLGMEFASPSEGNSSATKQERAPPAEEETLAQRRRRLQQQEATKRESTLLQQEVRNRRNMMELLHRANNRPQSHYSQAGGNVGHMQPQPQPQMGGLMGGQYNMQMGRGMPMQMPMQMSMPMNMGGTGEVILDPKQREVVERWRASVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Q2</accession>
    <name>A0A2T7A3Q2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_968278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Q2"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Q2"/>
    <dbReference type="OrthoDB" id="20507at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="156"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="671" mass="72908" checksum="D067B75756C92083" modified="2018-07-18" version="1">MSSKRPRAAYEADGSGGSNSNSAPLVAFGTALPALDSETRDDGSYVPVWKQEVTDERGRKRLHGAFTGGFSAGYFNTVGSKEGWAPATFKSSRSARAKAAQARPEDFMDEEDLKEAAEAQIVETTSGFSGIGSTEEELGRRVRQVTLMDLLTPAVQDTMGAKLLKRMGWKEGQGIGPKVRRKAVIDDAVDDTGKTYLFAPTNSAVVMFARKNDSKGLGYAGEDRLQQGKESEIERPVVKEKKRKGGGFGVGVLNDDGEDDEDPYEIRPKSAYNRVIGGEKKAAIVKKPARHIFVSKKVGRSKAAASLLKCHDGRLPLEGFILSTEPVQTQDGWYPPPTVPEGWKPVGLKTSEVRDTKPTTALSSEQKLDPHLRGKLLGEIPLPGKSVFDFLTPAVRDRLANVTGNQNLPPALGEAPPAMYSSSSSSMADLVPKLDKSQALGTLKGGFMPYADDLEKRSRYRAFLEVQAGLREGLPDRKYGMNTQDWVKEMNEFMGAARIFKPLTGMIATRFTSSSSPSSNIQGNTDAPTDPDVLIHRPQEKPEDPAQAAARMSMYGPLTRSVIDFYPSRLLCKRFNVPPPNYSDVPAGAREGSAGPGNRPGPSKELVAKAQITDMMREVKGDDKYELPEVAQKLVVPTVDAERNEALEGERAGEEVFKAIFGDSDNDSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A432</accession>
    <name>A0A2T7A432_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1040719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A432"/>
    <dbReference type="STRING" id="42251.A0A2T7A432"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF76">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU82501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="558" mass="60813" checksum="7C08FE53EA7066A1" modified="2018-07-18" version="1">MAATWAGTPKIRGPSDPVRMVLLTVCLSGVQLVWGIEMAYCTPYLLSLGLTKSLMSLVWNIGPLSGLITQPIVGVIADRSRSRFGRRRPVMVVGAAATAIALISLGWAKEIVGLFFSPGETANTCTILLAILSIYLVDFAINAVQACCRALIVDTLPAPQQQHGNAWASRMVAVGNIAGYFAGTIDLVSIFGASIGDTQFKQLMILASILLMSCILITCFSVEERVLITRRESDKGSGVLQVFALIWKTMWHLPTGIWDMCVVLFWAWIGWFPFMVYSTTFVAEVLKRYDTAARESLETSDDVLGDIARVGSMALVLFSCVSLAASVLLPWVVDSPESRKHVKKHLVPTNFLEQFSQKVAPYKPNLTDTWIFGHITYAVLMFITIFIGRVSSATFCVAFSGVSWALMTWAPFSIVGEEINKLSEPSGTIHRSHGGPYDPVTQREFDHDVQEMETIRASISTDATPMVVDPEAQSHEPSDLAGVYLGIMNVFSCLPQFVSSFISFVVFSILEPGKSPEFSEGGGSEAPTYGINAIAVCMGIGGIATLVAAHFTTRFRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A447</accession>
    <name>A0A2T7A447_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A447"/>
    <dbReference type="OrthoDB" id="5344200at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="12908" checksum="7FDC3ECF6E1DFC94" modified="2018-07-18" version="1">MDNTASTVVVAELEATPPRSKDAATSTEPKDDVKVMVVGSTEHEGLKLLSGTEKSGVNTQIQEEVRQAKMKNPAVLVNLPSSPSAQAYEVTQQAKPDDGYFEPVFTEEEEAAAAAAASKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4L0</accession>
    <name>A0A2T7A4L0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_966985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4L0"/>
    <dbReference type="STRING" id="42251.A0A2T7A4L0"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="117"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="32241" checksum="B60A5B2FD1838133" modified="2018-07-18" version="1">MSTDRSSRRNVHFYDASKPASDALGGLIQNGSVTEANFLHMLGILLAVPAPIYVRHRTSGTIIATTNNPLLIGSYDIYCDAVIKLTEEPWIYRINSSNISGHPDPFRDGIRARDGRCVISGVINPRARITWATFDAAHIFPLGAASLWTESDHGRLVTGIDDTIDITKINSCQNGLMLRKHIHGLFDQYLISVNPDDNYKITVFDDDLDSLDGRILDPICRNPADPNPVSDDLLRWHFRQSVLANMRGVGEPIFESDFPTGIDMVEEIRLGPYAQERLESELASRLRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A574</accession>
    <name>A0A2T7A574_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_280078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A574"/>
    <dbReference type="STRING" id="42251.A0A2T7A574"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="8223" checksum="E3EA535458492D7A" modified="2018-07-18" version="1">MATIRKLKAMPSDPTRYSRADRSVHLFLLISRDDGATDLFPEAFMKKMQIHIAGIGPVFRLGTRWGLRGGVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5F7</accession>
    <name>A0A2T7A5F7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5F7"/>
    <dbReference type="STRING" id="42251.A0A2T7A5F7"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="28466" checksum="F3067C3A4E044968" modified="2018-07-18" version="1">MPSRAIGRNVHIYSAGDISTVLGGLVVTESMTNANFYSIVEITFILDSDYTLRRKKSGTIVQRDNGPLQAGKYLINTAGSLKVNDEPWLVRTRSVVSGAPPQVFINAVRERDHRCVITGQRALSAVYGIWTGYRVTPIFPLAHKQHWATHDLDSSITIPGSRGSIHSVQNGMLLRADVSMLFEAYDLSINPDDGYKIVSFIPGTGGIATTHIDKAFLKDPQRPTDELLRWHFRQAVLANIRGQGELDFDSRSPSSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5L9</accession>
    <name>A0A2T7A5L9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fusaric acid resistance protein-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1119803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5L9"/>
    <dbReference type="STRING" id="42251.A0A2T7A5L9"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="98078" checksum="BE618DDAC4169502" modified="2018-07-18" version="1">MPKSTVASMGLGLKQHLCDVYQVSQRLFKSLLHSSRRNKRAIKVSLSLTMAVAFTLPPLFANFYGTNPFLLGTVAIYLFPLKTIGGQLASTGVGLLGVMCGLGYANLILFLGRLVQSTNAESIGVGRRALLWSAFVFLAIGCGYVRSKYPRAYLAINFTMVVNMFALIRGINHFDPCFSNFFFVMAFGACASLIVCFIFWPEDHSSMLRDDIITSLREAQNVMQSMQHAMKFSFGQEVDITAFKESHVKVSAALEEANYELSLTRVDSAVFVPLNASIARMLSLSRAFNSAMRRRHRLYTRIHFRLNDLVDKELDISTVTFCDGAESNLTNSERALELAFASVSELFCSMTLRIEELYRGKQVVSTIECEKLASKINDIREKLAAEIELRTISGPYELEAAAFTDQVNAVLLDMLEATKDAAQMINCIEKRRISLVLPRKLYTAEESIEEDDSTRRAVSEGDHGLVLLLESTSALDRFRIHLADRLLAFRSSRHVKYGIKFAVVMGLISLPAYISDWHVWYENLRAQWALISAMVVMETTRGMTIRTAGMKLAGALMGGLAAFLVMHMGQGALYVSIALTSLVGLGVGFLVQHPKFSKAGTVLALAYNIILGVATIFPEHGPISSAVARRILTLPVGVMIATFVHLTLFPFRSRSALAKTLSHSLDWLHHLVFAIEASGEFPMLRERFDDMAKKAQRRINFAKNLLPATRYEVSLAGHWPYERFERILEKVVDTMVLVVGENAAEPAISGVIRGGGKLRLKLLASLCNDLLVISHTLSARLFMPRNESLSTYVLHEYQTHLSAKIANEDPSCPDRRNFADLGRLTDLVYEMNLLREEVDELITETQCPKNGLLPHLSFVIKKSRPSTPVGDEEAVGQRVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5S2</accession>
    <name>A0A2T7A5S2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_208777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5S2"/>
    <dbReference type="OrthoDB" id="5488781at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="231" mass="25022" checksum="BA633300BAE13363" modified="2018-07-18" version="1">MPHFIESPVSSNTMTSHSCSHSESTLLGSYILEASEIPKPTITTNATSNDHDPEHTPTTTTTTTTTAAGATTAHLLSYTHLSPNINSSSPSYQTTHYFLRPSSPVSSTSSPTITSPPPTATTNLHNLHQSLLRSHDLDLLLQEQPLVVLMLDERSVQSISIGEFLPGPYFPTEAEEHELGAGTIAQCGYALQRFLNTGMEEEANAVYALSIGGWCQDIRHSKEEGSERVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6N4</accession>
    <name>A0A2T7A6N4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">JAB1/Mov34/MPN/PAD-1 ubiquitin protease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1072752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000013">
        <property type="protein sequence ID" value="PUU83384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6N4"/>
    <dbReference type="STRING" id="42251.A0A2T7A6N4"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="278" mass="31434" checksum="41E1072F62910FD8" modified="2018-07-18" version="1">MEVMGLMLGEFVDDYTVRVVDVFAMPQSGTGVSVEAVDPVFQTKMMDMLRQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVIDPIQSVKGKVVIDAFRLINPQSLMLGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSILINYRKTHLEENMLMNLHKTVWTDGLTMKDFKLLAKENQERLEKMVGLADSYEKRVKEENDLTKDDMKTRYVGKVDPKKHLEELGKRGIEENIVGVLVEMVDKEASFAADIDGSKPGHVEAMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A741</accession>
    <name>A0A2T7A741_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1072091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A741"/>
    <dbReference type="STRING" id="42251.A0A2T7A741"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="517"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU83561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="694" mass="78239" checksum="C6DDD1EC2F80C573" modified="2018-07-18" version="1">MAYENDGTVGPYRAPPMSIKEIADKAVDFDYNPLIPLRYWLRTADTLLKEATIYQAEGNEQQAYLLLVRQAELVFRYLEDHPEAKKQENLRNLRVVRARSTEALKRLEFMKPRITARYEDYKLATQKARDDNYREHRTSASTSHNSRSLSSIPYADAAALSFSQKQSLKASIPKPLDLSRGGRRGSTSSVTGPFSPPLEKSLSSGGLAPSMAASAQLAMEIAKQEFEKREREKRAKRRQLAIEQGRGNVIVDSRGQEIKRISTPASAAVEQSYRNLLSQYQPESQGRDSGYELVGQHSRYPGYYQEVPEESERRLYQQARDEEEHRRRVIEQQEEEWDLARSIEALHMKANLTEGQMQPSSAAANNYRFSTSSTLSGWEEPVRERERENYVGRWQRNYPTVPKRRRSLTRMEPPLIPGPAADLVEIRSVTPTPPPKAPLYSYDGSSNPTPAAPAVPYKKPLPYAHNHAPSPPPPLPKFPSSSTATTPTATKHVPATPEGFQFSTPATLENGTPLRTIFLPATLRQQFLLMAEPNTNRNLETCGILCGTLVQNALFVSRLVIPEQEATSDTCSTKDEEGLFEYVDREDLMVLGWIHTHPTQTCFMSSVDLHTHCSYQLMLTESIAIVCAPRHQPSWGVFRLTNPPGIEAIKTCRQDSLFHPHGELNVYTDAMRPGHVCEVREMGFDLVDLRKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7B2</accession>
    <name>A0A2T7A7B2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_823186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7B2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="10973" checksum="15B37A49B4711D8A" modified="2018-07-18" version="1">MEDGCIDGWVRYRYSILESVGVFCSCIANVVGLVSFEAETFSFPPFLFLSHLTLFPTVRKCSMSFGCLEWFCFFSLFTFGFLLSCPCETARWSRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7C3</accession>
    <name>A0A2T7A7C3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1105088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7C3"/>
    <dbReference type="STRING" id="42251.A0A2T7A7C3"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46017" checksum="165E0C2D4602F9B7" modified="2018-07-18" version="1">MDTQANTPLLLPAPTRYPPPYLFILDLCVLVSNLPYLLGIVLPLRTSNPYAELYPYSWGNITSLTLGILLIIVGLLSLLLIPAWLFLPGGVWLCWFAGVAGVTWALSRALNGHEGDVVVSSGQYVRGKAELEDEKWFYVNGVMTGEYWLKTNVDEAERRFGRRIWGCLVQRDLRYSSACVRSLYNNLRTALLELESKPYPSSSSSPSSSIPVCRPKYKRVVLLAHSQGALITSLVLDMLYADIPASLLSCLEVYTFGNASNTFNNPLSQADNPNSGTLRHLEHYANRGEYVSRIGILAFMPGGDVGQALQTWGNQFAGRVFVREGRGHLFVQHYLDVLFEGGFVEVGGGGGVGRLLGYRDGAVVPNSILYSTPLRQRLVIHPATELALLSNEVTTKEASVFKESIFQKCWSSFSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7W2</accession>
    <name>A0A2T7A7W2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RGS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1060719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7W2"/>
    <dbReference type="STRING" id="42251.A0A2T7A7W2"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="164"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="350" mass="39253" checksum="E78FF33B0B551903" modified="2018-07-18" version="1">MATVGDRNRLPTLFEVLSRRTLPPVDLFSFYIYMRDQQRSVDYLDFWLDVAQHISLCRHYVRELRRSVLVSTPDLDKGSKRSSGAPEDLLGDGDYEQKSDEQRLSAFLRSESTSESPARRSMGDTLGTPGTGRPSFMSSSALDPNTDSTSPGHTVTRADLRASAEKILYTFLLRGAEREIVLPEVILQSISNAIEVEGRDDPAIFDEAKDYVFQAMERDAFPGFLTAKALGNLVPPSATIRLIVGLLAMFGGFWAAFALIFLDIKPKVTRLWLILPFSVGVYCLMAHQYSLDPIMGLIGFSEYTLMSFTRVKEPYVRRLLSKRSLWILALTIVMVAALVCLYVFVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7Y5</accession>
    <name>A0A2T7A7Y5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Senescence-associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_962241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7Y5"/>
    <dbReference type="STRING" id="42251.A0A2T7A7Y5"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="72"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="379" mass="39403" checksum="14F1E9F38256DDEB" modified="2018-07-18" version="1" fragment="single">GRLVLIDEENGHEVGEVGGYQVHAIGVQPGSKEPVEVSLPEDGSGRKYILTPTQVRPADYLKDALDPAYRNSTIVGTAATASRLIVTTSSYIANAIQSGADTFTKKTRPNETPLTFNPSTHNRVRQIHTLSSSAAKLSAQAVGQVSKHAQNLGARIVGRSEKGRPANPGLLNKSLVAYSTIADGIDYASKSLLASSSNAATTMVGHKYGEEAREVAYGLTGSVKNVGLVYVDASGVSRRAVVKGVAKGMVVGKVRGGGDVIVPGHNEVIDGIPKGWGDGHLGGPHAGPPSRNPSIHTPGNRSPPAPPPSYHSGNGASSGQRGDNLYFPPPPGSGGMSPQLTGSVYRSSSPGDSSLRSVSPRPFDEKADSNSNMHGGYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A829</accession>
    <name>A0A2T7A829_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1071446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A829"/>
    <dbReference type="STRING" id="42251.A0A2T7A829"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="19858" checksum="9AF174F139F9B296" modified="2018-07-18" version="1">MIIYKDIFGGDEMISDAFDMTLSQDVVYEVDCKFITVGKGADVDIGANASAEEQAETLEDGQESVNDVIFSFRLVQTSFDRKSYFAYLKGYMKRVKEHLTQNGASPEEIKAFEDGAKKFVESRLTSQSFKDAQWEFYIGESMDVNGMIVLLNYREDGKTPYMVFWKHGLKEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8I5</accession>
    <name>A0A2T7A8I5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1060466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8I5"/>
    <dbReference type="STRING" id="42251.A0A2T7A8I5"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000058">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000027">
        <property type="entry name" value="Calmodulin (CaM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU84048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="16983" checksum="993E14EA2C563ADA" modified="2018-07-18" version="1">MADSLSEEQVSEFKEAFSLFDKDGDGQITTKELGTVMRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8L6</accession>
    <name>A0A2T7A8L6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1098323</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8L6"/>
    <dbReference type="STRING" id="42251.A0A2T7A8L6"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU84078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="785" mass="87864" checksum="A8A6BE667C900081" modified="2018-07-18" version="1">MTPSTPQPHVIAYFRSLVWQSLDNDMLPTALFAAERLSAYDPKGGDSVHLLSLCLYRDGQYLAAESLTKSWVVRHLGCAYIYAQCCLKLGDGRESQGINALEACRRYWIGTSTWDRHSDTDRRSIPDAATVHFLLGRLWHNTGDVKKSVDSYVAALKLNPFAWEAFTGLCDTGILSRANDRLGVNLRPNAVFKQSQEMLESLKIPSYPSHPSNIPPTIPEESSTLNGLRNSSENLPSDPFSANGGSSRDRSDLSFNNHPSFFNRLNEGVGSGLEAETPTSQPTGSSSHELFGGNGLNTADKPPPVRKTRATTTEVTTRKLTSRSTREVGNDGKRSAASSQESGPQAPARRSTRLTSKFTSKLGVGAERETRLGTKEREREAKKAKTVASRSRSLHLTGASAAAKERQKERERDTSEDINMSDAASKPTFAPGHQIDIKKQEAQLFMLDLFKKAGAGYFSLSRFRCKEALHALNSLSLSQKDTPWVQSQIGRAHYEMANYVEAEKCFLRVRNLSPVRTRDMEVFSTILWHQRKEVDLSYLAHELVELDRLSPEAWCALGNCFSLQRDHDQALKCFKRATQLNPKLAYAFTLQGHEHVSNEEYEKALASYRSAITADSRHYNAWYGLGKVFEKMGKFDTAEKHFRTASKINPTNAVLVCCVGMVMEKNKDFRGALHQYNIACEMSPTSALSRFKKARTLMLLKSYQPALKELRILKDLAPDEANVHYLLGRLHKLLHDKKSAIKHFTIALNLDPKAGHLIKEAIENLDEDEDDEYSGDAEENRFLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A910</accession>
    <name>A0A2T7A910_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1070452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A910"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="21524" checksum="1BE01D206A89094F" modified="2018-07-18" version="1">MGCGLHLPSRRRRCLRGESQRGGPGRSCCCSHRGGRCGSPGGKAGGGSSAVILRERGVVSIGGLVAVGRNGGPRPELRLGLETFRALVLYCIAYRIVWFKGRHQILTRLSARIPGRNSAARVYYRQKKKKIPRSSTENYITAQHKCPLPCHHQPARILILHPMMLLSSFFKGFAKTARCLRLNGAWRLKPALSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A973</accession>
    <name>A0A2T7A973_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1104661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A973"/>
    <dbReference type="OrthoDB" id="2935572at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="608" mass="67459" checksum="8B895ED89A17AA90" modified="2018-07-18" version="1">MSSWSSSASPSKPTVMDSNLPSFNDIFIKAMASSSAPYPDFTANYEMSLAAIFADFPEKPKDFGDVNHILSKTAKMIFDATDSSALIDGVETYRKIADRCLDCIKGLTDNLNLSAHEIKDCWARSSRFEQEAEENSQKLQTAKHALDHQVKHIESITHACFAQDVILKEYMSKHEHDKNNYRWLTELKDLYNKLEADHKHCEQRFKAFGEMLKDNEELKKEVQDLKIENARLTVENYTHEAAADLDEKSAIQKSSERFPKAYSVNVDFPGHLSIVEGVGSSGSPEALLSMTIGLKRTDPGAAKLPGTDKQKGKWKNGMDTPSLQVSREAPGVHSTASEANSKSSADAAGVSQRMPRILKSMPLTSEEAPNTSGAISKKKLKEPKETPEDTSRKDGSSGKFIASQTPESRCVVLTNFPQGTKASDFCRIVRGGRVEQILVEVHFGKPMALIYFFHERHALAFHEWVLKSPRLHINNVPVDSKLLEVRKAASVSVAEESRVIRACLNPGVGRIELIQEFSRLAPKLNIPPTSLQTIDMTEATNGTVWADYAFDGRIDAKKFLNGIMDRRVNMQGATYGKDQCEGPFHQGVQAKNWHVGSNKPADQGATKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9A4</accession>
    <name>A0A2T7A9A4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9A4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="207" mass="23659" checksum="555A32C4D3DD332C" modified="2018-07-18" version="1">MIIFHYRQTKGSDTLFLFLCDSNPTPVFFPSFLPFFDHISAVECHFDRFVFIFFFHQVFPPGLCCVRSPRKLYPYPSVSWSPSPFFFFSPNYSPSLPPSLLPPSSLRSSFAPTFSHTCSLSLDLLSWFSVEFRDFKKNYHHSTPKSFLSSRQLLSVTLPSPSVIAVVSHTETLFPSVFFVNPQTPSPSIKNYSASLQVKYFSLPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9I9</accession>
    <name>A0A2T7A9I9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1070186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9I9"/>
    <dbReference type="STRING" id="42251.A0A2T7A9I9"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="164"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU84362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="259" mass="28356" checksum="BB986B628CF02DF9" modified="2018-07-18" version="1">MPAPTALQKPETVAEPVLENIAVPTDDDDVLIDSFASSTQPGDTVVVAQTPKDVGDGMQIDEEGRPKFKPAGASKIFQKGENRKIPIPPHRMTPLKSAWPKIYPPLVEHLKLQVRMNLKTKAIELRASKETTDTGALQKGADFIRAFALGFDTDDAIALLRLDDLYIETFEIKDVKTLVGEHLGRAIGRIAGKDGKTKFAIENTTKTRIVLADSKIHILGGFQNIRIAREAVVSLILGSPPGKVYGNLRTVAARQKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9S2</accession>
    <name>A0A2T6Z9S2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000628">
        <property type="protein sequence ID" value="PUU72233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9S2"/>
    <dbReference type="OrthoDB" id="5483538at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="393" mass="45204" checksum="4ADAD3504F8E54BA" modified="2018-07-18" version="1">MSTTISKFHLLNTTLEIEKYTMENNTDRYWDFEKRKVIMFKNVITKFAYDEIGIIINSGYDFIKDGKNTDFAIIFDPRENTLDYVRRWWYKFSRCEAVGIRGTKLELASISDYNNLKDCIRKKWLLITGPNWSGIENYHQEVISSRVAYSAIAAMNYSEGQGQYTIESSHQVNPLIISQQSSAIHLSTTSQSSLHHLPDHISLSSLSPTALVNQSVSLKQTITEAIPSPCPIPPSSIFRTFSQSDWPDCLKSNNICDFSTSSIEPIGLTTEKKEEVIDDVRKLDYTQDLLSSMRAKLEFSFYLRNHDLKVVDQTSNILKEGETIISRIEYEKLLDSKLKLSKELESLTAGNVGLEQRIEAMEKEDKNWKMKEESEKMESLKLVEDLRNIIFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9S7</accession>
    <name>A0A2T6Z9S7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1011569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000618">
        <property type="protein sequence ID" value="PUU72248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9S7"/>
    <dbReference type="OrthoDB" id="5290812at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="267" mass="31260" checksum="FC47CCB29F0A79C3" modified="2018-07-18" version="1">MGCLKEHTTTISKFRGLGLDITTNPPKSSTQEVYNMNIGRKISVTFYWKFDIESLCIAQFGIGLAHLQRRKEEEKLAKEAAKKTNPSPLRKLRDQAKSTIAESVWTIWNGEDYKYPRERWGKDVTKEQLLAWLFLRQEDEEPQNANITGTLHRYLKTIRGKATLASKDEAWFDSVARNLLEGLKDRDSAEDGYRALALSWHTQRITDIFEQLLSAMPTHHHHYHCWYEHPNGRTTHRHELRNFLLHMEVEHPVFYWSSEEWEGVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9Z3</accession>
    <name>A0A2T6Z9Z3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_952293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000575">
        <property type="protein sequence ID" value="PUU72321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9Z3"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9Z3"/>
    <dbReference type="OrthoDB" id="5289248at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34615:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="19030" checksum="64C3FBF40CDEAC38" modified="2018-07-18" version="1" fragment="single">LKSLTNNDVYHLTRFTLQDLKRTSRLLDLPPTFSTPSGARLSDEEAFFLLLCRLAWPTRLETLAIFFPYSPGTISEAVNWILLFIYQNWDFLLHDFNSQLASKHLSTTKLDLFACKIYAKGAPLKACWGFIDWTIREICRLTRWQKECYNGYKHMHAVKYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA08</accession>
    <name>A0A2T6ZA08_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1059988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000604">
        <property type="protein sequence ID" value="PUU72276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA08"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU72276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="326" mass="35173" checksum="550B749A6CEA510B" modified="2018-07-18" version="1">MTTAPPLPPPSNPLSFPPATFQKLAPKTFLERHLQSTPATRPSGRNPDTFRTPSLHTNSLSHAHGSAVVRTGDTAVVCGVRGEILSLATGVGSRVVVLRSGEDGKEEEGDGIRERGLVVTNLEMGTGCTRDYHPGPPTDFAQAITARLHRLLLASKLISSQSLRILDPNTEKIKAYWVLYIDVVVISLDGNVLDVAWASILAALRSTRLPQAYWDQDAESVVCYPEVSRYKSLDIKGLAFIASFAVIDLGAEKGGKVILSDPDEFEEGVCEERVMVCALGGGKVGWIEKGGGVGQVAEVVECVHRATERFKVWEQLFVEVLGSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA13</accession>
    <name>A0A2T6ZA13_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1137928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000566">
        <property type="protein sequence ID" value="PUU72341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA13"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015681599" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="7">
        <location>
            <begin position="76"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="160" mass="17469" checksum="1A9C42D60778C0D7" modified="2018-07-18" version="1">MFSLLFAILIVPSLLPSTLCVPHGVWETILPPGTSPPGCIDSYPGPFSFQPVDHPTPGIETHCMKPRTLRAVLQHGVLTDHLGRIGSIGANRQFQYDGPPAQAGAIYTGGWSLCPDNLIALGPQKQFYGCACGDKEYHYDMKIADYCRPIFLKIVLLVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA38</accession>
    <name>A0A2T6ZA38_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1010676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000563">
        <property type="protein sequence ID" value="PUU72358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA38"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA38"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17466" checksum="5472513CA98E3006" modified="2018-07-18" version="1">MSSATTFYDLEPLDSRSQPYNFSQLKGKVVLIVNVASKYQYEGLEKLYEKYKDEGLEVLGFPCNQVNYGVKFPVLAKIDVNGDDASPVYKWLKNEKAGLLGIKLMQIMSNTCLEKFLVSREGRVVERYASTTKPESLASAIEKELKKDTPPKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB45</accession>
    <name>A0A2T6ZB45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1008495</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000477">
        <property type="protein sequence ID" value="PUU72722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB45"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB45"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="179"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU72722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="779" mass="86529" checksum="09F59C5910454760" modified="2018-07-18" version="1">MGGKRQKHRAGNNSGGGRNRGNNNQGTGERGNYASIPTENALYESYYNQSGLIPSEEWNDFWTSLQKTLPTTFRFTGGKAHALGVLKTLKETLIPHLVGIEWEGVPVEAPRALGWFPDSLAWQLSVGKSTIRRCPPFKKFQNFLVAETTVGNISRQEAVSMIPPLVMDIQPHHIVLDMCAAPGSKTAQLIEAIHANEETRVQAAIQDESIDDGSGGRPAGLVIANDADYRRSHMLIHQTKRLNSPNLIVTNHDATMYPSLLVKNEDGRKEYLKFDRILADVPCSGDGTARKNYNVWRDWNPLGAIGLHLTQVRILVRGLQMLKVGGRIVYSTCSMNPIENEAVVAAAIDRCGGLERVNILDCSDRLPELKRRPGVKGGWRVMDKDGSWFSSFEQVDKADMREARLSRIVPSMFPSEDEKSDEDESRVPLERCMRVYPHLQDTGGFFITVLEKRAEIGAVKSEEHGRRKMAAIARSKVGTSSEGGKGAEVEETLEGVELVPTTTTSEGETPTPGSPSKRKLTEAVSNTTPPALKKLRSDLPDTNGDDNSDGGVQLGDEETTLGTRTRPTAPSPPKKSKGPPAEEPFKYLPTDHPVLESITKFYDLSPRFPKTCFMVRNTEGIPSRAIYFTNHLAKQVLTSNEGSNVKFVHCGVKAFMKQDVQEEGVCPWRIQSEGLSILEGWIGETRVVRARKRETVRGLLKELFPKVHAEGQEGDVIREIEERVRGLTMGCCVLKVEPTEGEFEDRMVFPLWKSRHSCNLMLPKDERKYEPPCYCDAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBC0</accession>
    <name>A0A2T6ZBC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1136901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000478">
        <property type="protein sequence ID" value="PUU72714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBC0"/>
    <dbReference type="OrthoDB" id="5319158at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="351" mass="38828" checksum="69E894C92FB59DDC" modified="2018-07-18" version="1">MDAIAEVTVFVVDITAKTDIHKPPPGRNGNQGPPRSRPHSYLCGGVRGAVHIQLLNLNGTEAIYPSQYDILAVGLEVVDKNGSEINESGERILVPNIYISKVLRDEAVGVPGVLCAFIQQERFPHQMGVKLLATAETKLTGVMPGIDRVLPDFCSFMTINISYLLELEVPRFFNSLKNVNIKLYRICDSLEWSAAGSSRDLDFLDTLDPGTAATIPQMFRLSDWAELYSTGSMTRKSVPLEPGDNQDFCEEVIHQICGCVADLSLLLDIWNMSVCGNFQDPNCPIVADAEHLFYNYMSKSIDAPANPFEYFQRGVRTAFDLLDSEVVSYMTTVGTQFPFPEAVMSSPTRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBJ6</accession>
    <name>A0A2T6ZBJ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000451">
        <property type="protein sequence ID" value="PUU72865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBJ6"/>
    <dbReference type="OrthoDB" id="5387493at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="306" mass="34224" checksum="66F71A250CD64803" modified="2018-07-18" version="1">MKIPTIQYGIPRSTDTISTPSLPIDSRTMPPIPRFLLPRPFLPSRPSRIFTRNPFCLTRNASTNSKKLKKRAPDKNIKTTSPLSQTGKHFSLIESLGNSNCPAITLYTCHNRKFLLSCYGLSSAMLAWSCYTYHTNIANSRPGLPAWVTKVSWGSIAIMTGMAVAVAYFPTRLIHTIYAHPIPATVSRSASISLTLHRRPILPILPMKRLRVASPGMVTLEEPISPAIRSMAKPVVAEDKRAGWQKVWGKISPTKIFARAMNDISTSGFILMKVEGLGSYRIHKDGWVWERRGLDRIFKVRNAVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBW0</accession>
    <name>A0A2T6ZBW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000431">
        <property type="protein sequence ID" value="PUU72987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBW0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="63" mass="7539" checksum="5AA3C9F56F6FA230" modified="2018-07-18" version="1">MHTKPNSPKHQRHSNPRTQPFMNPLPNCQPIPQNRKQEGQRINNRDHHPPNQQEKLSRINRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCD4</accession>
    <name>A0A2T6ZCD4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_578784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000417">
        <property type="protein sequence ID" value="PUU73074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCD4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="17407" checksum="8C6E049E0259376D" modified="2018-07-18" version="1">MEEKIEIKNLTSPVGAAAPSPIARSSFLVASRPQLALASCTATQRFSLSPSSSLPCPPLLPSPFSFLFLSFSLAATLLFVPAPVPISASFFSHSEPLPLSRFPLSLSLSPSLPLSLSLNLSPSLSQIKRRNEKQLSTSCWSPHGKHRTFFRVESTTILDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCG9</accession>
    <name>A0A2T6ZCG9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_570904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000408">
        <property type="protein sequence ID" value="PUU73159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCG9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="143"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="476"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="574" mass="63738" checksum="DCEFD6A70F3B32CE" modified="2018-07-18" version="1">MSKLRKIVRRTLFSRRRDDGIELGREEKSKLHSGVGDKVCIKKPWEPVYGMHVLNPERTEVNVDIIAVHGLGGHAFRSWIHEATGEMWLRDFLPRQVPRARVATFGYDARVARSRAVVELLDSAQSLLLDVKLLRSAPEEQERPLVLIGHSLGGIVIKKALVLAQQQADSHSILHKMCCVVFLGVPHLGSSVANTAETLVRIAQIFGDFNTRHLEELKKESPSLRDLAQAFGQLEGFKIITVTEGLETAIPFTNKSVHVVPQSSASLHMGGRETVVSIDGADHHMISKFGDSEDGQYGRIWKSINRFLAEWEFKYRVPINGPPTPPLQNTRALRTTEFLPVESPVPSPSGYTPPITPEQPEQFSFLTRRRMPTPPIELEDLIARRPLLYPSQASPPAPPLLLRQPTYSLSLSRSSTLPVTSSPFPLSRTSTALTIPSLSSPTSQTLHKAIRERNIPLAKHVLEQTSGDGVNSVNVQGRYPLSIAAAMGDEDLVRLLLSWGADIHARDDMGRTALHRAAGCGMTKVIKILLEKGANMEVRDFTERTALEWADKEEVRRLLRGPPEIGIEVEEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCH5</accession>
    <name>A0A2T6ZCH5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1095598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000403">
        <property type="protein sequence ID" value="PUU73195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCH5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCH5"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="523" mass="57539" checksum="A0BECFD4F5B85ED4" modified="2018-07-18" version="1">MTAVIKKLFPGKDSSAPHEASSFRVIPRAAPPKPDNSPRILIIGAGSRGRAYARSIVTATNGTVVGVAEPDEYKRRRLVQECNISDELVFTSWTELVGEHRGLVMSRVDGVCVCTLDETHEEIVLAIRPLNLHIMCEKPLSTTLESCVRMVNTISDPDLPPILLAVGHVLRYSPHNILMKKLVCEDKLLGEIVNVNHTEPVGWYHFAHSYVRGNWRKKETSAPSLLTKCCHDIDLLLWLLCSPTATATPHLPSTVSSSGSLVHFRHARKPAKAGNSTNCLTCPADPGCIFSARKIYVEKNLKKMNMGWPVKIVVPDIEEANNMDAAEAMLTQKLGEDYGSEGTMVDGEQKSYYGRCVYEAGNNVVDNQVVTISWDDDDASTSPCGALAEGRGAKTATLTMVAFSEKICERFTRIYGTKGELEADSNQIKIYDFETGVKTTWAPSIDMLSGHGGGDNGLARAFVDAIDKVKNEEWAVGKAQEEIVGVTIEEVLRSHAAVFWAEEARVNRQVLGWGEWWTQNVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCW3</accession>
    <name>A0A2T6ZCW3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Proteasome activator subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1095287</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000388">
        <property type="protein sequence ID" value="PUU73313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCW3"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="12">
        <location>
            <begin position="375"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="14">
        <location>
            <begin position="1365"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="11">
        <location>
            <begin position="1865"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="924"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1219"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="942"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU73313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1953" mass="221453" checksum="DF86E802966814BE" modified="2018-07-18" version="1">MSKVSEFLAAHLGANGNDQAASGATSPGAEWRDDDDGDVAARYRPRTYPYYRHLPYNTEDESERQKNLDEIIKHLYISIEAGDFAPGAVHWSRELRSWLSLKFDPPRKTRVKLVKLYYELAMAPGLDPTVAERFASMFMVLTKRKHYLRPGKDLTLDWRPLFKELKVFVLPQESGFIHSTTVKKNVRTLTKMCSFAQPFFNPEEITEMFEEFLPYFSTSFAEGAFVVVGLLNLLLPTVPPPPDKLKLQPSYYLPTLFHLWSLVNRSRVFDVNFLDLLSRLARDLLPAKSIPFREYGIYSKEQSALIFTAILRLLEIPVGQATSPYSSVVDTNIGLAMTLDRDPRKNPVAHHIARWIVMSLSPYSLNEPDSILSNLEGLIQAVETFFHPSNTGNWTKTLSQLVYYLADFFVMRWNRERSGEMDVPEDRRLTPELKRRFVMCLKEVIFMGIYAKSSTAMSFSLSSLQSLAYLEPDLILPGALQRIYPSMQGLVEVHRTTSSLRSLQVLSRIMVRTRGFRNHVTTLLGLALPGIDANDLDKTLHTLSFVQAVAYNIPFRDLTEDEEGGGSGSHLALEWVGSEVERLEREGAEVMIDYNTELSDENEAAILRSSTAGLCEFLISFLGRVFTLLENLPDASRVRSGSPEDHIANTLPAAFTPLLAALSPELYDIALQKITDFVSSHVIHQARDAMAFICNSLCKVNPEKALKQLIPVLIRNIRTEIEENGAASTRNTGSDVLPRDRGLVWNVSILSMCVVHIGDAVLNHREELLEIAGFMQKRCKGMPTVHISNFIHHLLLNLTVVYTVDYGLVEPGKRCDIDAWGKVYDPKKLTIRWHIPSREEVEFAVELFRSQAENALEALASLTSGSSDIKSDGTGKEWSDEVSRNLVLLRLIISGISVLFDPQRIPGGTLVEKEKRDDDLEMKDIDGETEDAPGIEASGADGSDEPMGEAQDDDVKPTYRYPAGYFFDDPEDPLYITVHALRDKVGEILHSVHTFLTSSQEDDVPCFNALYTAYRSWFMDVGIERSACVLDRVTRLFAADIHPFKVSGMRKNYPRPLLLRRANVYHLQRLRHNAGPRPQSVMDKTLLLDLAESCVSLYTEIRRHAQSAGESATKVIIGARPLVIPPLLTAFEDSIKNNDFRRMKGAMYSLLFGSLAKTAGRDWRYTPALIKAFIAASTADKPSVQKLATSATYQVMDYGRPLERMVILNDETVRRIAPAEDLLAVIAKKRDQIARKRKRIEAKKHDLALELVELAKEAHWKTASRAATIVVNLGLRFQTIAPSSMLELTTKGTVDAHPGLRGLYSGALVAYFCLIELRATCDHNYRNFLLDRLSLPNKINVPTRSDDPKWTSKFLDAFTKPEAEYYVDHDYPGWFVWGKDFPAYEVNPKEGLQFDEVETNARKTIANLLDREWFKSFFGYLKQEPRDGSPDRFRMASSMLLQFAFELVRDGLTSVTYDQLKEETEAVFEDGSDKHQHRATAEILGALVNAYRDSTAKNRDMMWAHVFPIVKRIFEEGLTPENSSYWSSFLHLVLQGKDLRRSWPIMEWLTNYRLDMNSNAAFKESSKIQLLQQSIQEAGWHFRLEKPILEDFLKHIDHPYKGVREAMGQTLGTIYRSRHHESYKNVQCLMDTQAKASSVGLTPYNPTEEFSETVHSVFKRLEQWRHERTPGQQSPSSYTAGSKTVLLWLDTTLSSHECTQLIPFFPDVFMGEMLHMMDIKEDPELMSLAYHVFRHLPNIPHPFNQDHEFVSALIRIGTTSPLWHQRLRVLINMQVIYFRRLFLITAEEKERIFTCVSTMLEDPQLEVRIGAATTLSGMVRCSPVRLREGIVQELKNKFTRMLVRNPLPKRSPAGTPTPDYTRIVITRHAAVLGLGALVQAFPYASPPPLWLPEVLATLAVKAAADPGMVGKSVKSALGEFKKTRQDTWHVDVKAFTSDQLEDLEGVLWKSYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE54</accession>
    <name>A0A2T6ZE54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1094467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000349">
        <property type="protein sequence ID" value="PUU73726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE54"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015487419" evidence="2">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="242" mass="26818" checksum="F21FDAD97D2BB681" modified="2018-07-18" version="1">MFPSRFLFPVLFSTAVLGNIEKEIFVAPSNSQDLLFNGTNSPQSAGFEALHPGLLRLSPSPSCEGTCHELHVTLDTSFIGSGESHWAVLDHLEQGKRYEVRICWAATSPTDLTLNIYTASQLLDKPSLLANMTAYATHQLPPSPVNKLSCPSAAPRSVLYLNIRAKAGYYTHEKHRMETPDPVRVEIVLDPFILNALPESLLPIAVTIILTALSAFWLSGRVYNILRNIASLKQSRYDKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE76</accession>
    <name>A0A2T6ZE76_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1094397</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE76"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE76"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="9665" checksum="1D3B3E7DBDD6A549" modified="2018-07-18" version="1">MRVAAMGSFIHACEGEIVCQSINTKIPYFNAPIYLENKSQIGKVDEILGPLNQVFFTIKPQEGIVASSFKEGDKFYIGGDKLLPLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEY0</accession>
    <name>A0A2T6ZEY0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_486721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000325">
        <property type="protein sequence ID" value="PUU74051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEY0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEY0"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14506" checksum="4BEF3A75AD885269" modified="2018-07-18" version="1">MFCLPRVANWPLKVNSLNSPRNCWRSTTFMGEVMHNIRLGSKCNCTLFNNPLDENLYGSPLFYYEHRYITLKDDLKKGYAYGVYPRNLHGQGILLCEKSLTWRIIGGMVHLTFYSGPTPADVLPIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFE4</accession>
    <name>A0A2T6ZFE4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1159715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000317">
        <property type="protein sequence ID" value="PUU74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFE4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFE4"/>
    <dbReference type="OrthoDB" id="5414761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="302" mass="33905" checksum="F59456E77B2602B9" modified="2018-07-18" version="1">MYRIGASWCPARNIYLEGCGKHGTNSRNLVPTRLTVPWHPELERIASTLSSSTQAKPPSMLPLINRLFVFRVGRKPFHPSITAARLAHTGSSRYTMLPTNRNITQPLSFGADRHASLIRKGPQEENRRDLCDYTHNFVIDSEEDMVDTTDIKGEIMRFIAAKTGTPYLSNVPMAEAKKVLRKCPGFIYGSKGRAIVPSPVSYGAEARWIYFILLRRFRSTYLSTKASEALGLKQDGESMVTIAGQPSPVFRAPQDSPISNINVLGTDFLDMNNVKKVENYGTDRVQLFFSELDEQDAVFDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGJ4</accession>
    <name>A0A2T6ZGJ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1068113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000291">
        <property type="protein sequence ID" value="PUU74576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGJ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGJ4"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="3">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="758"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="411"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="966" mass="104636" checksum="474B26A88C3FF461" modified="2018-07-18" version="1">MNTGSNGNIPRSALSPVSVAGSDWSGISGYQNRGSDQLYGGPPPRSGSLANGDGMGPPGQRQNVSPPSSVARSSDGTGLYAQSDASSLQDIIHEEEVAAHHSALRKLLQPYLSQPGNSRPNKARDKLLRLSVVQFQELSTDVYDELQRREGVDASSGPNDKPPPYLLPKEKFHPKRNQARQKLSSLAATRFRDLATDVFFELERRYPKYATELTRERSPTNSVDGRGMAPPGRLGSPGPGRVGSPGPPGRMGSPGPGQMRGPPGSSPGPYGPGPNGLPRMGPGGPPRNGPPGGLGPPGMEGGGSPNRGDAPNSFGRPLPKTFQPGTVIPNKSTMVEDEDDDDDDEGGAFGLEDSNRKPNGNRSGPTSPGRDSNRSMGSMGSMINGGNSEVDKKLIAEYQSKVEILHDKVAGLEASLEDKDQEIAKVKDEAKRKESDHNRDRREWENLKRDLEEKLANAENLNRNVQNELSDVKADKSANEGSLKDQLGDSQQTVASASDRKYQDLLKQHEELKMELREQEEVTEEVRREAMEFLSQMKSISERADHSFEREERLTSEIEKLQNELREWKTRYARTKATLRSLRTSSMGLALQSPTSLISKEGGLSDPNGLVKDVHVTKFQISIDELLRTARGANYSQTLEYVKAVVMATRSITEGIGESKTHNDDRLKLKSRVSATANNLTTAAKNHATGGGLSPVSLVDAAASHLTASIVELIKIVKIRPTPQGDLEDDGEDMIISPASAYEMDRAAGVGIVAQKTNGAAKGQSGSRLSGDSVYSPLSSPEHSRDRSRNESPGGKDQWGSQPSSARSPAFADRTVGSNFEELRILLETQMVGIVESIQLLLTSIRAGDDMQTLRKHVDHITPVVWKVLQSTENSMQQPGNETLRDPGDWIVANLSKCLQSMGDMSNEGEPIDGPADKEFKARLASLAFDLVREAKELVRAVEVTENKSRGGAQVMGHPMDEDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGN8</accession>
    <name>A0A2T6ZGN8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_419311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000282">
        <property type="protein sequence ID" value="PUU74660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGN8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="18811" checksum="2D8C00F12F1FEE2D" modified="2018-07-18" version="1">MSRFFTKQAHVTFLLAAKQPPRYRFPTLELNRLANVRTMSKATDDAKPINNLTPQEAERLRKRARRSDNHVGTLGASDDFSINVIEDQCSFGANMPESSVEPRPDMAKHNSDGAEGEPNVAKHSSYETGWGSDAANNTSDGGGWGSSGGGWGSSGGGSGSDVGGSGYSGGGCDYSSGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH77</accession>
    <name>A0A2T6ZH77_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1091749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000269">
        <property type="protein sequence ID" value="PUU74829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH77"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH77"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000005">
        <property type="entry name" value="Gtr1 g domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="39939" checksum="91928E90766AC559" modified="2018-07-18" version="1">MSRSQALQSPTSSVGTYPGMGQASTRRPRLLLMGQRRSGKSSISSVVFHKMPPTETLFLEATTRIQKDPIHSFMDFQVWDFPGQLNFLDPTFDFDHIFGELGALIWVIDAQDEYLEPLSKLHSTILAIQRFYPAINIEVFVHKVDGLSDEYKLDTQRDIMQRTQDELSDNGLDNVQVSYYLTSIYDHSIFEAFSKVIQKLIPQLGTLENLLNILCSNSGIEKAFLFDVLSKIYIATDSSPVDMQSYEICSDYIDVIVDVSEIYGYDRKPQGQISSPTSEAPGEAQQEEEEAPLEASSIIRLQNGMVLYLREINKYLALICLMRKDSIEKQGLVDFNVQVFQNALQQVFEVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHL8</accession>
    <name>A0A2T6ZHL8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1103169</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000257">
        <property type="protein sequence ID" value="PUU74981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHL8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHL8"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="363" mass="40082" checksum="3C63B64363DB7ECD" modified="2018-07-18" version="1">MPSEKKIKERSLPSQKNPLLQGADIPPYNELVDMRRLGQTNLGNKGGNDAVLFSYVHLRAPLPQPLEGSEIFGSVAPESYFLMRRSQDGYVSSTGMFKASFPWAKKKEEDHERQYVREHFEKTSSDETAGNLWIHPTDALALADDYGMRLWIEALLDNDTAPAPRRRSTRSASPSKRLGSTPRKTRAKAAKDSPLKKEVAPIAEAMEEETKVVTLRTTEKTTLTSTETAPMLTNGNGIETSLTTPVKGEPTIKLQVDQESEEKGDVKVARNSEMIAKAKEVVAEAQRLDGGSDAAPVNGVGRKRKAEDIEDAEEAETDGEFDPRHVKRSKVLEEELKREKVKNKALIGLTAALAIGALFPYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHS3</accession>
    <name>A0A2T6ZHS3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_996486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000254">
        <property type="protein sequence ID" value="PUU75048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHS3"/>
    <dbReference type="OrthoDB" id="4037694at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="104" mass="11969" checksum="301D6EF277E0639A" modified="2018-07-18" version="1" fragment="single">LGGTILTGSIAYLTLRHLNKNTRAHSASLRSSRQIADSILLPKHIPKNPDPRLERPSFVETLKDAWNWEIEKIVRRVQRWDLRSAREEVEGTVGNVVEKVKEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHX1</accession>
    <name>A0A2T6ZHX1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1131932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000251">
        <property type="protein sequence ID" value="PUU75097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHX1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015735903" evidence="2">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="91" mass="9280" checksum="F4ABEDEB0D8834BC" modified="2018-07-18" version="1">MRQSNLLLLLALQTSIVAGAPSPAETTGDISSITTTTSLPPDVATVQISKELRKRKGGGSKGKSSSKGKKGTGSAASERVAWGGIEGKVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZID9</accession>
    <name>A0A2T6ZID9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1067582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000241">
        <property type="protein sequence ID" value="PUU75242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZID9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="715" mass="72116" checksum="B7299CB23EA1CE24" modified="2018-07-18" version="1">MEAVCAVLAASGILGYSADPPGEGEPDPHQSDGTGGNASGSMGGSESEHPHKADDGESGVSGSGGGGDAGDAGDAGDAESQPVPKVDKSKGSAGDCGGGSSGGGSGSGDESGSGGDIRNRGPLTHEEYIKWIENRDRAIAGLVSNAPAANAPVNPHVAPGFHTPVTGWGEGNGEPVSELGKDTGRTRGSDESDSGGGGDAGDVGDAESQSVPKVDKSKGSASDCGGGSGSGDESVSGGGIRERGPLTHEESIEWIENRDRVIAGLVSNAPAADAPVNPHVVPGFHTPVTGWGEWKGEPVSELGKDTGRTSGSNKSDSGGGWGSGWGSGSGSGGGGWGSGFSGRELFYDEDFVERFKMRAPLVGPVGDSFAVSHSMNTHGPFSPHSSVIDASDGKETIVPKSEVGRSSAGGSISGGDAGESSGGGDMAPPARKPETSMIKCDPRIPAGPLSEKEYTMWIKKREQIIASSAGNPLAGGSQTASGAKTLGKLRRRKVRSSGDDTPDPTSPGRRAGSAPHRPLASPSTASPLTGTGARSLPAPGTVLSCVVLGSIAPGCAAPGSSALAGSRDVASSVIFFGGVSPGGAASPGSAPGGAAPHGPAPTKPQTNDSPQGRRLKMLIYCYSAKWVLGITGFALTLVGSGLHPPDLAMESVQKNYRPMLNKMFHFGYLWVGSFLIALLARWIFSHAIERFHLMRRVRRLSEHDLELGNLAVMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIM4</accession>
    <name>A0A2T6ZIM4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1116465</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIM4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIM4"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="155"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="312"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="566" mass="62238" checksum="D441389B7803E014" modified="2018-07-18" version="1">MRSSLGPKDKLTVPSVIPTTFQSLQQANMSEMLETGKAPVSKPLPAPSAFLHTPESIPYSSSPSIIHLKRDLLVPLSFQSDNAEPETHDARAAAYNSKGVLNTRFGDFPHSSIVGIPYGSQVRAAPLTNNQQNRKRKRKQDTGEDVATEPTTSTGFLHVLAPTAELWTASLPHRTQVVYTPDSSFILHKLQVRPGSVLIEAGAGSGSFTHAGARAAYSGFEFHKERVQKLTDEIERHGLDGLVEIVHRDVCKDGFLVTRKVGKQEEEDTSPGATAVFLDLPAPWLALPHLTRRTRPTPSLPTSTGLTPSPSPGPGASVEKIGETTATATAVRICTFSPCIEQVTRTVSVLRKLGWVDIEMVEVQHRRIEVRRLNPKGYEDGAGPRTVGEAVQRLKWVGKYRDHKREKDSADSTIATVKQNPTEAWKTQNNREKKGAKAGKIVTRIEPEIKSHTSYLVFAVLPREWTAEDEAAAQTLVKQTTKGVVDAPVDGNLKGNGKPKWKGEREEKPMSKRQVKKAEREKRKAEEKRLEREEEMEDESAPPANEEERDDIPGAEGGNGKIEVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIP8</accession>
    <name>A0A2T6ZIP8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1116467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIP8"/>
    <dbReference type="OrthoDB" id="5385236at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="377" mass="41234" checksum="E3DFA190E37666AB" modified="2018-07-18" version="1">MPHVTRPSLQARSGLDNIGFGELWITVRTALLCPENRIGLAGPTLGGGLFEEWVTASLENWAGEMYWGAEARGIAKKKLVWGNGGEDEDCQEIRKVFRDLVIYIAGNARYTNKLRAISPAARGRGYSPAVNASGGGNDVIEGDGACVPAQLGKCAGLEFSIPYIPQPNEFPRFQRETAPPAAIQKNKHRYQTRQRSAPFRIKLSEVTPKPEPRRRRGNWTVHKKKVSRASEQADTPLNPTPLPLVPPSHSLPPTPLPPPWTSPASPPAPTLVKHSVAPSPERKPPKAYSSHQVFVTRLAEKTPTEPGSTLVKLVYVSDVQTLDSFLKKLCQKWGLPEVKGIRVEVGGQVFEVDLEEERDWEVVLGVVGDMAGVVVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIQ3</accession>
    <name>A0A2T6ZIQ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1131470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIQ3"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="319" mass="34540" checksum="7404C87E9E7A8EB6" modified="2018-07-18" version="1">MNAGYQVELADLLQWLRSAGIIIDGLAIGAGILSIEVINECIETALKHISFKRSFIDAIQQEINNCKGLPNFPGGSAEETYRCPAGGVIMVQSEMGEPIYKGAELDRAMFSLDRAKHLVDLNQRNSSHPGDEYLLLPSPALPIRLWFVKSRPPTPPGVTAAEEKLGIKKSLGVVFRNRGFFVGFGHVIMLPYGHTADDEAGVTDAILIIAGLLTELELLSQINDTTNGFLLAIRTLVLVIALISALLGATSFSLLSLVLEWAVGQTHPAPPELTNVTLWLSGQRLGAAFLITIDALKDKSVNEKIHGTNRRIEIDKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIR1</accession>
    <name>A0A2T6ZIR1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1067480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIR1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIR1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="45401" checksum="AEA74D080260B930" modified="2018-07-18" version="1">MTRITFTGQRSGPSFNDQSEIIWEKRLGDIAWAGDDLDISEQGDHIYSEMRVLASLPLHPYTAQAPTGYVALGKPGTARRVIGFITEYYKYGKLSEYIFSDSISLSSILGRKRRRKISLLQKAKWALQMTTVVIDLHRVAGISLGDSGGGFGLERFYVDQYLLLCLRGFGKGAEPKILSPWRFPPESQVRGEWEVRERYSRRNNAVESTLKGRQNHSARVKQEPLAQELEELDEKRFLKSIINTDNNEPPSLFNPQWKSIPNALEVVETYSLGVMLWMMLEQVPAELLDITGGVEVRWSEEMNIPDTWRNMVEMCVREHLEERVRLDEVRALCTQEVDRKRGATNGGWMDGWSVSDLNSPNPELCDHVLSLAFQRGELVGVLFILGYEPELALGNLYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIR5</accession>
    <name>A0A2T6ZIR5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1090469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIR5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="17385" checksum="1BD5FCBCD21BE2AE" modified="2018-07-18" version="1">MEEWGLCDECCCCCWMGWVRLMGVQYGTALVLHCTRTVWYPQERKKGEEDARLSPGLYLFESWSFCCMYVCMYVCILFRLSSSPGISVLCCKEGVGVYGRGLAFPVVCARAMDKWRVIVSMEDVEGKGTTSMRSLGHSRLLCGNRIVGNLSWAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJA4</accession>
    <name>A0A2T6ZJA4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1090080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJA4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015732035" evidence="2">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11900" checksum="A384EB1C8D2C93B4" modified="2018-07-18" version="1">MFLFLFFFSLQLPLIFTLLLGSRVELIGINGGELNSRNLSSCWSGLPEKIIKVKWTKRKRKKKAFLLVGDGLDWVLGVFALLFLRAHSVEQANEMIETIQWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJB5</accession>
    <name>A0A2T6ZJB5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1067310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000224">
        <property type="protein sequence ID" value="PUU75581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJB5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJB5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015631216" evidence="3">
        <location>
            <begin position="23"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="30402" checksum="EBF1E69D14AD878D" modified="2018-07-18" version="1">MKNLAQLYLLAALAVSPSLLAGMSPYPPFSRDLQPMRDPKFYAEIIPATKASGLGKRQTECRTGESLCPNAGWCCPSGNTCVGDTTNPGCQPPPRCGDGYFMCANMEYCCREGHECLPNHFCSEFCGLGGTQCGPDGCCEAGHVCDEKALLCNVTGTITLSIIPSTFQFPTLDTSFNPIISIPTISKTATSSTTPVSSSTTIPTTSKAATSSTTLVDPVTTTPTRPTSTNSDPEPTSSSTTKGENSSSGTESVNTGSSSSTIAPASGSNALKQAGWLGGFGILFFFVFFHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJR9</accession>
    <name>A0A2T6ZJR9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJR9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJR9"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="12251" checksum="93935018DEE1B77C" modified="2018-07-18" version="1">MSRHHPDLVMCRKQAGIAIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCVVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKNFRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK14</accession>
    <name>A0A2T6ZK14_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1053222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK14"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="22073" checksum="465803046A7E4DB8" modified="2018-07-18" version="1">MATFFSTIKRSFKDVAAEGEQIPTTEFLEAAESLVTLFDLLGSTAFAAVQKDMNGNIKKIRDRQTSHPKESDTLQNLCNNELAEGKRNASGGLLWLHRGLEFTEKALRKNIQNPSEELNISFTNAYGETLKQYHNMLVKGVFTLAMKACPYRADFYKKLGENEAEVNTQLEEWLTALELNNAILSRYLATVSQKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLA6</accession>
    <name>A0A2T6ZLA6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLA6"/>
    <dbReference type="OrthoDB" id="6594069at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="18867" checksum="47B14C4206F4B0F5" modified="2018-07-18" version="1">MFLYDTTVLLFASCIRNTVAKNLLEREKRLYKQRGPTSSLAKHGHIVKLVNVHDDQRLSLQEIANATKVLLSTCSDIIRFSILSISEANIPDPCSDENIHRRPTTIMGQNQALSAGEKVRVIVIALQDVLHYLIHPQIFFLLIVCTTATLSRFKKPFLTENGKAALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLA9</accession>
    <name>A0A2T6ZLA9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1194875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLA9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="124" mass="13318" checksum="A89FE0B36EDE2A3F" modified="2018-07-18" version="1">MLRLKGVKDDIAKVKTVQDRQGRSITDMRGHILAHTKELIRLDNNQLARMGNRNAVQGDGIIVALAGVGNAPIIGFPGTIEELDALDDPTIEALILALGIQVDVGAPMNLKKAIVRYYIGVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLB3</accession>
    <name>A0A2T6ZLB3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1194882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLB3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLB3"/>
    <dbReference type="OrthoDB" id="10594832at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1187" mass="130971" checksum="6A13B6A1D4C9B022" modified="2018-07-18" version="1">MERENEDVPGPPGNIAAEEEYPPYLAYFLLSSLTLGLWIFPWLPFISTLEWHIKLILIVLFSYLTLTTYASNRWISLFVAQAPVVLWWWANRVPIFKLALLKIFIDGLWHYFPQQVLEYGHIPLISFPLGLVLAHEYPDGFGEVYEELWRNLEGGVDVGELLRGSSLGWPRALLVLTAMGGFLVRRGRREDYIWGYLLFLVASFACPRPVAIICRLGAQGWARGLDAGVFVREKLVGAGWRIHVLRIIGLVWVVLVFVYLRRIRRRFRRMLPRPGTRRHDPPSDDDDDGYDSGWASGGGDHSGHDGDDGDDGDDGDDGDDGDDGDDGDDGDDGDDGDDGDDGGDGDDGDDGDDGDDGDDGDDGSGGDDGSGGDDGSGGDDGSDGDYGDYGSDGSDGDGGDGGGGGGGGGGGGGGGGGGGGDDWDDGGEDDDGGEDEEEEEEEGEEEVEEEKNKEKEKEEVAEEEEEVDEEEEVEEEAEEEVEEEAEEEVEEEEGGEERDEEEVEGEEVGEEEEPQEEEEEPEAEEEPEDEEPEDNAPVRALSPVKNLPIKYLPVKSPPVKYSPSKGPRSKFPAVKHPKGFPPVKSYPDPGPPVMQNTPPPFPVSASATSPSRGSPTRNPSMGPLIKGPPGKTPLIRGPPVKNSPIKTPRSMFPAVKYPLSKDSPPVRSRLGHDPRRKRKGHLPGSRPISRPPVEIPHAKIPPVDIPPAKIPRIKIKLNVKNPAPPPPNDPKIPRIKLRLPIKNPAPPPPNDPKIPRIRLRLPIKNPAPPPPNDPKIPRIRLRLPIKNPAPPPPNDPKIPRIKIKLNVKNPAPPPPKDPWAGWLWEWVVQVVNGTKVKLVKKKKKKKKRGGGRDNKGKKGPPGPPGGDGAGAGGKKGRTHGMTLRPPQVPKGGYRMQWPRSIDQFGRVLSRALITLATRTIFFLFPSKAQEYEVEMEGDRYVYEDEYESTWDEDDAEEWDGEFKTGEFGTDLDGEDIRGYDFFATARDDFAHLPRRNLRSSATTSPTHPPPTSTLKFFTSPKRRDFAYPPPSTPKSPLLVPPPSTTPHTPTITIHSPQDPNTFHELDASDIATSILSELPTLPILPTLRVSPIPPPRTNPKKPKPKRKPKPPGRRPGEQTTPLLEHPALKWITFWRILAIVAILFLFWNVGEREERFRAAEKEAEAQDWRHGFRRGVERVVYDEYEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLE1</accession>
    <name>A0A2T6ZLE1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1194856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLE1"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="918"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="988" mass="113524" checksum="083DB7B2E94C37E6" modified="2018-07-18" version="1">MENGDFGDDDFMNEEFGAEEFDEVYHDEGSDPDYTESDEDIDPALGALDDFTDDEGRSICSDVDDEDISLSALNDEMDTFHADLRAASGFKKPRRTGGRRQIGDEIYSFEIRGLLGQANSAYAFGKLDEAMKLVKQIIHIEPGVYSAWKILGEIFKEKGDKRKCLLAWLTAAHARPKDWELWVMCAKMSLDQYGTDNRAYKDQAVYCYNRAISAKPENIDAIYDRALLLKELGSLNKAAEGFVTLNRLLPNDMSVLKELAGLYIQMDKVPEAIEYYRRSVEHFKATGNPDNAFGWSELNIFVELYCLEKQWAKAIDTIGSVGRWLYGRATETYWDKINGDDREWDGDDRPRRCMVREFEAGRFQKESYYLPLELRVKLGLCRLQQENMEEAMHHFQHLHTEARNSPTYSDLFQEVGDALYGGGHFNEAISYYSVVVEGAVYLDRKLWFNMADCYKGLDNIEDAEDCYGTILEAYPKEDEAMMQLAGIYEVTGRKAEALDLVNQIIAMRREKEKAEKVMKAVTVTVQQAEEAESLAFFPNQPISERVKRKRTGILSEAEKMEMNAKRTEQTEIRYRKLEYLRPSMEAGDPEAVKEWLDTAGDLVDDFRNTRALYPHERKNRFKGFMTTAQRRALALGETRRIEKMQDRLKQSLTFEEEEIEEPEHLSRFRGLDFDTWLYIFMQYAICLAKYDNYQDSYDVCNAAKDANVFYHSKKRTFIIYVTWLACAIHVGDSDSCSTLSRWFMTTFQFTTEAYNLFTASITASKNGLEVFHNNANQKYLLRQIKAMDQVLTGERKTGAANLTGECPSGSASGEKYVPKEADVGLIMLYAHILASGKSYLSALNYYTRAYALVPGDALITFCIGLAYLHRSMQRQSENRHIMALQGISFIFDYYDIRCGRPEEQQEEVEKDVQPEKRQEAEYNVGRAFQHIGLTHLAIPYYERVLQISEENTIDGDLKWEAAYNLQMIYMTSGNAKLAADVTERYLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLM1</accession>
    <name>A0A2T6ZLM1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1088429</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLM1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLM1"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000736">
        <property type="term" value="P:double-strand break repair via single-strand annealing, removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006167">
        <property type="entry name" value="XPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00596">
        <property type="entry name" value="rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="11">
        <location>
            <begin position="714"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="487"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="936" mass="105545" checksum="0B687021F3309C2A" modified="2018-07-18" version="1">MSTPTSSQPKVSLPLAYQQDLFEEVCEQDQLVILARGLGLLPIITSLLHKYDAVGNNLVLLIGADDRENGWLGEALAEHAVRSGTTEARGLKIINTEVASVSARAEMYKQGGIFSVTSRILVTDMLTDLIDCPKISGLVVLHSERIIATSIEAFILRIYRQKNKEGFLKAFSDNPEPFTTGFAPLATMMRNLFLRSPSLWPRFHVTVAKSLETKKAEVVELEVAMTDSMREIQTAVLECIETSISELRKSNSSLELDDWTVDSALHKSFDVIVRRQLDPVWHRISWKTKQVANDLTVLRRILHCLLTYDCVTFYQYLETILATHAPPPGSTRSSQSPWLFLDAAHTIFTLAKRRVYIGKADLSKKASGKVPHGLEPVLEELPKWAMLAEVLDEIEKDRYFNPALSQSSGSTLIMCSDESTCRQIREFLQTMHETPLEDLINQDDELEEKPNRASAAYMMRRKLRAYFAWKPDFSKFSALLYTGEQKNQSQGQGNFGGPANKIPSNEGSRGRAPPPNKRRRVRGGAAAASGPNRQNTGAVQVTEEQSAQVAALLAGVQPTEGEQNLKQEIGADSFENMEDYYEFYEMNDLIVVHPYDGDMDERLLDELRPRYVIMYEPDPAFIRRMEVYRSSHKDREVRVYFLYYGKSVEEQRYLSAVRKEKDSFTKLVREKGSMSVTLTLDAKAVEDPQEAFLRTVNTRIAGGGRMMATAVPPRVIVDIREFRSSLPSLLHGRNVEVVPCTLTVGDYILSPDICVERKSIKDLISSFKDGRLYTQCENMLLYYKNPMVLIEFDQNKSFNLEPFADLTGNIGQHDLQAKLVLLTIAFPKVKLIWSSSPYQTAEIFEELKRNQKEPDPLEAVKLGLGPGEEIAGVYNQTPQEILRSIPGINPKNIKIIMSEVENLVELSNMEERDISALIGKEAGKQVHKFFNRSAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMJ5</accession>
    <name>A0A2T6ZMJ5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1028313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMJ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMJ5"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="13">
        <location>
            <begin position="10"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="12">
        <location>
            <begin position="184"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU76711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="444" mass="50082" checksum="E1EFAE2DF70320EC" modified="2018-07-18" version="1">MSEEPSQLQEYLIYFAQIHETFRKAELDSLSQLTGVGIEWKEYSDVSPFAIVHLPNNSSAKALIERSILAKGIYELWGTGPDYDHLHATIKSQTSHLWPSCMSRTFKFEIECYNGKRKQSAQREIIESFAYLGLDGEIRMKEPDMIFTVLEEFPEKVATPTRIFFGRRVGGGSRALVERYDLKKRHYIGTTSMDAELALVTANMALVAPGKVAFDPFVGTGSFVVSCAHFGGLCLGSDIDGRQIRGKSGRSVLSNFQQYGLVGNYLDGFVSDLTNTPIRQTPFIDAIVCDPPYGVREGLKVLGNRDPEKGKEPVIRDGVLRHLQDDYVPPKRPYGFLAMLDDIMQFAADHLVPGGRLCFWMPTVNEDFSQLDIPSHPQLQLVSVCVQEFNKWSRRLITYSRTQGCAQAPPMREREDRNGSKKATADELNSFRKKYFEGFRSSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMK7</accession>
    <name>A0A2T6ZMK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1087764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMK7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="18674" checksum="5692ACAC34CA4BF9" modified="2018-07-18" version="1" fragment="single">MVCSFVRYIRYSTDFFFSPPRCRHHRCFPPPHHPSSHRPGPGAEAKQKQKQVKQKDAGRDRVAATCIISPVQSKLQPSIFIPPTFYLPTYPPTLYVSPYLTIPYILPIILPVLILRYVVASTPDSFIAFIISSCHSKCCPPPPVYARASPLCQQLQNHTFFFLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMN4</accession>
    <name>A0A2T6ZMN4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1087685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMN4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="6998" checksum="1F04F64168BE28AD" modified="2018-07-18" version="1">MGTVVPIVAAVILKSVYKKVHRLPVLESLTTVSVLLVIAKTNSRVLALTVEGGVVGLAGLWVLVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMQ7</accession>
    <name>A0A2T6ZMQ7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_989226</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMQ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMQ7"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="79"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="79"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU76778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="356" mass="40324" checksum="7638316C67775DFC" modified="2018-07-18" version="1">MPNIMEREGDDLTEDEEPFLSPLQTSDLAPSSHVGDDGYLPDPRVDVEKMDSQNEKQRQHQQEESSRRQNSLVAGENQDDDAPYAVLIYRALMSTPSRRMVLSQIYDYFRERIPKFRRIKGRGWMNSIRHNLSMNGAFLKEDRPPEDPGKGYIWVLSKEAEIDGVKSTTRYRKSPPNAKKRATDEFYLRGSTVKRRRKSTRKGAASKSASSPCPSGSTGPMAEHTGSESQQDREQDSIDSPTLPQGFFKREETDTQPVRIHIFNDQDHPGLAALYSNEDRMLLAQATRIEAAQQVDFSNCYSSFPHNGTSQTLYNSEDEGLESLGEDCWQFCGNNDGNNDGNSDNFSEEFTLVTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMV1</accession>
    <name>A0A2T6ZMV1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMV1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMV1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="309" mass="34407" checksum="DC46CA0530313211" modified="2018-07-18" version="1">MPTVPDPTTTASPTPSSSSTAELSGPLDMDYYLTEGLEGVKRQRYGGGDSFKKAIQSRIDELLSVDSKAGQYVVFSSVQQSNIAYINHMRDTDYKGLRFLFLYNEKALIVKVMSQIVHGLAQGQLMDILRVEIATMGLRNALVNVGGVRFEGRQSSKEADCAMKPGLFRRHPTDWPTLVFECGVAESWRRLRADACWWFENSHQEVKIVLVLKVSKADRKIKLEQWEMATGPNPQVTQGHPDPTKTSLTRTQKITITAPLGSGAVATAPFTLNFKKVFLRDPVPAKGEKDIVFSKEDLQALATHVWDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN43</accession>
    <name>A0A2T6ZN43_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1128971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TBCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN43"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN43"/>
    <dbReference type="OrthoDB" id="296187at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12585" checksum="3DC6EBB3D6492848" modified="2018-07-18" version="1">MPPPTPLSIKTSSVLRLIKEEASYHEETIQQKAAVEKLELEGADEYDLRQPRQVLEQTIVMAPAVRKQLHTALGALSEAMEAAPESESEENKEKAKRALDDGRKVLEEHGVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNP8</accession>
    <name>A0A2T6ZNP8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_197189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNP8"/>
    <dbReference type="OrthoDB" id="5300368at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="538" mass="61349" checksum="B69C221F6BC34980" modified="2018-07-18" version="1">MRRTKRAIIRKSKVRPLGPPLPFLPAEILLQIFEYLAPNNTLPQSPVHACHGVSLERSSPPNDYTCTTCQTSYLLSVSLVSRHWHKTARPLLYRVVRIGYSMFIPGDEDIYFNCINKAYHGKDRFFFNVFDRERPESRKIGGCYAGLIKMHEKTKLETLDARLKTLRLFHRTMARSPDIRRMVVCWELGALFPMPTPGWRGQAAWLKKDLAYRYPLTEALENIGRLVEETIPYLISLRWIDFHLDPEVVGASAEALGYIVKKSISRMTWKPQLEGCKCNHVRIQLPIDRTEYGHIPSLEIYSDFDLPRYSPAIFKALAIETCEIEINRPTRPSFGRESPSSGGIDFPMTTAMRLIGAGAPTISQVATGGILTAITVGDKDIRFADLRNLLAHSESLKHLRLENVHVSAPTREDIDNSSEAIVLKSATLKSVFWDIVLKDTEDVRAETVTYYLIKSTSEDCLPVLETLSGPAEKFYTEWWLSELKRIHPQKDIQMRSLENEVVVVLRPSTKAADEQFVLTKRTSRSQTNNQLFRDAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNV1</accession>
    <name>A0A2T6ZNV1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_987783</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000161">
        <property type="protein sequence ID" value="PUU77153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNV1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNV1"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="276"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU77153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="549" mass="59977" checksum="D5E1B713DAD76643" modified="2018-07-18" version="1">MAAAEFYNTGPRPAGNSGLNDDDDYDRHNTHSPISSISNSASPVHKPLPPQPPFPPTHAATGYTDDFFGRHHSTQSIDTAYHPHTFDQPPGPSHLGSYSPQGPYGKSTEPYNDNIPLNDTRPGQNSSQNLAAIEGGGHVGSKGKKGKGKFPFLKSSKGRRRPWFCYLMSVIQISVFIAELARNAVLTKTPIAIKPQFNPMIGPSVHVLINMGARFVPCMKTIEGITDNPTITYPCPNTTVSDTSKEGCTLGEWCGFGGGNIPSNLGGTAPKGGEPNQWYRFITPIFLHAGIIHIAFNMLFQLRLGVDMEREIGHIRFAVVYFAAGIFGFVFGGNYAPNGQPSTGCSGSLFGVFALILLDLIWTWRLRKSPGKELGFLMFEIVLCFVIGLFPGLDNFSHIGGFLMGLFLGLTVLHSPPSMRQKIGAGEPPYTPMAANSPPYAANPHSALPSGFGTFFKNPAGFFKGRKPLWWAWWFVRAATLAIALIVMIVLINNFYKYKKTCSWCKYLSCLPISNWCEMGVLTTTNTTSNNPARMLARSVALTDLLQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNW9</accession>
    <name>A0A2T6ZNW9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide repeat protein 36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_987704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNW9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNW9"/>
    <dbReference type="OrthoDB" id="539634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038906">
        <property type="entry name" value="TTC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405">
        <property type="entry name" value="CDNA SEQUENCE BC021608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21405:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22122" checksum="0435B4C7F268BB11" modified="2018-07-18" version="1">MSTLTINDSTVLTQLFDPESAPTSASPSIDSSLPSDPHTPPDLLQTLKRTELKAIKLAESSHTSLPESRKLLEELTTAHPTYASAHNNLAQVLRMLSAPANEVLPHLNEAIRLSSPSTPTSPLSPLQAKILSQAYTQRAAIHYSMFKQGGNEDMEVAASRDFFEGGRYGNAIAREMAVRTNPYARLCGAIVREAMKKEYGECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP43</accession>
    <name>A0A2T6ZP43_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP43"/>
    <dbReference type="OrthoDB" id="4638065at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="498" mass="55948" checksum="4CCF66B6FD165BEC" modified="2018-07-18" version="1">MLHLSQLPRHSTKEGTPGKLMRPPYHETPTGIKQMPGRKEPVTIDTTLYPTVKSRVEGGFASMKLSQPKGKRPRLRPRTDSEMEDWFDKGMTLTPEDKARQLARRQKRGVRGCSVSFNASKYTVPLDYYGSATGNHKGTVYLDVPRLCIAHGNIIEVFLNIDVETHNSRPHLAGLQALSLDQCDALGASYQQIEIGAGELYVALDRNYRRLLVVFANPFSAIYGEEVGKRIVKQATDNITKYCEIQPPGLPGNIRHNHTEEWLMRNPQHYAYPNSRCGVFHWGIWAQQGHESLGPVLTKDTNGVGSNTRGDLQGLLASFQNISQLTRLLLGAIDRSQRNTMQSAIQLLPGHFRNLWTNYDNECFSLRACLINVVTEPHLDHGDLDWTMSTPLGKFEGAGFCVFELERCLHFPAGSTAGIRGSKLIHFTRLWTGSRLCLVSTMHRSLLRHVFGNSERPNQTETGTGRRHTRKRKHSSVNGVSLPDLRNEGSDSESFLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPL1</accession>
    <name>A0A2T6ZPL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPL1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="65" mass="7843" checksum="9518850D226B7F46" modified="2018-07-18" version="1">MLVRWISPYANSTFFALNFWCLIMYRLYRIVQFTKMRQLDHLVTHLIGCFFSSFCPTLLLYAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQH4</accession>
    <name>A0A2T6ZQH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1128001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000145">
        <property type="protein sequence ID" value="PUU77684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQH4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015581790" evidence="6">
        <location>
            <begin position="21"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="570" mass="64613" checksum="D32ED33374B0762B" modified="2018-07-18" version="1">MLAPIFLTTALLFMGHTCYSLHTQLCKVRSLGIPYFVIPFCPSPILRVFLIPFVNLLIKVFGLTHPQFFLMTLDWQVRQRYEIYRLIGSDMFFTVSPWKVVLHVADPDMAVEVLAGKGGNGELYTRPDVYNTMLGLFGENVLTVEGAVWRDHRKITAPVIGKSLSVVWEESLTQIEQMIQYYDKLEAINTSYRDFRRVTLGVIARAGFSKVMEWCPLTTAIANEKDGEGSYQKCLHVLFENLIWAVIAPSWILEMLPFKALREAGGAANNFRFFMNEWFEERKTKIELDNKTTLGPSSKADLMESLVRSSGLDKDSTLEAPLLSKSEVIGNAFIFILAGHETSAHTIANAIYLLAMHPEYQVKLQEEIDSILGDSDHNQTSYEAHFDAFSSGWMAAILFEALRLIPELTVMARQIGPTPRTFSRAGDLRPITLPPGIEFWIHVIGLSHNPKYWTQPGKTEAESAISEFRPERWLPKPGDNIMFKPYNGSYIPFSIGARGCIGKKFAHVEFTAIMLGLFRDMSVEFDSCGGKKTFEEARLECSVQMENFESKITLQPTGEMPGIKWVRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR28</accession>
    <name>A0A2T6ZR28_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1085191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR28"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR28"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Syntaxin N-terminal" evidence="8">
        <location>
            <begin position="28"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="310" mass="34673" checksum="B697DD24E056B525" modified="2018-07-18" version="1">MSYQGYEMESPLLQNPEPHSQAGGHGGHQALPLNTFLNEVTSVRSLLTTFRQAVLDIGALHNQTLQSYDNGATSGSTQQLESLVAETSVLTKQLRDSIKSLERDTLIMDDYSRQNTKRQQVDKLKSDFDKDLRTYQQTENSFKTRYRDQMARQYRIVNPEATEADVERMVESGETQVFSQALLSSGRSREANSVNAAVRARQAEIQRIETTLIELLGLFEQMAEQVVLDEPKIMHIEENTTKVERDMEQATTYLGKGVESARGARKKKWICLGIGVGIVVVIAVIITVVVVVRNSGNNKNNNQNPKPTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR59</accession>
    <name>A0A2T6ZR59_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1144098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000134">
        <property type="protein sequence ID" value="PUU77953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR59"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR59"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31091" checksum="8658B4B3DA28850D" modified="2018-07-18" version="1">MQRNRWTTWSVIGTTQFSSIFELNRKITTPLTEPPPNPQESRENTAEIMFETFNCAGLYIALQAAVALVASWTSSKVQDRSSTGTVVGSGDGVTNVIPVAEGYIIGSSIQSIPIAGRDITEWVQSLLRDRTEPDCDLKTAEQIKEKFCYVCPGIVKEFTRFDRETARFQKYVVAQPKGQKVTVDVGYERFLAPEMLFNLGIHSSDFLMPLPTTVDTAIQSYPTDVQRGLYKNIVLSGGSTLCQDFGQHLQRDIRHLADARIRRKFVGSNTGIQKLLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRC6</accession>
    <name>A0A2T6ZRC6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_984775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRC6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRC6"/>
    <dbReference type="OrthoDB" id="4507199at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="586" mass="65378" checksum="DF85562C95E8D37D" modified="2018-07-18" version="1">MDVGVPSVRNLFRIKGERTLLWIVIGLTSIPLHLLYNAAVYTSVAGNDFVVTVVTNNHFEPGAYSNMTEALNGYFEMPFNALAVGRYGYPNFPLFSGVLEGYNVNTSSYEDLTASECTKLYNTDYVSSHRNLFLITNHSSNTTHSNTILDMIHVGNLGISPSSWMCAYYQAGEARVYLEPAFPCNPSELTSNVMKGIPWQVNLTTGEEVGISGCKSEKTGEKCRVRFMLNIMIVVICCNFVKACCMVMTVVRSREPTLVTLGDAVDSFLRAPDRTTMGICFADRRYIKREWTRGGWRAVPKQWKQKGVQRWWTSVSKVRWITCTFFSSIIAIAAGVSLRWGMDYEGQYWSTDIKSMWARGFGKANSVALVNLWFRTTTQSILTANSPQTILAFLYLTYNSLFTCMLQGHEWSLFSHQHRPLRVTSPRLGQRFTYWLQLPYTYAIPLMTLSGLLHWLTSQSLFLAMIEVSDPLGKDDPVVMAGVGFSCIAIIFVLTLGLLALLTVTGMGYKQFAAETTTVGSCSAAISAACHVWGVDPEEIVGKKLRWGDVGIAPTLGVRHLTFSSEEVVRKPVFGEVYAGTGNDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSA6</accession>
    <name>A0A2T6ZSA6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1126938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000122">
        <property type="protein sequence ID" value="PUU78346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSA6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSA6"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015738288" description="Secreted peptide" evidence="2">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8027" checksum="FE50AA085400DACC" modified="2018-07-18" version="1">MLLLFLFIASLSYWVATPSPSPMVTINILPFIFVVFGLFNSIIVPRSDIPDIFYYTCTTSSPAHNTSVASSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT39</accession>
    <name>A0A2T6ZT39_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000111">
        <property type="protein sequence ID" value="PUU78647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT39"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="58" mass="6405" checksum="7D2A93DF0A99BCDC" modified="2018-07-18" version="1">MTDPQVNYWMGSDANVVNYVLKGGEQLNIALLVPDDIPKCGATTMEGDVGQMREIYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTA3</accession>
    <name>A0A2T6ZTA3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000111">
        <property type="protein sequence ID" value="PUU78654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTA3"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="499" mass="56851" checksum="096D07F205A45E97" modified="2018-07-18" version="1">MDDDEMEMEEEMEDESDSTISDKEHEEGEGMDVETMVEAERASEDDDSDDDNDDSDDIDDEAPEPGYEDRDVGFIDDDGEEDDQGDDIHEEEAMMQEDYQDDEGTLSAVPCGWANETGEGPMMARAHPHGHSGWYPLGPHESPCQTEHAIIATWAAKLREQPTLSINTHFDSRIRTMNRPPPSQPTIVAKNSWEIGLPFLPHLAHHYYYHRAHFITRELRSIFEAARLEPDMQRHHQEDPQTRVNSFIPTFTTSRWTKESRLVFDSSTPERVLRVVNPILVLLVPPAIEKERIRQEKQEKGWLKIIQVEEEPTKKEEEERITREMAGEEDRIRKEAEEQEATERGAAETAEAMEGASESDAPDGENGRQALWILQQHELLSRGVQYWQFNQFMDMSRVARANDALHPGEPELIQIKPLRKSVIQLDKAGGATLLPLMFITQVGSTRLTVHEILLNICKKRKNFAEVVNLLLSILQDSSSEMAAVERGFAQLSVRESLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTB9</accession>
    <name>A0A2T6ZTB9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1114817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTB9"/>
    <dbReference type="OrthoDB" id="5278907at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="14690" checksum="28A9ABD2D17F402C" modified="2018-07-18" version="1">MFPTRALLVQKVYKAKKPWPPDFSLLSQKHQFRLERRYRRRMKLKFARPRLQKVVKLAQGVIISTLAIWAVFINDWGERGNRPVQPLRDWVSDLKKSFWSTPSRPKLSGQPRTPSSSGSISEASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTY1</accession>
    <name>A0A2T6ZTY1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000103">
        <property type="protein sequence ID" value="PUU78941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTY1"/>
    <dbReference type="OrthoDB" id="5405400at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="9765" checksum="B825DD0511576B68" modified="2018-07-18" version="1">MSGETTSRVYHEGHFGKKYAPAKNESAPLENVVDRFGNRKLEMKFGMACDRGVSTAWLSRWGLDSGFRAVDMAFPGLEVKKLELEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUG2</accession>
    <name>A0A2T6ZUG2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_980516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUG2"/>
    <dbReference type="OrthoDB" id="5380478at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="404" mass="42833" checksum="32A10F6CC287BA09" modified="2018-07-18" version="1">MSPTKSRPTIARRTVSANPSSSASSIPRRVKQTTGATKLRKPTADFASKTSPKKVSSLLQDESVNVSPPKPLSYTSGANKENVPVTISQGRITYVGISPSRQPTGVSKLPKSSLAALKKKAKGRIPLRELSEQEVFERDEAVLGDLRRRRSGEHGAFEIDSVLANPQASVNRNSRASSVSSSTHGSTSSQSTAATEVDGEDDDNNISNGKIRVLKKSDSEEELRAKINAILENTASAKPSANNKLAKRKGLLTKATRLSPMKASHPAVRQSPSPKKAYHSEAASSSPSVAYSCGSPFSSPLKASTLPESPLRILHSPSPIVKPAPVRTGLGNKAINTILQDKSAADKGKKVIITSSNANQPLKKKAIAKKAGSSSLRRAAGSVRSASTTSSVNSSRLDEMRKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUJ3</accession>
    <name>A0A2T6ZUJ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_852077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUJ3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015419705" evidence="1">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="20292" checksum="D2CF36BAFB2F8385" modified="2018-07-18" version="1">MMGAWSGLFCSAFFHSSFLDPLNSLQTAAQSRPGVEENGREGKGRKERGEISLPFLPLRFIILSVSFHFPPPTGSRGRDPPSKRKKKEKKRKFNCGSELYRAVFVQDDISSCDTRQACLIDLRMMILVCDYDNYFFLCFSFPSFLPSLRDVPGLVCLAYPSATRLEYRNSTPSIKATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV02</accession>
    <name>A0A2T6ZV02_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1047115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV02"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV02"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="368"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="467" mass="48437" checksum="F62DC4A962EA32D6" modified="2018-07-18" version="1">MSANVNTDRPEDPEEATIINPDEAEEVVEDADSDVPMDSDSDGDEPMEVSLVNDAKAYFDKHGESIFSIAAHPTNKSIFLTGGGDDAAYVWTPDQVPTDPEEAKIIPREGKAIARLTGHKDSVSAAAFLGKTGQFAVTGGLDGKLQVYDAAQNWRVVDEAQEVQEVNWISAHPSEVAFALGANDGSVWVYSVDTGAGKLTFKQVFTSHTASCTAGVWTSDGKLLVTVSEDGSFYAWDVDAGRSVVALTAADQRFAIEGGLYSVAVSPSGSVAVVGGATGEMRVVGMPTSQAAAGARRTAGRPQAGGGGSTGGGQAGQILAALHTHTESVESLSFHPTQPLLASGGVDGKIVIYDAGRGYPVRKTLGEEGGHHEAVVKVEFVKADGWFLTSCGVDGTVRRWDVRAGTELSCWRGHLGGNAAEGEGGVLGFVQTPERIVTAGDDGVALVFEVVSSGGTVAPTITGADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV62</accession>
    <name>A0A2T6ZV62_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1107750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV62"/>
    <dbReference type="OrthoDB" id="5409345at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="209" mass="23677" checksum="66B3F49957B3808A" modified="2018-07-18" version="1">MTDASTTPTTPHLLQKLNSLTDTLTTLLSESRKNTLAQRRTHKLLLRLESLSIENAWIRHTFPTTPVLTDEFFGGDVEGDADALREEAEPEFERRYGITRECLGGIVHRDVLRVISRRGSLVVVCGGVLSREWEDTYRGFLEGWLERGDGEGALTEEEVNVVNRLLEYVPKEGGGEQDAFNAVDAGRAINGQWEDRRFIRDYFLHDICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVE0</accession>
    <name>A0A2T6ZVE0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1100809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVE0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVE0"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="327" mass="37294" checksum="F03A7163E2BC3E35" modified="2018-07-18" version="1">MDTKMEDVGKTPPPPSIAVADPSSINQLDGWIENLMQCKQLNEMDVQRLCEKAREILQDESNVQPVRCPVTVCGDIHGQFHDLMELFRIGGPNPDTNYLFMGDYVDRGYYSVETVTLLVALKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKLFTDLFDFLPLTALIDNQIFCLHGGLSPSIDTLDNIRALDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLVARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDENLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW51</accession>
    <name>A0A2T6ZW51_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1081205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW51"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF6">
        <property type="entry name" value="LETM1 RBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="154"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU79664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="369" mass="41178" checksum="3ADCF664E40C88AB" modified="2018-07-18" version="1">MISYTAKYLPSTMSIATRPQLRSTYRSLVLLSRVQPSSTSAAAAPAKAHDGGGTGGGEHKVPDPEFVNAPLSTLPAALELPHKGPGDSTFPHLIKTGKAYLGFYKTGLKNVYKNFIATRPIQSRIDKKGSITDLVEAGEITRREFQLVMRNRHDSRRIPIFGLVFMVFGEFSPFVLPFISGVVPINCRIPRQIQGDRIKLEERRAASFQNLPKGRNLSELAQEKGSVRNLTSNEVLHCSTVLGLHSGKWPSALYPFLPPTMWLRFKLWRRLVYLDLDDILLARGGGPVMLDSGEELKMAAVDRGFNTLQKTETRLREELKLWLKAKETAGGKTLALWLTRPTEWRNSFSSSPPTTPPPTLQHPTPRKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWG2</accession>
    <name>A0A2T6ZWG2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_797987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWG2"/>
    <dbReference type="OrthoDB" id="5392262at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1150"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1211"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="801"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="887"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="847"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1238" mass="136615" checksum="0747EDA39697AE73" modified="2018-07-18" version="1">MQPNGNANASQDDTLREFGTQPQHTTTVAYQTPTPPFGYSSSKPYDHQYTISDSNQIRSEFVSPGDNSYEIPGIPHTSSAVQRHGNASPVSATSAMSISSGRSPRSVFSNNKSGTGPRKGPICIKCQKPECAPIDLIVSCSRCLENYHTSCHNPTISVTRGVINVDSSIWKCQRCCATRLTNPGKRSRRQSVSPTRSRPRKIPRLSANASDASSGRSTSLSKGSTRMTFSPAELQEDGTTRNRNNHSRDSKHQPSMGGVLDPHGAGMSESLRNDEITSQWNSLVAAATPGDREGNFAHRTGDGIGSTRPIGAGGQRTLQYNSRDCPSEFSAGVERRFDVPELTYYSDGMSRSANVFSGSRKLAVVIDNRSRSGSASTNGYQGEGWNHTPPAAKDPRDDVVPIPHSKLRQTLNSPNPQEFSQPSADQSPFLEGANGSTLRRRLKRPRFTPEVPDSQEHERDLIGQQARGRVAEDLRHARLQGRPNRNYPFDTRNNEEPPRSRPSSSSHKGKETVERLTTERTGVPSPHYSPPPPDAGANGSLSHRHNETDHLASGLPVVQTRSSSVDTVVSCRRCGSDIATFNSKRADICSSCARREHCRGSDLTDATSREPSHSTAPSHHSPAPSCLRLRIDRKNDPRSRHSSSLSAAGLPDNRSNTTPNSDSLPSDISRGCTPQELPPVGVFLTAKQRVIEKYQMKFPEITTGGLPSQPIKETAIRGQKARKVIDPPKPKVTTTAERLKTTVPLKKNRINAATLVQAATRVDARKSINGSTLPDILSATEPPKHNARMTVMSISQLKKPARKGPAIKHARGSISRVLVTDDSSSESDHGGKLRALEKRLQDQKGYTKNQAEKAAKLQVKLQESEKEKAALQEKLKAFLALGNHAANERPALGNDNPQPEAIAKPLPTQRSSQQEPPKKKALKRLVRWEEAHSDLSTPQEDPQTEPGAEDDKPDTGKKTFRYGSMRDFYSGSKFCGEDPWAYPTTLEQPEPDPSTFRKRGWRKTVYRPFDQGRLMKVHLHRLTSHNRPPLTMTIEENPLDDDDEFASTPNTPINTRVDKPENERGPIGVPRAISFDEFMGLPENMVPTVKDGCLGFRSGIIVSLTIFLSYKTLSGKPLLIVYRILALEDLRGMHRTTGFELQGILNLPNVYFEHILIPFSISLLSFVFFRDPTASHPLIPLHLLLLYNNLRARKSKGGSYTTYTRVHLPSCFFYLLFFSSIFCLLYTQSSVFTFICIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWM0</accession>
    <name>A0A2T6ZWM0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1107385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWM0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWM0"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039553">
        <property type="entry name" value="Prefoldin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13758">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="3">
        <location>
            <begin position="530"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="611" mass="67795" checksum="B08BFD9E22103C8A" modified="2018-07-18" version="1">MPIEIERSLELHRQRLEASLEKLRKALRHWQVSSAEYEALREELQTLPGNSTREDMMKLKVGSEFGGTVVDEKDVKALLGDNVGIKRTVDQAITAVGHRINYVQENVDKVQKQIDQGEAKLASLLVVSEPDLETEDGLPIMDIREELDEDGNIINTTINGADPSLGKVLDTAPIEQLQKLVEKDKDAKEQKPPVEPSEGTSENKPAEVFKPSPQMPSPSIRKNDKTPAENELDGVKPISSKDGEGGGFVRVLDDPVLKEEDFVKEVPTDSPEEAEMRKQMLNYNLQEIGAVVAEINLEEEGIYYGHEDDLNEETDELDSEDEDRYGRTATRVITPEYQKEMEDLARKIKERGEAARAAEAKMREEDSQQRKDEAKAQKPKPKKKGVRFAPEPEISPAPPLMPDLPVPPSAHNTEDALPLLVDLLAMDAMRRSGVAPGSTAPAKEKGPSIFKSEKAKVQNEKVAEVYERVVPVSVLSSNVMERSADDGSASFEPPISRSRNVSRFKAAMAAPRDDDADHDDVSPPKTSTNSSVIEREVSESIPVQPPDELDPSTHRAEVAVEYHRLRNKMIQQQGGFVESEEEMAKVPLDDDGETRKVSRFKAARMKGLAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX15</accession>
    <name>A0A2T6ZX15_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Clasp N terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1124105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZX15"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="290"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="583"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="952"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="987"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1016"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1352" mass="148817" checksum="0A73D11B78A41689" modified="2018-07-18" version="1">MSVEANVPEHLLVVLRGHDVDQKIAEFSSVKAQVKHHFVQVEAINLLFEACRIGISSSNNTLSLHALSCLGHLIKRVTLQDQARIKPQVHHILPLLIEKLGDQKDRNRSIALTALLDLWKTTPNEVERGIKEMGFSSKNPKARQESLNWLLQVHSAGQGFSFRSFTPFMIKALEDASEPVREASKEVVVELFKNAPDHAKSDLKRELKKREVRKGIATYIVNQLGLPGAGDVAGGSVRSLDGHEEDGVSRQGHSMAGSINGSMASSTYVASLAGSELDTMEPAYVNTNRELEEILHGMVEFFDGRESEGNWAARDRNVTKLRQLVRGNAYRDYQTTFLAGIKSLLDGILKVVNSLRTTVATNGCQLVKDLAKIIGPGLDPMVEILLSSFIKLCAGTKKITSQLGQVTTAVLIANVSYHSKILHHMWAACNDKNVQPRSYASGWLKALLEAHVDQKAYIEHSGGTDLIEKCLKKGMSDANPGVREGMRQTYWLFASIWSERAEVMMEGLDNNTKKLLAKDNPNAPVTTQLKGVNSLRAPLNRGATAGVPGRPSVKEAILASKRSRGNLRAQPERAETMPTLPMVAASPAPTTSGLASAPVRPRRDPTKGGNRVDKQTHDAAAFARAVSPTGTYPSTRTSPLGARGNGVRSPAMNSPPRIHERLARGMTPARQQSPAPVRKLTVLEQLNHADWKVRVEGVIIVACILAKRTPPNYDGQKMPTLPPSDVFAPTLAKLLNDPQPEVVEHVVAPEVLAELIKVVPMDQIVPKVLLLSEGDDAEHSQPITSYSIPALKQLMAESEAIELLFRILTSMGVSGVVPRKLALGSFTTTQKRKIIHGCLIWMNEIVESHLNGSPNEFLSDVSNFKLYVNRLIAMLNNTRVPNYNPLTGLLKNLQRMDLEAFDKILNTFESQTVRDLKKAWGVNVEEDGDLIIVEEKVADVEQVLGSVPRIGMRSPPRNFSPTLKKGNYFPESPQNLKDEDITMISLPPLPPAPRPVTPTRANAEDNATDLPPLPSTPESSSKSLASQNGTGRRSSRADDKNPIIKVYQDPVIESNGAVATSTGVDKGPAAGTGEWYRSKMKKQISNSNLPKTPEHSSRLLLTLITRLQNREIDTQAFRKLIGIARENPVRAVLQENNSETFHDIWEGGKVFNELLQALLEYLEDDSIDAERAADLRVQGLLVLKQLLSKTAPYFSRHEAPVLHTLIDLRGKYPTQSHVTTGIEEIVEEFMAIVDPTTGIEAILSVSLPQDKPGFRQATQSWCMSLTCLAALVRGSKIASLEPQFARLGQLAVKSLDDEDAEVRRACVSMCIEMHSKLRNDERLFDQILKGMKSGHQNLLTYYFAKREGEARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX25</accession>
    <name>A0A2T6ZX25_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1022076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX25"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX25"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="39573" checksum="7C5959D741E1730C" modified="2018-07-18" version="1">MTSTKRQHLGNVLIVGGCGFLGQHIVTLLKEHHPECEIFVMDLRLSNTLPGVTYLEGDVTSRESVDSVLNKVKPEVVIDTVSPVHGLGEAIYYKVNVDGTKVLLEASSDAGVKVFVFTSSASVVFDGASDLISVNESAPIASPAMDPYTETKAIGEKMVLEANRKGGMFTVALRLSGLFGPGDRQLIPGMLGVLARSQTKFQIGNNENLFDFTYIVNAAWAHILATEKLIALSPNTPKTPETPDGEAYFITNGEPCYFWDFPRTIWAIRGHVAPFHIVMPAAVGVAMGGAAELFAWLLNREPGLSRFRVRFSCWNRYFDIRKARQMLGYQPLVKLYDGLVETLKWFDEQERVEAAKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX26</accession>
    <name>A0A2T6ZX26_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX26"/>
    <dbReference type="OrthoDB" id="5457085at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="323" mass="36041" checksum="20EFEAF891156E08" modified="2018-07-18" version="1">MGPQDTSLQWPDFLRFRVLEDTTPFHNWKMLYQAQRNGKRSIMRDCYVTAGWDNRSKLPLWLPRSSQDPGTLQALIDAWFPTIKDKLTIIFEYIDTDIKSSALLGIFFITPSVKSIPAQSLEGRQGSKYSIEINTENFEADTIRSLSESSLISVTELISQGRKCQQLISDPDQCPTMRDEPVSPSDHISETSLSSIPSTPSLPQPQLISLTSSPPQRTQLLAVSRLQRSPSPQSQDPAQGSSPDSLPNLPLVANENKTITLVNIQGPRQSKNHAQVASSSPIQILSPLQIPVVDRVLRLHKGCQQPSKRVYSQSRKLSDIDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXD3</accession>
    <name>A0A2T6ZXD3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-grasp domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1063682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXD3"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="3">
        <location>
            <begin position="136"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="443" mass="50851" checksum="000BF22DA3527E64" modified="2018-07-18" version="1">MCCFKPKKKSTASLNVLLSNGRFPVSIDLARQLKLAGHNVYVVDPMHYHVCKFSNSVKKSYQVPAPHIDAVGYTEGVRRAVEDANIDLIIPMHEELFHLAEQTSDVNGRDNQILRKRLFAPNFQTLIRLHNKLEFCQFLRKAGCEAPRSWLCRSMDDIRVLPHGEMELALKPVYGRAAMNVYHLKPNTPLPDKVDVDPENEYIAQEWITGNRYCSYSVLWDGRIFAFSVYPVVDTIDEASCVYFQSIEHASIRAYVERIADALPGVNGQIAFDFIETDNRLVAIECNPRATSGIHLWSGTPDLAYSFTRSSPAVAKPGARRQLLPGMLMWSKKSAGLGEYLRHMKRLMGTRDVMFSRRDLLPSLMQPFLLTSYYEICREREMKLPAMFQWDLMWEPGREQLENVRRLLAREGREETDGERADVERKERKSLEKDSSVGMERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXN3</accession>
    <name>A0A2T6ZXN3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_975524</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXN3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXN3"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="13">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="436"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="682"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="989"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU80267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1057" mass="117249" checksum="F14B891780EBBC62" modified="2018-07-18" version="1">MSPSDTAVASENQKSVKVLEELLQKLSVSKTKADATYAAENLATFINGPIEEHEVPTKILDLIKKQLANKKDPLAREHALTAITAICSKQASASIEPYIVSLLPKVLAAVGDKITAVKVAADAASLKIVSTINPNAVKAILPAISYSITKAQKWPEKMTALKCLDVLVETAPGQTALRLPELIPTVSEAMWDTKPEIKKAARAGMEKLCSLISNNDINRFIPELINCIAKPEKVPDTVHLLGATVFVENVQAPTLSIMVPLLERGLADRDTTIKRKAAVIVDNMCKLVEDPQIVAPFLPKLMPNLQKNYDNIADPEAREKTKQGLDTLTRVGDVKDGKIPEISTAGDPKVILEIVKTVLSSKKDLVAKFEPILAYIACIAGSLVDEKENEVLIWTEHTVPYFAAFLPEGEAQSTAETLRKRAAPGAAEEEVDEDDEEGEDLCNCTFNLAYGAKILLNQTHLRLKRGQRYGLCGPNGSGKSTLMRAINNEQVEGFPKKTEVKTVFVEHDLDSADTEKTVVGWTFDKLAETGAGVSVEDLKTKLGEFGFKETMFDAPITSLSGGWKMKLALARAVFENPDILLLDEPTNHMDRQNVKWLEEYLINSPCTSIIVSHDSGFLDNVVQHVIHYEKFKLRRYRGNLKAFTEKVPSARSYYELGASEINFKFPEPGYLEGVKTKAKAIVRVSNMCFQYPGTSKPQIRDITFQCSLGSRIAVIGPNGAGKSTLVNVLTGELIPTSGDIYTHENIRIAYIKQHAFAHIDNHLEKTPSEYIQWRFQTGEDRETMDRANTKLTDDDEQAMNKIFRIEGTQRRVISISSRRKFKNSYEYECSFTLGENVGQKGEKWIVMSTSDNAWIPRTELIASHAKMVAEVDRAESIKAGQFRQLIRKEIEAHCAQFGLDAELVSHSHMKGLSGGQRVKVCLAASTWQRPHLIVLDEPTNYLDRDSLGALSRALKEFQGGVIIITHSEEFTKDLTEEVWSVLDGKMTPSGHNWVQGQGAGPRLEEKGGEEDVFDAMGNKVESGKKKKKLTSSELRKKKKDRMARRKRGEEVFSDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXX6</accession>
    <name>A0A2T6ZXX6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXX6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="134" mass="14895" checksum="3E4398E2DB8B2EC3" modified="2018-07-18" version="1">MDASSKTYKTRQKIVNQHQLPTRLYGAPEEAKHSLSSVYQPTPQESITASPSLSGRNPPCPILTSDFIPRRISKTRPCSPVFPPSLPQPITASAQDKRYSPEGVGVLKELKDELEIEMAIRSLISFCTSWELPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY33</accession>
    <name>A0A2T6ZY33_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY33"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY33"/>
    <dbReference type="OrthoDB" id="5340391at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="90" mass="9983" checksum="574BDF4BE9E75163" modified="2018-07-18" version="1">MSGQIRSVGCFTNGLKFLKVQKINIQAVVAGVSLEDAKERLVEIIQEWDKQSETKPKPVELQLGIAINPLKGIGVPFPYTSLRSRVTAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYK0</accession>
    <name>A0A2T6ZYK0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1079236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYK0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYK0"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="29"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU80572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="349" mass="37841" checksum="8BB384DA9BD60ECB" modified="2018-07-18" version="1">MIALGLEGSANKLGVGLIRHTPGKPAEILSNIRHTFVSPPGEGFLPKDTAKHHRSWVVTLVKRSLKESAVKVKDIDCICYTKGPGMGAPLQSVAIAARTLGLLWGKPLVGVNHCVGHIEMGREITGANNPVVLYVSGGNTQVIAYAEQRYRIFGEALDIAVGNCLDRFARTLNISNDPAPGYNIEQMAKKGKNLVELPYAVKGMDCSFSGILAVVDMMAAQLLSGKPKPLLTPEGEPVTREDLCFSLQETVFAMLVEITERAMAHVGSEQVLIVGGVGCNERLQEMMGLMARDRGGSVYATDERFCIDNGIMIAHAGLLAYKTGFVTPLEESTCTQRFRTDEVLVKWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYN8</accession>
    <name>A0A2T6ZYN8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1171181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYN8"/>
    <dbReference type="OrthoDB" id="10387932at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="27247" checksum="7E861C05A283B29F" modified="2018-07-18" version="1">MAHKDKLLPISPALSAGTIIFLVVLSAILSLIAYTKDIKNVNITSTNTSNIGFSTMHSNTTSMAATTPAFLQLSSLDLTFWTQIADLSGPSAPEDQSKLNSTRRAIDSLLLRYSLHTLTPRDHLIVEYKPPPVYECDKLNYWTRYADAISAMSRLMLKKNYTCLGNWIGQECTEYVTWGTARIELCSWHTKNHWLSCGEVAGYAFEVVEACKEYRGAEGWAYTAGWRVFHTSPKGHKSKVYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYW3</accession>
    <name>A0A2T6ZYW3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYW3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="12606" checksum="593EBE0AA51E75EB" modified="2018-07-18" version="1">MRLLYCFLYLSLTYCFLGLSSPIHFASPFRFIYCTRKVSLYMLILLLPSFLPPLASSVIRSFLLFSLLLRGSRYLCFSFKTYISVVFDLLLISSSSYAFSGKVSSVLLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ08</accession>
    <name>A0A2T6ZZ08_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1020974</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ08"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ08"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="199"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="349" mass="40412" checksum="CB4A6B0BAD29F6BE" modified="2018-07-18" version="1">MDFASVMAAEISKKRKPEPASSKSSAEPAPKKYMKRSEIEAQRRREYEEEQKRLERERREKTERKRQEEEEERNRREATKAKQKQLAEEKRRRKEEEEEAKRLEKEGPLTKGGSDGSDEANSSEAMTEAEAIEKLRSMGEPACLFAETHSQKVRRLKRLLAALEIKNREATPPLSEEEMILNPDDIPNDKDKVYRQLAAWFALVLSEWEIALESRPAALKDSFQGKAAANSMIQAKTYMVPLFRHFKQKDLHEDIYTKVCEIVVEAQARRYVRANDVYLRLSIGNAAWPIGVTMVGIHERSAREKLHEKGLAAHIMSDEVTRKFLQSIKRCLSFCQTRWPPEDPLQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZE4</accession>
    <name>A0A2T6ZZE4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1122899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZE4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZE4"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="13589" checksum="EF0888FBF8C33390" modified="2018-07-18" version="1">MSNERHRLVVGGMFPFRFGSRYSSRWIKVDFGTTYSGLAYIHTTEPDYKNIEVIDSWPGRGNTNHAKVPTEISYSDKGATWGYDIPRTGSTTVSSAFPTVQSVRLRGRTGRTTARSPSFSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZH4</accession>
    <name>A0A2T6ZZH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1078452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZH4"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="12388" checksum="353FB6482E605246" modified="2018-07-18" version="1">MIYEEVGKREDTLIQFVDRITAIYEMANESGILVLTFMSGALGKKKRKGESSEGYLNHHEYGDLRRIGTALKKILDLFAIGNSRQSKPLLELIVTKGRVGTTHCQLGKAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0I4</accession>
    <name>A0A2T7A0I4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_972193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0I4"/>
    <dbReference type="STRING" id="42251.A0A2T7A0I4"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="6">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="144" mass="15622" checksum="2FDD56FB69F067CA" modified="2018-07-18" version="1">MGNVRTARLSTSMPARAAIVMNPRTDQSGSLMKIDISQRAVKRLKEIQLKDSNANLALRITVESGGCHGFKYTISLSDTFDEEEDTVFEEGGAKVVMDEPSLGLLKDSTIDYTTELIGSQFKIVNNPHATSSCGCGTSFDIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0S6</accession>
    <name>A0A2T7A0S6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Splicing factor U2AF 23 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1077280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0S6"/>
    <dbReference type="STRING" id="42251.A0A2T7A0S6"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="17491" checksum="C7E9BC68E277E168" modified="2018-07-18" version="1">MNPSQLQNHFDAFYEDFFCEMCKYGEVEEVVVCDNNNDHLIGNVYARFKYEEDAQTACDALNARWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKEPSKDLERELELGMKKWLRARGRDKRSVSRSISPNGESRRRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0T0</accession>
    <name>A0A2T7A0T0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1043267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0T0"/>
    <dbReference type="STRING" id="42251.A0A2T7A0T0"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="361" mass="40709" checksum="D5C0DACD1F344CD6" modified="2018-07-18" version="1">MVAEDVTGEVVGDTSARHYNGGDGDSKQSEYELSTLDGSIFDSDGSSIASSMSSAVRSNSSILSNVGNYKFEHDRRYHSYREGNWVLPNDQQEQDRMDIFHQMALLRMDDKLHLSPLENPRRILDIGTGTGIWAIEMAFKYPGARVIGTDLSPIQVSPPANCSFEVEDADSEWVYPTNNFDMIHTRQLLGGISDWRMFFEQAYAHARPGGWLELQETPPEPHNDGPTPPADLPFLRVFSLFTEASASTSRPFADQVSQFTSHMKAVGFVDVTSETRRLPLGTWPIDPVEKEIGRYNVLNFLEGMESYTLALFTRVLGMSAEQVRSLIDEAKKDVCNRKLRWYFDLVIVRGRKPYMDEVVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A127</accession>
    <name>A0A2T7A127_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1019571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A127"/>
    <dbReference type="STRING" id="42251.A0A2T7A127"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="11612" checksum="AC0F3A3662DB0C49" modified="2018-07-18" version="1">MTEQTPRINAPLLQQYIGRTIRLVGKVSDVQGNGATLDSSGVVTVYLDRDSNLKIGNAVEIVGKVNPDLTVKVLTSTDFGENLDMRVYEDLVGICQQYKEIFYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A173</accession>
    <name>A0A2T7A173_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1077024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A173"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="271"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="571" mass="62917" checksum="735CAC9C4BC56564" modified="2018-07-18" version="1" fragment="single">LEMNSQSSTCRYHPPRCHTPDTNDEFEEPPPGLQSPGSGMLPPGNPQMPGGPQVPGSPQMPGLSQAPGYLQILSNPQAPGNPQTSSNPQIPHNPQIPGNQQIPSQQQIASSSQMTLYPQMPSNLQISGYPQMPSYPQMPGNTQMAGNPQAPGTPQIHSNPQMAYPQMPSNLQMPGCPQFPGYPQMPGYYQLPGYPQIPGYPPVSSYWHPELHLYPLVQHQIYGSALPPDNSTPSCPHTTSLNPNVQSPGMGNVGSLPTAPPKVSPGAEIIIALMGVTGAGKSYFIREVTGNSAVEVSGDLYPCTNKVQSYSFEYAGARITLVDTPGFNGMNRSDTKVLRMIGDWASEAYRNSQLLSGIIYLHPITHTRMEGSTLKNLRTLQSLCGQEALENVLLTTTQWSRVNWVEGEFRESRLRIREFWGGLIEKGATLQRFAGTRASGLELIHKLMLNKRKPLHIQNQMIKQHMTLLETDAGKCINELLVEQKKKHKEEVESLSLEHQEAMKAKEDEMNEILAAEQAKAQKKLEEAAAEKELLAESHAAEVKKREAEERERREEAAAYTKSLEEQLVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1N1</accession>
    <name>A0A2T7A1N1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B9Z19DRAFT_581012</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1N1"/>
    <dbReference type="STRING" id="42251.A0A2T7A1N1"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="19">
        <location>
            <begin position="325"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="50"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PUU81627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="485" mass="52554" checksum="80FD00186F0326B2" modified="2018-07-18" version="1">MNPRVLLRSPGFLPERQLLKSSTQSLTSHLARPPSLNFQKSFLFVASSPSGNNGRRAFSSSSAGRFIDGEGGAVGGGSGGECRKGDEEVEGVGEGGEKGWSCGEEDGNEGDGRGSEEYKGGDVSSDNGSRELQGSSDVGTLTPWYHEGIGQSPAKRPPEPSVTTKGKLLPTPSRLLKLLLPLKLAGSPIDSPLTLLVHPQQPLSYLERLIQAELPPITSPDSTPRPPNISFKALNLGNAPPEAQINIGSEKGLQPLRGEEGEGGVEINRGLGSLNPSERPGEGGYVCWSTSTEVGDFIRSVARGKEFVIQVEGRDGVPVGMPSFKQRTHYLRQRLVAVMREIELQVRLKSECDRIARRGAQRVAVSGFLGLVGCLTAVCWLTFKASLGWAVMEPMTYLVGLSTVVSGYLLLLYNNRQVLSKRQKLYREKGFDMDEWEELVYEGKALRREIRAIAEEHDVGWDERSDKIGGDKVVILSNEGERDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A235</accession>
    <name>A0A2T7A235_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isy1-like splicing family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1076334</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A235"/>
    <dbReference type="STRING" id="42251.A0A2T7A235"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="19965" checksum="64619D6BB03B4344" modified="2018-07-18" version="1">MSSERVITEVTAIPAFEKGYLRQGHEYSTPLLDYRIRHLNTDIDKLMREKHMWEVQLRNLGGPYNISFCPKTYLEGGCEVPDSRGYKYFDHARVLPGVKRLFYELKPSKRAADGKDQERRLRAEKRGGMWMRITTASIGMRIMGRRRWCCRNVERAGEDGALQGWTPIPGVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2G0</accession>
    <name>A0A2T7A2G0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trehalose phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1076047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2G0"/>
    <dbReference type="STRING" id="42251.A0A2T7A2G0"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="151"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="368"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="608" mass="67268" checksum="3AC61D44308EC0EA" modified="2018-07-18" version="1">MLYSVQHNVKFVGAGVTVGLEKICPGICACLWRELDIVGVKLEVQSKTISAFKDAGTVPVDVDEQADSAARKCVMYFGPKHNPAVAIAFRNRVGPDAQGAIRLVEGLGEYEATVHKGTWNTVLKYASELKGYKNGLTERDLQRPPTKIAFFSATPQGGGVALMRHALVRFCAELGLKLEWYIPKPNPKAFRITKTNHNILQGVADPEARFDEDKQNVLNEWIGTNAKRYWLTSGGPLAPGGADVVIIDDPQMPALIPIVKKVRPEAKIIYRSHIEVRSDLVDRPGSPQEQVWRWMWDYIKQADVFISHPGDKFVPHDVPLAMVGLMPACTDWLDGLNKPLREWDLKFYHHDLRNSCNELGMNQLLYPAREYITQIARFDPSKGIPDVIESYRKLCARVLKDTPEKHPPQLLLCGHGAIDDPDASIVFAETMELLAQPRYSAISKDVVVMRIGPSDQMLNALMTTAKLVVQLSLREGFEVKVSEALHHGKPVVATRAGGIPLQIQHGKSGFLVDVGDTDAVANHLFDLYTDDDLYAKMSDYAKASVSDEVGTVGNAACWLYLAAKLARGQVLKPNARWITDMAREEAGQPHELGEPILPHGGIDIKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3A9</accession>
    <name>A0A2T7A3A9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1099291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3A9"/>
    <dbReference type="STRING" id="42251.A0A2T7A3A9"/>
    <dbReference type="OrthoDB" id="5419542at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="300" mass="34320" checksum="C14235E84C609ED8" modified="2018-07-18" version="1">MERGKKPPLIRSNTGNLGSSKRHQILHTSPSLSFPFHLHQTHEDTSRSKATAVSPDVETYNYEYQPNRYPASLPTSRKGSLHHEMPERKISVPRNKSTFSNTGREELSCAISTLQASSQKQMQRLDATYSSVLQKLHELSGLAARLQGLGEIAKSTVQEFDAADVRCRSEFKSQIKGIERFNDELGNIELLRERLVAQKERVREYHERLDKVQERIDRHKEMEVVWRRRASRRLRLLWGFISILVILWLLATAGSDPETLQDDPLRALPRLTIPTPELARELPDISIVAPMLSDEALNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3H3</accession>
    <name>A0A2T7A3H3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal targeting signal receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_968896</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3H3"/>
    <dbReference type="STRING" id="42251.A0A2T7A3H3"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="490"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU82269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="638" mass="70355" checksum="10D64EC70055ADAB" modified="2018-07-18" version="1">MSFLGGAECSTGRNPLAQFTKHVSKDKSLERDRLGNLPLGPEVGGLRTVGGEMAGADKQMMDEFYSQQSGASPFAFESMRRELSDLQHGPAPMAGQPWASEFGPQQAMNPQEQAMMEAAFVARNKSSEFNTAEFARFQNSSPSGDIQMASPAPTQAASTPYYQQFRGYNNFNQGLPFQVHQPMIQHLQMQNQQQDLKGKGKQVVELSDENWESQFKEMEAVNKTLDADDQANKDIEAELNSQPETMYGDFQSVWEGIQAETGGAALNGVDWQNEYDTSNPWSAEASATNSMPNLGEYLFELDNPYLMHEDPFSEGKRLMESGGNLSLAALAFEAAVQKDKNHVEAWTELGGCQAANEKETPAIRALEAALRLDQNNLGALMGLAVSYTNEGYDSTAYSTLERWLATKYPQVTEQAPPAPASTLDRMAIHERVTNLFIQAAQLSPEGTAMDSDVQVGLGVLFYGAEEYDKAVDCFSAALTSTSTGSSSPEHLLWNRLGATLANSGRSEEAINAYERALTINPNFVRARYNLGVSCINIGCYEQAAEHLLGALAMHKVAEEKARQDFSEVGLDPARIVQNQSTNLFDTLRRVFSQMGRRDLAELVTNGMDIDVFRFVSFAPSSFPRTTPIDARYRKEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A454</accession>
    <name>A0A2T7A454_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1112814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A454"/>
    <dbReference type="STRING" id="42251.A0A2T7A454"/>
    <dbReference type="OrthoDB" id="2537141at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="380" mass="42626" checksum="33A9ACF93C72AA7F" modified="2018-07-18" version="1">MENCMDYLSSPTPLGRGRSNTSCLKQSEKEDGFFPSTPRAGLLGKPGTSSWDHTRIQEHSGANAVTKPRGLREGEGLFASVIHERNYEKQPRRKMREAKRGTEGNRKRKRDKRKLGENIGRGPKEARAEGRMLKRVLSSGGKHRDRLTLPPTHKAGLFKKGRASRPIKSGLSDLVFSEMRFLAEPGEDQVAKDPARIVPRREGRLCRPLRLEESHRDRAQKASDIARLDNRAHAREELESKINARRRASNTPRESSLTPKESVSSPDGDSQGSFAAPPALLPTTNLASSQARPGRTSKKKPRPSTVKASVTMTSQDLRIFAEEKPRDYHPRQSQSVSKSPVVRGLVRKGEPQKVEDEEFVIEDYLDRVTEGRNDGEYRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4R5</accession>
    <name>A0A2T7A4R5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4R5"/>
    <dbReference type="STRING" id="42251.A0A2T7A4R5"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="267" mass="29499" checksum="B0EB628D7B9CDE59" modified="2018-07-18" version="1">MESNIFYTILKAIQSGEPESLEFARLDPEESALVVESLFNPKNGLERYRFRVHLSSRPFAPDCHLRVVIPSFLHEAAAEWLLCQYGRWGVTGLINDVADEAMIVAPSARITNFTGNYVGSVKEPDLSFVPVSPNGLLRDFPSVILESGWASRGPDRVDECRLWHEGSGGRVRVVILVRLYRADAQNQVRVTLKISRTTPPGTVATVTRQNLFPIPALLPPDPTLTMEELFGGQCPPGLGPRTTFTLEVGSLRHIVETTLISDGYCPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4T0</accession>
    <name>A0A2T7A4T0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_966603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4T0"/>
    <dbReference type="STRING" id="42251.A0A2T7A4T0"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000217">
        <property type="entry name" value="MFS lactose permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="524" mass="57897" checksum="DF60F7708DBB2F8C" modified="2018-07-18" version="1">MFSNAEYVEGRDETDSNDARENAISTHNIDALVRTNKSSLLSKNSLKLYLCLLVSYLVSTMNGYDGSLMGAVNDMKQYQKSFGLNGKGSSTGIVFMIYNLGQIAAFPAIGWLADGYGRRWGMFVGCVIVIVGTAVQATASGLGQFEGGRFILGFGAAIATGSAPAYAVELSHPAYRGTQAGLFNVCWYLGSIIAAWCCVGSNRHMDNSWAWRTPTVVQAAIPAIVAALIFFLPESPRWLIAQGRDEEAIEILAKYHGEGDRHSPVVQIEFQEMREHIGTVSSDKIWWDYRDLVNTRTARYRLGLVIAVAFFGQWSGNNVVSYYMPTMFQQTGIESSDTRLVLNGIYPVFCMFAAIWGATLLDKLGRRPMLIGATAFTVVCFSIITAGTAVSSTSKGASYAVIAFIYIFGMAFSWAYTPLQTLYSSEVLETRTRAKGSGLNFLFVNIAMCVNTFAAPVAMEAIGWRYYIVFIGWNCFEVFVIWMWFVETAGHTLEQMTEIFESDNPVKRSLETKKRNKNRGNSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A501</accession>
    <name>A0A2T7A501_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1074048</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A501"/>
    <dbReference type="STRING" id="42251.A0A2T7A501"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015452584" evidence="9">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="22971" checksum="35F2A7B08F73F3EA" modified="2018-07-18" version="1">MRLITSTLVSILASALAVTAHNIQLHAHSRECFHETLHKDDRMTVTFQVGDREFGGAGNLDIDFWIQDPSGTLKVSEHSVSSGDHSFEAHLDGRYTYCFSNENSGVGTKEVSFNVHGIVYVPEEPESSDPLEREVRNLGEMLNQVKDEQEYIVVRERVHRNTAESTNSRVKWWSIFQLGVVGGNGVFQVWYLKRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5H1</accession>
    <name>A0A2T7A5H1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_966154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5H1"/>
    <dbReference type="STRING" id="42251.A0A2T7A5H1"/>
    <dbReference type="OrthoDB" id="5419690at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="888" mass="97271" checksum="BE53B4CCB544C439" modified="2018-07-18" version="1">MIDEEEQRLEDIGEEKREDQPPIEESQTQDNEDGTKADNAATAEEEDGGVAVDQGENKNEGESGEGERSQEGKEGDDTPTPSENIDNTDVTETSDPEGATESATQEDPTAVVVSTEEGHQNPDIGSAPGEAEGDNPPSPPASTPTPHEGDEQDTPPEDQPPVDSVEAAQEGERKEEEKESPDSKANPEENPAHTDPDPGLEPANSEKEDDPSNTSEPPGDPGEVAVEESLAVPEENTNLAQVETESEPESKDEQQGEEKEVATTEEENQESPEAVEKQSHQVESTVDNDNDNPLPAETSVENPDSEDPSPPADQIPVVQGAEEVVETFPTEPNSTPLETPESAPASDLIEPPPFLGPMSSQVSTMPGTLVEDSSQFNLTSGEDPFIDHPHSTLDGPLDDETAAAAAAAAMAISAADAPDIGADKPKHRKSHRRREKSEKPEKERKHRDKSEREHRDKSEREHRIREPKEPREKGEKGEKEKRHKNPEEKASKETRRAAKLAAKFGAVPPTIAVVDDEAVNGQYDLPLSSVEDKTKRRRRRSKVGISADGEPEVTLAEEQPEKGERHRRKFSSKKSGGETDVEDGKRSKKKSSHAHMTPEEREERRKRHEEKALRKGRELEERLKKGSSKEGKESKEDRERRKAEKAARRAAKAEATIINGGGTVINGEGTMVNGEGTMINGKGTVINDEGTVIDGGATVINGGIEPHDDQTVLPEPDAEPGPEARTELGFDLNNPYPADPEASQLEPPSEFPASEFPESEAPALYLSPEEARAAKEAKEARRAARRTRKAEREAPKDSGHSFSSEGKREHRHLHYDKKQREEARRARKGEKQRGQSMDTSAVMFPEREGKETRGKKTKRRGSEAVEKQEGGEKQKFSVRKTLSRLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Y2</accession>
    <name>A0A2T7A5Y2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maf-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_904692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Y2"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Y2"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="25126" checksum="74778DEC97393284" modified="2018-07-18" version="1" fragment="single">PPPLDLPALNMIRGKRVILASASPRRKQLLSQIGLTDIEVIPSSFAENLDKSRYEAFEYVLETAIQKCLEVYKREINNQVKGEPAIVLSADTVIVSYTGEIMEKPRSEEGHLAMLKALRDGPPHKVCTAVVAMAPLETLVHPGYAQENHVEETIVTFDPMVTDDLLEAYVKTREGADKAGGYAIQGAGSILVKKIEGTFDNVVGLPLRGTLKVIERVLSNDEMVEEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6V8</accession>
    <name>A0A2T7A6V8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_964135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6V8"/>
    <dbReference type="STRING" id="42251.A0A2T7A6V8"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="650" mass="75036" checksum="D541F9B8C1E6F76D" modified="2018-07-18" version="1">MATIQTKPRSGQPLDPPHYTELINRYLDSGHSIYITTENFTVARGQMLANTSRAIVSLMRVPFSPYFDTKFILKWFRTANFAQAPVEQAELEAGSLHHAAEAFRRNNNFSRAPRVYTIRANENYIAQECIPGRGFRDGRPRWWPKERLIRFVRQVAVARLALLSQVENQLGVPRHAPDGQRVGPFCANVWWRDNQHRFWNEINRGPFPNRHEQILASLRRELLVARWRGDRHDLLPSRSHFNRWEDTISYLETAIRNIDQVPRPTSQELFSLNHGDLRRGFNIMMRGSKLVGFIDWEAAAYDPLPICVMDLSHRTDYNPREWRAHAGPNGENFHVLPYRLETENMEGRMERLTREGTERRSFPDWELIENNGGPLGEEDFYGDDYPEDISSADDESIIDAAEMHCDSDAEAEESCVFPEDPGNRRPDENQRRGISPYELGQTWYYQPVYALMREFIHHQRGAGLGPNGEWGRLPEAYSRPLAEWEDTLYYRVTQQFFEGLQYQLIDEDRVDAEPRLAKGPRAKKSKKQPRQRRVPTVMDGWRDAAAAGTEILPESPESSSDSWAKDRVPRRIRPSPPPKSRRVGPNPDPIPVSTLQKEQALKRVKQWGKVDPPSVKLPPAGARVRGVRDRIAAKVMEKLRDRLGRGADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7V5</accession>
    <name>A0A2T7A7V5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7V5"/>
    <dbReference type="OrthoDB" id="5378096at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="411" mass="44549" checksum="E38B14665A8E78E7" modified="2018-07-18" version="1">MSDSPPPKRHCPSGTRSLITYYPTNKYSPHISHSPSHSTAPYHYPLSLLPLATIRAYQSREFTPLRVPCRKCARPAEIGLILQKLFFTVERLVSGGAGKLEQKEKNEENNWAVNYEAGIPEPTLFGGGGFKSGRLADSPYFPFEGERGVEELGLFIRSLYGVVLDGDGDGGGGGNGGSGGVTKWKREEARLETLRKPSKTPRKTTPPVSSSPMFSTTFMSPPPSRHSETPAGTPEEEGAIPDFKNLSVLFTLLDKLERGSFAAAQMMNAFADVVIGQRCSNCCEPEAKVSPVSTGTMAPEGEANFESGDDSSRTVSAERAPPGYTSPAGQENGSTLQSTPEDYSLPSTPISGLTAKVREVTCNLCTPKRDNSVGPKVSRWYASITPRAERRIRLENPGEDVRATIKEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8P3</accession>
    <name>A0A2T7A8P3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8P3"/>
    <dbReference type="OrthoDB" id="10538038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11053" checksum="2333E5851D595535" modified="2018-07-18" version="1">MISATHTIIIVLVVMTTFSLLLLWAGLKYIESCAQFLGIEQDDFFDDDDEEAGGENGRAIPEIVVPLPAVAAATGPVMVGRPMPDGAGGMVVPAAAAAGGRDGIRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A921</accession>
    <name>A0A2T7A921_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1070453</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A921"/>
    <dbReference type="STRING" id="42251.A0A2T7A921"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="41"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="290" mass="31669" checksum="6D4AEEF0A145C5A2" modified="2018-07-18" version="1">MGGVSRNPSNASRSPRATTPVPRPSAPGYSLDEHKGFREIGDYMSRDGDCILLRRFGILRFRDVLCKQAQVEEVERQLIEADSVVLSGGGDVEMVKGLMKELDVRLKAYDDALDRCRSAYTMPPPSTYSLNEARIWLRTRGFEWYLPKDYEDVITFDQQLVTDGLITRFATLIARRVFRKDVSRKAGVDQLPSYRAVYVSRALISFIAPVILLVPVVALCYLKLLWQQLIVVAVATILSSFVMMVAKAGGAEVFMATSAYAAVMVVFLGAVANVGNGGGNKGGTGAGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9U8</accession>
    <name>A0A2T6Z9U8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000676">
        <property type="protein sequence ID" value="PUU72194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9U8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="368" mass="40504" checksum="D6E4F46CAC3C3532" modified="2018-07-18" version="1">MQEAGSLNWGRSLNWVNWPLKLGIQSLGTPDHSDQENDNNEVEEEDAEDEEDNEDEAEDHQESRGGKSRLDWVELDDTDDENDEEQEDDEDNEGEAVDASLVLMQSRGVRLHPWDQELEEELGRSSSDSFIAGSCPGPLMPSEAEQVRYIREAISNRPGMSRLLTKETRQHIGLYGAMDSPPAGLSGTFVECPAAPLLPINPTVPPAPRNSYVVTIAPALTMLNTASISPPSTTSNPSMPITHLSPVNPIVPLAPGTSDDGSIAPTSTTLKAASFSDHPQPPILQCFPRFTLLLYLPRCLTPKTSAPHGHKDPEAAATLMKWPDCQKMNLDIWRMFFGSVFQAISDCDTVLWLNCLELSLQTRSSLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9Z0</accession>
    <name>A0A2T6Z9Z0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="9" type="ORF">B9Z19DRAFT_1097684</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000612">
        <property type="protein sequence ID" value="PUU72256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9Z0"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9Z0"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="8">
        <location>
            <begin position="204"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU72256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="292" mass="31368" checksum="72244652E5477E3B" modified="2018-07-18" version="1">MAPATTNLFDATTQDMEMLLAAQAHMGSKNLQVHMDPYVWKTRPDGVNIINIGKTWEKIVLAARIIATIDNPADICAVSARSFGQRAVLKFAAHTGATAIAGRFTPGNFTNYITRSFKEPRLIIVTDPRTDAQAIKEASYVNIPVIALCDTDSPTEFVDVAIPTNNKGRHAIGLIWWMLAREVLRLRGTIPSRDAEWDVMVDLYFYRDPEAEEQKGVEEADKIPGAEEAVVEAGGFSTGGGGGGDWDAPITAGTFVPPEATGTGTSWDAEATGGEWAADTTAAEVPAVTSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA07</accession>
    <name>A0A2T6ZA07_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_695142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000572">
        <property type="protein sequence ID" value="PUU72328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA07"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="186" mass="20884" checksum="CFB948051322714A" modified="2018-07-18" version="1">MSLHPKFSFAAKYYFLNNSEKGQDRHTWHEQNRNIRKMQVSPAHGIIFSFQSSSEERRKPAGLARRASELAKVPYGRVIRKPYSTSSNPYSSSLFFEVSPHDAKTPAVSFTAAPGSEGATASPFSLFFPVKLSQDPRGRNTMRIIGDITALLYCHLCREKHNNGGWSERANRHSQADKSPHATLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA69</accession>
    <name>A0A2T6ZA69_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1137872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000561">
        <property type="protein sequence ID" value="PUU72359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA69"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA69"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="2">
        <location>
            <begin position="3"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="7731" checksum="C666BEDBF5908E06" modified="2018-07-18" version="1">MPSYIITVKPSASDSELAQIKQDILNQGGKITSEYTILRGFACDLPEKHYSTYATHPSVQSVEADGVVTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAD8</accession>
    <name>A0A2T6ZAD8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1137608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000537">
        <property type="protein sequence ID" value="PUU72433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAD8"/>
    <dbReference type="OrthoDB" id="5400587at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="609" mass="64789" checksum="A5CFC0A286CAB61E" modified="2018-07-18" version="1">MSLAAAVDFICGPLASYLTAPIGRARAAEAPCTGNPNEDYLSESENSTSGSEPGSGIGYKYSGDCQQTRCKHLPGSPAISSLGSATARSVDRVGSAEDFESASFANPDAKVQSDQDSGFFGFPSSKRSFTIPFVSDLQSKLLAVTGIGAFGGPKGTNTAEGQLLSEFILSSAENPASSEATGSSVLPCSIKPPCGSHSANAAVSPSPRSQLASTFCPQFCRSELSSAPGTRNLSHSSNTSSPITKRRSTGIASLKGPFANFVHLPPPPPRSEQIYTTLPRSTPQWRSTPGATRNPTLNTAMADPALTSSPKSTTATPKNIPWNRVYEIHTSQLRGHLRFLKLLAANKGHSQPLTQCISRAETLLKDATTAAAASGISTAGPVPAKPEKRRRSVRFEDEVTKQGKSGKKTKTAHTSTQRPKMRHAKPSEAQIAALSSALGKRGRDEPSDSDDSSVGGATNGGRVLRKKIRKEYFTPGMILEFESSDDEDDEEFAPSGKEEEEEEEEKLGADSDSDDDEDGEEVEQDPSPSPEVDRKRSKDGGMEGKRAADNDIDRMPTGKENVDNNTTTAKDVPESSKKRKVVVVSIPKRTAPSTEEEREAGRGKRIRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAY3</accession>
    <name>A0A2T6ZAY3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1096890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000494">
        <property type="protein sequence ID" value="PUU72629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAY3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="13842" checksum="827C92775B5B39AB" modified="2018-07-18" version="1">MRTREIEPMKNQNLQLSKFPLKIRAKSRFHIAVCTAKYRESAVSILTLKNYHHHHHQQKIMENANHQSQSRNRAHAFFPVMATKTNCNHRNYATRKIKRTGFSVHGSMILYMLHPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBU6</accession>
    <name>A0A2T6ZBU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-binding region of Mso1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1069381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000440">
        <property type="protein sequence ID" value="PUU72939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBU6"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="30280" checksum="CBCDE0151A2A9BD8" modified="2018-07-18" version="1">MAYFSSILTATKSRYQTLRGIDEQDGDSEDDSHISRVLRSYYQEQGRPLPDWLGGGPPPPQNLRNNYGQQRPGMAGRGQQGGGPQNANATLSDIWDTPPPQGNQRPAFGVRHQPAQQQGLFPGDDDRSQQGGGGGNAGGAAGVAMTAQQRIKERLWGGRTASPPPNTSKPSPPPPSSVQMPLPPSMQQPRNNGGGYRPPQGPPPGQQRGGGGRSYGQSGMPWDDGYSGGGGGYSDGYDGNNFSPGFTPAGSPGSGSQGSNSNLRRGKLGLGMGLPTGPGMMRQQGGNHGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC01</accession>
    <name>A0A2T6ZC01_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maintenance of telomere capping protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1136096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000427">
        <property type="protein sequence ID" value="PUU73021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC01"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC01"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="479" mass="51048" checksum="B2CE730AF097064E" modified="2018-07-18" version="1">MTQKPGADLDKLFEGIEDASTSRPPPSAQDEQDLLAGLESLAAGHKTSSRPHTPRVSTPGVRSRTPMGRNSGEGYGGYGIPPVRRDSGDVRRGGGDNTPTLREKGSAATLVNTVEPPTSASSTVSTSRASGGGGGWGWGSIWETAASTATAAVKTAEGVVKELQQSEEGKKWAQQVKENAGALRGLAGDVRSRALPTFTTLLHTLAPPISSHEQLRIHITHNLENYPFIDTIVYGVFDRVMQQVEGGDLLVVQRGGGSKPRSSLDGAFGGPWYKGMEKRDLHATAGLQEGIKLASAAAESYAQEFLQTSDASTDSTSKDNPTRKSNIFLSIQPTIYSQQPSTLTPRGKEPAEESPEEQEDQVVVFAIHLFDPVHGISYSTVSQALPAQWLEWLDAPPPADAAPGEWAVPDVIRNIMDIGGIDPREWIVEWVEEAVGLAVGVLAQRYVAKRMRIGDSGSHDGMKGKEVSTGGEEARAAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC14</accession>
    <name>A0A2T6ZC14_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CoA-transferase family III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1007066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000438">
        <property type="protein sequence ID" value="PUU72954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC14"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="440" mass="48050" checksum="03EB69A0C6CBA562" modified="2018-07-18" version="1">MHFHRPSLFPGSRRLHLRLRRGYSTSSPGIADSSGLKLPLRGLRVLDLTRVLAGPYCTQILGDLGAEVIKVEHPTRGDDTRAWGPPYAPSKDGGKGESAYFLAVNRNKKSLGLSFKHPSGQRILQRLAKTSDILVENYLPGTLKKYSLDYQTLHQMAPHLIYASITGYGQTGPYKDRAGYDVMVEAEMGLMHITGEPEGPPVKVGVAVTDLATGLYCSNSVLAAVIARAGNGGMGQWIDVALSDCQVATLANIASSALISGKRDEGRFGTAHPSIVPYESFPTTDGNILLAGGNDRLYAILCQRIGRPEWITDPRFVTNEERVKNRKILVPMMAEITRSKTTQEWLEIFDSSGIPYAAVNDIQATLSHSHVLARDMVKTVHHPTCGDIKLVNTPVKYSDSTPGIRAPPPTLGQHTDEVLMDLLGFSSDEVEELRRDRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC63</accession>
    <name>A0A2T6ZC63_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1095831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000414">
        <property type="protein sequence ID" value="PUU73085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC63"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6208" checksum="4062B790245C7006" modified="2018-07-18" version="1">MCSVSANAQFNPPCQKFRAVRTLVLKSQDYPCSLETQRRAQDPPLSLCLTHTKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCR5</accession>
    <name>A0A2T6ZCR5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1095513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="NESQ01000397">
        <property type="protein sequence ID" value="PUU73236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCR5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCR5"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU73236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="263" mass="29715" checksum="4DCACE896D90B761" modified="2018-07-18" version="1">MSAAASQFPPLTQRPIANTICLFDVDGTLTPARRSVSPEMLALLQKLRTKVAIGFVGGSDLVKQQEQLGINGLNVIDIFDYCFAENGLTAYRLGEALPSSSFISWLGEEKYKKMANFILHYIADLDIPLKRGTFIEFRNGMINVSPIGRNASIQERHDFEAYDKTHNVRRDFVEALRKNFADYGLTYSIGGQISFDVFPTGWDKTYCLQHVEKEGVFSQIHFFGDKTYKGGNDYEIYEDPRTIGHSVTKPEDTIEILTELFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCU0</accession>
    <name>A0A2T6ZCU0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:ubiquinone oxidoreductase 20.1kD subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1117411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000391">
        <property type="protein sequence ID" value="PUU73289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCU0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCU0"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18916" checksum="3E61474AD2D227F1" modified="2018-07-18" version="1">MFAQRVSMVRPLAYRTLPLLSSHCTRTFITGYPRIPQKFEQYPNFDDATDPGMNGGYVNPPAEKRQFRDPYADWWDKQGRRNFGEPLHEDDDLLGRFTPEEYTHFKPRWAFAMNGIFIATMLGFCGVVYALYPDMPAVPRTFPHDGLLDALGGPGALPALPDKDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCZ4</accession>
    <name>A0A2T6ZCZ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1004784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000383">
        <property type="protein sequence ID" value="PUU73365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCZ4"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="21199" checksum="8133067333304171" modified="2018-07-18" version="1">MLLDRSDVNPKTVNEHGQTPLFIAAQAGHEGVVKTLLDRVDVSFDIPDLFGRTPLSQALKHGHDAIVKLLSSHGNPIPSLKSDGLPAPSSPGPSDPDQRPPKQCSQQGSPSVLKGTKVSDLPALPSPTTPCSPPQSPTVPNSPPTVLVSKVTSDHPLVSSHFYILSFYVLVICLLLYWFLYFLPAPRRFYFLCRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD24</accession>
    <name>A0A2T6ZD24_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1135198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000379">
        <property type="protein sequence ID" value="PUU73395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD24"/>
    <dbReference type="OrthoDB" id="5505043at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="349"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="433" mass="50274" checksum="17AF71EB1F5C47C8" modified="2018-07-18" version="1">MTTVTEKLDTSYITRLSDIEEYFIGPENPSYPGWTKNKTFIMKNLVIFFIYKELGIIISHNIGHICDGRNPEFCIIHDRKKTIPDYWLRWWIRFTGFPSTGSRAKPLGNVNVDDFNYFKQGINRKFLLVKTKDWDFIEAYQHYHLKVPTTKRPRAPTTGTSSEQNPQNKRARVNRKSLEKTESNIESEPESVTDEESEHSCENQDDGDEDSDDEVLSRIDYPGKAPTPGPDPPTPGSQYNSVPALSSEYLNSDHFSLNKFCEGGIWDPLNPKRIWSLPQSLPEQMDSNCEVYGREVAMYKDLRQNLRTLERFSTELEFSIYLKANGLKVVKQNSIVAEDDQVVISRKSKEQMENDLLTIMKEFNSMMEEKSLWEKNISALEQANISLQKELEEMKEELAREKECKKVLEKGKEENKKVVLELAEKLKEKMLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDP2</accession>
    <name>A0A2T6ZDP2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_527539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000362">
        <property type="protein sequence ID" value="PUU73618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDP2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="97" mass="10854" checksum="98AE4B37DB29903B" modified="2018-07-18" version="1">MAVSFFIAIPFLHFHGPPIGGGRCHVAHDGRQARKLARSRSVALFNPILFLGWASYHGVFGFVYLYKMFSSTCMYFTYLISSLLAIRRMVVSFSGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDQ6</accession>
    <name>A0A2T6ZDQ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1094855</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000367">
        <property type="protein sequence ID" value="PUU73576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDQ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDQ6"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="860"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1092" mass="116931" checksum="AB5CE0669F928C92" modified="2018-07-18" version="1">MNSPAQNTDYTPLEALLLFHYLLIHGARPSSFAPISQLILKNPVIKADATFHPGRLSPDALREFYHVRLAEAESEFALSDRNSNGDDKLRLVTSRLYERYRKVSLRQIQKLEERYQDLNDEIDKINKGEWDARLEDLEDLEEQARTRDRSKSRTSFDSRNKVSSPSSDRRNIPVDSMIEGTSAATGSGEMAPLPTKPPLPPVTPPTLPPIPNPIITPVKPEKPTPSVLPNVVTPQPQLPHLQFHQAQLPCPTPQMRYEHIQPALGIGASEVLGHQPSFLPQKPHAHSSTSPSSGRTSTPKILPGPMPIPPKMEAVPPPPHPNTSLPGAPPLARPQAKIEAPVPVPPPTRPPYPPITPRTSGQSVWPVTPVPTQPIQMAGQQVQGSPPSMGGLHQLADVADSRWKQKHPPPSRPSIQQYPLGFPDRIQPVTCTPIYDRTSTGPALPSGGGCGILYPPPTPGTPVPVPQHYPQTQPRPIAAAPATTFKQYTPTPAAPVQQPRQPAQASPALRVSPVSQKIAPRPSPISQTSYVSPRKAPPPPINTGTPVRAPSTPAQSMANEEEEPAIPGSPIPPRPDEISPISTPGGSPTVESPKSIAVERIRGKKRLFGENKSGEISSENKNEGSTEKSPGGKPPPKKQKHSKTDKKTIGRPLGRMSTARAPSVEPPPLRATRSASSEAEGRASRSPSAEPPQVNKPKAARPVVSPISEGSEVKDEELSEVDNDDATMASPAPARKSKDVEGKKAGNGRATRKTSASGRKADAETAEREGTVIQTPRSKTPKRKRDPSQSDVEEESKEETATVSPRKPFHRPPKLEPQSSSTNAGIGSPLPTGVTIEQQQIVVATKKFLQLSAPLLGDISSHKFANLFMNPVNERMAPGYRNLVYKPEDLKSIKAAIKAGAAAVTNASTGTPAITTPTTESIAASTPPANTSAFTTLPATTLNTPPKGIVNSVQLEKELFRMFANATMYNKSTSEIAKETVMMARDVEGMVDNFRTAEEAGMKKALSASFGPARKFVGAGSGSVGGAGSERERERERTAGTVAEEGEEGEGSTIAGAEEESMAGEGTEKETEDGGGGGQDGKKKIGRKKKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEA6</accession>
    <name>A0A2T6ZEA6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1161592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000342">
        <property type="protein sequence ID" value="PUU73831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEA6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEA6"/>
    <dbReference type="OrthoDB" id="5340163at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025332">
        <property type="entry name" value="DUF4238"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14022">
        <property type="entry name" value="DUF4238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="637" mass="73515" checksum="DCABCD34ED3BCAAB" modified="2018-07-18" version="1">MSIDNASLNEAGPSNAAKEPQARVEAEAIKDTGKSESRKPNFNPAMDSYIKFYDLESGVLDFAKVGRSYGIPDMYKDVDHERVYHVEQLLSKLESSAASIYHRIKQVHESGKSNFSITRKERNTLRKFLFVMRYRSYGFWSKYTGTIDTYERSDRNGLIEFLEERSITNLRQVWLRNLEVIIRTEIDADGEWLQIIDREMFGDDAGMYVLHMSESYMAFCEPQSSGDEFILTDNGFGIFEGPAVYDTANPKSTGDDGSPPRLGDPRYTEFHKLAPLSPRLILVLRSNFLRAEPIWKRRKKNFGQFDAKPGAISLLQDLPIKPPKVHYWLPGESKPVHTLEDELFFEIYKVKTEQVHVINGLMLQESDRSITWVSDESLVKSLHSFLGDPNFIIGMSLAVLPEFMSFIALRFQKNRLLSLWDKPYPTEGMRPLEEFNKMNEDMRDNRDLQPYYKLGGGPELFGYDNHQAMLLIRFRSLVADHSVHGPSWSSKVNRATIKFMSTFHPRIIWLHVRMWKVTANRNRRGLGDSPVTEADYDILTEPGSEDLIANCSRSSLHSSNKLIDDLVVDFLHFDLLSRLMLETSLKDMHRLHCRERLIAQRASRKEIETSIMYRDMCLMDQFGKLSPTSHSAHKLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEC0</accession>
    <name>A0A2T6ZEC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1094484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000349">
        <property type="protein sequence ID" value="PUU73744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEC0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015544439" evidence="2">
        <location>
            <begin position="23"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="17490" checksum="2D367007E24EFE15" modified="2018-07-18" version="1">MRTSSILAKLITLASIVGIVAAQRSPSTCTASGQCGSGDLGGTRANLPRTFCLSCATVIPVMDAHTTMNIPTGSLKSDPSSPLTGRNPTSTVASRGGATTKSGSSSSSRNSSSSSSGSGGSSGSTPTGGTSSGSGSGSGGSSDGTVAPAAITTAPGGSTGVAARSGGSVVAVVLLGSLVGFLESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF38</accession>
    <name>A0A2T6ZF38_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000323">
        <property type="protein sequence ID" value="PUU74093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF38"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0034">Amyloid</keyword>
    <keyword evidence="2" id="KW-0640">Prion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="206"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="563" mass="64248" checksum="49149334D3108AD7" modified="2018-07-18" version="1">MDIAAFSIQVFQLYIMCVEGYAVFSRAKALGSDSKLIQTKFRIEEHRLEEWGQYWGFSRKDTTQLERSLLMRGQNTRKIVIEALTAVSIILRDSDTLMSRYGLKKNDLDSQEVLRNLDQKLVERLTFERGRHDEYVVQINKRNSLLAKCLWGIRDKSRIERLIMELKGFNDTLELLLPRGGEKSIDWSTATLISGSDDPEELGIVAKALKELGQEEAGRIVHFRLENIRLERAAAQVLTSRPSQHLLINKNDLDFIPRRSSRERSLALCGADMVMVEWKPYQLDVSGRQTEVIAQRADNLARQLHVSTARPANWNILPCLGYFDDAAKFRYGYVNALPRGIQQYLPLSLYELLETSIPSLGERFRLAEYLAKSLLLFHSSGWVHKSIRSSNIVFFHCAVNNCPLYGNPYIVGFDYARPDNPNAQSIERSAGNNTENEIYRHPDLQKANPRRFTAADDIFGLGLVLLEIGLWKRLRTFGPGKGKEFLDKCITETDKLNPKVGKTYANAVKLCLSGSLGSKHEASLGWEKAVGNREWEDDWRNDKLAEGGKFYWEVVHQLGKCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF50</accession>
    <name>A0A2T6ZF50_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1133882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000322">
        <property type="protein sequence ID" value="PUU74120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF50"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF50"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="519" mass="57466" checksum="9771BD55A031E7D7" modified="2018-07-18" version="1">MSVRIELDNRGSLLTCLDYVTGRVVMNIANDETISAITVKMEGISRTRLTPPRIHDHESRDSKRAEVEIHRVLYLVETVFPSPEIRENTSTTNSGYTLKPGQYEYPFNIRIPINSQCMEGQGGGNLLQRLSFDKGTVDYVKDARRHFPGTLPPSLSGIPNDEAWVRYFLKVTVIRPKFYKINLRAFDPFVFLPIEPPRPPPTTNETYARRQHQFIYNAPPIVKKRGILGAFRQQEPVIYPSPRTVHFSIEARLPSPPIIVPNLQLPLRVILVKIEPYTTPVFIRSLQIHLFAFTEITAHDIRKTDKRIITCLSQTGLQSPIGYDSQPIGVEVEADKALWVNAALPDSVPPSFRTCNIWRTYHLEIMLGLSHGYVGPIELVPLTLPIQVYSVPPLPTKEHVPPLPPRTPTVQSLKVPPAPFGSSNSTKNSPVSSPISPSSPARPHSSSGGGGGWGGGDGGGGAWPGPRPSSVISVSPEDDIPPPTYEDTIAEDIGPVDGPRRRYEQEGAYYGALPDDVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFB0</accession>
    <name>A0A2T6ZFB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000318">
        <property type="protein sequence ID" value="PUU74181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZFB0"/>
    <dbReference type="OrthoDB" id="5379327at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1394" mass="150658" checksum="2D2D14DF04422708" modified="2018-07-18" version="1">MARRRTKSMAEASNSPPPAAIARATRSRKSLALPSLLETQQPLPMTLDQGSTGQRRSSRSAPKRGEGLALSPTTGISPMVTRGKQAKDESDGKDKDHEDEAPRDHWRSSENSTKRIATPPPILDARDDDDESLVDEADKKDEEHLDEDRQEDDNDYGHREEDEGTVLPGPLSTNSSPDGQGSYTSSLNGRDRMSSPSASRNCDAASAKRRRKKTRNPHISPNKQRQLRQKQKEREEKRKCDVVSSPVSTAGSGSGTFLNPYPPVPVATEGIPIPASPPPSIAPPTVNRAFEEDFGPLFNGKTNTQEASGGPDTPVDASSLNAAAAFLLETATGEGEFRESESRERVSRDSSAEVGRSVIIAPETQDEDMPDVPAQPDASLLNVATNDLPIAESPSNQLLAEQQKNGDYATESTLSGQVSPIIAGVSTPATTVNEIAGSRHARCLGGESPRSQASPVRGLECSKTSGTSEKDILNISFGRRLSLGPSCADISENSNASTGDNTVKENNTKSRESNTRLVVRDGPPSPKLERRDTESSVGGIGSPIKITSPRERIEIRVQLEDRDLDSVTTDEVNAAASVLLQMLNPNNLVSTIGRKRSHSEISSRGGGSSPGHRASSKKLPCPTCSITVEQILSCLERKSAGDRRINLEEFTDKHRELCAKNFRDESLVSEEEMEEEDEYGDYDEEEGDEGEEGDAGEGLDGESEGEEEDHAADGDEELVEEVDGVIQKTVPAASGAGEALRKMAESLPGYLSLKPEDVDREIEIRRSAITAGRLPEGKSIEDILFIPITPVSAFQEYLENSKTLAEKFLVEEKIVEALADMQAEYWMIDEVIKRKEASTPDGERATIGKPVRGRQKRKPRVARNPLEPDDPVVWEDKKEAELYGFSYDPAIDKRGKQNADEQQAGKYSIRGRELRSRQKAVEMVLYPGYEHIDQRVQTIQPKATRRRKPAADKEKSGESLEQLRAGSAPPPVSAAPQKKRPGRPPKNASSALFLSAAVKDQASAQALSRTHSADNVARPRVGEKPKVDPNRTPPSSLSGTLVRSPPNCLKIKFRGARLAEYLNIVSQESNLASTQSDFYSRPGPSSLVPATTQSEPVSPTRFYPDKPTRQSDSFMSLMNGGVGGQRSESPVYDSAESNLGEYEGVGRGKPRSRGRGRARGRARGTRGPGRPARGSGLKVETSNAANPIGRGEPLSANPETPTLSAVEYSEAEDAAIGAASDRGHNYHSNAFQALPKAPSSAKHSTPAVMRFNSTSTPSMFSVFPTRLGQHQLPSTSTSPTYNDNRSSVETDHGRPRVRGKTYKTPTSVSLTEAQPKTTKEEEFIAAQNGNLGKRKRVKTALAYEAPRRKARAVAGRDGAVGGGHSPGSVSGERDDETDSSEPDDDDSGGYGNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFR6</accession>
    <name>A0A2T6ZFR6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000308">
        <property type="protein sequence ID" value="PUU74296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFR6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFR6"/>
    <dbReference type="OrthoDB" id="5352953at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="130"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="37169" checksum="AE2CFDF848BF4021" modified="2018-07-18" version="1">MTPARKSIPQRALGNVLVTWADMFLSTFYEEHRKKYPEADLPCFPLPTQASLRYKICQVTLCDALLAHAPDSSSVAQHLLQNIFGPKSMRNLENIQTVNNKRHFPDLTTEEFNQLISQKTRCLIRDGYRCPLTGAYDKDRPYLPETVQTAVHLDLAHIIPLQILTNPVLQEYFQTFTGLPLSHVRAASLNHPRNGLILEANAHRDFISYNWGITTTSTKTTANTIFDDPTRPNTKYKAERAYRGLLSFKMPNSLLAFGEGMRGVELPDRDSLAFHLAVGKVLHESGVGGTLAAFLKDLSAHRTRAEWGGETEDVFDALESNLSSAAGNFVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGC8</accession>
    <name>A0A2T6ZGC8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000293">
        <property type="protein sequence ID" value="PUU74529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGC8"/>
    <dbReference type="OrthoDB" id="5340163at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="947"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1136" mass="130589" checksum="36932B8F4F3EE693" modified="2018-07-18" version="1">MVGESETLIIYKPEAKEFEKRHWSETFGAENIYAPYFDNLTTSTWMREGFRKFDVLKRIDREIFNGLMDPIWQIHQQQPSGSIPLIRGDLYQLRKFLFLMTSQHSRDKIMHLLAHDPNMEDARIRRRKFIEAHGMEHPRDVWLGNSEQILDSQHCDIQNNMDIFDLDRENYRVNAKERFLVFWEAGPGEEFILTENAFGGFEGGQIGAKKNSQVSLRARELERHLYTRDFMWHQLYVLSPTLVAALCHGTLMHPELTRNQRKRYGLRRSILEGLPHDIAPKYYKDMNKSDASFLKPNWTLPAEVERAFGTNVSLERRKDDEILFPVQRLTPTQVALVNSVLLHNQQSGAKVKSVCCRSPPQYQSLYQSLVQFHHNQWHKYSEEEQNDYSPLTDRLQVYLNPEPMAAPNQLQYAQQQPFPGHPMLNSQFPMPMPDPRQLFAEGRHALSVPEVPKYEPIHVDMRPAHLRVNSHTAPSQTSYHSSGTSSFAPSSQSSHGYSSASSQSSASTRSTSIDTPRFEPKEITLDKNRQSPTRKAEQPLGRRPSHSQPEPVSRGSDSSGKTRTDKTKPKVTNTVLDRTEILGERTGVISERGRQLDPPKIEQPRSKKNSPNPGPDRLEFAAPELNKTRRQEPVIEHRQSHPKSSALPDRPIYVVESVRPNPPERTRTDPAGAQWGNTFTKQQQQQQTQPQRPAGERIPQSSDNVRQGKYEVIRPSQHQAQQHQTLHQPQPQRPANERTSQSSEHVRQRRYESARSEEQQHNTHPQTQPQRPTIERTSQSSDHVRRSQYQTVKVEYSQPQPQKPVETPVERKPQIIDTSNRDRGRQYEVRAELGQVQRPSNPSTDRSHPVERKYQVVMPEQQVHAQITVNNSNTRGQRPITKSDNSRVYHHVLNSEQPKQQQQQPQTQAQQQPQPQQQQPQAPPPPPHQHLKPVIISHDNQPLVTDEHKGRRFDTSEQVQQTESQRIVNSSTERTMRPGVEIVRPHVLEPARTAESRAQEPARVVLENPKMKHLRFEAAGKTLTHKHSDSSLAGSMVVEIGEVESQVSDGDEEEDDNGDEGSWEDEGFGELEELSKPRKPTVRFADRPLSRTGGRGMHIERPSSRLARRVEIARPLSRNSQRVENARKSRGAHAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHA3</accession>
    <name>A0A2T6ZHA3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1132432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000267">
        <property type="protein sequence ID" value="PUU74862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHA3"/>
    <dbReference type="OrthoDB" id="5500379at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="295" mass="34045" checksum="2EE08F0CBBA82B71" modified="2018-07-18" version="1">MLDKEIRKVLELGIGGGFGKGECCERKEEKVEVRSMVVVEDGLKEKEKLRKEVVVEGGRSYSEVLQGGDEEKDGILAEKKEKEIVKWLDESLERERRSGKVVEVIMDSQSGKSEEDWKVDEVMEKLGMSKNVLDKMKVTGNRIRMVMKDKEVAEKVEEMGKEIIGEALGGGVVGVKRNENWVGMVVPGMEVEMWEGRMGELKEKIEEENGIKLMREPRWLANEDRRKSMKLKRVGVIIHVARESIRVRLTEEGLKWRGKNWEEMLKLVAVRKKKDEMWHMCSGWSHELATSLWKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHB4</accession>
    <name>A0A2T6ZHB4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TFIIF beta subunit HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1132400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000266">
        <property type="protein sequence ID" value="PUU74872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHB4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHB4"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="2">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="24714" checksum="797FA63B6F76FFDB" modified="2018-07-18" version="1">MEQFSTLETFLAPQGNSNHHPQSSPYRASRKRELGDDDSQYESDPFELRLPENSDGGGGAVYCLATFIERSRKRHRDSETPGEPKETTFRRPLKANKTSFVTKFRDDLVATPVRMEGTPTIYARPEAFKKEPRYSVITAVNAQMNLLRPGTVGELPSRKGKELLDKAYRMSKNDLISSLYELFESREYWYLKEFREKLSQLECYLKQVLKEIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHN0</accession>
    <name>A0A2T6ZHN0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1054918</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHN0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHN0"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="63"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="254"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU74966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="402" mass="44490" checksum="49660A754CEA6FEF" modified="2018-07-18" version="1">MASRAFVRALRSPASRQFVAPVQKRTIVTAFSASRAAVTVAPRFAGVPVQQKRGVKTIDFAGVKEEVYERADWPSEKLLDYFKNDTLALIGYGSQGHGQGLNLRDNGLNVIVGVRKNGASWHEAVKDGWVPGKNLFELDEAISKGTIIMNLLSDAAQSETWPAIKPQLTKGKTLYFSHGFSPVFKDLTKVEVPADIDVILVAPKGSGRTVRTLFLNGRGINSSIAVWQDVTGKAKEKAIALGVAVGSGYMYETTFQKEVYSDLYGERGCLMGGIHGMFLAQYEVLRERGHSPSEAFNETVEEATQSLYPLIGGHGMDWMYAACSTTARRGAIDWTSKFRDNLKPVFNQLYDSVVDGSETKRSLEYNSDPEYRKKFEAELGEIRNMEIWRAGKAVRSLRPENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI03</accession>
    <name>A0A2T6ZI03_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FK506-binding protein</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_996189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI03"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI03"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="391"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="186"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU75115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="476" mass="51222" checksum="F0D912EA5A8FABF9" modified="2018-07-18" version="1">MSPLLPVALWSLHISPGQSPVLAVDSAPATIRVTMAAIDPSAKPYEVGKPKRATLKVLREPIDGPDSDSDSDSDSDSDSDSEEESDKGAKKIIKSSPKGKQSPGSKASSDGTSTTDNDSDDDFDSGASEPDESVTLESFIVCTLDPEKHTQQTLDLVIGDDEFVCFRVDGNYDVYLTGNYVVSPGDVYNSDSEDDGQYDLSPDEDELYPGEETDSDELDDLDGLEDPPRIQEVDTDEEEVGEASKAVVPANGASKKNKKAEKAEKAEKVDKKVDKKSLKRPAEDEEPHTIDEMIEGVKSASENKGDAEKKLSKKQLKKLKANDGKAVEVTTDSKAKEAKKVQFAKELEQGPTGSPVTAEKKVEKKPSAKRVIQGVTVIDSKVGVGSAAKKGSKLCMRYIGKLENGGKIFDKNTKGKPFTFHLGKGEVIKGWDIGIEGMRVGGERRLIVPAALAYGQKSLPEIPANSNLIFDGMILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIE2</accession>
    <name>A0A2T6ZIE2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_995263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIE2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIE2"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="18692" checksum="4B35A40D7ADE844E" modified="2018-07-18" version="1">MALASRCCARIARSSSSSLRFSPPVAYALARRWNTTTATTDPKISGIVDQISSLTLMETADLVSLLKTRLNIPDVALQSFSTGPAIAAPAAAAEEEAAAEPVQEKTMFNVKLVSFETGSKPKIIKEVKSLLGLSLVDSKKFVESVPKMLKEGLVKEEAEKIQKTLKDLGAVAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIH9</accession>
    <name>A0A2T6ZIH9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_357835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIH9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="80" mass="9292" checksum="532DDE87BD9EFF3A" modified="2018-07-18" version="1">MLRELFGTKPPLATKKNMPAQLELIQDFQHLTNSLLLEDHKKTINEYFKLLRSTYGTTFPRPDNHHITLAAAMAEWQIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ27</accession>
    <name>A0A2T6ZJ27_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1090317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ27"/>
    <dbReference type="OrthoDB" id="5335010at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18701" checksum="9D4D9961CCF325BA" modified="2018-07-18" version="1">MPSCSAPRATKTQRRRRRLPRRYSPSPLTSSATSSSSTSTAASSLKSLKSFFSNSSSGSNSSQRKHLLNKISSPFELAAGNIRKGRGRGRAMGGGMGIGIVGVGVGVGGGFLGRHKKPSTLDFRCIGEELVRVSTIRLNMFAQFGYFEDAPKIPWEFPQINDWDSNWFAHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJF1</accession>
    <name>A0A2T6ZJF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_993805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000222">
        <property type="protein sequence ID" value="PUU75612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJF1"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="19644" checksum="26399B71971A5AD9" modified="2018-07-18" version="1" fragment="single">PGPGQVTITGVTYTGSGCPPGTAHISISPDWAKFTLIFDSFGLKLPEAHKDCTLNFQVSYPLGYQFTISKIDYTGYVLLGLGVTAKQTSSHWFSGFVGDKQTFQSTLYGPYSGQYSGHYILPGPLPGAVWSPCGASTTVNINTQLFLNSNKPNSPGMINISSNGSKMQYQYAYDLNWRTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKN2</accession>
    <name>A0A2T6ZKN2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_992072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000205">
        <property type="protein sequence ID" value="PUU76059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKN2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKN2"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015631882" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="17739" checksum="CCB500D2ABF60C5A" modified="2018-07-18" version="1">MFSLLFVILIIPSLLIPTTLCVPQGVWEIIRPPGTSPPGCIDSYPAAFSFELVDHPTPGVKTHCIKPRMLKMLLQHGLLTDHLGRIGSIVANRQFQFDGPPAQVGAIYTGGWSLCSDNLIALGPQRQFYGCASGDKEFLYDTMIAKYCRTIFLKIVLLVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL21</accession>
    <name>A0A2T6ZL21_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Late endosomal/lysosomal adaptor and MAPK and MTOR activator-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_991413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL21"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15454">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17572" checksum="A14BFE6C33E69E55" modified="2018-07-18" version="1">MGVCSSCLGIRQKDDPEHQRLLAASGDHLHGHSYTNGNFPNSSHHHSIPDPQTLLHEREYLDRLVAQTSENLIDIFAPPMLTHSNSTATPNSRGEWYRSVLSKTSPPNDGPEMPVVLDPAVVGGSEREWLESVLKGGEEAVREVGRVKGVGKLVVGLDYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL32</accession>
    <name>A0A2T6ZL32_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1088780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000197">
        <property type="protein sequence ID" value="PUU76191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL32"/>
    <dbReference type="OrthoDB" id="5328636at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="637" mass="70289" checksum="34F9BC24E393097D" modified="2018-07-18" version="1">MEPPPHSNSSFLPQLSFRKPPPPPLPPIPIPGYDGIMSDDPMAIVFNLDPRLQGNRSTNPLSMPSRKNMMNRFPETKFFSSLRAKLDKFDEDTRFFGSFKSQKHQQKKKGERAPLVVRRRAGSLIPGIGSVPNSDISTPLPPPLPVKNEDKLPKHSNVFTGVPTPTDTTVHSRNHSSASSVDADSQPESPNMTHKAKGLLSLEASLKEYCYIEEPKEKNQLAKMPSAKEPQPFTNPGMTAEEVEALGNGAGSPKAEGGGSFLGAGGPEIGGPGSYQSQPWKNYVSQRNLRRQRQRLPGQSPLNTLKEFNQNCQTRTQGLIEEVLEQDQIFIPSVSQRLHSWKPEGEVKTMQERLRTSTSTSTSPLLKYMRPPIDGALAPNPQFTLPFLRSATISSDNLPRFSKKSLRVHHLRQDSELFLQPPKASSTPENLAPDSSLRSINSAGIPELDAVSNARGFLGWDTKLHNLSTYAHPNIPRRNALSPLSDPNSLTGSLIDYKGLTSFAMDYAAQMPPTPPGSSYSPSVGRSVDGDSHDWSGEDISEEEQTKVILGKAGSRLQVHPSTKGMTGFVPFLRQVCEVMLSRDESLFLMKIWYILLMVWAMWALAKLLGIGTELMQVVILEPGRILCHALKRWLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLC9</accession>
    <name>A0A2T6ZLC9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_260841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLC9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015489237" evidence="1">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="11337" checksum="A6A061844C7408B3" modified="2018-07-18" version="1">MILLQGCTIFFSFFLSFPTIQVYPNKVPETDSTVLVQNHLPHTFIMHASTIQVQNRFNVPATSRQARLKPNQTKPKLKFHLYYSLHLLPRRPFPPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLP6</accession>
    <name>A0A2T6ZLP6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1088371</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLP6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLP6"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="250"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="465" mass="53997" checksum="3A6D14F9C00B74C9" modified="2018-07-18" version="1">MSDDDFMIESDPENYDFEYEDGGEEESGDVDVENKYYNAKQMKLSDPQGAIDEFLGVVGLEKEKGDWGFKGLKQAIKLEFKLKKHDRAVEHFEELLTYIRSAVTRNYSEKSLNNMLDFISSSNDEDDMPYMERFYDMTLAAFQGTNNERLWLKTNIKLAKLWLDRKEYARLQKNIRLLHKACQRPDGSDDPSKGTYLLEVYAIEIQMYSETGNNKKMKELYNQSLRVRSAVPHPRIMGIIRECGGKMHMNEENWKEAQSDFFEAFRNYDEAGSIQRIQVLKYLVLASMLMKSEINPFESQETKPYKSDPRIQAMTDLVEAYQRNEIHRYESILETHKAEILSDPFIREHIDEVTRNIRTEALLKLIAPFTRFTLDFIARQLKIQVAEVQEILGFLILDKKIRGKINQQKGTIEIEVNVDAERMKAMKDWSAALGALSYSLFNDGDGFKSDDTGLMGGIDVGRRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMH2</accession>
    <name>A0A2T6ZMH2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_230903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMH2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015580786" evidence="1">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="9896" checksum="27A0DF2D42674938" modified="2018-07-18" version="1">MQALVLAVVVFALGALFFPLKAHDPSQPLQITLSDELTTYLSMHTGIGGFAHRLLGTLRYRIRCQILEICLVWKSVRLTSRAFFAKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZML9</accession>
    <name>A0A2T6ZML9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1194501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZML9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZML9"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22960" checksum="88597069C900EE12" modified="2018-07-18" version="1">MSRVTPVTEFITFPVKDVEKAVGSENWIRDIAKCVGCTGGNWGWQIEDGGNLHWALNWTSHSAQQAFSKQSTYPTFKEKVVGMTSGAPSFFHATLTPHEPTAVFEAPITEWCKLNIAPGTDKDEWISGFNDFKETLVLASGYRGHACGWGVEDPDMFMAVIGWESVESHHKFLKEEGGNMEWVVNISDVESMEIWHVKKGGAIPPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMZ7</accession>
    <name>A0A2T6ZMZ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cornichon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_989004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMZ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMZ7"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="16084" checksum="1C0831F119ACBD95" modified="2018-07-18" version="1">MSGEAWLYLLAVLLNAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNTYIVPEAAVHAFLTVLFLINGYWLALLLNLPLVVFNIKKILDNAHLLDATEIFRTLNKHKKESFIKLGFHLVMFFFYLYSMIVALIRDETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNL8</accession>
    <name>A0A2T6ZNL8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_198137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNL8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNL8"/>
    <dbReference type="OrthoDB" id="5409589at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="623" mass="69851" checksum="4C9DBF78A9458A77" modified="2018-07-18" version="1">MKYNRPAMASLLSCVGQPSLTPLSMIYPHQATSSENQYAPSTSSPLSPHSILLPPLETSATTTGSHYYRPALSAISSSTHSPSHPSRQFREQSLLATDALLCNLTPAKIIRLSASGEVDFEPREKELSLLAAWGTVKVNEWLDEVECWNREWRRTYRESKDAGDGYLPPADRPKKQRKRGMGGIREEEEGAMLDSSKPVGQRLYSEDNGTGGSGGVITKDDTPEVGAVEPRERKKDSPGLRRGGKPLTPYQLKMQRQRAAEVVNGGRSEPDQIFNPVEKIGAKEEREEEEEVEDEDDELYEGVEYWGSLKRSTIEGYEARIEVIRSEIEELDVDDLKYRVLSYGTSAADLLTDSAAIMTITTLQLLPPLSRLRKLLSAWVSRIAVLRIVPAFLGSLTMAKDALEAGYTAITHPSINPESSSLDGDWRGLAEESYKLMQDIITQKVAKAGMIMDTMLDVLEGREDVLPDSWIDELEDVEKGFSCWVMDGERVVLEGRLRLEEMTTRRSRGEGGAREREKTLLAALHAESEKRIDEKRETEAEHHQPAPERVESEEITKLAEAEEKTLEAEARKSPNWELKDSPKKRNLLKRLVSNSKLKKLTKLNAFYLLRKLPKKNMLRSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNS3</accession>
    <name>A0A2T6ZNS3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_988006</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000162">
        <property type="protein sequence ID" value="PUU77132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNS3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNS3"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="6"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="829"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="960" mass="106158" checksum="62EE65E38EB9BAFC" modified="2018-07-18" version="1">MFEKSSISVTVRVRPFSIREAAQVTRIEDSPSFFGDGSLIAAPPPKLTGKGIRSVVKVIDDRVLVFDPPEGNPVARYQKTIVPQGKRVKDMRFGFDKVFDENATQEDVYEATTKSLLDSVLDGYNATVFAYGATGCGKTHTISGTPQRPGIIFLTCAELFERIGLLADEKEIELTLSYLEIYNETIRDLLVPGGSKMGLQLREDSGQNISVAGLSTHQPKSVQQVMNMILMGNQNRTMSPTEANATSSRSHAVLQINVLQKPKTAGLSENHLMATLSIIDLAGSERASVTKNRGDRLLEGANINRSLLALGNCINALCDPHKSNHIPYRDSKLTRLLKFSLGGNCKTVMIVCVSPSSQHYEETHNTLKYADRAKNIKTKISRNTMNVNRHVSQYVKAIYDLRGEVEELKKRLGDSTREAMEKIVRQGSAKENSIKDGMKRLRAAFEQSKEMRRERINDLKNLRMVDRRTSVVAAWIAAFDQAFDSYQTEDPPACVLKMRAEAQKVILDLRGNHQYLQEKLVGPNWEKVIDSALQTSLRSLQAYDGVTETDVATLTCEANLLRMTAERDILHAVAEVDVDFSSIVHALSKAHFETVGTITRILESNVTEEEALELAKKSLFEVQRGASDAASHVIKPNGELVSGESYDAYRPASPRKKKFPRVSLSMASPAKPSQLPQLGTIHSASPVRYSPRPIKVKTPKKAVKFGKKKRVRWQDETEDSSFTLEEPRRKRLEEPSILYEDSSSILVAPLENEPSFSATSFSTEEAPGIMQPPIRPRNNRLAVGFLSKNRESLAAVPPAEIPLPSDSPLRSFDTDQAINKVKTNADVLSDLSSSDEAKPWRSHARPSKSAMRKSIASSTVSRLAGKRRSPSGSSQLSPDNGLFKIGHARRMPRGDKENGSMTTVLSPKSNGIKTGARRMTINGPSSGSLRISSKNAMLLGQIREGDERESMAFPGKQNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNZ2</accession>
    <name>A0A2T6ZNZ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNZ2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="22530" checksum="1185E8EA88BEEA53" modified="2018-07-18" version="1">MPGLYSISNTQPPMLCLVEPQPCNSRQEPQEIEADPFRDYGFVSSPQAPYSRGHLGHPPVVFPGYYLVAYERPQNLARNGDGSDFAGAGSGIEYRPPSTLPHPLEKDLGWQQEADAQPFYNLPGKKIWDPVGLSLYLQISRSDESDIASLEQSSPSILEGYCLSAAGSLPQTLHEASYGNQGLELYQPTPRSFPDGNWGTQQSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP07</accession>
    <name>A0A2T6ZP07_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1128548</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000158">
        <property type="protein sequence ID" value="PUU77216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP07"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP07"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="11">
        <location>
            <begin position="283"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="413" mass="45748" checksum="905627459BD6FA39" modified="2018-07-18" version="1">MSNKALILVGGPSRGTRFRPLSLDLPKPLFEIAGHPLIYHPLKAVAKVPSIKEVYLIGYYEESVFAPYIRQWSTEFPQFTIKYLREYTALGTAGGLYHFRDAIMKGNPSRLFVINADVCCSFPLKEMLDMFEEKEAEAVLLGTKVSNEAASNFGCIVADPKTSQVRHYVEKPESHISNLINCGVYLFSSSVFSLIRSAMEDKAIRLASDPTLDPSDGDTSSVLRLEQDILGPLSDSRRFFVYETRDFWRQIKTAGSAVPANALYLQKAWQSESNELSQPSAFIVPPVYVHPTAVVDPTAKLGPNVSIGPRAVIGAGARLKESIVLEDAEIKHDACILYSIIGWQSKVGAWARVEGTPMSVTEHSTTVVKNGVRVQSVSILSRDCKVGDEVRVWNCVTLPFKELKRDVSNEVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPV7</accession>
    <name>A0A2T6ZPV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1194007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000152">
        <property type="protein sequence ID" value="PUU77474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPV7"/>
    <dbReference type="OrthoDB" id="5489558at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="22403" checksum="0D9C14A7AB739FD4" modified="2018-07-18" version="1">MLLFTQLRLKLGEVFGKYSSLFAKEGTSARGFRTPRSRDRTRAAKLCLSCQAVWIRGPHDLCTNCELSPYIIPNEGFSNYPSPFAKKRTSTSGFRAPGPRDGIKPPRLCLGCRAVWVQGPPELCNSCELGPYILPVFQEDEEWTKKKKDKGGEGAVGEVPGWEGKYRYTEKAKAEDPTQYNILKGGFPKEIVKKYSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQR2</accession>
    <name>A0A2T6ZQR2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Karyogamy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1101694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000141">
        <property type="protein sequence ID" value="PUU77774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQR2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQR2"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="937" mass="101921" checksum="946ED280C5CE98CA" modified="2018-07-18" version="1">MSKDRLSPSPSPHRKFSNASSNGSVSAATAAITNSTAALKLSKELPPTPVEDDEDDEEFHTVKGDGASKIGDNDDNSSDGEGAHNFSSALQSPNNYDGTFNHASIMMTSSPPGSARPDTSYSTWTEDSRNAARFSNDTTSETQPETETRPNNSPYIASSTCLQRRASVFSLSRVSFSAQLSRLTSLSLPLSEDISSRIRQLPTARDACNALISAGDQISRWIDTAKKVLRGLDAEDDVEWAAQGRESLNEVDTAIGKFSGLVNVYVELIDELQNREDSDEVEKVLVEILKSMEEVMDGWNEVKVILKGVKDQVETAMEWTELWTMILQDIQAELDACQTIVFEEEEKRHRSMMEDTSVVDLDALETIIEETPISALPKVAKTAAEEESSLLGLMARMQPLRVSLDFLPMRLQSFQARAEGIFPSACEDLASRRNTLEKKWKKLDSDVEGLKKELGEDKWVALFRNAGVQTANMMSSVERSLKKLRDAVTIWEESEGRIDSDLALKIQNYEAKKVHYGSAIERALGLITKGVRDRITVNGEIIRLDAAMRTRWKTLGDGMADMEQDMNDLGLNVQMLRDSFSSVTSLEVRSYGGSGIITPGSSPASSVVMATSPGGIERKRSPPSAIKPPSGAINTRPSPQPRASSIPKKSQYARLSSTGSVVGASVRNSLSPITTGMVRVSSTPGASQTPPTTRRSSSSSGSSGKPADNRPRWNSSTNTNDSPFGHNFKPLNLTTPSPYRKHPPNTNRITSPTLSLPASPGASRIPGPSPLTSASLPGSPLLPGTRRTSGSVFLKSPSPAPRLDPAAGGRQHPELRRQASMSQLRHQSRDQTRHSSQESITLSTISHTTYVEEKGREREERQDLRDKENAKRSVNGRPASAMASARSNRMSMLPRPTTPGSGSGSGAAKRNSMPPGSTLTQQQAAAKADNKPRWRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR19</accession>
    <name>A0A2T6ZR19_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1101634</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR19"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR19"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="518" mass="59540" checksum="F5C63015662C7672" modified="2018-07-18" version="1">MFLNLFGQAVYSLLQHKLYFFSGILILTLAYWTHAYLTSPFRAQKIPGPFLGKFTNAYRWYYVMRHTWHRDLVDLHKKYGPIVWIAPNDISVSDPTLRNVIYGFQNHKKEFTFFKKSPSYETGSINQDFSFIFEQDPEKARLGKYHMSHFYSEQGLLNLEENFDKAVDELIEGLDKHHAKTGTPCKMVDWAEFFALDLVAQLTTDRSAGFCLAGTDINNAAYGMRVIIKTVGALMPLPWVLSATSRAIRQTLLIKFLINLYRNVLLLPTFTFDSGTADLEFLKEKHPNHLLAKFYNAQSKMREHYPHGNQAEGTTIQLFNLIAGAVGVVPHSQVKLIQELALNPEVLQKVREELATTNNSFHIKDFLRYNNRQNKYPIFESAVREAVRPPAGCQLHQYHIPPGYNVGMAAYQVNYDEGYFGPDVAQFRPGRWLEDHPTEMLEGEKRSMKNYIEAGWLSFGSGGRVCIGRHLAMFMMMKFTAAVVREFDIRVVKQPEEHFTLVTEMLGMEVLLSRKCSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR73</accession>
    <name>A0A2T6ZR73_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1065405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR73"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR73"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="54"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="704" mass="78214" checksum="DA6876E76B789D60" modified="2018-07-18" version="1">MAAVLLGGNSYDRGAGGGGSQYSPRESSTLDSEFIQEQSKSFFSEWKPVWCTGWHPGVLACATSAVVVLFINVGLATYAATNPENQMGRGVRTLYSGSCDKSKTIGLWSHLGINALSTLLLSGSNYTQQWLAAPTRSEIDAAHARRRWVDIGVPSVRNLFWIKPERTLLWIAIGLTSIPLHLLYNSAVFTSLGVNSFAVTVVTSDHFEPGAYSNLTEGMSDWGESWNPPKRYNANSSAYKDLNPSECMKLYNTDYVSSYGNLFLITQHSSNTTHNNTLLDMTYVVGYQLSSNSWLCSDYLVGDIGRVPAAPCNPSKLISKVISGLPWSIKLATGEEVEIRGCKSERTAEKCKVQFSLEIMMVVICCNLVKACCMVIAVIRSREPTLVTLGDAVDSFLRVPDPTTMGICFADRQFIKREWRHGWKTGPRQWKQERAKRWWTSVSKTRWIICNFFCLIIVIAAGVSLRLGLDHEGKYWNTDFKSIISQFWADSIINITQVILLVNLPQTILSFLYLTYNSLFTCMLMGHEWSLFSHSHRTLRVTSPRSGQRSTYWLQMPYTYAIPLMALSALLHWLTSQSLFLVLIERLGLSEEGTLPMLPGLGYSCIAIIFVLTLGILALVTAAWVGSKQFSAEITTVGSCSAAISAACHASESHPEEIVGKKIRWGDVGSTPYLGIRHLTFSSEEGVRKPVFGETYLGSRLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRA0</accession>
    <name>A0A2T6ZRA0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_122812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000132">
        <property type="protein sequence ID" value="PUU78011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRA0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="19776" checksum="9843CF4BAD5F0172" modified="2018-07-18" version="1">MDTSHRVLRERPPKSKKKRRKDSNPDPFTTQNSTAADVIHLRIPEPPKSPTPTARTSRKPKSVNVLPHTQGSGSTLKSATHDEYLLALEDAIDSLILAFDIHSTQHPEPTEEQLHERKLMDTACISLQKITKNLVGEDLEESVRKRDEHYRKMRHYTHASTATTQETISLADRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRD2</accession>
    <name>A0A2T6ZRD2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_121010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000131">
        <property type="protein sequence ID" value="PUU78026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRD2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="10518" checksum="E21A6F4F0F6EF82F" modified="2018-07-18" version="1">MRSGVSPDGACYDKSKVVPPLHHNLYTPPPPIPHVKTLPQEPIEQQLGEPSPHWAISRGPPPRQAGDSEQATSKAANPQGDSLVYTVASQAKECMSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRI9</accession>
    <name>A0A2T6ZRI9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_984323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRI9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRI9"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="416" mass="44817" checksum="0E1BE37E50C6EAC6" modified="2018-07-18" version="1">MSSPLPVPTPSPSGSGGGSGGSGPTSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNARQRRRANGEEEPVDLQTMPRPHRRRREKKLMTMDEVNERFPATKYKSWRAQRERMGLPAEGGIKTAPNSRPASLMDVEAATSADANNGTPNALAKELALPPAIDKETSPTPTPTVFADKSEAPDVARKHLSDISEPERRKSEDDDDDDEEDEHDHVQTAVPDELLNSVGDSCAICLDTIEDDDDIRGLTCGHAFHAGCLDPWLTSRKACCPLCKADYYVPKPKPEGETAADDQSRSHRHRRGTNGTPTPPPNAHLGPRRMFFSPGRMISPYYTGSSSGRPRDGSLVAPQRGPEAGQSTGGIRWMRNPLRGVSLPFRGRNNTAAPPTPSNLEAGVLNTSAAATPTGAPTPNPIPGVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRJ5</accession>
    <name>A0A2T6ZRJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Citrate lyase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1101543</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRJ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRJ5"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="308" mass="33316" checksum="0DC88649EB8942B2" modified="2018-07-18" version="1">MTSAPILRRALLYVPGSSKRMMEKARGLNVDCIAYDLEDAVTAAQKPTARHIIKDALNLPRPGGVREVGVRVNAVETGLALQDLRVVLQGRNLDTIVVPKVESAGDLTFVSNVLDHSNHPNKSSVKILALLESARSIIDIRQICTSTPRLSGLIFAAEDFAKDLSITRTPSLTEFLLARQTITTAARAYNIPSAIDLVCTSYRDIATLERECLDGVGMGFNGKQVIHPSQVDVVQRLFLPGEGQVRAAVKVLVAEGVAEVEGRGSWGLDGRMVDRPVIEAARRTVGKMEAAGVDISGVWEAEKETKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRL4</accession>
    <name>A0A2T6ZRL4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRL4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015679826" description="C2H2-type domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10202" checksum="A7436522442821BD" modified="2018-07-18" version="1">MLPACWIWSFLSLFLSPSFCTLPLAQCVQPCSYCSHFIHTHTHTSTHFTSLDFTLLTRALTLAAARFCPFHAVAGAAELFYHSFGCFARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRW6</accession>
    <name>A0A2T6ZRW6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1127182</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRW6"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="390"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="517"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU78232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="572" mass="60917" checksum="473F885A349E37AA" modified="2018-07-18" version="1">MFGCALNRGGFGSIHFANLLVSVIAVSGFSLADQIVSPQDNQNLLSRSGLVLQTTDEVQAISVPITQWVGSSGEDSLKDTVRTATLAGNLNLYDSSSNTELNVANFAYIDCDKDNATQTYHNLVWNRGAQGGGIPYAVIFFTTKHDYCKWQGAENLTFPYILTTLERRRATAFQDLLLTTRTPVAVSVFYNESDDGAMPDTKTNAQDNNSNPQNPLGPTPSTSVALIILYSITGVITALFLLIIVTGAIRAHRHPDRYGPRSTARQGRPRQSRAKGLARAVLDTLPIVRFGGGKEEGVKSDVEFQGSAARASDTDELERPTTHIAPSQAIPAEGTLAAAPRSDTPASTASTTAAAGGGGGGGGEEAAQKVEVGVGAGESQTELDVNQVRCPVCQEDFEQGQDLRVLPCRHSFHPDCIDPWLLNIAGSCPLCRIDLRPEDQRQSSEIPPGPDSSHENRHSQGSGSTHHTDNARPGQTREELMEALRQLREENRANGGRHRGHTQGPGLSRLRRFLGRRIGSNRSSTVEENVPAEGGDPPSGAPASAVVPPGGGAAFGGDTNNLSDVGASDRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS14</accession>
    <name>A0A2T6ZS14_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1127125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS14"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="469"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="731" mass="82460" checksum="6B6D21CD67DDC3E8" modified="2018-07-18" version="1">MATNLTATGENVKSEETSAGLEESAPPLLYSAKKQWRTLQTFLKQERRMDPTKAGQDIIELNTLEAQGAKDVDQQGPHPKGGKPAKHPKQQHSKPMGDLPQSKEKSEMPTQDQKKNGNLNPKGESPDKDEKPESLHSLLNPIIDKTLFKGHREQFKAALETYLCKYEGATKTQVWESMTLSNILKKAQAAEEKYKKSSVIRGWLRKFAKELPLLKPWLGLLPATLFPYTNVLMGGLKIMLDAAAKVQDGREKIVKILGEIPGIIGRGQVFAEIYQSSPRVQERSEQLYIVMLDVFEHVLIWLTRKAATNFLGAMFFGELYLKGLERKFSKFRGVAETLREEANPCLHQVVREMNVSLMQGGGMEKLVSANEEIVEYVVKTYDATKIQVEMLTNISKMVAQLSKDSPKSQSYSKMDQATNTTPMTDITFSSDIISWRACKSEYLKAFAIAIRISLQNGYQQSLIDFNLIDWIMNSPQMKTWLTTASGILFIKGNRENMPVSTLSYLAAMMLQEIAESDTPVLHFFCGDNANKSAGPSGLIRSLVVQLLASSLLDPTTAPILQISKDIPDETEALCILFRQLIDQFSYPRLLFIIIDGISHFEDENKLEETCLILQHLQEITQHAIATIKVLIMAPCETKFAELLQGAVGGRDTERMGELDKDSRLEVLHALVYLEHERGQRIGREVSYWNERYSESLPDQERGAAWWEMEEPEDNCRGRLAPKISRRRAISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS21</accession>
    <name>A0A2T6ZS21_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS21"/>
    <dbReference type="OrthoDB" id="5474190at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="24096" checksum="8A42BE673755452E" modified="2018-07-18" version="1">MAEMEDSGGKCQKGKGTLKKEREESLAAAHQETLPSTMRGKRSYQAAIAALDAQTAVKEEKIETLRDKRRKIKEWGDRLDASLAEENSRLTGILERVATALVPTGIGSTPPGQPSDIQLPAELEKNETWFELLQARLETAEEALEKVKGNTVEILRIPQQKLLVFLSIVLYQSIIFPLPSLRHYFTMSSSIYNTYSIKDKGCTELLYWITVYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSI0</accession>
    <name>A0A2T6ZSI0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSI0"/>
    <dbReference type="OrthoDB" id="5339271at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="290" mass="32234" checksum="169615F2BA284628" modified="2018-07-18" version="1">MADLNNSYAYASPRFPVFYDAWVFAMFGNTNSETSVYQKYLRSYSHRQVILDLCTGTGRVVRALGEDYSHKSLEDAIIYGIDHAPAMVQRAQATCTPTHPMQEHKWKVASATNFYEALDDGEKVDLLINSAGSISHLLHRRDVQSFLDQVKKSLRPQTGVALISVLVEMIHGPEEKEGPGGSEDLVQDGMGGLILPCEDDGEGLSGYWHKSATKVTWNEDKTVRTDSFYVELHTGGSGAVAWREDLNWGLAVFDEKAWAEDVESAGLKVVNMIPEGDSYQRFYVLSNLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTB2</accession>
    <name>A0A2T6ZTB2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1083471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTB2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="21436" checksum="9B4EB8018BBFFA93" modified="2018-07-18" version="1">MPWAWKLYLPFLPYPFPLISYVYGFFFFSSFFPFLLPDVMTFSSPKHGRLSGTEEGQTKAMHTLPDQLTLPSFLPPSLPTCAYGLEYLPYLSALASPRHGTQVLAQKSKYHRKKKDVTPRKAREKEKKKAKTTGRSFFSFPFAKVCGAPNHTNLNRGSMKLRVCCWFSRWVGLGWVVGGEIGGKCLCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUJ2</accession>
    <name>A0A2T6ZUJ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1082522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUJ2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="72" mass="7943" checksum="5A89CCAE5031C07D" modified="2018-07-18" version="1">MRSWSPFMTAFYAIPSIPGALGMRSQSPFPTAFYAIQSTHSQKGISIQPFSMALQSSLKGESLWRAFLALTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUQ8</accession>
    <name>A0A2T6ZUQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUQ8"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="410" mass="44627" checksum="B53E3A249B010B58" modified="2018-07-18" version="1">MTPPGFSSMPGGSFLPSIPNSLPAYPRTVPAHAFRHSNQSPSPTFGPTRKRLQRDSGFSAQSPPPFEDAGDSDEDVMRNSLYSDSAYRSTLATSNSRKRGLADDDVDDYEHRPGARGGDGAGDSDRPAKRRIIDVVGSVASRVWEFCKARVPIYGPAPRMTAMEMDRNADEHLYDPGMPSYLTNGTQFGSGLYDNQQLITSSLPRPADAGMGRVNTEDQNYFSSRDLSPNKQVDGGLSSRWVMVSPAPTASTAPQQHNNKPSLSASASSSRTSTPTHPRRLQPSASSKRTSRPIVASSTRKRPTVVRPSHQRSRSSSAVTSSTFAPPPPQSAFTFHSSPISGGASMANTRGRRKGRIPGLATAPSMDDDEDDESMRRFNERLRDMIREGREALGSKVEVVYDEDDDLENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVC1</accession>
    <name>A0A2T6ZVC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Topoisomerase II-associated protein PAT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_979688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVC1"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="772" mass="86939" checksum="2F418AF5FA067100" modified="2018-07-18" version="1">MSFFGFDTSLPRDRGHPAMAPGFSQATDHFAGLSNADDDDDDGIDFEDTYDGLGDKLDEKDDAFNDETFGAPEEAIGKDFDFHGATARVADAMEEEHEVFNRSARNQSVARVAAAPTQPARVEPPTHVPVLRPDMSLWGSGPATTPQPEPQPDPTPVVPPVGRKILSLEEVEAQILANNEQKHQSSFQQPPAQAHQLPPQHQHTPPIVTPQLHQYPPPQHDLHQLQSQQFPARIQSMLQRNQTPPQVQHRQIPEQHPGGVPLQQQRMQPVAQPLHPSRNQYGMTNHVPTPQLQKMTEAEKARFLEEESKRLKRNHKIAQLARYNGLMTPADKNFITRIQLQHLVSINNAEDNANEDFYYIVHSAIRARTNPQQPLNQFAQTYLFRQSARGRNRQQDNHLQRMEQQVQRAVAAAKARPKASQLVLEGSLGKISFSNVKTPRPMLNIKKSDTSGGEPIRRTQRSTFSSADRKSLLRAIENVYDALLELEVHERERAKLPILMPDQQPQQAHVEWSTRRDQLVAKLWKETKIMEPIDPMSTATHPFIAILSYSKMKRAVQRIFRHLDPEQRVTVLTMIVVHLDILDVVKHGVYLPDETQLPSAVREEIEMFAASVLPPLLGYVYEAPLSIVIGLLGILLERVDVVAVSKTKIGLAFLTMFSSRAEIVKQAGGAPENELQQWQMMYDRLFDSLQGHWMECFPPGMFVDDVYVWQFLASIAVGANMPQQQALVSAVKDRVMENVRASKTLPPELGAQKSANVNLFMRAIGLDVELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVJ9</accession>
    <name>A0A2T6ZVJ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVJ9"/>
    <dbReference type="OrthoDB" id="5467127at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015763310" description="SHSP domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18329" checksum="10FF2647F297C29E" modified="2018-07-18" version="1">MPGFLLSQCSTLTIACFLHRAAVAPPDGRDPVCPNTPLIGPSRNYLFPDQFDVAEFYTVPESDSDEEDDVECHARHRRAFPRSHNGWQRRILSNDRRVVKLQTHSQELILRARVKQGPAFMSRYAGQDILIVALPPGIPPPRCEVSVHDAIEEGADDNGGITNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVQ1</accession>
    <name>A0A2T6ZVQ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_813272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZVQ1"/>
    <dbReference type="OrthoDB" id="5406472at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="795"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="855"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="916"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1060"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1204"/>
        </location>
    </feature>
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        <location>
            <begin position="1205"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1228"/>
            <end position="1246"/>
        </location>
    </feature>
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        <location>
            <begin position="1257"/>
            <end position="1274"/>
        </location>
    </feature>
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        <location>
            <begin position="1290"/>
            <end position="1306"/>
        </location>
    </feature>
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        <location>
            <begin position="1307"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1436"/>
            <end position="1480"/>
        </location>
    </feature>
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            <begin position="1511"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1531"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1555"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1592"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1678"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1716"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1806"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1944"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1986"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2054"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2130"/>
            <end position="2146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2149"/>
            <end position="2170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2170" mass="241725" checksum="1AFB79B7FA47AC90" modified="2018-07-18" version="1">MEERSRREEQERVAEYRRRMEMEQEKARVRKLEEERKAVMALQLKREEDGKRIQLERQIAFEREREREREREARAAEEKRRNTVLFEMRKLEEAEFERRMFMQRERSKQLREQALQRAQYEFQRARQAEEEEKRRIQIQIEAEEDLRRKQLVEEEEKRLTEHREKKRMEEEVARQLYAQAEAEKLRVKLQKQQEEERRLNMEEEMTRTLQAQIEAEKVKEDQRKRGEEEEREYKLQVEERKRTIATVEAKRRDAEEFQMIEQEIELERGRKAEEERKRAIAAAEAKRRDAEEFQMIEQEIELERERKAEEEEHKRTIATIEAKRKDAEEFQMIEQEIELERERKAEEERLIQMEVDRRLAAERAERERIDLEAKAAELKAQMAVLAAQQKEARETRRRKRKADPNYGAREVSRNRERSRERETEREKARREQVEMIRKNAGLDEKPSKSKRNVSFAELPMKPVEFVEPSWTVPGGVPKLVQTAPTPPPGTPKTPLLVHVDPSSYFPPTEKEKESESSKEQLGVQESEAQGSEIGSPEVVVASPPPSSPEVGFSILDKDIAIGKPFTGIPVAPQPNNAMKTAETVIAIGIAEESHETEEEQRGRRRNVYYGPMLPENYQFRKTTQQESFYGPELPTDYFSAVPGPSISVAEPVYFDQSPPVAYGPPLPDDYKPLKRSDSGSSEEGRFHSPAEFTEVELKDHSSPPPAYDGAVSGASSMYVVNTAEVSLDNTAEVSRDGSWENLASGAVLESRKGKQAMAEEVVEAIESKGWKNTEVYGESASLSVDRSKSSGVISEDDIIYGPELPEGPTFERSKSETAMSVHEEGRTEVLGSNASYYGSTPEQFLQKVEEAARAEAAEAQKQNIVYGPPLPQDYSFGTSKPAPPAGDRSLYSSDSKASSQTTVTKVAENSGEFRSYSEQSRFEGSSESYTLESGSRSEQVAPELVAYGPPLPDHFVFRVNSQGRSSSQRGEEQPSPLDVSESHTESRHESHSTASVSRDNVYYGPSLPEGFEFKKAISSKRRSRRPGDERPTSYSSESRSESRVTTGDASDTIFGPPLPEVKKKSSRSERRSSRDVSASSSTDSVVYGPALPEDMQLRRTTSERRSRTTFDANVPPPTENQAAASEGHRLRRSQTERVKPQHGVHERPRSYMSDARSSAETLDHRQGAPVPEGRRLRRSNTERAESRRSHEERSGVLSEFKSRPDATTTAVSGATDVQYQTQPIPAMPEERELKRGEHTEVLDERSTFYSSESRSSDATTTFVGSSEGQAQVQTGRGMPPMPDGHRLKRTQTERVDTRHALADERSTSYSSESSSGAAAGSLERRIRLTDTPGAPPVPEGPRLKRSQTERVDIRHPAVDPRSAVIEERATSYSSESRSGGVTASVSGSSEHHQTQSATVPGIPQMPEGQRLKRSQTERVDPRPVAGEAGASYSSESRVESRSGAEGTERGRAFPEGHRLKRSTTERARPTKTRPTADERAPFYSSEARARSDEFIAQMDGAPNITEGFLFQQSTSSSSINSQAHGYDSSRTKSGYSADVTSASESEFATPPTGGTMDNTPTATTRNTPVSRQNAPGSREGSRSVTPRPPSRKSTEEKKQEDREFTAIAMAAAEDAGFNPGLVLSETITATPEATKPPTPVDQRSIEGEDTKGDRSRSLSRLPQVLRSGSRSKSRRQRTGSLFGRSKTSDSMSSDSRADSMTPGSGGVSIESSPPAFERRSTDTPRKMSLTASVISGMKRMGGSGDKSHPQGGPGEVERTPHSTPPASIMDGFLPGRRSRKSSVTYHSDDSQMMEETERLAAGSGTESKKEKKERIEREKKEKREEKEREKREKKEEKERSASEAGSPESGKSRWGGLFGKLGVKQSPSTSPSKPPGFANVVQRAMTEPTKIPSLPTRSGSDEGETHTRPTTSSGKSFRSFAGIFGGGKLDHHATDSASAASVSIHNESLTSQDPGRPSFDASQSDHVEARTATLSGPQEEVSNDGVRLRGFGEVDKGTIETSDQAGIQVGEKKKTGIPLPRGGLRRGRSAEFAGLSGRGSLDERGLPSPIPELLEGRDSWRNSRDLGLSLDQVAGINRADTRTPEQIPLPTPDLADGDQDPETRIPQPSASSGRKGLARKKKTGDLAAASSESIDSLPEQHQSGDVNDTEVRMESRLPQIRRTESLKVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVQ8</accession>
    <name>A0A2T6ZVQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVQ8"/>
    <dbReference type="OrthoDB" id="10324452at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="15802" checksum="BD455F6BA8619EAC" modified="2018-07-18" version="1">MADSSSKIRAPSAKIYDIPAREVWSLLGVNRRAKNEIDRKIRAVWDKYLGDQEDQFSKLPGDLLDRATEELVQELPEIFEKCEGTWFATWAFFNRHKGRFRESARRNPAARAGSPENEPNQIQEEIPDTPEVGTPATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVY7</accession>
    <name>A0A2T6ZVY7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1100697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVY7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVY7"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015369312" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="378"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU79643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="529" mass="56233" checksum="2B770DECD560B01C" modified="2018-07-18" version="1">MWARSLTSAALIASSLLSTVSAADLDPIVTKGSKFFFKSNGTQFFIKGVAYQSSPTNSTSGTFVDPLSDEAGCKRDIPLLQELGTNTIRVYAINTTSDHSACMKMLNDAGIYVVSDLSEPTLSINRNSPEWDDRLYARYTSVVDTLAPYSNVLGFFAGNEVSNEANNTNASPFVKAAVRDMKAYIKKRNYRAIPVGYATNDDQQIRSELADYFDCGNSTDSVDFWGYNIYSWCGKSSYTESGYDQRTKEFQNYNVPSFFAEYGCNVVQPRIFTEVEALYGPQMSPVFSGGIVYMYHQEANDYGLVEIGSDGTATKLTDFNNLKSELAKVTPSSVQSNSYTPTNTAARSCPTADSNWSASTVLPPTPNKDLCSCMVSALSCVAATKVQEKDTGDLFNYICGESKTDCSGITANGTTGEYGAYSMCSPLERVSWAMNAYYTKQKKASDACDFSGNGKTQTAAAATGTCQPLLAEAGGTAGTGTVTSSPNSSGTGTKGAAAGLSVPAFQVGAVKIGAGLLAAALGGAALVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW45</accession>
    <name>A0A2T6ZW45_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_978392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW45"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW45"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="157"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU79711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="342" mass="36651" checksum="685DF1B76E651200" modified="2018-07-18" version="1" fragment="single">PIEYKKVPVPKPAPDKVLIKIKYTGVCHTDLHAWKGWPLRTKQHLIGGHEGAGVVITVGELVEDIKVVDHAGIKWLNGSCGHCEFAGFPCAKNLYSLDGSFQQFTIGKAAHIARIPKGAPSNAIAPILYAEITVYKALKKSNVQAGQTIAIVGGSGGLGSLVVQYAKAMSLRVIAIDTGSEKQEMCLNTLGAVEFVDFAKGDVVANVKSVAGGLGAYTVILFAVSEKSFQQAAEYCTARGTIVCVGLPQNAGVPAEVFSTVIRMITIKGSYVGNRLDTQEAINFFARCLIKAPFKVRMLSELTQVFQLLEECKIAGRYVLNTSVSSINHILGRFSDLTSPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWF2</accession>
    <name>A0A2T6ZWF2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWF2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="31041" checksum="055F7ADD504EB30F" modified="2018-07-18" version="1">MSALTASAAPAPAPGFDHKVDGYDEKGLEHGFHGKGFGGYGGGYGGGYGGGKDGGYGGIKDGGYGGFKDGGYGGGKDGGYGGGYGGIKDGGYGGGYGGFKDGGYGGGYGGGYDGGKGREKKKEFKDVEKKDSKFHKNKFAKEAAAAEEELFKKQAERDEEEESRKFEESAEQKSKEVCDEERCFEEGFGFDKAIKYDKAYGYCRDINKKFREDEFKKDRQAAKKDWFHCEEEEAHEKCEEAAAAEVCEKCDDEEKKKKEFKEKEKIEKERKEREKKKGHYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX40</accession>
    <name>A0A2T6ZX40_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B9Z19DRAFT_976164</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX40"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX40"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="21">
        <location>
            <begin position="73"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="21">
        <location>
            <begin position="412"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PUU80061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="622" mass="70934" checksum="AC02AFDE7D7DAC11" modified="2018-07-18" version="1">MFSNVFSRGFQVRSVTSASLRHRPIPQSAKAVSAVAKLSSTGSTRQNMAPPTAYQEDPSVGPMLRFQKFLPKLPVPTLQETADRYIKSLKPLLTSQELQRTKTVVAEFIREGGVGQQLQEKLLAKAQNPEVPNWLSDWWNNAAYLAYRDPVVPYVSYFYSYKDDKKRRNPVKRAAAITTSVLKFKKMVDEKTLEPEYMRNLPICMDSYKWMFNVCRIPEKPADYPVKYDYESNKHFVVARKNKFYKVLHEVDGVQLSTKELEAQFARVLELADAESVPAVGALTSENRDTWTEVRKMMIEASPENKKALQLIESASFIVCLDNTSPVTLEERAHQYWHGDGQNRFFDKPLQFIINENGTAGFMGEHSMMDGTPTYRLNNYLNEQIFNDRIDFAAKDVRSNLPEPMPINFELAYLGYGKGLIKKFKCSPDAYVQMIIQLAYYKMYGKNRPTYESAATRKFQEGRTETCRTVSEESVAWCKSMMDPDVDPRTCISNLRSAINAHVAYITAASEGKGVDRHLFGLRKLLPPGAALPEIYADPAYGYSSSWFLSTSQISSEYFNGYGWSQVIDQGYGIAYMINENNLQFNIVSKKQGCERMQFYLTDAANDMRELMESELEAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX94</accession>
    <name>A0A2T6ZX94_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX94"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX94"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="777" mass="86513" checksum="36DC657E9C880173" modified="2018-07-18" version="1">MPTDVLKSGPGNSDPLQESEEDLREYVKIIQLRDKIRDGMHPRFKPANHPGSAQATTPQLLQRGPSASSHGAQLSQAPGLQAPQCTDPKANNARLAKSSALVKAELKLKREKIEKELQKRKLEVEAKIWTGAEPVEHINLWDSSTDVFSDQLESIMKKAGVSFKETIRSVDSAPSKPIAESDENSETATRSGNPEAHQDRHMSRKTWSGPVESTLPTVVEASRRPPKESFASRQLNSDKGTSTAEESTSQRLAIGAAYEPSKAQVPAMPSPQGANAPLDVNNDGYEPAPAEERPYSPPASPRYSATSHLKSPAAPQPVRPANMARVESQDPRGIVEIADDGDEISYSRYAGNPDRELRRDNVSPISPIPLIKQEPRSPFPGVHPSRLPRVAGPAGTYDERQHHSYPPVPPPPPRYGYQPTAHSHPPAAGHPVYDSFGYPLPPPPPPPPPMSGYTRYPPYDPEYYTPRPYEEYNRKYAAPSVVPSRLPTRSGRRSASPVNYPQRSPRSVSPPRVRNPKDSRPASRAEYRPPSRMTRPPSPHRLDMYGRPYPPPQPPMYRPEYPGDYSSYYGPPRERPASYYDPYYRPMRFDEYPPRPESSVIPRGLDDRSYRTRDYPYVPARPSMPPPPQSVAGGYAPDHRPEYPSASRASVRPEDHMERRLEYRPEAGRVSPRREDRPYYNGMDGYFHGREASVRHGSVRPEQARAYGDGEYVPGRQASVRPDAGFRDRFADPGPREPGHMQLPLLNPPYAHPPPPPPPPPPFGGSGYNEGRYGGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXW4</accession>
    <name>A0A2T6ZXW4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rapamycin-insensitive companion of mTOR, N-term-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_975497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZXW4"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="5">
        <location>
            <begin position="229"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="4">
        <location>
            <begin position="671"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1299" mass="144964" checksum="527B3911F71D6F84" modified="2018-07-18" version="1">MSNALTTSPKSVSGASSPGPRSRGASGGDRDGLLHPRQPNGNRVGSSFGGNGSTTIGNSTLSGPGSFSTSLRSTNTIVAMTPNAFVEEISDPPSPMSSERLVEELTDQLNKAIKYKEGAENLLQVLDTKKPKETKQARNQAEKEYNARNQEISQLMNRIEAITKPREVPGVTRAANKFKGEPIRPESANNGLAISGAPEWDPGSESPTLLLTELLKDLEEVDRRPEYYVEKANSLVALFKRHPNLKYELAWNTFGNRVQNMLLNENKEVVAAGYRIARYGMTDLQSLKTIRALYTDEITIISLVKDSRANVEREQALKFVRAFIEVPGGVQEISRGVVRAIVACAEQVDDRLRGVSMETLAEILILNPSLVVSAGGVRVLTQILSEGPYELSDTISLAFLYLLDLPATRKYIRPGSDLEVVFSVFTDSYSEKSPAPEERLRSSAKVISCMLKSWPGLLALSMYGLRAPKSLVSALSIPSSSVRDIILELFFDIFRIKPPSWSSSFLAGRRLTTYGRVTNLKSESDAPKPPRADDAYQGNLVEHFTALLLAVFFEADLLRSLMALVEDNSDPAIVRKTTLLLGEILKLASRLLPSTYSARLQLLPELFMSAANFGVPTRFAASAAVYQIDSLNRTLHRSLAATQAPQRVSVDDEKRGQRQVEQAKLKIYMAIDDRHFSGLIVDSGVLNAKSHTKWNWDALNEMIQGPLLNPKRLDEAIKGTKFMKRLMSFYRPFKYKFSDVKNTKPNQRYVRIGCALFHTLLQTPEGVRYLSENKILRQIAECLAQLDRMSGITSPEPLFSTSRLIGTLSCGYFSMLGVLSSDPKGLAMMERWRMFNMFYHISDSPDRPDLLELFVSNMDFTLEGHPRIILSKALTMGLKSVRLFATSHLRGLISTVQSSQIPIDPKTNETAEWAIRLLITQLYDPDVEVCETAVKILEEACNITHSLEYVVKCRPALDHLGEIGAPLLLRFLSTSVGYHYLNELDYINREMDDWFHGRNDSYVLTVEASLARAFADEEPVKKRPGDINTIDRDMMGIVPPHFYRELARTSEGCILLREKGHFDDFSWYIREHGQEEEDAEIVTKVKGCLWAVGNIGSMPFGAPFLEEADIVESIVKIAEESQVLTLKGTAFFVLGLISRTMQGLEILLEYGWDGTTSTMGESLGFCIPLKLGHLLSVAPWYHTGDETNQVNRPSPLSSVIGDDPVDAKILTAIANLNNHILESGSTKELNRLKASHVTQFQSPDLFRRVMTLIESFRYRQHVRRYILDLFEKSVVERVFAEGRADSEVESPYTPEGVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY66</accession>
    <name>A0A2T6ZY66_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1123695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY66"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12737" checksum="08BA08F91C968ECB" modified="2018-07-18" version="1">MTQQPVHCETATLISATAHILGFSPSGISRFGVLTQYNKDGTDVFMIIIRGAYGGQIMRLDIDWNYSRKILISQWNMHSTDGRSMALNLYQQSGRHLVYTKFALLLGQPPVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYD7</accession>
    <name>A0A2T6ZYD7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000063">
        <property type="protein sequence ID" value="PUU80484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYD7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="343" mass="35843" checksum="5827FB089888AA92" modified="2018-07-18" version="1">MFQKTPNLAPKQTSGGVRPDTGGPSRASGGPSQQRSRPGSPARRSVSPQKRVHDEGEVDRKGKKKQRGEDALGRDITPHTSMEEGSFICPVPVSGSPCCAEMVTFLGLKAHIRSKHLQNLGCHIGDCAFTTRNTDELHQHQMDAHKGQELGVSLFRTMGPGEFEELEAFQDAKTMDQIHQLFAKQGGGPSAPGPSGSGGTGGSGGGDLGEDNGEGRQDDDGKGDSEGDSEGDGEGHGEGHGEGHGEGHGEGHGEGHGEGHGEGHGEGHGEGHGEGDGEGDGGDLVPWEAAEGIIESGLAAFAQACTDNLRRQYGTAPRPRAEMEEVVQDLRRFFTALAARDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZI4</accession>
    <name>A0A2T6ZZI4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1100058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZI4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZI4"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="283"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="436" mass="48043" checksum="5F84DD86C9AE2A27" modified="2018-07-18" version="1">MAENYEDICHLGDLRGPTSLRGYDPELPFATESANRGPAQLAPGQDKDDPEGRILNFQNITEPQPLRGTRGGTIASNHNTDLEKLYPDTFAPPTTDHGSVKQAEWPLGLSHVKLGLDRAGWSRQQNINVLPAAKEMAGVNMRLEAGGYQWALMLNGSARIQAMNVDGQTFIDDVTKGDVWFFPSGIPHSIQGLENGTEFLLVFDDGEFSEDSTFLVSETFALNPKEVLTKNFQLPESAFENIPEGELFIFPGTQAPEDIEKQNVTGPAGIIPNKDSYSYHWSLQKPIIAPGGTVKILDSNTFPIAENFAAALVTIKPGAIREIHWHPDSDEWSYFLSGTARLTIYAAQGNARTFDFRTGDVGYIPKSQTHYIENTGTEDVIVLEVLQAKRFTDFSVGQWLALTPPQVVQDTLHLSDESISKLSKEKPFVVDGPIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZV7</accession>
    <name>A0A2T6ZZV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZV7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="18453" checksum="081DDC22817F72F2" modified="2018-07-18" version="1">MKRRKMTTRHLIMVTATAIDFGDPFHSFILGFHQGFLYLIWAWFSSVFWHHTTITTTRRLLVSSSLSCLTSTSRNYWTWLWRCGLAGYSRFGGVYGIVITLLGVQQQKINKEVRLFVWLLVCQIFINLSYHEWTSLGGNQAIFLAFSLRNGAKKWHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Z9</accession>
    <name>A0A2T7A0Z9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylglucosaminyl transferase component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1019719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Z9"/>
    <dbReference type="STRING" id="42251.A0A2T7A0Z9"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="766" mass="88085" checksum="F5B17206B8692C37" modified="2018-07-18" version="1">MRPLVLTIVVFIAGYITARFSLITQAIDLSYFAWDHGVLGRATKGFLILSLFFFLFFLPIERIASREISLGEFLLMGSNGLMRVFWPLDFQRSSQPGVLVGWRNSELDIFVVDILNGVDSRRVAKELSSRSLYRKSLHSVERIFELCGRTELHVLGSVNEEPGPLFQPDHIYAFTDKSCRYPQIFCPPASGIDFQVILFQRPHPRRMQYLSLTPISLALEDRMTNGSIGDGDDTIEEQRERERKAELVEKLKLHSVVRPTPTMKEKGLQMIIDQINCSHEMRQLLKENVGLIMSRRSRRSLSVSERVVESATSLWRIVLKGLMDTAKFLWPFATKLFVLIILVWRLVAETILRVLEWRLRPELAALKDISATAQQFDIRLQQFCYWPIQYVTLRRRKADWESVTTSHPDYIRFYNSLWLVANDVIIGIALGSYIIENAGGVAYQIDYYLRSYTVEGMKAMIYWLTKRPGGLKLNDDLGDFLGDLFIWVIDYWADTMTNIRPHLPGVIYAIGFSSFAGASMPIALFSDLLSILTLHVYSFYIASARIYNWQLTIIISLFHLFRGKKRNVLRNRIDSCDYDLDQLLIGTILFTLLIFLLPTVLVFYLTFASARMAIIMLKATLETLLACLNHFPLFALMLRIKDSKRLPGGIRFELLDTVAVVKGFKRSYEIPPLSYINLKSTPLPFGAMFHQYFQLGQRIRKHYVSPHVIICLMTGRFVPPIHRKNLYSMQYSMLPTKRAGMLELWIRLTEDQPGNGAVPANGRTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1B6</accession>
    <name>A0A2T7A1B6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1B6"/>
    <dbReference type="STRING" id="42251.A0A2T7A1B6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8639" checksum="BA172B2E3BD3E9C6" modified="2018-07-18" version="1">MDLYKRVTRKDSRPFNTDLVLRGIQEGIRHLHSLGLVHCDIKPANIVMNHGDTPVIVDFDSCRHKGEKLGLKGGTCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A203</accession>
    <name>A0A2T7A203_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000040">
        <property type="protein sequence ID" value="PUU81763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A203"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="125" mass="14075" checksum="744E77B9B3F916F8" modified="2018-07-18" version="1">MSSPPRIDHTQNHSLHVTPQIPSSTPNPTTPNNCDRKELSSTEPDTLEESLSEIPLLDQQPSLIPTPQEWKRRRANEAASTLLNLPDDTPLAQSIGWPSRNPNRVPGWWAHLSQYQALDPRLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A208</accession>
    <name>A0A2T7A208_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A208"/>
    <dbReference type="OrthoDB" id="5423525at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="20630" checksum="6F5057E6345247A8" modified="2018-07-18" version="1">MYDCRTQGGHFFVCQSTHPTLQCHHCSKTMSRSYRCILEKCGYLACESCSTSINASLDEFHKSRELAKASGLPLPSPPSCHSPTPAPALTRDVDDDRDDGAVGRPRRGTVESVVGAISSTSLGGPGASGDGDAALGVGIIEVDDDVQDEDYAPPKRPFTRSAAMAAAFAATRHLSSRARTQSSVFRPRAGEGEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A226</accession>
    <name>A0A2T7A226_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1062360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A226"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="11509" checksum="366E11FD961A33D5" modified="2018-07-18" version="1">MVDEACSDICAGFGNTDTQFGKVSQEFENVKKLLAKVNLDFGTVEELFLGIRQEFGNVQTQFTLINERLDLVEAQLQHMVVFLGDVEACLVQVADPVDVPMGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2C8</accession>
    <name>A0A2T7A2C8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2C8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11413" checksum="1650D5F4F7A2208C" modified="2018-07-18" version="1">MTDFKQDSYGNLNTRIGTDNEDILNEWALASVPDLQAASSWGESTSTSSEEQETWGKLEDEMASETPIILAPPTSKTKVFEALMIIQYPPALLLFLKGEIFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2N3</accession>
    <name>A0A2T7A2N3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_969807</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU82007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2N3"/>
    <dbReference type="STRING" id="42251.A0A2T7A2N3"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056998">
        <property type="entry name" value="Asd-4/GZF3_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF338">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25026">
        <property type="entry name" value="Asd-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="11">
        <location>
            <begin position="4"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="176"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU82007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="272" mass="29787" checksum="B9A631468038D891" modified="2018-07-18" version="1" fragment="single">QPICQNCTTSTTPLWRRDESGSVLCNACGLFLKLHGRARPISLKTDVIKSRNRVKNSGQPAKKKVNLQSLFDSPNGSANNHSAARSENGTPPPGHRKPSSGTASNRSASPQSRAGTPLPPPSHMAPSIFESLVNQTENSMVGSPSTLPALNTLNHPSPGSTSSLHDRHLENPAPTLDSLISANNKLKTRVAELELVNDLFRGRVNELETSEANARRAEITRREVEAQLRLCLDASTKREEDLKRKLDDAERELTDLRGDQQRKKVRVSDLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2S1</accession>
    <name>A0A2T7A2S1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1075930</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2S1"/>
    <dbReference type="STRING" id="42251.A0A2T7A2S1"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="131"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU81985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="978" mass="108315" checksum="DA4DC7D342F1B0C9" modified="2018-07-18" version="1">MDDLYDEFGNFIGEAVDSDEEEQRDDNGADAYVGYEEEASAAGEDAQQLMELDDEGPSNAVVLHEDKQYYPTAEQTYGADVETLVQEEDAQPLSEPIIAPIKVKKFTVEEADLPKTHFSREFMMDLMGFPDQARNVALVGHLHHGKTAFMDMLVVETHDLEGNTEGKKGEQLRYTDTHIVERERGVSIKSSPMSLILQSSKGKSHLVNIIDTPGHVNFVDEVACSMRVADGIVLVVDVVEGVMVNTEQIIKYAVNENIPMTLVLNKVDRLILELKLPPTDAYFKLKHTIEEVNTVIENAAPGRGESMRLSPEKGNICFASASMGWCFSLASFAKMYADTYSGINIAEFAKRLWGNIFYNPGTRKFTRKSMETKSRRSFVHFILEPLYKLYSHTIGESTGSLKSTLAGLGISLKPAQYKMDAKVLLKLVCGQFFGTATGFVDMLVEHVPSALDGAKAKVENTYTGPLDTELAESMQNCDPDGPLVIQITKLYHTSNASDFLSFGRVMSGTVKPGMQVRVLGEGYTLDDEEDMVAATVSDCWIAETRYKVPTSGVPAGCWVLLGGIENSIVKSATVVAHKMDDDAYIFRPIKHFTESVFKVAVEPVNPSELPKMLDGLRKINKSYPLISTKVEESGEHVILGTGELYMDCVLHDLRRIFSEMELKVSDPVTRFCETVVETSAIKCYAQTPNKKNKITMVAEPLDTGIAEDIESGKVSIKWPIRKVGKFFEENYGWDLLASRSVWAFGPDERGPNILQDDTLPSEVDKKLLNQVRDSIRQGFSWGTREGPLCEEPIRNTKFKIMDATLAPEAIYRGGGQIIPTARRACYSSFLMASPRLMEPMYSCSMTGPADSVSALYTVLAKRRGHVLSDGPIAGTPLYLVKGLIPVIDSFGFETDVRIHTQGMAFCSLVFDRWSIVPGDPLDKEVKLRPLEPASAQAMARDLTLKTRRRKGLSEDVTIAKFLEPELHAMIESSGLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2X3</accession>
    <name>A0A2T7A2X3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1041777</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2X3"/>
    <dbReference type="STRING" id="42251.A0A2T7A2X3"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="525" mass="57513" checksum="E34AAFDB5067989C" modified="2018-07-18" version="1">MAAPVTRMPLARLPALPAASTPEKRYWGTFKSHLLIQEYGAIKSINFSPVSPHDFAVTAATLVKVYSSKTRAVSKTISRFQAPAQSGSFRSDGRVLVAGDDSGLIQVFDIGSRAVIKTWDEHTGNTVNVTKFSPTNVTQLLSASDDKTVRLWDLTSSKSTHKFVGNQDYVRAASFVPGSPYSVVSGGYDRAVRLWDSRSATNHCTMEFNVPAPIDALLVLPGGTTLLASSGPTVYVWDMVAAKRVAVLHNHQKSVTSLALSTGPHKSQRRVLTGALDRHVKVYDPATWKVVHGVKYPAPILAIGISPDEKHLVVGMSNGLLSVRTRSSGKEKEKAKEKERVLDMIAAGIDPITGIGGPKSKTSAQRRRTRGMDYKGEGADIVVEQVARKKKEGPWEHHLRKGNYGDALDFALMSSQPHVTVFTVFGELRYRNAINAALANRDENTLKPILRWLIKHLPDPQYVSTIVEVSLSILDMYSHDLGKSPDFDKLMRRLHLRVKQEVENSKQSSLIVGMLDMLLAGSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2X4</accession>
    <name>A0A2T7A2X4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_969502</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2X4"/>
    <dbReference type="STRING" id="42251.A0A2T7A2X4"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000053">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="11">
        <location>
            <begin position="36"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="10">
        <location>
            <begin position="182"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU82060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="452" mass="51421" checksum="144867460C6DBB32" modified="2018-07-18" version="1">MTSDFFYPQPGGVESHIYQLATKLRDRGHKVIIITHSYQTRHGVRYLTNGLKVYYVPFFVIYRESTFPTVFSFFPIFRNIIIRENIEIVHGHASMSSLCHEAILHARTMGLRTCFTDHSLFGFSDAGSILANKLLKFTLSDVDHVICVSHTCKENTVLRAALDPSMVSVIPNAVVAENFKPDPNAASKTHITIVVISRLFYNKGTDLLVAAIPRICELHPSVHFIIAGSGPKAIDLEQMLEKHMLQDRVSMLGPVRHEEVRDVMVRGHIYLHPSLTEAFGTVLVEAASCGLYVVCTRVGGIPEVLPSHMTVFARPEEDDLVNATSRAIKEIRMGRVRTDKFHEQVKSMYSWTDVAERTERVYEGICRGERVGLMERLKRYYGCGVWAGKLFVLCVVVDYLIWVLLEFLFPRSNIDIARGWPRKATRIGEGSTRRDRSRRREEVLVEEENVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Y1</accession>
    <name>A0A2T7A3Y1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1041022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Y1"/>
    <dbReference type="OrthoDB" id="5405951at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015438595" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="28703" checksum="1215AF1E6E878554" modified="2018-07-18" version="1">MIDLEFKFAGSILCLVGLISSLTSGAGVALQPRDADVDFSKMPDCSSKICVSILGSLLDCGGEITLGCFCRRPNPLVCAWSVNWDCWNRTEDWYDSQCPGKPLVDLTGIPECARNCFNKANVCIEQTSNCVCSQPKPDCSFSTTTCKAADVSLYDAWYTKSCKYNLTATTSPSTTGPSLNPTSSTSTSPTSTGSGGRKGLPKGAIAGVAIAAVAGALALGLLLYYCRGRGASSSDSAAVAPPDQYKIEDPSGLVARPGPVPSMVQSTPFFEAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4H7</accession>
    <name>A0A2T7A4H7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1061675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4H7"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="29834" checksum="CEE2734277125CAF" modified="2018-07-18" version="1">MQFPTTITSPVDGTIQADQGCPSQTSITACLERDEFRCLITGCKLSGSLGREVLPLIPFAFARHPRCRGLDFWKMLEIFYGADAIDKVFAGLLNQADSLHNLITLDTSIHTIFNGGSLILTPVTASGDPIPVINDHSGGYMLNIDYHGLSVLEFIQSTKDLTPGTVRTLYPWSKIAIASHNPMPANDSASILPLPTYFALRAFVLSLKNICAERPPQLDALSFSGSSFTPSPHPPIDLKNENPTYPADSESLCDDPVLAASAILQSMVDAGALCQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A534</accession>
    <name>A0A2T7A534_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1074017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A534"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="15570" checksum="805D7C76F50604B9" modified="2018-07-18" version="1">MRTAPLGCQVSMITLGGVLIGAAGALVIVLLVASAVWAWIRRRHDATTADATDAEEGDRLLRFGREGLGRRVSFWAYNTFLPDNGGGGGGGGTDAAAGGYGTIGGAGGAGTGGYDGSDGGRGGGGVIGRVDSAQSFGSGGLDDGLEERRRKVLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5L7</accession>
    <name>A0A2T7A5L7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1112606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5L7"/>
    <dbReference type="STRING" id="42251.A0A2T7A5L7"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU83029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="340" mass="37152" checksum="3415E8DD12B79D41" modified="2018-07-18" version="1">MDDYDTIYGSDRGPQITIKEADSRHAQIVLSNCDLAFANALRRIMLAEIPTIAIDIVEIQTNTSVIPDEFLCHRLGMVPLDSTNIDDKLIYTRDCFCDQYCERCSVTLSLHARCTGEDNVTVYARDLVIAEGAQLGSPVINDPEGQGTIICKLRKGQELRLKCIAKKGIAKEHAKWAPTAAVGFEYDPWNKLRHIDYWYEEDAKEEWPKSKYADWEEPPIEGEPFNYDAVPSRFYLDIESAGSLPPDEILQQGIKYLQEKLAAVIETFSNKNEAGDGFGDGVRSPGQDYAMGGMGGGGAGYETPYQGGRTPFGGAGLAAPPSTGGQLMGGHKCVAAVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5R3</accession>
    <name>A0A2T7A5R3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1061233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5R3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="23877" checksum="911798705FC17ACA" modified="2018-07-18" version="1">MANDRSAYMAISMIPGNTDMVLVAQLPTQLAKKLCLISRYFMPDACEEISERARLFSIPCFSHTKSLVLLFSSLQLPVTARVFVHFRKWPGFGASWVLRSLRASKQQGRTHPPIHGIGIWKEFETSRLTRGVLDKACLKAFFFLSSRNRYQGLTGPDPAKPAETRDPPTKYWLPRFQIDGFIVGTGESRARARGALPAGYGWVCTPQSHLDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5R9</accession>
    <name>A0A2T7A5R9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1073637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5R9"/>
    <dbReference type="STRING" id="42251.A0A2T7A5R9"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="9">
        <location>
            <begin position="89"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU83015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="454" mass="50231" checksum="D64EAFA97DFA8656" modified="2018-07-18" version="1">MFAFRSWSAATHVRTIRRPLAVCSVLPRSGFSAAALLRQEVAEETSTSNPDVEAADTDADPEPRIPLSIQSVWYRPFRRKAEYGLPVCDLQIRSYSVRNLEFMCDFALRAAYYLNLPASGPVPLPRKTERWTVPRGHFVHKKSQENFERVTYKRLIQIKDGHPETVEIWLAYLKKHQFYGTGMKANVWGFEELGVGKRMNVSLDNLRDVATKPKWAHSGVGKTLETAERAAEILNSPEYRALADKTDLDEAKRELLQAVPLGTVGGLEEASEAELDEAIQKVEEEAMKAEESKEEAEINAVDQIVDEAAELGEEPIELDGLSDTAATPSLVVEEESKDVSDVPAEELFPTPIETASPVSESQPLAMEEAKEISEATSAQDSLAGPSETAPPAREEEPRPEAVSQDNTTQTTPEVIEAQKAEAEVETEVKKVVEETAVDGTTREDAGEPKQEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A620</accession>
    <name>A0A2T7A620_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MRC1-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1189800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A620"/>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="6">
        <location>
            <begin position="970"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="599"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="839"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1279"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="160"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
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            <begin position="228"/>
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        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
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            <begin position="345"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="599"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="614"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="680"/>
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        <location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="741"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="839"/>
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        </location>
    </feature>
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        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="924"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="934"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1283"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1329"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1370" mass="150740" checksum="5294F9E43F8632D2" modified="2018-07-18" version="1">MASLESPTAMSVVVSPPGTPSRDGSASPVLTPKSKVEAMLAEMEPTDEESGGSDGTADEDSEIELDYKPRGKLASRMMPRASDIKATKSTKTLPTIKNNTTGNGDAYERVKRSLLAGRETTSKILISDEESGNEEDKSASSSKALVQTDDDDDDLPVPTPRRKRTQKAHPKASPKANSTPSTEFPKQKGPSQSKSTTPVSASESEGGDEGDVHNLLATDPKKNARFLELVEKKRKERQAAEAEKQRLEEKRKQLDAQLGCGSETDDGEDDDDLGVLSQKPPRRRSGKKALEEMHRESQRMARNMHLEYQARTKKTITKQSLFEKFGFRAPAEKQNENKKDRVPVDSSSIITGSETEPADQSSPNSSPLPEANEKSAKIATGAMDIDNQGPSISEGPMQRESDRMGIDSTSAPKLDKGKGKARAVSEGFDEGETAHPALALDKGKGKTIEIRSSALDKGKGKASIMSSKKTKLVLPPIRVILPNKLTENASDSDSELEIVKPGDEERIANSERKKMVDQLRRVRRVKPPVEVHGKPKLSVRELEAELRKKSRQQAIQEREERIEELRAKGVIILTAEEKAKTEQQAVDYMEKARKEALAIKRREKKDGIKKEGATIDDMDPNEDDEADGDWLEEEDIVEILSGSEEEEEEEEGEEEEESAEPNDLIDEDENELMGGLGSPAFSSLYPQDNDLLSPTPRLSEMPAAYIDEEADEDSDESNGDFAPFKTLKRKAIRKKKLRVVEEDEDGENEDDAIESEEQKIAESRIPSIFRNKIAGPPPVGMTQLFNGLSGLPPSAEVSASPGKVRERLETLRQDLGEGIPNSQVPLDFGDDRLDLGFVKKKDGEDSKPIDEPSFPVLDLYYEPSTQMSSFPDPTQDDGFVKSSSPAPPRFDEDELSTIEVPDSQPPKRKRGRLVKKGADLTAVMEEDENEKESDDERKSEEVEEKKESAFDVMRKAAKKEKAAENFDKAKSGAREMVHEQAEESEDEYAGIGGASDDEAGDGHDSDVEEMIDDEGKEVVDEDDIAAFWAEQDKAQDEKDVSKLFRDLQTGLFRKKRGADFGLGDSDDDDGEARRRAKRRQMAKIRKALMADGNIEKLATNPKKLAFLNAIEDRDRDDEMDFLDKGEEDLFIDLGLLEDSQSQNPSQSHDSREASTVAGAGASRGGTPGSQHSVGESNEIPIITNTRRTTRPKKPSLADVRETLSFLIEENDSEMIELSDSDGEPAEAFMHKRRRTATTVVIDRVAASRSNSAMSESAKLAFQSATETQFRVPSLLRRATTNMSSSTSGDSQGSSGASSTTSGSGGKPMESSTTGGIKRGGKASSSINFHQREQVRAKVENERELKRKQERKRQGQERQGVLGMLTKGSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A667</accession>
    <name>A0A2T7A667_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_965256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A667"/>
    <dbReference type="STRING" id="42251.A0A2T7A667"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="498" mass="54872" checksum="7D0BA737C496EDCE" modified="2018-07-18" version="1" fragment="single">PQSSIMPPPPTANPNDTIPDAEAILTTYLRTLPPSTNFTTEDQSLLRSFLDALYNNPKSNPDTPVPVPTLLTTSTPKSYHAGTGKTQTRALAHAIERAKQEVIFVTCFWAPSESRTLLSAALRELSTRALARNVKVRVRLCFSSMSVWQRAVSPPRGKVWEGLEDLGLPGRGELPGLDILVKSLFFPPFSVLHGKYCVVDRKLVWIGSGNVSWECWGEGCGSFEGEGFVRSVLEYYRVIWEEGCLELPALPFLEEEGMEEHEVEEAGEGEKGPDVLDEIREYPTILLPNPHHRNPHFSLRSSIQSLTSHLPCLRARQSPSLLQSPPPPNTPQNTFLLTLFSHAKTSITIHTPNLTSKPLLSALLSAASRNVHITIITCRNMMRMEQLATTPFSTTESCVDTFISSLPDLETGSGKVHLGFWRGRGEVKQWHVKASIVDDAWTVIGSANGDRASWWGSGEINVCVFGGGYAREVGGRLERWAVEAGGVEWILGGRELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A676</accession>
    <name>A0A2T7A676_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_189791</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A676"/>
    <dbReference type="STRING" id="42251.A0A2T7A676"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000002">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="205"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="501"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="867"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1048"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU83220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1142" mass="130750" checksum="1370E71FAFB97B34" modified="2018-07-18" version="1">MVKARKSRVVSDSEMVDEIAAKTVKHNKYETDDNADISMNDADNGNDGGDEDDEDQPDKDGSDGDDDTSIEGPADGRRRRKAATNKQKRAFGRKNDTLNKTKENDSMKRIRYLLGLTDLFRHFMSNNPDYQRVKAEEEEKSRQLAKNRKGSTDNRRRRTEKEEDEELLQDEIVDGGTTAIFTESPKFIKGGQMRDYQIAGLNWLISLHENGISGILADEMGLGKTLQTISFLGYLRYVAGIKGPHLITVPKSTLDNWKREFEKWTPDVKVIVLQGTKEERQKLIQERVLMDDFDCLITSYEMILREKTHLKKFAWEYIIVDEAHRIKNEESALAQIIRLFNSRNRLLITGTPLQNNLHELWALLNFLLPDVFGDSAAFDEWFENQGGDQDVVVQQLHKVLRPFLLRRVKSDVEKSLLPKKEVNVYIGMSDMQIKWYQKILEKDIDAVNGAGGKRESKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHIIDNSGKMVMLDKLLKRMRAQNSRVLIFSQMSRQLDILEDYCVFRDYQYCRIDGSTAHEDRITAIDEYNKPGSEKFIFLLTTRAGGLGINLTTADIVVLYDSDWNPQADLQAMDRAHRIGQTKQVMVFRFVTENAIEEKVLERAAQKLRLDQLVIQQGRSQQQAKAAANKDELLSMIQHGADLVFKGGKEKEANISQNMTEDDIDAILKRGEERTAELNARYAKLGLDDLQKFTSDSAYEWNGENFAAIKKPSIGANWINPAKRERKEQSYGIDNYYRTVLTSGNKAADTKPKAPRAPKQVNVLEHQFYPPRLVELQDRETAYFRKQQGYKVPLPDGEADDLEDRQAIRDQEQEGIDNAEPLTEEEQAEKAHLAEQGFSSWSRKDFGTFVTLSAKYGRKNFAMIAQEMETKDEKDVRKYAKAFWERYKEMPNWEKFINTIETGEEKSAKISQQKKMLRKKMEMYRVPLQQLKLSYSVSTTNKKVYTEEEDRFLLVQLDKFGLDAENLHEKIRDEIRESPTFRFDWFFLSRTSLEISRRCTTLISTVAREFEENGTSVATTKATVTKKSRDREEEEEEEGPPAKKGKANSGTAKETNGKAAKQPPKNKQVEQAKKGGDSKATSNATSRASSVDSKASAATSVSKSKSRSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6G0</accession>
    <name>A0A2T7A6G0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase I associated factor, A49-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1073034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6G0"/>
    <dbReference type="STRING" id="42251.A0A2T7A6G0"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="434" mass="49440" checksum="4E49F2B6659AAAD2" modified="2018-07-18" version="1">MPAETKRKRDPSSEANGPLPDYTITIAPTNDFPPILASSHGISIPPTTQFTPYIHTINPPSKKSRKAEEFLLYGETPSIGYEGREMPEDAEYRRHYVGIFNPKTNGIELHAAPKLHFGRMIKAHIKRDRLVDGKGVVMSNVDSRTALGKEFGTKKSQKRLRELELNKIDVSDMGKNITTSIVSQVEANTKDMPTAVELGNQIRANKPIPKVNHDANHPDEVYNLEDIISSDEYNVIWVREWERGEELKSKSSFVQARIRKLAEDKSKKHTRLLKILRYISLMIDFYLFQQRGRGRLPAMDRVKKALSVDHAIAEGFFRRYTEKNVSSEEGSDKDIYAVSPALANKILYHMAVLCLMVDHYDVDIFQLKNDLGVQPKELTLAFKEVGCSIRELTKPQYTAMKMTKAEAMQHKRAVLKIPLEFPKPPSRRAKATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6N0</accession>
    <name>A0A2T7A6N0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1061059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000014">
        <property type="protein sequence ID" value="PUU83368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6N0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="20853" checksum="1EC0459C89DF8166" modified="2018-07-18" version="1">MPQNSYAGMSRSCSATYVFCSENGKVIHQNLTSSPNFSQPLHYTTLNLRQPTLACPVSGCSLVFKGEIAHGYLWRHLKRPGLSGRTGTEKIDWLNLHKVEHDRLLATRITPAQRKHGARKAKAQKLLRAADFELRARNMGIMEKSLIVQKVVIWEGMYEAEQSGDSIGWVHSHLFTAKEQYTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6W1</accession>
    <name>A0A2T7A6W1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1098608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6W1"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="222" mass="24803" checksum="7CF6155E15934B61" modified="2018-07-18" version="1">MKMPTTSKDVQSERITNSLRLFNYHARDCPSCCDPYSVHLSKTLLLCDHGHALAQEAAEALYAKARTTPMGQIEVTFPEGWEPVDGLIKSITHQLQGAPSNRIDLTAMKNAKTASNKTSRRIEAERDGKIEYVSAGGRGSSFARDLSRRGIEGTPVTVVNRSRSRYNQYVDPNRSSGFDLAAPVYEQPQQQYVYHGRRAEPHSPRTSGKGVTFNPEVQMRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Z5</accession>
    <name>A0A2T7A6Z5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1060983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="9">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="826"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1209"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1286"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="845"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="871"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1294"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1328"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU83511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1356" mass="149031" checksum="E522112CCC22997B" modified="2018-07-18" version="1">MASTKNSSIGVKLVWKGDDPEVDIVAVHGLKGDVYRTWTAKGTESDEEVFWLKDLLPQEVPNARILAYGYDSDPTKMFESASTNMIHHHAATLVSELHFYRRKANERRRPIVFICHSLGGIIVKRALIYSSNCNLSHNIMFRSIKVSTYGVVFLGTPHMGADLARWGKMAEMLVRTVSPKSWVDSNSALITALEKGSETLQNITDGFLGISRDFRLFFFWEELKTAITGMGSHLIVEYASAVPEALPDAGKASIHATHSEMCKFRDEDSPGWNMLAGCLCEFVAQAPAAIGIKWAQEDRRNLQEQQNWVSNIIQHDIHADVGLSPPPIMPRTRSPSPDAGTSRRAIMGQGDTLFPDSISEPEDSSRRSSHVPEPTLLAIKDIPFVTPLSLQENKYFEGREEALRKLHAILQSPTQGAVTISGLSGAGKTHLAREYFFHRKSDYRGGAFWIDCKPMMRTLSTGCLDLGFSMIAEELGLLGDHGGSSSRASLNDDPKTTTRLRVMGWFGKHDNWLLVLDGANAETKEEVDLLAEYIPKSKAGSIILTTLNSSFAGSARLGAPEKLELEPVTDDEAVRMLLHYAQIKNPPDAELLAARQLVKHLGHIPLTIHSAGSYIKGKKVSISDYLRKYEKRPFVDREDLEPFHIIFDRLEESDRYQEARNLLCLLAFMHREIPVGMLTAGIKQFQSNVKLVAKDRGRRDINNTIGHLLAYSLVDRCGQQDENVQVDTLVLHSVVQDVCISRMRKSELKKWLQFAIRMFCSSFDHMETCKRSNSRFLVSDYRRYEIHGVRLLQHAKKREVDTEDLVRVLSDIKTAINDDQAGVRCSMFRSGSTSDSAPETSSPESSRRPTWELDIHNEPEPIQDYNERQPRTPTRSGASSRNPSSNRKWNTPPPNNDHAHDSDSEEPRGETMPRILYRYRPARLPHGWVPGQTPVQVPAKPPDSQVTPETVIFSPTAQFPSVPASSLQSPTEAAVAIGSSPSSSKKDGILSSVQSFLKKIWASEPAPPATTHPRSQWPNFPIAQELSHRSTFPVNLPPVGAGHGSPRPHSQGRTPLSDLDHLHHPSPFQSRLPNTGHGRSQSLPFQNPHPNSLPENFGGFPPCDTSGSNQPRTPINYPGEGGYLDMPLPVSRPFSPGYTPSRDTDLSSSPVARSVVGPRYRRASLAWSEPIIGSFPSPSPSTNTHHEFSSPAPSASPYSPLLGSSFGAASSASMRRGRSSGGTGARSPRIAMLQATDSPTYSAARMARVVSAPVGHIADGRLGSPGLGIDGVHIPFDAIPRVIVAPGTPDDEGAGGVWGPGGGNSGRRSSAPDEQLSGSEEVGSVEMARSRSEPEASIRGGRAVDERAELHRAEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A807</accession>
    <name>A0A2T7A807_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1071414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A807"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="12110" checksum="031B910DFAA61088" modified="2018-07-18" version="1">MSPLHPMNSSEVYQPPASPPDASPFGSSSPQPPPQLLVTYTDHKSNTASIVIAALSLIAIFLALAFLVVYGVYRFGIGFLQGKRVPRKGGEVICGNGALSLLMFCLPLVVVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A854</accession>
    <name>A0A2T7A854_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Beta-1,6-glucanase B</fullName>
            <ecNumber evidence="21">3.2.1.58</ecNumber>
            <ecNumber evidence="22">3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">B9Z19DRAFT_1170891</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 27">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="21"/>
    <dbReference type="EC" id="3.2.1.75" evidence="22"/>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A854"/>
    <dbReference type="STRING" id="42251.A0A2T7A854"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000269">
        <property type="entry name" value="Probable glucan endo-1,6-beta-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 27" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 27 30" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 28" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015457395" description="Beta-1,6-glucanase B" evidence="28">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="29">
        <location>
            <begin position="79"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00041472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00042025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00043257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PUU83895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="395" mass="45058" checksum="EA6F1FE6F36C1988" modified="2018-07-18" version="1">MKLSSLLLSSLLAAPGLVTAWLPEGKIRGVNLGGLFVVEPWMMQDEWNAMGCGGQPSEFDCVLKLGQSAANSAFQSHRNRWITQADITEIKSLNLNTIRIPLGYWIYEDLVFADSEHFPQGAFQYLERVCKWAGDAGLYIIIDLHGAPGAQQKFQPFTGQNSPNAGFYVDWQYERAYKWLEWMTNIIHTNPNFSQAGTIQLVNEPVQDGNTQGSMIQQYYPTAFSRIRAVESKLGVPTAKKLHIQMMNEKWGSGNPNAHIPDLTNAFYDDHHYVKWTPGVTVSRDGYMRHSCTDSRSGNWPVITGEWSLSVADNAEWNSEFTLDRADAVEWYRKWWAAQFLSYEKIDGWIYWTWKVNWIGGRNDWRWGYKQGVDAGVIPKNPLDAYRWNACAGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8S0</accession>
    <name>A0A2T7A8S0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1071103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8S0"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11502" checksum="EF419E4713AD4B04" modified="2018-07-18" version="1">MSGCNPSIFSNNNRSFNVTQNSNNTTYNFTASGDEESRILSWISPLESWKRHSDVARARAEGVGEWVLKSNEFQAWRQDGNNGSVGRVMFCHGVPGAGKTFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A932</accession>
    <name>A0A2T7A932_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1104637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A932"/>
    <dbReference type="STRING" id="42251.A0A2T7A932"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015556139" description="Cell wall protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="12361" checksum="94F35371B31F8D58" modified="2018-07-18" version="1">MRLAVPAIAIASLAALVACQSKVVQIEDGQIQGPALSECTPYLVPKPSASPIKPSNKAEQVAAPPPCPPTALPLPPTVHYPTPVATVAPCPPIIFEGGALAREYPVGGAMAFCAVAIALAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA54</accession>
    <name>A0A2T6ZA54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000580">
        <property type="protein sequence ID" value="PUU72304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA54"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="36134" checksum="7977A694FE2677E5" modified="2018-07-18" version="1">MPPRKRKTGSSFSVPSNEDPPLLLPAKSRNKRISTAQSKKPRSGIGQKIPEINVKESSHSSIPGKVPEEEKKKSSTRVLNTVKEEESGGQPTYESLTYRFAVQDTPNYRAVSQQIIVARKPPMKHSGMEVGDISEEEKAEEVNENHEWNTLEEPDKGQAQGDDNRQELKLGVEIEELAELEGEAAQGLEEGFVGAGGQCEGVGKEWSEEATDAHCEALVDIIRAGARSDSGFKKPVWVKKKFGVQAGTLTPKHCKDKYDNTTPSSTIRLAVRRVMGAYRINEGWSMEQVDNALDLFKNEAMADIFNELEDDPDYQEHWLRRQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAW7</accession>
    <name>A0A2T6ZAW7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1008883</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000492">
        <property type="protein sequence ID" value="PUU72642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAW7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAW7"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="716"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="604"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1074" mass="119940" checksum="186C5670C3BF3C3F" modified="2018-07-18" version="1">MRVYPHVHDLVARTAGLRPGDRSIKAWLELAFQSWQCARAHLGFKRQDAAYVEYLLAFEIVADIIPRCQDFPTFKSTAGRLYQDFETLKKELVQKMPEFDKVKEEIKKNNKISGVVSAQAQLEAEAQLRAAKPSSGNNGNVTAVLKKPVVKAKPDILSSRPLLDLQGMASNNSNGTGGSSSKTGKAASDDLNLEARFEKLSMPSGRPIVPSSSQRNRQSASANLYGPREMPTKPPPLDVNAMPKLPAPTYSPATSFTSPTGIPPHRSSARPSPPTQGPAGLESTGPRPAAPKETTISANTLCSYLEGSEVSVLLLDVRPRNEFMEGHIFTRSIVCVEPVILREGMSGDDLDDTFVLEPPKEQDLFSRKHDYDFVVYYDQSTSSNSFLSGSTNDQHLITLRSLHLAMDDYAFGKRLKNPPLLLIGGLDAWINLVGKQALKVIDPEAPTIVRSDARHSAPPSRESGSLERPSSQLSTYGEKPPDKSSVRSLAQRRQDRDSQRGSLPPLNRQSYKKNEEPTRPYTIDIEEERRWMERLHKESEPVGMSVISSPDEIDAKKRRRGTSIVTPSDIPHVRTVEEFVSSDLIPAMPLRFTELDQFQRYPATPHTQQSMISPSLSTPQQDRFPTSLTRRPTIIDHPFHGFTDVRNPEFNPPPSPVRPPPAVPRKSYSGVSERPAPVLPPPPPPAPERPPKIPPVTSKSPLPPFAGMGTVSIGTTGLKNLGNTCYMNAVLQCMSGTIPLSRYFLDGSYKSHVSKDNPLGSRGVLAEAFAAIVRHLWSGDYSFISPVTIKDVSGRLNEMFRNNDQQDAQEFLGFILDGLHEDLNPHANHGKLRPLKDDEERRREKLPVQLASNIEWQRYTHHNYSVVVNWFQGQLSSKLSCLACGRTSTTYSPFMYLSLPIPAMKSNNFTLRDCLEEFVREETLEGDDAWHCPQCKKARKATKKLTITRLPHILIIHLKRFTNRGPWRDKLNTFVDIPLRNLDLTRYMPPPLASDEMPRTLPPPTAETTPPFLYDLYAVCNHYGTINGGHYTAVVRSSYKTGWNLFDDSKATLIEEGRVTRNAYVLFWVRGNVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB56</accession>
    <name>A0A2T6ZB56_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1069555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000477">
        <property type="protein sequence ID" value="PUU72721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB56"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB56"/>
    <dbReference type="OrthoDB" id="5361017at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="562"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="825" mass="91866" checksum="AA0BEB3854601B1C" modified="2018-07-18" version="1">MGGPKNEKKETKRKIVGEIPMDNISIWIPRAWHNTVVAARRRELHRILQAQNRKNNTECGIATPRSLRSFFDSTPADLLDSQLSSLALISRTAYEQNQAEIATLRKQIEDKENEISSLIVKRNGVGVSTSVGAVGVAIEIGVLEVQITELQKRNEGLVGENKRISKELESSELKGKAIKAEITRLRLDGSKRSKELEERNLKLSAELLDARTAFSQLQQSIGSQSGMTNGHGIGSSGTMMADSEATLRELRSENEKLLTRLRSSESGKADLHRINKELRTVVKTNENSNVDLQKGNLELKVQISSLESDNQKLQKKSAKFDMVVEEKEELEKLVANLRTEIEKLRAIPPVNNNTGALEAEITKLQNEVEHLNSQLKGNSPGFEAANKKLVNDNIELAKENEGLARLVEAEKMKLIARDAEIEILNQRSQRLVDLKERLRDENVALRSQKERLLADLGDMERGLRIYRAKAAEPKALKAPLDKPFEHIPSRKDARRNSGIDSNGAHGKSHENSISPRGQGMKRSLDEMEDSGEEAAGDIDCSLIGGNGNGSSRNFSIRAIASEANGPAPAPPGVTDSPTHISTSVPTSPTGRNLFERVGGLPSRSLFERISLPLKPPPISPVSRWSEDREIEHLVSSTKTGKRCIICRFDGGGNPPDPAGLLSVVCGGPLESLRIMGDRNMGMLCFLRPHNAEEFLDYAERNLNGKRVFRDEHCVVDFLWQDKAIKPIEKEIAHHVVHYSRSRIFKFHCLPYETPLERCLAKITSLIGDRKLWLNEGHRGQRGREVEVEFMSIRDATEAKRLLDTQATAWGGISWCRDECDRPIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC05</accession>
    <name>A0A2T6ZC05_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Exocyst complex component Sec6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1006704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC05"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC05"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="785" mass="88965" checksum="346AA885276AF031" modified="2018-07-18" version="1">MDEADSISVKLTELLRHPEDLDKIASLKSEFSRKKGHVDTQLKAALATQLKVTQSGIDAINDGQKILNAIREEMIKIDKLCSEAEDMIDEFPLINKISKIHRNFVAVEEIKSKLQGLDSRLAEVDRMLAEDSGDSLGNEMPNLLPVHFAIMQLQDFKEDVMHQSERADNDVKETLESYFSPLENTVGMFDERVGIIAMSLIELVRAGNRSLVVRLAKIIDSEERSDEKVLALQEAQNNHQDLATRFKSIQKGPKVARGYKEKFLACVKAAAQAKFGAAKEQFEGDPEGLEHCLGWYFNDLRTVKTEFVQLMPRRWKIFDTYLEIYHNLMHDFLKDQIEKPDLDGQSLLNIILWNGEYNKGMKTLGVKAAELKPQLIDGREAELLKEYSQLIVKKMEEWMNKIMEDDTKDFILRTHQPNEEDSKWHMPSVPTMFTMINQQLNVALDSNKGNVVTGVVDECVRLLKNRQVRWQEVMADEINKHVKATTKEDLEDLPDGILEYMMAVANDQIRSAAYTQEISDRVAPMLSKKYEDQVRRALEDAMNGFVDLATYSLAQIIEIIFNDLKPPIKNLFTPAWYNGSDMETMATTMRSYIVDLSPGLDADLFPAFMHQLSEKTCVAYLGGVHNKGAKFRASEAAAQIRSDVAVGYGFLTEFVDRGEVKGVWTVLEHFLALICSEKPLLGEKYDAFKQSYWDLPVTWVEAVIKCRDDKSKDMLEIVRSRGTYVPRGGESTIMSRFVAPLVVSLGRFGLTVFSCSFCDDIGSSDCISMVLVAMLYILMGFLVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC09</accession>
    <name>A0A2T6ZC09_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptobrevin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_937688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000423">
        <property type="protein sequence ID" value="PUU73030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC09"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC09"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="90" mass="9888" checksum="33A895AFE5A7A784" modified="2018-07-18" version="1" fragment="single">QPYDPYIPSGSAPGSQGQPGGPGNQRTAAIQAQIDDTVGIMRENINKVADRGERLDSLQDKTDNLAVSALGFRRGANKVRKDMWWKDMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC57</accession>
    <name>A0A2T6ZC57_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1197177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000423">
        <property type="protein sequence ID" value="PUU73026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC57"/>
    <dbReference type="OrthoDB" id="4175694at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="28381" checksum="5DBF5DA403455F9D" modified="2018-07-18" version="1">MSSPISAEFHRPARISPFVPVGILERVGIKLCIVGNAVVRLFGSDLVMADLDLAISDEQFDLALSVLHDEGFRDVDFGPGHLVFLPVLGKPGGWVACRLQFPSSPEYVVLSLASCWNLEINPDTTFYPCPGYRFPRFLAYLEALICTIDALVSVGDNPSLPRYQYAIMMVLLEKRPELEGMVSPGDQFFMDFFMKQRARSGELRVLELRKGIMAGTISVDAARAVVPRPDLSRRRIKEKYLRQGMGGGNGQGSTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE16</accession>
    <name>A0A2T6ZE16_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000349">
        <property type="protein sequence ID" value="PUU73738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE16"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015476169" evidence="2">
        <location>
            <begin position="23"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="23800" checksum="395016E5077B6148" modified="2018-07-18" version="1">MRSSSILAKLITLASIFGIVAAQRSPSTSSTAFPTTVTGVIPTTCPAGGQCGSGDLGGTAPPTAIRDTKNTMSILTGSLKSDTSSPLTGGNPTNTGASGGSATTKSGSTPTGGTGDTTKSGTTPIGGTGTTTKSASTGAGGICDTTKSASTPTSGTGTTTKSNSTPTSGTGSGSGSGSSSGSGSGSGGSSGSTPTGGTGSGSGSGSGSGSGSSSRGSSGGTVAPAATTTTAPGGSTGAAARNGRGVVAVVLLGSLMGFLGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZED9</accession>
    <name>A0A2T6ZED9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000337">
        <property type="protein sequence ID" value="PUU73868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZED9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015767104" evidence="1">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="15636" checksum="F7122DAC9685BFD8" modified="2018-07-18" version="1">MAQWLNSSLSLPHLLIPLQCSSLSNGPVNVTNDELDCPWGLFLLGTPLQVRPDPHCQKNFDGFTSGLHGTELRHSRNGAILNPTTMTTRMKQGRPKPAINHTNLLRDPRALSQFSTKDDLVLAQGWKREMYTSSPFQRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEE6</accession>
    <name>A0A2T6ZEE6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1103744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000337">
        <property type="protein sequence ID" value="PUU73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEE6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEE6"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40812" checksum="AA878D3329F77D71" modified="2018-07-18" version="1">MAQPPPSSLLPRYAKNCLIGFSRSDSLSFVLPTAIVIKGCLAVAQQPSCLTEGADLSCYLSAKRGIEDLDYFIGDESSVQALGQGPHGALLPLNPSESCQNTPEIMLETFNCAELYIAWQAVLALVASCTSSRVQDQSLTITIVDSGDGVTDVIPIAEGYVIGSSIQSIPIAGRDITEFVQSLLHDRNEPDCDLKTAEKIKEKFCYACPDVVKEFTRFDREIEGFRKSVVVQPKGRKVTVDMLFNPRIHTSDFLMPLPTVVDTAIQRSLIDVREEHCSFWCSTLYLVFGRCFERDIRHRVDACIRKSEEKSGGFWSGGLEVQVIAHQRRKHGVWSGGSLLSQSPEFRSYFHTRAEYDEIGPSLVRSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFI3</accession>
    <name>A0A2T6ZFI3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spt20 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1117008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000312">
        <property type="protein sequence ID" value="PUU74232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFI3"/>
    <dbReference type="OrthoDB" id="5429213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021950">
        <property type="entry name" value="Spt20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13526:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SPT20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="2">
        <location>
            <begin position="148"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="336" mass="35528" checksum="89A5180D92A51B41" modified="2018-07-18" version="1" fragment="single">MSTSTSTSNATPLPRIKLNQSGAAGSGQRTYTGKHPPPGHSSRSNGSGTNARPPPLPSPTPSVSGGNAGNGGGANGVNANSAGARISERRRANNKAGGPGKLKGGNADNRVKGASGGNETESVPRLTKKLGTKPYVNTTSVILQKYQGQPPSIVLHLHSQHFRFDGQDGTFGYTSPMRVILECLRSEIIPHEVVEEFRDAGTKFYDGCLIVQIHDHRSASTASSSKANDNKVIPHSIHNHNESLTPSPFVPFPKEKLVAPERSMGGGQSTVSQGQTVGSEKKDVSLPSEAKKDKGEKDIKAEKKIRIFTTVLHPTQLTLHADMAVMASTPVPSRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFI4</accession>
    <name>A0A2T6ZFI4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_469046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000311">
        <property type="protein sequence ID" value="PUU74261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFI4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19449" checksum="26AA44BAA4A01D8E" modified="2018-07-18" version="1">MHDQGWIYTYPDGFSSSIPLGLQYSIGLPKKFPSCLPFQPGLTVLELSLNTKPEVLVPSASSFTPLKKTFILSLQITISELLLFSPPTLIISIRQLGLLLTSPILACWYPRARPPLHRSASSRHHHRLLPVSYCTSTIFHRKGGITKAGKGFFSFTNFSWLEKFGSVRTSPLSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFX3</accession>
    <name>A0A2T6ZFX3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000303">
        <property type="protein sequence ID" value="PUU74385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFX3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="106" mass="11636" checksum="5063861AEFF9A9CE" modified="2018-07-18" version="1">MNKMLIAGYALVRRKPQILIIFLFFLPTPLFVLRAVAILVQYSTGMMGKFFLDLVRFVLDRRAGLGWTGPGGGGWSGGTRTVQHSKGQIAKSVELGIGLRREGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG16</accession>
    <name>A0A2T6ZG16_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1000636</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000300">
        <property type="protein sequence ID" value="PUU74427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG16"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG16"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="248"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="579"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU74427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="736" mass="81443" checksum="93220E2053193242" modified="2018-07-18" version="1">MVQGEAPSTASTASTSIVGSIANRFSRSSTASSQASATTSKPPLPPRNSPSAEIIAPPPPPAPPKAAPPPRRSPFSWLRSSSTNAASATPPPPPPPPQSSSRRATASSIATVASLFAPSAVATQMNSELLLNRMESNRGDEKEKDSVLRGTQTLKESFRKLREARERTAMVSDDESTKEVGSGDSVSSTAAAGTSVGSSPAPEDSTVPGSNGSQEEEIDWDLWQAVVDDSYKVAAEKPSELNRAIQAGIPPTLRGTVWQSMAASKSLELESAYQDVIALPGTATAEDARTLFGGHWLWDPSPTSSQSSSPKLGSSTSPKLDPAGVKGPNLFWGKTVAQLEKAIKRDLGERTSFGKYKVDQKALMGVCKAYALFDPRVGYTQGMTFIATVLLLNASNPSPRNPSIMTEEEAFCVFVKLMNKYKLRTMFQEKMKGLELRLFQYDRILEDYQPRLAIHLKRQGIESSLYAAQWFLTLFTYKFPLQLVLRVFDLLFSEGLEGPILKFGIVLMGKNAETLIGMGFDTLGPFLKERLFDVYLDTMPSATSVKEAGFFGNGGEKDFYRANQMVQDACAIKITQDMLDRYEREWDEIMRAKREHEMELETLRRTNASLMIKVKKLEEQNEELNREYVNIASSEVGLKVQNDQLADENEVLKAKVEGLKEIVDKQPQEIEQRFKEEMDKLMTRTLEVHTENQNLEESMLEMEKDLVGTKMQLATVNEDYDLLKNRWNDLRKALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGD6</accession>
    <name>A0A2T6ZGD6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_933869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGD6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGD6"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="706"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="770" mass="83561" checksum="5B88228DAE96FBF0" modified="2018-07-18" version="1" fragment="single">MDSEDGQTYIKHLAHFVRTHEKALANALQLQTRRQTRRSDTAPAVSGRTPANLQYPHGSSTSSTLAAAFSLPSLSFTSQHLKPAKLGLTPHHLYYLLSRFEELNIPVGPMGVRLENIHAESSPGNYVSFLRDTSRRRNHSSDSLSIHSVSSVRSVMSGVSSLWSSIGLGTSASVKSEKAKAALEADLKYLYSAFTKIPCLRLAPDRKARLIEGFEEFPFDTAVPLLAFKNISALEICDIDIRQFFGWDQLAERLRSLVVKRGGIKDPAELIVAIVLDDMDKRRWRSAKSSSSPIISYPSSSPGLGNEGEPSTPPSPTVGQIGSSSAPAGHYHAMSRVPSGSSRSSSKNRPRSNSPTRPASSRTNSNATNSHSRSHRMRRSGSGSSHSSSTSTLLPASGHGLTLPANLPNTKWRFLRHLSLAENDLISISSTALTPLAGSLSSLDLSGNLFKSIPECLSILYNLRALNLSGNMIDSLHSLTRNPLPAITALNLRGNALASIAGVERLLSLERLDLRENKLTDPTELARLTGVPNIAEIWIASNPFTKTHSSYRVTIFNLFRETPGYSDDISLDSQKPGMMEKRNLKDRVAESPAVPVMRVPPSPTVAVNTVSPIDSKKKDKHDNEKIIKIGNGEVARAKKRVGRRRVVELSRDDSSVSIHQETQSNTKPTAVRSASQSRPVVVSPPKPPTAPKEIYHPPEETSSGAESSPPNHHSSPSENVDWAQKGDEYRRKVEALKSEVGSGWLSVLSEEGMSLAPSRKASSPSTPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGT2</accession>
    <name>A0A2T6ZGT2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1055840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000288">
        <property type="protein sequence ID" value="PUU74614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGT2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10402" checksum="CC73B24B2D20AB34" modified="2018-07-18" version="1">MRDSPAAPLLLFLLYGPSYPSASQESLDLKIGCDADVHLTPHSYQRASPSRAGRIDERHHRTSCRSPGRHSCSPSLRLFPPSSACTSIGWEDSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGT6</accession>
    <name>A0A2T6ZGT6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1132774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGT6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17374" checksum="2A54C26CF3C8BC91" modified="2018-07-18" version="1">MLRVTRLAMRTPHRPTFRMASSVTKAGLDKADMLAKMTNLKNARNTYPTDFGIYKAELKHLGDKMDIKFQHLSELLKLIREDVKNSNGDVKLLSTRTDGQFAKTDRWIFAILAFAVGKGGYDEIKDHGGLRGITDTIMGPREAPPPSAPTPPPSPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGX9</accession>
    <name>A0A2T6ZGX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_998521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000276">
        <property type="protein sequence ID" value="PUU74745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGX9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGX9"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="248"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU74745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="529" mass="58294" checksum="724698DBCFB12E89" modified="2018-07-18" version="1">MMDLDGGSGVTAGPVLGSGQKWGSPVIERAKPNGAIGVDGRDSQGPHHLAPQQQQQPQPPSNSNNNSNLSQQPSSQPSSGASSQRTSTVSPSNKEQPHPPPSSLTPQTKKSTPTPTNINPRHPLSQPSSNPKGAQQLGPPPTPSHNQAILEGGNSGSPGSSGPPKKRARREETPIWARKKDSRSSSSSPVMANRRQPSSANQHQPPQQQQPPPPQQHRKPPQASGFTSRFVPCFGAWEPSICNAEPYEELTREVVNFLFDQVVCQNDPALTPSGGDSQVVMIEIEAKIGHLIDKERGERLKLPVITETVLNVDEPGWKIQFKSSMTEARLLFIYLFSSTPSRDVNSRPPTGPQRISMDYVHTREKDTFFELPPDKLQALPNILHVHMRHRPKVRVTYDQKTGKVINKIIKARIADLNVYSPKTAFDWRVSANIEMPYLGDIEGLQPSSDRGGGDRNKDRLSYRHLAYQIDLTQVTDNTAKKEHELEVEVSGQEIIKHGNLARENKPNAYESLVRGFVDNVRVLIRAIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH03</accession>
    <name>A0A2T6ZH03_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_998414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH03"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH03"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="3">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8367" checksum="B05C2C5B201A82A8" modified="2018-07-18" version="1">MYQKLSDASEVIDDRVDKFRDMVQEPNELANEQFGNPSTASPSEIIAVGKVDGKLSPSCVLLEASRKMGAGSRVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHL0</accession>
    <name>A0A2T6ZHL0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1054925</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHL0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHL0"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="128"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="419" mass="47431" checksum="C2D6BE9CF55C4349" modified="2018-07-18" version="1">MNTSQFARLLRKIPTKILRKPLCRSVSTDSAISRGLRRSVAADRYYDRQKDISKYDYNPEPTNYQNSPPLNPTIRRVAARREGEPEDDYFKPEPGPELSPRLDHEPPQFSYTPAPRRYIPKVNYDAEWIYGTSVVEAALRCKRRELYKLYVYAGDNRTPAARERDRDMKDLARTAGVEIVNEEDIGKMDSMSNSRPHNGYVLECLPIKRTPIIALKDVQEDKNFFTLEMAGHYFDGRPVTEHYYDKIRCRDPKRRFPFVLMLDEISDPGNMGAILRSAYFLGVDAVTITTRNCARLSPVCLKASAGAAELLPIFEHAKSERMITQSTENGWTVYAAIPPPTKNQARRDRYVYASEVTKAVKEGPVVLLVGSEGEGLRPFLKKLAKFCVSLDKGSGTDSLVDSLNVSVATALLCSKFLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHT0</accession>
    <name>A0A2T6ZHT0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1132053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000254">
        <property type="protein sequence ID" value="PUU75050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHT0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHT0"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="8">
        <location>
            <begin position="73"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="41693" checksum="B4B7DB407A0F1AEF" modified="2018-07-18" version="1">MNLLSRYLPERLGGHSVPFFQPRHAFQPPPVDTPPVNPPLVNPPLANPPAVDPTKGSLKPVEAHGEFPRKDWWDIAAGVVISRPPLLTRDLPEFEQSYYFYQRRLNDRLQLPFARWFYFKKGTLAEDEWKRKQAAEERYQPYGPRAWADELLKGSTEHKLDPLKDYERLVATTVTGEEETMSIMQARRESAKEAEARGEEVEYPPEIVEKPFPRTTQADIENNTKRLDRKMSRTLYLVVKKKRDQHAWRFPQSRLSGKWEHLRWGAQRTLLEAAGPNMNTWFVGSAPIGLYKYKYPPGYAQNQVGKKVFFMKARILAGQANLTNNKQDLEDFQWLAKDELKEVVGNKYYKAVQHMLVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI72</accession>
    <name>A0A2T6ZI72_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1091088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI72"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI72"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40766" checksum="2E135AF82F50F0D5" modified="2018-07-18" version="1">MKKKTLLLCFIHGFKGDDDTFDRFPFDLKALVGHALPQLNIESVVYPRYETRGDLTACVARFREWLQTRVIDLEVAAGTQSPTVDPSVRTVLVTHSMGGIVAADTLLSILDDQVVKSGPNSPEQFMFPYIQGILAFDTPYLGLSPAIFAYGADTNLKTASTAISQVSTLASGFFASRAATEGSKALEQAPSEENKGKEPEAPGFWSQWGKVAAYAGAAGALAAGGAVAYFKRDELGEGWGWVSSHLEFVGVLVKGEELKNRTERVSSIEGVGFANLYTALGDRGKDKGERTFCILPQKGGKGWFRCTNTKASDEVNAHVSMFHPKTNPKYFELSQLAKELVVRWATNEWSYYPGPPSRDMRMSVGGRTPGRADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI75</accession>
    <name>A0A2T6ZI75_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1154796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000247">
        <property type="protein sequence ID" value="PUU75156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI75"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI75"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="29413" checksum="FB67F5DDEC518994" modified="2018-07-18" version="1">MAEIERFVDPLDKKHPRFPEAADKVSLRFLPRAIQAEGKTTTVEKTIGEAVEEGTVDNETLGYFLARIHLFLKELVIESEKVRFRQHMPNETAHCAADCWDAELLAPYEWIECAACSQRNPRASKGLEGMDIDVDMKWLGPKFRKDDKKIENAVARISQEDRERLAALQEAGGKVLVEVEGPGSLDLEQVTIAKNEKSVNVREYTPNFIEPSFGIGRILYSLIEHIYNREAQAEWCQRSLVIYQDLQPREAKLQWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIG2</accession>
    <name>A0A2T6ZIG2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1195608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000239">
        <property type="protein sequence ID" value="PUU75273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZIG2"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="866"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1677"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="2256"/>
            <end position="2573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2408"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2557"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2418"/>
            <end position="2428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2566"/>
            <end position="2586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2586" mass="289507" checksum="594F185A081A6164" modified="2018-07-18" version="1">MTRTAAGSATRNGGTKPMKNHTFQSFTQQLQNLKIDPIRKVRRRVLDEGSESSFFHSALEKWIDLNLSTTFVELFVRPVRPLSESLPHILHHKERIFGLLVDGIKTRDVNALEPLLDLLTQFAHDLGVEFQGFFEESVGLLAALVTEGFVEAQVVEWAFGALAYLLKYLSRLLAGDLRPLFGVVRGMLGRGGGRGFVRRCAGEAVGFLVRRVKVEVVRDLARTVFEDLRGCEGAWVSGYMEGLMGLFREGCVGVDRGLHSKAPIVIESLIQVAKEMGEDIGGRCFKIIEGVLISLIHHTNDDTFRPALQVVYAINNSSDELSTRMSARLLYTCFTVRKGSRISDWGSAGEVTVANIQTTMKLSNNSSGERAKETMWESLKAAAMVVQTADMEAMIAQLGQIMDSVRGFRDGQLFLPFCEFLADTGAERFRIFMLPYFQRFLTAKWAIAEDNLLYLIPKLGANGSFVPSGDSDRISMAGVLGSKSPVIAGAINNIQGFCENIKGGDRDALKTRATRVWGYLNVILALSGSLQGEQLPSGLVDALEQLLNGLLSLPGNTEFAALTGMVLTVSSKCPLMGSRNLEEPLAMAFPKLADNAVFLQGVVDFFSLSTAKKLIDKDLTTMVDKLIANLSSSSHDIRSHSLRCLELFYVAENPLKQVPNAISTAQIIENIPLEITNARNISLYVRRLAGEYSSAAKGSWESRIVPYFCFGLLTVHFSPVWDDAASTLSKVAERDEEIVAMLAFEWLERQHGASPEASDNGTSGGGKAPLHGFECSNLSMVEEIAGKCVVDGFEAVADLGRKYAEDLKTPTLSTSVARMQALKVLTEVPRIAEKRSRKLVPMFLEWSTFEDTEDGEGEEETKTQSKWLRKEQFAMLTLFTKFTNPRSLYKSGAVYSALLSLLASGDPKVQALVLKCIFTWRIPSIRTYEDNLNNLLDDTRFRDEISHFVQIDKDESMIQDDHREKLMPVLLRLLYGRSLSRKNATSGKKGMESRRTVILASLADFEQWERELFIDIALGNLAEVSKRFVEKSSEKYILHIEALGTVHVSNRKQMGFVRMTEDMIRQLGSTIFPFMEKIMDALLYCLVMATKTINSWGDSTNEQGNAVAVKAARAIRQGGFKCLGALFNSCPTFSWSHYMPTIFDELVNPRLDALPIETSQGPSGLLQLFSTWANSKDTVMFLADYNLTVLSKIAACLANKSVKDEVVLFIVKMVKQIVSLVNLEGGVRPRLLEPNVDLLLVNLGDILHKSPGKEVLEQAVETISKIAQFVSGDMETTHLVEILVFLLDQPSRRVSPKAKSDVLKILLHFLPLCTMEKGSKLYEDTYRCVSSLFGFFKDREGRETLAGVLNVFAERDEELVQVAELCRKLNSFSHRRLDEPDFEQRLEAYGKINEDLYLQFSPKQWVPLIFNMLFFIRDNEELAIRTNASYALKRFAESCGQKSGTEEGEAYLKILSETLMPALKNGAREHSELVRMEYVVVLAHIVKECSFWEEVSDMKALLVGDDEEASFFNNILHIQQHRRLRALRRLAITSQRENIQSSNIAHFFLPLVEHFVFDQAEDAHNLASETVVTIGVLAEQLTWTQYRALFRRYTGYLKSKPELEKIVVRLIGTVIDSLARAAVAKENAAAAVKDGDGDVPMGNAMNRLAESLPEQRTLAEDISKGFLSSLNQYLHQKEESTVSLRVPVAVSIAKLLKLMPDDMLRLQLPPVLTDVCHILRSRSQESRDMTRKTLAEITTLLGPQYFEFVLKELRGALLRGYQLHVLSFTMHSILVSVTPTYSPGALDYCVDQIMSVVMDDIFGVTGMEKDAEGYISKMREVKSSKSYDSMDLVASVTTLPHLGSLIRPISALLKENMNLRMSQKIDELLRRIAVGLLRNKEIDSEKMLIFCYEVIQEGYKQDSAEAREKEVDLKTQRYLVNLKVPSKAASGVTTSSHMYKLSRFALDILRTTLQKHDNLMTPRNLANFIPVIGDALLSRHEEVQISTLRVLTTIIRTPLPAIDEGAEVFMGQALSFIKSCPSMNAELAQASLKLMSSVLRERRNVKIKERTIGYLLTRVKPDLEEPDRQGVTFNFLKAVLARKVIIPEVYDVLDGVAAIMVTNQARSVRDLARGVYFQFLMEYPQGRGRLDKQLAFLLKNLDYVHQSGRHSVLEAVNLLCTKVGDNLIQQILGTFFVPLVMRLINDDSSECREMTGVLLRKILERADADNLSTFTGLMRNWLGQDQKPLLVRSALQIYGLYLDASPTSARKDLPFVIGKLQSIIQTSSIDQDVHWENLYFSLQTWAKIVVLFPKTAFSADQAPVWASIHDCLPFPHAWVRLSAARLTGLLFAEYAAKATLSTTPLNNGAGLTLSAEAMIHTARRTSSHLNSPELSEELGLQVVKNLLFLARCFHAAGVEAISSIPANDPELDDVEEEEQRHEEGGREKRRSALEWLVQRISAILRSERNIKKGLLGKRFAMQWIAALIQFLPKGDLEPLAKILIRPLYNLLEVSGMHLMKDLKPTAQELQSCVAEKLGTTLFAVVYSQVKSEALDRRRARKGKRAILAVTDPERAAAKKIKKHERKREVRKEKGKVEREGRWGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIK5</accession>
    <name>A0A2T6ZIK5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_995186</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIK5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIK5"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU75311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="998" mass="108520" checksum="9F0C7BB588693699" modified="2018-07-18" version="1">MDRAYARTTEDTLKFFNVDERTGLDGQRVETALLRYGRNALPEEPPTPLWQLVLEQFKDQLVMILLASAAVSLILAFLEEGAGLTAFVDPAVILTILILNAVVGVSQESSAEKAIAALQEYSANEAKVIRNGHVTRIRAEELVPGDIVDVAVGDRIPADCRVIAIMSNTFRIDQAILTGESESVSKNTRPVKDSMAVKQDQTNMLFSGTAVTVGHARAVVVLTGNSTAIGDIHTSIISQISEPTPLKQKLNDFGDVLAKVISVICVIVWLINIRNFGDESHGGWLKGAIYYLKIAVSLGVAAIPEGLAVVITTCLALGTRKMAAKNAVVRSLPSVETLGSCSVICSDKTGTLTTNQMSVSRAFVIGESQMELDEITIDGTSFSPVGAIKNSSGNLLESVASRSVTIRRLAEIAAVCNDAELSYDPKTQTFSNVGEPTEGALRVLVEKIGTPDTTLNLQTSHKAVEKRLDEANRYYESQNPRLSTFEFSRDRKSMSVLVGDARNPRLLVKGAPESVMERCTHALVGSGGQKVPFGPKARDLVNAKLSEYATRGLRVMAFAAVDDIGGHPLIRSATTTQEYAQIEQGMTLIGLVGMLDPPRPEVANSIKKCRDAGIRVVVITGDNKQTAETICRQIGVFGEYEDLTGKSYTGREFDALSETEQLEVAKRASLFSRTEPTHKSKLVDLLQSAGEVVAMTGDGVNDAPALKKSDIGVAMGSGTDVAKLAADMVLADDNFATIELAVEEGRSIYANTQQFIRYLISSNIGEVVSIFLTAAAGMPEALIPVQLLWVNLVTDGLPATALSFNPPDHDIMRRPPRGRDEALVGGWLFFRYMVIGVYVGAATVFGYAWWFMFNSEGPQITFYQLTHFHKCSTMYPEIGCEMFSNDYAKTASTISLSILVVIEMFNAMNALSSSESLLTLPLWKNMKLVYAITLSMVLHFALLYTPALQGLFSIVPLNLHEWKAVVYISLPVIFIDEALKFAERRLYLQQPTNKAKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIS1</accession>
    <name>A0A2T6ZIS1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1154042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIS1"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="85" mass="9892" checksum="1F10F1FE097D5348" modified="2018-07-18" version="1" fragment="single">KNNLNITRILDITQELRFLSDQLEVENAPFVFDGSQKRISESRKVASRNDQQTWKRLCNRNLLILAGQGGSRVYSGERRWKAHYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIZ6</accession>
    <name>A0A2T6ZIZ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1067383</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIZ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIZ6"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="189"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="525"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="666"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="807"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU75467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="933" mass="104292" checksum="CF76F83EEB273A5D" modified="2018-07-18" version="1">MLEGTINGSPSPGSEGVRNIHLGDSPRCSSAGVGRYSKVAVPDEPKMEASRGSSKASSRGNTPSSQGSEASIKQGNGTPPRKSQRAAPRKSARKPPTLFADFPDSTQEATSTFSLIDECIYSTKSIGDSGQDGEVMSCECRTEWDGECNAACGDNSDCINRMTSMECTQDDRACGQDCQNQRFQKRQYADVSVIKTEKKGFGLRANSDISANTFLYEYVGEVIDENKFRRRMERYDSEGIKHFYFMSLGKNEFIDATKKGGLARFCNHSCNPNCFIDKWVVGEKLRMGIFAKRDVRAGEELVFDYNVDRYGAEPQPCYCGESNCLGYIGGKTQTDGAAPKLSHHIIEALGLEDSEEWSTATAKKGRRPKKTDGDDEDYVESVQSKPLGEADVTKVMSSLLHCKEKWIVNKLLHRIQLSEDEAVPARVVKMHGYQIMGRILHDYQSDENIVLMALDILMKFPRITKNKITSSKIEPTVQQLSTAEDQRVQEASKALLEVWSSLETGFRIPRRSKADMERTRSMYQAYERESSSKSKSNSPQLEKPLTPNGPNRPRPFAKSGFQNQPPRGPRAEQFQRHNDKPRRDLPWGWHKAHTVDGKFYYYSNDGRARWEVPQEPCNSDARLPHPPPPPPRPGEYPSRPAEYHYIPQDQKRIALQAIIDDITRSRSTEKLNKQEQERLKEEERVRQAEQEADSKRAKEMLKEKEKAQREAEKLKPPKIYDDEKTKKILIRAFSTVVANAVNKYESQIGGRDLVKKHAKDITELLVKKEMKDGRQIANPHLLLESDNKRLKVKGFVKPYIEKVIRNKLSMDSRKREKQKGSSSSHKPESSSSSEKNKEVVASESSPIPPVAMSAVADGVETSTGTSMIGATPLATPGKRRREEAEEASGNLDIVADNEGGDPKRPRPSPPKDVTPPPTGVTEVMAGGGGVYVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKZ5</accession>
    <name>A0A2T6ZKZ5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1088832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKZ5"/>
    <dbReference type="OrthoDB" id="5322575at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="16511" checksum="4BA96BE1BB61D712" modified="2018-07-18" version="1">MARRGYYAVARGKPPAPAIYSSWAAAQVVTQKYPDVIFKKFRTFAEAQAFMAEHGVVRYRVEITFDVTCITEESRSPTISSGVSPPPPSPSPAPPAALVSNPSEQGRRGRVKVGGGTGGKQFYVVANGSGKGVYESWLVSFVPFFSQSSRTTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL98</accession>
    <name>A0A2T6ZL98_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1088787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000197">
        <property type="protein sequence ID" value="PUU76194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL98"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL98"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="440"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="586" mass="62183" checksum="78591794EB3F10F4" modified="2018-07-18" version="1">MTNSGVATDDRGAKSPSQTPLQSIARESDKDDNSVIHEQDMDSLEPAHTESEAADDEDSGSLSGSSDNERVREKLKKTYIANERPESAAASEGQKEDGEPRATDSAAASETGQEMGEEKPRRPRKRSIGETDPSEDVNMGNEGHGKEADSRHRFHERKRSREISDDDMAKAARALSRVKTPPTHPEEDEIMGHNDGLHSASSAMTSPRKLERKRSRNRFDEDDKDKDADRRKKMVAERKGERDSGMGADTATPASGLTNGKAFGKPEVARVSSIEADTKSEPKISASSGFGNTSTKSPFATTSAGSKPLFGGPGSSDTFKKSAFGAMSGSAASPFATLGSTPHPSSPFGALGSTTTKPPAFSSGFGSSYGPSGFGSLGGKAGDVISSAPKLSGPIGGTAAKPFGAPDDDDEKTDDENGEGSGVEAHKETSSGKETFTQQEIATGEEGEITVFKCPGKMFSFDKENKVWKERGKGTFKLNTKGSKSPISASAFGLDDTPSISVTEGKKSARILMRTDGTYTLILNVPIFKGMIFGDHAGNKPASNQFLLLIPNSNGGLDSMTLKLKSAAHAKELYDHVRNLHEELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLC2</accession>
    <name>A0A2T6ZLC2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1088605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLC2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLC2"/>
    <dbReference type="OrthoDB" id="5404940at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="386" mass="42978" checksum="C6F3B358CBE6CB50" modified="2018-07-18" version="1">MHSSQLQRPYLPFATSDPENESLRSFNPKRISEAAAWPLPPRPTMTAPYIQLDLQRQPMGRVQQRSYAKIPKKAIKVVRTLSIVLRIFQLVGAMGLLVCMLFVRKVDEMTGWICRVPPAVAIFHTVYSIYHLSGSYRVRTPSSTIGYLLFASIVDIAIISFYSFIAVLSWRQHSLGNEMDWATIFTKDGSDEKIILAVFLDACVSGGLTVISVLFSVYLTLTFRRLANLPPDANPFLEHKGSLTRKPAKRISASTLASQKSVPFAATRHPRPIDIPSPTEPTRFSYPQAASTASPRASMMSEAPRYSAISLNDSPRNSHDMSHHPQIESPQSSPRGTKKKTYAPLQVNSPKRSSGLRDSRATSANLGAENESEWRYRKPSAGDSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLG6</accession>
    <name>A0A2T6ZLG6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1129979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLG6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLG6"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="584" mass="65072" checksum="3FB8224B3D30C083" modified="2018-07-18" version="1">MNMERIVRKMSSLSYLINRPAAQRPSPVPTAAEPPVAPAQEARRLSPALPVLRLQPAPKRSKEPVSPPPWLPPAPPGPPGTGPITQLPTEILLQIFGHLPTAKDIGVATRVCRRWYVTALEILYRGLEIGRFGLDSAAEHKLFVQVASHTFQNPELCAIVKTLTLRSQSFINSTYVFPAQPLSNLTSLEQLTWLAVDLVLDSYQSSQKPLYGVINGLKLPQSIRRLHIGLRYYMNAERDLGYISGEDLKGRLPHLEEFRYSRIRLWSELVGKQKLVEEEAQGKIVAVNDDAAGESDKLGEMDKSPALFQVIIANLSPLTTLQTLTLDCPLNPASFTYTLTPALQQEMRVSFLTINSFLFPPNSTPPFGPLDREVTRSARDKLLRLTTIQLYELSVDVSDEAARRIATTGDENATDMPSYLPSIPTFHPRRNQAREKLATLITRRFAALLTDVLIEIRARCPRICTLREFVPAPEFPRRGRCGDSKAHKYVIERIYETLEDVGLRNVVCLKARMGTGDSEWVKVDVWRGNAGRAEVASLVPEASAKVLNEGIKVTYSHGSVESIRRGVLEEVGGGRWRIAEALEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLR7</accession>
    <name>A0A2T6ZLR7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CobW/HypB/UreG, nucleotide-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1115870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLR7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLR7"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="53"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="27753" checksum="04F6225F49F6EE70" modified="2018-07-18" version="1">MSHTHDHPGGHAHSHDHANAHGHEHEILDGPGSYLARELPIVEGRNWEERAFTIGIGGPVGSGKTALMLQLCKNLRENYSIAAVTNDIFTKEDQEFLVKNEALEAKRIRAIETGGCPHAAVREDISQNLHALEDLHREFDTQLLLIESGGDNLAANYSRELADYIIYVIDVSGGDKIPRKGGPGITQSDLLIVNKTDLAELIGADLDVMDRDSRKMREGGPTIFAQVKNGVGVEDIVSMILSAWRASGASGPRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLZ9</accession>
    <name>A0A2T6ZLZ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1102325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000186">
        <property type="protein sequence ID" value="PUU76503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLZ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLZ9"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="792"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="934" mass="103614" checksum="3DCC666D7D1B0FFA" modified="2018-07-18" version="1">MALSGTTITAAAPDSAIATTTNTARQLTTTDNSSAVVGQKRSTTAAGNTNGSSFRPVKRRASKACQCCRARKVRCNVVEHGAPCTNCRLDEVECIITESKRRKKLWGTKVDNTGSASDTGADTTAQAQTNASPSGRKTNACHNTESHTGISGSPSALPTDIHSDRENSGHVPHLIYQVQGLRMGRDRRASYASSHESLPSLANSLSTQTSASSSHPRRLFTISQACIELPAFIKPTPIKIPLDDLEYLVKKGALTLPEEPLRSELLRSHFDFVHPYMPLLNRKEFLGSATSDDGSKGKISLLLFQAVMFTGSAFVDMESLRAAGYPTRKAARKAFFTKARVLYDFDHEQDRMSLVQAILLMTYWYETPDDQKDTWHWMGVAISLSHTIGLHRDPANSNMDPDRKKLWKRIWWSCFMRDRLVALGMRRPTRIKSEDCDVPMLTLDDFSIDTGPGGDEDSMFWSYGERQRKEMESRRQRELAILCIQKAKLCMVISQVLSAQYSVLNTNQGSLAADGSTRTTMMLLPKKLDPGCCQVEKCDEELARWVQELPEEAIYRLVGVNAPVDEVLTLHRNLLHMCYYTTVSALHRPQVLPSAPAPWPAKNSGAELQEVSRRKVRQAASEITHLAEELIDLDLVKYLPTTGVTVMLPAVIIHLLDIKSSNELTRELSLEGFGLCMQVMQGLRQSYSAADYATHFLEAAIKKAEIQVTSHKKFGQRRRARYLQNLDHLTPQKPTGASSQHSTPFSGNAITIPASAPPSNAALTPPPDIENINIPDATPLDENELQLKLETFLQSPPSPKHDDRRTPTPHLLPQNAAGTFTIGSNGVLRVREELLFPSEKPVLMTPCLSIPRAPDEENEDLDTLLNLNGQDNDPFFGHYDDAPLMSQKRFDGGTRAFDFVGNSSSWLEEDMSKILDGVDFDIDDVIQVLETEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMC3</accession>
    <name>A0A2T6ZMC3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">13 kDa ribonucleoprotein-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1102266</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMC3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMC3"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="12">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU76637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="126" mass="13625" checksum="892E6B5E1ADB8C2C" modified="2018-07-18" version="1">MAGVNPKAFPLADEALTQTILDIVQQASHYRQLKKGANEATKTLNRGISEFIVLAADTAPLEILLHLPLLCEDKNVPYVFVPSKIALGRACGVSRSVISASVTSNEASELQGQIRSAKEKIERLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMS1</accession>
    <name>A0A2T6ZMS1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000176">
        <property type="protein sequence ID" value="PUU76773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMS1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMS1"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.50">
        <property type="entry name" value="putative glycoside hydrolase family protein from bacillus halodurans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="453" mass="49915" checksum="3A2362639ACABB8B" modified="2018-07-18" version="1">MSPMSPNALTALPIARDLLGPGWIVKAGQRLSAGAAAPRPHPGHTNSSATGPWTLITRETSPIRRDDTTRAENRAAVISHDDQVLLYFAAKTRDHHSSPAPKVQKRFNVIHKGYDNIRREPIPDFRSLFTLASLHLSQPATSIRAMSRINSSYHLKPTALTQSLHHCASNSATSYPSLILVGTPFQSICRVSGTKNILPSWGSTSTFTTNTNAEINHRPAVITNLTDNSSVAQLDRTDSPKWSLNTKGMCNIRVFGHWVRHRFARMLLSTAGPLQTNVSCKKLCHRPSLPLGNRYPIPGVGADAMTIGATMDNEIPWELVNDFLDGSNILGDITNLRKSVIDQPGKTKKRIEEYTKTEPGHGHVSIRPLVQKANNPTHNPYSRLTRESDPKTEASCGRWGNRLVKSLHLELIKDSTLPDHFDLHPLSQADVYGTVGKRCTRNVLTFVNTTAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN52</accession>
    <name>A0A2T6ZN52_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_988618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN52"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN52"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="10">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="910" mass="102828" checksum="B7969E778D69B409" modified="2018-07-18" version="1">MTPGDLVDVPGKQTELALRNPRLPHITQGFIELRLLVSRLVQDSHNRLQGMIGLLAEGGRSDGDKKARIIEHMLERRKQFIKLLVLTMWAKNAPAVSEVIDLKVFLDTRQEIFHKVVWNLYEVRRKMSYARIPNPDLDTAVRVLSTGRANTAMTRRYVPPKKLTSRETLKILRDLNTLLSLRLALHEKLPPYFRDYTIASGRATFTVADEFEADLCIGDGDPTSQLYLVDFRFIFKPSAKTLPAGRIRDEVESRGNIILKQKGLEGIYDYLHEFVMTDKICTLFRQFQMMLSGRWTENLVVDMRKRTLVVQYWSGRVTEGATKSWIEVGIKRGTGGRPSHVGVRWIRDGKTVQDQEVPLDVAVLSAESLIKTVIAMHTKHILTLIRGRLAHSPVFPLSAMVLTTHPTDSFNSSLKLQLTPSRPIKFLIEPITGRFALHPPTMVSTQVELSMNNSPTGTEDLIIRLKFILTQEEVETRARSMGWEVLKMLNIRREELKGFFPNSTKYISYLRRKGWGKEWVVAMVLADTGQTWWVAKVHEAPSQWSMSMALEIPVHGEANATYSFLGNLEKMSSAMITLFVNQSMLVEKGVQHKLQPSKVADPKLVIPDLYIRFSSLIHANWGIDVLRLTFQGLGAEGKCIVTVLGRTKEPMTQLGSTNISAADSDVSFHPQSGSYAIRFNINVGESVIEPLIEKLHRIERLIRFVAVIRRFNLPCLDVSLGRIAFTYDTESNSSAEVSFSGDREMKLHLPPRSPHIRIKGFLEHKLNVSGLETVVMALTVTLPLLLAFEKIEAAIGDKSDGHIFVLSRSVDWFRVYYRRLGVVLDWQLQCRKSVLHWFVRDAVSSNSESEGEIVGGEGRRKADELKGIWSGEVEGDWEPLKSGAAARLREVGALAWKIHELIYAGQGAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNG2</accession>
    <name>A0A2T6ZNG2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1087160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNG2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNG2"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="47"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="373" mass="40617" checksum="B2DF1132FACCABBE" modified="2018-07-18" version="1">MFAARNFLSRATANTLRKPVVNVPRVTAFQSLKIQQKNYSSSGTKDYTVREALNEALAEELERDEKVFIMGEEVAQYNGAYKVTKGLLDRFGEKRVIDSPITEHGFAGLGVGAALAGLNPVVEFMTWNFAMQAIDQIINSGAKTHYMSGGIQPCSITFRGPNGFASGVAAQHSQDYSAWYGSIPGLKVVTPWSAEDAKGLLKAAIRDPNPVVVLENELLYGQAFPMSEEAQGSDFLVPIGKAKIERVGKDVTLVTLSRCVGQALAAAETLKKKYGVEAEVINLRSVKPLDVETITKSVKKTNHLIAIESGFPSFGVASEILALSMEYMFDFLDSPAQRITGAEVPTPYAIGLERLSFPDEDLMVKKTAQLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPJ6</accession>
    <name>A0A2T6ZPJ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1101878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPJ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPJ6"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="716" mass="79582" checksum="2A5BAE5B01E68EBC" modified="2018-07-18" version="1">MPTPLTQPPTLNSTVEITKYLRSRDAPLPSLLSFAEKVLQDNKVFFPRKEEWLLEWLVQRLGEKGDGSAAARCSPKFWGMLLKLLRTSSHTSVAMILKKHSFLQAVGKTLSEGKALPAMVEGDGLEDEDAMDIDSGESYHTPREEPTSVESSVTEESFSAADDKVEASLWRLLPGVYNVLSYLQEQASSGLRSDSGVVAALRGTPEFGAQILGSYFEACMVLLEAGKTVSEEWTQSVLNVWKSCIWGNPNSKKASSPSFLPSNQSFQPPQPTLQLYLEELLLEFIFTPEIIFSSTPGKPSKASSKELMALMEPLKSQTNGRIQLLRLAIRPQLRRSKPDIETVEALVQAIIPLSYARTSPEIFTDLLELLVENGVNLSSETLSLIVDETSGLASGRMQNVKWRLIDLALKLDFDIFLGRSNQRRGDNLIHAIGHAGVDDNNDQILKTLEALIESYAKARNLGGFIEIWAKELQSRAALWESDAVARMVGDRLEKNLSAFQIEKIFKEACGAGSDLKWVLIDVLLRGVRTEATEAKIKKYLPKVVNTAETSASGWRRWRVLLRVIQIDKAAVDQGFIQRVKPSVKEEVDPRETLFFKEFQIALSGGNGVSPPEDALAVALPSTSGARWTGSVKDISNQNLCLALNTGYINNWLESIEHIGSLPAKEEFIDRFFDMALHSKDNEKSLITARGLWLGMLADEEFFELPTLKGEYLIRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQE6</accession>
    <name>A0A2T6ZQE6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQE6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQE6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="790" mass="84742" checksum="AAB67CF84DB1D2DB" modified="2018-07-18" version="1">MDEAYASPDSDGHASLPSPTDTTFDLNDLPFRRRGRQGEHPPIIISSSFLQTEEDSDDDDYIPIPKINKNDADSIPSSPPVMVNHSNVLAPVNANDPNSQRRQSRNVSDSLLAQEGLNENENIDPEENGVDGKMAAGGRPELAHESSDDDGPPEPIVVKKYRARALEHKEDFTRHGAHFLQGTQSSESSSNIPNADDSTLISKIQDASASSKSLIPMPTTGSSRRTSRRRAQGSPEKIAASPLAPPSSEQGTPNTSQHLDYQQWLNSDECYDDSIDGNRHEQDECSTRAGRIRGSQTDMLGESGFVGGDEASFVSGKDIEFTSDEIEILGEEFSRNSPFARKALLKPLRLPEEVVHESTEHELSLVSSTPEELPSTPVSSKFSNKSHESSAIGSDEKTRLDNLHSSTSMGSEKTEHFGKSGSTGRSTGRDTRLAGTELMNPGDDGLNYGSNNSALTRPTNSNRDTAQSPGDHISENVPGSAPQSDPPTAIPPAVKGDSRNSTTQSTSNRSALGLPAQKENSSEPSRSESIDLGPSTMPRSTPPVADTKAPGQPSPSRDSSPISGKAVTQDSDPEALSIRLSRSSSPSLGPAEFYQTGGDDPFPETTARNISSFQADFSQSKIYSAALIATSTPRNKYEPDYLTKLKQSGNVRRVSMNTPPSASPKSISATEVLAHSPRFSSLGSGFDFPTEPLRLSNWDSSDASLEFSPILPIDRSSRSSGDEPPPNTANLTPSPHVVDGVVVKDGKGRARSRSVPIDSAKGNAREKRLFDPGRLGGNVPEEARYISFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRG7</accession>
    <name>A0A2T6ZRG7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_103391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRG7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="16574" checksum="4A3586E0BB823D95" modified="2018-07-18" version="1">MLSSPRSNSSNLPTTSPNSSTSFLSRTSSTLFFPRPVTSPGNAALLVRRSIGIPTPRVNDGYIPSSTIRSSRHTTTLTSAGLTNCGPICSVLVRARASDSRSVRRARAWVTTAAAVDFSSSDNGGGAESVWESCWRRDWPRGFGLAIGSKVGKQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRP6</accession>
    <name>A0A2T6ZRP6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_984133</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZRP6"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1493"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="749"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1499"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1529"/>
            <end position="1546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1568" mass="174312" checksum="5B4D02DFFE003A16" modified="2018-07-18" version="1">MPSTPGSTDPPQLQDSTKVPSGIAGVLRSLGRLNRGPPNPVPATSAAPPSNGNRPNLHGEHFNEEAATSGQVLVNKLKANNSLNDRISAAEALRTIVADYPVSTVTEIWTNAQDLTNEENPPEARQAAFKLLTACVKQYEPSSLDRIKLYRTVALHSRPEDFFHQLQVLIALTNGGRDLSTFQREIGGLLSRWLRTWFKESTIIRQTRKRERTTSEVLSSEEFCLKELFQFTTDIIKFNFKSFEEREVNQLLTDVLSICKKTTSKKDIECSIAFIETLITYGYVPRPALKPCIEVLCGAYATLRDLTDATWNAVSNLCKSYMAHNSILVLREILEAPATNPPGSSNTNTLRGAVWFLEKLLIANETDGLPSVQFTVVMSAFQSALSADSMRLELEISRAIAAILSSKDVVSQIAFDEWPVPLNILVHCSRRATRLMHGPTREGPESDNTPYPYENDGVGQAISQALIQVISLLEVACLNTEFEQTEEVMGFFIRVHPHLPNSGAELVINYYSTEHLCYPSCAEWLDNCRQLLNVFFRTRTRPPSIRISVLHLIKDVYETIRDVCEDEVLHTLAVSVFEDFQYEKDLKVLDALIKIVVDVSSDTSIELFKTLLSLLIEYIGLDGGLPDPPPQGQGSGASARSSISSTTKARSPQQGPQTNIVVRGLVRIFLKNMDTNAVKSVLVYEQLVRISGSADLDPNTRLTAMRLLFRLRADSEHAIFITENPESDHLASVLHRVAKVADEAASIASKGDAESSSSSRSNKSSSVSQTFLFRNPSRSVVEKYDRPKRKPQIWSYPETKALPEKPMHLASPVLVTFYDPPSDFPRREGPSLDPHLCIRMSLWMEKVIPIIQQGCDWEIYSYVLVHLSSQLSNKTAFRNCKAHINMLRSYVCDQLHTNRIPNTDDLPPEVKKADIAVVLINLLTTLISYKQHFAKNETEGIVKAFQLGLHSWQRTAKPCIHALSICCYELPGSTSKFLPGILTKLSQIITSSAVSVHILEFLSALAKLPKLYSNFTEPDFRNIFGIAFRYIQHTKETTAQQLIKATFTNRPGQGQANPTDLNAQTEQPDLPQYVLTLAYNVLTTWFLSLRLSERPKYVSWITRGLVLHDQSNTADEQSQTCIDMLQRFTFSDIDLKPPNKIDTQASGIVTKNWLHCSSILSIQTAPDSGISRVVVRRASGTSYYTLKPDSRDLRSMLQSKWANIPEDLGGLADTAAGVEQRQDRVLPSHFLLQIAGGLGPSETRPILLPEDEKTLRALDVFDRIPVVDFHKIGVVYVGAGQTEEKDILSNAMGSPDYTDFIDGLGDLIALKGTDINTGGLDREKNADGEFAFFWSDRITQIIFHITTMMPMADGDPQCTMKKRHIGNDFVNIIFNNSGLPWRFGTIPSQFNFVSIIITPEARSGFVSSRLLRKGSEDRTFYRVQMVCKEGFSEISPAQEPKIVSDASLPAFVRNLALNASVYSHVYNEGGGEHISNWRHRLRSIAKLRERTPIVYPGSSGNGGPIGGNGGGMSPGQNSIAPGSRRVSAMSAQTLASDHSYRNSAQVNGDADQSETEDLLMSLDFSRFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRQ8</accession>
    <name>A0A2T6ZRQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRQ8"/>
    <dbReference type="OrthoDB" id="5304578at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="19242" checksum="1D667F8E933B435C" modified="2018-07-18" version="1">MTNKPIWTDRFDRNAYSSLGIVLKKLAIMVSFFKTFLLFIFAVSTAYSLPGFPTGLHRRDPDWGNYVYIASIFSGLVGQNIALIALPGNRAVCPTELWNLQTCADSFESECIEERFGFQWCLSHRITTETCGAEWLNMTLGCTGESSAYCVETLETLYDCALEVTVPEVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSD6</accession>
    <name>A0A2T6ZSD6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1025472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000122">
        <property type="protein sequence ID" value="PUU78344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSD6"/>
    <dbReference type="OrthoDB" id="10005335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA ligase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="375" mass="41658" checksum="02231F76C3591A78" modified="2018-07-18" version="1">MANHNQPASKTPAFIKYPNTSQFPGFKMEALKIRSGELRAQGPKLALPAKADFRGTVKIHGANISLVFRDCDNLSDVTLQSRNKIMTLDPGNNDNNGAAEFLAGIPFDRLAQSVFGTAKAKFKTLIIAGEFAGKDIHKGVGIVMLEKFFMVFNICIDDLWRDMGRLSGVALPEYRVFNIMNYKTFKVTINLNADTSAVERQIMEYTQEVANACPVAEALGGSGPGEGIVWTMLVPIRHHRARVLGFKTKAEIFLATAYASRARQPTASTSMTQQTKGVADEFVNYAVGQRRLEQGIEYMVEMGIPLRAENVRSFTRWVTNDTLKEEAEQMKAVKAHPTLICVKIGNFAGDWFSKYLQQVNAEGKHNQKQSRRAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSG0</accession>
    <name>A0A2T6ZSG0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1101371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSG0"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="3">
        <location>
            <begin position="108"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="33544" checksum="DC2AEC1A47D8AE2F" modified="2018-07-18" version="1">MNTSSVTIKEEEDAKEYTIVGRSLRLQTKTLELGEGTTTSIISTTAVTLRKPKGVDRKVRKKNIEKIEGKKGKRIPAGVSGRAWPPLTAKRFGIVQEELAHNPFHLIVSTIFLNRTRGSVAKPLLWRCLQTWPTPEKLSEAPLPELTALLQPLGLHNIRAARLISLANTWITHPPIPFQGTVKYNYPARDTIPFPLLEHDGPKWGVEQNYRWEIGHLPGVGAYALDSWRIFCCDEFRGNGDRDEWRRVVPKDKELRAYCRWRWAKEGIRWREEADDLVEVEGRDCFREGIDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSK2</accession>
    <name>A0A2T6ZSK2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1114943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSK2"/>
    <dbReference type="OrthoDB" id="10439168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="10480" checksum="8092BFDC95FEDD01" modified="2018-07-18" version="1">MTLLTPRMFLAICVTTEPVALYAVSAVSPIAIKSAGLVFGGIFTNCQSTYSVQPKAPRTRSPFLYSGWKLSITSPIVLRSSHPPPLRNQCIVGLGSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTG3</accession>
    <name>A0A2T6ZTG3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1193069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTG3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTG3"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23132:SF23">
        <property type="entry name" value="D-ALANINE--D-ALANINE LIGASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="106"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="372" mass="40246" checksum="9EDFD65131BAE79A" modified="2018-07-18" version="1">MVHSSHQSLEDACAGIAYVVHSLNDPKTNITTPAPHANPAIDTCWSYLGTQPGILAAIAAGTNMIWAITPLLADHPLITTSLPSCIKLIANPPKVVDIVDDKAFTNKLLQHHGFLTPKSWLLEGDPKRAIERLGQLVYDLPCPVILKPVRGSGSEGVQLVNGFVSMLDALANLLNIDSVILVEELLEAEEGTVTLVPDGQGNFMALTIVLPFGHVSGVMPWSGHIPVAKNSRVLSAREEDSWRRAAKIECPKAAGLLKLTSATRIDICRKDENGGKFFLFDINSKPNLTGAGRPGRENQDSLCPLAAKEFGWEYPTFVRKFIETTRHLQEARAIESPGAVVGSFDNFTIWETWSGKGKDGVAGNSDVQEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTZ4</accession>
    <name>A0A2T6ZTZ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1192929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTZ4"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05243">
        <property type="entry name" value="SDR_a5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="244" mass="26419" checksum="7B961E0D5A29695E" modified="2018-07-18" version="1">MVNVLVLGGHGKVAQIISKMLAQKGHQVTSVIRDPSQSPTIESLHKNITPLVSSLEESTPSSIQKEMENINWVVWSAGAGGKGGTQRTKAVDEIAAKKYIDAAAEAPSVDTFLMVSASGSRRTPASWWDKYGVETYQHGWEVIGAYFEAKTIADEHLYEVGREWGLRDICLRPGGLSDDPGTGLVSLGRCKNTGGVTREDVADVAVRLLESDIVGGLWIDMIGGDKKVEEEVARVVRDKITSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUS5</accession>
    <name>A0A2T6ZUS5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1082193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000096">
        <property type="protein sequence ID" value="PUU79258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUS5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="79" mass="8769" checksum="DC28450ADB5D48C9" modified="2018-07-18" version="1">MLPKSSSSSTLPSPTTLLHAGLQTAFLILFLSTRNPGYVVLGLVCAATWGAVQWMDKISRVEAEVERLRRERVRRERGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUT9</accession>
    <name>A0A2T6ZUT9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1125544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUT9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUT9"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="9">
        <location>
            <begin position="200"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="380" mass="41647" checksum="C0432A5B01D6ADD4" modified="2018-07-18" version="1">MAEKEKQDAFRVDIPSNDKGFPPPSPRGPPASSAVSNPLLPILSYCGASILMTVTNKYVLSGYDFNLNFFLCMVQSIVCVVAIAIGKSMGYIKYRDFSMDEARKWFPISVLLILMIYTSSKALQFLSIPVYTIFKNLTIILIAYGEVLWFGGSVTGMALFSFGLMVLSSVVAAWADISAAINNYGHSSDETAAALSTLNAGYIWMLINCLSSASYVLGMRKRIKLTNFKDFDTMFYNNLLSIPVLFFSSLLFEDWSSTNINLNFPEDRRNNIIIAMIFSGLSSIFISYTSAWCVRTTSSTTYSMVGALNKLPLAISGLIFFDAPVTFFSVTAIAIGFFSGLVYALAKVKQSQSKTGVLPTSNPTMSASSQSMRDGFGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUW3</accession>
    <name>A0A2T6ZUW3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_979939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUW3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUW3"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="15"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="785" mass="86887" checksum="CC36099C361B4CF1" modified="2018-07-18" version="1">MFDGEYDPSLAPQRFAPGYIVLSYFVSFLGSLSTLELLQRRTSLRGLYNWYLLLGSSVTMGGVAIWSMHFIGNRSIVLYPKSDRTENLQLAYSSTFTALSFFVPILVLFLAYLLIGTNEDVSYLRLGFGGTFAGLSICGMHYLGQSGIENYRSYYAASYVIGSIFIAVSSTIVALVIFFILRKNFTNNWYKRAFCAVLLSGGVSGMHWCASIGTRYQLRGGSELNRDTRRNATVVITIVLSVFVCVLLIAFAAVTSRARKMESIRAQKVVLASATFDHDGRLMVLPDGTLPIKEVTDSFQEKSFEETLGKSHPVFHWIYQTTRNWKSLSGLIEGMRQHLRHYNINRRSADFVEDYSFVFREMFCIAAQDLADGTHRSLDDLGVLYDEIITTGVSVSNMIPGKNSDYTDVEAGHGKGKILFLIKKVTKAEAANLTETGYRFTDTNNVIDIISRSTQVPKETLIPHLNSMKTYNSMKRMLQPGVHVGCFAVRANVNGGFEILVRSDHLDSLPTVQLPMSVLEARHINFLRENEGVGVGRLIYDMDTPGGGSPSLQALNDPPFVVSLKAALKSLISDIRDPFFADSVLLPQPIAVPCQITPENDSGIAIIIVFKTLMPVHARAVNESPKMDFVPFRFFSLQQRCFPYSPDHDVQTRNTHREFSGKAAAVATQKPLHTPSKKGLRDALRPFSGSGHRFLAPGSSRPSTSSEKKLVTGDLSPSTSLNPFTTGGIMVSQSVSVEHAEVKSDMEMQFMGPSSAITVKDNDQEMPTWADILFKGLVSTSPGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVN7</accession>
    <name>A0A2T6ZVN7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1023490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVN7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVN7"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="9"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="403" mass="44613" checksum="861D172326CA6171" modified="2018-07-18" version="1">MSTPAPPTLQKPKHIKYWLRCLRTCLPSDYTSTDLNRLTLGFFCIAALDLLGCLHTETTEEDRAGWINWIYKNQLPIGGFRGSPATDLGKGADGSEWDPPIVPASFFALAALVSLGDNLERVKKRELLELLPKVQREDGSFGEWLGGDGQIIGGSDMRFVYCAVAIRWILRGREGKGVVEGVKDINVEGVVRFIRSAESYEHGISDKAFGEAHAGLTYCAIGALALLGRLHPTSDGLSTHANILRWLTSRQVPSQAQDELRDEEYESQITNGTEQEITAGAAITYGADGRPLWAGFNGRCNKKTDTCYSFWVCGSLDMMKKLHLVDFSGNRRFLLEKTQHFIGGFAKLPVPGTPPDILHSFMGLASLALMREEGLNRLDPTLCISMQAKERLMSMDWWRDAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVX3</accession>
    <name>A0A2T6ZVX3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVX3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVX3"/>
    <dbReference type="OrthoDB" id="2157641at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041681">
        <property type="entry name" value="PH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15410">
        <property type="entry name" value="PH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="242"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="999" mass="110020" checksum="D1BD875332C95B72" modified="2018-07-18" version="1">MNPYLRSPVKSPGFDLVDENNESAYLQRGATIRTVASSDPISPKRPTFFGESMRHRDSGSHFNDDYSSTGNVYRKETRYARGNGNVDYSLSTRDDWDRPQTSPYSPNKQSFLQDNEEKEMRWPPLATKSILSTRRSVGNVALERERQASIASSFDKPRQGSVVAKEQPIATVQEIEAHHAKLDKQQREARVGKTLEVDTKNLENRERKKAEPSWPSTITPAATRTPTVMLQRDGPGEKAEPLGEDDPDREEPSKEEREIARRVFEGDEEIIAKAKVTAWLGEAGAAGARIRRAYMGLLDWSGINILSSLRIFCGRLVFKGETQQVDRIMDAIAKRWCECNPQHGFKLIDVVFTILYSLLLLNTDLHIADIPHSQKMTRSQFIKNTMSSIRRIVAEAPVESKPAHYSTFPPRSQTPFRPSDDDDSPGVSAAPSATFPLAARERKMSEPRTSLDFVKGAKNSSKASGIGNLSPKGAGDSGEKMDYDMDGGLALVKAPLGGGGGIRAWETQIETVLKDFYASVKASALPLHGVPQEKVVETPHHSSLSVFGSNVLRRSPSTISRAPSELSVSNRNNRDSKLGAKWTAKNRSRPRLYNGSYAGSSRTSLEDRSMWSPSASSTWSKYSLDKTQTSMSVDSLGSAFTHADYAQSIGFANALSHAIIREEAASGTSVDDRESTLLDYDELELAGAPWAKEGMLKHKHHLESMDKKAKNRGWTECFAVIERGWMRLFQFNQSGKSKDAVVGVVGGGNWTESADAIGSFLLRQTIASALPPPGYSKARPNVWALSLPSGAVHFFEVGTAEIVKEFVSTANYWAARLSKEPLTGGVSNVEYGWSDNVLGEIGPGLTSSVSNTGESRPSLQISIRSSLDHGTMVKPRLPGDRVNITDWAPPSQSMVASSLGEADQLRALETYVANIEAELARHNDLRPTMVLTFSPRHPNSSKAMGNWEKKSSYLLREIIKFRTYIECLSSATQLREKLRTGENGAEVGNDNESRGPIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW04</accession>
    <name>A0A2T6ZW04_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1124851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW04"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW04"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12342">
        <property type="entry name" value="RRM_Nab3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034167">
        <property type="entry name" value="Nab3_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="302"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="708"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="169"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="746" mass="82067" checksum="825A9A40E04AC8D9" modified="2018-07-18" version="1">MNKQDTQNSENQADSATNTQTNTDSPVDRIEKRAMLSPISPHPVHVAETASIPVLNNQMDYILDTPEVHAPGPETSNTSVELDYDPETAATTFVEQPKLQQATSSASISEATNDSSPSSSSSPPSVNKAPAPTEIVQNNRSIPTDVDLQALLTSLSPTVSQHPAPLQGTQTPPAAPSTQSPPSQPRSASLPQPPAVVQVAQSQVHAQPTHPLPAPPATFAGSSNTGAVHTSHPAGYPASLPLPPNFNQHRQSAIPGSPTETDDNEEESRPFTADEEDEYERFLTDERDYVTQGQWDRFPAGSRLFIGNLPTEKVTKRDLFRIFHRHGRLAQVSIKQAYGFVQFLDISSCAAALRHEQGSTVRGRKMHLEVSKPQRNTRPAPNADSQRGSRRSRSPDYGRPVSPRGRGNFRGGRGDFNDRSFRRDTRDRDYEYNRRPSPPRHRVRDDWRPSLRSRSRSPPPPRYRGRSRSPPGETLPPRREPKDVPDVQAIVTDELDRNFIWWVEKAFRARNLTYDLLYLHPRMPLDSVIKQQILEGVQAIVFLDSQKQRESSISLQVFNRHGSAEAGYDRYDNIEPAIGAELVIRAKQVVAQPQVSTMPYAYMSQQPFAQLGSLLSSMDPGTLNRLLTGLQAQAQQQGLQQNHMGQQQQPQQPPSLAPDLAALLAQATSNLGQVTAAQPYNAPPQLGVNTGYGSNAQAGLAALFAGQTHSPTQASHPTPTHPTPQQQPPPGQMQNIMETLAKWKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW18</accession>
    <name>A0A2T6ZW18_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1081244</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW18"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW18"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000299">
        <property type="entry name" value="ABC transporter ATP-binding protein/permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="126"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="448"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU79676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="673" mass="74318" checksum="E4F13AE7EDCD7F49" modified="2018-07-18" version="1">MLSPCLLRSIARAAPGRSSLLLLSRDVTRPYPPRLRRDFASTRSLLRNESSGPDKGPSMFARLEKAPAPVINKLIPSASITKTPNLLGEPTLTTQEQRKADWGIIKEMSTYLWPKGNLGVKVRVGLSLGLLVGAKILNVQVPFYFKTIIDSMNVDFLALGGTVWTAAGSVIVAYALARIGSTAFQEIRNAVFANVAQKAIRKVACNVFDHLLHLDLNFHLTRQTGGLSRAIDRGTKGISFLLTSMVFHIFPIFLEISMVCGILTYKFGPNFAAVTAATMLAYTVFTIKTTAWRTKFRKQANAADNKGATVAVDSLINYEAVKYFNNEKYEVGRYDKALKGYENASIKVATSLAFLNLGQNVIFSSALTAMMYLACQGVIDGNLTVGDLVMVNQLVFQLSVPLNFLGSVYRELRQSLLDMETLFNLQKVNIAVKDKPDAKPLKFKGGEIRFENVTFGYHPERPILKNVTFVIPAGKKTAIVGPSGCGKSTILRLLFRFYDVQGGSILIDGQDIRDVTVESLRKSIGVVPQDTPLFNNTIEHNIRYGRIDATAEEVLHVSKRARIHDTISTFPEGYQTMVGERGMMISGGEKQRLAVSRLLLKDPPLLFFDEATSALDTHTEQALLGNISSILKEKERTSVFVAHRLRTIFDSGRALSPTISFPSILPRASRKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW36</accession>
    <name>A0A2T6ZW36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW36"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="163" mass="17456" checksum="8A501416E2A9D3C4" modified="2018-07-18" version="1">MPKGSFDIKVHPRSYALVVHYVPAPLRGAQQLNVTFKLNPNQSSTTFGSGGSAVSHGPRTRGECNNAHTEESPSTASRNAGPPEDYGLRMVGGGNRNEGPWDNPPSARGRIARPGSGDGQTMVELGADQIMTPMTPPRLAYLTRLRFGTHYAREVKTRGTAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW69</accession>
    <name>A0A2T6ZW69_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1080893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW69"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW69"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="240"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="336" mass="37088" checksum="5D1FC9FA6F0D6F83" modified="2018-07-18" version="1">MATYAIRFIAPVVERARRWSQSSIAEERPTLATEASLGSPSTPTTPITRPLVLDSVSEAIDIDSEDTDSERTLVIVDPPTGIPSSTSMDSIPNEPRNAPFPAPIPQPPPSPPAPPSIPPSGGPAISTGQPSAVGPGSNTTKLLVLPEDDGQRELRRKLVEINKLEINERERARRMHLLMTEKYNASRRTADAVEPGPLPLNNAPTTDADGHILLHEENPYKLSPADLARTYYTSSDAAESGVLELGCSHYRRGVKLQCSTCEKWYTCRFCHDEDQDHSLIRRETKNMLCMHCGRAQPAQQDCRHCGVRSSRYYCDKVCIFFLFGILRGILVHPCHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWC8</accession>
    <name>A0A2T6ZWC8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1192332</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWC8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWC8"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000065">
        <property type="entry name" value="N-terminal acetyltransferase complex ARD1 subunit homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="194" mass="21741" checksum="649C8D595808348B" modified="2018-07-18" version="1">MSSLRPFHPLDLLRLNLANLDVLTENYDISFYLSYLAKWPTLMSVMESSQGKIMGYIMGKAEGTAKDWHGHVTAVTVAPDYRRLGLAKTMMDELERVTTSVYNGYFVDLYVRVSNEIAIRMYEGMGYSVYRTVVEYYSSGSGGGGGGGGGGKVGAEGEADEDAYDMRKPMPRDKRRKSVRENGREVRVLPHEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWG9</accession>
    <name>A0A2T6ZWG9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000080">
        <property type="protein sequence ID" value="PUU79851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWG9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWG9"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34826" checksum="FCF46E21CC35D82D" modified="2018-07-18" version="1">MSTTPRVTRRRAKGALERKVPSGQAIGERLKDFIGSRDRGLKDMYGEEGEEQNRKLEGPIKRGEEMARKLIMEMKCTGEVAKDLTVLTLYDVAILIDDSDSMIWEEDGERKETLVELVDHIREICSMANESGTPTMRFMNRAGDMENWTGKRQEYLDHNSYGGLTKIGTELKKILDKFAVGNSNQNKPLLVLIITDGAAEGERKGHLKNVIRNCLNRCEAGKGSDVVAFQFSRIGNDPDGAQLLVELDEDPHIGENIDVLRVGFDLERQFADKWFMLPKILIGAILPDWDKQDDHAGEEKDNDSGSEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWI3</accession>
    <name>A0A2T6ZWI3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1124626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000081">
        <property type="protein sequence ID" value="PUU79833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWI3"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="162" mass="17777" checksum="7A815A5B7E14F006" modified="2018-07-18" version="1">MPTRLHEAGASWLAKQYARWRANGLIDDVGEDFLGLQPSPRIGNFMGAYNGSLKEPDYSIIPDGINGLPRSFPSVVLESGWTSSETKLDCHRHRWHEGSDGNVRVVLLPKIFKPNVDDEIRAILKVSHTIPGAGAQPTLISIKLFPPSNPPAADPTLTMNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXE0</accession>
    <name>A0A2T6ZXE0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1079948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXE0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="7506" checksum="6F1067158DFD0287" modified="2018-07-18" version="1">MPQMIGQTAQCHWSRLERIQIQVPPPAPLADFSRGVQTLALASISICLQSTKIRDSRSLGTRDPLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYF7</accession>
    <name>A0A2T6ZYF7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1079082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYF7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYF7"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015413469" description="Cytochrome b561 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="158"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41611" checksum="D4B550D89A140921" modified="2018-07-18" version="1">MPLHRYLPFILLLLGTGLVPVAAHEHDAEGVPEGKAVSPDPLDSILWIHIFTMIIAFGLILPFGMVLGIIRSRWHVPVQVLGTVLAVLGWLLGHAHKGRQFAPNIHAAFAPSLMSMLALQIGLGIYLRLHLERGWHGVVRWHLVRLHGVVGKVMPVVSWTQMLFGGITAMGFCRADHQGQCLAHFIMGSSFIGYGIIMLIILFAGQAWLKRTGRSQEFWDSLVITIWGFINTFTEHRWGRAWAHNDIQHTSMGVVWWCAGLLGLWLSRGRNKQPKRNLIPGIVIFLTGYAMSAHPQHLMLSTMVHSVFGYTLMAAGLARIVEIAFVLRDKPALDGEPSSFQHMTPFLLFASGFSGFRSPGDGKLGTMLAFEYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYP7</accession>
    <name>A0A2T6ZYP7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SMG7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1191800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYP7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYP7"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="180"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="686" mass="77163" checksum="76395ED47612C61A" modified="2018-07-18" version="1">MAQIEELWRSALRWEKELASILSDRPNARSVDHAIFQLREAYVSIVFLDCRLALERDIEGRIWGKHHKIIERYRGILSQFKETHGRKRPVELRKLQNSFTNFIKQATRFYRSLIQRLISHFGLAELEWVPSVDFPTTGPPRYEAEIKRLIISSCHRTLVFLGDLSRYREVSQNPKNWGPATGYYTLAKKLVPTSGSPHNQLAVIALNEGSNFSATYHLYRALSVAEPFPEAGDNLGVGFRKVLKAYKAGNLTANLARKEEQVIHELVALFVRLHAKCFVGKEFSDYEAIESEMLTQLALDLKERTMSNGMLTKFVLINIAAQFYAANRTPKANFSRSHSYFLRLNVATFTTLHQVFQPELERLFDDKTENEIEPISAVGRRMLPALRLYSTWLRINHRTLTGQLADTSLSMLIRQLWQTYANTLSLLGATFPIDRLPKLSYLLEEDDDTIGYLPFSQANGSTAYNWDDESKEKGHPNDEMLARILSLLEDGRLLCLEENIPITISNTTILYQEHGIPSSTPSTDASSFYPSQAHSSTPAPPYNRTGTSVPPHLGNEFPRSMDIRRPSESVLAQGGDSIVGSVAGSETMMNKMVDLLVGPRDVARCEEEEILFEGKRKRRKQGKMPGWNQDTTARDSLDSAATGEARTEGLLADLAGPASSEDSYTARDLAALVQNFTATHQSGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYR3</accession>
    <name>A0A2T6ZYR3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_974498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYR3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYR3"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="602" mass="67589" checksum="361DCD07D9E2079C" modified="2018-07-18" version="1">MTRSGAGNRFRTRKLSTKQSLAVLRENQIDSVDDDAQRNIPQIETGVERGEEIEHHLQAAISASQAAAVGAKVTQIFIPTPNTTEITVTNYETLYPKRFSQPASYIRFSSTVEDCSGTGYCMSAEDEKFLEKMNATKRPGGQQCKVEEFERIMDLFESIALEKQPYMSIDMSTVMLYDEMAAHFGDALSSELVKIAAVVYSHWKEQRVARGGNPIIPILKFEQGQDKDDGDPYVCFRRREVRQVRKTRRTDAQSTEKLKKLRQEFDSARNLVRDVLNRECMRKTIFQVEYGIFESRRQIIGVKRKNGIRGDDEDLINHKPKKRPVDQSAPPIIRVPIRHDGKPPETELRQLVTVKAEKEKQRADKFQALKSSRRVPKHGFIDLTDQVFSDSTVVPRGPDTNFCGVQTYYLPSPPPSCEGNGAGLFDLPEEPSVSAPIPVLQVSSKSPPSRDVPAFRRRRGRGGRIIVDRRGHGIPRDDDLDDIILDRMKHSEEDGDYSPVFVRSSNSDSHIQYRARMLSPPPEPPVNPPQHMRRPVLPSLGGMQPGAPAVFLATAAAAQQAMGLAGYKLGQHPGPQQPQQQQFNASLPPLANRAPVHAQVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYS0</accession>
    <name>A0A2T6ZYS0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_974317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYS0"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000002">
        <property type="entry name" value="Ras-related GTP-binding protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="329" mass="37060" checksum="B09A595640FE3DBE" modified="2018-07-18" version="1">MEERKGRKKKVLLMGKSGSGKSSMRSIVFSNYVAKDTRRLGATIDVEHSHVRFLGNLTLNLWDCGGQDAFMENYLATQRDHIFRNVEVLIYVFDIESREFDRDLITYSSCIEALRDNSSNARIFCLVHKMDLVQTELRERLFNERRDVLVSRSLGLAITCFQTSIWDETLYKAWAGIVYTLIPNLPQLETHLHRFASIADAEEVILFERTTFLVISHVTRAPTPNPYPDRFEKISNIVKQFKQSCSKMASNFTAFELRAAGFSAFIDVLTPNTYILVVMPAGAAESATTLMNIAVARKHFEKLERDSSVRGGERGGGGGAGEKDGIIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ46</accession>
    <name>A0A2T6ZZ46_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PH domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1100074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ46"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29342" checksum="03E1065AB49D4374" modified="2018-07-18" version="1">MPPQSRTIPDVNHTVLSRYLPRLQKILSLASYAVLYTYNHESGIWQKSNTEGSLFICSLSPTQQQQQEEYTIILLNRRGLQNFTYALTDPGNIEYAEGGDYVMLQGEEEKIVYGIWVYAEPGTSSEGDKTKVAEWVKVCAGWYVEGMARTRKEQGREQQQAVGGGVGLAGGRSISLTELFQSSSPVTTTTLQSQQQQQQQQRHHPQHSTQTYIPAQHQQEGYFHHQPPPPPPPPQSQEATGGDSPMRLFASSRHTGRATTSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ58</accession>
    <name>A0A2T6ZZ58_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_698058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ58"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ58"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="37"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU80740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="280" mass="32669" checksum="CD3AB7147CA37790" modified="2018-07-18" version="1">MKADKQLKQTDGSRRSRINNPKLIDANRAGTKDSQECVLILTEGDSARSLAVAGISAIAGRDRFGVFPLRGKLLNVRDASHDQIMKNVEIQNVKKILGLQHKKVYESRKELKYGHLMIMRDQDYGGSHIKGLLINFFETQFPSLLKLPNFLSEFITPIVKVFKGGVKKPTKEISFFTMPKYEYWEENNTEKGWEHKYYKSLETRGERDAKLYFSDLEKHVKEFHVMEEEGRRLIELAFSKKKADERKEWLRLYKPGTYLDDIRIGSKRDFWGFAYSTQFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ60</accession>
    <name>A0A2T6ZZ60_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1123107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ60"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="24577" checksum="4298E993C7CDAF60" modified="2018-07-18" version="1">MPRPGPVSGPGRGILPGTHVFRGHGGPVTNANLEEREQPVLTMLNGIWYKEMDRHSQHYERAEAWLQPAGSLLISFGTEKLNDRLKFAPQYNFQISGPNDALVTRAINGARGYRVNSESRKCTCHYFFDNDIPFVHAIAVIYILWNAQLTSCQAIAEPKPTRRATKSTYRLSILSIPLHSELKRILAISKVWMWKWGRWGELVWDWIWRWNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ91</accession>
    <name>A0A2T6ZZ91_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1044085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000056">
        <property type="protein sequence ID" value="PUU80812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ91"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="10299" checksum="1225AAB4D0AD685C" modified="2018-07-18" version="1">MCLIQRFRVRRGLPIAISLFLLLMDALKPWSLRELENRWFPDSAGVQPQNLHPFNCSQVSYLPEVYHRYPTFSPCFLQHQHCALLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZA1</accession>
    <name>A0A2T6ZZA1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1078650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZA1"/>
    <dbReference type="OrthoDB" id="3443409at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="54" mass="6034" checksum="4439FE5AD0B69023" modified="2018-07-18" version="1">MCSLLTTYFVYADCKERKKHYVDQEIGVGNSCPQGPHNNFVIVPGSCETCSYPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZE0</accession>
    <name>A0A2T6ZZE0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZE0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZE0"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28739" checksum="FEAB9615239F4235" modified="2018-07-18" version="1">MLLVFAPVGIAAYCARVDPWANYSDSNAVKLIIPILALVKDEIVAVQASLVGTILGKLLLILGTSFIAGGYNHIEQSFNTSVAQTSSSILTLAVELGHNTAVILLFVYASYLLFQLKTHSDIASGPAKVEEDELVLMMRTAAILLVAWMALMVICSECLLDSIDHLWVFVGLILLQIEGNAVKHATAVTVAVKDKMDHSIDLAVGSSLETDSLVIALIVFQVMILIVSVLLYGKSNYLAGNLLAALYVIFGLACFLYPEEGPLADVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZK4</accession>
    <name>A0A2T6ZZK4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1191536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZK4"/>
    <dbReference type="OrthoDB" id="5397552at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27370" checksum="F23904F51C205A9A" modified="2018-07-18" version="1">MEALDNRQKLSEIVTAVANLQRSLGENFILVGGASLVCQGSERVTSDVDLLLPGASIPRLAYTLTQSSVTRRAGVIYSIVEESEFPVDILEKVIGEKTYEDLEPFTITIFDEIKTLDFPIALGIKIRCWFLRDEETPLGIQKQESDLVDIGFICERMEQAGKVVDDMVAKAIPISCYNMQLVKDCLKDTGSLALFLSVGGHKFQVPWEEDSEEQRGYYMEMMADEAEAACQQGVTEEGFVRPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZV6</accession>
    <name>A0A2T6ZZV6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1113619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZV6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZV6"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000329">
        <property type="entry name" value="splicing factor U2AF-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="140"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="401" mass="44822" checksum="AB2D60D3E63738B1" modified="2018-07-18" version="1">MEPPLPTEVGGGEGGSSFPTTREEFEADPRVSWSRRTGKWALEADDGTEFEYDEGIKRWVPVLDETLAEQQRAAYAVAGVDESEPAAPVNKKRKKVYTSNEGNGDPTHLKKPKNTKDSSSLTDPTTTTASSSAAPARKNTAVYITNLPPDTTEEEVKEVFSKCGVIAEEIDRGKPRIKLYRNEDGSVKGDALVVYFRPESVNLAVQMLDDSDFRFGVNEGGRIKVQPADFSYKAQQDAPVRKNARDKKKVIAKTQKLNNKLADWDDDDPSKIADTTSKYDKVVILRHMFTLKQLEEDPTAILDLKEDIREECEKLGDVTNVVLYDKEEDGIVSVRFGNAESAKACVGVMHGRFFDGQKVEAYIFDGLEKFKKTSTKRTAEEEEAEQERLEKFGNWLEESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A066</accession>
    <name>A0A2T7A066_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_637734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A066"/>
    <dbReference type="STRING" id="42251.A0A2T7A066"/>
    <dbReference type="OrthoDB" id="2104723at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF2">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="34898" checksum="8308D95C68348D0D" modified="2018-07-18" version="1">MTIMEDKRVLTIASHVVSGYVGNSFSNHSGYRRLKGFRTTAEQISDLYDGLKGCGLDDFDMLLTGYIPSEECVEAVGRIARDMKEREGGCFWLLDPVMGDQDRLYVSEGVPPVYKSLVGMADMIVPNQFEAELLSGVKVDSLPSLSHAISELHRVYNVPHIVITSVTFTNGDKKMLCAGSSATSSGVPRKFVFNVEIIDGFFSGTGDMFAALTLARFREEAEKGALEAAQSWRCDDAVSPLELPLCKAIGRVLGSMHLVLVQTQLARDRILGGKMKEEEVEVGGEEFVRLTKASELRLVQCQSELKDPEVGYEAAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0C3</accession>
    <name>A0A2T7A0C3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0C3"/>
    <dbReference type="STRING" id="42251.A0A2T7A0C3"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="995" mass="107062" checksum="95252382339F0249" modified="2018-07-18" version="1">MPSPTFRTNHAAGEYTPQVSPLDDLINRGRMLQKQMVSERAGSAGLSPLTVHRSLRRVGSNPGTLGTPGTLARSRSVGRTPEVEKGGRWGNAALAAPSIATTAAPTLEVMGDRRLATPALEERPTSSYPRFSTVSEATSDDGRSDRDSIMSGESARDSNFTLISGFLNPVRNPPNLQQIQGRHEVREQDVERSSLKPVIVGHIKDERQRREADRVGPGPGGVGARGGPHVDNKPRGAIAQRRAPEDRQRGPSGPLGPAGPSGPEGRRRNPEERQRRPPGPPGPPGPPGPSGPSGPSGPSGPPGPPGPPGPPGPPGPGGRQRGPDGRQHSQRQRGPLGPQGPDGRQRGPDERQRGRGQDQRDMAGQDNASTYARSRSQPPPRNRRPGRQPLEAEQQFPMRKDSKDLTVVVPPGPSGPPKQPVQSSQPTPAYIPYRQDSKSSPLGYSAPSRQGSAESEKFPPPIRQASGERLYPHRNDSRGSDRRFYPRSPRREGSNDSVTKYLPYRQGSGDIEFQRPSRTDSLESVHRPYSPQLAPRTASPAQAPSSIFPMISDFRASSPDSIGAESSLTFGPPSAPLARNPSIPYDGTDGHEVTRSASQSSFRSDAPSVYSVGGTLLQKPSYNFSRPSPSLDIPQRLSPEQSPMFSDEQSLPTPVSISGDPTEEAEGPVPTYIYSKFILPRGREPERNSVIFQDAGGYPGQTVYQPTHSSSTTVSSTTTVNRPPSPSSPPRAFLQPAPPPRDPRRSPQTGHTPSLSPRIGLLTPTAETRGRSATVTSPCSPRTPSSRSNSSQPPSATMLPDEHVQLGIDLHESGSLQESTYHLRLAANAGHPTGMLLFALACRHGWGMKANQKEGVMWLKKVTELASSEVADDEQAGGSVDYIEKKGRRAQFALSIYELGVSHMNGWGTEKDQGLALRCFEIAGRWGDPDALSEAGFCYANSVGCKKDLKKSAKFYRMAEAKGVNMVGNSWIWKDKYLDEEEKAAKKSGSGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A117</accession>
    <name>A0A2T7A117_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1077220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A117"/>
    <dbReference type="STRING" id="42251.A0A2T7A117"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015738289" description="Chitin-binding type-4 domain-containing protein" evidence="13">
        <location>
            <begin position="17"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU81429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="34764" checksum="8808F3E0F0816F9C" modified="2018-07-18" version="1">MYTSAILLGVLPIAFAHMGLHDPSAFGFNGDGYTLVEPLSGKSFDQWWFHGNLNQKPPGPPMSLPAGGTVTVEIACNKDFTSYGKKGDGKNACPTDTPSYHAGDPIDPKQLLGCGLAIAYKDDATKVQPEDFTIFSVNDQCVNGLKQSFSVPAQLPACPNGKCICAWFWQGQDSDNEMYMTGFECKVDGATGTASIGKPLPPKYCPNGSGCVSGPKQPMYWANDRSNIQFSGEYYQKPSYNAKWGFKNGAQDDIFGGTSGSNPSPANPAPPTTFLTVTSKPAATPTSSPSPDSVRGGTCDWPGHCAGANCESDDDCSDDLTCQRGKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A142</accession>
    <name>A0A2T7A142_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1122202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A142"/>
    <dbReference type="STRING" id="42251.A0A2T7A142"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="121"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="617" mass="68427" checksum="7E434C43F5ABCAD4" modified="2018-07-18" version="1">MATLTMADPHRADFLHSMYGYSPTVALPPPVLLTSAWWDEQKIQETATPRFIRQALHSRSSRKRLDEQLQFGEGLTESTYLDWILEHTRKFFLILVELNCADMIFEIIDGSWDDGDLPLSLQTVERLGLGSAGVEKKFAKKQYAYLVRELVPGETMEYSEEEVVPLEVISRRVSTAPGGTIRGGLVEKVYFPRQREVCYSRRRVPLSQEGDEDSGVGGNKMSPASFLAEISRLGSIDHAHIVSIYASYMHDDYGYLILSPCIDLTLKSFLYSPPPAWKSQPKDKRRRIIFNWLHCLADALAYLHEKGISHGGVKPSSFIIDAATYKIFFADTGDSNRLDSSSTNTTVPSSFISRQFSASTDVEGYEYGAPEHWQRILAVHESPSLPTNTVFSGRSYRKASTQSTNSNSSEETPSPSTNISVGHWSSSTPTHPTTSDMFSLGCIYLDILSFKQKRKTTAFISHRSAKNRRPRESAPPDASFHANLGQVDSWIGGLLKETKKKSDEAIVEALSITRRMLSRDPGARPGARRVADECYAIVRGVCEGVEMPCCGVHNIINASAEGEVFGGWGIESLVLKTQTSRSTSSAGSEELWSKRSTTVSMASGSSGSVRSRRRMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A170</accession>
    <name>A0A2T7A170_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_604223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A170"/>
    <dbReference type="OrthoDB" id="2503759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="250"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="39044" checksum="BC986B1CCC07B63B" modified="2018-07-18" version="1">MNSQSSTCRYHSPRCHTPDTNDEFEEPPPGLESPGSGTLPPGNPQMLGLSQVLSYLQILGNPQVPGNPQTSSNPQIPHNPQILGNQQIPGQQQIPSNSQMTLYPQIASNLQMSGYPQMPGYPQMASYPQMPGNTQMPGNPQAPGTPQMHSNPQMPSTPQMTYPQMPSNLQTPGYPQMPGYPLVPSYRHPELHPYPLVQHQIYGLSLPPDSIPFCPHTTSLNPNVQSPGMGNVGSLPTAPPKVSPGMEIIIALMGVTGAGKSHFIREVTGNSAVEVSGDLYPCTDKVQSYSFEYAGARITLVDTPGFNGMNRSDTKVLRMIANWASEAYRNDQLLSGIIYLHPITHTRMEGSILKNLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1R7</accession>
    <name>A0A2T7A1R7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1099613</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1R7"/>
    <dbReference type="STRING" id="42251.A0A2T7A1R7"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="152"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="327" mass="35751" checksum="3E3B3BCD2461B01A" modified="2018-07-18" version="1">MSRFFGKKKGAATDDDDAARSNLFGNRTAQNPPSNPNGGGNPYAQQGSYNPGYGGAPPADSGSRGGGGYGGSYAAQNPYAPHNGGDDGRSREDYGGYGYNSEEEDVEAVKSSIKFTKDQSVRSTRNALNAAQSAEESGLRILNNLSTQGARLHNTEKNLDVASSQNRVAEDKARELKNLNRSMFVPNVGNPLRSKSRAEAEEAKIIARHQAEREERDRTREFGYESKNVVGRALNTTTGRVESKGKSSLAERSRYQFEADSEDDALEDEIDSNLDQLGAITGRLKGMAMATSKEVDRQNQQIDKIMKKSDRVDDQIALNHNRIRKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A252</accession>
    <name>A0A2T7A252_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1106184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A252"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="461" mass="52230" checksum="F4EB9306B4865F17" modified="2018-07-18" version="1">MMSPPTIPQISYTLGQLAFYYKYSPPTTAWSQCLSPLESKSDLRILNFLSLLLTTGGPADRAAVSFSYTKDMGLQLFYSKCHPCSNEETYYVTQIFAIATNPQLPLPVKHNDLFHLAVMNCKAKISSRLHKASSCLKDLSIRKDFGILDRNSELEHESNSKPTPCDEYIRRYVDPEMFPNGSSLPQFLKKWFYSFLDTFGPDSSFVYPFQAINITRTLHVCYFLVVHPETRKILDPDLYYRLQKLAEYRPAIAAVIGWMGRFDSEALSTLKVTEIVPSPTSSVDVSGNFLQILDKYARYTGSVGVTDKDLCTSYGRMRSFPVSLENKITLHSHSGCFLALALAKRFFATTIPIVLNIGCAKPMCWICLEYLATIHHCYPHITICTTPNNRRINSTWMIPPGTPCEVATTMYERLGTALNSVITTCGSNSERWHNPLSETEFADSMQYWISICKDRRLAMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2E3</accession>
    <name>A0A2T7A2E3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2E3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18975" checksum="EF10CA9EE543E188" modified="2018-07-18" version="1">MSRNLGASSFEAAHDFQALSEFNSDIPPETQAPAIRKWNSEASAKKDPYYGEHRIGFKNEVEPKSHVIECSELVSFTTAVAVSRSASFLPSPSTCNLDSARASSKQLGSTTYRTTSTILSLRKSASLLGLPPLTSGMLVLFSTADTYYLQWLHARETHFEGFRQSPQLHTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2L9</accession>
    <name>A0A2T7A2L9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1076100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2L9"/>
    <dbReference type="STRING" id="42251.A0A2T7A2L9"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07230">
        <property type="entry name" value="Pat_TGL4-5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="193"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="764" mass="83454" checksum="039B5670CC788A03" modified="2018-07-18" version="1">MSFIHSRRYFTSEEIPTSTSGSIITPILKVLQDPASLLSSAFVLDEHTKRHQLASARLKNATTYADWHKAAQELDALEGNQAWKSEVESPDYDYALVAARLKQLDEARTSCDVNRMLFLIRTTLSRNLGDMGNIRLYKHSHTGTKRLIEEYISSCVLTLNALLAIPSTLGAPSGREILDSLLKTRQAFGRTALLLSGGATFGMNHVGVLKALLEQSLLPRIISGASAGSIVAAVLCTRTDDEIPTILEEFPYGNLDVFEDGKKPESVLQRVTRFLKIGAWIDIKYLTRVMRELLGDITFQEAYNRTRRILNICVSSASIYELPRLLNYVSAPNVLIWSAVAASCSVPFLFTSTSLLAKDPQTGLPTPWDPSPQRWIDGSVDNDLPMSRLSEMFNVNHFIVSQVNPHVVPFLAKDPPSSPSSSFTAPTPEPASTWRTKILALAHTETLHRLNILSELGIFPTSMTKLRAVLSQKYSGDINIFPETPYADLPRMLKNPTTEFVCTAMERGERATWPRLTRVRNHLLVELELDRVIHVLRARVVFEPGRGDGTEAATGVGAGGGGRRARGMCMMRSPRGFGAAGAACTSFNAGSASTKLVSTCGNGSVRKTPRRRHQTTGTEGIRPKFINQHQLPLPPHHHHRRAKTATATTPTTPRASTAGDYFTLQPDHSAFSTSDEEEGEGVEPVANSARKRFASWNALVISIPTATSTSDGGRALSSRRGRELVRMTRVAGEFDAGVGAGAGNGVKVGIGRAKSAEELRGFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2Q6</accession>
    <name>A0A2T7A2Q6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU82022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2Q6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="142" mass="15838" checksum="6E441CBA1C6D5FF7" modified="2018-07-18" version="1">MSPYEHFPWRYRILRALSMQSRSPFTTAFYAILSVDHQKDVPIHAFPMALQNSGGVRHAIMKPFYDGVLHYPICPPPKGHPNTSIFHGATESSEGGVHSGGVRQAIMKPFYDGVLHHSGCSPSNGCLHRRSFHRAITLRGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A328</accession>
    <name>A0A2T7A328_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative DUF221 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1075816</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A328"/>
    <dbReference type="STRING" id="42251.A0A2T7A328"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="638"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="34"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="221"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="425"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="796"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU82095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="895" mass="99236" checksum="AB2759309008D885" modified="2018-07-18" version="1">MEAIHALLKRDNAANPNNDPNIASARQEGTSVSAFLSTLVVNLLIFVVLITIFLLLRRSNKRIYAPRTYVGVVEKWRKLHATGDADEIEGVSGFSSLFGWIGSVWKIPDETVLRTSGLDGYFFLRYLRKAQMICFVGCCLTFPILFPLNATGQGGQNGLDLLSFSNLKDTKEISYRLYAHVLVGYIFFGFILFTIYRELIYYTTLRQAYMLSPIYSSRISARTLLITTIPKAYLTETALRRVFENVKRIWINTNTEKLEELVEERDKIAYQLEAAEVALIKAADAARRKGNLGQDPPEDEDEGEAEGESGSVAARWLDRKKRPSHKLKPIIGEKVDTIDWCRGKLAELIPEIEDLQAIQKNGEGTKLNSAFIEFTSQSAAQVALQVLAHNQPLHMAPRYIGVTPGEIIWSNLKLQWWERLVKVATTTAAVCALVIFWSIPVAVVGSISNINYLTEKVHFLRFINDIPPVVLGVITGLLPVVMLAVLMALLPIVLRLLSRIAGEPSNSNVELRVQNMYFAFQVIQVFLVTTMTSAASSVGAQIADNPASATSILAENIPKASNFYISFMILQGLAISSGALIQIVGLILYKLLGMLLDNTPRKQWRRWSGLSGLGWGTVFPVYTNITVIAITYSMIAPLVLGFAVVGLGLLYSAYRYNFLFVYNVDIDTKGLVYPRALYQTLTGVYLAEVCMIGLFAIRKAAGPLVLQVVFLIFTILFQLSLSSAVEPLLKFLPKNLEKEEEGLLSVEDGTSGADDAYEPEGAAGPRNEKNNASKGANHPESAEGVQTKPGGFLARFMHPETYYSYARMRKVIPQDYPEIAYSPEAEKEAYLNPAVSSRPPILWIPRDEGGVSRQEVAHTSGVIGISDGGAIINEKSKVCWVEGEMPPDWEEKPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3E5</accession>
    <name>A0A2T7A3E5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 12 kDa subunit mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_464955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3E5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3E5"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039993">
        <property type="entry name" value="NDUFB10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13094">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE PDSW SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11763" checksum="321D5EE08BF11E3B" modified="2018-07-18" version="1">MPTPESAAFLAKKPTVPPTFDGVDYEDNTALKAAQDAIIREQWVHTMMARLVRQELSKCYRREGVNHLAKCGVLRERYMELLKDSKIKGYIFEQRNYMPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3I8</accession>
    <name>A0A2T7A3I8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3I8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="8591" checksum="191E3D8408B8D876" modified="2018-07-18" version="1" fragment="single">MTKVRSVRLACFLRSFPPSTIILLFSVYRHLTYCTISFPFAPPFFPRWLQSTERTRPADSRGFNCESGKKEGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3P6</accession>
    <name>A0A2T7A3P6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_427434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3P6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015586776" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22345" checksum="4FA346F361C0754E" modified="2018-07-18" version="1">MMPVVVVCFGYHCFVCLFTCFFTEGTRKKSRFAICYSSSHICAPTIQGWNVCTRVRVLGQTGQYACVCMSRFQLDKHPAHPSTAGPLPLSLSLSYRTRPVSLPVWQSTVRQGYNITSLILRKQKNKEKKSNNAHPALRPYERWRGIAIAISIMPIMPITISTSTRVIHNLQSLAQYTKWLLSASATHHREQYNTIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Q5</accession>
    <name>A0A2T7A3Q5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1075104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Q5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Q5"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015662814" evidence="2">
        <location>
            <begin position="20"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="809" mass="92720" checksum="3CFF8252ABBA7F32" modified="2018-07-18" version="1">MLLPKPILLIPPLLGLCTAAEQFPLTGHTETNTTLEEDTSTFIFTSLQGLLSQWANVYAPTGFSVVPGVIHPQTLLYHARRDGDAPPNREWLAFDSEMSYGIFAHRTKQLFLNTYSTTKESKILYFDGGSAVLVSGGTDSQDVILHGKVYTWDAQLQDDSGDDDDGKRGPGGYDYTRAKELCEWGGKFGVEGFVRMNSGFEVLWCDFGVGLELVSRLNVTREEPKGEDKKPGHGHPPCHGHPPGHGHRKWRWWWPPSWWPPRWRHPHCPGHGRPGHPKPPHHPKPPHHPKPPTYPTPPKHPKLSKFPEPTRHPEPPKLPEPPKFPEPPKRPEPPKIPEPPRNEHNDMPDGHQPCGEHDGYPEHPPHERIRHDDCSEHLDDRRKHKWRPSWWPGNGRSPKRGHEPPERNHPHQPPDHPPPRGDHPPGRGHHGPPRHHPHHGPPGCGHHHPPGRGHCGGRPEFHLHRREWPPYERGHHHPPRWGRPPPKHGKPGEPGDGHPGHPYHPYYPPSRHQLSKYANEVFWEWMRSASWNFGTSEARVKLDTCRMTTFYSVPIPGLTPPGTLNAKRSHRLLNITHSQAEEIKKQIEDNLSNKDLYCSGTDWQEVSNSIARRYLTRLLELRTLLNIPRFHVPPSKLYRKLRALSHALIMPFYEIGSNVEEAETRCVKEYTGRLNTTHLGVSEKLLADSVEGVLSRICKLSFGIYTEIVEHPTLTTAQDDEDESDDEHGSHHHHIFKWREDLEALMLWLDWSGWYKCERTCSSNEICAIPLWPVFGTSWDRVPSRQLLEYPRCVSVEYLERCGVFRGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A471</accession>
    <name>A0A2T7A471_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L13e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1074665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A471"/>
    <dbReference type="STRING" id="42251.A0A2T7A471"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="24482" checksum="C869FA538CB9DAE6" modified="2018-07-18" version="1">MAIKHNNQIPNNHFRKQWQTRVRTHFDQPGRKHRRRNARLAKVAAVAPRPIDLIRPIVRCPTIKYNRRVRAGRGFTLEELKEAKIPRKFALSIGIPVDHRRQNTSVESLQANVARLNEYRSKLILFPRRANKAKSGDSSKEEVKAATQTRSVAATFPVNPGPGKIEFAERTITDAEKERNAFRELRVARADARNAGAREKRQKAKEDEAAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A472</accession>
    <name>A0A2T7A472_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_387604</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A472"/>
    <dbReference type="STRING" id="42251.A0A2T7A472"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Prevents secretion from ER" evidence="6">
        <location>
            <begin position="105"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU82543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="11371" checksum="E94FBE3D6EFB9FB5" modified="2018-07-18" version="1">MATRRSLKGEKITEKEEIATIVPGVSPKNDTKGPAVPGSVVAKLLLFTLAMVVAPLGSYFLTVDTVFSGNTTFAGATAAVVANVVLITYVLVAMAEDTREQEEAKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4A6</accession>
    <name>A0A2T7A4A6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_908856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4A6"/>
    <dbReference type="OrthoDB" id="4230268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8743" checksum="B334BE9ECD4A5C91" modified="2018-07-18" version="1" fragment="single">GEFFLLMFLIRHPDIAHKVARPINKDRALAQEPARLESFFNRLSEVRSQFKIQDINIWNSDKKGFAIGQAIGGKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5H9</accession>
    <name>A0A2T7A5H9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cora-like Mg2+ transporter protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5H9"/>
    <dbReference type="STRING" id="42251.A0A2T7A5H9"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="71589" checksum="2371A82B8D807EC7" modified="2018-07-18" version="1">MDHLSTNFAASLDTHSAPGPSAGSIHQSSQALPQSLTFAKESLDHFHGWKTIHGKQGFYDEEGFLYPSRNLTSEKLKDRKEDDVVIFNYSLSRTDETPPAEGSRPSPASFGEDDDIFFQVPKDTFIGSEQFNQVINPAKEPRPIQTWARLAIMDFPQCYDAYDGNLLNSMAKELHLPNPATLADAHSKRVLTLPGRGRFRTGFSLRIPTKNSSELAKSGFSEDRIALFISFPYFGKSSSSIPLGPESESVELLDFKHLGVDVPDHSAVVSGENNSLEEILVHQARYMIFDNYTIATFRSKEDNTKDQVPLHRFQERIGAFRATVQMIANRTDSELWTFEKLQASLCTLEEDIDRMISDAEIYEDDQGMKRKQKRVQDLLTSLNRLSASLFAAIGVVERQIAVLQDLHGLFLTSSRKKNKDYEKGYSLRQSPFCKNIAPIPILSENSEQIWPNTLEAIDVVVQERKCFVKKVKALVKNMGVRRKILSAFLKSDQAKASPSERTAQETAWAVKRTEDAIRETVGSIVRSEETVKQIGSQLIQQGQAVDGFAILAIAFLPLNFSASYFGMQTMKEFSGNSAKMTLSQFWLTTGPMVAGILLLTAIIAVWGRSAAAIFSYYVRLKSFQSLRKWMRGEKDLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A625</accession>
    <name>A0A2T7A625_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A625"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="20300" checksum="3D11E9674B2F105A" modified="2018-07-18" version="1">MIMQGLFPFQRPCLRFAEPFEVEFIIYRGVWFISSCSSEPINFSGPTSNTIVYPPSLLFVGHFSLPYLLRARHTPIPRQTHHHNHHHHHHHHHHHHHHHHHIVNNHRQTPFINGIHALTVTKECQNREAKYRCRTALCSSTCDAFRSWKAELMVGQTKSTPITGTGTAFTDTIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Y3</accession>
    <name>A0A2T7A6Y3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rad9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Y3"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Y3"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="36136" checksum="AFC9EC68326BE68B" modified="2018-07-18" version="1" fragment="single">MEHFGPKAEQLDISSENGRAAFTSFTEKLVDGKEILKQPLQTSVSFDTADFDTFGAEDGVHVAVSLKDFKAIVVHADSLHASVTAYYSDAGRPLQVTYEQEGMNCEFTLMTLGDNRAFTMTRVEHQPPAPPPPPKAVPPLSQTDTPSQQQGIMSAPGSLRSQFAGSFRSQRTTEDRVMQPVEDQSSGSLYRSRLNISGTTSSRSGSAFTQQEPELPPVPASAVAPEGLFLPYSSSDESDDDDLGKVAWDEPFLKWDTNLNSDDRPRPVVRDQSPPPPPPRVPPPVVSRKRALEPSGDTTQSEEGEDEEEMNAKTVIEAVGPTQDVSQARGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A709</accession>
    <name>A0A2T7A709_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1072290</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000010">
        <property type="protein sequence ID" value="PUU83536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A709"/>
    <dbReference type="STRING" id="42251.A0A2T7A709"/>
    <dbReference type="OrthoDB" id="2154311at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU83536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="421" mass="47873" checksum="901E80A4415BC93B" modified="2018-07-18" version="1">MRHHDHRFEWTRSEFRAWARDAAEKFGYKVKFTGVGSFGYGMMIENVDAAVVEEYLAKDMSGRVDEPEDADYFPQELVEGSLAKRAHRVYGDCTQIAVFTIKPDNSDRNNQELCEGISLKHALKTLPPAGVTGDGICLVKHVEYPWVDSPYPPRTHDALVLIQDCLDQFIPTPVYDAWSNPPIAEWDKPRETGVIELSFEDEDPVAKRNRERNELRDAENYTARLLQGKNLADLQVLVVPVDLKRIWESNWKLQRAFRFDYQMFTVLFHLSGAPGWKLNDMTPLGTECKFLIEIPKQELKDSTGDEVDFTGEARHNDYKRYISTQGFQIKYSTPQNPVMEAQPEPFPLSYGVEDQPNIWADFTFTPGVIPKTCEEDDHVVLTLGKNGTIPVPADCDDKDMCGGDILWVTFRKGAASPSRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7H2</accession>
    <name>A0A2T7A7H2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7H2"/>
    <dbReference type="OrthoDB" id="10559174at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="52447" checksum="BBADA380C8914125" modified="2018-07-18" version="1">MKTNTFLPHYLCTCNTTDPKSPEFVQITALAFGGGSTNSLAVGLDSGYFDLWYVDLSNSTTAPGSYSGESYSLFSSPYDFQESPTPFRLPGMFRPHEFFKTKAQRLPGSPDKVYAKSQRIGLLRQGFGRMRSLVGEVTTLSFSPRGEYVLVGTSLGGVWVYSVTWGTTERLYQAVGTSVSCASWEMEPGEEVDADGKAVIVVGMKSGLVVYLHFATSASCSEITAQPIEFYPAQLMTTLHRKQHPHGIKNLILVPLSKPVHRPGFPKETYPQYPTLLISFSGAPGIHIFRLKRNSVLRAVSPPSTPTKAKNSSMPKRLQPQQQQPPLIPTILGNIKSFGNTFLREPPSLDPYIPIYNKCINTDHVVFTTSATTPPELKGSAYGGVVENMALDPTGKRLIVTFSHGGDEESVVWFDTRALMTPAGGGVKAVGVLRHRKRDEERMVYGDVGFVGSFKGDACAGLVGRGGRGVSLFPAWLKEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7R1</accession>
    <name>A0A2T7A7R1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7R1"/>
    <dbReference type="STRING" id="42251.A0A2T7A7R1"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="571" mass="59551" checksum="32A0B38E3F6AD552" modified="2018-07-18" version="1">MNGTSMPTNGSTSAAMGNGGGGTMSMMSGQHTGNPLQHYQQQLQVSQATLGGQHPTYPQGTPVQNLSPHHHSSLSPTSASASSASSMALQQQQLLLNRQMETQSQLQLDKSRVTLILQINTELLRETISLQASGKGAGGEENKTPDKGYIECMRRLQCNLAYLAAIADRSHKPASQIPPSPTILLAPPGMPVLEKMYKDLQGLYPDVKPGNPPQSGQALSQGGGSRSGGGSQNASPKVNAADRPATQHQPQQSQQQQHQHHHQQAQQQVQQQVQMQPQQSPRHVTSPTPPAQVPHQVLQHQQPMQMQMQMQGMPGQQHVQFSPPHHPQPSPHNAPQMAQQHVQSVGPGGQMATNYALLQQQRHAMMQAQVQSSQGRQMQVQMGGVPSTMSMNSSVGGGMSNGIPVTSIAQQSGMPQQAMMGNMGMGMGMPPGMVPGMGVPMGMGAPMGGGPMGGQMGSPMGGQMGQMAQMGGQMGGQMGGQMGGQIGGQMGGQMGGQMGGQMGGQMGGQMGGQMGGQMGGQMGGQMGGQMGGQMGVNMAQMGQMGPGMGQQGFDMSQGMWNGGGWQSGQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A819</accession>
    <name>A0A2T7A819_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_706186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A819"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015675768" evidence="1">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="71" mass="7937" checksum="859CCA36307CE73E" modified="2018-07-18" version="1">MPRGCVFWPTGGVRAWALMFWGELLSGGISPSFPLEAVGEVAERKQKRAGRVKIALSNINKVRWPEQLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A862</accession>
    <name>A0A2T7A862_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_708265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A862"/>
    <dbReference type="STRING" id="42251.A0A2T7A862"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="243"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="34957" checksum="799A5F1D5219E790" modified="2018-07-18" version="1">MMTPSPHSNSQTRAPTSPSEEPNPTTLLLATAGEEDYNSAEDEDFDPAAFPQPTAEESESSHSEPEQLTTKPKQKRKRRRGSSSSEGSYGDISGGEGGLIKTRAQRLKESTEEGKVGGVLDGDAGAATTDVDELWRQMNSKPSPKRKSPLPETKQRRVPDEEEKSDKGDGGREGTNILGEETITISRTYTFAGDVITEAKTVPKSSQEAQTYLSTLPSASSVPTSSTSSTQANGLPPRRPPPKKRASAFDSAAAARKPATPAPAPKLNTLEKSRLDWAGFVDKEGIGDELKKHTSGDKSYLDRQAFLGRVDEKREKAWKEGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8E3</accession>
    <name>A0A2T7A8E3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_961817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU84008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8E3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8651" checksum="FFFAEC372A249BC7" modified="2018-07-18" version="1" fragment="single">PPYPLRTNTTTSPQSPAKKKKLGKPSTTPYCMYVIPRIQYKRATPLLHPSVFATNQPRTNQRPHTPPSCPPIPEKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A901</accession>
    <name>A0A2T7A901_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1118284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A901"/>
    <dbReference type="STRING" id="42251.A0A2T7A901"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU84182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="15585" checksum="93B0016E23713248" modified="2018-07-18" version="1">MHDFSDDSTHNWLEHQFFETSDVIRKPWIELCGDPRMEVLAGEQTPLHIAACLGLMPLVEEVLSDSTKETPAQNSAPPVAHSSKINKKNGSGNTPLHLAFQFNHMMIVEFLLRNGADPTIKNKAQLTPSELGVISRQEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9B6</accession>
    <name>A0A2T7A9B6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cysteine alpha-hairpin motif superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1117909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9B6"/>
    <dbReference type="STRING" id="42251.A0A2T7A9B6"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU84328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="70" mass="7442" checksum="0557A04EC6A5BC2C" modified="2018-07-18" version="1">MSNIPTVSRIAQTSPVSGSPTPPGPKPCCVCKDEKASRDECFLLTEDAETKCLDKVAAYKACMAGFGFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9X6</accession>
    <name>A0A2T6Z9X6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1011063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000586">
        <property type="protein sequence ID" value="PUU72300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9X6"/>
    <dbReference type="OrthoDB" id="5427826at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10337" checksum="5546A835ED3AAEC3" modified="2018-07-18" version="1">MEEVHNTHLLPRLPWPALSPNLNPIEEVWRYMKEEISSLQPAQGARRQWKMPFGLFGLNLQIPRFRPLSIQCLFASKQYLLQGGHTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA74</accession>
    <name>A0A2T6ZA74_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1137751</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000550">
        <property type="protein sequence ID" value="PUU72397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA74"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 15" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="17">
        <location>
            <begin position="929"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="901"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU72397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="965" mass="105600" checksum="247C172BE2A3BC2A" modified="2018-07-18" version="1">MRTKDTDTITMKETAAVESKSPEFGQLYHLLAPHDTIDVAPSAGRDAPLNPKSVEMFKTDDISVKFLSKKREVRARSPYLGTALFDIAHAPIVVSLIKSLADANKLVAAVCRGSAAVLDVKLSNGKPLVDGLSGAMPFMLETDLVKNGAKYEKVDQPWGAKMVTGIVVGEVQGCSNRMREHFRIQKSLTKGTRRITRVQTRTTTHPQIAYANSAGRSLLSTFENMYQEMQDFKAESEKVTGALQQEVVKLQDCKAESKKVTGVLQQEVVKLQEFKAKSEEQTIAHTQELVVLRPLRRTGVDIRRRFYATFRRPREPADGDPAIIIDGNRAAHSGDVITDVSLFRHGLLHDDDLETFQELYGLGWAEAESLLEYNAIVAIMDKRATHKANPRLRWPEDDELYFLHLVDYVQNATEDQLEAFLIDIVETYPPHWDLLTQWKPSGTMPFMLETDLVKNGGKYEKADQPWGSKSPRSLATTTTPFFHNLANPQSTTYDPATTSLPSPAPTPDIRKEWLTCLWKMSARTKLPLHSNPEPTTPHDLHYYLTEGWGGVEPQQFRDAKSFIRAIESEAGKLCSGKTSQQYAVFAPITQDQFATIDRIRRAHLKGHRFHYFNRGETLIVKLMAGLVQEMTSKGFGGRLDIKIAEMGLFEDIDQMGSSTFKGNGTYPSFLTNYPGAHTYTTQSFLLLQLSSTNYSEWFNSSTVSPLGALIGAANAHTRVYDVYINDDVSSTEIICNVANNVAPSSVTAAADDKVTFDRGDDIIDLSSKGPITVNIAPIASQGAGTVWPRSRNLSVTLSSALAAGDYLLRAEIIALHEADIDYTIACSGTVTPPHTFGFVGGYSHADPGILFSLYGGATSYSIPGPAAWDGKTGSSVLLPSTVVSSTVPTAISTSSVPAATSVSTPARTTSTVAPTATPSVTKPASGTSDTVPKYYQCGGKLYTGGTNCVAGTKCTFQNEYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAJ4</accession>
    <name>A0A2T6ZAJ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dUTP diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1009405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000516">
        <property type="protein sequence ID" value="PUU72517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAJ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAJ4"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="83" mass="9124" checksum="D34182119055B2B3" modified="2018-07-18" version="1" fragment="single">LVADGRIASRSGLVSKNFIDVGARYRGQVKILLFNYGDADFAVLENTRIAQFILERIVTTEVVDVDELDETAKGDSWFGSSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB39</accession>
    <name>A0A2T6ZB39_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_926385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000493">
        <property type="protein sequence ID" value="PUU72634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB39"/>
    <dbReference type="OrthoDB" id="5275938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16000" checksum="20164A65911B11FC" modified="2018-07-18" version="1" fragment="single">IDPNGDVLAILPTTTIKLQVSSKVLSTASLVFRSMFSPRFREGTALASGTALIEIEFPDEPPQALEVVFNVLHFRHDCVSAYLSYDTLYEIALVVDKYDLARALGPWKEVWLRRGAGDGGRGLFVMYVFGDKEGFREGCRKAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBF3</accession>
    <name>A0A2T6ZBF3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000464">
        <property type="protein sequence ID" value="PUU72799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBF3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBF3"/>
    <dbReference type="OrthoDB" id="5504564at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="22268" checksum="327ABB0C234E80F7" modified="2018-07-18" version="1">MISNCWKKSGLLPSPLNLGAVLPIVPSTLETDHGSSARSDSFLSTTTAAMQATLRTLYPDSNTAKFHKICKDFISDNDNLEGLAPDSSESGIPDASQLVEEQVQLGLLTRGVHDMEVSYLDAPGDSDENQEIDFVPSALLTYSEAIEHLYHLSRYLQSLPINTLPTPAGRKITLSTMVEQTTYLATAISLQVLQFYLPLYIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCH8</accession>
    <name>A0A2T6ZCH8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000408">
        <property type="protein sequence ID" value="PUU73169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCH8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCH8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="794" mass="86356" checksum="E6DB8D250F1C3558" modified="2018-07-18" version="1">MPITTTSSSTEAGSSPARAEADHRYGGRKASSKPLKPLKFSSLTSAVQKHHPPDFTGLTSEVQREGPVRPLQAHLDVLTQAEIALAIVDLLNLHYQHREVLGVIVTHIWNYYVLPNNLWDYYEGGKHKFMEAIAYDEFVGPTLESNSETQRRKRRANSSLEAVWGEGWEKKIEAESDHSSVLSEHYLREMAKLANRGITLIDAQEVLNYVMKARIARPGKGSVGSSPNPEYSAAWLISTLDATATTRMRETQSGIPEITSPLTPPIILPSTSGSSFSIEIIARSYAPTTISSASCDGITPPNGLPSPEPTPSSKRPRSGSNNNQLSQTTHHISSMIQSPMQSPVHSCRQSPALPDTGEPQPSPRSPSPRTGHVTPWVQSVSDSSPTPETYQVDSNEGDIDPNELQPLAAGQTVLEPSPSSRRSAPKRHALQVPIPALDSPLQSLPPSPPPVIITHPLAQSTSKKRLYSEYASEANTLLLRDATPTLDSPLQSLSNSALAHPATITQSLACTPEITALPLSHIFSLLDNWAYDSGIHTSVLERGFYNSPDVCQLADSACNVAIHTQLMISSALVQHPRVYLTALASMKSTNHHLISLPVPLIDCSDCYQIRDSSFPFEKYIASEKEVPGTRLLDTLNASTFGFGTISTQERVEAWWTTSGGDWQITASQIDPEGVSTVPFQAGELIAIPPQLLWSAKADNAQDDCSQGETSPGGKRPQTAIEMRGVWAIGDALLGLTSWDSLVVQVELRELFNAPAGSWFNAKFVNKIEASFDRKLTRMVNTLEKVNKQAFSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCP5</accession>
    <name>A0A2T6ZCP5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G protein-coupled glucose receptor regulating Gpa2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1104020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000397">
        <property type="protein sequence ID" value="PUU73239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCP5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCP5"/>
    <dbReference type="OrthoDB" id="5368598at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="255"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="555"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="593" mass="66279" checksum="B9C2D7140B89AA94" modified="2018-07-18" version="1">MDLGKRMKGSGGDYWVDDPVYGLSRLANRKIGDPTDLSLLTGQQLYILRIIALAAATISLSTGMVVGWWFVRMKRSFRHHLIMLLIFSDFFKASWQLIYPAVVFTRGAVASESKFCQAAGFFMSMGIEASDFAVLVIAVHSALYIFRPGLTAIGEGGLFRYRHSVYVAWLAFSILMPSLAYINSAPAYSAQGTFCYLPVRPVWYRMALAWVPRYIILVTILILYASIYIYVRMKFRTFRSHVGASTLEMDTIDLAIPGTQPPKDEGGLPQLDDHGLISTLPASDSRQASNASDQPFAKLSQAIAEKLSFPPPCSSEPRPWTYDGASSPPRRGSLPVSITNPEGGTGSSSEISHGKRARGGAADGASAELRRRRIAISRQLRLLFIYPLVYALMWIPSLVSNLLQYRDQFVRDPNYPLACMVAFTIPIQCAVDCWLFTIREKPWRYIPESNGKSFWSRYGFVRGEGCHGAGGKDGEGWRNRKSMTFEARKAYERREEERKEAAELWLQRLQRQDEKGRLSSGSAPLVPLVPTEPKKAFRSWWDGFSDDLDEIVEEAKNRRDSQGHLSHADELSSLEAGMGGGSRQDNHLTSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCW5</accession>
    <name>A0A2T6ZCW5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_547389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000386">
        <property type="protein sequence ID" value="PUU73341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCW5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCW5"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000219">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000602">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="375"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="507"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="738"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="830" mass="93057" checksum="5DD8ED5DE84EE422" modified="2018-07-18" version="1">MHFSSLLGTVYCRGNLVFTPDGNSLLSPVGNRVTCFDLVNNKSFTFSFEHRKNIARIALSPQGTLLLSIDGDGRAILTNFSRRTVLHHFNFRSVVHNVKFSPDGSHFAVAAGRKIEVWRTPSYLEEREFAPFIKHREYTGHYDAINHIAWSGDSRFFLTASKDLTAKVYSLNPVEGFVPTSLAGHRDSVIGAYFSKDQESIYTVSKDGALFEWKWRARYKEDDIDDEEMKDEDEPKDERWRISQKHYFLQNHAKAKCVTFHQDSNLLVVGFSSGIFGLYEMPEFNMIHTLSISQHGIDFVTINKTGEWLAFGASKLGQLLVWEWQSESYILKQQGHFDAMNSLTYSPDGQRVITTADDGKIKVWDATSSFCIITFTEHTSGVTACEFAKRGNVLFTASLDGSVRAWDLVRYRNFRTFTATSRLQFSTLAVDPSGEIVCAGSLDSFDIHVWNVQTGQLLEELSGHEGPVVSLSFAPDGRCLASGSWDNTVRIWSLFTRTQTSEPLQLQSEVLRVSFRPDSRQVAVSTLDGQVTFWDVENAEQSSGIDGRKDISGGRRAIGRTTAANAAGSKHFTAINYSADGTCILAAGNSKYICLYDIASGTLVRKFTVSVNLSIDGTQEYLNSKLLTEAGPIDLLDDAGEASDLEDRIDRSLPGASRGDMSARKARPEIRVTGLSFSPTGRSFAAASTEGLLIYSLDHVVIFDPFDLDVDVTPATTLSTLRDEKDYLKALVMAFRLNERYLIHQVYETIPHQDIELVVKDLPLVYLSKLIRFVTEMSEEGPHLEFALLWLEAVVSRHGKYIREKRGEFETEMRGVTKCVQRIQNELARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD94</accession>
    <name>A0A2T6ZD94_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_922835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD94"/>
    <dbReference type="OrthoDB" id="3944494at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015681601" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8829" checksum="AE719ED6D2A96652" modified="2018-07-18" version="1" fragment="single">VQFLEYLLLLMHMTGGGPPRGTEMSTLQFANSYFRHRNVFFLRGELLFVTSYHKGQSRYSTQKYIPRFLPGAVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDW0</accession>
    <name>A0A2T6ZDW0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1094584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDW0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDW0"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="18"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="163" mass="19324" checksum="AEF8DB4FE21749A3" modified="2018-07-18" version="1">MSVPKNFKAEEAQNLQDIEKQFAVKAVIHAQTYWSILERRAGTDLRLTRIDQEIYDHLLETFPDFDPKELLNEDEMKSKSGKEKWRSFLMRYEKRVEDYNFGTLLRTDAKVEYEKDTTIFVPRMQFYAIEIARNRSGLNDWIKAAYDKEEEAKRPEAAEKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDY2</accession>
    <name>A0A2T6ZDY2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1094498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000351">
        <property type="protein sequence ID" value="PUU73707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDY2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6651" checksum="E80CD092C7763D5C" modified="2018-07-18" version="1">MGGSLGNRSLRLFYRGRSCLRLEECYNFPMPVDRGNQERYPTIIVRLVEMGIILCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZED0</accession>
    <name>A0A2T6ZED0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1161197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000337">
        <property type="protein sequence ID" value="PUU73858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZED0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015580882" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11027" checksum="91CEB6F852786EB9" modified="2018-07-18" version="1">MIFDMHTIVSARVIPPLLFLSVLVPSAETFSAPSPSYPPRLLERMLKSSFSTPLLSLERLTPSWETPTLRPSPPKSSFKTSPLSLKSCLQKVNLSCRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEP1</accession>
    <name>A0A2T6ZEP1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_494825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000331">
        <property type="protein sequence ID" value="PUU73968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEP1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEP1"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015457380" evidence="1">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="9636" checksum="EFC3F7232691CFA2" modified="2018-07-18" version="1">MTLRPVSFLAFMSLDIITTQGKEFDIPHAKGIIAGPAGALWPACLIHPIPARLLSTHPTFTLDTRTPVTSIAPLDSTLHPMSCILCEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEP4</accession>
    <name>A0A2T6ZEP4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1134257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000337">
        <property type="protein sequence ID" value="PUU73864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEP4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEP4"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="13465" checksum="2D494B78AF94C91A" modified="2018-07-18" version="1">MTRTQRNSVKADFEKSQEISIILISIMAGGLGFNLTAVCKAYIIEPLPNPAAESQEIDHIHCIGQTWPATSTRYVMRGSFEMKIVELQKKTELAYLSMSTGMFSGKDAMDNNLENLSALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF14</accession>
    <name>A0A2T6ZF14_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">VHS domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1133965</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000325">
        <property type="protein sequence ID" value="PUU74062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF14"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="189"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="500"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU74062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="622" mass="67756" checksum="027F888A5A145095" modified="2018-07-18" version="1">MAARDRFGAFPQEPNGSKLQRFIQSACDPVNFEPNLALNLEIADEINKRKGNAPREAAVAIVNYINHRNPNVSLLALNLLDICVKNCGYPFHLQISTKDFLNELVRRFPERPPARPSRVHLKILEAIEEWRGTICQTSRYKDDLGFIRDMHRLLSYKGYMFPEVRSEDAAVLNPSDTLKSAEEMEEEERAAQSAKLQELIRRGTPADLQEANHLMKIMAGYDQTSRTDYRAKAAEEIGKLREKARLLEEMLGKVHKGETIGQQDTFEELASALKTAQPKIQKIIEEESEDPDAVVKLLELNDVINTTVERYSFVKRGDLDAAKALPLMAGASPSAAPPPPATELSLIDLEDSANGPSAPASGKPASLEDDLLGLSFQDSGSSSFGQGGGIALGFGANTGIPGPPLLSSTVEANTAGQQRITPSTSPVPQVTRQPPVVPNYFQNLATPSTQPMTAGGFVSPSIQQTPLPPVQQNNGGNANNEDDDWAFTSSLPPEQPAPPPVSQNELMILNSNLHILLDIHRPATMPDGPILVKAKFSNNASQPIQDLTFQMAVTKTLALKMEPQSSRHLGARQRAGVTQLIRVSGVPRGSGSNVKMRWKVSYRVGTGPLNEEQGVIESLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF20</accession>
    <name>A0A2T6ZF20_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1196481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000323">
        <property type="protein sequence ID" value="PUU74097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF20"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="301" mass="33812" checksum="23F30EFE01DDFAAD" modified="2018-07-18" version="1">MVQKPSAISIEPVMDIRDLTPDRILKLQAKYEGVRIFQNVSPKDLSDWKDRYPEAIENPKIRIEYNFLSKSLAIKCNLLATQAALQIFFNSTVLLSLREKIEVSEMRKRVTVGSGTTFIGFKGNWTWVSEKLPDAYIQLQNALPALGAEAGDDQASQDEKTVIDSIDEAIKLNDLAEKLIELNQAGQLSSPLVGKLGATIYGYRASEDGLDIVSSFQETLLPQKEADRGILTDFLLTMRDLLSESLPEGQDPGERITLSLAILVEFIERLIPHTEHFRAYRRAETLLRKAGVWGEEEEIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF63</accession>
    <name>A0A2T6ZF63_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="9">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1093587</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF63"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF63"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="99" mass="11731" checksum="8CF5DCA9C9421A93" modified="2018-07-18" version="1">MASRGGGGGRRVLLPPINFIFKLLQSHATVQIWLYEQLAIRIEGKIRGFDEFMNLVIDDAVEVKLKTKEEEESRRELGQFFFLFLSFPFFSFLFRHSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFB7</accession>
    <name>A0A2T6ZFB7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1001545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000319">
        <property type="protein sequence ID" value="PUU74173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFB7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFB7"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="48"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="440" mass="50108" checksum="CF56C3DD14789B2F" modified="2018-07-18" version="1">MPTTNTEHVSTIPPKDSLGTEIIIALMGVTGKIQSLLEPCIRWLRRATGSGKSYFVREVSGNSEVEVSGDLYSCTSKVKSYSFEYGGARITLVDTPGFNDTNRSDMEVLKEITDWTSESYRKERLLSGIIYLHPITHTRLEGSALKNLRMFRNLCGQKVLGNVFLTTTQWSNVNLREAELRENRLRSQDFWGGLIGKGATLQRFHGTRESGLELIHKLMSNIPKPLDIQDQIVKQNMTLLETSAGKCINEELIAQEKRHKEEVESLEKERQEAINAKDDEMNKILAEEQAKVQKKLEKAAAEKKLLAELHAAEVRKREEEERKRQEEMARREKSVIAVATEDISVIAHIHTFLGGYLTRGRWIFDINNHEEFESNTFAVEIQYHVKILSGVEIPVKTLRELSGEGMGKSNYIFVGEVRYVCKSRTPIKRGGRHFVIFRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFD7</accession>
    <name>A0A2T6ZFD7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1133754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000317">
        <property type="protein sequence ID" value="PUU74189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFD7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFD7"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="15420" checksum="667CE1CFDE7A32BE" modified="2018-07-18" version="1">MSTQMFNKPFKKWKDTQVARGGVSAGDATLVIEFGTFTSPIHPSSLVGSRRGLPTNSRFGMGVDGGEMETINVKQKHENDIVRAVISSTKAKPVPMSEEDAEIVAQYEIHKAWMEEQQKINKGKRVERRAEWTSVGGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFH6</accession>
    <name>A0A2T6ZFH6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_468416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000311">
        <property type="protein sequence ID" value="PUU74251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFH6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFH6"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="8"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="9257" checksum="BC02D98BADC69537" modified="2018-07-18" version="1">MKRSGIQRDVLALYRLCLREAGKKPKEVQDNFRNYARENFQAHLDIDRRDFATIEHLLRAGRRKLEVYSQPGVKNISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFK7</accession>
    <name>A0A2T6ZFK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1103551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000311">
        <property type="protein sequence ID" value="PUU74252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFK7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFK7"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="170" mass="18600" checksum="CD266AC3B9FBD475" modified="2018-07-18" version="1">MDPLTLPQGYWQLRSLGLGATCPLPVSAEDIYGDPILSIRISAVSGVAKALTSQVLNVNKLLASFAINGTKAIRHLGLNDEPGLDYECELVFMIGNEARDVSERGALNHRDCQLKMYINTPAQVNGRTVQNSPTADMIFSLKDGDIVEVEIEGIRSITNKMTFERTKAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFP0</accession>
    <name>A0A2T6ZFP0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFP0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFP0"/>
    <dbReference type="OrthoDB" id="5420387at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="958" mass="105510" checksum="2C13D5DD6192CEBB" modified="2018-07-18" version="1">MRFSIKQIMPIKTLVMLRGKEEEQEMMNGWSDEDHAQSEGAYNHRRHRISKSGFVSAIRKTLGKYSASRTHSPVPTRSNQTSVPLGPAHDNDGRPAPTPLNNKLNQKDSPSIPTTKDRPDQTSSAKEENNPTWAAPDYNPNPEPTALSPREVQSLFSGAPVFAASGNKASGVLRPRVMFPFDENAEGLRGLSDCPPIEHAAFSLCTSRPHRTLNGYENTSDHGLINEEPSMLSFQGIEPGTCGWEYFLKYPVGDSENRDEDDDDDVIDGGGRERGTRRASLGNAKGGLRTVEMEYIVERLKELGEIYHESKIKPPNGRRPLPREAQWGILGKYSPLELYTHLFTRLLYPPTRITTADFHDPYSLKVQIVALRETLAMEKLWLNFSVVGWRIRLGQILWGENSTVEPANGECGEEEEAAPLGSDAEKVWLLLQILLACELVVRMDAIVGEANSEDSSVDSVVSTDELLDEFKTIGSKKVEWDVTLARRWLENVKIVESEVVGKEEKTKNLSVPAKKGWFSSSSSEPSPMDQSEPEGDDDDESASSRSYEALICPQNHSRQLSGLLYFARRLQWPQIETLSATLQEKFSSSSNFSTPSHSVAVTPLDTPLSVAGGNGYFPPFARTKRVRELPSSGISLNSGYEKDGKRPTPPKAVRSGGWLSRTYFSGLILPGEGLPHFLISTLLENDASAIEKLGFQANLYSGFQCDEMTWWSSFSTVGKVLAGYEGSREVGGWIGPCLGSGLGEIGMVDDGWVDVITAQLDEEPRAKRPNAIKEGSNPLGKGPKNKKVLSTDFTMPRDEIDEEEKVILEGLVFKGVAREPGELSGELLRYEVELHFSILPLSEKLQIKLTHDVFFVSSFPCLEPPASMNSVKSGHLLHKDFSYQPVTVDALTEENFKDKNSILVVEAGSVGGGGEVLARAWCSMIGTHAIIGRKGRTCLGCCVREARGLGIGVVIRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG46</accession>
    <name>A0A2T6ZG46_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1000416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG46"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="6">
        <location>
            <begin position="75"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="278" mass="31523" checksum="15495AAFB30970AD" modified="2018-07-18" version="1">MSESNVVQITAPVTVVGDIHGQFFDMLEIFKIAGYCPDTNYLFLGDYVDRGLFSVETISLLVCLKLRWPSRVYLIRGNHESRGVTQSYGFYTECSRKYGSANVWRHFTDMFDFLTLSVVINNDIFCVHGGLSPSIHSIDQIKVIDRFREIPHEGPMADLVWSDPDPDRDEFSLSPRGAGYTFGAQVVKKFLEVNNQSHILRAHQLCQEGYQLLFDGLLSTVWSAPNYCYRCGNLASVLEVGYHGLRYYNVFEAAPENSEHRDAAAQQQDTGAVVEYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG55</accession>
    <name>A0A2T6ZG55_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1092961</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000302">
        <property type="protein sequence ID" value="PUU74404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG55"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG55"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000018">
        <property type="entry name" value="Putative MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015493477" evidence="6">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="484" mass="52403" checksum="1FF7357C35F19F4D" modified="2018-07-18" version="1">MCIITLAAALDATSLSVALPTISKALHGTAIEAFWSGTSFLITSTVFQPNFASLSDIFGRRSLILVALVFFTVGAIVAAIANNFTIILVGRSIQGVGGGGIISLAEITVTDIVPLRERGKYFSFLSTMWAIGSVGGPLIGGVFVQEVSWRWIFWVNLPFCALGFVLIPLFLNLNHRTTSFLEKLGRVDWIGSVLFVGSTMSLLIPITWGDVMYPWDYWRTLAPLLLGVVGLTGFVLYERFLAKEPLIRLGVFSTRTASVNYLGTVMHGLILWSLLYYRPLYFEAIKGFGPIMTGVAAFPVAFTVMPACVVVGYLVSITGRFRWVLWLGWALTILGMGVLILLDLDTPTVSWIFITMVSGLGAGILIPGMAAGIQAAATDEDMAYAVCMFSFFRTFGQAFGVAIGGVIFQNALKAEVAKHAVLRGMAGQYTEDAVALVQIIRMMPRGMEGREELRISYVAALRAVWKAMIGFGAVGLVTSFATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGH9</accession>
    <name>A0A2T6ZGH9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4360 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000288">
        <property type="protein sequence ID" value="PUU74603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGH9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGH9"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754488" description="DUF4360 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23412" checksum="65177501473C8916" modified="2018-07-18" version="1">MKYSVSAIVLGFFAAFGAATPTPDDKPDDDQVIVTGVTYAGSGCKAGTAHISNSPDWSTFTIIFDDFNPTIGPGSKISDQVKNCNLNFQANYPPGYQYAIYKTDYTGYALLDAGVTVKQTSSYWFAGFVSDRPTFQSTWYGPYNNQYHFTDTLQSALYSPCGNSTSLNINTQIFMTSSNPKAHGSINPPSELDTLLATSKIQHAYYVNWRRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGW7</accession>
    <name>A0A2T6ZGW7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000277">
        <property type="protein sequence ID" value="PUU74719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGW7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGW7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="26340" checksum="59FDB73C72A1A232" modified="2018-07-18" version="1">MVGKGAKSGRRGGPGNLRARVVKVEKAKGGKRLLDDRKYRVVGGGELVLGGKEGDWKVYKGFKKVISSWENNEMRLEDKIVLDGSEWGLSGKGDWEVWMDSMEGVEGEDEEDSAKVVEEAISELREKEKKEIGEREKEKMEVKKEEELSESEEEVEKKRKVDKGKRREVVVIESSGVEELGTIEKWKIEKKMKEKREKEENRKREKEGVINRGKDRGMGRDSTLELWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHG0</accession>
    <name>A0A2T6ZHG0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1110374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000260">
        <property type="protein sequence ID" value="PUU74930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHG0"/>
    <dbReference type="OrthoDB" id="10535102at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="292" mass="29889" checksum="45CE4148999220E2" modified="2018-07-18" version="1">MPPSSFIPTESVPSQFNKRNQTETKGGHSSNGIPLPAILGVVFAGLSLLVAVITYRRLRGRIPLADSLPPRLREFARRCPLFAPEPKEGPEGPDAPPQQGIPPANPPPGSPDAPQQQGILPASPDAPPQQGIPPASPDAPPQQGNLPANPPSVSPAPPPQQGILPANPPSGSPAAPPQQGILPANPPSGSPAAPPQQGILPTNPPSDTPHANPQRDPSSANSRSDTPPAAPHLGPPTISQPGTATTTPPTGPPVSSDFNTSNKNPHINFTFGNNNSHAGNIFGAFNNTIRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHH4</accession>
    <name>A0A2T6ZHH4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_905670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000259">
        <property type="protein sequence ID" value="PUU74941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHH4"/>
    <dbReference type="OrthoDB" id="3944494at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015769348" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8781" checksum="00AB5ED6D5B20BE3" modified="2018-07-18" version="1" fragment="single">VQFLEYLLLLMHMTGGGPPRGTEISTLQFANSYFRHRNVFFLRGELLFVTSYHKGQSRYGTQKYIPRFLPGAVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHZ7</accession>
    <name>A0A2T6ZHZ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHZ7"/>
    <dbReference type="OrthoDB" id="5485987at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="405" mass="45281" checksum="320665155074C31C" modified="2018-07-18" version="1">MAFMKRVEIRVRKPAPIEAPKEGRIESNGGPHPPVHPQKKRPTGSVARKTAKRREPIIISSPEAPPPKKSIREKAKSSVGASKPKKRKAEVLESSEEERRPAKSLAVPLKFHKKKSTPSSLEDDKIHSPEVGLKKSRPSLTSRAVPASPHSIQHDGVKKIVRPRPILDPLPSAKGKANPSIRSDKKAKEKPSSSSANSTKPKKVKRANADPEDTRSLKTSTVRKGFEKNVLEDEDSDVPISIRRRREHSPLSIHINGEVFLPPKLGEGTAQRPTKEAMRKEALDKFALRLKLAKSDFLALCRSRDEYPTRKDLDMRAFPKDFQFEPFNQTPRIPPSPEVDRKSVTQAEAAYAYLTGNWSPGGADIENIPKSSSKKKKKNHTAKTHETIRKEEPKARKKPRESDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI43</accession>
    <name>A0A2T6ZI43_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl phosphate synthase preATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1091020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000247">
        <property type="protein sequence ID" value="PUU75167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI43"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI43"/>
    <dbReference type="OrthoDB" id="10068979at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015421580" description="Carbamoyl phosphate synthase preATP-grasp domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Carbamoyl phosphate synthase preATP-grasp" evidence="2">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="130" mass="14077" checksum="0390C2169522D98C" modified="2018-07-18" version="1">MALPRSLALWALLPSLIASSRKAARSLSLLPKLLPTPPATGNSPPKTTADSQRWLSIQQAVCSLLRESYLSYRRHHRRKRTWLRGAIAGGRDLVDVTKVQVIGSGGLSIGQAGEFDYSGKGAIFCFGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI48</accession>
    <name>A0A2T6ZI48_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_367429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000247">
        <property type="protein sequence ID" value="PUU75152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI48"/>
    <dbReference type="OrthoDB" id="2389680at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="357" mass="38660" checksum="EC06AB5D2CC02E3F" modified="2018-07-18" version="1">MPRRPAPSPSGGDPPQSTADSTGKKRKRGKASTTSPPSSTTADIPKRDKKRSKKGTTSPSPSNPPPPTTDIPKRDSKRSKRSTISPPPSTTADIPKGSSKRSKKGTTSPPPASPPPPPPPAPSFSSLGFHINPRELPKATITNPAKTPDANKPEVAAATTTTTTTSTSLSAMTATVPATPTLAPLEGLAKVLQEVNKVWYQRYQKESERLQDVCRACCAQKDNELKEANEKIKDLQKDRIAVLEGTLNVRGAVDYARDINKLAEKGGLQEGINSLYKTDHEFVRILHEQGVKRGLSRSDVKRCVGGLYHALSKNVHGNNGNILIRKSDFSDNDRAVIVSLMILQQGWPDHHLKWSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI96</accession>
    <name>A0A2T6ZI96_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1103076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI96"/>
    <dbReference type="OrthoDB" id="2439692at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF2">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015748536" description="DUF7707 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="26"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="20848" checksum="073196AFF9C9B0A2" modified="2018-07-18" version="1">MQSFVFTAFVAACSVLSVSAQTYPPFNVTAVPEAIRTQWCRAQTAACPLLCGDQDKSAAQNQCFPDNLYFTCVCNDGTTPNLTEYSQTIPYFRCQAEVKGCQDACTGNSKCQSDCAANKPCGATDPTRLNTSTITSTKSASKTSSPTGVFTTTDSNGFAITGTATGSPAGTKSAGSFMLEAGSAYGLGLVAAGIAIGAALMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIA5</accession>
    <name>A0A2T6ZIA5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000242">
        <property type="protein sequence ID" value="PUU75225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIA5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="20461" checksum="87F286B621E46020" modified="2018-07-18" version="1">MTGTLSQEIPTASSLMDISQDITFDGYIQYHQQIILDHPAELESSESSRMISPYPPVVNELHSEYSESPTEIDSIPSESAPMPESIHTSPQIREAIYALCVYANWTYPKLHEVFGVSLELLYCIHRSTHQKGTLSSRGDRGRLQIANSGITQHLIETATASSYQRRLPYTRIAELVCSRALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIN2</accession>
    <name>A0A2T6ZIN2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Vesicular-fusion protein SEC18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1195535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIN2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIN2"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000026">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000012">
        <property type="entry name" value="Vesicle-fusing ATPase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000187">
        <property type="entry name" value="Vesicular-fusion ATPase SEC18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="14">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="272"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="553"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU75341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="773" mass="85218" checksum="7B9F01C04E7F2694" modified="2018-07-18" version="1">MSGYGRGYPRGAAVAPPRAAVAPPRAFRLTKSPSEEFIVTNFVAVSPRDFPAEQYVICDGRYILTVRPFDTIEPGYAGFSSAHRDWAQWSLTDRITIAPFDPFAHGRAPYLGSLDLEVGFAARKISDESYDQDDLTKLFIRSFQNQIFAPGQRTIMDIRNIKVLIVVKTVQIAKSPDKNSALPSDAPTTANPSDYGILTPHTYITFYKDAKSPIKIKGSNKRPAANAIIQPNFKFEDMGIGGLDTEFSQIFRRAFASRIFPPGLVEKLGIQHVKGILLFGPPGTGKTLIARQIGKMLNAREPKIVNGPEILNKYVGQSEENIRKLFADAEKEYKEKAEESGLHIIIFDELDAICKQRGSKNDGTGVGDSVVNQLLSKLDGVDQLNNVLIIGMTNRMDMIDEALLRPGRLEVHMEISLPDEFGRRQILKIHTNKMRENNVIDPDVDIQELAAKTKNFSGAEIGGLVKSASSFAFNRHVKVGTVAGISEDIENMKVNRQDFLNALEEVRPAFGVSEEELEQAVQGGIICYSQNINSILAEGRLFVEQVRKSERTPLVSVLMHGPPGSGKTALAASIAKASEFPFIKLVSPEAMVGFNEMSKVSYLSKVFMDAYKSPLNVVIVDNVERILEFVPIGPRFSNPVLQTLLVLLRKQPPQGRRLLIIATTTERSVLAQMDLLNAFDAEIAVPNVANHNELGHVLRELQAFNSDGERQQVLHDLYSTTRTKQLNVGIKKILMGVETARQDEDMAGRFVSVISKGVGENGVGLQGGEPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK76</accession>
    <name>A0A2T6ZK76_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1130589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK76"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK76"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35523" checksum="57EEAD6E83ED8939" modified="2018-07-18" version="1">MFPPRRGNDSLDAGEIYLISVFGTNEVLAAVGTQAYLQKYQEGHWAQMWICETNLDGRISMRNRDTKMFLGSCEYEELNCAVPHPRVWEWLTFTWLSVGGYSLKVHCGDKDKLRPIQRVGGRLKGGKECIQLGLHKIKDSVFRRFEWVIPGRLARSSAPYYDGEDADESINDGSIEFLNNYKIKNIISLNSVELSPRQQGRLRAAGISYSHIKAVECTAVTQEQFDQIWKAYDKAGATIVYCGYGDGRTGMAISAIQLFQGRALDDQDYRENGVQSLSQLAALNALSDRINSVEKHSGPVGTPDTRLPPYEAFVHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKC1</accession>
    <name>A0A2T6ZKC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L10e/L16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1067057</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKC1"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.300:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="219" mass="25152" checksum="EF0686F9E94EDBDE" modified="2018-07-18" version="1">MARRPARCYRYCKNKPYPKSRFNRGVPDPKIRIFDLGRKRAGVDEFPLCVHLVSNEYEQLSSEALEAARICANKYLVKIAGKDGFHMRVRAHPFHVIRINKMLSCAGADRLQTGMRGAWGKPNGTVARVNIGQIILSVRTRDTHRATAIEALRRSQYKFPGRQKIIVSKNWGFTPLRRDEYLEKRQAGEVKVDGAYVQFLRPHGQLEDNIRRFPEAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKV7</accession>
    <name>A0A2T6ZKV7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="15" type="ORF">B9Z19DRAFT_1089001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKV7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKV7"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="11">
        <location>
            <begin position="282"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="538"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="14">
        <location>
            <begin position="774"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="936"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1018"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="639"/>
            <end position="641"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="646"/>
            <end position="652"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU76112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1070" mass="119700" checksum="69870DEFF13EE32F" modified="2018-07-18" version="1">MVKKAIDKRIPDLIRNGVQEKKRSFFVVVGDRGKDVILNLHYILGSADPKQNKSVLWAYKKDLLGFSSHRKKREAKIKKEVKRGIREANTEDPFELFISLTNIRYCYYKETEKILGNTYGMCILQDFEALTPNLLARTIETVEGGGLVILLLKTMTSLKQLYTMTMDVHSRYRTEAHGDVVARFNERFILSLADCASCLVVDDELNVLPISGARGVTALPPVSSEEGMTEQRRELLELKASLVEVQPVGSLVNISKTVDQAKAIMTFIDAIAEKTLRSTVTLTAGRGRGKSAALGVAIAAAVAHGYSNIFITSPSPENLKTLFEFIFKGFDALNYSDHLDYDIIQSTNPAFNKAIVRVNIHRQHRQTIQYIQPQDAHVLGQAELVVVDEAAAIPLPLVKKLMGPYLVFMASTINGYEGTGRSLSLKLIQQLRDQSSGLTKAAQDGETADRSGKTSKRSDAAGYGGRSLREATLSEPIRYAPNDPVEKWLNNLLCLDATLPSNRSTVHGTPDTAKCELFYVNRDTLFSYHPVSERFLQRMMGLYVASHYKNSPNDLQLMSDAPAHQLFVLLPPVQEGSKNIPDPLCVVQISLEGQISRESVQQSLARGKREGGDMIPWLVSQQFQDEDFASLSGARVVRIATNPDYTGMGYGSRALQLLTDFYEGKFQSLDEGATYIDEEMVRVTDEEIESSTLQTDNIKIRDRESLPPLLLRMSERRPDTLDYIGVSYGLTDKLHRFWKKQKFAPVYLRQTATELTGEHSCVMIKVLASKDNDWLGTFAKDFHKRFLTLLSYEFRKFPAVLALTIFESANAGARLSGQQDTPLTKTQLDEYLSPFDLKRLESYADNMLDYHVIVDMIPLIAQLHFTGRLRGFVKLAGVQQAVLMAIGLQRKTLEDIEKELNLPPAQVLAMFQKTIRKVATCFRHLLSQAISETLPQEAGKSKQKKINDGNNDNEVETDEFHPIEKSLADDLQEGGEEVMASMKLKEKQRELINSLDLSKYEIPSTGSADWESAEKQIKSATGEHSSGKSTVVSIKTKSHKKRKAGETAVEIYEQEMGKAHKKGKKSKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLG9</accession>
    <name>A0A2T6ZLG9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SRCR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1149829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLG9"/>
    <dbReference type="OrthoDB" id="5409312at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015407195" description="SRCR domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="24174" checksum="AD475C5A61CD4DD8" modified="2018-07-18" version="1">MKLILITAGLFASSIITTSASPHNRRRGLSEWLIGHFGGIVGEIPKNLNENDGTEISNDSDALNTAMATPTMNNLAVLASSPDETAGPTTTPTPTAPAAGAVDQAPTTITAVPTATPAVVKREVHYLDDSRHERAEARLEEEEVNMLVALLNHSFGHEDLRVGGGCSPMQRKGCAGNSVVECGSEGAWELVADCDIPGLDLACRAVRGQDFWEGGWAVSVICLESDLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLM2</accession>
    <name>A0A2T6ZLM2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_990754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLM2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLM2"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="910"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1005"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="912"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1067" mass="118044" checksum="DCED8CF6A1F2AD1B" modified="2018-07-18" version="1">MPAPENAPPQDPSPEGSDRGGSSLRATGVLGVEWDDSDRLFDSTGGLLSSSPEDDDHADKDFLGGGDEERRSAFYNYKQEKTLKQTDAKMFYQQQQQANSGWNSPVMRASTGNWAGPSSGGGIGNLSRAGSVRSFTSSHQPPYLYHSHHQYLGPAAGGSTLSITASRSLGNATPAPVGMASLEKPKEHGGVQAPEMSRFDPHGVIAPAARQRGDFINSQGEMLPEPQGGYVGGDLALSAELSTIYTNVQKILDIRHKYLRVSLQGHADNPKDDPGWKIYPLPPPPVWVEDGTPHPPTPKGSGGSAQEIEGAKKEANATAQKEARKPGQDIGENFAFEECEIPGEDEMEFKKDDHGVFQVYENKKALDAGMPVVAIPTLREYYIDLDKVLDISSDGPSKSFAFRRLQYLEGKWNLYTLLNEHQEMADSKRVPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKMRRCPDEKVLFRDGKHLTLTEVFASINLTAYDLSIDTLDMHAHTDSFHRFDKFNLKYNPVGESRLRTIFLKTDNDIKGRYLAEITKEVFQDLEASKYQMAEYRISIYGRAEDEWDKLAAWVVDNKLFSHNARWLIQVPRLYNVYKSTGLINSFDEVVRNIFKPLFEVTKDPSSHPKLHVFLQRVVGFDSVDDESKAERRTFKKFPSPPEWTVKSNPPYSYWIYYLFANMASLNVWRKQRGFNTFVVRPHCGEAGDTDHLAAAVLCCHSISHGILLRKVPLLQYIFYLDQIGIAMSPLSNNALFLAYDKNPFLSYFKRGLNVSLSTDDPLQFAFTKEPLIEEYSVAAQIYKLSAVDMCELARNSVLQSGFEGAVKARWLGNDYHVPGPEGNNMDKSNVPNIRMAFRHQTLREELKMLERYTSAQVVASSGAPGPQGAILAGRLMLPGTPFQVSRPHSPTTSMQTNPTSVQEPPSLQGGPPSPTQCPISPGFPKLSASVHTYDFQGQSASPNPPLPPGTESRDGYPGFPVLARANTIGTATVLRHHTGGSSGSPGGYGDYHISGSEPRVWPGVISRRQTSISEKDGTSKGAENEAKSGGHGSVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM42</accession>
    <name>A0A2T6ZM42_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1129620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000184">
        <property type="protein sequence ID" value="PUU76559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM42"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015723591" evidence="2">
        <location>
            <begin position="23"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="212" mass="20108" checksum="FEC1BCA984BEBB90" modified="2018-07-18" version="1">MRSSSILAKLVTLASIVGIVAGDDVSLGKPSTTSTISTISANPTCTAIGGCKSVALPTTTTDIPKTTCNSCKTTSVPTVTPPTATPPTVTPPTVAPPTIYPTPKGNNNTVTTPIYPSKNTTLTTLPSPTGNGTIKASSKPTTSGSGSGSGGGSGGSGSGGSGGSGGSGGSTGTVAPAATTTSRPAGSTGAADRNGASMIAVVALGSLVWLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN36</accession>
    <name>A0A2T6ZN36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1129015</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN36"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015437760" evidence="11">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="255" mass="27569" checksum="457BAA7F6A6A60E9" modified="2018-07-18" version="1">MRVPAFLSALLLPLTASAQLFGSNSVNPDPSAQPKLNITLRASFPDISNELVNVGSGNPSVKLVNGIPTRVSFDLANFEASPIFVEAVGGSLWDAGKDVAVRNLTSKKLGGVEVPKDQKIEIPYEFVNEMHPRDILLNLVMVLRFEGEIVTVTAYNQTVAVVEAPTSLLDPQLLFLYLILAVTVAYSGYFVYNTWLASVIPITKRSKSDAPKLVKPAPLLAQSGKYDESWIPAHHIKKPTTSRAKSGAKGRKGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNZ4</accession>
    <name>A0A2T6ZNZ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1102004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000161">
        <property type="protein sequence ID" value="PUU77144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNZ4"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="367"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="460"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="464"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="588" mass="65709" checksum="F3F1032364901121" modified="2018-07-18" version="1">MDAKPQRPSRAIRRQDENANRPIIHNKSASNVSSAAANAALGNMESQQPTGLGLRAAARRTAFGDVSNTTKGNNVTTSGKEGSKGGVIVIQDKQGQKTTGAISKPAQRAQGLKPASSIISQTSVSSQHVAPSRNVVRKTTVYQDNKHPSPKRTSPKRTSPKVSRDAVVKKESQQFGRQTTRPRSKSRASRPLSGLLRIKQHQAKGESPVYSDQASHSYSDRYLDEDQESTAAEAEDDDDEEASEDEASGGVKTAEGQLEVISDYESDEGDDDETEYNSARARPGDNTTGVTTQILVPKITSQTRRELSKVQQEFFDDEDEGDISMVAEYGDDIFEYMRELEAKMLPNAHYMDHQSEIQWSMRAILMDWLVQVHTRFNLLPETLFLTSNYVDRFLSAKVVSLGKLQLVGATALFVAAKYEEINCPSVQEIVYMVDNGYTTEEILKAERFMLSMLHYELGWPGPMSFLRRISKADDYDLETRTLAKYFLEITVMDERFVGSPPSFLAAGAHCLARHMLKKGEWTPAHTFYSGYTASQLEPLIHTLVECCENPKTHHGAVYDKFADRRYKRASLYVENWMKTEVAEESDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP54</accession>
    <name>A0A2T6ZP54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_987421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP54"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="224" mass="25114" checksum="8426D51F2DA88897" modified="2018-07-18" version="1">MSSSSNSNSNQQSNVPPSTPHQDTDSTDQTPTTPTLTTQNFPTSPTTAFPTPPPSLSANPQSPLDQFFSRYPTFTPTPTTVPPPANWSIHHDFAQLSEHKKWIPGSRPQSRANTRFRQALIDEFNHMFGMNDSDLENWQRLCRVVGVPEERIPGSITQCRKTLSTIHVNLIDLIETRYVGRGIPQRFPTLAALGKYTRDTGKFFPREAKSGGILGRLLRELNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP69</accession>
    <name>A0A2T6ZP69_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000158">
        <property type="protein sequence ID" value="PUU77224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP69"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP69"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="616" mass="67487" checksum="1CF51F088BC6536D" modified="2018-07-18" version="1">MGTEKIAPKRHIAIKTYIIQLHPRVGLVPLLPFFPEEPVENPVEKPVEWHVERVEQRVVKLVQETAEDFVEEFVEDLAKGLEEELVEDVEDLVEDLAVDPVEEIVEEPVEELAEGTGEERVDLVEDPAGELVEDPVEDPVENPVEDQEGLAEDLVGETVEGPVEKPAEEPIEDLAEEPVEDVEGLVEDLAVEPVGEPVEDLVEDLVGELGEELVEELVENPAENLGQDPEKEPVEEPVDLAEGPAEGTVEDLAEEPVEGSVECPVEKLVQDLEDLAEGVVDGSGEDLAEESVEELVEEPVEKPVEDSRDLAEDLEEETGEGTEANPAEESADDPVNDLAREPVDDVQDLVDNLAVEPVEETVEDPVEDLPEGTAGGPVEGVVEEPPPVEGFVEEAAEKLVEDREDSVKDLGEDIGEETVEETVEETVEDLVENPAESPVEDLAYGPVEELVQDPVEEPVGDVEEELVWELVGELEENLVEQLAERTVEEAVDFVEDPVEEPVEGSVEKPVEGSRYLAEDLEEEPVEETETNPAEESADDPVNDLAREPVDDVQDLADNPAVEPAEKPVEELVEDPAEEPARRPVGPQAPRPVLEYPKYLLSQALPPILRLSTGHCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPH4</accession>
    <name>A0A2T6ZPH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPH4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015458151" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="99" mass="10983" checksum="9577BED496F0BC7B" modified="2018-07-18" version="1">MASLRSLYFIFVILFFASPVLSRRHHRVSDRLANQVASLTIVGRKGTNWGGGGCTVLYSYGSGMYCLIFVGVAFDENLLYDTQHTCLALTRHHAALTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPJ3</accession>
    <name>A0A2T6ZPJ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1086274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPJ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPJ3"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="62"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="480" mass="52662" checksum="6B20789F6282A65C" modified="2018-07-18" version="1">MPAAELSIPDGPSHHGNPFAKLIWNQKIIVIPSFTLESGVTIRKVPVAYKTAGRLNEEADNTMLICHALTGSADVEDWWGPLVGPGRAFDWGRFFVVCCNSLGSPYGSASPCTMNPETGRIYGPEFPLTTIRDDVNIHKIVLDYLGVRSIAVAIGGSMGGMLVLEWAYFGREYVRSIVALATSSRHSAWCISWGEAQRQSIYSDPKYAEGYYPFDDPPTTGLGAARMSALLTYRSRNSFESRFGRNTPDPARHPYINSQAQRSPTTPSEEHWAVHNEGFRNARRLSSSPSSPTTETFPESQETSTASSSGSTTPSSSVGPPIKKHVPTYFSAQSYLRYQGDKFVKRFDANCYIAITRKLDTHDVSRGRTDGDVHAALQMLQQPALIIGIESDGLFTYAEQQELAKVIPNARIATIDSPEGHDAFLLQFEEVNTHILGFLREVMPEVMGREPICTTDKIGDGEIGAVKAGTVGEVDDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPK5</accession>
    <name>A0A2T6ZPK5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_987025</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZPK5"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="10">
        <location>
            <begin position="658"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="11">
        <location>
            <begin position="1259"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1494"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1494"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1509"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1545" mass="175203" checksum="8BF5E1C6A5E34C9C" modified="2018-07-18" version="1">MAPPAVMSRHRAENAQPVPSSGSTLNPRANPYLAVSPVSQLPLSTREGVQQTATSVRNSDQPTRSILTNTASRPASIRTAPLRRNPISSRRGYLGPLGRRGPTRPRNNDESHRRFYNDRALPMLTSLPSRTEIPALPRSVPRNTRDRGDVGQGYHSDRENGRPSYSNSHPNPRTDPNNHFLSENMIPMGPGINIPNGNNSYSSRGLPILMRNDWKKTDEISIKISGIPLSLDLYQLYNIFSEHGEVEYLELYQNDSGISDGNGRVKLSNVERPFWEEPFNYSLGIKGPDGSLKLRLETQQKHRTIQSPVDRQKSYPQKYVFKLSLLQFGILYQEDTMVPMFTTADQDEANLEVDLYRRTLDIVFKIWLKKDTSANANPQPEDVEEGDGDYDDDGSNTPKNKPTERFERYRFRIPFIHLEQLIEVETLSTSGRAFLIDLPSAPFFWRKLHDPRLSIDDRVKFWTSWNAWFRQTSITFDNSARNGLPVSLEQRGQTINIGRWTTYRFEVGAREAESDGFNDMTSALKDFNIKINARKDFKTLSMEIDPIWDYIGIQRIQYSDSSLRELQASSPLLSYPVRYQLEVCISHNCLNEYNITPPFIDRLAALPVKEAIPLLEHVAEKRIRYYDPMDIFILQGVTGSTFHLRLPDHCQLLRKANVTPSTVYFTTPTVEITNRVVRQYSEHIDRFLRVQFVDEKFQGRINSTDKKTMHEVFTRVKAALDHGITIGDRKFEFLAFGNSQIREHGAYFFASTDHLTAADIRAWMGSFKEIRIVAKHAARLGQCFSTTRAISGVRVDVRTTEDIVNAKGYNFSDGVGKISEFLARLITTELRLKLVDKEPAPSCFQFRLGGRKGVLAVSPDANHREVYIRPSQLKFEAKHNILEVIRWSKFATAALNRQLIIVLTSLGAPDRYFEDKLQFMLKSYEEAMVDPGVAVRLLCKNVDPNESTLAIAAMIRAGFMARREPFVMSMLKLWRAWTIKYLKEKAKIMVEEGAFVLGVVDETGTLDGYYDPQDGSAKDADNPETSLPQIFLQVTDPDRPGESRIIEGPCVIARNPSLHPGDVRKVMAVNAKELHHLRNVVVFSQKGDRDLPNMLSGGDLDGDDYIIIWDKMLTSCISNYEPMNYSAQAPRELARDVEIGDITKFFVNYMRNDKLGTIANAHLAWADKLDEGVKSDECFRLAILHSDAVDYVKSGEPAIMPPELRRKTFPHFMEKEPEKTYRSDKILGVLYDSVSKIDFVPAFELEFDDRILSAYTLNEEILEVARAIKTRYDAAMRRIMAQHDIYTEFEVISTFIMHHSMATKDYKFHEDIANICNGLKDTFKKIIYEVVASKDDIIMGPFIAAMYSVTHQEMAKAKKKFFAAKAKKAVKRAAKRASGNEKAQGEGNIPAGTKGLEELAEFTIEEARDMPLISFPWLFGRTLSRIANREYPFRKLDGSPVDFKQAVAVTDELEGRMGKKKHATYRHGIYDDAVAITTPGTQGNGNDIPDNFWNGESSLGVSQRETNPKDVTTTTNNTTPATRTPTINTSPDSNTVYHSGEVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPZ1</accession>
    <name>A0A2T6ZPZ1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1193975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPZ1"/>
    <dbReference type="OrthoDB" id="5393450at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47345" checksum="F228176F84ABFCA2" modified="2018-07-18" version="1">MDYSSNFNPLFNSTTTSNNNSTFANSVFDASVTVPDFTKEKKFTEWHKKQGIPAPQDYPSFANQPSPFSTLRQNPNPPTAASSYIHKVSTLQPATDARASLLEADAHGGLNEPLEGRRKSTLKKTLSSSPPGSPSGHWPRNTFGSRPTSRTRNRSSSMTDDQPLHTADTNAPPLLSIYDSMPFDPAPLESKPADATFTPTQVRVANFSEDRFPDLIRSLRRYYGVILEPYSGLPENESKFHDPDIVPREQLDAKTLRKTQPLAGADGGPGHWVRITFGEREAAERAVAGSTKGELVIGGRTIIITFWTEDPIIDNPLPYTSSQMDIDPPPAPLRRSSSQPLTSPRPLRRVPTGFEEPALGGGEGGNVYSEHMPGAKIVVPKPVEFAKNEGWFSGLAGSLVSGPKAVVAGGQKGGGGGWSLPSVYGYVMDDLVGMKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ43</accession>
    <name>A0A2T6ZQ43_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1085838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ43"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ43"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="234" mass="26868" checksum="CC2642D003D0BAE7" modified="2018-07-18" version="1" fragment="single">KIIQRMNMKITRRDLLSGQFGPNGPGMTIPELSGQARTIITAGSETTATFLSGTTYHLLKNPRVYNLLVEEILSAYSTYEDITDTNAWRLKYLSAVMDEGFRIYPPIGAGIYRERMKKTVEPSTSSWSTCRSPENFHNPDEFKPERWLDPDCTDKKHASQPFSLGSRVYIGRNLALKEIRLVLSKMLWVYDMELVNKSLDLDRDSTSYVLWGKPEIWVRFARRRGAHVPLLDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRI1</accession>
    <name>A0A2T6ZRI1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1101536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRI1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRI1"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049205">
        <property type="entry name" value="Vps3844_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21656">
        <property type="entry name" value="DUF6859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015481059" evidence="3">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 N-terminal" evidence="5">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="4">
        <location>
            <begin position="308"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="410" mass="44283" checksum="3848B5C6726C27AE" modified="2018-07-18" version="1">MRILPGLVASCFAGVAASSTVYELYHDHSGDATSVSPEELALSLSEHLGVSRYHKLGPQGNPLRLELDGGKSKMFQERVKEDFVLSIAGAYGIGATQPESTRIGLRDMPKISAFGELMDIFVRENREFLEAAVPRVVDMSPWGGMCVGVSENEISLDPKEYTPTVEVSGGDYGTPSEAADLFREYGIIKKIAERDIRSLPGQYLASCHAVGVEKYIKRYGPQSKQALNAAQLYLSLIDDIPAHIRSTILLLPVTKSNTGVSAFKIDLHKVYKRSEEEPLSLTAHSPPSAEATSTSKNPKRILGPISRCYSSKNSCTSATNACSGRGECVKSRFPTDCWVCTCKGDDGKKTDKWAGAACQKEDISVPFNLFLVFGIVIILVSVWAVGLLYSIGDEPLPSVLSAGVAPAKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRL1</accession>
    <name>A0A2T6ZRL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1084798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRL1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="7848" checksum="29489E57A2635800" modified="2018-07-18" version="1">MQHIARPTVGSTLLTLSHSLAGGILCAACGYSRALVGAFGNSRKSTSVLLTPVFGFLSTAGCMACSVPCPPEFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRV1</accession>
    <name>A0A2T6ZRV1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1084578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRV1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="12353" checksum="A96545EEAD0C1E5E" modified="2018-07-18" version="1" fragment="single">MQVLMHRYVKVCTLSLTWWWFASNLVSGGRREARRTRSTSTPRVASVRPITSAGVAVVRDERPSSTRALSSLPPKIIGLSWWVGWVMGQSGMDGSRWTLSSLLLAPFPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT11</accession>
    <name>A0A2T6ZT11_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_56687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000113">
        <property type="protein sequence ID" value="PUU78632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT11"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT11"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="298" mass="32198" checksum="B48EBEB662A5D602" modified="2018-07-18" version="1">MRKSGYESIYYNVSICESTGTAAEAKMAPRKRRKRADNIGVNKYPGDHLSDPMTQDQATKELSIIETEKQTVGDHVGSGMNKNVIENRQSDTNGDGTRSEARDKNTEVAASGALPGGEFNSHKSEPLSPNESISLQSAQRTTLFVSPSPAMIASGERFTEDSHSKAIPVAKPLAGKTASPDCVPSADRTGGQRANPKPVEKPQERDITGVPLAITNEPPQSHGKGHFSVPQARVNGEERADEADLEPYQSTRRQFMAGVLHCLSFARNSYSAREICYAPFQILMGLTPAARLGVMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT17</accession>
    <name>A0A2T6ZT17_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_55688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000112">
        <property type="protein sequence ID" value="PUU78639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT17"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT17"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="20301" checksum="851849BA2F49D538" modified="2018-07-18" version="1">MQNLVDSLHFLSSFDDLKIISNPTIIKLSPADPTSELETLQQMLQFLSGAIAMSKIHSPFRICLSFLYMTCLVRFLRVLALYATVERIGNVRALHYSNRVRTIPLWLAYTAFDFVTVLITFVCAIIYVAATNDIWFHAGYLFLGILGYWLEFVLLTYNVSLMAGSQLSAFGIVTSTVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTC7</accession>
    <name>A0A2T6ZTC7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hemolysin-III related-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_981786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTC7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTC7"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="33644" checksum="B5566D1A9CB26817" modified="2018-07-18" version="1">MAVKNRNRQRGAGGSTGEIVTEAAKNAEKKVEEALTVLLHELPSWMQDNHFIVSGYRPQSFSFYKSFHSLTYLHNETVNIYTHLLPALLFLLFGTYALQVHILPRYPTSTAPDLLSFTCFFASAGICLGIPAIATIGNKLDYLGIIILIMGSFIPSVHYAFYCHRRLAYAYWSMISFLGAGCATVSVMPAFRTPAWRPFRAGLFVGMGLSSVLPVLHGVWIYGGRGMDERMGMRWLIMEGLLYIAGAGIYAARVPERFAPRRFDLLGASHQVFHCLVVAAAVSHLVGLVKGFDYLHGRDAQVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTD0</accession>
    <name>A0A2T6ZTD0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1083463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTD0"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="904" mass="102456" checksum="BBD7E1372A0574FF" modified="2018-07-18" version="1">MEDQQILLQDALTIVRQQTALMRKCLETPGKLMDALKCSSTLVSELRTSSLGPKQYYELYMAVFDALRHLSLYLRESHPVNHLADLYELVQYAGNIVPRLYLMITVGTVYMSIEDAPVKEIMKDMMEMSRGVQHPIRGLFLRYYLSGQSRDYLPTGNSEGPEGNFQDSISFIITNFIEMNKLWVRLQHQGHSREREKRTQERKELQLLVGSNLVRLSQLVDLETYKNIILAPLLEQVVQCRDVLAQEYLLEVITQVFPDEFHLHTLDQFLSATARLNPNVNVKAIVIGIMDRLSAYAAREAESESPEEKLRKEEEAVQGLLKKLRLQEANNAEENKPADPAITDKKPPIMEANGNEGFKEVEDEGFKDGDDSTSPPADSTKPAEAPAEDINKDGDKGGDADKDSKTVDGSSAESTEKPPRGIPEDVKLYEIFFKQVLNLVNAQNLPIQDIIALLVSLANLALNIYPDRLEYVDQILSYTHKKVSEMANSADLHSPQCQQHILNLMLAPVKSYASLFTVLALPSYLPLLHTQSYPTRRSVAGVVAQNILKNQTKISTPEHAEGVFELLRVLIREGAQQQAGYPGAQAPRKGRDIETDETVEEQGRLARIVHLLCSDNNDTQFKLLQTARKAFNEGGDRIRYTTPALITSGIKLARRYKLREHYDNEWQTMSTALYKFLHQTVTSIYSRVGVPDLCLRLFLFCGQVSDQTEFEEVAYEFFAQAFTVYEEAISDSRAQFQAVCVIANALHSTRNFSKENYDTLITKCAQYGSKLLKKPDQCRAVYLVSHLWWAVEIPARSEDEKSPLYRDGKRVLECLQRALRVADACMDTAVSVELFVEILNRYVYYFDRQNEAVTVKYLNGLIELIQSNLSSNDSSTTETPRKHFERTLDYIASRDFAGVVLDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTE8</accession>
    <name>A0A2T6ZTE8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1141323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTE8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="153" mass="17063" checksum="BCDC95D083C4D55A" modified="2018-07-18" version="1">MTTAVIPSVETDGAVKAEMTPRFTEPTEAPGRSGGPSKSLRNRVGEGEDDDESTPIKKPKLLNKDFGACGIQPQIYTRRGPDDVMFDLMDKVHGILEAFDESENYPAGPKIAKECCRTLAHLMPIHILEVFVQTYLIKMRVEKKVRAFQSHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTH1</accession>
    <name>A0A2T6ZTH1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTH1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTH1"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="290" mass="32050" checksum="F2A57621EE5472EE" modified="2018-07-18" version="1">MPNPADSANLFVKNFDEDFISDPDELKKLLELYGPGEDEANAKVNLNGSIVGKKRLFVTYAERNEELTQRLKLHIKWKDGFRRDGKESDRSNPDSTNARSSDNGEDGSTEGTQKGEKVSIEKEPLSPPLEKSPNRREDGFDQDAIRESPEVSLIDEGSEQGSSTTGALTIDDRPPLTPVENVPHIMIEQDTTSLTGWHGSTQLTGSKFSHLELPLVSDNANYGIEVTEVDKEDVSTETTYGDNIAAYAEPTLPQIHGHVMDDISGQVQESDFHDQIREEMLQSYWAAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV32</accession>
    <name>A0A2T6ZV32_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">11.9 kDa wall protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1047172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000096">
        <property type="protein sequence ID" value="PUU79274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV32"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="13323" checksum="B1EB188DAF83BEE6" modified="2018-07-18" version="1">MSSKIVREPATKAVADGTYHIKNGGYYLAVNPDRQIIIQQTVYAWTVFVDGEYNYFKDPKTTHYLTDNGGQNVLSPKADVDGRWGNASVDIPTQLINAETERSLGVPYGTPSDTWILVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVZ9</accession>
    <name>A0A2T6ZVZ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1100707</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVZ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVZ9"/>
    <dbReference type="OrthoDB" id="1726119at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000224">
        <property type="entry name" value="DnaJ and TPR domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015719175" description="Tetratricopeptide repeat and J domain-containing co-chaperone DNJ1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="401"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU79655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="519" mass="57303" checksum="9AD533BE77D2594B" modified="2018-07-18" version="1">MIVRLGALALAATLFSGHLVVCDTAHDQPVQSLIESANALLAKGDMYGALDHFDAAIKKDPTNYLTIFKRGATYLSLGRSNQASVDFDAVLSLKPDFEAALLQRAKLKSRVGDWNAAKRDYNKVGGATGKERIVELEDAERGVNAAMEAGVKGDYEACVTHAGAAIMVASGLHSLRALRAECRLRRGEVHEAVGDLSHLVQLLPSNINPHLQIANLLYFSVNDYDRSVAQLRKCLHSDPDSKPCSKLFRRIKNLEKSVAKVRTLVEKRQYTSATRLLVGHAGETGLIDEVKEEVADIKKAGYYTSACPEDLLLWLLETTCEAYTETKNNKKATLYYTAALSLNPNSLPALLSKATIQLAEDLFEEAIQTLEHAKQTHPDSQPLLQKLQEAHTLLRRSKAKDYYKVLSVPRDASDREIKRAYRGLTKKYHPDKYRGELSQEEILKKMAAINEAYEVLSNGELRARFDAGDDPNEQDGRQAWGHGGHPFAGGQGFSGQQFMFRGGDGGQGNPFGEGFKFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWI6</accession>
    <name>A0A2T6ZWI6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1080732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000080">
        <property type="protein sequence ID" value="PUU79845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWI6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWI6"/>
    <dbReference type="OrthoDB" id="5286874at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="727" mass="81939" checksum="152245170E73E14D" modified="2018-07-18" version="1">MADPVASPAALPEPTQASEPAPESVGQPSLPSPPSQEPADPLDGWKKLITREEQGFYDEQDCLHPSYNLASEELKDRKEDDAVIFNYSLDTDYLGRVDGNPPAGGDPTSAGRISPDDDIFFRVSKDELLGSKQFDQIINPLKEARQSLTQGQRLGIIDFPQCYDTQESSLLNSMGEKLGLQRNGETTYMDKCLQGVPKLPAPGHFRTGISLRASFKEPTGLPKPGSSEDRFILFVSFPYVGESSNERGLDSERESIKLREFKRLGVGVRGREAPVGRGGSYDPKEISVEKGEILVHQAQYMIFDNYTMATFRSKEDSARGQVPLHRFQERIGAFRAVVHMIANRMDLELWTLGKLRDSLCQLEEDIDQMISDAKTYEDNQGMEITPDDNPQNLTPSIKEKLTTKERLKWDEDYDRARQNKVHKRKQRRVRDLLTALNRLSADLFAAISVAERQIAVLQDLYNIFLTSYRTKTKDYEKGYPLRRNPFHKNIVTIPILSENPEQIWPNTLDTIDEVVRERKFFIQEVKELVENMDIRRKILSAFLKSDQAKAAPSERTAQEATEAMKRTEKIIEETQAQLVQQGQTLTGFTIVTTAFLPLGFCTSYFGMQTIKEFGGPTPQMSLRKFWLTSGPVLAAILLFTVVVVLWKRPLAEKFKTSVKEKLGLSPREETDHAKEQRPVVGGAGPRVGRGLSWTRRKKTSDEEAPNPQESAPAQANSHEQQKVENGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWU4</accession>
    <name>A0A2T6ZWU4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sfi1 spindle body protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1107347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWU4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWU4"/>
    <dbReference type="OrthoDB" id="5215300at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="281"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="915"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="959" mass="112780" checksum="BF8C6C7A9463C6E6" modified="2018-07-18" version="1">MPPPPQDITGNAVASRQRYHYTAADLQILHEIVSLASVIPENRSFRAIWRAYDTVLAARQINPALDSVYFRFILQLQGAEGNTLYDKFMQLLDNQGVDISETRFLEIPAATSDYTRRRYEEAKQRRDRATGAYTASEEEEEGYTAEDEYGRQHVPPSLRRTSIEVRSSRRRSGSGSPREGAIRAAELAAETRREEVKRRKEQLAVGEYGLEASSIPDPPRVPENAADALYNLRMRAVLREYFHHWHLMTTQRVVRQRSLEQIAFLHDRRTLLRQAFDIWQEVRWFAVVERRAEVRYNSRLLASAFRLWIQKTAVIVQRSQEVRERILARKYFGAWRQVVVENNTKIRLFQLSGALLKWRNNLARKREMAAQAQEVFERNLAHRAYWTWFFKLCGMLGTRRSNEKLLLDKLSVWVDRTEEKIRMNRMAEAFFRRRTLQVVFEHWSFRTIKCLDQADIAADHREWSLARGAFEIWRRETRFTPILDAMVEFVNDRIGDTFFTVWRARARQSIEAEKMSRIRLLKPVFRNWRLRVRHNVMVERVDERVAISTLHEWVLHTRAREFRLHSERGLKADTLSHWVERFRSQGDKMENLCHEMTVRRNRRIAADALRMLRRKLRLVQLSESEARAIYRSNLVSRALVKWRAESDVYVQLDDWADDAVYYFTVRRTLRRWMRAFKESRKQRLRTAYRVAARKTKRNLAAKVMEVWKTKFNRIHGMNDTAQGFRRENVTSTALNIFQHWQTRAGGILSLAAQAEEASSLRIMRQHLVIWADRHDQNMELEEQARLFSEEATARAAIKYFSLWETKSWHLNMLRMTASRFERKRFKALFRMWRIRAQDNIDSRLEEQERTRILIPPGIDDTIEGDFGENWVPPLQPVVGQSSTPLGTPKPPRSSAVVMPAPWRTSTTTALARSRLFGRTPGGTPGGRLFGRTTDGAPASPLLRSTIRRSRELGRSRLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX57</accession>
    <name>A0A2T6ZX57_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_976205</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX57"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX57"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU80081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="877" mass="99712" checksum="6C2AB7CDEC7CC8C3" modified="2018-07-18" version="1">MSSLSNPPIPGNIPAPGIIEGPFRPKHRRTHTGFGVREIKAVEASIPQPLRETWRKLAASEFTGKESFQREVVRHVETTLARSIYNCDDNAAYSGTALAIRDNLVIKWNKTQQQQTLQDQKRVYYLSLEFLMGRTLDNAMLNTGLKDTAREGVSELGFRIEDIIDQEHDAALGNGGLGRLAACFLDSLATLNYPAWGYGLRYRYGIFKQEIINGFQAEVPDYWLDFNPWEFPRHDVAIDVMFYGVVNKTTDDDGKKKKVWEGGEIVQAIAYDVPIPGYGTDCTNNLRLWSSKPSGGEFDFGKFNSGDYEGSIRDQQRAETISAVLYPNDNIDAGKELRLKQQYFWVAASLHDIVRRFKKSHRPWKEFPDQVAIQLNDTHPTLAIVELQRIFIDIENLEWDEAWQIVTRTFGYTNHTVLPEALEKWSVPLVQNLLPRHLQIIYDINLFFLQSVERKFPKDRDLLRRVSVVEEGTPQVLRMAYLAIIGSHKVNGVAELHSDLIKATIFKDFVDIFGQDKFTNVTNGITPRRWLHQANPKLSHLIASKVGSYDFLRDLTKLNVLEQSVDDKKFKKEWMEIKLAAKVKLAKYIKDTTQIAVNPHSLFDIQVKRIHEYKRQQMNIFGVIYRYLRLKEMTPEERKKQVPRTSIFGGKAAPGYWMAKTIIRLITAVGEVVNKDDEINGLLKVIFIEDYNVSKAEIIVPASDISEHISTAGTEASGTSNMKFVLNGGLIIGTCDGANIEITREIGEENIFLLGNLAEHVEDLRHQHRFGKDVAMDPKLREVCDAIEAGRFGPEVTYSGLIASLTIGFDYYLVSDDFSSYIATQDLVDEAYRDQDGWATKSITSVARMGFFSADRAINEYADEIWSIEPSDIKSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX60</accession>
    <name>A0A2T6ZX60_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1107289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX60"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX60"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="482" mass="54041" checksum="B345669327F467A6" modified="2018-07-18" version="1">MMASRVARIPHYTSPYLFSPRISPTLRFHPHQLPAFHVPLPQFQSSVPNYFRQGTQRGFSMWESPAWSRSSGHIHWQNFLKKCQKSHKWFSEKIKALLQTNFGLGLATIFAGSVSNVVYTQYTNRIREIKLQSALAMGAVPDIERKVNFVERLGATKAIESILKPHIDYEHYNMIVGNHGTGKTTLVRHVGHKLDGILYVSIRPNCASDKSFAEEMAKAFHWTSPTHFWLDRLLAYWGISTAATADDTRALLDRVFNEFHNQAKLFKIKNGRTPVLVLDNVNRLAQDNPKLLNVLQDMAKDAADDGTYITVFVTSEGKAPIQMLSRSSSSRLGKVMEIGDLNHEEAIDFLCNKRGISKSTSQEIYGLVGGRLGLLGSTINELHSGQNFTDVRTLLLTDAKKVLRNAGMDQKAQFEPIAKPIAQFILKHGRISLDDFYKIAGAQGDKLLSIDVFTNVPRTEWVFFDTRPMEIAVGALVGEAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX88</accession>
    <name>A0A2T6ZX88_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1080175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX88"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="92" mass="10885" checksum="CBEE0347393FD46C" modified="2018-07-18" version="1">MCVHRPNPGKKKNPRRASYHVQHRRNAWYLFLYGEGEEKKHAQYSTGTCSQRIRPLINDSSRQGVGIAIIAEENRKEKKRFPRIPSSRCWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXF0</accession>
    <name>A0A2T6ZXF0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1107215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXF0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXF0"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="33"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="607"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="694" mass="77143" checksum="4BD01AE7097A1571" modified="2018-07-18" version="1">MAQQASVNVNDPGLITLVNKLQDVFATVGVQNPIDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLVNRPAPARANGTSKEEAEMKSGDSAANLDEWGEFLHIPGQKFYDFNKIREEIVKETDAKTGRNQGISPLPIGLRIYSPNVLTLTLVDLPGMTRVPVGDQPKDIERQIKDMILKQISKNNAIILAVTAANTDLANSDGLKMAREVDPEGQRTIGVLTKIDLMDQGTDVVDILAGRIIPLRLGYVPVVNRGQRDIDSKKAISAALEHEKQFFEEHRAYRNKHAYCGTPYLARKLNMILMMHIKQTLPEIKGRIASSLQKYTAELSSLGDSLLGNSANIILNIITEFCNEYRTVLEGNNQELSSIELSGGARISFVFHELYANGVKAVDPFDQVKDIDIRTILYNSSGSSPALFVGTTAFELIVKQQIKRLEDPSLKCVSLVYDELVRILTQLLQKQLFRRYPSLKEKFHQVVIAFFKKAISPTNKLVTDLVAMEACYINTGHPDFLNGHRAMAIVHDRHNAAKPVQVDPKTGKPLPGGRDSPNPQALDSTPEGFFQSFFASKNKKKMAAMEPPPATLKASGTLSEREGIEVEVIKLLISSYYNIVRRTMIDMVPKAIMLNLVQLTKEEMQRELLENLYKSDELDALLKESDYTIRRRKECQQMVESLSRASEIVNTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXF8</accession>
    <name>A0A2T6ZXF8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IID, 18kD subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1192014</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXF8"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="314" mass="35623" checksum="0C47DEE776DB8A43" modified="2018-07-18" version="1">MSNDKFKYRVEIQQMMFVSGETGEPSAETTGIIEEIVRGQVIEMLQQCTNLASRRGSRSISTDDLIFLIRHDKAKVSRLRTYLSWKDVRKTAKDNDPSGGAGAPDPADILDDAAAGIAGGAGPVQMRQKKAKIGLPWEVASFFSEQVPEREEDEDEDEVEANAATLQRLKNADERTRGMTRDEYVHWSECRQASFTFRKGKRFREWAGFGTVTDAKPNDDIVDILGFLTFEIVQTLTEEALKVKELEDQVLLESREKSKKRKREKFLFHAEEGRTPIEPRHVEEAFRRLQVPKPKSRAMRNFSGGVVKSKLTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXS1</accession>
    <name>A0A2T6ZXS1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1079868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXS1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="85" mass="9167" checksum="815A53839CE735C8" modified="2018-07-18" version="1">MRVGCVAVLVVSKFGVGSAGWTRQGISGLRSARAREVLKKQKGFADDIVMFGSVLCCRPLLFSLLISLFFLLFSKQLNAGVGKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXU6</accession>
    <name>A0A2T6ZXU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXU6"/>
    <dbReference type="OrthoDB" id="10594978at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="17179" checksum="7A7B7FFE4FA324F9" modified="2018-07-18" version="1">MSPTLRSASGPVVGHIPSVPGSPSHLRTWLFDAETSDDSSSEAFSINPPSTTSTTSTKPGSELETIIDSECEFDCETPTPGVITTSTHEERAVTELETESNHDSELPNTPRPETPISDIGPEPELRGCYNPLPFGRYLQQVTSFSIVILLSRICTNNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY59</accession>
    <name>A0A2T6ZY59_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1123666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY59"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6450" checksum="3D6BB1CC909044A0" modified="2018-07-18" version="1">MVDTLIQSSPIDLWRSLYNNFVHLGIYTLYRDEVKVFIVTSAFLSIMVFSTGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ15</accession>
    <name>A0A2T6ZZ15_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tropomyosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1078990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ15"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ15"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="18858" checksum="4492A08482A4748F" modified="2018-07-18" version="1">MEKVKEKMIALRAEVDDVQAKNDELQAKIKVLEQENLQKEQEITSLNHQKNLLEQDVEKLETRLKEEKEAHVIGSNNSQEMQNLQRKVQLLEEEAEEAEKNLRETNEKLRLTDVKAEHYERKVATVEAERDALEKKYEDALEERKKAAHELEDLQSQLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZG2</accession>
    <name>A0A2T6ZZG2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1078465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZZG2"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1552" mass="175643" checksum="697AB221B8B3D9F1" modified="2018-07-18" version="1">MPLPNILRKQTPVLVSLLLRRSIKPYVLIAGSSGRTFTNSFYRRNSTPTDSPPVPNLPESESEPLPLLSDVTGSFDETPPEEAAGERGDDVSSRDTNTRLRKVFIDHRPRRSIFRPVLSGRLRIRRRNYALSEPPAEQVRQVGDFTFRRITSEGVAKVGRVHRIPVSMVEGDVDPTRPGLEGLLVRIEGAFNCNVYISPEYMVEEWNFWKYEDKRTVKGESPLTRDLGIQMTKLTAKEMHTYWLAQKCLGGQPTPELELVQRLVKKTQRLYMKDSTGLKDTIEISRYSRNVKRIIESPVDEGIRFETWRGPDSVLSRLDALTEVTNMGQKVIFQMEKYLDYLSGRGVDDRSGKPGQTRDFANFMLRNALLCSDRNDSNIKTFLNTPKDQEIVEYSALSKTHHLPRLQVLSKISQSVGSLLGLADMGIKHLLRQKWSQTELALEAYEKLLDRIYRNTESLTNAPIGGSDEGLGIPFYGKDRYTTQRYTRVQVASRIIQQHQKAIFLARERLGVSPLRGRPMIRRVELRTPQTHPFPGSRFLSFGGARRYSTVAPQPSGSMPGVPMGPPQISKTRTNSIRERFEAVETLQRNVLNGIGLNPVMKDLSVEVVPSVDSTDDTLGHNWESVGDMSDFLEASAAKPLEIGDLSEVRSGNQAELGLYLRPTPGGQPTSDFLMTSGNIAQRQLPRITFSVPGFAPKAKVERFILYYDQMIKAMNKNGGPPVDPDDVAAPRSITEEILDPVRRFEEAAARLYAEHRPAFDGIHAKCADETEERNITLSEAAEMAFDINYDPNSKEMLYAVHTALMGDGLHFMGDRGMHRATNLFRVRSKKDIRMIDSVTKLIRKTADEQQSTGKFGRTAAEDTGRKIMAKFIEKANYLIDLSREYEKEVLMGRRKGRPLVEMEEIKELEWDENDKFFIEYVKARVLKYGLQKTPIDGLAPVILRATNRYGEVLDALTADTFLREIGAWSKWENTSLHQSGLDLPGLGRSKLGDEDENKLQLWVQEGEIKNFGFEDVLRAVRKDWGGMEVFTIDDPDAHEIDDGISLERVSDTENWVHVHIANPAAFIPEDHGIAKIAERRATAHYLPDKFYSMLPEAITGAFLGVAPDKPVMSISIKVNDNAEILDYKIQAGFVQNVRRTTYDAVDLALGSYRTIEFKADITIGEFPRGQRVTQGVERRTTRDIKRDAKRDAKRDAKRDAKRGAKRDAKQNVNRDAKRDAERGAGREAEPFTPHQLCDLQKLRDIALALRRRRTRDGLIVASSMDLQVEVDSGLGSQNHPYNSSYPVLYRGHPAVRLTVADSMDVELRDSQLMVSEMMSLANNVASIWSCERGLAMPYRVMEYDYRRPDVVKAIEEIVLPQRTDLGRPPFESTIRWLMLLGQTRLQARPGPHMLMGLPTGYTKTTSPLRRYSDMLAQYQIQSVLLNQPPKTITELEPILSGLQRTEQTAKHIAKEANRLWSAIAIKRAWEIGLEKYTFPEKLSFLVMEKHSPPTPCTGFVRELGLVAKMCFADKRDEGKVQVGDVVGVRLRDVNLSERYVWFEFTGVVEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A033</accession>
    <name>A0A2T7A033_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_972524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A033"/>
    <dbReference type="STRING" id="42251.A0A2T7A033"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015518669" evidence="1">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="18940" checksum="D906942591A51D10" modified="2018-07-18" version="1">MKFTLIAAVSVLSTLVSGLALPNLVPRSTVFQPNVAVVIKEDFPTTSFPTTTAEVGRSNGQHNMKTLLAFVIPPCSGTCTVSFDGASSATGSQRMQFFTLGYPPSAGNTWNSKPYTDIHKGTFQTAGSSTGTVVEDFGLTFNCPSVITNYGFEVQPVWDNDYVTWDTTTAGYIITCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A196</accession>
    <name>A0A2T7A196_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bestrophin/UPF0187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1077107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A196"/>
    <dbReference type="STRING" id="42251.A0A2T7A196"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF16">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="265" mass="29398" checksum="86D65785E2F7D05B" modified="2018-07-18" version="1">MSPLPTHTNGAGARKATFPLSNSSRQKPRKWPLALRFTKGAIHHVILIPVLLHTLFTVAVVLVHRLLNVDLALPSSIVPSLSIVVGLMLVFRNSSSYERYWGGRTALQQIVNNIRNLVRSFLVCGPLSDESDKIETEKTVKTLVAMLYAVKNHLRGNWEAPAFQPEFASLMPKGFRGHEAEGVGLPMELAFVVERYIKRGVAKEAFNAPQSANLNASLNAVIMAYGNMETIKLTPIPVCQQIHQKQVLALYCCILPFCLLDDMGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1M1</accession>
    <name>A0A2T7A1M1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1019224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1M1"/>
    <dbReference type="STRING" id="42251.A0A2T7A1M1"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="686" mass="75308" checksum="586864AC1ED51BD5" modified="2018-07-18" version="1">MTGSPHAFHRIPKDLEVPYLLPKNRPTRNRGASPPQGHNHDHNSIATTDLNLRGGITAQGLAGEGPSGLRSASRKNQRALPIGAADLKTRIEMSQVSSDPSRTQSPASSAFPSYFRRERNTLAVESLPELPNSRGYSSEQNREEDRRDSGGEGTGKRKDAVYYAPIPEKQKLGYLSTAALIINKMIGTGIFSKPSSILEQTGSKGGALFLWATGGVMTLTGLFVYLEFGVALPFNGGELVYLDETYPRPRYLASCMFAVFFVLLGNTAANTIAFAKQMLLAFHPEKNPDYRLQRFVALVCITFICLIHLFSRKMGIFMNNALAAYKVGLLLFVVISGFVCLGGGGGGDHSNTKYGAENLKDAFKGSSGSPHDYASAMLSVLYSYQGWENANYVLAEVRRPRGDESRTFKRAALVAFSVVTLLYILANVAYFAASTTDEITNQGLTVAASFFIRVFGDGPFVARGLKVLIALSAFGNVLAVTYTNARVKQEIAKQRILPFSAFWASVSPYGTPVGALILHWIFTVIVIVATPNYSDNDEAYNLISVLFTYGHTWIGIFVSFGLITLPFHEKFQEWRPSIVGIKKLYALVALYVTLNVFVIVLIWWPVKTTHISSYVTPAVGTAVLAFGVLYWVGFAGILPALGYHIDSEPDELIDGSRVVTYKRYKTGPALAVADWWERVSKKRQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Z9</accession>
    <name>A0A2T7A1Z9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1062397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000040">
        <property type="protein sequence ID" value="PUU81769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Z9"/>
    <dbReference type="OrthoDB" id="5395290at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="387" mass="42756" checksum="BA914612B137D284" modified="2018-07-18" version="1">MPTPTIDDMIYTLSALGLYYVSLHATTGKRIELCYSKNHPCTLDETAYVTKLLFATATNPTSSTHTKLTDLFHLVLCNCKNKIIARLHKLCNRLRDLAKQDDCSFATLNPRPRGTRNPVATVATQCDAKIRTLVGTERFPLGSSLADFLNSVHEPSGLEPPSSHQELPRDLSRRGIVATQPEISWRLVNNTILEEMEPQAVSTLDITLLHPIRKLGDYHAAISVLINEIAKLNSCHECGVSIKEIIPLPPDTQFSGDFLAILNECAQDIGTTEVTMGDLSKAYRRMGELPEAPVAAPVAGLTASIHCECPVALAFVKSRFHSPVPTILVIGISKFLCWLCREFLATLHHFYPHITIHVPPCSGKLRSRWTLPPGAPSEVVKAMRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2A9</accession>
    <name>A0A2T7A2A9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_544796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2A9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="137" mass="15440" checksum="3CC7346D12B5A868" modified="2018-07-18" version="1">MVFPTTRIRMTLVNTTAIAYTNTMRLRPIFCSYAITVVFTNVMCLRADRGSPQRGLTNVGSKFPLMSMRFLLVPWLCVRLSFVDPSSSLQRVSGGASRELTKLKSGALTYLGNPERIYAEFLLYIMAILSDTHFVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A313</accession>
    <name>A0A2T7A313_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1099408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A313"/>
    <dbReference type="OrthoDB" id="5374171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16964" checksum="C042C2D1694D13A6" modified="2018-07-18" version="1">MTVLSAQRIFPQKSFHVAPGDWSVPGEVEYGWQDLRCDVSDGKCTLAYVCETLKPKINTQVSWLKALAGASNIFECSDVQALQAAGNPAIFWGLIALSTERDSQPSQLIDVVNFKNWRRPSEEEHTGRIVVVEIYRDSRTPESESYEFPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A366</accession>
    <name>A0A2T7A366_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1075644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A366"/>
    <dbReference type="STRING" id="42251.A0A2T7A366"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="555" mass="60963" checksum="1EBD9827F7C7EF45" modified="2018-07-18" version="1">MNSDEFRAAAHSAIDQIIDYYDTIESRRVVSNVSPGYLKPLLPPGPPADPEPWADIQSDIESKILPGITHWQSPNFLAFFPANSSYPGILGELYSATFNSANFNWLCSPAATELETIVLDWLARLLNLPECFLSTSKNGGGGVIQGSASEAICTVIVAARERYLHSLATAGTSVEECEEVIDNNRSKLVALFSDQTHSSTQKGCQIAGVKYHSIKVPGSATENYVLTGPLLRKSLEELTVRGLHPFFLTVTLGTTGTCAVDDFASIVPVLKDYPNLWVHVDAAFAGAALILPQYQHIPAPFEHFDSFNMNMHKWLLTNFDCSCLYVKTRKHLIDALSIAPSYLRNPFSEQGLVTDYRDWQIPLGRRFRALKIWFVMRSYGVSGLQGHIRNSLRHGESFAQWVRDRADIFEIVVPPAFALTVFAVKTAVREESNCLTKVVYEAVNADGEIFITSTVIDGIYAIRVVGGGPKIREEVLRRAFSILVSKTEEMLKAEDAPKLNGVNDAKGVTKINGEDGENEIKLSGVSTIAEVEQGVKEVVQAGIPGIEILASAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3E2</accession>
    <name>A0A2T7A3E2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1099323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3E2"/>
    <dbReference type="STRING" id="42251.A0A2T7A3E2"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58975" checksum="75ECBC76009A77F4" modified="2018-07-18" version="1">MSSIPWSYHAALVQPSLVRDVELYAELQLPPANTSPPSNSIQRFVDDVHTGVMVTHDTRELCPSRTLMPPSDISYSNPGTNYQPSMSGYAESDSSSSGNHNSYSTLRSTGSPEEEGYPRQTFEVSPIYEYMSRRSDLDAPVDPNLAPSDTVCPKAVHISNGDDQGQEGHTDEEDEYRCPQTVPDIMYPFYEPRYYTYDQPPPIEAYSQQHDHSLNHDHSGSSAQCSRHNSPSRELKLKTQKHRRNKCPPGMMKPFAASPGEVEKTRKLRGEKPRGRGAGKKAKERKVCREHPAKVFNHASDYKKHMNQQHLRPFLCVFFFAGCTQTFGSKNEWKRHVNSQHLQLFYWHCDDSLCADRKAIFNRKDLFGQHLKRMHPPPAGSKSSAAAHMEAVIDRCRVERRQPPQHSRCGYCKQEFEGPQGWEQRMEHVGQHYEKNNYKEYSSDCWVPDEGLIKWALEHGIIEENNDGSYTIISTGKDAVVKAGVEQKKLAREEMAREYADDDLDFDAEGEDEYMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3P1</accession>
    <name>A0A2T7A3P1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin homology domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_968366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3P1"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotic expression up-regulated protein 6 PH" evidence="2">
        <location>
            <begin position="87"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="586" mass="62447" checksum="000176BDBB5C6393" modified="2018-07-18" version="1">MSDPVKPEDTKPVAAEPPKPAGTEEVAPVPETVAAPVTTSDDVTPVAADKPAEETAATEEKKEDDKPEPKEITQGTLSKFPSGLLAFFKTKRFFYFQDEPIPEDRLKVYLQKANSAHGIAAYASQTGKGLLLYSKAEGQSPHGIIKLADVTEVTSVGAAKFVLKIPNGGDLHFESPGERDSWVFTLRHKITEAKAIEEEIVSSDGYKATLEKLKNPTPIATAKAPEGPVETKEEKETGEAKPEEGAENRSASKNRKRTSVFGFRKKEKVEEKKEEKDEPKEEPGAVEPTTATTDAPAEVPVVAEAKEAEDAKPAEETKQAEKATEAPAAPKTAKRHSYFNVNVFNRGERKDKEVADDKKEEEAKPEPTEPKTEGEAAPAEVKPVDVVAPEASTAAEKSPASSPPKSRFYTGIFDRKSEKAEKEPETKPAEASTEPAAVPVIATDSTATPAEESTEATSPTTGPKEQKRKSSFFSPFKKEKKADDVKSDTEEGEPSSPKPSTSPVPKPGLLTLIRRASKAGKGKETESKEVVAPATVAEEVTPAATATTAETETPNGAPVATESDAIGEVVPETVAVGQGHAVQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3W9</accession>
    <name>A0A2T7A3W9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1041000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3W9"/>
    <dbReference type="STRING" id="42251.A0A2T7A3W9"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="21863" checksum="60EC3F9069BC19DD" modified="2018-07-18" version="1">MTSVPPNSNPTSKPPIVLSAPSGTGKSTLLTRLFAAHPQTFGFSISHTTRQPRSGETPGVDYHFVSPETFESLIAQGAFIEHTRFSGNYYGTSIEAVRAVAEKGRVCVLDIEMEGVKQVKRTDLGAKYVFLKPPSLEELRARLEGRGTETEESLGRRLERARVELGFAEVPGVHDKIIVNDDLDRAYEELEGYILGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A478</accession>
    <name>A0A2T7A478_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1074544</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="3 11"/>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A478"/>
    <dbReference type="STRING" id="42251.A0A2T7A478"/>
    <dbReference type="OrthoDB" id="60984at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000015">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000111">
        <property type="entry name" value="Glucose-6-phosphate 1-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429:SF0">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="6 11" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase NAD-binding" evidence="12">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-6-phosphate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="205"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="511" mass="58548" checksum="A77B72BA3DA36F7A" modified="2018-07-18" version="1">MADTIIQSHSGANPGTVELKKNTTIIVLGASGDLAKKKTFPALFGLHRNNFLPQDCKIVGYARTKMDGKEYLSRVKSYIKTPTKEMEEQLETFLKKCSYVSGQYDQDESFMRLREHLDDLEAGRPENHRIFYMALPPSVFTTVSQHLKKNCYPDRGIARLIVEKPFGKDLQSSRDLQKSLEPDWKEEEIFRIDHYLGKEMVKNLLILRFGNEFFGATWNRNHIDNIQITFKEPFGTEGRGGYFDDFGIIRDVMQNHLLQVLTIIGMERPISFSAEDIRDEKVRVLRGIPAIEPKNVIIGQYGKSLDGSKPGYLDDDTVPKDSRCPTFCALAVYIKNERWDGVPFILKAGKALNEQKTEIRIQFKDVTSGIFKDIPRNELVIRVQPNESVYIKMNSKLPGLSMQTAVTELDLTYRRRFSDLKIPEAYEALILDALKGDHSNFVRDDELDASWRIFTPLLHYLDENKEIIPMEYPYGSRGPAVLDDFTASYGYKFNDLGGYQWPVQSSAPHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A484</accession>
    <name>A0A2T7A484_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein G</fullName>
            <shortName evidence="9">snRNP-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1099108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A484"/>
    <dbReference type="STRING" id="42251.A0A2T7A484"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01719">
        <property type="entry name" value="Sm_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000019">
        <property type="entry name" value="Small nuclear ribonucleoprotein G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034098">
        <property type="entry name" value="Sm_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8555" checksum="7465DA31927BA5CC" modified="2018-07-18" version="1">MPQAQPELKKYLDKRLFVQLNGSRKVIGVLRGYDVFLNIVLDDAVEEKDGGEKVRIGTVVIRGNSVVMLEALERIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4E5</accession>
    <name>A0A2T7A4E5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_370688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4E5"/>
    <dbReference type="STRING" id="42251.A0A2T7A4E5"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="144" mass="16920" checksum="A85AA33EE6E99D94" modified="2018-07-18" version="1">MLNLQNTLDDAKAGKSELIKTKERVEAENHQRESDNRSLSTEKRNLHNEVEKLKGDIRDRSFTYKGNIRAREGQYRELEDQLDHIRQEYEDLQPSYQEKSEEVGRLQARLDERDGDIEGEFATLQRQVNNLKRERGRGSGEIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4M7</accession>
    <name>A0A2T7A4M7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1074283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4M7"/>
    <dbReference type="STRING" id="42251.A0A2T7A4M7"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="217"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU82701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="456" mass="50605" checksum="6C841DB42A91D5DE" modified="2018-07-18" version="1">MPGEQHQMSKKRILFIHPDLGIGGAERLVVDAAVGLQQRGHTVTVYTSHCDHGHCFDEARDGTLDVRVAGNTVIPPNLLGRFSILCAILRQLHLSLTLLLTNEISKYDYIFIDQLSAAIPLLRFFSPATKILFYCHFPDYLLATRTSFIKSLYRIPFDWFEGFTTGLADTIAVNSAFTKSVFATAFPRIRLVPKVVYPCVTPTTTSLSKAIDNDPPFPNDGRKIILSINRFERKKNIDLAITSYSLLTRIQRCQSRLVIAGGYDTRVSENVTYHSDLVALCEKLGLKAATSRNFISSLSVPEDTDVLFLLSIPAALKSYLLKTASLLVYTPAREHFGIVPLEAMIAGVPVLAHNSGGPLETIEEGKTGWLRPADDEQWTAVMRLALFELEEKAIVEMATRGRERVLELFSKEKMAERLDGEFDEISDKRSIRGLVWTILAGLGVGIGLGTAFALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4P3</accession>
    <name>A0A2T7A4P3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1074258</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4P3"/>
    <dbReference type="STRING" id="42251.A0A2T7A4P3"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000063">
        <property type="entry name" value="Rho GTPase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="56"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="452"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="645" mass="72827" checksum="C34E1A0817E9680C" modified="2018-07-18" version="1">MTSDQYHESVHSLHSNPGGHPPPANASLPYSNKGESEDMPALSPASQSPAEQEKLRKIDEILHSDIGVSSLLNRLKQSIAACKDFALFLKRRASLEEEHAQGLRKICRMTHESIRRPENRQGTYARSFEETTQIHERIAENGIQFSLALHQMHEDLAELSNNMERGRKHWKQVGLTVEKKLHEAELLVDKAKIKYDTAAEEWDRARSGDRRSGKTAFSLRGSRNGPRHEEDLQRKVATADSDYQNRVQLANTHRHEAVNSLRPQAVRALRDMIAECDAGLTVQLQRFAQFNEKLLLHNGLSVSPIKTDGADSGGAHSMRDVINMINNDKDFESFVLDLANKVPPQAMNQVRYERHPSINQQTPGVVTSPNSSAIAIQPQNYQANQPQGMHGHQPDHRDMMDQGQGSQQQPQGFGAVVQQAAILPTQHSMPNAEYSHSQYGMDYPRLRPVFGVPLEALLTRDESVVPIVVLQCVQAVDLYGLDVEGIYRLSGERKHVERIKQIFDNDSSSLDFRKREDFFYDVNSVASILKQFFRDLPEPLLTDALYQDFISASHIDDETMRRDSLHELINKLPDPNYATLRILILHLHRIQANSNVNRMSSNNLAICFGPTLMGSNTSPNIADATWQVRVIDTILQHCFSIFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Q0</accession>
    <name>A0A2T7A4Q0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Q0"/>
    <dbReference type="STRING" id="42251.A0A2T7A4Q0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="412" mass="44204" checksum="9325EE5C904B05C5" modified="2018-07-18" version="1">MSVVIKGISDIATVVLISDSPTLATALPLLLPDPPSNITTHVLTSTAYLTSTTSVTPTVTITINEVLDETLTTTSDTIHRDAIHTPIPFQAPAAALPPSTTHTTTTTTSVMVYSTLTYTETSVTAICSGARCPPTTTISPECGGTAYSWANKELELQGQALANCKARLASIASRDIVDCPALKEYNSARVAIKREIDYALGHRGSCRHYPIASMLTNDFVGLGVKLGFDIWTLVHGERAVKPPLWDRLLEPPPNPLGGIINNPLEGPNFGDGTTNFGTPMWEYQPPALQHPLVPPQQIHLLLTPLVENGNGNSKGNGSSNGNGGGKAFMTSINVMDLKRYDDGVRIVCTRVVTRNIQIVRPNVSEMNTSLWRLFGPSSRAIYENAISCDKAEAKPDEVYAGILADVMGLEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Y0</accession>
    <name>A0A2T7A4Y0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial outer membrane translocase complex, subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1120066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Y0"/>
    <dbReference type="STRING" id="42251.A0A2T7A4Y0"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="16388" checksum="E750D9E375D547D9" modified="2018-07-18" version="1">MVHIKEVEDQYFSEQRPGPDYDYDDYDYPHSSAPSSVGSDEEDGDEDDDYDESLYDRIVALKEMIPVHQRARIVDVFGKACTVLGGGLRFGGSVLWVVGTSALVLGVPFAVAIGEEQQQLDMERQATIMGGAAESLAPGAEDSVMPNKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5D2</accession>
    <name>A0A2T7A5D2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1061393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5D2"/>
    <dbReference type="STRING" id="42251.A0A2T7A5D2"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="630" mass="71009" checksum="E1B4AA3BCE09A726" modified="2018-07-18" version="1">MGHLDTNSSAPLDTNSTPKPSAGSIHQSSQALPPSPALAKESLDHFHGWKTIHGKQGFYDEEGFLYPSRNLTSEKLKDRKEDDVVIFNYSLSRTDESPPAEGSRPSPASFGEDDDIFFQMPKDTFIGSEQFNQVINPAKEPRPMQTRARLAIMDFPQCYDAYDDNLLNSMAKELHLPNPAAFSDAHSKRVLTLPGFGRFRTGFSLRAPSKNPSELAKPGSSEDRITLFVSFPYFGKSSSSIPLGPESESVQLLDFKHLGVEVPDRSTVVSERDKDTLGEILVHQARYMIFDNYTMAAFRSKEDSVKDQVPLNRFQERIGAFHAMIEMVSNRMDSELWALGKLQASLCKLHDQEEDIDQMVSDAEIYEDDQGMKRRQRRVQDLLTSLNRLSASLFAAMGVAERQIAVLQDLHGLFSTSCRTKTKDQGKEYPLRRNHFYKNIAPIPILSENSEQIWPNTLDAIDEVVCERKRFIRKIEALVDNMKLSTSLKSDQVRTAPSERTAQEARDAMKSIEEAVKKTQAETAQQGWAVDTFTLLNIAFLPLNFYASYFGMQTVKEFGGDTPKISLRKFWMNATPVVFTMVLLAATIIIWKRPYGAELRTYFQKKLGLSKEKINDVESPAPARVCSNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5V6</accession>
    <name>A0A2T7A5V6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1061271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5V6"/>
    <dbReference type="STRING" id="42251.A0A2T7A5V6"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="322" mass="36448" checksum="12808D8A3D46DCCE" modified="2018-07-18" version="1">MVNVPTIKLQPTGQEMPLVGLGLWKITNKTCADTVYNAIKTGYRLFDGAFDYGNEKEAGQGVKRAIDEGLVKREDLFIVSKLWNTCHEKERVKPIAKTQLEWWGLEYFDLFLIHFPVALEYVDPAVLYPSGWNTPDGSVKPIRVPIQETWQVMEELVDEGLVKNIGISNFQGSLILDLLRYCRIRPATLQIEHHPYLVQPDLIRLAKSEGIAITAYSSFGPSSFLELDWKKAFDTPTLFEHPAITTIAEKHSKTPAQVLLRWSTQRGVAVIPKSNSPDRLLENLDVTSFYLEESEIQAISGLDKNLRFNNPIDYLGTLPIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A633</accession>
    <name>A0A2T7A633_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A633"/>
    <dbReference type="OrthoDB" id="5290791at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37790" checksum="697D88096F696973" modified="2018-07-18" version="1">MVIDELDPPPKFDTLALLFSHYTIITEFAKMITTGDLIQLSRTSSTIRETLLQSRTHWERLVSLTSLECSEKDHIKGEKIKGCKICSMPVCETCIVRADFFGQNGTYSNRIRTFCDTCWSATDFSDTDLAAQDLFDYVAPVLCECVAKDGWLCSFCRAIERSELIYNKQVCATDGCDNPHDSSDKHRVCTWCQRPLPAAWRLTGEPNVLGRHLFNEDGTVRVDFADDSLEDGDSTSPMEDRGLRRAKSTDKIAGWDQEDEDSKARYKEAWLKKGARERERDREHQGEGSGSGQQEGKKASAAASEVEGVDGTGQKEDEQEPSGDEPSAGMENPPPYSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A687</accession>
    <name>A0A2T7A687_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_191313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A687"/>
    <dbReference type="STRING" id="42251.A0A2T7A687"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="55"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1064" mass="116644" checksum="1FC8009336498116" modified="2018-07-18" version="1">MLRARLHLHPHPPPSSQNKSPASLPCSYPVLHTVSTSSIDGASRTITLTPEDPTQPIGRSSRNKSKGLFAARNNGFFESAVMSRSHAEVRLLVPSRKIVIKDMKSMHGTYVNGLQLAGDETAELTDGTEVTFGSEVTRGDEIFPPKTFRCGVEWEEIPLPKPVAESEPTPETPKSRGGYGICEDLLISDYDPSEEGEEGDEEEREDELDSKYSKFHHLEEEKASGSGVSTSGTNSTVPRSGQTTCVGASTSYMIPDDELPISHERSTKDMSVESLTQSKDRVEQLKRKIDEMTGSGERDVVEVNAELVDIEICDAPARPGVTIGSLMNQAQEASVSRNDKSKDVMNESKGSNKPAPECLVIDDEESDIEIIPEEAFKRYQHISRTQEHTESEGVENSDMDESDDEDSSYRAHGRSRFNYVSSDESDENEEEEEEEELEDLEQDEEDEDQHDNDGEEHTGKASTANDTMDVTMAADNIYSPNAPRPMTPPEALSSKPQVAATPLGGVSQSKTNFAPFEELANAAVAAQNGSDSPNKSRGNAATSATISEPPTLPPLTMLPTEAVTKKTPSGASHIHWFPEDPHTPTDTFQKRYSNSSMEQKKEYFSARQINLANLANRPNDALPYLNPVRGNPKSPSVSQPLPPASLPWVQTFKTVEGPKEPTGLFPKVWEDRQQDSAQVPAPKGDKPPAPSPPPPTVTPQAKKLLEDAVAEGEKFRGLDKSTWWLGDEAEISIGEANEMVWDDEYCNDEDGEYDEEDEEEEEEEEDGNGSDNIPEQEMADEVVEYDEEEEGEGDVMEEEEDDTDSRHPTCAWFGQRKAFNTGYERFPVHHPNAMPTGRTSACEASRGDFSKSRGFSISNLVHENNGPLTPPGPLMVATASPPPPGPSTNGLISPPPTETKKEKSVADLLNPSSPHTGSKRKHSQLSDITPEEKSQEEEEIAHESPESMDETDDDVEDEDKLESITKVSTQELAMLFPGKNVQTLQAEMETITLEPALPTPNGTSDDEEEEVVQAREDEEEEERPRKRARTTRPKKQFAKFAATALAGAIVGGVGVFAALVASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6C6</accession>
    <name>A0A2T7A6C6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1119525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6C6"/>
    <dbReference type="STRING" id="42251.A0A2T7A6C6"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="660"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="782" mass="86946" checksum="1FF6CCB8FA084808" modified="2018-07-18" version="1">MSDFVFYQVKCDERPGSCSNCQKLEIDCPGYSPINSSEAPEEAVSAIFARAGRKRRRMVGSCVDCRASKSKCSSDRPTCERCAKRGITCEYDETLRGLSGGQSPKSRRDKKKTTASASDFGVEELPKYEGWASAILERRVSRSESEDRKGETEPDGTDWLFSPSLPKSSSHLNLLIETYFNDVHPCRSLSFLHKPTFMRSLQEGTIEKTYGTPLVLAMCALAAHIVYWDEVLEGRSLVIPDARNPSDQPSLSLIPGDQWAKKAQHIMITNFAEISPERLMALVLLCEHHSRTQQSRECFMLSAFLIRAAQALNLDIGQEDTPKAQDPDAVTECETRRRLMWSCYIIDLLLCSGVKRLMLWDPANIKAQLPCQERNYTLQIPCETESLYPKRTGSPGTRSSDNLGIEAYYIRLFYIRGKVLEEIRNPDPYAPPWSASSPFQNLTNDLVDWESTLPDSLIFNNSNVYARHECRQLGAFFGLHLVYHQVFCDLYRISLPGYHFPAAATFNRAPDGFVAQCQSTCNVHAARISEIFEMSFAHGWKALVEPLCSVISFESSKHQIVYFSACSSPGPERRKLWDALACNLAVNIKALNNIKGYSRAAGECVSSIQGLLERLNMSSILGPVPGYSEKRSTRPSEIVPGDIHNLHQFSTFRLIREGLAKPGSSSNREPPTPLRPGEHTLSNVRAVDTLQVVTSNPPNSHQILPPPLPPPMASNEQIALDSLGRPSEQQYQNIQADYEAAIWAEINFRVASESGQMFAWDPCFMNGGGIDGAGGSGAGGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6X6</accession>
    <name>A0A2T7A6X6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1119180</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6X6"/>
    <dbReference type="STRING" id="42251.A0A2T7A6X6"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU83487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="25787" checksum="7DDBC3C65AAAFE9A" modified="2018-07-18" version="1">MSGQAPPDAFIDAQKSLEYWNSVDATPNGMLGGFESVSRVDLVGSRTFIAKLKLPETPATSARPRVVDCGAGIGRVTKGFLSKLNGGRVCVDIVEPVEKFTDQARVNLKEEIDDGRIGEIYSVGLESWVPEEEAYWVIWNQWCLGHLQDQQLVDYLERCKAGIVPGGVIVVKENIAPDPDDIYDEADSSVTRTDPKLRTLFRQAGLKMVRTEVQRGLPKQLYQVRSYALKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A727</accession>
    <name>A0A2T7A727_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000010">
        <property type="protein sequence ID" value="PUU83529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A727"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="87" mass="9933" checksum="1810395715FB5C8C" modified="2018-07-18" version="1">MLEGYCRRPERVIGCLGNGFYSNGAMLISNALLPQLIYTSWHAGSWKLYLLNYHSLLSFSYTIFINHVAVPDNRLPILTIRDSGVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A867</accession>
    <name>A0A2T7A867_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1071526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A867"/>
    <dbReference type="STRING" id="42251.A0A2T7A867"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="60"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="494" mass="53873" checksum="CF3E1899C1BFFC42" modified="2018-07-18" version="1">MANVDSGRTTQTHSMESLSEHSGSLPSYGERQKLVGPLDWEGPNDPANPWNWPASKRWYGTLVPGSLCFLVTFASSVYVPGVYEVAAKFDVSITVALLGISMYVVGLGLGPMFSAPLSEVFGRKMVYFVNIPIFLLFTMGAGLAQNIQTLVICRMFSGIFGGPAVAVSAGSFVDIWDLKTSGSAVTVQAIASFMGPSLGPIVGGYLAQYEGWRWTLWIIVILGGALLVPLYFTEESYKPVVLKCRALSRGEELPPKPDPKTALKLIFTITLARPVMMLLTEPIVQAVAIYSAFAFAVLFGFFEAYPVTFEREYGFALGQTGLCFLGIACGLIIGCIIYLIQDRLVYVPALKKYNGSPPAEIRLVSAMIGSFLMPIGLFWFAWTARKEVHWISPVLAGIPFGCGLVLIFLTAILYILEVYPPLVAASAIAALGLLRYLMAMAFPLITVRLYHNLGIAWGTSLFGFIALAMAPIPWAFQRWGPQIRAMSKYNAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A876</accession>
    <name>A0A2T7A876_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_648211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A876"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="130" mass="15044" checksum="BB0B049BA4D0A938" modified="2018-07-18" version="1">MVGLVFSFFLSSLSCPFVFGFWGQIAIDIHLPALQRRERNSPIAFSIFLFEIEELVLFLSIFDCLLLGLSVCLSLTHSHSFPHALCYITLPAYHFPLPHFHHPLYSFTLFTFTFTLIFTYLGHLRKAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Q7</accession>
    <name>A0A2T7A8Q7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Q7"/>
    <dbReference type="OrthoDB" id="5415656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="313" mass="33093" checksum="D3BB24B273B315D7" modified="2018-07-18" version="1">MGGIAIANPSSPPTKLYVSHTPLQNAAVTINALANSEYLTHFPGIAPEDVSYANQIVQGLPSNICSSTHTFAFSTSTPMSLASSFEFTAYAALQNEVTAGAILRHWKIVKASRELNTPSPIVKGAGDCTKVWDALEKCWGRKVAEDAWFDYINGDKKEVGDSGDGESGGRKECADSGGSGNPGERPWKRTRPSLVANYNAVDRSGENENPREKSREQASPDSTPIDGVVGNSGGSEGPGEKSGKRVGLGQTPSTSAGSSPSAPPYTSGQRPHSLGRTFRAAYPMRYTDPIRSRSYPETAGAGPVGDPLELEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9G5</accession>
    <name>A0A2T7A9G5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrofolate synthetase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_960822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>7,8-dihydropteroate + L-glutamate + ATP = 7,8-dihydrofolate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9G5"/>
    <dbReference type="STRING" id="42251.A0A2T7A9G5"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU84363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="433" mass="46266" checksum="836DD975031F86FF" modified="2018-07-18" version="1">MIDLGLKRITRLVRDQGKFPWRAIHVAGTNGKGSVCAYISSCLKSSGIPSARFTSPHLVDRWDCITLNGAVVSEELFLVTEAAIKKKNAREGIGASEFEILTATAFEIFSREKVDLAVVEVGLGGRLDATNVIEPPVAAVITKIGLDHQALLGSTLEEIAREKGGVIKVGSRCIVDGTNEEKVLSVLGRMAEEVGVESFHAIRPEAVDREGEGGGSICEITTEAFGRQRFEGFLTGAYQPANLSCAVHALSYLSREYPSITASTVLDGVRNTSWPGRMDMVDLSCLFPGQGKRVLLDGAHNTQAALALSDYVTKELRAGGGFVSWTVSASKGKDIKEMLRILLRSGDKAVAVEFGSVDGMPWVAAASTEDIVSAIREVFGEEVEVIDGGKDVLGGVKMALKLAGEEGHTVVAGSLYLAGDLIRLLRRAEKECE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA37</accession>
    <name>A0A2T6ZA37_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1010606</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000561">
        <property type="protein sequence ID" value="PUU72361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA37"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA37"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="266"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="428" mass="46274" checksum="14DA37242616BB15" modified="2018-07-18" version="1">MYRVVAAAKPLQRTLVRRVSTNFNSHAGSGSSLEGYTPPTTSPANDMIAQLAAKHLDRLSLKDLIRFGRPPLSTQSLLTSARFTREYLPVRLSRRIRALRNLPYIIVSNPNISTIYNNYIDSLTAILAFPAASLTNLTEESRFTELLTEIVKTHSNTIPILAKGFLECRGYVTPEEATKFLDHHLRARIGTRLMAEQHIGLHLASVPQPPTVAVPGKSYIGTVDTELRPAEIIDSCASFVGDICEVRYGARPKLTIDGNPDVTFPYIPVHLEYIITELLKNAFRATIEANSPVPIIVTIAAAPGPPDAGGITIRIRDQGGGIAPDDLGYIWSYSFSTFDGSRSSIGSGNSGHLDDTDGGNAGSGMDVMGRFTESAGVLEPSSIAGLGYGLPMSRAYAQYFGGSLKVQSAYEWGTDVYLRLKGVGLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA41</accession>
    <name>A0A2T6ZA41_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Trimethyllysine dioxygenase</fullName>
            <ecNumber evidence="5">1.14.11.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Epsilon-trimethyllysine 2-oxoglutarate dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TML hydroxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">TML-alpha-ketoglutarate dioxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B9Z19DRAFT_1197650</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14181"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58100"/>
            <dbReference type="ChEBI" id="CHEBI:141499"/>
            <dbReference type="EC" id="1.14.11.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.8" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000592">
        <property type="protein sequence ID" value="PUU72294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA41"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA41"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050353">
        <property type="term" value="F:trimethyllysine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012776">
        <property type="entry name" value="Trimethyllysine_dOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02410">
        <property type="entry name" value="carnitine_TMLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="19">
        <location>
            <begin position="114"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="18">
        <location>
            <begin position="219"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PUU72294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="488" mass="55624" checksum="C560C1C6ACAAB8AE" modified="2018-07-18" version="1">MAAPRSITRILKSLPTSRNACSYHRRRSRASWLPAEVLAKRYSSNTATVAAAAASPSTEQTTSFPSPSPAPSGGNNSIINKQAQTTSDLPLKTYNVTKADARPKLSEHHKITFDEKKTLVPWEEGKTSHFQHVWMRDHCQCSECFHPETKQRVFDTFSVPKNIQPDIVEAEEKGMKIKWKNGGHESFYTWEWLHLHSYNPRLERYISPQFKFWGSEIAEGPPEVEYEDVMGSDAGVGEWTRKIRKYGFCYVNGVPVTPEATKELVERIAHIRHTHYGGFWDFTSDLSKKDTAYTTLALGVHTDTTYFSDPAGLQLFHLLSHTDGSGGQSILVDGFRAAKILREEDPTAYRILSNVRIPSHSSGNHDSSIQPYAPFPVFNHHPVHGELILVRWNNGDRATMDRWDDPADVGRFYEAARAWNDVLKRRENEYRDQLVPGRPLIFDNWRVLHGRAAFDGKRRLCGAYISRDDFMSRFVMSNSKREDVLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAI5</accession>
    <name>A0A2T6ZAI5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1009778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000528">
        <property type="protein sequence ID" value="PUU72483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAI5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAI5"/>
    <dbReference type="OrthoDB" id="5551751at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040200">
        <property type="entry name" value="Mug57-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28156:SF1">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YDR262W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="17916" checksum="ED05C213859963E0" modified="2018-07-18" version="1">MSTSTTDKPSGPPLLADVLPLDKSISIFSDLTRSVESISTRVSDSKTNTTVLAPTNYAISKLPRKPWEDPDDGGAGGNVLSEVYKGLGGEDRAGRNLRRFVEAHCLAENPWEEGVKVETLAGRAVWWAWEGGVKKIFPDGIEVEERMNEASNGQVWILKGVINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAR8</accession>
    <name>A0A2T6ZAR8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_927062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000499">
        <property type="protein sequence ID" value="PUU72592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAR8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAR8"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="211" mass="24119" checksum="49DFC8AD1838612E" modified="2018-07-18" version="1" fragment="single">ISEEQWLNLLCGIPTLEATPPTLQIPSQYSNHEFLTIYDIDSFIAKAKCLSVAKRGLRIQFSPSCLHNISSDIHLYSDVEERLLSGNISSHQVPLHHIPHFYLGLLPSSIHLPLYVFLPSLWNSSSPNSSYISNHHIQQWMDHALIPAILRHYPQDIIQHLPVSFNSASMSIFARGRESGTQSGRFESGKRQEHHYFLPGRFLKEVWEDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBD7</accession>
    <name>A0A2T6ZBD7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1008239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000469">
        <property type="protein sequence ID" value="PUU72756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBD7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBD7"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015526417" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="465" mass="51152" checksum="A9413BF2EB40D366" modified="2018-07-18" version="1">MLNSLALLSLFALEASAFWRLPCRQSLAVERVDPLVQFGQVGTHVHTIHGGNKFSQWSLEEDLLNSTCSSCQVKQDRSAYWTPALYFQDEAGNFNVVNQMGGMLVYYLPRGKNVKAFPEGFRMIAGDPLLRNFPYPDVEKSLWTAQDMTEAALRQKAIGFNCLNYDLPAEAALGMKTIPKNLSCKDGLRTEVFFPSCWNGKDLDSPDHKDHMRYPSLMDDGDCPKGFETRVVSLFFETIWDVNKFSGQKGRFMFSTGDPTGCGYHGDFMNAWDTKVLQEAIDVCTSPSGVIDECKIFDLYTEDEMHQCTIKPTVDEDVVGPLKKLPGCNPVTEGPESATKVDCPDEGLNDNQGSYSPKPKETQKAGSSEVAATPSSSSRTGPFKTSTPPAPPGYPKKEGAGVAPASYPTTTSDPYLVIVTVTETVTPLATTITIPTPPNQSPVLPDRKKRGLHNHHRFGGGHHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBT9</accession>
    <name>A0A2T6ZBT9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SURF4 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_597732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000437">
        <property type="protein sequence ID" value="PUU72960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBT9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBT9"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU72960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="34169" checksum="340DC9BBF17214A5" modified="2018-07-18" version="1">MAQIRGTANYHLGPDHRPFGGPSHSAATSDPSPLDAIREQTSKIEDLLDTFAEPVKPYLPAIGRFLIVVTFLEDALRIMTQWGDQLLYLHDYRRIPWGLTHLFLAANVVAMLICSVLVIARRHSEYAVGGLLGVVVTQALGYGLIFDLNFFLRNLSVMGGLLMVLSDSWHRKRFAFAGLPQIDEKDRKMYFQLAGRVLLIFLFIGFVFSGEWSVSRILVSLVGFVACVMVVVGFKAKWSAVLLVVILSIFNLIINNFWTLHPHHPQRDFAKYDFFQILSIVGGLVLLVNMGPGQFSVDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBV5</accession>
    <name>A0A2T6ZBV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1104145</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000438">
        <property type="protein sequence ID" value="PUU72949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBV5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="308"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="497"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="759"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="355"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU72949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="908" mass="98620" checksum="F78570D79FD31DF6" modified="2018-07-18" version="1">MVTAFQFFRGGGASPTSSAPGTPLLTSHVTTAQSSSTAPATPIAGPSPTTATALPELSCLSPLSRRQSPVLRTGSTPLAGSGNGTTTATSRSNAVASPRPQLPLNTAAAVSSSASNMLRAVAGSHLNNSLNFYLACAFCLVGKMGRAISNGLRILSDDDENLSGQTTPHPSGLDKRLPGILHGFSQVCSELLPFLRRNTTPLEPKLPPQYRKTVSFESNSCHFLSTSLSDMGFEGNQNKRLTGDIFSDGKDTPPATPRGTASTGSTLNGSTAATTPSTSRPNSTSTSNNNTAPMSPKPVSPGSGVSSASGAMNAAAHAAVVPPKGKMVVKIIEARNLRPSKDPYVVCTFESNEFISKGPRKSDDSGDGSDNEKAALAPGRGIAIPMKSRQSSSTSLSELQGGGSKKGITNPKWEHEAVFDVLGEQSEIDVSIYDRSNQECFLGHVRMCPLITREQQSGLDNWFALRPRTHHESVAGEIRLQISFERISKKHYGPDDFEVLRLIGKGTFGQVYQVRKKDTKRIYAMKVLSKKVIVQKKEVAHTLGERNILVRTATTDSPFIVGLKFSFQTPTDLYLVTDYMSGGELFWHLQKEGRFKEDRAKFYIAELILALEHLHNHDIVYRDLKPENILLDANGHIALCDFGLSKANLSANATTNTFCGTTEYLAPEVLLDELGYTKMVDFWSLGVLVFEMCCGWSPFYAEDTQQMYKNIAFGKVRFPRDALSLEGRNFVKGLLNRNPKHRLGATLDAKELKSHPFFNDVDWNELLRKNVIPPFKPTLSSETDTSNFDPEFTNAPMSQSLNARAAALASGNLAASTPLSPGMQANFRGFTFVDESSIDDHFLGRDELARMDEDAEDDWDVRHGHRRNNDDEDDARAFDGRGNRMSGIVKTGQADDEAGIFVNDGMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC72</accession>
    <name>A0A2T6ZC72_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome transmission fidelity protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1035588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000413">
        <property type="protein sequence ID" value="PUU73095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC72"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC72"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="145" mass="15926" checksum="25BD899D6730F428" modified="2018-07-18" version="1">MPSIPLHPTPYSPPPTPPSNPLPQLLHTPSGLAIVEIQGTINLPQQPPTTSSPDAQQRSYETPVGRLVFPDGDLTSSKLVYLYIGKHQRLTGEVKKLATPFGVLQRRDNTTSGGGAERGWEGEELEILEIVRWKVLFSQRPEPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCA7</accession>
    <name>A0A2T6ZCA7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1095739</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCA7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCA7"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="7">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="466"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="710"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1104" mass="121830" checksum="9CA5FFC4564F8C90" modified="2018-07-18" version="1">MPGVLGAASPLTEQLPKMSLTDTSISDYLSAVFSADSSQGSLDAALALCNAILSDPATAHHSFPTLFPPLAKAAADKKSGTRRESAMIVYGALYENFIPKSPVTEVLLLKETLPIVLDGLADKGAVVREASQYAIDAMLGLLREEALVAGLVRVLMVYVGGSGSKWQGRVAALQLIGKVAEKAVTRDGFLKEVMGRELQALIPVVESGMHDLRNEVSRAAVKAMTSLSKLLSNDDVARHIPTLIKTMSHPSKETLQKAIHDLSQTTFIAIVTSPVLSLLTPLLERSLSSPQTSQDVLRQTVVVVENLTKLVHDPVEAREFLPHLQPGVKKIEDTAALPVVRSLARDANATMVKAMGVGTRTNVPERISVSEVEKELIARVAVGADKKKLWEQDGVRRYIADMGRECIVAREFKRIPGCTTVYLEQFISQKDATRVAAEIEQWARDETLNRFGSGIGEVDDEHKHEVEIVNADFSLAYGGMMLLTHTNLKLYQGHRYGLCGRNGAGKSTLMRSISLGKLEGFPSKDELRTCFVEHKERDERDMSIVAYIRLALEENGDKSISEEEIVETLKSVGFEGERAEMNIGQLSGGWKMKLGLAEAMLKRAQVLLLDEPTNHLDVNNVRWLQNYLKSHTEITSLIVSHDSKFLDEVCTDIIHYEDKKLVYYKGNLSEFVKKRPEGKAYYSLDASSVSFKFPSPGLLTGVKSATRSIIKMSNVTYTYPSATKPSLYNITASLSLSSRVAVIGGNGAGKSTLVKLLTGEMVPQEGRVEKHPNLRVGYMAQQSLHHVQMNLEKTPSQYLQWRYSSGTDKEVAMKDTRLLSEADRKQLETPIDLGDGRGPRRIEALVGRQKWKKSFQYETKWANLMPKFNTMISRETLVENGFSKLVQDFDDAESAREGLGYRELDVASIEKHFEDVGLDKEIAMNNEIGGLSGGQKVKVVIAAAMWPRPHLLILDEPTNYLDRESLGALATAIKEFRGGVCLISHDAQFVSQLSNEEWHIEAGRMVKKTSNGSNMSLLLPLDLSSRPGSSAVSLASSAVSSAANTDVEDNNGEGMEFKSVKKGKKKKYTRAQLKEREVRRRLRYLEWLNSPKGTPKPVDTDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCK6</accession>
    <name>A0A2T6ZCK6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1035396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000403">
        <property type="protein sequence ID" value="PUU73199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCK6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCK6"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33534" checksum="08E43EBA58FF007D" modified="2018-07-18" version="1">MPRPNARNLLVTFDAFGTLFKPRLPVPLQYIAVAEEYGVTGLAEKQVNSSFKEAFAEGSKLFPNYGKSVGMRPAEWWERIIRRTLEPLVPDGLTVSIISDLIRRFSTSAGYELYGDVIPCLEFLQHFRSRQASFWPYGTVTVGIITNSDSRVVPILNSLSIGVRSSTSKTGWEEALWIDPKETPPPKRKPGRPRKKPLVEPKLEIDFVALSYDVGVEKPHHKIFREAERMAKECRNLEGPWTRIHLGDDVTKDYYGAKLAGWKAVLVCRDGNSPKNQGMVTVRDFRSIRQLCELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD70</accession>
    <name>A0A2T6ZD70_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1004450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000376">
        <property type="protein sequence ID" value="PUU73440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD70"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD70"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="448" mass="47244" checksum="A2E616A723204159" modified="2018-07-18" version="1">MSSNPFRKRASAERTRTSQDDPTPRQEPQTLTTSPNRSRASSWEVVDVPPPSPALQKRSPPPRPPSRNRRSGIPPPEAIADPFNPTTESPVSSDFGGDDDGDDIFTQEPTELGRPGTTSFPSAGSDGGYSVAKSGRQSLDADAFKRLMLTGQSSLSTPPTPGAGLTPLVVAPDSSTDTSSTSRQSIFDPIPEAADGLPDETPRTSNELDEGEERRQSKERTPKPKPPPPRARNRSGGRSPASPPSSAADIPSLTPPRPPSLHSISSERSLPPPPPPLPPVGSTSPILNETVSPPSPATSIISKKIAPSPPLSRRHSVQSNTNPLRPSTPAGGANTSKMKPPPPPIRRHKSTNSRASTTPLSALSVPPPPPPPPPSRRSRSSTANSYESAEEPPTTPPAKSSPLATAPEIPMVQGTETDILIDLEKLQREVDELRGKYEGKGVGPAVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDG3</accession>
    <name>A0A2T6ZDG3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1034722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000369">
        <property type="protein sequence ID" value="PUU73537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDG3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDG3"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="184" mass="20685" checksum="193D215230266159" modified="2018-07-18" version="1" fragment="single">MDHPPKTLTDQNPLPKLIIFDLDRTLWPYWIDTDPTPPLTLIPTTTTTPPTLRDAIGTPYPLFPTTLPLLTHLSSSGGAGGIKLAVASRTHTPALALQALDLYGLRQFFDFFEIYPGSKVRHMRRLREKSGVEFRDMLFFDDERRNREVCGLGVWFVLVGATGVDCGLVDEGVGEWRRERGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE10</accession>
    <name>A0A2T6ZE10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000349">
        <property type="protein sequence ID" value="PUU73737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE10"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015457384" evidence="2">
        <location>
            <begin position="25"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="365" mass="32004" checksum="FF5A3FC839CAC071" modified="2018-07-18" version="1">MRSSGNFILAKSITLASIVGIVAAQRSPSACTASGQCGSGDLGGTTINPPITSCSSCINNPLPTSSPAPIRVTSTTMNILTGSSKSDTSPLIPSSPAPIRVTPTPLNILTGSSKSDTTSPPAGGNPTSTGASGGGATTKSGSTPTGGTSSGSGSGSGSGSGSGSGSDSGSGSGSGSGSGSGGSSGSTPTGGASSGSGSGSGSGSGSGSGSGSGSGSGSGGSSGSTPTGGTGATTKSGSTPTGGVGSGSGIGSSSGSGPRGSSSSTPAGGIGATTKSGSTPTSGMGTTTKSDRTPTGSTGSGSGSGSGSGGGSGSGSGSGGSSGDTVAPAATTTAPGGSTGVAARNGGSVVAVVLLGSLVGLLGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEI8</accession>
    <name>A0A2T6ZEI8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP synthase regulation protein NCA2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1134199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000335">
        <property type="protein sequence ID" value="PUU73892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEI8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEI8"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="701" mass="78794" checksum="629A9492BB8F8C07" modified="2018-07-18" version="1">MTFVSDQLLHLDAQIDRLALDRLPLTFDSHPATPHSLPNQPSHLPPPTPRAIKLQNIIKSLSTTTSRTLLSPRRLVSLLKDATIPTNTYGSYEAELYETELEWLLLSKATIQTYGIVLNSLLEQTLPLSQDLFYWDEVASSYSYTALYSLQTAPERMWSFGREVVNDAMKRFKEREGMGFMGIGGHSRESLLGGENQSEREEARGKETLSATARRFYTLVQNSLRDRSLVEFQRVGALSPFSLARHEIRMKQASIKKLREMQASALGVLIGEGLSFGFEEEHEEWKVIVERAVLLMEKVVRNVSSVESTLDEFEETVFSLEGLGGKADDDEDDERGSRLSSRHYTSGSGGRVATSALEKQLQEILLRHLPAQSTASRALISTYGRPSIITRYWLPATAFLLSSSAILRIFVSRQAELKQWLQELGATAVDFWANWVVEPIRKIIGTIRHGEDSEVALMSRSSLKTDMESLERMVVDFAVDNPSTSLPEGSVVSPLTDAQIQAVRQAVHEGDLTPVLKSYEQELRAPFKGAIRGELLRALLIQIQKTKVDVEVAISGIDHLLKSQELVFGMVGLTPGLLVCVGVFWWAKHSTGKGRGRRSGQRSGEMVRTLRNIDRILTGSAAYRTGEHNDDRGGVLTYKEHGLLLCEVHILREFAKKALPTGVWSEFVEDVEDLVDVRRGVKNQFRVLERIKWAYTKWIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEU5</accession>
    <name>A0A2T6ZEU5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1002092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000329">
        <property type="protein sequence ID" value="PUU73986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEU5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6384" checksum="4901B4011E0DE908" modified="2018-07-18" version="1" fragment="single">YQTESFKDYSLKYSECYDDSHTAAGFFSLGLATNGRLYMPSMSPLGIHYEWYCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF79</accession>
    <name>A0A2T6ZF79_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF79"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF79"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="448" mass="48456" checksum="9058DA5E5F0D1F6A" modified="2018-07-18" version="1">MSYYESQTSWQNQPNRSNWDQRAAGSTPVQAHFPRSHASDPSDLTVRYTASMKPEDPSAFGSQLDEVDRAVDNLVKSGKMFAPQRRDSLPVMGPRGFPVEHDARMVAPMPSRHYSVQEFDVMRSQSAANLQNFYATQRFQRPTEAEQMMQAKRRLAAQRERDLRNYHQEQQYNRSMSSKSPNFARDLAYKGPLALLAEVSGYGKDRVMSPGAMSEDERRELIARQHRALYTSGHSEGSHSEDGVPLEEGNPSRGTNPNSNGPSAPGSNAGGTRGPSPMSSAFDPFGHQNGKIDSNAAQTSGDQNQTGNAISPPIRSRTNSASSPSSKSASFSLFDNAQAQSSRTSASSPGDSPPRSQRVSTTPVTSSGVAPIGTRPNAQNQSGAANNGKRASPPLNSPRYGLQQENDPFNKERSSPAPSNNSAPNGQGDGLDWSKVWGPGSKGLSVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFA4</accession>
    <name>A0A2T6ZFA4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1159781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000319">
        <property type="protein sequence ID" value="PUU74177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFA4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFA4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="374" mass="43386" checksum="7FAD5F3A59AAD5A1" modified="2018-07-18" version="1">MRVSHPANSTASNLSLEQSYLKAAMVGKGEKSEKRGGPENLGTRVVKKESGNSGKLLLVDRKYRVIGGEVALVGKEVDWKVYKGLKKVVGSWENDKVRLEDKMILVNSEWGMSGKGNWESWQDEMEGVEGSEDNSMVAVEEAIRELRKEEGDKRLIKIEKIEEKREEEVVEEISNSEDECYKKGKLDKGKEVEKVEMVSSGIEELSMVEKLKLEKKIKEKQEREERKKREKEEILNRKEWKDYDETVEDARYILGIRKEEGRYFMLDREIKKVLELGLERGLGQGRGLKEEKEEVLVRSEVVVENRLKEKEELKKEVVVEGGRSYSEVLGGSKEKDRESEKLEEKKEKEMIRWLEDSLERERRRGKVVEVVMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFH4</accession>
    <name>A0A2T6ZFH4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1068430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000320">
        <property type="protein sequence ID" value="PUU74164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFH4"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="338" mass="36107" checksum="E13CD4056057954F" modified="2018-07-18" version="1">MTVDHPLSKHSGVVKIVEVGARDGLQNEKGVVPTSTKIELLEKLSSAGLTHIEAAFGADKLTRKSPKWVPQMADTPEIMKHLRSDPPAAPAGVTYSYLTPNMKGLTDFITHSTSNTGVSVSEHASEIAIFGSASEAFSQKNINCSIAESLERFRPVVQRALDNGVRVRGYVSMVIACPYDGPTSPMKVAEVVEGLLDLGCYEVSLGDTNGVGTPGTIGTLVNYLIRDRGIPAEKLAAHFHDTYGQAIVNCLVALEAGIRTFDSSVAGLGGCPYSKGATGNVATEDLVYFLEGTGVRTNVDMEKIVEIGDWISKKLGRKNESKVGTALMARRRNDGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFX2</accession>
    <name>A0A2T6ZFX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_454101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000303">
        <property type="protein sequence ID" value="PUU74383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFX2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="18335" checksum="6AD0E24DCE909573" modified="2018-07-18" version="1">MATTPPAEAGASITSSTSQIATLPTPGNMQYYLTEGLEGVERLQYRGAKSLNKTIDKLITEFQPGGGAPYVVFSPVTQGQLVDIDYIRQRCFKGLRFMYLKDESTLIIKVIVDLTQELAHKQFVRRFERKMFEMGIDMELVPLGAARFLGLLFTISKAVGQPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGE9</accession>
    <name>A0A2T6ZGE9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1092480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000291">
        <property type="protein sequence ID" value="PUU74568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGE9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGE9"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="477" mass="49470" checksum="FBA6AC48E08970B9" modified="2018-07-18" version="1">MPMIYKRFTEKSAEEWRQIYKSLQLLEFLVKNGSEQVIDDARSHLSTIKMLRQFHFIDMAGKDQGINVRNRAKELADLLSDVEKIRTERKKARSNKNKYGGVEGGAGQFGGFSGGMNTSGGDNGFGRRYGGFGSDSMEYGGYSGGVYGDGGGFGGSSGFHDDGSGSSRAASRSQRYQEYDEYDDGGATTSKRTAPPRRQAEPAKPVPKKEPEVDLFSFGDEPTSTKPAGKQNTKPVSNPLDDDFGTLQSGGADDDDFDDFQSADPAPAAPKQPLSFTPLPALTANAAPTNLIQPKPLSAPQAAGLNDLVGIASISPAQSVQSMASPPAMTPATTGGGLGGVGMGAGLGNMGAMGGLGGMTPMKPTNASYQPTQPNYFTSVPTSINSTTPLSPASTGSSTQAKKPAGDAFGSLWSTAAKDFKKPATPSNTTTPSLQAMAKEKASAGIWGAPAQTSHPGSSVTANSGKTSGSALDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGV1</accession>
    <name>A0A2T6ZGV1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1132705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000277">
        <property type="protein sequence ID" value="PUU74723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGV1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGV1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="237" mass="28531" checksum="31970C4F9CBCA251" modified="2018-07-18" version="1">MEVEMGVIGNSIDKDMMMRKEVDWVKIEAELKIWGGNNVMEKKGRWNREELDRVVELLEDGLGERMEECRDRRKWKGGRKKWWNEELEEERKRVRGLEKDWERRGGEEKRKIMKEGRKEYRRMIEKRKGDYWQGFLEELSLLKSFKFVKTDRDFITDVQSIRDEEGILVDKDEEKGRAIIRGLGKREEIEQGREGFYERVELEDELLKDWIWKQNDKKAVGVNGIGGKVVKIMWNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH65</accession>
    <name>A0A2T6ZH65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1156768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000273">
        <property type="protein sequence ID" value="PUU74796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH65"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH65"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="23958" checksum="A7F34282B17BA5E7" modified="2018-07-18" version="1">MVEIVFIFDNGYTLSSENGATVRRDDHLLQKGKYFINTAGSLRVNNEPWLFRTISEGDQAPPEEFRDAVRERDFGCVMTGQPALDAAYGTWRGYTATPIFPLSHEQQWVTHGYDSSITIPGARGSITSVQNGMLLRRDISILFECYDLSINPDDGYKIVSFRGNHGRIAGTQLDKAVLGNPERPVDQVLRWHFRQAVLANVRGEGEPCFDPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH84</accession>
    <name>A0A2T6ZH84_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1103254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000269">
        <property type="protein sequence ID" value="PUU74842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH84"/>
    <dbReference type="OrthoDB" id="5385394at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="349" mass="36735" checksum="7A506CD60429BBF0" modified="2018-07-18" version="1">MDNLREILVSEITGLKSLLRLNADGVGDDDDLVAQLTRTRISLEKFSTELLGSTRSTDVITPDTLPSSVASSPTRSGSSLSSNRSSTTTAASLDGCTPSGGANGGLEEDDAFLRLSSLLAGLQAQAEAAVSSGVSTSAPTTPLVRTFVDSDSNSSADEDAAISPGISGSSGKVRQKCELTRTLSLPHPFLAPAPRKLRKAATLGVSLREECASDANGGNDRGNPTVNITSAPDSPPWNGAGGDTGFRPTPPPSLRYRGKSGNRHRPTLSDVFDVPSPTPTTPDRKNSLLPEGLEIEGLLTEFLEAREKVEMGFQWVWVYLLSGGIVWALVGWLLSWGCMECAVSCEMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHX5</accession>
    <name>A0A2T6ZHX5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_371999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000251">
        <property type="protein sequence ID" value="PUU75098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHX5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="20690" checksum="BF8C196B05729FE5" modified="2018-07-18" version="1">MTRALRLMMETFPWFPRGAVSVVCAYPSHITRCDMSPWCCAEYRTGIYPPCPVAPYQMRSDHLVTNHIRPLPLTPNLPVIVGISGRGGELRKRESEKRKVKIKLTDMVLVCAQVRVLVGRSRSRTLYGRHLIRPSHFSGAAGIFLLPYLDEFTSFPAKCLLANQLAVPSSCRAAAKNCTVLVLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIK9</accession>
    <name>A0A2T6ZIK9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1067516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000237">
        <property type="protein sequence ID" value="PUU75328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIK9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="286" mass="32020" checksum="51288CEF335CF719" modified="2018-07-18" version="1">MARLNDGSSGSSSGVRKGRRLTDYLVEADTGDKKEGQQGTQEGRPWHESSVTRGLGAVSEEGEGSRDTPVYDGETFSLVREEGVERTAEYKRYRDWVIEQGVASYDGQTRRFIEAFEDEAFEAVESYEEQLAKKDNGISRLEDTLAEYLSAPAVLELTEKVKSLEERLKTTETSNMQLIRLLSTRGNADDVDTSLPPGKALKFSMSDAGRRILPIFSGEHTLSGVTNFLCELQRHLELRSQEIGWIDEDGRARHDGWGTYAVMQLKDAAATWGRHMFPIEKVTLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIU0</accession>
    <name>A0A2T6ZIU0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1090457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000234">
        <property type="protein sequence ID" value="PUU75399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIU0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="14518" checksum="5E8A581188E865E4" modified="2018-07-18" version="1">MNKWYTMSSILGRRVLLRWVMLKHTLRFICERKGNLSCSLPNCLVGSGCPLDTGNLFYLDIILISYLKRQTRRNKVDLSVFHSEFGLGAQCTRVSVILASIGTILGYTLLQCEESVCVCTFVLFFRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIV9</accession>
    <name>A0A2T6ZIV9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_352182</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIV9"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16039">
        <property type="entry name" value="PHD_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="302"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU75427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="602" mass="66792" checksum="3966C381AAC155CE" modified="2018-07-18" version="1">MSSLQDLLNPASSGPSSPVHARNATPPPSQLSQTNTQEAANTLTYFANIREHRQLSPQSNTEAAPHESSDTDTVESSSPVPPVSPRRIPAGSPLQNVTTTTTTNGYGHSSPNDRDAIGEQDEDHEMDMESGVGVGGSRGLRAESDRASPAHMEILRSSPPATSASPPSTTAPTPADTTTVDTPTAGTPIATTMPPKSKKSKAVKASAPRKKGIAKLQKKKRKAAADGDDDLEDETTTKKRQIAKKVGKKRESEAPSGYNTETDDQGPATRATSAKRDTTPPRPPSPAIPPSPLDRHNSAGLELYCICREPDSGKWMIACDGKCDDWYHGECVKVAEQDGELIDKYYCPRCTYKGYGRTTWKRKCRLTTCRRPADVAKRPPSKYCSDAHGVEFFELQLDSDRTRYTHSEIKSLTSAATNPAGFRRLGDRMPTPPLSDENWKDYPEEIERLEKIAQEKKALKNRAEANEDRALYIDWAKDRAKRVHEEMKADPDVKHTGKEICGFDERLALDEGEWEIWRASAEGNAVFDNRRIDGRDVCVRKKCERHANWRSIFADESQLQGRLVSERLVQLKHEERKIKDRQKKRSIRDSREGVVETGPWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ40</accession>
    <name>A0A2T6ZJ40_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_352930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ40"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ40"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU75444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="381" mass="41560" checksum="2DB5E8F0DAB3C8D9" modified="2018-07-18" version="1">MTTLAMARRKSPPRKNAIDPIVAIADTVAHKAEDSKDHGSSIFQLIICVGGIYASFLTWALLQERITTTPYGADKKIFRSPLVLNTVQSLFASLTGYAYFSYSSSPGQPSRVFPNVSISLRLLLVALTQSLASPFGYASLQHIDYITYILAKSCKLLPVMFLHITIFRRRYPLYKYGVVFLVTAGVAVFTLYPAHPKKLKKSASSNGEKNMVYGMLLLGVNLLFDGLTNTIQDDIFSRTPKGIVSGPQMMTALNTISSVLTIGYLLLNPWSTELNDALAFVKEHPKVGMDIMGFAVCGGLGQVFIFHTLSKFGSLVLVTVTVTRKMLSMIFSVVAFGHSLSSMQWLGVGLVFGGIGAEAEMKRQSEAAKKAAKQNGCAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ59</accession>
    <name>A0A2T6ZJ59_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_994223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ59"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ59"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="41"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="312" mass="34360" checksum="9767C845C691F980" modified="2018-07-18" version="1" fragment="single">MKLSLGRRRGSELAAIGRGKKDTLKGMHLEDFVRLGGVTPFVLPPELAPGDILIPTCMHAAAAFILNYGLKTPGLFKVPGNPTTIYALYDYYQKQFEEKNEPVVQTISLAKLPSHIRYNVHDVTHLLKKLLYCIPGGLLGSPDVFQALYNIHSFISPDPSLGDHISSKVKPRMIALALASINLHSRISLICAVFGLLRAVSLASDFEMEPRLRDPHETLTAMKEDALSIIFGPLLLGDKSDQILVPENEDRGGLLHPKPVPTTNATPKLSKYTGRHGSTNTKMQTGQAKRAALVCEMLISSWEDICYQLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ89</accession>
    <name>A0A2T6ZJ89_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1131176</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ89"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ89"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="474"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="949"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU75516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125289" checksum="61FD172BC373836A" modified="2018-07-18" version="1">MESSINPSAKKRSFDSPPSELSPPLEDSLLLPTQNMEKPSHIDSDGGLDSRFDQEFKSIVGGDLSIDALRQLEEVSGGDIQRAINMYFDGSWKTMAPKKRKIFHDMSVSVADTGSSKSPKNIPSKIFLGQFGADGWATRSGSKLLSFGDVVGIERQRMRLGDTVPSAGGKSKGKALVADSSQQGGAIGGKSTPLRQRKTQDIVVRFTNSRGEEIGRLAQDTASFVSTLIDQGIAYFEGVCIHAAEKIRTNDTIDLQLSCYLLKESFENSSFRPADTNRVADIFAAKETQDERTLRLRQVALVKLFQKMNLEPKSTNLVTQKHKAAGILQAAEIAEQHEITNISTANKARKTITSDAADESGDEENQSVEEGKELEEDQLNALYQKAQSFNSDTPEAEPADTFAMSLRRYQKQALHWFLSKEKSTNNRVNESIHPLWEEYQWPNTEEDHKKVIRDLGQDSFYVNPYSGELSLKFPKQEQNCLGGILADEMGLGKTIEMLSLIHTHRPEPPSPSIHPTSGFGRLQRQSEDVVPAPFTTLVVAPMSLLAQWESEAEAASKPGTLKTLLYYDSQKKQNLQSLCNASNAANAPNLIITSYGVVLSEFGQVVASGGKRGAHGGLFSVRFFRVILDEAHHIKNRTSKSAKACYELSSDHRWVLTGTPIVNRLEDLFSLVRFLRVEPWSNFSFWKTFITVPFEEKDFIRALDVVQTVLEPLVLRRTKEMRTLDGEPLVPLPKKTTEIVYIKLSKAELDVYRHIEARARSDLARSIEMGTVLKSYTNIFAHVLRLRQACCHPILIRKKEIVDDEMVAEAEYDAAKGFSDDMDLNALIDRYSAEESSASPNLYGANALKEIRDNVENECPMCLSDPMPDQTVTGCLHAACKGCWAHLIETAKTKQELPRCVKCREPINERDLFEVIRSDSPAEEGSQPGSSQGQADITLRRINSRSSAKIEMLVEKLSEVGRSYPERKSCVFSQFTTFLDLIEKELQRRRIKFLRFDGSMSQQKRAEVVNTFKMGQGTNVLLLSLRAGGVGLNLTTASQVFMMDPWWSFAVEAQAIDRVHRMGQTSDVMVYRFVVEGTVEERMVHTIQARKKFIASSLGMMTDEEKKRARMEDIKILLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJH8</accession>
    <name>A0A2T6ZJH8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_887715</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="NESQ01000223">
        <property type="protein sequence ID" value="PUU75606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJH8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJH8"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="15">
        <location>
            <begin position="107"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU75606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="22489" checksum="8DF1E0EB5AD51A0B" modified="2018-07-18" version="1" fragment="single">QVFIAQKMMIAKCNLAGKPLICATQMLESMTYNPRPTRAEVSDIGNAVLEKGADCVMLSGETAKGNYPAESVTMMRETCLLAETAISYAPLFNELRGLTKTLTETSETCAIAAVSASVEQEASAIIVLSTRVGSTARLVSKYRPSCPVLMVTRNANAARYSHLYRGVCPFVYPKPKPNFDQVIWQEDVDERLRWGVSEAVILQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJT9</accession>
    <name>A0A2T6ZJT9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1089630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJT9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJT9"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="184"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="436" mass="50373" checksum="D8D28465461610A7" modified="2018-07-18" version="1">MDFDVAYSLENAQQFWDELDDIVSAHCETQTFIDQALKSYLAFTSSFTEYLVSEYDWAKCAYKLLDSPLFTKHRHYVRRRMIGRLRKEILTPRLHLVALILLYDGRGTQKTFEMMLEEGLFIRLMDLVQKTRDEDRMLWRSLIELLYEMSRIQRLRREDLEAIDDEFISYLFGLVEEDPEDPNDPYHYPVIRILLVLNEQYMVSAHAPRSNPADPPGAPTNKVIKILCFHGSTYKTFGENIILLLNRESETCLQLLILKLLFLLFTTSATYEYFYTNDLRVLVDVMIRNLLDLPDESEPLRHTYLRVLYPLLEHTQLRRPPHYKRDEVLKLLECLSGVRSNHFQPVDQTTMRLVSRCSNVPWLKSTPTENVQPENPAHRALGMSLAHHGQSSVSLMEVASKSEKPGVITPSRKLGTGGADINDNSNGNGVEIAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJX5</accession>
    <name>A0A2T6ZJX5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_312401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJX5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="9627" checksum="37B2B4E40BC45167" modified="2018-07-18" version="1">MRISSFFFFFLSIFSPLCRRLLYIPFCLWSCFYFMSLFPCITFISSFILEHLLILSGRIDRLVRLVLRMKGEVRAVSEEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKM6</accession>
    <name>A0A2T6ZKM6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_992259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU76006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKM6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKM6"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="195" mass="22168" checksum="0CF183D98A582D9A" modified="2018-07-18" version="1">MSINKIAHNSPSHANPSELETSIAQALYDLEQSVSDLRSALRPLQFSSAKELEVGSGKKAIVVFVPVPLLDGFHKVQQRLTRELEKKFSDRHVLFVAQRRILPLPSRRSRVTQKRPRSRTLTAVHDAILHDLVFPTEIVGKRIRTKEDGHKIIKVFLDAKERAGVDYKVDTFGEVYRKLTGKNVIFEFPVVGENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKU6</accession>
    <name>A0A2T6ZKU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBF/Mak21 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1089007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKU6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKU6"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="562"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="985" mass="109900" checksum="0C92BF29BA983EF9" modified="2018-07-18" version="1">MAKKQSSKSKAETKDGLPRKPGKKGGIDKERLLKEIIELGGTQEDLDLVDGIDSDEDGDEIVFAESGKTGRGLQKELRGFLKEIGLEAGKFSTVEDGCEDEDEEWVDDDSGADFANVQALATPNQDWLGTHAETEDENEGGGMGGAEELSSLVSTIKPLKTKPDLKLKGSKLKVAPRPDWHAYKPPPLAPPEVAPSAVTIKSLHDHAKSLLQTENAVYSATHLTKSSDRQFLSTIMTSGTLSDKISALTLICQESPLHTMKSLETLLGLARKKSRSQAVSSMAAIKDLFGPGSVLPEDRKLRFFSKQPEIGARETAAEHLIIWAYEDWLKNFYFEVLTTLEGLCTDPLVFPRINATGFIHSLLSSKPEQEANLLRLLVNKLGDTDKKVASKVSYLLLQLQTTHPAMKTIIISAIESEVLFRPGNGLNAKYYAIITLNQTILSTRDNHEAANKLLGVYFATFTSILQGESTATASLGGTKHIKFNNALKPPRKGDKMNRKAKARAEAEEKNKQFQSDLIAKLLSAILTGVNRAFPFSQVDDDVLEKHIDTLFKITHSGNFNTSIQAMMLIFQVSNSKQAVSDRFYRTLYESLLDQRLVNSSKQAMYLNLLFRALKADTQVKRTKAFVKRLVQVAATFHQPPFICGVLYLLNELCDNVPSGRSLLEEPEQLEDDEEEVFKDVPEEGEERAEDTAKESSVKHVEYDGRRRDPLFTNADRTCLWELIPLLRCYHPSAALFATSFLEHKPMPSKPDLGMHTLTHFLDRFVYRNPKATPIQNRGPSIMQPLGGSDTRGVILSTRGVSKAQIPVNSEAFWKRKIEDVDVDEVFFHKYFNQIAPKKPAVQKRAKKAGRDEEDEDDEEASEAEGEIWKAMADSRPDIEEGDVDFDDEDDIAELSDISDDSDEEMQDLAEDEDDAWKSEDEDSKDDEKEAPRNLQKAFEAELEIATGENEEEDAAAEGESRKKKRKLKHLPTFASAEDYAHMLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL10</accession>
    <name>A0A2T6ZL10_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_272497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL10"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL10"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="60" mass="7046" checksum="0C527C9E9124D535" modified="2018-07-18" version="1">MAKKAAKSRTILVRLISMAMTGYFKSLVRPRTHKPLSMIKYDPVVKRRVLFLEQKRGKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL41</accession>
    <name>A0A2T6ZL41_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mss4-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1052466</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000197">
        <property type="protein sequence ID" value="PUU76205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL41"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL41"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="13296" checksum="0944604A22C9DCC6" modified="2018-07-18" version="1">MTSTEKTYEGSCHCKSVKLSVTLPAPIEEQKVINCNCSLCVDRALLIFFAAGDKVTIEGEEHLNPYSFNKKVIHYHFCKNCGSILFGHDKDKTQYGINARCISGVDLDKLQLVKHDGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLL1</accession>
    <name>A0A2T6ZLL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_257406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLL1"/>
    <dbReference type="OrthoDB" id="5381348at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="290" mass="32349" checksum="D979E45E2DB21F4C" modified="2018-07-18" version="1">MSASKSLPNRRSRPVSGVYIPLSPRFSSARSSVHYANELLEDMLEAGERNQGAAAARTSGKKALSRPGPPPKRGLPPPPLYPHDPLHEQPRKSAEETPNHRHSLACPIGVSYLQLESELSRSASEREVIWRKRKSREEWVKARKERDIQQARMMREKRLEGKLCDNGERNSESWREKTITPPSTPPLPQNSRPATLTPTPTPSPTSTTPIPTPPGNSLKEGTCSTISALSASAKEMELEERVLALERKNKMLEQTIMAVIRTGIGPSRRGSFLLQAKSLEEFLRELNLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLT8</accession>
    <name>A0A2T6ZLT8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1194721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000188">
        <property type="protein sequence ID" value="PUU76457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLT8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLT8"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="66"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="744" mass="82757" checksum="BBF6A49885EA02CF" modified="2018-07-18" version="1">MSNFRTKLPKWTALSLGGNNGYRGQEGGVRAGRESSTESVTLDSEITREQKRSFSSAWKPVWYTSWHTGVLACATSVVVVLIINVGLTIYAATNPKYKMEGGIGTLYSGSCDKSRTIGLWLHLLINALSTVLLSGSNYTQQCLAAPTRREIDTAHSRIRWMDIGVPSIRNLFNIKAERTFLWIAIGITSIPLHLLYNSAVHTLLTANDFEIYIVTKDHFEPGAYTNTSSHVFMPFGIDHAADRWTNADVQLFYSMLEGSNTGTERYEDLEPSECAKRYNTDFLSTNRNLFLITSHTSNATDNDTLLDYVYLYPGDVSPSRWMCRDGPVGVSKIGDLCNTNELVSNVTRGLPWQMDLGRVGLISSVGVIEISGCKSERTEENCKVQFSLGIMIAVICCNLVKACAMVMTVVRSREPTLVTLGDAIDSFLRTPDQTTIGICYADRRFIEKEWGWRMRTGPREWNQKGAQRWWTSASKRRWITPMFFCSIAIVITGALLGMGIGQERTSVKTDIKSLWARGFGKLSSFSLVTIPFQNKTQAILLANLPQTILSFLYLTYNSLFTCMLLGHEWSLFSHHYRTLRVTSPRPGQRSTYWLQIPYTYAIPLMTLSGLLHWLTSQSIFLARVDIWDPFGTAVTRRISTVGYSCIAIIFALPLGVLALVTAIGMGYRPFAAEITAVGSCSAAISAACHASEADLEGIVGKTVRWGDVEIVPNLGVRHLAFSSEEGVRKPEFGEVYAGTRREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLW1</accession>
    <name>A0A2T6ZLW1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1088186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLW1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLW1"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="419" mass="45689" checksum="797D5676129D5A4A" modified="2018-07-18" version="1">MSSSSLSQRPTLIRLTRYDTPDADQFVLLHATPTSAVHPLNLKLYATEGERAFATDITQSKIYELRAGSYTGTSEDLEKIFLALLLKQDTGIERGVELAAAVDAKGVTLTVRQDIGGIKQRIAALQIPEEEVEIPIFDWAVEACGNLSSGSTQLGDLQSKVKSQEKEIEALTKQLKDLAVFKKEHEEMLLVKFSELLNSKKAKIRELSRELEIRGGDTVSSKAESPIVENESEVAEPAPIRGRGTRGRARGRAKAAAPRKRKPIAPPTDSESDAFVKIETDNKGKPSPDDETEDSEEAGPSRGYLWQEARSDRSVTEDEDELPPVRRPIAFTIKKPDPESEGTPDEDVEMDEPPQAQPAKTGGRARGGNGKGKAPASLPISRGKSRATRSKPKEPSPSLPSSAASYNYNEMGDSEDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMW6</accession>
    <name>A0A2T6ZMW6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_989308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMW6"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="97"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU76754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="263" mass="29469" checksum="4322E3B754043786" modified="2018-07-18" version="1">MVGALAALVVRVVLIHLVLMNGTNNLSDPRNLSDGERRRREFGSKMVLITRTCYVLFIWFMKFGIVSFYERIVVKLESRRVWLKYLIFGRQVYPDPGEACSSSQAQLYTTGVCNIFTDLILIIYPLPIIFNTGLRLRRKLQIGGLFSLGFFVIIVTIFRLTFVVRNNVLLKWRALFGHIEMLVACFVANAPALYRTIGVRVHITPGTRYSGEVPLGRYCFAANRRGRAGGRGLSATSTEEPEEGEGPVGGGLVCMLAHDRCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN89</accession>
    <name>A0A2T6ZN89_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_205204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN89"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN89"/>
    <dbReference type="OrthoDB" id="5448793at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="310" mass="36488" checksum="21DC0F4B28D46FEB" modified="2018-07-18" version="1">MRTRIMGRGNLSLKHGWEMITLVNRFVSETGAGDFPGKFCENIYNILEAMRRGKNSLNFYSASIISLYEELTLSLIFLVRPYEFLIPDSWHRLYFKRWERKYRSSSVLERFLYQQCLAKVCLSFCEMIINIEGRPTKEFSLARRSITIIVVCLINLGTFFPRQGYAELWRKSQEVFRCARLDARGILGLQGDELIGRLTKVFLEYKGRDSIRLVWGRQGSPDSFAGIPLKRNSISVVASRPTEERKRHLWKPSGDQHTRQLSAAHILTAFWKLRFLEKMKERRRYFAPRYKYAKDCCLLVDMGGDRNWMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNQ1</accession>
    <name>A0A2T6ZNQ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1050761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000162">
        <property type="protein sequence ID" value="PUU77129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNQ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNQ1"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="14751" checksum="1545870F717E34E6" modified="2018-07-18" version="1">MAKRGRGGAAGNKLKMTLGLPVGAVMNCCDNSGARNLYIISVKGIGARLNRLPAAGVGDMVMATVKKGKPELRKKVMPAVVVRQSKPWRRADGVYLYFEDNAGVIVNPKGEMKGSAITGPVGKEAADLWPRIASNSGVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNX6</accession>
    <name>A0A2T6ZNX6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1128582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNX6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="29518" checksum="174A96B54F8901BF" modified="2018-07-18" version="1">MPKHIVKSRLEELEETVKDLSREVQRTTSENLGLHNRIEKTDYYLSGLLISYKSMAKLMTALEGRCIALEERCSALTQELSLQSLHLNAPGIIGEEEEKSLNNFIGELLQIQLGASHIANPPEPVQSEFTATMEVHEALQLGPTGRKRKVQEMAKSGPGTATPVSSSYGPIMFRNTFSDEVPTKRPTRDPARRAGRPKVGVQQLMTPPEEPAQEHQVHEEDILVTEEQHTEAVSILFENSSETFEFRSDDYDYDLFRPGNWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP06</accession>
    <name>A0A2T6ZP06_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1128595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP06"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP06"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="193" mass="20549" checksum="A2033C60DE11E6F6" modified="2018-07-18" version="1">MIAQGLLALDVSRLFPPKLDLSCKPSFSGVEETFGDQYLSREAGCSSIRGPQKNALAATVKHFAGFRTPERVLNTAMGVYGHKREVRRTYLLTSKRSTFDADAGGVMSMTVSLQGQIIVYLPGPVASTNSAATASASAVTNAVTIPHHDIETGDGACNHRAIPRKRSSGTAVSRMLRSKFGIGLFENPLPTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP62</accession>
    <name>A0A2T6ZP62_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1101941</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP62"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP62"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="11"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="266" mass="28546" checksum="2FA68D6169937700" modified="2018-07-18" version="1">MIRDTRWPSLPLIVLRGVQLLFSIIVLGLSAYTISVINYWWACMALVSAIFSIIYIGINFFLLFSNLLLPLAITITDAFLAVFWLISMAGAADSGYLAVKDCEFALLVDIFSYYVFTSTVCQVIKAAFALSFLLMLLFIGSLVLAAVVLSKNQKDLRGAKYNSGMDPDGNPLPGNAGAASVAMGNVPTPAPQYYQDPPKNEYYQQPPTPQPYQPTTSPVYYNAAATTQPISPPATPAPYSQGVGHPGAGAGAPPPPPVNTAEMPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPH5</accession>
    <name>A0A2T6ZPH5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1086442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPH5"/>
    <dbReference type="OrthoDB" id="5364720at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="335" mass="37337" checksum="EA5C9E1EEEB3208A" modified="2018-07-18" version="1">MASLQQPIGPALPEKMSQPEKRPRGRPPTFTEEERLQRKRDLARIRQARKRERDRVRRWSTGQDNEEMGSQGISSPPDNSADGTDTNSLSQKTDQSAWGLEKAVGFQVQVRRTRDNSPSDQEYPAPGDEGIISREHNLPARPAGQPSPQPPALPLPLIPSDSTVCDEPESYDRGHESLATWHKIHSISKALEASQGSRVMRNQLASLLYTNELVSLIQSWEEAGFMARGRASPPPSSIAQQQTGMPTPLPSTSSHESVFPGGSNGRPEESEDELMERILDNLSGRMQALKRRKGLKSEVDELRKALADKEAKLKECNAILEAERAVWHNFQNMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ20</accession>
    <name>A0A2T6ZQ20_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1108812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000149">
        <property type="protein sequence ID" value="PUU77567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ20"/>
    <dbReference type="OrthoDB" id="5486507at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="19438" checksum="B17B328A4581532E" modified="2018-07-18" version="1">MSTISRFPIKNLLSQFNKRDQTDNQGGNSNDDRSPAVIAGLVIAALTLLLAAMSYRRPRFGRSQAGSSLLPSHFVNTRNPLHQVPRNVLPDLSATIPPTEFPRAGQVFIYNDYSNAQFAGAHLSTFSYRNDTISSGDTKHLGWFGNLSINADMSSVFPTALGSESVGRPSLGRIVGPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQL8</accession>
    <name>A0A2T6ZQL8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1193781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000141">
        <property type="protein sequence ID" value="PUU77767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQL8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQL8"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="239" mass="26866" checksum="B8BE0E0F48A76D72" modified="2018-07-18" version="1">MDCYYCGAYIDLPDPPPPPPPPPPPPVKPPPEHSPEYQDFLSGGTITLYVGPKRKKMEMHKKLLASISPELDKHINNDMKEGIEGIINLPDEGEEALTLFTQWAYTGDYTHKSITPKSPVDLKDPWPSLHKHLQLCAFADKFNVSILQRLAESKFYTEIKPVELKSERDAAGLIMVIGYAYDNLPSSHPIPKVLARYASWKLGLLRETTEFNELILTQPAFLKELLPHLDGLSARPQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR72</accession>
    <name>A0A2T6ZR72_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1108550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR72"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR72"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="3">
        <location>
            <begin position="53"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="651" mass="72509" checksum="68EEDCE087BEF9B7" modified="2018-07-18" version="1">MATGLLGGNSYDRGGGGGSESSPRESSTLDSEFTQEQSKSFFPAWKPVWYTGWHTGVLACATSTVVVLFINVGLATYAATYPENETGRGVRTLYSGSCGRSKTIGLWLHLGINALSTLLLSGSNYTQQYLAAPTRSEIDAAHGTRRWLDIGVPSVRNLFWIKPERTLLWIAIGLTSIPLHLLYNSAVFTSLGANSFVVTVVTSDHFEPGAYSNLTAAIPYREEDRTFRSALEDYNASTSTYKDLNPSECIKLYNTDYVTSYGNSFLITQHSSNTTHNNTLLDMIYVAGYETLSNIWPCSYHLMHGFHVHRVSEVACNPSKLMSNVTSGLPWLMKLTTGEEVEIGGCKSERTAEQCKVQFSLEIMIVVICCNFVKACCMVIAVIRSREPTLVTLGDAVDSFLRTPDPTTMGICFADRQFIEREWRRGRRTEPRQWKQQEVKRWWTSVTILLVNLPQTILSFLYLTYNSLFTCMLMGHEWSLFGQSHRTLRVTSPRPGQRSTYWLQMPYTYAIPLMALSGLLHWMTSQSLFLVLIEMSQPSEAIQRVTSLGYSCIAVIFVLTLGILAFVTAAWVGYKQLSAEITTVGNCSAAISAACHTSEVHPEEIVGKKIRWGDVGSEPYLGIRHLTFSSEEGVRKPVFGETYLGNGREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSM1</accession>
    <name>A0A2T6ZSM1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">agmatinase</fullName>
            <ecNumber evidence="4">3.5.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_983224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>agmatine + H2O = urea + putrescine</text>
            <dbReference type="Rhea" id="RHEA:13929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="3.5.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.11" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSM1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSM1"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019627">
        <property type="term" value="P:urea metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000006">
        <property type="entry name" value="Agmatinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015749386" description="agmatinase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00050304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="395" mass="42689" checksum="62A65DA3F7980B36" modified="2018-07-18" version="1">MFTKTLLLTALVGLGGDAVWGHEHSGSLQEHLSAQGPHKERLWYNVLPGDGGTQADSVFSGISTFGRIPYFPCLASDEEKFDIAFLGAPFDTGTSYRPGARFGPSGIRQGSRRLNLYGGYNTLLSVNPFNSWARVLDCGDIPVTSYDNAYAIKQIEQGHYSLLSRTPAYEADEGRKGPAKDGKVLPRIITLGGDHTIVLPILRSVKRAYGPVSVIHFDSHLDTWVPKVFGGAPTEQASVNHGTYFWHAYKEGLLKNNTNIHAGIRTTLSGPSDYENDAVVGFDLIEAHEIDEIGVGGIVKKIRERVGDGLVYLSIDIDSLDPAFAPATGTPETGGWSTRELRAIIRGLDGLQLVGADIVEVAPAYDTNAELTTMAAADILFEVMSVMVKTPLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT00</accession>
    <name>A0A2T6ZT00_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT00"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="18315" checksum="87903A86B5252B1C" modified="2018-07-18" version="1">MITIAFSTIYLNSQTPINLLPPERRDEYGRARSSDLHIWLVVENGGRHEGTISGPRVGNTTISDHCLNPFHQTSFGRLSYSLSALSSISRYSRRCLSFLKTYVPHLSTKGQKEHYQIKVLVISNAVPSSYETPCVIAEPPGTSLFPLRLTGEPKARTKADVQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT67</accession>
    <name>A0A2T6ZT67_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000110">
        <property type="protein sequence ID" value="PUU78675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT67"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT67"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF223">
        <property type="entry name" value="CYTOCHROME P450-DIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="540" mass="60536" checksum="0F201FF650C18AE6" modified="2018-07-18" version="1">MLASLFLASALLFMGYACYSLHTLLCKVRPLGIPYFVIPFYPSPLPRVFLLPLMKLIIKVFGLTHHWFFLLTLNWQVHQRYKIYRLLESDIFFTVTPWEVILHVADPDMAVEVLAGKGENGELYPKTEVVSRMMGLFGKNVLTVEGAVWRGHRKVTAPIIGKSLSIVWEEALTQIGQMIQYYDKNEAINTSHRDFRRATLGIIAHAGFSKIMNWVPLTTAIANEKDGEGSYQKCLDILFENFKWTVIAPSWLLEILPFRASREAGGAAKGFRRFINEWFEEKKAKIELDNNTGPRPSSRTDLMESLVRNSGLDKGSTLETPLLSKSEVIGNAFMFILAGHESTGHTIANAIYFLAMYPEYQVKLQNEIDSILGDSDHNQTTYNTHFDTFSSGWIAAIMFETLRLIPAVVVVTRQIGPVPAPSLAQVAEDLSRSPPVLNSGSNLSAWLKTQNTGPSPGKLKPNLQSPNSGLNAGSRNQEGIPWLFREMSVEFDSCGGRKTFDEARRECLAEMDKFATVITLRPSAEMPGIKWVRRKKGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTD2</accession>
    <name>A0A2T6ZTD2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000108">
        <property type="protein sequence ID" value="PUU78741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTD2"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="672" mass="76935" checksum="B143B69BB2C9275C" modified="2018-07-18" version="1">MDWAENGVWPVRTYSDFVVTRGLPLIDYPPERCDAVDVYDEIFHAATNDPRSIVIYADGSKSGTGTGAAWVAYERSIFSYPVLLTTPREWSLEHFAEIAMGWSPGHAGIAGNEIADVAAKKALTGMCRITTAVDFSLQNNCLIREIREEEWLGCVMNRADDCLGGGKSEKSERLVAQFITCYGLGNWIQRYGRVRILLWVTDSIRDGYLPRSIAARARPAATAEAIIDITEVATSDEIRKGRGFPKLPVINQDNIRVEEARRGIKLNVRPKLVEDEIKKLVAEKLALARTRDRRTKHLYELQKELEKTTAKVRKIFEAIRDGKKPKPPRSLPIEEQVRVRNRYDEIWRTFGHKTEAELAAEKLQKIEDRRRRGATFPKTPSRPRMLPQSSRPPTIEEIEAIEDKILKNPGLWIKGMEHPLWYYHGDKKELREFVIKMAAEYPVLRVDPNQVIQPEDIYSVMIEAMEEGGDQPQGAATGEESSTPSASVSKEGDKAVARIWEEYEERWSPKSKAEYKENVREDQIYSARKKLLKVYNRPYEPLHVDPKGDFFPHVPMTLLEMVPKVPHPSLSGPTPFYRESNWLTFEWLLRHLFMLRASSVSSALRSLAPGAENILADLPAHQRIPPTRRVRCLEVHDLVNLTMAWTRWPFRDPGSQFENHIERNFSSKIPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTG8</accession>
    <name>A0A2T6ZTG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTG8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="8012" checksum="8470929E9E51EE90" modified="2018-07-18" version="1">MVKFKPAHLPIPLQFVSLSNVPVDITNNVGDRPSSPFWLGTPPENRAATQEKWSDSETDNNDNGDETGEVDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUC1</accession>
    <name>A0A2T6ZUC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_18842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUC1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="13256" checksum="D62B6184B65CE03A" modified="2018-07-18" version="1">MSITIFIFIFLLLFHLFLSLLWNSISSLLLAAPQQRQQNGRRHRGLQKHKHKQLAFSPPIDWFFPPAAVHFVLLTPRCSLIPFILLFLLPLFSGSYNSNTIQPGWAIQTAGIAPFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUL6</accession>
    <name>A0A2T6ZUL6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane amino acid transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1082328</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUL6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUL6"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="211"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU79181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="618" mass="66581" checksum="9638DBF38C47EE0D" modified="2018-07-18" version="1">MSYPAKNGEAGLSSGSPTPTPGAYFPGHHDISPSSSSPNVDIPPTGLRQRRSSLSLGLDAIRYAGGVNSLDNFARSWTRAAGYLEITPSRQSFVSVDPSRDEEENSSCAIDDENYYEDAEVTQHLAARASLPATGFGSYGSISRYGGTGTGFPGGRLNDTATRHAGDLFVQKQTAGEVVAVDEALDKEREPLLVTTVTTESGSVEHIIVGQSTLPQTVFNSVNVLIGIGLLSLPLGLRYSGWLIGSIFLVFSALITNYTGKLLARCLDKSPNQSLVTYSDIAYIAYGHKSRVCVSILFSLELMAACVALVVLFSDSLNALFPQIDKLQWKIVAGFVLTPLSFLPLRVLSFSSILGILSTFSIIMIVFIDGWLKPTAPGSLREPMATYLFPQSWWTVPLSFGLLMSPWGGHSVFPNIYKDMRHPKKYNRAVDITYIFTFVLDITLAVTGILMFGDGVMDEITSNILEGSGYPAALSMAMVGFVAIIPLTKTPLNARPIVTTLEIFAGVDPRAIALQGELVGMSGLTRGLLKGLIRIGVNTSFVIVAILVPSFDRIVAFLGSALCFSICVILPMMFYLKIYGDEVPKKERRINQILIVVSTIVATVGTVAAFVPKENLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUU9</accession>
    <name>A0A2T6ZUU9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUU9"/>
    <dbReference type="OrthoDB" id="5423638at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15515" checksum="D9ECA8052A21A981" modified="2018-07-18" version="1">MDVVRERERRHGPVYALQKPLPPNPPMEAEDEEEEDEQGRMAEHWQQGPTAVPPVVNKSLRIPQNPSTRPGPAVYPGYSTDTSQILPFDQGNASSENRPPGARVSVQGRVADGSDGKDNESPSSQPLYANSELREVIGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV48</accession>
    <name>A0A2T6ZV48_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1081802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV48"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV48"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="137"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="294" mass="32866" checksum="A0B1FC1578A5A0E0" modified="2018-07-18" version="1">MKPRPPSNLRCIATSTTPSPNPLVPPRMSPLPILSPPTLPSFRDSYFNPTLPCTFPPSHFTSTLPAISQWFIPHPKYPHLQVPNTQFFHKTLANRINALLLMEVSLHSEGKFLQIHAPFAKLLEDISFAGPRDRSITTYLAQCSINEIPELKDTLPTPQYIHAGKGDVYNVNLWMGHAALIATPLHKDPNPNLFVQLAGTKRVRMFDPDTGREMVQEFGGGVKRFRMPDEMMEGKYRRMIDKVVWGEGDAGDGVSGFEATVGPGDGLFIPKGWWHAIRSVGEEGAVASVNWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVB1</accession>
    <name>A0A2T6ZVB1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1125303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVB1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="8515" checksum="437AA1C56B3E47A3" modified="2018-07-18" version="1">MEPLYLYHTGNKVIASSSGARRSRDMEVRGEGAEGRAGGFLYVLWVGGGEMLAIAVSIFEFAIDQVTTHRSAPRRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVD2</accession>
    <name>A0A2T6ZVD2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1081736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVD2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVD2"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015369309" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU79436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="471" mass="50393" checksum="D9DB509818667B7D" modified="2018-07-18" version="1">MKLQSFVLAALLAGSASAVRPLTVSGGNFVNSAGDRFVIVGLAYQPGGASGYDPASGKDPLSDPDICLRDAAVMQRLGINTVRVYNVNPDVNHDMCMSIFNSVGIYVALDVNSPLAGDSINRHDPGSSYNEGYIKRIYSVVDAFKGYPNLLGFFAGNEVVNDVPSASVVPPYIRSIQRDLKNYIAKHASRTIPVGYSAADDPTRRPMWAYLSCGDDADSRSDFYGLNSYQWCGDSTWESSGYQGLVDTFKNTSIPLFFSEFGCNKISPRPFGEIAALYGERMISSWSGGLVYEYSQETSNYGLVQIDSNGDARLLKDFDNLQGQYNNINLNLIKNKSSSTTSANHPKCEDTFILLGHSDTFNTSTTLLPNPATDLLENGSGNTNVGKLVSVTQTKTPHKVFTSTGVQIDGIEIKMLKDDESNTPSGENTSSAAGGSGGSSGNKKKGAAEGLRVSAVLVVGVTVVVGFWGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVG1</accession>
    <name>A0A2T6ZVG1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1081757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVG1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVG1"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="258" mass="27991" checksum="3682A55942871AA5" modified="2018-07-18" version="1">MIIQIKNKEEVTAILGKTPADKLVILNFYAAWAEPCAQMNQLFEAIATELPDAATYLSIDAEDESNASTTEEYDVSAVPYFVFLKGETVLQQVSGADPALLKSAVEKHSGVGTLNLPPKQSTTSSSSAANGTATEGGGEGGGEDGIAEDINERLKKLVSAAPVMLFMKGTPAQPQCGFSRQLVALLREREVRYGFFNILADDEVRQGLKVFSDWPTYPQLYYQGYLIGGLDIVKEEFENDPDFLRPGIAIPTEIPTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVG7</accession>
    <name>A0A2T6ZVG7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVG7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVG7"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015483215" evidence="1">
        <location>
            <begin position="28"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="307" mass="34682" checksum="EEE76F03B14A9C69" modified="2018-07-18" version="1">MCRHWNVFWAGLALCLVFWVTTPLSSSLLTTQPVARDIETSFKTFKRLTPFDDQKVAMSASFFYTSYGVTWLGEKVHSFMTKELIAIPFKPASYREGQDHLKRGNESWTSQTKVYQTELACTPAKIESSGEYTYQFSTDKCTSPVYPFVNSNATRNMMYIGFANGDGIGQWYLTKNDCKDPDLFLAIWAKLRNTYNASDELDLNALYCKPSYHYQTYEVMVDGTDGSILKADPVGERTNFTQEDKIIDIIMFEGNVGAAATVSGVNAKYFPPEAPNTMVRFEDWGLDYPTGQISYVIGLNSMTLKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVR5</accession>
    <name>A0A2T6ZVR5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Anaphase promoting complex subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_826059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVR5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVR5"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="560" mass="64397" checksum="D93B4DD0C0A8CE50" modified="2018-07-18" version="1">MATEVPDPHQLHAALQTAVLKCSERCLYQAAKWAAEALTSMPPLVPQNDTPLPQTYLHPTSSYENEAILQAGELPTYLLSKSYFDVHEYDRSSAVLANCRSSKSRFLHLYAQYIAGEKRRDEESEMILGPLDTAATQNREVQSILSSLEAIFTEKGDDINEDDSWLLYLYGIVLLKQKNEDEARASFIKSVNLYPYNWSAWLELGSTLGNLGDLNNILQSLPNNIMTNIFVLYSNQELYQTSDPVHAQLADLQTIFPTSTFLKTQRALLYYHAREFDEAEAIFDSIVKADPHRLDCLDHYSNILYVMERRPKLGFIAQLASATDKFRPETCCVVGNYYSLKSEHEKAVMYFRRALTLDRGFLSAWTLMGHEYVEMKNTHAAIEAYRRAVDVNRKDYRAWYGLGLSYEVLEMHYYALFYFQRAASLRPYDPQMWQAMGSCFDRMNRPSEAIKAYKRALISPTNTSPDTAVLLQIGLMFEKLNNQKEAARWMEMCLKEEDENSGVTQATSKARMWLARWEFVNQNWTKAAEYANELCQDGQEIEEAKALVRDLRSRMEVGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW12</accession>
    <name>A0A2T6ZW12_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1064086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW12"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="18402" checksum="1B8B08DFCE707A64" modified="2018-07-18" version="1">MADYGNNMYDGGEAEAEFMQSNGFCDTFHVVEEARNGQHLKVFKFTNSAASIFIELLQAQYHLKALFKLLYFNHLLLSKTSPDLESWLKYSHFLQSRHMPPSTLFFVRNKKRLEVKGTPWLPIFPGGAGGNCAGSCIESLKGCDLIFPMGDREFRRLERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW20</accession>
    <name>A0A2T6ZW20_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1064090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW20"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW20"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000504">
        <property type="entry name" value="C2H2 transcription factor swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001649">
        <property type="entry name" value="C2H2 transcription factor Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF144">
        <property type="entry name" value="METALLOTHIONEIN EXPRESSION ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="360"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="671" mass="73305" checksum="41A449FE24713440" modified="2018-07-18" version="1">MLQSPKKKPQRPRRLTSVTENPILEAKQDNKRQLQQQQGRQLQVPASYPTPSRHREGYRGQQHRRHYSVPDLMMVGSASARLSSGHVYPARNIENLEIDVNCGHDQPHLTIDNFNNFCVLQPQRPQTPPNQHTGEFYPATPQTPFECFPAGNQDAAQMIDDLLSSIGSPVSLTPRRQSMVALSSPLRATFPLEECGEPDLHQQNGIPDSLPTPPHTGQLQSVSTFDLAPLPHPNFVSMAAVSMSSESEGESYYSPVSSMSPAFSSVPSTPEMKHATLYKTANTNAMPTVPEHSTPSISSLPALDLPQLAPAPRHVPGTPSPVRVRAPAPHLAQSLGAKSSGITMEEISSFISGPDQDGKWLCLFPECKKRFGRKENIKSHVQTHLGDRQYRCEACKKCFVRQHDLKRHSKIHTGVKPYPCLCGNSFARHDALTRHRQRGMCVGAFEGIVKKVVKRGRPRKKPLPEDSQKSKAEETSDSSAADGSSGSSNPQTPYELPDFGSPLPQTPSPRTPTSGEEEEATPRCRENSSDFLTQPAESPGYSPPTSPSDEYDFESFVSPPSPSSNRNSVGSSSLAESDFVPSYGPLATNTTTATTEQVVGASMKKFGAGPFGSLDEYASSSGAEEFGLFSQDGMDMLGLTALERDPSILNFDDDIYIKPEFMANAENGSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWL0</accession>
    <name>A0A2T6ZWL0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_779621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000079">
        <property type="protein sequence ID" value="PUU79868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWL0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="69" mass="7187" checksum="FD2BF36CDA75498B" modified="2018-07-18" version="1">MTKNLKIERENQGHCSSMISVSGAKGLSGGGVEIDSQKAWWGELPKRDGNLVVARAGGEGGMSGEIKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWW3</accession>
    <name>A0A2T6ZWW3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1100558</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWW3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWW3"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000031">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="913"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="472"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="648"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="783"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU79973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="955" mass="106369" checksum="ED22510FD887BECD" modified="2018-07-18" version="1">MITPSIPRGSSDLPTRRSGGTGSYNTIKVVARFRPQNSTEIREGGEPIVSFPSEDTCELTSKEAAGAFTFDRVFDMSSKQADVFDFSIRSTVDDILNGYNGTVFAYGQTGAGKSYTMMGADIDNESSKGIIPRIVEQIFASILASPGNIEYTVRVSYMEIYMERIRDLLNPANDNLPVHEEKSRGVYVKGLLEIYVSSVQEVYEVMRRGGSARAVAATNMNQESSRSHSIFVVQINQKNVETGSQKAGYLYLVDLAGSEKVGKTGASGQTLEEAKKINKSLSALGMVINALTDGKSTHVPYRDSKLTRILQESLGGNSRTTLIINCSPSSYNDDETLSTLRFGMRAKSIKNKAKINAELSPAELKSLLIKAQNQNLTFAEYIASLEGEVTIWRSGDPVPKEKWVPPIKIELPKVDARTRRADTPSKLAAAEAVQSPSRPESRVEVRSSTPVILEKDEKDEFLRRENELQDQLADRESALAASEKTLADLKEELAFLKEHDTKTGKDNEKLSGEVNELKLQLEKVSFESKEAQITMDGLKEANSELTSELDEVKQHLLDVKMSTKETSALLDEKEKRKAEKMAKMMAGFDLGGEVFSDNERMIREVIHRLDAIQDNSASGQEITSDDIRDLRARLVETQGIIRQAELSLNERSEEQDLAQKRREELETRLLDLEQELEELLERNLSDEDIAEVKARLEQAYFSKQDVEVQMLEDLKKELSKKSDENERLKVSVDELQRRVKAGAATNGTAGALPGGKTVAQQIAEFDVMKKSLMRDLQNRCERVVELEISLDETREQYNNVLRSSNNRAQQKKMAFLERNLEQLTHVQRQLVEQNSTLKKEVAIAERKLNARNERIQSLESLLQESQEKLTAANHRFEAQLTAVKERLEAAKVGTRGIGGSNFNFQGSRIAKPLRGGGGASGDVNGAPVPLSGVQGSAAQQETQHPKRGSWFFDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYI6</accession>
    <name>A0A2T6ZYI6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1106999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYI6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYI6"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="20641" checksum="6013055CBE7BB8C7" modified="2018-07-18" version="1">MTIYSFYIFDRHCECIYVKQWHQRDRTFRPTSSSASTADSPVTLSSDRRSSTSSKLQNEVHPSGRGGRLSVQDDAKLVFGVVFSLRNMVRKLSGPDDSFISYRTGSYKLHYYETATNLKFVLLTDVKMNNLKVVLHQIYVNLYVEFVTKNPLSPIEHPGGEGVAVELFEMGLDSFIRTIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZC7</accession>
    <name>A0A2T6ZZC7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_957994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZC7"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8106" checksum="6068F711B2BE7ED0" modified="2018-07-18" version="1" fragment="single">GREEILMRLLRKNGAELNPVNDKGLTALAGAVWCGYFGTVKMLLGRSGVDLNLGDRVGCSLLSLASEAGCGDVLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZQ4</accession>
    <name>A0A2T6ZZQ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1078152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZQ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZQ4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="56" mass="6134" checksum="7B41FCC849F96CDD" modified="2018-07-18" version="1">MIYLDYVLFMQQLIHEANVNARTGANGVVAGAGKKVGITARDVRKVSQVTLRKFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0U9</accession>
    <name>A0A2T7A0U9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="11" type="ORF">B9Z19DRAFT_1122247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0U9"/>
    <dbReference type="STRING" id="42251.A0A2T7A0U9"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000235">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="33"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU81354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="739" mass="85928" checksum="32FE18CE9D7BB29F" modified="2018-07-18" version="1">MAPHREDEHDDEEIDFSDLRERYEVQLDEGLDTFVVVDGCPKVPADSKPKLIKFLCKRLTEVGRISQDSVFMPLNEETNMTEGYAFVEYDTPDQALLACKQLNGMALDKKHTVSINKLTDIEHFGREGRIKEEYVEPEIEPFVEQEHLRSWLSDINSRDQFIMYRGENVGVFWNKKKDVPEPVVDRAGWTESFVQWSPQGTFLTSVHGQGVQLWGGPSWKRIMRFAHPMVNLVDFSPNEKYLVTWSNKPISIPENPPPNFPLGPDEDGKSFIIWDIKTGNLLRSFTSVEVTGDRDAELFEKSRKKVSWPVFKWSSDDKYVARVVPEQSIQIFETPSMLLLGKKAIKIEGVVDFEWSPSIPTAEKSKKEPEQLLCYWTPEMNNQTARVGLMSIPSKEIIRTRNLVNVSDCKLHWQSEGKYLCVKVDRHTKTKKSMYTSLEFFRVKEKNIPVEIVELKQVVINFAWEPKGDRFVFITVDEAIQGAQVAPKTSVHFYAPEKLKNGVGEFCLVKIVEKKNSNAIYWSPKGRFTLIATVHSQQSFDLEFWDLDFEGEKQKQDKASKNKDLAANLMLMGTSEHYGLTDVEWDPTGRYVATSASMWKHAMENGYHLWDFKGSLLREEHIDKFKQFLWRPRPPTMLSKEEQKQIRKNLREYSKQFDEEDQFEAEVANKEVLEARKRQLDEWRAWRARIEKEVRWERVDLGLPEDPEEALREAAGEEEDKIVEEIIEEVISEHEEEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A288</accession>
    <name>A0A2T7A288_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_544669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A288"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="21467" checksum="6F60D7C7F6291056" modified="2018-07-18" version="1">MAPLPAADPSPAPSPAPSLQSTIYSIYKKISAFLKKNPELSPASITDPVEVATVQITGWEAPSLVPTTPIPSELSSPNKTETWSEITNSQNPDGFVEFESDKWKNSNSKRSIDTQEPPMMAMDRAGIDDQVPQLPEGEYDLSYAQELRHLIFFHFVFLLIVTTTILFMTQIARRVNRRITRCPIELSGDYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2M9</accession>
    <name>A0A2T7A2M9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1121348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2M9"/>
    <dbReference type="STRING" id="42251.A0A2T7A2M9"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="47"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="495" mass="54460" checksum="F8DC363EA4211526" modified="2018-07-18" version="1">MSEGSTIGKDAKYVDGVVTPDSLESSDGASFDDKRTKKLLRKLDWHLVPFLALLYLLSFLDRTNIGNARLAGLEKDLGMKGLDYNVALAVFFPWYVAAEVPSNLMMKKTRPSLWLTIIMLAWGITMTLMGVVTSYAGLLACRMALGVAEGGLFPGVTFYITMWYRRHECGLRMAIFFSAATLAGAFGGLLARGITEMDGVGGKPGWAWIFILEGIATVIVACIAYWAINDYPETAKFLTAEESKEVQRRLKADRTSLADEYDIKYFFHAVKDWKIYVHMLITIGIYTPLYSFSLFLPTIVKNMGYSNKESQLMTVPPYVFACICTIAAGYLADRTKQRGIFMIAACLCSIVGFTMLISTHKPGVQYLGTFLAAGGIYPNVPMGVAWNGNNIGGSTKRGVGIAMHVGFGNLGGTIAAFAYRKADAPRYFSGHGLLIATTSMSLALCCFMTAYLGKENARRDALMVEQGLTLESYSDEMKEAEREKGDNATFFRYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2R2</accession>
    <name>A0A2T7A2R2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1062097</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2R2"/>
    <dbReference type="STRING" id="42251.A0A2T7A2R2"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="115"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="306"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU82033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="760" mass="86094" checksum="2C5C4239EFB89F94" modified="2018-07-18" version="1">MSATEDRKRKKPQEKESQANSLKRHKSEPVSPPSGNTKSEIDPSKNPYLAHLYPAEEDRGPLAGFKRHNTTAKMANIAEEGTFNPFSGNKFSDRYRNLLKGRRALPIPAQRDEFLNMFHESQIMVLVGETGSGKTTQIPQYVLFDDLPHLNGYKQVACTQPRRVAAMSVAKRVADEMDVELGKEVGYSIRFEDKTSSNTILKYMTDGMLLREAMHDHLLERYSCIILDEAHERTLATDILMGLLKNVAERRPDLKIIIMSATLDAQKFQHYFNDAPLLAVPGRTHPVEIYYTPEPERDYLEAAIRTVLQIHATEPEGDILLFLTGEEEIEDACRKINAEVDMLIREADVGPLKSYALYGTLPPNSSKGFSNLPRPHSSQVVVSTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTESAFKKELIEQTYPEILRSNLANTVLELKKLGIDDLVHFDFMDPPAPETMMRALEELNYLACLDDEGNLTALGKLAAEFPLDPALAVMLITSPEFFCSNEILSLTALLSVPQLFVRPPNNRQRADEMKKLFAHEDGDHLTMLNVYHAFKGEENQPAWCREHFLSYRALQNADNVRAQLQRIMERLDIQLVSTDFSEKTYYENIRKALVSGFFMQVAMKNSSGKAYTTVKDNQDVLIHPSTALEKESPWVVYNEFVLTTKSFIRTVTHIRPEWLLDIAPGYYDVGSFPKGSVRTELEKTVEKVRKKNALKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2R3</accession>
    <name>A0A2T7A2R3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor, Prp19-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1075696</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2R3"/>
    <dbReference type="STRING" id="42251.A0A2T7A2R3"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="3">
        <location>
            <begin position="118"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="503" mass="58546" checksum="352289E51D674930" modified="2018-07-18" version="1">MPPKRMTANPMKPLRYRPGKPIAPEELDSEESEGSESEGSEEEPQQPSKKATSEAPAKVSTALRKVDLGKRFEEGRKEEEKRAAGEAKKSAEEESSEYSTAEEEEEEEEEESEEEEEEEEEEAPKRLLLRPTFIPKGKRGAVASSVPDPEVEAKKKAEEEARKKAEAAALLEEHIRRDVAAKAAGRKGWDDDEDDGEGLDDTDDLDPAAERAAWKLRELVRVKREREELEKIEKEREEIERRRAMDPELRKQEDMEYVKRQHEEKMENRGKMGFMQKYYHKGAFYQDDSEILKKDYATAAVEDEVKNRDVLPKYMQVRGDEVGKRGRTRWTHLAAEDTSMQNGGSPWFDKNGINKRASEKLGGMHDDERFQPDDRKDRGGDGDRRERASKGRDDRGRDFGDRRPPEGPRGHRGSDSREGGYQDRYVPGAGGSHRDRSRSPYDRGRRDHGRYNRDRDERYDRDRDMYRDRNGDRDTDRDRKRPHSPPRRRRDDDSEKRRRTEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3H1</accession>
    <name>A0A2T7A3H1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_969064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3H1"/>
    <dbReference type="STRING" id="42251.A0A2T7A3H1"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="325" mass="35236" checksum="9487CF3763784D53" modified="2018-07-18" version="1" fragment="single">YLHHSSLNYLRLKMFSISRAALRSSCQSAVARPLATAFSPSTFVNSKSRPSNLSELRSFESLLQRYNSNYGSGYGGGNQGGGYGNQGGGYGNQGGGGGYGGNQGFAPRNNNGRGFNNAGRTSFENQKLTPTKVVYVGNIQFDVKEEDLLEEFKGFGKVLSTKIIYDARGMSKGFGYVEFETIEQATAALEASHNAVLRGRRMNVQYVHRPNQGANGSSEPSKTLFIGNLSFDMTDADFDGLFTGVFGCQDVRIAMDRATGLPRGFAHADFIDIDSAIKAKEKLAGVETRGTLAVGMPALGVQWSLQWSLPQPLHSRRPSREVRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3P7</accession>
    <name>A0A2T7A3P7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromatin remodelling complex Rsc7/Swp82 subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1099206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3P7"/>
    <dbReference type="STRING" id="42251.A0A2T7A3P7"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="683" mass="75817" checksum="EF726C0028E5700E" modified="2018-07-18" version="1">MPSAAYPSSMFSPAGQSPMLNNGGVLDGSGTIDPATLNPTAFSSHLSTGSHIPPYSPPTSNTTEFDNDSKPGVSALANSSPRGVKRSRSPAEPYRDGAIAGDDLGTGAAGRPPKNKGPGVPQSPNLATTPQQQHQQLPPQAIQPPAQQPGSLPTPPKPPPAKPVVKALPTVRDHTTDQLTPEGDEYVPRETDDEGDKKVLPTGHLCNGREYKCRTFNVPNRGDKLFMLATECARVLGYRDSYLLFNKNRSLYKIIATQAEKDDLIQQELLPYSYRSRQIAIVTAKSMFRQFGSRVIVNGRRVRDDYWETKARKQGFTEEDPAGEKRPGAAKQRAAQASEQAAQQQQQQQQQQQQAAAAQQQQHHEPIYPHDAVQLDQQPQPQMVQPGLGGPAPVPLAPLPMIHLAPEGQDRLKEIYSVPRPKQEITGPPYQDRTVSAAPAQLMEQMHNTADFNKVLRTSSGMRKENYNNYFNKPRSPPVNQPGQQPQPMPSPQQQQQQQQQQQQQQQPTNPPLPHPSQHNPIPQHPQLHAPPHMMNPQQLSTLHHQQQQQAQQAQQQQQAQQQQQQAQQHQIMPQQSPRTTQGIKPEQLHNHPSAAYITPQYFQSPGPQQQPGHPQHHTQQHHPQPHPQSIPAMHVQHGGQPQPPLYSNPTPQHYLGNPPPPQNYRPQPPQQQQGGQWWNTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4E2</accession>
    <name>A0A2T7A4E2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000024">
        <property type="protein sequence ID" value="PUU82617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4E2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40720" checksum="CFE89E8587B41D74" modified="2018-07-18" version="1">MSSHDEIISPPSTCRPARYLRPYVNQTAGPELRNVLGQTLKYMTRQLRQELLAEVSTDTNECNQAIDLWIARLNTIKSGLASFPMVIEGGEANTTTQSPATAPPADGTNQAQHASPSEETITACLERDGYQCILTGRKLSNGSDSKVVPIIPFVFANHPRCRDLAFWKMLEMFYGTEAIDTLFAGLLDRVNSLENLIALDDSIHARLNSGWLTLTPETATRDPIPVINNYRGGYWLNLGYPQGLRLSEHIQSIKGLNAGEVRTLYPRSRIAIECHKAMPNQPPTLPLPSYFALRVFVLTLKNLCAYQLPRHHALAPPGAFLTPGPITPSHYWNEYPTYSPTLDSTSADPILAASAILQALADAGALERSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4M2</accession>
    <name>A0A2T7A4M2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1061570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4M2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="149" mass="16837" checksum="F6927C63B75E361A" modified="2018-07-18" version="1">MHLLQPGQQKLPLCPPNSPALHHYVSLLGTISHSEISLTSLRTYAQSELHLLNNYFAATTARLNALQPLTKPSSTADPTERRHAVEERSQKWAELHAMEKYKAEIERLQENVRRREELEGRLRGLLREVGEALLEREVLAGEGGEIDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4W0</accession>
    <name>A0A2T7A4W0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1061550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4W0"/>
    <dbReference type="STRING" id="42251.A0A2T7A4W0"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="72"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="21914" checksum="6D007DD8AB9737E4" modified="2018-07-18" version="1">MSTPFSPIDLDSETFVYPVETRTVPLGRTLDRHLRPSTPFAQTHQHTPFTDLFPPTAPSPPDAPCTTTLPTCPVCLDSPIKMTYPCRHATCLKCALEIWYTGATKENIAPRDFSCPMCRGLVHRMGVVLGVRGSEEEGDEGCKEVVEIEGVKVAVGGWKSVHWWVGRNCDFLKPIEEEEEEEEEEEYGVEEMQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4X6</accession>
    <name>A0A2T7A4X6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4X6"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="15352" checksum="0DC6BB9CDDFC7FDE" modified="2018-07-18" version="1">MAYTICTDDSPADYPSAFLETGNSQSDTALMRVCHFWPHRTDGPLKVVLLCKIFTPHVDNKITAALSLRRMMPGPNKDIVRTILDLLPNPHITINELFGGATPDGLDPNTQLPFNIADLRALLARIILKDRVLVKDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5X5</accession>
    <name>A0A2T7A5X5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1073549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5X5"/>
    <dbReference type="STRING" id="42251.A0A2T7A5X5"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="3"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="343" mass="37474" checksum="E721B8ABD4479F0C" modified="2018-07-18" version="1">MVSNKRVVFNSVPSGFPVPGKDLILETAEGGVITKNFYLSFDPYQRGRMVGPGEGTYSQEYALHQPITNNGISQIVKSRNPNFKEGDLCSGHTGTEEYTVHSEKTAKGLKKIQNPYNLPLSYFTGVLGMPGLTAYSSLYEIGKPKKGETIFISAASGAVGSIVGQLAKREGLRVVGSAGSDEKVAYIKKELNFDEAFNYKSISTDEALKKYAPDGIDIYYDNVGGEALDAALSHGNQNARFVECGMISQYNIADPKDAYPIKNIWAVVPKRLTIRGFIVGDADFGPKYHQEHQEKVSKWLADKELIYRESITDGIDNAINGLLGLFHGKNFGKAVLKIADIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A602</accession>
    <name>A0A2T7A602_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1189884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A602"/>
    <dbReference type="STRING" id="42251.A0A2T7A602"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="64881" checksum="802F64B20448F070" modified="2018-07-18" version="1">MSNERHRLVVGVDFGTTYSGLAYIHTTEPDYKNIEVIDSWPGRGNTNHVKAPTEISYSQNGATWGYDIPPNGIRHGFFKLLLDVNASATQYDNPRLATSNPKSMESSYANIPLPAGKTAAETTTDYLKLLYTHLMKTLHQRFIRTLYNTPIQFVLTTPAIWSHEAQNATCQAAKDAGFTSRAGDTLIMVSEPEAAASYCLKEIYHERENSDNPLKPGERIVICDAGGGTVDLITYTIEKVSPRLSLYEAVVGSGGKCGSVAVDRAFLNLLESRIGPGFRKWPARKTAPQSSLMRSFDTAKKEFGTTTRTNFWRIPVGYVKDDPKNGIEDAELRLTVADMKGLFDPIVKQVIALLGRQVRDSNKLDSSNKVSTIFLVGGFGESAYLYKEVQAWVRWQSYHIRVINPNFSWSAVVRGAVFHGVEGIVHTRKLKQHYGVKIGVIFKPGVHDEEDSYIDPFYETKYTRDNVKWLAGKGDDANNEKVISIPCGKSFLPGDKRTIKLTLVGCKFDNPPPSAKHWKVDTLGTVICDVSMMPPSAFQIKRSGIVLQKVVSRAGFTVDMKVGSADLELDLMHAGKSYGKATIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A629</accession>
    <name>A0A2T7A629_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1119615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A629"/>
    <dbReference type="OrthoDB" id="5425359at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="225" mass="24108" checksum="613AF58162A12137" modified="2018-07-18" version="1">MRTYEELLPRTLLPRVPLGSAGSLPPLTSPDYLPVEEYSRPLTTTFFSLGVVLCTVLFLALIICCAARLAGRIHEHRRVRMRDRQGLTSGRRMMMMRRLEVLRKGEVLGQETVIKIGTVVVAAEEEEGKGGKRDNIDENGGCDDGKKSGEDLEKGGGGGGGGGGGEEEGGRGGGRSEWDVSGYGEPPKYDAVGFNEKGEMIDAPCSLYPPGVKSMTNGLGMGVCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Q8</accession>
    <name>A0A2T7A6Q8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1142634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Q8"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Q8"/>
    <dbReference type="OrthoDB" id="5213862at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="256" mass="27704" checksum="D56EF1161A7B05E7" modified="2018-07-18" version="1">MWILDLAITPEQHTLPTQRGSSEERNGFLMSVEIEGKVSSGVGYAGQSPGISIDTSVLMDLLNGSKTTAARRDYVSLSRARASPSSCNVKEAVMAAIRKLKTIPSGLTRYPGEDRNVHLLLLTSQLDDGNRFTPGSLSRRLVLWARGEMDSSGWCVLLSTSGPWPNSKDSQGGKIPITVEEIASMLRTGTYLGEARTSSPIYAVREIRESSSWSVKPNTSASSRMKNGTSPSTIPWPELTRPVVEAFGETRTATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7H7</accession>
    <name>A0A2T7A7H7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1060805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7H7"/>
    <dbReference type="STRING" id="42251.A0A2T7A7H7"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="400"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="349"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="511" mass="57378" checksum="2080DC4A3420F339" modified="2018-07-18" version="1">MADNDASQLSESQRQALEQFTAVTAQETKDAIPLLRRSQWNVEIAIAKFFDGETADPVAEAIAEQAAAAARPQIPPPSPLPTPGLPLRAGQRNRGTISPAPRIVPQPTTVSRRPPLLISFLLFPFSLVWRLSNSFISLFYTLFPFLARFRTATSPPSRAQTARRSQNPRDTAARFIRLFEEEYGTETGLKFFEGGYAQALDLAKNELRFLLVVLQSDEHDDTASFNRETLINPEVVEFIKTQNIIVWAGSVQDSEAYQVSTALNCTKFPFAALISRAPSSTGSSQGMSVVSRIVGPTPPQTFVSKLTTAITTHSETLERIRATRAVHEAGRAIREQQNSAYELSLARDREIARARREEAERKTREEELARAKAEEKALLANNRTAWRQWRATTIPKEEPTGKDTVRVSIRLRNGERVIRRFNGDASIEEVYAFVECLEYLDESAINEKTPEKPNRYTHEYGFRLVSPMPREVYELQGKRGGSERAVKDCFWPTASLVVEVDDSEDEEGEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7N3</accession>
    <name>A0A2T7A7N3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_962700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7N3"/>
    <dbReference type="STRING" id="42251.A0A2T7A7N3"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33048" checksum="D1115D8D44E9A370" modified="2018-07-18" version="1">MTYQKANPVLVHLDDLKSGNVDFKSLEEAFGPESLGVIVVSGLPEKFIGLRQRLLSFASHLGNLSQAELEALECPEAKYLVGWEGLLVGFKETFEEFCVMVIDIAGLVARACDKYALRHITGYQEGYLEHVVKTSTSSKARLLHYFPPPALETSSVEAEEDLDNWCGTHLDHGCLTGLTSAMYVDEGSQTLDISRGVDLPELESAPDPDAGLYIKDRRGGVAKVGIPRDCLAFQTGEALEVITEGKLKAVPHFVRGCRASKAAGVSRNTIAVFTQPNLWEKVDRDRDFATFAKEIVAKNTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7R6</accession>
    <name>A0A2T7A7R6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7R6"/>
    <dbReference type="STRING" id="42251.A0A2T7A7R6"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF4">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="20894" checksum="12D8EF62A622B929" modified="2018-07-18" version="1">MATAEATRPETEEAGSNPGSRVQSQAPDQNHSGSQARNESHRSRSRSQQNGNSDRASDDRENGSSEAGAPTSDNEAPARSRSRRGARRRRGKKGPGGNLRSVDESDDDYDEQEQQRAQQQQLQRQRQQQQQQQQQIMTQQQQQMQQQQAGGGGGGRDKPLKLRLDLNLEIEVELKAKIHGDLELSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7T0</accession>
    <name>A0A2T7A7T0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1071646</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7T0"/>
    <dbReference type="OrthoDB" id="4768051at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="646" mass="72572" checksum="361EE05F4931F670" modified="2018-07-18" version="1">MPHRQTLSRRPDATKTPPETDSTEELLTNGSEDPPLEPLDSGDLFYSDLLRLILRFFLTFCSLGLLVICLWQFSGKGPLDKWQQRCFNTLSILLTGIASLGLGSLIGCLGSMLRWPLLARTMHKMQDVDLILGMAPPTGSLWLIWGHLRKGGTSRTTWIVAAYLIINIFGRLSVAVFGLTYNMMDRTGIEYPILSTNWDSVSWAGYYNVSATFTPILYDPGVSDDYWNSVWNGVRKYAKKPKWLASSVRLELYPLTTANSSGLLSELRIENSTLEEPVGPNTVEYSYQLKDYHEGYAIISNHTVHSAVNCSLVEVSSEGQYWRWNNWDRTGPFDWDSDEVLSHVLAASNETYFEYKFNYPYWVSFAYTTHEPSHVYIVCSEIAWECSPTLTETVANKSSQPHQRLFHSASLYALPASGKMGRFTPEDLTKEDNFTYSVYVNQLPSSQTGPNALDGLNGPEPICFPHFTMPLDKIRWNTYTLWVSGLVARLPILAITYENTAHPQYTRDTHSNRTAGTAYLHTTLEVNWNRVTITAASIGVGQILAILIVLSYCNGVYTRDDSHLATAELLKTVITRFDGGKLMTGEELAVSLDRALGVSVSYGTREGQDGGPPEVDLASGLDLNFPPFPHKRRFRRKNSQKIPEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A863</accession>
    <name>A0A2T7A863_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A863"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="19377" checksum="624C335F6CB47FC7" modified="2018-07-18" version="1">MESPTTQTTQLGPDRRFLNAKGQTTYGAPAVWSQLLENNDEKFVSMGLGSTYIGVFFHSDPSFSPSPSPPFPFFPHKPQTSKITQPYKPLTILKSLSTTAQMSLLSILGFKCNAVNFFCCTWHITRTPERTKAREAPITTQPTPQEPMSAKPRGSEGRGFAGVSLVFKGAQDYVNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8C6</accession>
    <name>A0A2T7A8C6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1071225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8C6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8441" checksum="3D72A4EEB4E5697B" modified="2018-07-18" version="1">MGMKKKGRKVLKLIYRARAVFAAGCLLEWGFGVKTAPTCMIALEVIILLLRVSSDTGKVPVLYICGFFGSWVTVKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8E1</accession>
    <name>A0A2T7A8E1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_961912</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8E1"/>
    <dbReference type="STRING" id="42251.A0A2T7A8E1"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF11">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="4">
        <location>
            <begin position="433"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="624"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="657"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="919"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="951"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1080" mass="117525" checksum="452B7DE9C740EB9E" modified="2018-07-18" version="1">MRKPELLQRALARARSSGEDSDNKDSLSRSDKSPPDEESPLMGGEVKICVGCISRERKRAARKKPKQIKEEEEWMMDEPKRAVVFNNHEVREWLPTSGMQSLNGGMDGSGVLGSWEDGMIMELHMRLACYCRHQGEKEGFRVIFTIKNHEDVVIAQQITSSILITDDHKSSAATPAINGGSQDIKLVGTGYQPPQNQPPPNLFGAPVGSISSHDNQQGFNVMGSGAHGSTPQSPPPFSQNSFSPPPPFGRNMSPASPMASTGSRQQSPPPQLPNGNPSTKKRRINSGPKVPAGLTMTRMDNQRPSFQQQNGPLITNSQPSQFQAPALNPFSAAQSPQAFWTDEPMTPSGMSDHAGFPFDSTPNTNFNGLDNRSQFASPQSARPSRAPSPSPQEAFLRAQQATPRIPVHPQGQARHIQTHNFQAVPPEPEASQIPEISRLVPQEGTCRGGIEVTVLGRSFVPGLTVLFGGTPASYNFFFSPTTMVCLLPPNASPGPVVVSIRNVQLGTGADKVRFFTYINDADKSLMELALQIVGMKMRGTMSNPQDIARSIIEGDTGSAFSQGSPRASQDGTSGSQQHQQYLRRLAGESGFGRHGLEGTLLKFLDAMDLDESPYPFRLDLTNKAGQTMLHLASILDMGRFAAALLARGAPVQATDANGYTPLHFAALHRHLEIYRRLLRHNADPNLQTRNGDTAIDLAFKQGSSRGRSQRVTRSRHQSRASSASSENRFGGRSRAGSSASLSAMWDPSGMETGRRGQIGVDDFFGATDESSSGDGDDGVDDRWMRSRRGSCHSATAATAALGDNVLATDRVPPVPGVMAPPAEGLGPAAAMTAWREQIAASIQNLQNLQWNLPTMPTAADYQHIFQNPMAALQNPMARFHALMPPSPFAQDRNVVDSPEIKKGQYTWWELFSAPQAPPAYDELFPHQPSSSRGPPDDIILERGSEVDNAKLPEELVPPSPSGSSSSASSLDVNELRYRIARGVQDMTKEQQDEYRTHARKMKKIESDRRLYFFWLPALILILIAMAMSYGPAVWYALKAIILFVKAVFEDPFSIKESMAAMASGVAVAGGFLEPRRVPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8H0</accession>
    <name>A0A2T7A8H0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_558439</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8H0"/>
    <dbReference type="STRING" id="42251.A0A2T7A8H0"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="103"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="200"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU84036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="32189" checksum="892CFA23AF3BC704" modified="2018-07-18" version="1">MSNTTTGKAKEKPGVARSLIAGASAGAIEIAITYPAEFAKTRSQLNRRLATAQKLPWPKFGKEWYAGCTTAIIGNSVKAGIRFLAFDAFVNLLADENGNISGPRTVLAGLGAGTTESLIAVTPFESIKTQLIDDRKSGKPRMRGFLHGSGVIWKEKGYRGFLQGLVPTTARQAANSAVRFGSYTTIKQFAQSYVAPGEKLGPLSTFGIGAMAGLITVYCTQPLDSVKTRMQSISARAEYKNSFHCAYRIFTEEGILAFWAGALPRLGRLMVSGGLVFTMYEKTMEAFDKLDPERKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8H6</accession>
    <name>A0A2T7A8H6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">t-SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_961755</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8H6"/>
    <dbReference type="STRING" id="42251.A0A2T7A8H6"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="229"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU84047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="41239" checksum="EF785406DD7806AB" modified="2018-07-18" version="1">MWRDRTNLYISYRQSYSHHPAKRPRFASSAFHVDEERRGLISSGSGLGGDADDNFSNNGDAVIEMDLLPPRWADVSDEVNELLADILRKSSKLDRLHSKHVLPGFDDNRSAEEGEIERLTGEITNGFHDCQRKIRRIEGMIGGDGGSKGEETMGRNIQISLATKVQEASTSFRKKQSAYLKKLRGLSGMTTPLDRTGSPNPFYQDSDPTADISFSQSALQQSATLTSNDASIMQREREITEIAKGIIELADIFKELQTMVIDQGTMLDRIDYNVEQMSVHVKAADKEMAVASTYQRRTTKRKIILLLIILIIGLIILLAIKPKSNATLKPPPDPNAPSPPDIPIKDDPPGPRILHRRRRRRRLSWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8J0</accession>
    <name>A0A2T7A8J0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_961694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8J0"/>
    <dbReference type="STRING" id="42251.A0A2T7A8J0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF2">
        <property type="entry name" value="ALPHA_BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="391" mass="44515" checksum="B412323C8F15FD4A" modified="2018-07-18" version="1">MLLGQVSWPDILVFVVFLTWRLLRDIGIYGTVICAVQALPFLCWRMPIDIIKERYLTKLNRQSAFTRRSTLFQALVVACMRYGFACVPTRIGRVFFTKGVALPFLRFRMFRHGYFWRLRHRPLWREINLNKGAMKGIWIVEDDTKKPDVVIYYCHGGGFAMGTCYFYLEFLISWVSILKDSGFSNPAIFAVEYTLIPDKTYPVQLQEIISGYNHVLSITGDPGKVVVSGDSAGGTLILSLLLHVGNRCPLKKPSFAALISPWTHIVSKLNRDTPSDFLSVSRLHTYGRLYAGSEKLWNPMVSPGFCMDISWWRKAMPARGVHFYFGSQEIFYESIKALAKRLSGVGNVVCHEDESLHAWPFAVLFLGTHQEERGRGLRRISSDIAGALLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8J6</accession>
    <name>A0A2T7A8J6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phosphatase regulatory subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_562348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8J6"/>
    <dbReference type="STRING" id="42251.A0A2T7A8J6"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="315"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="738" mass="80222" checksum="1CE806E2A8BB937F" modified="2018-07-18" version="1">MPYTPPALSPAASPAASRSSSISLNDTKSPATTMSNTVMKSTNPPRSTTYMYKNRRTPPITSPSINNQYLPQRPLVQHRHNDSNGSIHRPPAPVDNGMSMPAGAIISPPDSSQNSSDEEEAAKGDGNTSIRGRRRDLGNLELQLKEAIKNIPQRREPSPDSTNPKSPSPTDPQSQGRRLHSRSASETILAYAIDGGSGSGSEDDDEGYRIAPPMVRKKSGEVVKSSLKTPNRSRPSSMPSTPTFPKAVHFDSHIEHVRHFLHSEKPSAVSAGSSPVESYDGETEFPFNGEDPFRSREPPFEWEISLPNFPKDCDSRKHLPVRVERVVLSTDKKNLIGTVAVSNIAFQKAVVVRFTLDYWETVSEVSAEFNNDVRKRHREEGVDRFTFNIKLVDQANLENKLLFFCVRYTSGGQEFWDNNNNINFQVEFKKKAKPQNGKNGGARPLPRSSKPSSSRPRTLPNNFDDDLDEDAGIFEKLKNAELPEPKSLNLTDTTESLARRANPSGNAFGNRYDFGASLSAAIQAAEAVSGKKIRRRTINFDDVDSPYFKSASPPSPAPEEPKVQVVPALKPSSPTSSLPRSSRSAVKDTASLGTPPVSGAGSPTRDYKPAPFTGGKPSIESSSYRELIDNYCFFGSSKASPTLSQGAEIPDKMHNPTNLNPALYSGAVFATEVGPGSPLPETAISPRYVSSPSHGSPPSSLKSPGNASPIPVNYAGFHHRRRASGAFKFSAQTPTAIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8R4</accession>
    <name>A0A2T7A8R4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative death-receptor fusion protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1071032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A8R4"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="55"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="491"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="737"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU84105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1342" mass="148645" checksum="B60297DA70B0DE7B" modified="2018-07-18" version="1">MRKGVGAEWVFAKHSAIVGEMLMALRDRTLSPVIGKAVVGLLAARKAELNDLHRWIECWEEPLSTALRSEEVRGNVQVYALPGLFRLSPECFVQFVQGVWLGRYNQGNVSSESEVNLMSLLCCLKVGRDLGFVDEISDVANVDYSDSLGPTPIQLSSSFISPLLSHEHEHIRLAALTLTTHSPTLTKPLPTSAFRVLKSALPPLHAETDAEVRNLVIGSMRQLIERLGSTSYALDKDLQGLEKSALRLPKDQTIPSKMLGLKESITEAASFLGWYLNFLKTQLAPGANYQRVVTALRILIIIIRSGVDPSLVGPDDKAGKKKGLLHWSPSVQVDLFDKAMKRVLIDCLFNPFDDVRTMAAEVLKCAPDCGGSLRIILERGLRGMNTSGRARDADGVARSIDLWFHFALKCSPEAKFEELWGLTISAQSDQLGAVGLVLRVLELDYLKVAREDFQRAVRERPIYGLLSGLRLIFEGRGIYECAFKGPAGRIIISQILEYCVDIWRMSKDILCFVSPEGYVPQEMVDEEAEEDGDDGMDTQTVMSYCWRAVKESSALLGAIIRNADFGSGPQAPLSKQNFSDIGNVLLEQLLDIRHRGAFSAVSPSFIELCSRCLATQTLSDLPEQWLSKSILQIMGKSNSITRRSAGLPSLIVGIVIADPHPDRPLLRSTFEKLEEFARLPAVLSADGTKVNLPQVHALNCLRGMFTDSRLSSSSQEFLGRGLELSVSCFASEVWAIRNCGIMLFTALVNRLFGKRMTGTTEIRDFLERYPEVASVLLRSLNGEPGIEGVEQLYPALSLIARLEPSEAFDVGAIEPAVMRCLSSRFWKIREMAARSYSTLVSTRHVIEVIDQLLGDAEKSQKQNFVHGRLCAVKALLDRRGADSHEEVLGVLGGYWGTLVQSNNCAVTKASFLSLLNNSNIQQLLKKRPDDLEAQNLLSNLLEYCKTSQEVLREVSRSSTVGRSMLKEELAKSIYNLASYSNDLIPTLIGTMSGEDEELALYTSSHLFPSPLNLDQDTLASLDAILWTIIATHPWDQLRTIAVNLLSEYPPPRGAPEELLQERCEALLTLCTNASTEPCRIAALPAVATLITYLSHPTALLLKEVTKQVGLLGHEDNPFPTRQAAVSAVKALSPILTFETFNAAYFCLYNFLHDDDEDIRKEAAIVVKSVMKAEHTLLPLAAADALVDKMAKSFSEDEEFTREVVSRVVVNGDIKDQLKKVCARDKILFAREKQNLFLSVHGEVMRWAMVLGGLPENSRFIEDTLNAAVGVREFAREMGEEGPAGWMREEDVWVMFGQVAEGLGVIKRWRGDCGDEASEFLAEMKNLQAHELFVERLEKVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A986</accession>
    <name>A0A2T7A986_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1111883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A986"/>
    <dbReference type="STRING" id="42251.A0A2T7A986"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07187">
        <property type="entry name" value="YvcK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="471" mass="51169" checksum="60E1F43352FFEC09" modified="2018-07-18" version="1">MTTSPRKNRIVVFSGGSAANNLIDVFKHLCKDSHPLDFVLPVSDNGGSTSEILRVCGGPGIGDVRSRLIRLVPEDIDGERSAIRNLLNYRLPADPDKARLEWYEIVEGTHVLWKGIPSEKRELLRSFFNHLNLELLRRQRPTAHFNFHSASTGNLFLTGARFFTGSFESAIYLFHSITGVPSNIRVIPAINSNHAHHIAAGLADGSVIIGQNEISHPSASSASLLSPEDTPAGSDAGGSGADEDEEEGDDLPGSLASLRSQNIVFSKGHEDNEELSDRIERIWYINLYGEEIRPPANPKVVSSLGSAGAVIYSIGSLYTSLMPCLVLRNIGKALVESGKNTPKILLLNGSHDRETGPDHQEFTATDFVRAIVRGCTSSMGEKEGGEVGWNRFVTHVIYLEGNGAPIVGTAELKMAGIECMRVYGRKNPDGDGRGMLYDPTALTQTLETILAARTKRPGARRMTVDAYGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9F4</accession>
    <name>A0A2T7A9F4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9F4"/>
    <dbReference type="STRING" id="42251.A0A2T7A9F4"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="235" mass="25533" checksum="8C10645220D50B0E" modified="2018-07-18" version="1">MEQAIKELIEHTNQKLSTLPPGNRLLISVSGIPGSGKTTLAKKVSEGLNAISKSGEVAAMIPMDGYHLTRAALSAMADPIEAHARRGAPFTFDPVSLKLLIERVKAPLGGEGGEKIIYAPSFDHAVKDPVENDIKILSSQRVLIFEGNYLSMGTDVWGDIARLFDELWFVEVDRGVARERLIARHLKAGLADTREAAAKRADENDLPNGDYLVANGLKPHRVILSVEDQDYARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9N7</accession>
    <name>A0A2T6Z9N7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_933667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000655">
        <property type="protein sequence ID" value="PUU72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9N7"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9N7"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19981" checksum="06EC81CE9EA4D750" modified="2018-07-18" version="1" fragment="single">TYDIDSFIAKAKCLSVAKRGLRIQFSPSCLHNISSDIHLCSDVEERLLSGNISSHQVPLHHIPHFYLGLLPSSIHLPLYVFLPSLWNSSSPNSSYISNHHIQQWMDHALIPAILRHYPQDIIQHLPVSFNSASMSIFARGRESGTQSGRFESGKRQEHHYFLPGRFLKEVWEDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9R1</accession>
    <name>A0A2T6Z9R1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1097921</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000695">
        <property type="protein sequence ID" value="PUU72176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9R1"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9R1"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="506" mass="54750" checksum="2803E54174F3461E" modified="2018-07-18" version="1">MAAAVKQGIENTLTKLSLGSNAEPSSEAVKDLKAKFSGVSQGHVFTFYDDLSTSEKAALFEQLSNMDPQRISVITKEALSPPPPAETPKVEPLPEDATASIMDSAKSDINGWYESGLKLIGQNEVAVVLMAGGQGTRLGSSAPKGCFDVGLPSKKSLFQLQAERIYKVQELGAKKTGNSKAVVPWYIMTSGPTRGPTEKFFQENNFFGLSKENVTFFEQGVLPCISNEGKIILESKSKVAVAPDGNGGIYQALVASGVLADLKTRGIKHVHAYCVDNSLVKVADPVFLGFSASKNVDLATKVVRKRSATESVGLIILKNGKPDVVEYSEIDTETAEAKDEKNKDILKFRAANIVNHYYSTRFLETIPEWVTSLPHHIARKKIPYLDTDSGEQKKPVTPNGIKLEQFVFDIFPRIPLDKFACLEVRREDEFSPLKNARGTGEDDPDTSRRDVLSQGGKWAEAAGATIISTEAESGVEVSPLISYGGEGLEFLGGQEIRAGTAIDKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9T3</accession>
    <name>A0A2T6Z9T3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000610">
        <property type="protein sequence ID" value="PUU72261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9T3"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9T3"/>
    <dbReference type="OrthoDB" id="5324692at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="965" mass="108746" checksum="B8E4CABD328F65C9" modified="2018-07-18" version="1">MSHPSYKRYPASASSRQPPYPLHQPYPAHGPQYGAPPYVPPPPPPPPTPPSQFPQSQFPPPGVHGTTHNTQKRAPPVFERFNHRRGQSATSPPPLPPKIPNNPNYQYHQYPAPPSSVSSSSSSISSSSSHSSRRYGSSSSPNLAQSHLDGRPGRYGDRSRDLNIRLPPRGYKPPSVESAPQSPLSLDTLSPDSKHVLDKNENYFPTPTPDIQPRPRQPIPPDSLPREKSPPPRTSLRGGFIYRPLEHEPHTEGSGSWKGSPILSYEGSDEGSGPDYRSESDHDIGPDSSVDSSSEEPGLYARTSPKTPPSGGQDPRRFPQTSGDAERIAIPKDRKPFPQKTPTDPPPVRRESQQYRHSPSPRVTYQPPPFQSPPPQARQSPQQRYRTPPPFPAATHTPPPRQPPPQQVSRDLLPPPPREPLPVCPKRTPVAWGQWFQMFSVPNFDVCANCYYTHIYPTIFAEHFHTVEKASNAEVSCAFSTERVLHRIWPNALERGVLNGLRDYALMRSNIPECSTVSGDPVNGLSSRWWRVTDRSMPRFRCCDACYQDLVMATGFASYFAPANPQPEEEAWVCDLSFPFISGGMLSVSNYQDNIRKDQWDDFVSIVRFRHNVPPCPGSAKVKSGERKWYIPKRPIPGLAVCEACYCDNVIPHFEDKFTEAVTAPQQTLTCGMAALAVKIPWDSAVQKGSFEIWWEAVYARMTLPQCSEKGFTDQVAREWYRLRHLHENLEGFKCCRSCYNSILRPLDLAPHFEPIRFPLQNSTPTRTCSLAPDSPRYGVYMKKLKEASDRKIFDIFLSYVIPRAKIPPCRPKSFLARMKWYGTDEFVVCEECYFEYVRDSPLNSQLTVHARYSPEPQACDLYSPRMKHIWGEACAKRDIKYFARAAIERGEIYCEVLGRSKEINEEIAARKTGPGRLTLYAPDSGGDDSYRYGRPGSGSGIMGVELTELYKELEALQRRWKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9V9</accession>
    <name>A0A2T6Z9V9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 55-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1097630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000604">
        <property type="protein sequence ID" value="PUU72277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9V9"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9V9"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="97"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="387" mass="43186" checksum="4664A64D52E093EC" modified="2018-07-18" version="1">MSGNGLAFGLNLSSKPKKPTAPPKPKKPLFGFTPSDDVDGGEEDEEEGGSVFGKAKGNKKGEKKGVTKRVAAGRDRSVVNAQLSTFNELSKKAEATAKEAEMQVDPSVYDYDGVWDDMKSVDRKKQKAEEADALERKPKYMEDLLQAAEIRKRDQLRAKEKLLQKEREAEGEEYADKESFVTGAYKKQQEEMRKLEEEERLREEGMRKKSQGMSTFYRNMLDKTESKHDEIVAASTSKDPKPELEDRSTPKGKSDVEIAAELKAKGTSVEINEEGQVVDKTQLLSGGLNLGAVKPSKPSSRTGHSAGAKQQPGFQSKNKLQQDLRARQSKMLEDQLAQAQKRALEEEEESKAELERQAKSRKTSADVQSAKERYLQRKREAAAKKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9Z5</accession>
    <name>A0A2T6Z9Z5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1069861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000578">
        <property type="protein sequence ID" value="PUU72320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9Z5"/>
    <dbReference type="SMR" id="A0A2T6Z9Z5"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9Z5"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU72320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17596" checksum="574FDB09F2E9D112" modified="2018-07-18" version="1">MPSDNLPHAVDAESPLKEAELQVLRNQYEKEGQFVGVQTKFNYAWGLIKSDKRPEQQMGVRLLTDIFRDHTERRRECLYYLALGNYKLGNYAEARRYNDRLLENEPANLQSQSLRGLIDDKVAKEGMLGVAIISGVALAAGLVGSALWRGMSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA98</accession>
    <name>A0A2T6ZA98_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1010311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000551">
        <property type="protein sequence ID" value="PUU72389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA98"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015501660" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="17814" checksum="8DA715FEFBD20D53" modified="2018-07-18" version="1">MFSLRIAILIIPSLLILSTFCLAQGVTQIVRPPGTSPPGCIDSYPETFGLKPADHRIPVIETHCIHPRILKVFLQKGLLIDHFGRIGSIVANRQFQFDGPPAQAGAIYTGGWSLCPDNLIALGPQKQFYACASGDFEKLYDRMVEKQCRPIFMNVVQLVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAM8</accession>
    <name>A0A2T6ZAM8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1097086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000512">
        <property type="protein sequence ID" value="PUU72535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAM8"/>
    <dbReference type="OrthoDB" id="5414063at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="58" mass="6433" checksum="F95474A89E183A2D" modified="2018-07-18" version="1">MAMPRHPCRHAPVSSEMRLREGRPKRAQRQFSRQMGGSKCATVDGCVGQTNQSCNCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAN4</accession>
    <name>A0A2T6ZAN4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphatase 2C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1069671</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000506">
        <property type="protein sequence ID" value="PUU72560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAN4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAN4"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="106"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="446" mass="47813" checksum="B82D85F396F6111D" modified="2018-07-18" version="1">MFGNSNPPPANTAEASPPAKPTNPLAPPPLNTAAVTPPSSEKKRTGSISKASAFIASAKNSLSGLGSSNEEKEYEKAIKQDPSTVPVGPHNNSAGDSRPGPKSTFRVGVTEDKNKKCRRTMEDTHSYLYNFLQTSTSNPPGTSSSTGTSASGTDSSLSNEEQVNDSDNGYFAIFDGHAGTYAADWCGKKLHLVLEETIRKNPNTPIPELLDITFTNCDGQLEKLPVKNSGCTAVCAVLRWEERRLPSALPEAPKENGSGNNENAKPAATPQTERQRVLYTANVGDARIVLCRNGKALRLSYDHKGSDENEGKRVANAGGLILNNRVNGVLAVTRALGDSYMKELVTGHPYTTETVLQPEADEFIILACDGLWDVCSDQEAVDLVRQVQDPQEASKMLVDYALGRFSSDNLSCMIVRLDPTGKFNGIKSNDSSEPKEGAPPALAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAQ7</accession>
    <name>A0A2T6ZAQ7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1096953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000501">
        <property type="protein sequence ID" value="PUU72582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAQ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAQ7"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015637490" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="502" mass="54453" checksum="A02578B86A7FD6FC" modified="2018-07-18" version="1">MVKFKSIVALLGFTRLALSIPADLDTTLVGCLSTYNVPTISPSDADYAPTVSPYNLRTPFFPVDVAVPTTAAHVSSALKCAQKFQAKVAARSGGHSYAAFGLGGVNGSLMIDMKKFRELSVDPNTYVATVGAGLRLGDIASGIYNISARALPHGVCPGVGISGHALHGGFGFTSRMWGTTLDNVIEMEVVLASGDIVTVSKDTNPDLFWALRGAGSSFGIVTTFKFKTYPAPNSGVNWAWRWTLDNNAADTVEKKVKIFQAMQDYAVNAPSNIAFRMFTLPAEGHYEVSGVYWGSLADFNTTIAPLIASFPQDGTSDVREYGFIDLLVVLGGAGQLPQPENYNQHNTFFAKSIVSPTKLTSEALTSFFTFHSENADKPPLSWWVLADLYGGQYSQISAQNPADSSYYVRDSFFTFQLYSDLGGATGTYPPSGFDLMNELSRSLTDAQPETKFQAYPNYVDPTLSPEEAHELYYGTNYPRLKELKAVYDPTLLLWNPQAIGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB58</accession>
    <name>A0A2T6ZB58_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1036342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000475">
        <property type="protein sequence ID" value="PUU72725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB58"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="56" mass="6258" checksum="82C578FE0B05913A" modified="2018-07-18" version="1">MVTHVTDSTPRRPETHVSYVKCRFTSRFHSNLLILLFLRPIAHASGVTFVSSTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBD2</accession>
    <name>A0A2T6ZBD2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1096618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000467">
        <property type="protein sequence ID" value="PUU72779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBD2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015586982" evidence="2">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="191" mass="21229" checksum="A36ACBE4D7A77EE4" modified="2018-07-18" version="1">MISALLLLQYLTAAGSCRYSGMLKYGMVSRSTSIAAWDINNHNPSISTYGNDGRIWGPPARSVMVTVRCGGDLPVKVNVLHCIRDYVFFFSHKLAKVAVISGPFFLLLSQGGHSGSYVDIRSCRYTSRLALPSRIIIIRGANLSWYKSPLCNNEPFIYGDNNLLSLFSLPLFSFSLIGNLLFHNKVLNCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBK2</accession>
    <name>A0A2T6ZBK2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000451">
        <property type="protein sequence ID" value="PUU72871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBK2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015550570" evidence="1">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="144" mass="15404" checksum="8EC903E6C2860705" modified="2018-07-18" version="1" fragment="single">GSLCRVFLVLGVYRVLTLKLDSQGVKHVIAKPIYDGVLRHPICPPPKGCPHTSISHGATEFSEGGVLMPVLGVYRALTLKPDSGGVKHAIAKPFYDGVLCHPIRPPPKGHVHTSISHGATEFSEGGFLIVGFLSADFIARFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCA4</accession>
    <name>A0A2T6ZCA4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCA4"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="218" mass="24093" checksum="CB74A24598B1F04E" modified="2018-07-18" version="1">MSEGSRTYASASRRLSDFGSPPQTRLELAEVRCYLEEGLEGVERHQYPNPKSSGTAINRQIREFQLGGPAQYAVFNPVTDEEFTEIDKFATDTTRDSSSSSSPTKELKFSSMGLRRGLANLGRGRFSGLAGQKEGDTAFKPISRKYIRELANVANPNVTQTDPNSFITRATRTGGCKIVRKTVTGAPVKFRSRKPCFGTTKPLGKVILFSTRRTSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCW0</accession>
    <name>A0A2T6ZCW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1005040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000387">
        <property type="protein sequence ID" value="PUU73337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCW0"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1365" mass="150097" checksum="8262BC14E1B37326" modified="2018-07-18" version="1">MADQFQANRAPGPGAAGPPPLPASAKARQFEDEKKRIIASCFSKLDVDGARMLMALVLESYITHCKVIEDGASPSSPPPTDGLRDQKKSRVIVVAVRKTGRVRMHKARENPNGAFQIGKTWNLDDLSEIENYAAPFEKGFTVTIIKPYYWQASSSKEKDFFISSLLKIYKKYTGGKIPKLIGFGGTEVDKMLGGAASLQEGLRDDMGGASPSGSSPISPGPSQFSSSLKPTPLRNLTSAVSMDNMATSPGRQQSPRIKGIDGLRTGPGVLRPSQSSDQLPSNRRPPDLAPPGSRNISGTSAYSAASGAAPNDPPPPPIPPQGPGRQTSNGSSRSGRDRSATREAPLEDERGIRRMPSSERMFRTPSASSHQSREATGQYPYGNGSRGPPPPAAPPEPSPLLDARAPVKKISSKDVASQFRLAANTYAAGGLIGGDRRQRPKTPTTPTAMSRTPSQDPGGQEEVPQIKYPEERRDRDARGGNGSYGAAGAPGERKRSPSRARDLPAPSSNQKSPEKQTEPPSKPEARRATLSSKDKPPTLPSSALRGVSPSRPKHDSLEIPTGPGGSTSPDGLGDGGQRGERSRSRSPNTKGRKRRSVRSTYLNDVDTSRVTVDIEELLREFDWDPQGKVDALEMKIRKEIAEVEAKDVIVNTDGDPRVEELSNLLDKAIQECDEMDALLTLYAVELTSLNDDISHIENQSQGLQVQTANQKTLQRELQNLMSTISIVPQQLEVLKYGSLDSPQALQSIEDTLLALYKAMTTIDPKMARNAPESPVGSGRRGSWSDEGIGSMKALQERKEGYQKDTYSFLARMKQFMTIKFGAEVVELAKNSKNSPTSPELPRLLGHDSAYIALYKFSGLIAFTKDIDLEEYYGLQKLYEKPVSGLFQDEIREHVLSWKKVTKKSVSDEVDLLFTVQEKETDNVAVTAARKLTVKRSQTLAKIRSPAGDHLKNKNQDGMISSHEAFAGALAEMYNLVLREQNFIVEFFQMSSRLPQDFSEFITNSPAAEHRRIGDLGGLRPVEADKAKAKMVSDFMTGLFGFLPQDLQGLIEWAIRTDPLQGVGVLYALETKMAALPDTDQDFLLKMLEKLHDRLAGLFSRFLDDQIKAIEETKVKIKKRKGVIPFMKVFPSFASRIEDQLPVEVPGSSTDLDVRDLVNDGYERINKAMFESLHAIAKESPTVTNSSLDPEDKEQLNYHIMMIENMHHYLDELPLNTTNPVLTVFKTRAERDLAEHLGLYTSSVIRRPLGKLLDFVESVEVLQRSGAEDIPSRQSHSRQVFKKALAHHDGKEIRRGIETLKKRVDKHFAADGGDDNAALMERILAALEKEFIDVHRRALLLVQTVYKEAGLEVEFLVADVVGGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCY0</accession>
    <name>A0A2T6ZCY0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1058068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000385">
        <property type="protein sequence ID" value="PUU73350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCY0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCY0"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF110">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="41393" checksum="BC3D1905FB14DDFF" modified="2018-07-18" version="1">MGGLSSPTPQQLTVESWSMYSVGILLIIGRIYSRCIILNGFRNLQTEDFLMIFNAAMYTILMSAINVSGRTATNLMEPGTLETLTPEDIQARIYGSKIVILLEQSMLILIWGIKGCMILMYNRLTTRLQQQLLVKCVGCYIVVGFFAVELAWFLSCRPFVGYWALPVPMDQCATYQHYSIVQACFNISSDLMMLGIAIPLFLRARVPTKKKFILVGIFGCGIFVILAACLNKYYNFSNPFTTIYMLWYIREASTAVYVSNLPMLWPLFRRVFNIGTFQDRSTPKYDSQPLSNLSSRKKGTLTSLAGSEDRITREPALEIDQRISFTVEEYRREGKGAEVDVELASKESQESIRSHGGGYKAEVSTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD93</accession>
    <name>A0A2T6ZD93_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1004404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD93"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD93"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="41"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="2">
        <location>
            <begin position="271"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="391" mass="43394" checksum="69FCB7F7D9EC60AB" modified="2018-07-18" version="1" fragment="single">GDGSVINWSIYAGLPIPLYDPVPSPGLSHQLTANTMRHPSLGLVDFDSPAHKTALIGPAILRAAESRNSLRQPHLGYIVKPPDEYPDGEMQIRRAVYEQEYWAAISVTRNATGKLEDALRSGDRSFDPDSLAEIVFVEARDESVTRDYLVPYLDDFKSEALRGFSEVWIPKAVLDEGLRRNMVTVPSAVNPGFRFRMANLRPFDVPAAIPAVSVGLLCIPLPAPSSSPPPQQYIEVAFIIPRNGNSPAHPFTDNHSPNEKTSPPSPSLNGFNYNFPVYWMLNWVGMSALGLPSENMSMVLGPPWFALWLIFWAITNVATSFYPLVLAPGIYRFGYAWPLHNIVEASRSIVFDVKSEIGKNFGVLFAWICVSVLLFPVCSLVARKRAERGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDN8</accession>
    <name>A0A2T6ZDN8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_527675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000363">
        <property type="protein sequence ID" value="PUU73605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDN8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015446403" evidence="2">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="20850" checksum="6295B3EC3962FF82" modified="2018-07-18" version="1">MHKISLFITIITALLPLHRAPPLNVLSYPCPSLTIHAFHASKSHRTLYTLTTMQFALSSPFFLFPITVLSIGFDCSLYTFFRCERLRDRERARMVFGRWMDGDRIGQPARPDLVRRLKGGRGRKEREKLGAWSYLHRFFISSQALSVTVTVPIESHNHILLIEKQYFTPNPSSPLSIPRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE62</accession>
    <name>A0A2T6ZE62_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE62"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE62"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="36430" checksum="DD3B536A3FAC4E44" modified="2018-07-18" version="1">MVESSPSAGNSPGTLTIYNNTPDAPRSSDNTEFSSHSSENIFEKMSELISEANRWKFTSPGRLAFRMNVKIRKCRETDTSCYVLVQGAGEGMVDRIEEAFMHYGIRSLVRFTYEYDVEALIIKCVIGVPHARISRSFIQKVTKEIDGIPGHSEFSYRHTGDGELRVLGKRSKQADEGIAPAGTRDAETAWPTLVIEVGDSQSLAGLHRDAEWWLVHSKGLTRMVILIKLTKPPSPLNLHLEQWIMMKDESKTETRTRKPKKPGRALYWDINAAGKVTHHKKHPNLTIPYLTIFDVGHANATDIVISAAYMKQWALHVFKGLNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZED8</accession>
    <name>A0A2T6ZED8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Asm-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_918729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZED8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZED8"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KilA/APSES-type HTH DNA-binding" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="83" mass="9195" checksum="FCFD8014F8F325C3" modified="2018-07-18" version="1" fragment="single">FDTTGQHAPPGMKPRVTATLWEDEGSLCFQVEAKGVCVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKVRHVVKIGPMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEJ8</accession>
    <name>A0A2T6ZEJ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1033992</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000335">
        <property type="protein sequence ID" value="PUU73902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEJ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEJ8"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="137"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="729" mass="80767" checksum="3063BB82B8D2E93B" modified="2018-07-18" version="1">MLFAITRSSYICAQCRYRVLRNVAPGLLRLSLATNSRRNNSTFLAGGAPGPKSKREDVSEDDYMDSLVDSFIESAFSNISLPRRPAPGIGKTDNQRSILQALPNTWEEAGVRPVVAKALLDTYPNTIRPTDIQKRILQGLKAGNSVAVRDLPGTGKSFAIATWVLGLERAVRWEPDRGSSSGLSPTTTAFILVPNADLGIQYYLMIKNLLLASSSQTVSSSIDSFVQLLHRRVDNPELQLNLLSEKPNPHIIIATPTAVLDIISDKSDSVNGLLDFSQATAFVLDEFDALIPRIHPSWFKGQPTLPPSIRVPPPISSTEILLDWVFKRRKREASTQEVKPVQPQLVLSSATLSTQRMTRFIQSSHPLWIGHEGVDSPSLYDLPKASHLLAIGDESSGIDRIVRAVADNIVHHAVAYDISSGFMRDAPIPRTGLWEAEYITKKLEELKLYELENAESSFRAKALKREGDSLALMPPESWDMSSSQAKRAGYPPHIAAGALQTLLEHDKWPRNAIAAISGEASVGAFIKECTKLRINARELTVDNWNRDTEKEGRIPIGRTDMLFDPKIRAYYKERNERDACRDETIVWVAASASVRGLDVPGVFHLYILHRLQKARDYTTCCGRVAKWPFPTLEKDIKDPRSFGGGVRRGVGKVVSLLLEDHVVPAAGLEASSSDHQVITNDGSDRANWSWLEEGLKVAKIGCHFQDYFGKAGEYPCGLEVGMDRRKFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEU3</accession>
    <name>A0A2T6ZEU3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000329">
        <property type="protein sequence ID" value="PUU73989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEU3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="212" mass="24438" checksum="71DCAB6A611E4C79" modified="2018-07-18" version="1">MNESRRNKEKFKEGVAEGKDGNKEEGRDEDREEDGNEESGGGGGGEEGRMRKRMRIEKRKMRNKEEDVNNQAENRECQGKSMWAGNKGSNIQKAEMRIMLEIFDAARHARPFARVAHPFIVRTKTSDMRSGSMQCRKECNSERVGCAEDMESGSSLIVFLLLTWESTEEKTDIQYVEENEPVSRSIEGLEEGFVVYIYSCLDRYLERERESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEX8</accession>
    <name>A0A2T6ZEX8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Caspase domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1093801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000325">
        <property type="protein sequence ID" value="PUU74058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEX8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEX8"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="32343" checksum="B6C21E57C3DFE027" modified="2018-07-18" version="1">MPTGGYMQSHPPPAGAPNLPPQGMQSFHVPGAPQIGWEFSNCTGKRKALLIGINYFGQRGQLRGCINDVKNMSTFLHDRFNYKREDMVILTDDQQNPRSQPTKQNIMQAMHWLVKDAQPNDSLFFHYSGHGGQTKDLDGDEGDGYDETIFPVDFRYNGHIVDDDMHRIMVAPLKPGVRLTAIFDSCHSGSALDLPYLYSTRGVEKEPNIAKEAASGLFDAMTAYSRGDLGGVAQSAMGIFKRATTGRGAEERAKRTKTSAADVIQWSGSKDSQTSYEPPYVSHEIIGSSRHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF97</accession>
    <name>A0A2T6ZF97_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000319">
        <property type="protein sequence ID" value="PUU74178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF97"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="421" mass="45707" checksum="258E31E064C50B81" modified="2018-07-18" version="1">MSPEDTPTLVPNGTSQGVLNGPLQGLPSQEQAAQLHSGHLRDNSSQFSPYIPDTPEEEEIMPSHSLHSIADPDFPESNIGTPITLSAKRNTLQDEPAENDTPPDGYWVKVANSWGVRHAIMKHFYEGVLCHPICPPPNGRLHTSIFYGTIESSEGGSLCQMFLVLGVYRVLTLKPDSQGVKYAIAKPIYDGVLCHPICPPPKDIPGVSGMQAWSPFMTAFYTIQAVDRQKGVTIRAFSLALQNSGGVRPVITKPFYTDVLHHQRCRPPKGRPHTSIFHGATEFSKGGILMPDFLNSGGVRHAIVQPFYDGVLCHPICLPPKGHPHTSIFHGATESSEGGSLCQVFLVMGVYRALNLKPDSGGVEHAIAKPFYDGVLCHPICLPPKGRPHTSISHGATEFSEGGFLMPGFLSSDSIARFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFA0</accession>
    <name>A0A2T6ZFA0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1103589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000320">
        <property type="protein sequence ID" value="PUU74153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFA0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFA0"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="55"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="241"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="418" mass="45466" checksum="3398F71575512ACB" modified="2018-07-18" version="1">MNMLQEPKQDPIPVAVDKGSLQKPLYAHSTHSTSALALADHRAWAWSASIVYDNRGSLFVVLSQFFCSTMGLFTRVLETSFPEQKMHATQILFIRQSITTVVVGILIAFRSVEHAPWGPWGVRWLLVARGFGGFFGVFGLYYSLAYLDLSDAIVITFLTPIVTTFACSLIPYLNETFTKTEFFASIFSLFGVVLIARPTSLFSRDSANTPNDPSTAHSRPAPRSLLPAGEIPTATPHQRLIAVLVALLGVLGASTAFTSIRWIGPRAHALIVMFYFTLAGSIFSLGSLLLIPSIGGFIWPHTLSQWGLLLGIGASGFATQYFLTLGLQIEKASRATNMLYTQMLFALALELIVWGTTPGLGSLAGSGCILGSVLWVGMKKAERANIAKVRAVDEEVGLMNGKVEGEEEEEGEEGIMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFA8</accession>
    <name>A0A2T6ZFA8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1093556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="NESQ01000320">
        <property type="protein sequence ID" value="PUU74163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFA8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFA8"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="446" mass="49691" checksum="0CB0CC88F97F8507" modified="2018-07-18" version="1">MADKTEAPILEALAASKKTTPIQPSKRYVGQRTAVELKRVQKNVGDIEVDAIQLSSRPRRAARAINQIPSEILQDKDLNEAITLLPENYNFEIHKTIWNIRKHGATRVALQMPEGLLLFACTIADILETFCSGIETAIMGDVTYGACCIDDFTARALGCDLLVHYAHSCLIPVDVTKIKTLYVFVTIGIDEKHLADTLVRNFSPGKHVALVGTIQFNAAIHGTKEELEKAGLKITIPQIAPLSKGEVLGCTSPRIPSSVSSEKEGVDALVYVGDGRFHLESAMIQNPKLPAYRYDPYSRKFTRETYNHQELHTLRRDAISTAKRAKKFGLILGTLGRQGNPNTLSNLENRLKELQTPYVILLLSEIFPGKLKLFEDVDAWVQVACPRLSIDWGYAFPKPLLSPYEATIALGLRKEDWNEERGYRMDFYSKEGLGRTRKGESLPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG97</accession>
    <name>A0A2T6ZG97_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1103411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG97"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG97"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31712" checksum="08EB367AAF92B0AD" modified="2018-07-18" version="1">MAAQKVWLVTGTSSGFGNELAHTILKNGHKVVAAGRNTSRLASLKEAGAAVTKIDQNEPLDVLKKQVEDAIAVYGHIDVIVLNAAYVVTGTLEERSPEESLAQYHTNVFGILNLYRAILPHFRERKGGVVATVGSMGASMTDPLIGLYHSSKAAVRNLSLTLDNEVKPFGIKTCLIEPGYFRTNLLSSGTSFQLPETKIEAYSETNEKTKAFLIDRDRKQSGDPKRGAQVIFDVLTSSGCARGREIPKTLALGSDAVKCIIGSNEEFNKRVEEWKSVSESTDFPKEEQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGU2</accession>
    <name>A0A2T6ZGU2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1132719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000278">
        <property type="protein sequence ID" value="PUU74713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGU2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="15771" checksum="A911E7E27882FD56" modified="2018-07-18" version="1">MIIKKEIEQETHKQSGEKVLKTSKVKTGNHQHLTKAHIIDTEQAAKAAGKQKWQKKIVIIKEDGEFYSTGSSIGALGHEDSWYSEPEGDLEGDRQGFDGIVIKDKGREEVRTASRIAEMVANINRVFEEHGRTFRPQVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGU7</accession>
    <name>A0A2T6ZGU7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1092163</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGU7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGU7"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="82"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU74699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="576" mass="64169" checksum="CF8A35881BC4011B" modified="2018-07-18" version="1">MPLHYPSSTPTITKTLTTLLLRQSLPPPPPRTLLLLPRLNLRTMSESARPPNEGGRAPKEGGKRKEKSGKEKRGFELKVPKGTKDWEGKDMVIRDKIFSTITDVFKRHGAVTIDTPVFELREVLTGKYGEDSKLIYDLADQGGEICSLRYDLTVPFARWLAMNPSIQNIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDIAGAYDPMLPDAEILRITTEILDSLNLGSYTIKINHRKILDGLFQICGVPIDKIRSISSAVDKLDKATWEDVRKEMIDEKGLDPEVADKIGEYVQKKGGKELLDELKEDKALTSNDSFAEGLEDMRLLFDYLEVFCVMPKLSFDLSLARGLDYYTGIIYEVVTEASAPPAGKSTQSQQAPISDDPDADRSNDDSIGIGSIAAGGRYDELVGMFANNAKGRVPCVGISFGVDRIFSITKARMTGEVRGNEVEVYVMAFGTGLLKERMEVCRILWDAGIKAEFMYKNKPKLPQQFTGAEKNGVPFAVVLGENELKEGKVKIKEMGLSEGHPEKKGVDVSKDDLVAEIRKRLAQKEEGARAASIEGALQGVDLKEKAPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGV5</accession>
    <name>A0A2T6ZGV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_998584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000277">
        <property type="protein sequence ID" value="PUU74717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGV5"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058913">
        <property type="entry name" value="Integrase_dom_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791:SF5">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46791">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24764">
        <property type="entry name" value="rva_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="316" mass="37116" checksum="E587A33661465D9E" modified="2018-07-18" version="1" fragment="single">PNRVLSIDGHDKLSHFGFEIYGAIDAYSRYIVWCYVGISNRTAVSVNKQYLRLLRTTLHMPKLIHSDKGNFLNTISSIILEIVLLAESHLTLWRANRPDLPFQKAYSYGKSTKNQRIEAWWNILTEAQTQEWKTYFAKLELDGYFNGGETDKSCLQYLYMDLIRSHIYRFIEVHNSHPIRFQRNREHYLLTGQPFLMYYYPQSGKNYQEKVDEKVLEALEKKVENYNLDEYLPESIYLLYGRFLQEDGYPNIFAYSDPRHKDAYIYLRDRVSQYIADGGQVHLASRPAGAAEWIAAEWIAVHKTHKIEIHRGSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIC7</accession>
    <name>A0A2T6ZIC7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000242">
        <property type="protein sequence ID" value="PUU75232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIC7"/>
    <dbReference type="OrthoDB" id="5420477at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="230" mass="24508" checksum="5AD8A92D0326BC86" modified="2018-07-18" version="1">MAPSANSALNPVEPSPLQSLPFSAHSNADLHHSGHLRESPASILSPSARSKPKSWWRAQCILYGIPIDEKATIAELRASLVSAVNKQGGLSANEEILEEAAESGMVANERVQKVDTAVRGVTPVGGKDASVKESVSGSVMEGGKGKGKRLAEKDRDVLKVVKSGPKVSKKAVKKVITKTVVSKTVKVPKKKVPKTEVAPPPPPPPEESLDVDPYEGEPMMWPMELDIDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIY6</accession>
    <name>A0A2T6ZIY6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000230">
        <property type="protein sequence ID" value="PUU75458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIY6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIY6"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="244" mass="26852" checksum="9D40E6E535CC5A5E" modified="2018-07-18" version="1">MASNIPGECCLKGVVHEGTPNGEIVQFAEVETYITRPTSGSSERVILLLTDVMGICNNAKLIADDFAANGYTVVLPDMFAGDKVPLPADRKVGFQLPDWLKDHQPHHVIPIIQKVMGQIRSELKPRKIGAAGYCFGAKYVTQLLSGEIDAGYNAHPSFVTLDELCAIRAPLAISAAETDSIFTRDLRHATEAKLAEIKATYQITLFSGVAHGFAVRCDLANDKQRWAKEEAFWQAVRWFKLHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJG2</accession>
    <name>A0A2T6ZJG2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_330123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000221">
        <property type="protein sequence ID" value="PUU75622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJG2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="20054" checksum="CD5D14479598E35D" modified="2018-07-18" version="1">MRRRLKKEKLDVPYAFTGIILDNGTLSQDAQIQARGCGAVHKKRELHLKVCVRLGCTGTGPVRSPCARPAINTNPTQPLTPPPELTEIQHHHHHHHHHHQGLLYSSNHSFLFFFAFFCGWPRPPPLLKISNIFFSPFTTTRCSADLHTVCLDPSYGLLTKTIPFKDPAPPLFSPLIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJX2</accession>
    <name>A0A2T6ZJX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative peptidase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_312199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJX2"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="602"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="751" mass="82497" checksum="8BD82E0C85FB2071" modified="2018-07-18" version="1">MPSQTESPSAHTRLSSKMKLPNLRKARTGFFGKSGGPSPSIKTDSATSIIDTPETSLSFPTDKSKSNSSVSATRRSSPERPRPSRPTSEIYTSSSSRTDPNGSPPNSVVRSSSVPLSPFAPRLISAQEGQWFHQSVILVFGEVGVPERPIDGTITVHHHLEGYPATQWPVTSGHFKVLVHLDPGMNRLRFDFSASKIAPTSSGIAVNFLPLTSCPPLHLAILLAKDSLGEYECHSDRKLREGNDVRMAKKKFRMAAYLAQLFTGEQMFRHRLGRRCFRLGEEWVADSLSSRDDGVMRSVAKVHILRTQKTVRDIQQREASQDAQGIWDIASEAVEDYFGEIAPAAKRHVAVLVLDAKGELRFGDLRSRSAFSNGLGLCGSRSLYTLPSCLEEVVSAFSDCSRPGDAIGNNDSSESGSFWEIATSAMKNMLEAFISPQPPTQPRDLEHINRTFLMKEPYSFRSKSPGLKFCVPKDESSWPRVDCLRFRYHPCFRIPTDPVPPALPDNPQVYAIENGIVAGAQSGIVLVEICTDGLYRAHREFTRPEREVSLLEDDLRESLPGGHKTRPMKLRIYSAGQGKIVVEDFSTSKSSKVQLPNGYGVAFKSSSLGRPKAGGSEPQQLVLHTVTPGRMLTSIRVFHNSALGGLEFMYEDSSTQVFGRRESSESHEKVEVSDFTLDTRKGESLLGFCVRSGAQVEGIEILTSFGRRSPIFGNPHGGGASNTLIPPRGRSIVGVSGSYTQCVVEFSILYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK62</accession>
    <name>A0A2T6ZK62_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_304409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK62"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="18350" checksum="B3789A0A21BE2498" modified="2018-07-18" version="1">MEKSHYTQRGRKLKLKQGRASVGYLLSFFFHPRDLPLPLRIKVWCRVVMCDGECLVGCLAWLVSWWFVRVVINFPTKWLPVGDAMPIALRRGLGGVFFVWAVRLGILRGISGIDTCYCIVLATAVFGETNRYCGVEWHELYEFMHSDLHKYCSARLADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLP4</accession>
    <name>A0A2T6ZLP4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_990706</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLP4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLP4"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="183"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="13">
        <location>
            <begin position="812"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="673"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="770"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="900"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="948"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU76393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114434" checksum="66610FFA69028BBC" modified="2018-07-18" version="1">MSTSNLLNHGYDVDEDDQDFDTGHLDQDAEGEPDDEAPPAGGQPDDDDEEDDEEDDEEDDEDDEDDDLPQRKRARRPPRNQFLDIEADVSDEDEEDPDEDEEDGAEAGFIADDADRPELSDLRQYPRDDHRHRELDRKHEAEQAEDMEQIAAGFKERHGRSARRRMEDSQVVPRRLLLPSVNDPSIWGVKCKPGKEREIVFSILRKQEELANTKTPLQITSAFERGNTMPGYIYVEAKKQADVMHALQGVSFVYPMTKMILVPIKEMPDLLFVMKKAEITPGTWVRFKRGKYQGDLAQVENVLASGLEVKIRMVPRLDYGNGTDVDDPSGSKRKRNPFGKSGSLAGRPPQRLFSEVEARKNHAKYLSQTSQGMKKLFTYLGDEYEDGYYIKDVKLNLIQTENVNPTLEEVSKFASGGDDGTESLDLHALAQSLKKTISTYQVGDTVEVYDGEQNGLVGRAVSVHGDIVTLDVLEGPLKGKRTEVPFKGLRKRFNPGDHVKVTGGSRFRDEVGMVLRINEDRVTLISDVGMTEITVFSKDLREASESGGMETGGKYDLHDLVQLDATTVACVTKVDRESVRIIDQQGNIRTIMPSQIASKLSNRRPNVATDRNGSEIRVGDTVKETGGETRSGVILHIFRSFAFLHNREETSNAGVFVCRTGNVATIAAKGGRITTNQSTGPDLTKMNPAMQRNGRSPDASAIPPPRTGGRDKTLGQTVTIRQGPYKGLVGIVKDATDTTARVELHTKNKIVTIEKVKLGFKDLHTGAIKPYQDFMRPGGRGDGGGYSRSPSMSSDRPSSWGGSRSPQSNFSGPRTPAYSLGNKTPAWLSSNDGSRTPGYFPGSKTPAYGMDGSRSSYAGNKTPAWNPSSRTPYASDTDRSTWDAGSKTPGRPSLDSFMDSNSTSANPSNNNSSYSARTPGASYNASSPDFIPPSYSSKELSAPTPGGPISAPTPSALSAPTPGPISAPTPRDAYGGAWGGPETAPTPAPYGAAPTPGASGSYGGGGASGGGSRDPRGGYYQGAPTPAAGYGNPRTPGVWAGGDDDEIRYAEPTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLR9</accession>
    <name>A0A2T6ZLR9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/calcium exchanger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1115911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLR9"/>
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    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015673751" evidence="9">
        <location>
            <begin position="32"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="806"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="124"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="744"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="419"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="914" mass="98989" checksum="98BAE0F6B51EE03B" modified="2018-07-18" version="1">MTCLNSTSRLSVILPVLFFLLLNFAVPDVTAKRVHRQQALDSSHSISPKHLSGPSFFESASSPDGSIVGARDMECRRVHEFKDKCKFVKENCEDEEVGYFDYLGLYYCRLEKFPVVSLMIMAGWLVMLFTTLGIAASDFFCINLSTIANILGMSESMAGVTFLAFGNGSPDVFSTFAAMKINSGSLAVGELIGAASFIAAVVAGSMAIVRPFRVGRRSFVRDVCFFIVAVLFGIFFLADGKIQTWECIVMVMFYCFYVCFVVAWHWASQSRKRRRRKERSAREHYAAPEEEETIDDDDEDGGVGETTGLLDSTHDFRALERGESEDNDEEEQEQQAYAELSNSMRITRPPMERHTTPATPHGIRPSLVGALEFRAVLSSLEKNKNLQGSPIHLRRYSDGPFLSLNTSSFSAPGSLVVPGNFGDRHSPEDDPVADPNIGRSRGLSVNDSARANVDHGYFSRSANDSSQASTTQPTPLSSQFILTIDGTSLTRAKTPDFLAPPSSTGHSRGSKYSSTYSEPTSPLSQASSNSLHVDSGSDSGSQRFTESPRLFSSPPVSPPPSIRLPPPSVDSATLGALSTGANWKVLKYWPYHILPPPQILFGTLFPTLRGFKGKSLMEKCLGFIALPRGSQTNDKTPTVVLEPESPASTITGGDLISINGASGSPRHGVSASDGIGPKEWNRWLVSIQCITAPVFMVVMFLADDEVPLLKPILYALLGGLIALALLLALTTPERAPRWRYLLCFAGFAVAIGWISAIANEVVGVLKAFGVIFDISDAILGLTIFAIGNSLGDLVADITVARLGFPVMALSACFGGPMLNILLGIGISGLYMTTISHSHPDADYYPIEVSSTLIISAATLLITLVFLLVAVPLNRWMMTRQIGFTLIGLWVVSTVINLAVELTGLGSKWGGKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLV5</accession>
    <name>A0A2T6ZLV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1129686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLV5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="6"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="268" mass="29149" checksum="F862B763764E40F1" modified="2018-07-18" version="1">MFSGFQSFKNVHIKGSHNLMTLCLKSRRASPASFNFCSSVSSVMDTPGADTIPETLPEYEDAMPMGYAQSKLVTEKLGDIAARTTTLSARVLRIGQVSGDTRSGIWNATGAIPLTVRSAKTLGALPAPLNDEVVSWIPVDVAAGTIIDLSCLPPATQKGAPVFHVSHPKLLSWNNDFLPALRAVGLEFESVKPTEWIRRLKAIPQDASVNPEVKLLEFFEGKYASDEVSSAPYFETVKACAASTTLRGVEDVKGDLVGRYLEFWREGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLV7</accession>
    <name>A0A2T6ZLV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1066634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLV7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLV7"/>
    <dbReference type="OrthoDB" id="5337438at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="193"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="543" mass="59456" checksum="8AF487A73E8D754F" modified="2018-07-18" version="1">MGTSSTSSPSSTLHKRPPTPKSSSPPTSSSRPPVPENTKVKESHPPRRSSLGFLRRSKSGDPVRKPSPSPIVAPSAPKLPEYPLPPSRNGFVTDISDSVAIFNGHAMSNFTESHSSEGVRSPNGPGGYIPGRKSTDSVVGVSGGARYLKSSSVPFTEDPYAKEGSMAHRGRYSYASSAVSTVNSPRRVRRRKDPTPFNILVIGAKNSGKSSFLRFLRQSLALKPKRGHVAPAEELPEAPEEDTTTHSATSTSSSRNAFKSSYLETEIDGERIGLTLWDSEGLEKGVVDFQLRETVAFLESKFEDTFNEETKVIRAPGAKDTHVHCVFLLLDPARLTPGNHYFNKKGDKPDLAGLDDDLDIAVLRALHGKTTVVPVISKADNCTSRHMEELKKLVRQGLERAGIDPLEALELELDEGEEEEVQETKVKRGSLAEVDEGSSSSDEDAPQSSNKSTTSSVSTSRKAKGLNSFLPLSVISPDGYEPGEKVGRHFPWGFADPYDEAHCDFVKLREAVFGDWRADLREKSRDVWYENWRSDRLGARRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM93</accession>
    <name>A0A2T6ZM93_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S10 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1115769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM93"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM93"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_uS10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="13182" checksum="0E9C9EE0C60A54E7" modified="2018-07-18" version="1">MSYNKPEKGEFGDGPKTHRIRITLTSRKVQSLEKVTTDLIERAKSKNLRVKGPVRLPTKVLKVTTRKTPCGEGSKTWDCFEMRIHKRLIDLNAPTEVVKQIIINIEAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZML8</accession>
    <name>A0A2T6ZML8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta centromeric histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1129348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZML8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZML8"/>
    <dbReference type="OrthoDB" id="5406560at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="5">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="92" mass="10314" checksum="C13D1C5CAE4A1C1F" modified="2018-07-18" version="1">MAAIIKYHLDGGYLIPKAPFYRLCQEIVADLTLEQQFRWQRSAVECLQVAAEEFIVMIMTAGALGLAHAGRITLMIQDLKLVNDVMNVMAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMN1</accession>
    <name>A0A2T6ZMN1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMN1"/>
    <dbReference type="OrthoDB" id="10494031at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="23101" checksum="B296A911EEA9086F" modified="2018-07-18" version="1">MRNSYPTPSPSPFGSTYSFLQSSNYQNADIDHHPDNNIEAIREPPRPTKSNIHMDTESLDRVRSLAEWEAGQILGKDYFDSKERMIKKIDAITACLALEPQVGGFVQSANPPSTADFGKGVGGESMSLDKLNSIDDYGYSLGNYIAADPADDSNFLARVSVREMSTFPGYLRGIPPPSGLGTGGTGENPGQGGELEEGYEDCGWEEVVVVASRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMT6</accession>
    <name>A0A2T6ZMT6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000174">
        <property type="protein sequence ID" value="PUU76808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMT6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMT6"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="798" mass="87621" checksum="7B5C58E7AA37FFA0" modified="2018-07-18" version="1">MHNLLFNNALETLLVDDSDAEEVVGRRVVASTGIVVVPLIAHILAGFLGLVVVCLGGLFLVSYNRQNNMASDPGTLGTKMALVAHSEMLSRDFNGIDECSAPDLCMEPRKYKLGTWGSGGEYRLDVVGVGLVELSIWMGLAETLVNIGLLTLLVILYKSSLRWNGLPTLSDTQFVSQIIFSFIPTVIATLLEPFWVLVGRYRALYQPYIELRRGNASPTSSLGLKYTNIPPVLIVPRALRHGHTILFLASMMVIMANILAVAFGGIFDRSSQPVTSDITTVVSTEGYPETFAKDLEGHWLVVNTNVIEGTDLPGWVTDEFYFLPFDWVSDGKTGLRTSKTQGYGGNPTCQLLAGNTFQQTSHWPNEIRPDINVTRPVRWRIGALRGNYHDWLEDLRDTKTSHWQKETRQEISIMMPGSDGDFVRCENTLSMDPKFLKSGTHPFAVEWVCDLYASNRSDQKAMQGCGSLILAGWGRGEANQNKTGNETTTKIQGDSRWGSRVERSKVIGELKYNDPKIFNRSTSVGNFTAQLAMPLAVHWRVLDQKDTLQTSPPSFEDAQQALSKFYKRFFTILLAQNQNTTFVPAGNPSRSGVGQFESIQPRMSIDPVMFYIAVVILGFQLLAGTIIFALTPRRLLLRFPYNLASEISFFHASSALSDVAGTANMTSAMRRRHLKRLGGTYGYGKFRGSDGENHVGIERMSMIRGYKEAVVTTSASSTILEETAMVRTAAVVTSASSSPPGAGEVSVEGAVSAAGNVGGPALAVDWVGTRAVSPVEGGTSMRAVTRPARESRARWLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMX5</accession>
    <name>A0A2T6ZMX5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1051349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000173">
        <property type="protein sequence ID" value="PUU76837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMX5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMX5"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="369" mass="40073" checksum="96CE7B39F4ECF6E3" modified="2018-07-18" version="1">MGEKSKIVVVGAGVAGLTTALLLSKRGHSVAVVAKHMPGDYDIEYASPWAGANYLPVSAPGTREAEWDRITFAELYRLTTQVPEAGIHFQDAIIYRREKDSRSVSANWFSELLKERPWFASIVPEFRRIPKSELPLDADFGVRWKSMCINPAIYLPYLLSQCLKQQVRFFRGTLTHICQAVDFHLTSSAPSSSSNIVVVNCTGLGSSTLGGVTDSRLTPARGQIVLVRNTAPAMIVASGTDDADDEVMYIMTRAAGGGTILGGTYQQGSWSSVPDKATAERIMKRAVKWCPELVGEGKGVEGLDVIRHGVGLRPLRVGGARVEKEVIGGVRVVHNYGAGGFGYQASYGMAEEAVRLIEESLKEEVKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNV5</accession>
    <name>A0A2T6ZNV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1086748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNV5"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="11">
        <location>
            <begin position="154"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="355" mass="39470" checksum="754352A818102F58" modified="2018-07-18" version="1">MGFRPLAYKGLETGSRITASHVISNGGITFVLTSPLRSPSAPGLGAADVALLKEIHEHLATHGDAVKDVSFEVDDVRKVYERAIENGARGVKGPEVLSDEDGEVIVATVATYGDTTHTLVQREGYSGAFMPGFRRAVVGKDPLDNVLPVVHLEAIDHCVGNQDWNEMDTVCDYYEKALGFHRFWSVDDKDICTEYSALRSVVMASPNELVKMPINEPAHGKRKSQIEEYIDFYSGSGVQHIALRTTNIIDAVSNMKARGIEFITVPDSYYKQMKLRLSKSGVRVKEDFEKLRELGILIDFDEGGYLLQLFTKPLMDRPTVFIEIIQRCNFDGFGAGNFKSLFEAIEREQAERGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP00</accession>
    <name>A0A2T6ZP00_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1086682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP00"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="863" mass="95584" checksum="0EF162CF461E65D8" modified="2018-07-18" version="1">MSLSPGSRNSNNLHQDDSSGQGERLSARNPACDLCREKKVRCGREKPTCQNCRSWKTACTYSERQKRDNEASRNAHRFEEVHDRLDRMEATMTRLVAALESSNLASTPPPAFNSRTIISSSRTQLQCGPGTPQTPQPNNGCPLAPTYKIPVRREEQYLGPSSLMTLSSEAGSLAEEQLRLSSPHPRSEVGSGSHRRQGASDSLRVSADGNIGASLESMLSRPEQAETVGALRKLSTISTNVATWFPYYGHRELRMGAGGANMGIPRREVAEDLVAEYFKTIHVWFPIFERTRFEADVNRFYAGDKKLTEDRAWLVCFNNVMLFGMYSKSTSRKDIDASMGRDFFLNAWAAIDDLEVFMAPRLRNVQALMTGAVIAVEISRPGLCWSLMSGAARLATAIGLHRRPPSPCPFSKIELEERKAIFWNVYILDKCLSLTFGRSTCLPDFDCDTELPEGDGKEVFFVNFIALIKLAKIQSNIYMRLYSAAATRQEMAEKEKAIVELDLELRAWWTQSGAVFDTAGGPDATINEGAPMAPLAIFSKLELKFSYLCSLTLVHRMARPDMGIWAQSDSNCLESARDSIRIINEVVECNLDVANSGMIIWLFQYYPFTSFFILFSAVIRNPTAATSKTVDFQLMKNLVSYLSRMQEKSEGAAKLLQIASAFTHVAGTFLKNYGKLELAKEHAGKRKRTSAEEDIPSVSPPYQHHRSPGEEPGNGDNARASRRGFGKGFYGTTAFPAESVEQVFPATPPPPPMHSHSRSHSNSNTESPPLGLEDLPEVDLHAANFLRWPAPDGMSYEPATSAAAPYPDHAFSSAPETGTTPSAFGLDLEALVAEPEGFQLQMEQAAMRGPLDFDWFSWDGQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPP2</accession>
    <name>A0A2T6ZPP2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1128343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPP2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPP2"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20112" checksum="181B1CEA361F59C3" modified="2018-07-18" version="1">MPAEVSSSPPSQEQIEKPINGSSPIQDPTSDSNTNNSVAAPTNTPHNSHTSASLYAGELEATVTEAMLFELFSTIGNVASIRNTTADSEHALKELNYTSMKGGPCRIMWAQRDPALRKTGQGNVFIKNFDTAIDNKALHDTFTAFGNILSYKAAQDEFGNSVDTDLLITRPLRPPTMQSNISMACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ89</accession>
    <name>A0A2T6ZQ89_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1128094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ89"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ89"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="169" mass="18684" checksum="C47FD05A0C1E64B3" modified="2018-07-18" version="1">MRSNLRTGLSYYVSYYEFLSTCLRFVGKTTTVEKTIGVAVEEGMVDNETLGYFLARIHLFLKELGINPEKVRFRQHMPNKMMAHCAADCWDAELLTSYGWIECVGCADRSAYDLTVHSNKTEDAVARISQEDRERLAALQVAGGKVFVEVEGLGCPREACVITGGGGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQK1</accession>
    <name>A0A2T6ZQK1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_141516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQK1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="20667" checksum="A9CC556E212E8181" modified="2018-07-18" version="1">MRSQSPFTAAFYAIPSVHRQRDIPIRAFSMALQSLLKGESICRVFLDVWKALTLKPDSGGVRHAIMNPFYDGILRHPICPPPKGRLHTSIFHGATESSEGGSLCRVFLVVGVYRVLTLKPDSGGVRHAIMKPFYDGILRHPLCPPPKGHPHTSIFHGTTESSEGGVHMPGFFGCMESADFKARFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRQ6</accession>
    <name>A0A2T6ZRQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fork head domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1101506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRQ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRQ6"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="229"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="229"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="675"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="696" mass="76480" checksum="C180CBCCCB33E882" modified="2018-07-18" version="1">MFSTRLPPLKIHQDALGPSSEPGSASTPTFPPSSASSNPLQLTNGNLQPIMFRPPIVGPSSSPSKKKPHSRQSQALNNPKHSSRIPLPKRVLQNTFDRISMPPPEPDAFPTDSPLKKPPISVFNTSFAPMPAAQLRKTQAAFFTSFSSSKTSFGKENVSPELRSSDDHHGGKPLTGLKAAPRRALMEAAPIKEKKILREKNISQNASSSPAKDEPLAWEPPVIVDDGRKPPYSYATLIGMAILRAPSQRLTLAQIYKWIADTFLYYRTSNNGWQNSIRHNLSLNKAFVKQERPKDDPGKGNYWVVGSGFEHQFMKNKNSRKSGSHSKKSSAASKALMLEEMENLSHPEPIIEIHVEHADSTEHADSTDTIEDKEAALEELLTLSSDATRSASPEPRRMPDDDDDDDDLFRPSSPHGNAATRSSPPPPIMCSSPPVTRSQIQPHRDSTPPPMFPSTSRKRKAPPMGDSGYFSSLESSVVRPTIEEDRPRIKRGRAEEDIARIRHSSHESPIRRNTIGGGMSFLTSSPIRNYDNNPMLPPLTPATMLRPRNPPMSVSPATSLRIHRDRVRQLVKSPSRDIGVLEDNPWGAFAELTSGGSGMDNNDSSALDDIETIVSRACFGSPDKRADKRREVRRSYDGGLRSADLLGEGFLEPPDVFGVDVFGVMKSGYEKFTTDGFGSPSASGRPDLGRSHTTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS19</accession>
    <name>A0A2T6ZS19_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1115001</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS19"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS19"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="17">
        <location>
            <begin position="56"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU78263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="420" mass="44949" checksum="252CC18B06A237D7" modified="2018-07-18" version="1">MEKYSQTTILLGGIAIGAGAVLAVGWLSSNRPSEASSERKSPPAKDTEDIRNGLEECIGNTPLIRIKCLSEATGCEILGKAEFLEPGGSVKDRVAMKFMETAEAAGLLTPHSGDKVYEGTVGSTGVSLAILCRARGYLAHICMPNDQSTEKSDLLTKLGAEVEHVPPAPIVDRAQFVNKARARSEEHTNSPSIPGRGFFADQFENEANWKAHYEGTGPEIFDQCGGNLDCFVAGAGTGGTISGVARYLKPRLPKIKIVLADPQGSGLYNRVRYGVMFDIREREGTRRRQQVDTIVEGIGINRVTANFEAGRPLIDDAFRVGDEEAMAMARFLVEREGLFVGSSSAVNCVAAVRTALQMGPGHRIVTILCDSGTRHLSKFWAKAGNVGGGWKMTLEDVLTAEKTRPSLPVSLSGAPSGWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSG3</accession>
    <name>A0A2T6ZSG3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prion-inhibition and propagation-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_86344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSG3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSG3"/>
    <dbReference type="OrthoDB" id="5378478at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0034">Amyloid</keyword>
    <keyword evidence="3" id="KW-0640">Prion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="5"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="369" mass="40309" checksum="411BF1354B6D5719" modified="2018-07-18" version="1">MESTGVTLGITGLAGLFTTCLQLFDLVSTAKSHGSACQTLLCKLEVEQVFLLKWGEAIGIFNSQGPDHEQRNETYNKRLGDILIRRAVFNILSCLKTTLEDTNNLVAKYGLQPLRSDGEALDSSPHQSAFRVTHEKLQRLLKSTQQTLFPRKTRWVIQNKARFELLIAEIRGFNESLGRLFPEVVMIQQENARAEVGESGAASLRLCSLSDAGSPDDTESAIGLNCVEPQTTAVPEIEKSNLLDTIAEENPETSEGPTASTSQECRCGLEISPENSLHVCVPKSLQSSPKDHSGTTLGRIRSCEDSTATATFIRPEPPSTPTSSSPTIASFPRTTSSLSHPHNLQQSFSLPLRGHDSTHIKTLTAETHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT51</accession>
    <name>A0A2T6ZT51_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1083697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT51"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT51"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="24331" checksum="84D3CCEE8D24B49B" modified="2018-07-18" version="1">MESLKAIFWKPDPAVQLRKCNALLRKNARELDRHMQSLRLLETKTKKMILDTSNSKSNSSAQQTRILARELVRIRRQSSRLATSKAQLQSVGMQVNEAFSVRKIEGSIKASTSVMKDVNSLVRLPELTGTMRELSMELVRAGIIEEMIADSLPDDALEEDDEEVETEVGKILGEIMGGKLEQTNTVPSQLEKEEEVEEGSEMGLEDMRERLEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTB4</accession>
    <name>A0A2T6ZTB4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D123-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1083429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTB4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTB4"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="43688" checksum="EB9372D3DBA43300" modified="2018-07-18" version="1">MVHQDPDSHPLTPPQTLHEIFPPVQKSHILNCAFASWHTRYKSITPKARTIPLTPEFLAYLREDGIILPDDEGVSPPAATTTADSDDEEMSAPSNFPPGEAEDEEDDEEDRARNPTQRFPQLHSQIKQTIAALGGAVTPKLNWSSPKDALFMSATHTLECRTPGDIYLLLKSSDFITHDLEHPFDDTDPSDPTPASSIQYHLVLRKYFNMNPALEFRTFVAGRRILGISQRDLNHYAFLGELKSEIRRLVVGFFNESLAGFPDGDFVFDCYVEPTAREGGGERGRRVWLVDINPFAPRTDSALFSWGEILRLRTQEVEEADEEVVEVRLLESGDPEAWGFGTATYSASKLPRELVEAGVQGEEAVWEFARRWKGIMEEIERGEGEGSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTJ5</accession>
    <name>A0A2T6ZTJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1108094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTJ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="26540" checksum="F36F109F14C6793B" modified="2018-07-18" version="1">MTMNIYRSLLRPHAKCVEYVYLHRQYTWYMRQHRQFIKYTPPRTYQRLLYTDSSEGLKPMPASNSEAKGNLSMKTLWDCLGSNDKYRDSEIPRYKAMADITTTMETLFALVDTKFSQLRRDLQGFADERNIQSNQLRVNMVFIQWQLGILSAMVVAIFGLAVYSVKLLMQHSVPRLPPTIPPPTITENGRKVLDTEGEGGTPGIKPCSGEEAGAKGEACSEGGDKPWWHWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU09</accession>
    <name>A0A2T6ZU09_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1047547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU09"/>
    <dbReference type="OrthoDB" id="5348533at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="588" mass="65252" checksum="E3D82B08DB31FA6D" modified="2018-07-18" version="1">MYRNPYNPYSPPSPSEGSALCTLPTEISEQIYRSLPYGDLTRLARVNRALYTSVQSPLYRHAKVTSYERLTLFIRTLNAVACFDKSGEGAVSKHVVTLHLTIDPNASESESPSHNRPTAVMLSRMIGALGRYCPSVSITLHISNGSCNAQPLTSFELETFPRVSTLILAVGFPSISSGSSTSGPPARPSFHQVIPGRRAALESWGRMGSGCNPNAKFWSGIFNGSSFPDLREVEILHDSGSPASQWAKHVEFGEDDLKGLGKVTRLVVNSAPELNDSVLMGALTRAECLKRLELRNIVGLSYEALSMLLPHALPNLTHFTLHIPFRHRSARQAKDQLETYQPLAPTGEANPLPVHLCPLLRAYGRNLQYLEVQAPYLCRDLFLHESEKSKLNEEGVKIDLGGRGGSLCYSRSGVPFHIDRIALEQTVKQVRKQNGERAFKEAVQLNLREELSKNKTKDISSAGAVSSAEYQEEQKKLKRARTIKEQGWQRTVRFREGMCRDGESWEEIGILARLEEENVKWTCINDAIKTMGVYMNGIGSELEVYPDPPHSGRAPGRPFMAGHDYNDDYAGDEDEEAEDGNDAHDDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU59</accession>
    <name>A0A2T6ZU59_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU59"/>
    <dbReference type="OrthoDB" id="5418659at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="13627" checksum="EE9FDD94196B66F5" modified="2018-07-18" version="1">MIEDLHEVLNVGKDGPIDLEQGQVLIETGFGKTLVQIAINADMFQDLLLRSIVQNYISFRLVEQTPFKSVDTNVQDNEEITTLYDQTLGIRPKLIVLIRIYFQKKGIVQSLVFPDWLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUH2</accession>
    <name>A0A2T6ZUH2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1082696</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUH2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUH2"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="6"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU79095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="366" mass="38942" checksum="3A829A2AB741DFD5" modified="2018-07-18" version="1">MANTYKIVVFEGDHCGPEVTKEAIKILKVVEQHSKATFDFQDHLLGGASIDATGEPLTDKALDAAKAADAVLLGAVGGPKWGTGKVRPEQGLLKLRKEMQAFGNLRPCNFAAEVLVKLSPLKEEVCRGVDFNIIRELTGGIYFGDRKEDEGDGTAYDIEPYSRPEIERIVRLAAHLALQVDPPLPITSLDKANVLATSRLWRKTVDEVLSKEFPQITYQHQLIDSAAMIMVKNPRALNGIIVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKTKVNGIYEPIHGSAPDIAGKGIVNPVAAILSCAMMLRYSLNMPSEALAIEAAVRTVLDDGFGTGDIGGTSSTSELGDKIAGALNALLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUK3</accession>
    <name>A0A2T6ZUK3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUK3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="8776" checksum="4CD6776523DADC69" modified="2018-07-18" version="1">MIQFVLKLISCEGLQFVCCFRPSNPSEHPEGSQRQPENAITRQPGPPRPMTAAITVPTGAAPRVQRSDRTSQTASAPSNSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV57</accession>
    <name>A0A2T6ZV57_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1125372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV57"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="223" mass="24910" checksum="D435EFC003720DB6" modified="2018-07-18" version="1">MAVELSKSYENLVADAKLWLEGTKTVSLVLLVKLEESPAYLCPIKNLTSVELDELVFPNLAEIRTGAFTMSSSCGPAIYKGLQVVWMPVGRIFGFLESWGLDPLTKSATANSHTISHSLRNDLYNMRNNPNSGLWLSQLINIDDLNDENIWFDWNDFLDAMEGHIRETAANSCCRSIRDAGQSLRQRLPTFLSSKCCIAELAEREVGILYAIASPGWRFCRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVL4</accession>
    <name>A0A2T6ZVL4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1081505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVL4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVL4"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="324"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="609"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="868"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="795"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="901"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU79538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="957" mass="103101" checksum="5B55AA3B74FCAA2F" modified="2018-07-18" version="1" fragment="single">MFFRGVSLPAERYLPKTDDDEEEEEVIEGDEDREEVAAGGKGFSVYLDPTLLMSSRHLRSVSHVVVSVVRPPAIAPPQDPSQQQQQQPEEKDKKDKKDAAPEVVPASKIIAVARPWDSAPDGKHVALSRLLSAALHLRPGQVGDMIRIEPAPQQVPQKMLSKIKVFPFQGTEKQDGLKWGGGTKRLEEMAVARLQEVLGPHRQRNGTKAMIEEDKTLVSPGESVLEGALTDGLVLPAIRDSPIAAGGILKIEVSAGEGGEASQYIKWVLAADKKLPLEIGSLVPKPTPPLAAVSETLFVPETESDQPIVGVDDILSSVTNHLLSSSSVLLSGAHGSGKTSILRLVAKRLSGAPHFHRIVDPGSLSKFSEERVGTVKENVTRWFTEALWAAGKTGHSILLLDDLDRLCASESENQDNSRVRQIAEVVVATVRKHTSPGGAGGRGGVVVLASCQAKESMHSLVVGGHVFREALSLKAMSKEGRRTVLEGVVGTTSGVLEKGLELRDIAAKTEGYMPGDLVLLVGRARHEAVVRMVDTGESKESPTLTLKRIDFDSALRGFVPAGLRGVKLQTSGASWKDIGGLTETRKILLETLEWPTKYAPIFASCPLRLRSGLLLYGYPGCGKTLLASAVAGECGLNFISVKGPEILNKYIGASEKSVRDLFERASGAKPCVLFFDEFDSIAPKRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDPALLRPGRLDKSLLCGLPNLEDRLDIFRALVGEGGKLRVGPDVSLEELAARTEGYSGADLQAVLYNAHLEAVQGVISEEMRKREALEEEEQEASATGKDAKEELDFLEFVWGDSRKGKGRAAPAVSANRHRERIALLEKLESLKKQSSNNSTSSNSITNAPSTTKTKQDAGTAEVTISWSHVESSLQSTRPSISPEERKRLQGIYTEFIGQRNGEMPNGQGSTEVGGRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX28</accession>
    <name>A0A2T6ZX28_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha/beta knot methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1063717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX28"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX28"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU80043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="27434" checksum="0D8E78CA000E04E4" modified="2018-07-18" version="1">MASPSSPVKKRPRTQSLPSLPSLIAEQAVPISPEDKDSKRLIVVLAQACLETHKVSANGGEKYVLLNSDDHIGVLKKMGRDISDARPDILHQCLLTLLDSPVNKAGKLQVYIQSSKGVLIEVNPTVRIPRTFKRFAGLMVQLLHKLSIRSTTSSEKLLKVIKNPVSQYLPPNCRKVTLSWEAPVMNVREYISELEDNESICVVVGAMAKGKDDFADGWVDEKIGVSNYSLSASVACSKFCHAAEDVWGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXD8</accession>
    <name>A0A2T6ZXD8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SWIRM domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_768017</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXD8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXD8"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="163"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="410"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="638"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="585"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="772" mass="82796" checksum="2D1185D195AEA8BD" modified="2018-07-18" version="1">MDSDNIDFGSPLSGTNAGTPIANNPLGQPHLVADAGTPLGLTPGQPMEDDEQSTGHNPIHSLQLPTNSSDGQRKASPGIPTAGSPANTNAQQLNISPGDGDSIMQGAGDSPQKIDAPGSPGKNGDNAQAEGGQASGAPASPGTEKKKLEETARGYLVEQTHTVVMPSYSTWFDMNVVKDIERKSLPEFFNNRNRSKTPLVYKDYRDFMVNTYRLNPSEYLTVTACRRNLAGDVCSIMRVHAFLEQWGLINYQIDPETRPSNIGPPFTGHFRITADTPRGLQPFQPAPGAVATAGKPHAVTERAASAGPSKVELNLEIRKNIYDASGNKISGSSQANGHSVDSEDGADKKTHNCFSCGIDCTRIRYHSARSSRNQKQIELCPNCFLEARFPSSSTNTDYVRMEDPSYSTVERDAPWTDQETFQLLEGLELYNEDWNQVADHVGTRTREQCVIRFLQLPIEDNYLEEKPEQLGPLQYNRTPFTQADNPVMSVVAFLASIVDPKVAAAAAKSSIEEMTKNLSQTIESSSKKSDQKTKENGPENSATPKPTSPDAATNATATPPVKSEGQIEESMDVDEPETSSTAGGDPLSPSDDASASENPLAKAGTIALAASAARAHALASNEEREMAKLVNAVVNCSLRKLELKLTQFNELEQVLQAERREIEKGRQQLFLDRLSMKKQCLQVQEQLQRAMSVGGQEGFQIAVQAGQVGGQGPRLAFEQPSTSMAAAVGSATSTPAPAGSSSSATVASATVPQMGMKPVSLENPGGYVAFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXS5</accession>
    <name>A0A2T6ZXS5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000070">
        <property type="protein sequence ID" value="PUU80225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXS5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="274" mass="31062" checksum="15CC096641069853" modified="2018-07-18" version="1">MSFYTIPSIHHQKDVPIREFSRWLQRNIKGWSLCRVFLDVWKALTLKPDSGSVRHVIMEPFYDVLLHHPIYPPPKGRPNMNVWKALTLRPDSGSVRHVIMEPLYNVVLHHPIRPSPKGRPHTSILHGATESSEGGRAQTLKPDIGSVRPVITEPLNNSVLRDPIYPPPNGRHYTSIFHGATESSERGVLMPGIFRCLKSADFNPDSGSVRHVITDLFYNVILRHPICPPPKGRLHTSILHGATEFSEEGVIMLRFFSPGWLESAHFKDSSYVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXV8</accession>
    <name>A0A2T6ZXV8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1021679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXV8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXV8"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="489" mass="53736" checksum="B42C1E5E18D53AE2" modified="2018-07-18" version="1">MKCRIKSQLKLLSTHLRPPKPYLHPYSAVTSRHGIHTTTPTPEAPDKASYSTSLARYLTEAIEATGPISLAAYMRQCLVSDLGGYYTAERQVGAGDQFGQKGDFITSPEISQVFGELIGIWVVSEWMRQRRSGEKIQIIELGPGRGTLMSDLWRTVLRFKTMADSVEAIYLVEASPSLRGAQKALLCGPETKIREIENGFSCQSKVSPKINIIWYEDFSFIPQDKDRTPYIIAHEFFDALPIHAFTNTDNGWRELLVDASSRKGQFVAKNGVSKLETRSNTPEFALTLANAPTPHSILLPPLSQRYKDLEKLKDATIEISPESLGLMEKISQKIGEAGAGAALIIDYGTSDTVPANSLHGILKHKICSPFSRPGEVDVSADVDFTALAEQAIKASKKVEVHGPVKQSAFLGMLGIKERTEFLICELKKQNNRWGDGNKDKEKALRSGHDRLVGEHAGGMGAIYKALAVVPVRDGRRPVGFGGEVTGDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYC1</accession>
    <name>A0A2T6ZYC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1079489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYC1"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051988">
        <property type="entry name" value="HRR_RAD51_Paralog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46457:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="351" mass="37812" checksum="47A0646C3F14E3DC" modified="2018-07-18" version="1">MPSTTPSAITAADTTTHLPAAGILASTLLTQNIRQSNIASHLPKTLPTSCLPLDQHALSSGFPYGLLTSISGVSATGKSLIAMHALTTHLLLHFNSSAAWVDTLGTFSPSLLQQVVSSRTSNDSKTTSNVLDRVQIMRVFDIHGLMEAIDELRTGHLDREKRQRVINDSEDEASEEEEPPPEPFNGTRVIVIDTISQPITTLMTTGPLQAQARMVGVTRSLSDLAKRYNICTLLLNAAVSKPGAGGRQQTYTYTQEDNLSSAFSAATSKPALGNVYAHCVDVNILLTRVKVRGRRKIGGSGGGESEDIVMEVLSDRTESGRTGMWAAFGIVGIPFDTLRKKREGRKDSKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ86</accession>
    <name>A0A2T6ZZ86_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1063161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ86"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="39"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="322" mass="35344" checksum="A9FBD3612C4A28D4" modified="2018-07-18" version="1">MTITTSTIEPMRYDVEFKALDGTTLSGWFYPAGENAPAVVISHGFACLKSWSLPAISTALQSAGIASLLYDQRCFGASSGTPRHDVDPELQSSDVHDAVSHLLSLPSVNRDKIGIVGYSYSAAHAVKVASLDRRIKAVVSINGFISGSWLVGLMFPDRPSTDALIWEDRERRRVGDGEVGYLPVCKTAEKSDNVFLPTDDAAEFYLRMQKIEIANGREWRNGVTTQSLLKMRQYNTMEDLKVLAPTSLLMIVDEAFLQSGLPQKAFEAAGEGGEIVREFATIEGGHFDALEPGRGLEKVIEHSTSFLRRVFDGEAEERVVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZG7</accession>
    <name>A0A2T6ZZG7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZG7"/>
    <dbReference type="OrthoDB" id="5402002at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015612646" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="143" mass="15208" checksum="039F96FCC0EDD324" modified="2018-07-18" version="1">MQFLGTILMLLFATLINAAAFPQDTDTAIKDSFTGIHAEQCADGNGYTFSIYGDGNLEGTIVVINDPAAPNLTINAFDADGAQLEGTTLDAADPDGQALDCNTTCQIQEFIEEYKLDAIFFIACLGDSVPPTCWLDVGAGYPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZT9</accession>
    <name>A0A2T6ZZT9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1078280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZT9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="91" mass="10258" checksum="BE6DE074B91BE181" modified="2018-07-18" version="1">MRVLTFFSSILSFSPPYLSFLPSFLPSFLLPSFLPDFPLFQPHFLIPPPSLPPFRPCRSRTFESCSMRQFLPEHNTTPQSESAGLDCTCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A092</accession>
    <name>A0A2T7A092_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglycosylase SLT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1062860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A092"/>
    <dbReference type="STRING" id="42251.A0A2T7A092"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015636168" description="Transglycosylase SLT domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylase SLT" evidence="2">
        <location>
            <begin position="154"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="310" mass="33365" checksum="49EA9E61268A3552" modified="2018-07-18" version="1">MLVKTLLTVTPLLALVVGAPAPAPQDTAVFSPPTVFSPPTFPENNNFTKTTEGAKPNQGAHVLLSKSDSFAKTSGLSGPGSVVTGKGLAWYSSSLTVGNGGYQDPNYYYCFRGIKENFPPFANWMNFHDMFERNQFTTMVKYDSGPEQGAIYNAILQAAQESKVDARLILAVIMQESSGNVRVGCTNNGVQNCGLMQAYAGSVSYDPNNMAASILHMVRDGTEGTTQGPGYVQWISQNSQTAYAGDTEGNPYQAARGYNSGQINFSDLSDPKGATGSYVSDLANRLQGWNGASCGNHYWESCNFPEKRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0R5</accession>
    <name>A0A2T7A0R5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1122349</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A0R5"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="13">
        <location>
            <begin position="593"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="12">
        <location>
            <begin position="779"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="10">
        <location>
            <begin position="1260"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="14">
        <location>
            <begin position="1576"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="9">
        <location>
            <begin position="1860"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="941"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1468"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="964"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1479"/>
            <end position="1491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU81321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2239" mass="252867" checksum="5E7AD7E867272186" modified="2018-07-18" version="1">MTAQNSSTPSNNTTSDIHNYPHQKPPSVSDHASLGAIPHSLSSSSQYRSLHLPSNSDLHQSFSTSAFGQTAHATSQNSPVSGIPDPRSNAAISSSSQQQPSQVPSTSSSITLPSEFTSSAAKPPEGAGGAGSAGPPRLTLGLAYFNLLISTLTESNYENKRKEIRRLLNDSVEINNRTMRKLISNNYSYIMSSTSSRSSPNPNHRLLTETIKEIASSPQDAKEKFADVIAGMANDGEMARDFDLAVFLSHFGLDSLQKCILAVGLKQSQRHDLRNKAYEIIHKSFRSMLEILANPSKHPELKPEGIAFFIDQILGEPVYPFTDNLKRLEISYAARSRYKNMQLPPEILHVTEPIEKLRQQESLVHIFSVLGPESTNSLENCREVLKRKWKVQISENEMTDMLVLMATARNPIEWHADIFVRALQHENLPQSFNWERVIEGLDREGFVLEGTEGLHVILTALQHGNTDPDFPIYKLWGGRWKHPRSQWSILKGYIKAENLDVKRIPGIRKVFSSADFVSSNSSLKLMVATFETHKLISLDAVDALFHLALHESIPPDVKQAAQAELDKAAKFTPELLLCGALMIPKPWPENLEHVINNLFNMFFEGHTSHQLVFWRLWHVDRPFIIGQFVDYHLGNNLNITRILDIAQELRCLSDLLEVKNAPFVLDVGALAARREYLNLEKWLQEMINKHGSDFVTETYRFLRVKAEAEYIQTREGGKPTMVSLRVGPVHTFLTLLDKNHPPMTQDMQEKVTETQRLCIQAYPRLINLGCGMDSIILANNSESNTFPPIVDKEMQQNYKMMYSQETEISEMVTYLRRLKTSSIPQDQDLFACMIHGLFDEYHCYPSYPLQALATTSVLFGSIIVYKLIDDIPLRVALAMVWQAVRDHDPSSTMYKFGLQALVQFKDRLKEWKSYCGLLAQVPGLQGTDIWKIAQDVISGNVDRPTEPSVNGNIDQGEPGAVLTNGDSNASSLESPQHPPFRSLDPTMPFRDPSAYTEPDEEVQDRVLFIVNNVSHSNLEEKLEFLKENLREEHHQWFAGYLVVERAKLEPNYHKLYLDLLDKYNDKGLTAEVLRETYVNVIKLLNAEATLNSSNERAHLKNLACWLGGLTIAKDKPIKFKNISFRDLLIEGFVTERLTVVLPFTCKVLEQSTKSTVFRPPNPWLMAIIRILVELYQHVELKLNLKFEIEVLCKNLDLDIKTIEPSADIRETRDRPAEKEEEGLPVVEDLSLHPQDFSPTSDPVPAGFADHVIVSSVVQHPAIKRILQLAIDRAIREIIGPVVERSVTIASISTSQLIQKDFATEGDEGKMRNAAHIVVQHLAGSLALVTCKDPLRMSMQNNIRALLAQSGYNEQVITDQTITVCVNDNIDIACQIIEKAAQERAIPDIDDGLSQAYQLRKRHRELRTNRPFVSPDVSQVALHLPDQFRLKPGGLSPQQLSMYEDFNRMARVPNPESARNSFESTFPNDFLPSGSTVVEPPQAQQRASQQSPGVSDAGQKEIQSKISTLLSEVRKLAKECREQHLKDLHAEHPLFHFIEAILSNASLAQPNMPRLKDTICTTVASSVCLILYTDTQNQMEVEALGFLLQKVCELSPLTAKDVVMWLSQGQDDERMFNVPVTVMLLKTQLFALTHLDATVARSINAGKPAALEFLSQLLKETVTGQNPLALRADFASSLDAVGSWLKQDPTNKVALELAGDFQDSDREDQDIDLEDREKRDQIEYIFAEWISLCQYLLTTEKNYSSFIMQLHQTKALVDTASSCEFLRTCIEFCIVEYEQSTSTNPTAATNCYIPIDALAKLVVLLVKYQGEGDQKGQAVDKADYLNSTLALIVFVFNHHHETRGEHFSQKVFFRFFSSMLYEYHLIENQMKGYHERILETFAECFLTIQPVFFPMFSFHWMTLVCHRYFMPKLLRLEGEKGWPVFAKLLETLLVYVGAPLKERSIPPVVKLLYRGILRVLLVLHHDFPEFLAEWHFSICEVIPVHCTQLRNLILSAYPSSLSDLPDPFTAGLKVDRLPEVKKAPKIGGDVFRPLTDSGIKQLLDSCLSSPDGLTNAAIQGIVEMLDTEPRKETGLGFATITVDTAIINSLVLYLGMEAIREATAKGGSTFQAQSPHTALFSRFASDLKPQARYFFLSAIANHLRYPNSHTHYFSYLLLYLFGQVQGKSYESDVRQQITRVLLERLIVHRPHPWGLIITLLELLKNPTYDFWQLPFIKTAPEIERLFGALFQHINNSPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A113</accession>
    <name>A0A2T7A113_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A113"/>
    <dbReference type="OrthoDB" id="5290768at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="623" mass="71020" checksum="4FD5FD3B27943DA3" modified="2018-07-18" version="1">MRTARLLNVEWGWTMRNGRGIQTVNQERGFYVHATGFRGDRTDRYWRDDYGRWHNHWWNYPGQEWTPSKRAFFKWNNLVWRTPRGGEWNAMDKYTRQGWKRREDENLEQGGNKIPPSHGKYTKLGYWQEKTKDFNDLAKWKEERDKDHSQLMVDMYKMGFSAFTGWIPEAILGANLWNAQPESQDREPDLNGANLAMVIGKMASDSRQGLKAGVIELMNPKNISETGETTLSVLLARGHYLPANDHILKSFTEADVEEQITKNVFFKTLNAALKAQQIYITCTADLKTRKSPSSATGGASAQSCKQDNTGPQNLKACVPYTSSEAWKHGIGNGRNGGELACYMYKWAARGQLNRHHNEAPFGSEEWEEWGVSSADIITSSVRSHLSGLESYELVNPLSAGTLQTAKSIGRPDTPGVFTIPVCISRHNLNAPIESFTFLSELNPYSPSKHLPCDCGYWGEETERVWREVGLWNEEPEHYRMTLCPRQTSSHTDDRLQKWVAECRLGTKKSGGRRRFGTDSRCGVVTWLLSELRRRGVPAELPEPVRLGIWCRINTGWWSRLTECKEVTANTPWGSILDELDGMVLEVGEEALGKAITEDEFWKQIEETEPVEELLLKPFGIGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A171</accession>
    <name>A0A2T7A171_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_604843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A171"/>
    <dbReference type="STRING" id="42251.A0A2T7A171"/>
    <dbReference type="OrthoDB" id="74412at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="950" mass="103085" checksum="73791320B5195D40" modified="2018-07-18" version="1">MRETAAKEPNDSPLYGFIRFRRRNILIKYIPEETSRVLKARSTVHFQSIVERFNPHDTEITITCPKELRDHALTSACSTHTATASISSSNSSLRQRRLTDIAESADEEEPLKAPISPGSLVPLGRTGEKGKGNQGLAVVITTHDPKSPEGGPGSPVFLDEDGDHLISPRSSTFPGGEELRRKSTNSIRPSPTDIYEYPYTPKVRLGPRPHVESQKRPHTSSERSKTFPSPGEEVRPVASVPKSVQIAPRKSSTSSAGTKSLTSESVKSTPISPASGIPQGLPSPVASPPPTILPPLSPPQPEGPPVLSPEKQRLMKALQLRRETMMPEAKEHVKLDDDTSPEDPLVNIKEKDEAKSIESEFEEDIASNKSMIERKPIEASQESIQDSKELDTGTDQGEININIGAGEQGPQPTEAENTEHRIRRSEGASSVTEEQQAESTKVRGEPESDVETESDQSVEVSIAESRPISVKPVQQPLPNLVKSIYHTSQTTPKPTSPIAPPSQTVPKVLKRAERPQPERVPPTEIPVVETARSVSAPFLKSARETAKPVVVRKVNVGGGGSVLQRIRQLEMLSVSEGGTAAPSVSPPRSRNTSPTPAFPPRPVSVHSNPPIRTFSNPPPQYRASTSYISPTRIQAAPAPELPPQDAASSIPPKLSSLPKIEIIERNNRPELQVTTTITRDEGPISPPPASPPKVVDAPRNSPKERDNSSPLLDPSPTRRSSVDIGSTHSQNSSRRPSVDRPTPSRSSSSKDLENLPEGRPSSTSSKKSKRAKSRRSSSSSSGSSRRPNKSPTTPKSPKSSSGFLRRMSSSLSKKTKEVAAEVISAAAPTPAPAPAPAPVPEPAQSARKTYLLAGWINVQLPDTMLWRRRCMKINSDGWLFLSLTDDENSPQSRKYHIPSEIRTVDLPDVDEQELPHSVRLFLEEGGTLQCACQNGSEQKEVLGVIRSCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A180</accession>
    <name>A0A2T7A180_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1166028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A180"/>
    <dbReference type="STRING" id="42251.A0A2T7A180"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="319" mass="35969" checksum="D1F56916CF2EB28B" modified="2018-07-18" version="1">MLIIYTVTEWRSIEIFTPIRRMVAHTSSRVFVGLPLCRNEDWLTISMRYTSEFLMTVDKLRSIPKLIRPFYAWMFNSTKLIKSNRKKAQTLLGPIIQRRLEEERLAKEIGSVYKKPNDMLQWLTDLIEPRHKTIEDLSELQLLAILASIHTSLSFLNALCNLAANQECVQPIREEIEAVISANNGVVDSRKILKSVTLSDGTRLPQGTRVSAPSAMFSSDPDLLEDPETFDGFRWYKKSLEAEGSAVYNTNLATTSTRDLGLGHGKHACPGRFFATEEMKILLIFIILQYDFLVSKTDAPKVTASIGKYQTATGTSAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1G7</accession>
    <name>A0A2T7A1G7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1076838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1G7"/>
    <dbReference type="OrthoDB" id="5276692at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="102" mass="11314" checksum="82DC54396DBE360D" modified="2018-07-18" version="1" fragment="single">MAASFSQIVLAIFVLSFIGALLVAGFVIVGKLPQWKESARKQLSKNHIDLLPDGRAKLGVENISHEEYMDRMQKAFVGAVNNSHTNLPSKRSTIPERKNPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A248</accession>
    <name>A0A2T7A248_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A248"/>
    <dbReference type="STRING" id="42251.A0A2T7A248"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="12057" checksum="73B15E2F99BA93B9" modified="2018-07-18" version="1" fragment="single">KQMKEVQLHNLGRPNNMRFGPKTYLEGGCEVPNSRGYEYFDRARLFDQFKPSKRAAEGKDQECRPRAETMRHVDTIMGRRRWCFRNVERAGEDGAPQGWTPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A385</accession>
    <name>A0A2T7A385_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tim17/Tim22/Tim23/Pmp24 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_475546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A385"/>
    <dbReference type="STRING" id="42251.A0A2T7A385"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="210" mass="23642" checksum="E51998EFF3B433DD" modified="2018-07-18" version="1">MDVIRQKLTAFILDPANHDLLEILKGARNGLVYGAKVRFPHALVMTFLFRSGTFQEKLTQTLQATKTHAKNLAAFVTIYKTAMFLLRRLSSSTRKERSSDSFFAGLLGGYLVFGRGDQGTVNQQIVIYVFARVVLALAKLSVEKGVIKDPRGRVKGNSWGVFAAVSWGLVMWLFRWEAGSLQGSLRSSMEYLYIDSGRWDSLRNFLIHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3G7</accession>
    <name>A0A2T7A3G7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_968873</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3G7"/>
    <dbReference type="STRING" id="42251.A0A2T7A3G7"/>
    <dbReference type="OrthoDB" id="5358097at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26042" checksum="D14B10084CA7D583" modified="2018-07-18" version="1">MKFYELFTCFLCRGSREKDCVSAGISIPTEALPTPPTASRCFILGLSGAGKSTFLCRIRTGKFQETQPTEDYDAQEIPLSNQIMNLTEIASSDRRNFRLQFIHLAPLSPIGLLFFIDASGRDPETIEKSLEELVYALTYARSRECQVRYLGIVLNKQDLLLGGDDRWREGLEVIKGMVCDTIKVLLSQQQEKQDAPELVAPLRWEVFDHGVSMKTGTGVERILRGLELGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Q4</accession>
    <name>A0A2T7A3Q4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CAP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1061927</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000030">
        <property type="protein sequence ID" value="PUU82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Q4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Q4"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015594611" evidence="2">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="3">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="295" mass="32007" checksum="31D0E51C0A5A6AA9" modified="2018-07-18" version="1">MLNPFPLLLISTLLSGTAVLSTVINPRASAQGSKPGSSNSDPYSNNDLPRFKKEILEAHNARRREFGVTPLSWDNELWKMAKSVTKTCVFKHSGGGYGENLYGSSAGNPKAGVDAFADEVKNYRDDNLIWEGNSPKTKDGSVIGHYTQVAWRDTIKVGCATSDQRCNFPGGPMWFMVCEYWPPGNVVSRQENLYLKNVGRPGQPFKEPSKDANTKVPPYKGKDIKLPESLANDRSGGSTPGGNTPNSHHKPEEHKPPRNSTSSLPPSLQSQGPSQTAKAAIISVTSKRQPTPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3R5</accession>
    <name>A0A2T7A3R5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_430394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3R5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="10395" checksum="C41B9D48AD5431BE" modified="2018-07-18" version="1">MGTKKGALLQLSLQFFIFFYLFFFFKFMETSTKTTRSLFIYSSAICYFFLLLYCAATLPPSVVFLHSVDPFHTIRNIPYSHTKNGPVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5E6</accession>
    <name>A0A2T7A5E6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_966080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5E6"/>
    <dbReference type="STRING" id="42251.A0A2T7A5E6"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="252" mass="28464" checksum="6EBA3768EDD2EBE9" modified="2018-07-18" version="1">MVLEYRDSHNVHVVCAKAPHKAVAGLLLTEGITNENFYGMIEITFILKGPGSYTLRFQGGTVVGRDKNPLQPGKYILSRSDGEPLEPCKDAWLIKTIPPTGKKASRNDAFKKAVRKRDMGCVVTGEPAVNAQYGGWQGMQVAHIFPLALEKYWEDHGLGTTLISYPPPKSPRRINSVQNGMVLRSDVHELFDDYKMAINPDDNFKVVFFVRDIKNIAGRHLSQKLIDDPKRPVDGLLRWHYRQCVLANMRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5V2</accession>
    <name>A0A2T7A5V2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5V2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="9687" checksum="F7C0C41B520D368A" modified="2018-07-18" version="1">MSYLEGFTFLMIETVFSTLKLSLPPPYLDPYECVKEVRASNAPYKQPRNKSESSGDRHCDEKKKKKTSGQVSFFWQNLMARCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6E3</accession>
    <name>A0A2T7A6E3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1039733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6E3"/>
    <dbReference type="STRING" id="42251.A0A2T7A6E3"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF5">
        <property type="entry name" value="UDP-GLUCOSE,STEROL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="4">
        <location>
            <begin position="122"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="5">
        <location>
            <begin position="475"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="732"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="978" mass="107419" checksum="5EECCFB196743729" modified="2018-07-18" version="1">MSITMEPNAPPRPRFPTSRSLRKTWSPAPTSSRPPPPHQSRFSYLDISHEEFNTHAFVHPRDGRVHIALNKLNDGPLSTLLSKINSGGEEEEEEGDDVRGTGEKEKEKEVAIDEITPPKLNIVVMVIGSRGDVQPFVAIAKVLKEKYGHRVRLATHPAFREFVVGEGVDFFSVGGDPAELMAFMVKNPGLVPSIETIKAGDVARRREQMFALFQGFWRACIEPNDGSKRKSGSRGESVDGVGDSGRKETETSPSATEEAVNGDHNEEEEEGEEEDYPFVADAIIANPPSFAHVHCAEKLGIPLHLMFTFPYSPTQTMPHPLAMIQGSNLGKEYTNAISYPMIDMMTWQGLGDLVNKFRQKTLKLEPLATLWAPGMISRLKVPFSYLWSPALIPKPYDWGDHIDITGFVFLDLASSFKPPQELANFLDAGPPPVYIGFGSIVVDDPDALTKTIFAAIKSTGVRALVSKGWGGLGSEESDIPENLFMLDNTPHDWLFSKVSAVVHHGGAGTTAIGLYHGRPTMIVPFFGDQAFWGAMVANAGAGAEPVPHKDLTAEKLADGIKKLLSEECQLAAGEISKQIREDDGDGAENAVRSFFKAIEALKQGKRGLGPGIRCSFLEKVAVWRIRRTRVRLSALAAWLLVQGGKLTWEDLRLIRHTEWNDYDGPGEPFTGGISALASSITGVAKGIATVPYSWYKGARRLGSEGLDTASEIGDKCKSRSHSHSAAKPTPPNTESEPRQSTDSTDPNGWKTTSTSSSCSRQNPPQDTIPIEVAKNTSRGLSKAARAGARAPMEISLAISQGFHNAPRLYGDEVRHPYRVTGFHSGLRAAGKEFALGVYDGFTGIVSQPYRGGKEEGAKGFVKGLGRGVAGGFLKTSSATAGVVGYTLKGVHREVRKKRDKEVSERIRRERIRQGEAEARELEKEEEEQVREVRERIRRGWEHVEEERRVLEARDVGVRDRVRGRLRRRKAHAAVQLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6Z2</accession>
    <name>A0A2T7A6Z2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_52344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6Z2"/>
    <dbReference type="STRING" id="42251.A0A2T7A6Z2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8357" checksum="55A777620600FF2D" modified="2018-07-18" version="1">MLYDRARITASDTTGDDYIVCSSGTAGSLIAARLAEFRDVSVLLIEASQYNSLLENTQVAGRYVNYIEFLSFATTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A711</accession>
    <name>A0A2T7A711_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000010">
        <property type="protein sequence ID" value="PUU83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A711"/>
    <dbReference type="STRING" id="42251.A0A2T7A711"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="25944" checksum="8955774B8D3DCFB0" modified="2018-07-18" version="1">MSFHSDQTRGIQKQYFESLGLLIIKIALKTHEQVTCHLYHRIHRQATLMENVDNKLSSTGSARYQPTRTIYSSSGKEADKGITPHNRRPDPQGWPTLISESGISESIARLHADAKWWLTQSNFQVRAIVLAHIQVAELVIDIKIWRMHKVQQHRPPTIAGTEYEPKCDQNGHLHIDSSTIPATTVGTLPLFVFTFDDLVLRGRNLDEGDFALNYYDIQSIARVFLTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A782</accession>
    <name>A0A2T7A782_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_955112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A782"/>
    <dbReference type="STRING" id="42251.A0A2T7A782"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="160" mass="17414" checksum="94D6D28A0AA79ACA" modified="2018-07-18" version="1" fragment="single">LIVAATSNRVEIVRLLVPRADVDVNSTDHRRTTALAYAGMTALHRAVFIGDQSIVRLLLDDPRVDVNLGDRTQYTPLHLAVKRGNEPVLRMLLDCPKVDVNALNAAGCTPLEFAVAKSRKAITGMLISDPRVNVNLPDPHLQTPLSIAAQRARVSAVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7B9</accession>
    <name>A0A2T7A7B9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_821705</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7B9"/>
    <dbReference type="STRING" id="42251.A0A2T7A7B9"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000211">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="140"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="233"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="336"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="642"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="498"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU83605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="696" mass="75112" checksum="E53B16A4A587C10B" modified="2018-07-18" version="1">MSAEVSSSPAPQEQIEQPINGSSPTQDPTSDSDANNSVTAPSNAPHNSHTSASLYVGELEPTVTEAMLFELFSTIGNVASIRVCRDAVTRRSLGYSYVNYNNTADGERALEELNYTLIKGRPCRIMWSQRDPALRKTGQGNVFIKNLDTAIDNKALHDTFAAFGNILSCKVAQDEFGNSRGYGFVHYETAEAANNAIKHVNGMLLNEKKVFVGHHIPKKDRQSKFDEMKANFTNVYVKNIDPEVTDEEFRTMFENYGPITSASLSRDQDGISRGFGFVNFQEHQHAAKAVEELHESELKGQTLYVSRAQKKHEREEELRKQYEAARVEKASKYQGVNLYIKNLDDEIDDERLRQEFAPHGTITSAKVMRDEVSKEDKDAEEKEGEGGKKKLGKSKGFGFVCFSSPDEASKAVTEMNQRMVNGKPLYVALAQRKDVRKSQLEASIQARNQIRMQQQAAAAGMQPPGFLGAQMYYGPGQQPGFIPQGGRGALPFPQPGMMPMAGGPQGGPGGPGGRGPQAGNFVPNAGRPGPQGPIPQGIPQQMYGPPAMGPGAGPGGPGFAQYPPPNPLAAAQAQAVAASQQGRGRGGVPPTGMQGLQQGIANMSMGPRGPVQPGRGGPRGNLPPQAQPGRPPVPPQIPHVSTSGIDPTLFAASPPQAQKQLLGESLYPKIQRQHPELAGKITGMLLEMDNMELLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7F0</accession>
    <name>A0A2T7A7F0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_962762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7F0"/>
    <dbReference type="STRING" id="42251.A0A2T7A7F0"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="32162" checksum="EB4246C1DF5D3533" modified="2018-07-18" version="1">MLEAIYITRHGFRSNWVTDNQGNYSAMITSPTGIPSDPPLAAHGTEQAKELMAHLVKLDPKIDKIYSSPFYRCLETINPTAEALDLGILVDNGIGEWYGVGRFDHPSPASPELLHTFFPRVSLSYVPTIIPSTKGETIAQVHDRTAYALARIIADIDRGWAEEGKGPKAIIICSHAATNIAAGRALTGDENFDVKTGTCSLSTYRRRKAPTSPIIVPLPSDEFPVPDTAWRGGNGVGGGWDNVINGDCTFLKNGEERNWWFSNDEAWDSAVVKQKPGKASEGGPGSAPQAGQMEAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7R0</accession>
    <name>A0A2T7A7R0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1060697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7R0"/>
    <dbReference type="STRING" id="42251.A0A2T7A7R0"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="50"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="252" mass="26688" checksum="E3BE31C43C5D195E" modified="2018-07-18" version="1">MSTKAAQRDLTNDLTNVPPEPINPEKVAAPRNEKVSADAAKEDIKSDGDSGEDAAKIAKKMSGIIDPAIDRLKPILQTITEHVDKANNTKKEDLDEEKLVDQLKPLIQQATGILQETHGAIKALDPGGKVGRNAQHKAADSEASPEEQHLARGLAELTGDVTKTIQNAKDKIKDMPTAQKNLGPLLDLLGDPLFQIISAVGLLLNGVLSLLGNLLDALGLGGIVRNILGGLGLAKVLEGLGLGKWLKQPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7V1</accession>
    <name>A0A2T7A7V1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1104924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7V1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="17408" checksum="A09A638FE5A39699" modified="2018-07-18" version="1">MASFGVKRPFHQDFCLSHKYTEHTHSAYDMSLWVLTQPHLAPGLPIVSSQSHQSSHQTDPTSSPRLYHPVPQTRLRSIPRTTYINNPEISPPADVTANSRPHQTPTHTGTPHPSVHFRTPICAPTSPITPAKAARIPRSHLVTPPETRSGRHPIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7X2</accession>
    <name>A0A2T7A7X2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_962479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A7X2"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1328"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="823"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="462"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="589"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="828"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="864"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="962"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1021"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1063"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1113"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1126"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1189"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1214"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1255"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1331"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU83802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1440" mass="158635" checksum="89CF6577E677BD97" modified="2018-07-18" version="1">MAGRPISKIAPVGSMTWITNERATIRQLGEQDFEDFTFSARGELEWLNEHMADIFERSQVDMTELLKTPGRLRGKTPRTARQQLRQVEPFGDVFGANKPAAVLPAGDDRFYNALSQLPSNGSRVSPAREKSPGSKSPDRLVRKQQDVAPPKKVDGTMRDSGIEYSQVEGPATQVNDSGIWSASSEYASQQSLYPSRRKSTPADGPVQEEATLPSPPPPRAPKRESDGRTTRQSFRTAHESEASSERPHSPVQKALKSPVRSPGKPKSQRVSPAKTISLSPKKDAAPAPEPRRSGRLRGGRGSTNSELPDEVPPPSSPPVTQPTPPQEKAESLTEKIANDGYPQPLSEPAQAPEPGPAPAGTPMRQAKEIPQAETQMTPASERSGSGSPEPVIRKSILNFASLPAREPLTNKKKSLGVRATRESHLEQLRANGTSRASWMNRKGNGKSLGAANRPVDTMANSIEDRNEDEPKPVEKSLKRKSEQQDTTRSRKKSKSINPVEVAAQGEDSNGETEKDKALHNKISTQRLHEKIQQLGKVKAPRETHSVSVLAAEPAYPDLSQLKQDQPPAPARRPKSTHQSEPTRPVTGELPRELEKVGEKTCLESFTKPSLARSHTEPRLGVEEEPIRRPDSPKKTQTARMATLTRTMSDVSAPPPRSPAARPRLSKSFSEVQRQEPDLQSPLSPGGEGAISAVKTHTASVFKKAKEMLLKSSVSSASAKIESLSPAPRWQSINTVGQSTKASTEVERSQSSAKSPVEQLYPDLNSVTRAQQFSDEVSVEKTAEKPVVSAKEARQTSNPQSKEVAKEEVEKAEKVAEEVALDGAVAVEPVKEDCQTRDPRPRETPREEVAELAPLMKSPRKLKNAAREEELRQVREQRRKHQEEMLRKEREELRRRQQAEQQREKEEQQRKAIEVSSDSSSSSEDEEQEGAMDREENRGRFASSVEPERPPSRLQKAGSRFQKPAENKRPSRPAKEAPKSKPAPVNIRIGTASQREMQDQRSKMTAPTGSSLVSALKNSFEPSLNASASQSSLQSIPSNSSMRSGSNTGTSKQLKSLTAAANQLKKEQEERERKIAAKREIERRRQENQRRQIQEEEQKKMRQKPAQAVPPSAKTLSRIQSVANLRQKSEEPENKRLEYQTKAASFQKSNASKRALQQESSSDDLQNARLAPPKPGGPAYQQEGAKKRRTGDFEEERPRPAKEMAPPIRQSAVRGGLGQKGGLPHGYIPASQSAFSSTAPSMLRPPTKPGGVPHVEGVKFSKEKLRFAPAEASAPASGPSSSDPAPNPTSNSVAFKTPGASKSMRPTKTPAGVKESPIYQNGELIELPEIPTDSEDEDDHDDYAPKDTFRVPDWAESPELRAQLQRQQTMNPEEVFGPMARLDMEAIFTNRNERQMARFRARTSSANWNGADRLTPAEIAADHEARLRMIEQGGWVYQPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7X3</accession>
    <name>A0A2T7A7X3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dilute domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1071727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7X3"/>
    <dbReference type="STRING" id="42251.A0A2T7A7X3"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="393"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="830" mass="93370" checksum="75259301645D15E2" modified="2018-07-18" version="1">MDLGDPYDDDSSFDVGTIHPRRPRVLPPDLPRSLNDRRRTPPLTSETEVYDAWQGEAQFITAPVPARLNFNLDPDYPEDDDDEELVKGIADSDSRLVSMLAAQEAFRMGGSGLGDEDDIVRNPNLSEEEKRESLQKALNMAASSGDEARIRRILEGEGRNYVDVNAPDEEGTSPLIYASCFGHEDVVSALLDAGANVDQQDRHQWSALMWAMTNRHKGIAKLLLDHGASPEIRSSSGRRAFDFVSPNSEISDYLHRSGYIGTAGVGDDFYDNGLAQERFEEEMAENEMKRRMMMESAINLEVDLSSLGLDERPESPGDEEGDELQDFVWDKCLNDQMFVFQEHELNRMLDVVITNMLPQRSPSQKPVPANVLFLSARYAHYHSSPELLSRLLLSAMDKINNVVEMHQLDMTILAFWISNANLLLHYLKKDAGLVGATVEFQQHLSELINEIFILILRDAERRMDRVMDQAMLDHETIPGFEDVHFQNEWRLFKPKRKSPEPSMLEKRYRPPSPKQRAKPAPRNITSLLSSTLFVLDLYDIHSVIISQVLSQLFYWIGAELFNRIMSNRKYLARTKAMQIRLNVSILEDWARANNRQPEHYESGALTTSGENVVDAARRHLVPVIQLLQWLQCFSSLGEEFDALKSTISQLTRLNPEQLLHSTKNYRPEVGEKGLSREGMRYLVELKMKNYDKKHSRAKSLSTAPKKGGSSNTTPTSPVTGSNALSQNQPPSSPLQNSNPTIVINEDEEDAPEENLLLDPGLMLPFSLPTNTDMLISYGAGLGGMNREREKKYQPSVPPEYLAKLDFSNGSTRNGGGGGSGSGVSGWEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A898</accession>
    <name>A0A2T7A898_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS19c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Small ribosomal subunit protein uS19m</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_961960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A898"/>
    <dbReference type="STRING" id="42251.A0A2T7A898"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_uS19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU83935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="11167" checksum="9D653F06F359A4CD" modified="2018-07-18" version="1">MFPTRVLLKRSIWKGPFIVPYPLQDLSNLEPGKKPLAIQTQARSCTIIPPFVGQRFQVHNGKDYIEFMVTEEMVGHKLGEFAPTRKRFNYKMSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8D4</accession>
    <name>A0A2T7A8D4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8D4"/>
    <dbReference type="OrthoDB" id="5297217at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="528" mass="59401" checksum="C860ADBA9A24BCCD" modified="2018-07-18" version="1">MRLPVEIVDQIMANLIEKKDLAAAALVSRACNRSATPLLYRDIEIEDSLDYNDTRTIATRGVQKRASLPQMTSLVSTLNSNPFICSFVCSIGHQFYIADPHVDSLQRQLWEMALIAMRLQLQEIIDRNGFSRVTQLRLFNPDVEFAEILLKGLLPQIEVLHIASSFVRYLPLDGRLPSNVKELQVQFLSELFRLPGPALFGEAWQKMRAEYNSADEIMYSHFNSFLSSSPFLQILRISGTKELHAILADVILPSLDTLEIGPVFNRVIDLTVAGLSSFIDRNPSISRLALRNLPAETDTVLSISSESRSGIRQLISCVDEIPTDYYSFLAQFEGLDTFKLQRDIVVGGILQDELLELVKHLQRDGPGIKNLALPMPSHINGWTLTDSKLEMARIALERFGQAFKEYLPNVEVFGISQIGRYSDLRAVDWARSFAGHPSLKRLAIKTPLLPNFRESDAVREDAIDDLAKAFSGLPALEKLVFYESVDKQAIEVEILRAETTSGRENLVDSAEVDAEFFDSFFQTGWEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8F4</accession>
    <name>A0A2T7A8F4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU84021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8F4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="17676" checksum="F8ACC22502EF8561" modified="2018-07-18" version="1">MAGVPKATQELMLRNLRETIMDKVNQENRVLKERREGFADNHEAVHAELERQLSSRNPRRPAAREPTPINTGARGLVGRLESQLERELSSQEPRRAAAREPTPINANGRVLEGHQESQDASQESAKSFDFSQSAFARALRGLDAESVTFDDSLDLTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8V5</accession>
    <name>A0A2T7A8V5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_951887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8V5"/>
    <dbReference type="STRING" id="42251.A0A2T7A8V5"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="9"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="49"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="85" mass="9411" checksum="65E18C12865B3741" modified="2018-07-18" version="1" fragment="single">SLLRLPDQDGNTPLHEAAISGHFSMLKALVKKFADHSDCHNEIDKKNHSGNTPLHLAFQFDHTEIVELLVNKGADLTIKNNALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8X3</accession>
    <name>A0A2T7A8X3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1189104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A8X3"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="662"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="702"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="898"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="1172"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1687"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="828"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU84186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1714" mass="190627" checksum="63E9B4A25F83475B" modified="2018-07-18" version="1">MAKIANVCNTRAAQCSILGGFSGNNDSNNINTTITNHFGIQVPSYIPATFEELIARTGWGVSPPEIDLDHLHDEYNLPQGNTGKWIFEDVGYRVWKESRESKLLWLCGGPGTGKTMLAKGVAAEFLRGRDLDRVKLAFHFVSPELPTDGNSADEDQLSQLRLAKVASDLLYSILEQDGSLFDGCKTELGKQGDKFFTNAYSLWKVLRKTIKDCQRDPVYILIDGVDGLGGSSHEELIGRVLGLMEIGIVKIFLSSRDVPYIANSLPHNVQECTKINLDMNSFVKEDVETFIRRRVNAWGWDAELRERAMESLLAKSDGIFLWASLAVKSLTYFRFGLDFDEFLRKPLSGLEDIYRTMLHTLFSCGGPGEVLNVIWGVALALRPLTFSELGYILACIEGEPGEQQPPHRMASSEIGPRTEKEIRMYVQSSMGFLRATDATISIVHHTATEYLFDKNRNDNLPVFSKSGADNMISWECFRYLHHVFGDPERFPSDGATRHHDWSQGTGLGQGQQQEELGEAPWEVARKDPQETAAKREFLRYAAESWFIHARRSIEISKDSSYNGSPCNWLRYQFFETSDAVRKPWVELCEDSRMEVLVGEQTPLHIAVCLGLMPLVEKALSEFTQGTNSYRSPLHLAAKFISGAYKILIDKSEPSLLTVADQDGNTPLHEAAISGHSSMLGVLVKLFAGNRAYSSEINKKNHSGNTPLHLAFQFDHVEIVELLVKEGADLTIKNNAQLTASQLGARLERADSLGILRRDENYWGGGSWRDGAPINSQVSATQSSSESIIRQDIHPQGADIAMTSLLVSSSNLHQPDPETHPPIPYDMTASEEVSRSHSNDAINSPDTGHYSSDTDYFDDDIVQKFEIAEERFEILAWLSPLEPRIKHRELRVRRANNIGEWLLRTDEFQRWCGGAEQDGSECATLFCCGGPAAGKTYFSSLVVDRLCDKAKEQNIAVACLYVEFTAREEQSPANILGSLLKQIVAGFERIPDEICRTFQDQKQVIGGRGPRVPEIVKMFQDVTSLKPTFICVDAVDECVESHRHEVLDSLRLILEKSSNTRMLLTGKRHIQVEIDRHLGTRAATLSIKPNNDDIVGYIRMRLSEDTYPGAMDSGLEEEIIKSITQNIPEAFLPISQKMDAILGEITAYNRRHKLRAVKEDVYSATLEWIKMQGGEKTRLGMAALMWVSHSERPLQLDELLRALAVEPGSTDLNPQRVPSVDTLLSCCLGLIVIDRDSSIVRLIDSTLQEYLYTKPDLFGPAHSVMAETCLTYLNFQAIKDISSTLSTLPQPTPFLEYSSLYWGVHAKRETSKEVASLALQLFSQIESHISTKLLLADLISRTDRYGSDIPINDLLAGFSGLHCASVFGITEVATSLMNQPNCDLSGRDFLGITPLIWAAICGHEGVVKLLLERPTVNPDKPDGYFRRTALSWAAKKGHEGIVKLLLGWATAKPDGTDGWWGKTPRVLNKVRGRRYVNPNWQDKYSQAPILLAAEEGHGGVVQLLLGRKDIKPDKPDSDGRTPLYCAALNAHEGVVKMLLEREDVNPNGPSGSRQTPLSCAAENGHEGVVKILVGRDDIDPDQPDEYGRTPLCCAALNAHEGVVKILLEREDINPNGPGGRRQTPLSCAAENGHEGVVKILVERDDIDPNTPGNYGRTPLWWTAWNGHEGVMRILLERDNINPDKPDEYGRTPLQGAIQRGNAGVVALLQPRGRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9C0</accession>
    <name>A0A2T7A9C0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="3 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="3 8"/>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9C0"/>
    <dbReference type="STRING" id="42251.A0A2T7A9C0"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="36"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU84315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="249" mass="28142" checksum="89A490F5D1A31505" modified="2018-07-18" version="1">MASEGSSGDSGSDGSGAEARARGGLLRVLNREELVYTGCYCEENIYCLVRDRISDDDQKHFTVAFISNSIKIIPLFYQKASKRPPLPVTWDYHVLLIHHPPSAPATIYDFDTTLSFPCPFAEYYTKTLYGPTSWEEYEGIIDPLQVQAYVANRPRSFRLVGASEYLRTFASTRKHMMNPEGAEGRWLADPPVYPPITCELGDDTLEMFLDFEAPNGSGWGRIVDEEEFWNEFAGEQDKIKVKEKGERGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9F1</accession>
    <name>A0A2T7A9F1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9F1"/>
    <dbReference type="OrthoDB" id="3946700at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="35428" checksum="1B7560CE221BBCA3" modified="2018-07-18" version="1">MGMPVWKEPVEKRDIDAVLDPRRAAVPRRSAHGRRIRSSQTLMNLLRDDFARETNTLSNITGGEGRRERPYPWSELSALPGPVPDPERAGLRVTLADAEARASSNTASGRGGIRRVRSPLPVFRNENNRLPSSASDTYTPRFPPAFPERQQEEELRRIRTHFSLPTAASSSSEGSGSSSSSNNTINSTALHRAGAEEGSQRPSQYLSRYESFIDEAESGRRDELSYLPGPSSRRWLEIDGLGDRERSLSPDPGHWELVANGLGFQTACDLWESDSDADGNPLASEMMWDPPQDREEAFRIRRLFSSRNGGIDRLVGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9F7</accession>
    <name>A0A2T7A9F7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_5030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9F7"/>
    <dbReference type="STRING" id="42251.A0A2T7A9F7"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF8">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="360"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="569"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="76291" checksum="9599447A87DBDD18" modified="2018-07-18" version="1">MSQCFPCRISSHNRKPIRILSFLAPAVPIDRTTIGVSRRHFSSRESPTFVPPSGRANCLLRVNTRKQHRPRIETGPGLRGFGIGLFRRNCSETEKLKESKSWSSGQAELGLRWRLMFSISRLFHNHSREQPRRFLRLVAAEGRDVEAIERVWRKLPEGDKFNFVSSVGTFLKEHSYWNMLNRFMQWYCMGARRPSGSLEICGYFNAIVAAKIPTGEAMEDIKVSRDERRRRADKLIAMLRCIICGNNFKGRPYIAQSVLYKLIFNASLDVLVGLYGELRKAKHQVGRYTTLHFVSRLSDLRTWDEAFSILNTFELGEGLDLMVAKAWHVFLKMFYQATYIGQEESNGVIQKMLACNIAPTTETYNILMSKAVREGNEDTMKEAFQEMLQAGFSPTMVTYGILHKHYKQVGKKEEQIMVIRDALMLDKRLNVILASDILHAKVLASASYAEVYTQFTRLFRPGALAALGLTSAARYPMLEKLEPNHYTISIMMYAFCREDRGLRVAWKMYREYQRVLREVANPHRAVLVRAGSFIPNSFMMAFGAHQVGLHYAASVMEEMLQERSPIKPGVVSWSILLQILVKRGDMAEAEQVIDLMASKGVQPNAVTWTTLLNGYMAKHNLYMTGQIIARMSQMYLQPDRATIDKLTAYLGSQELLGGIRSVEKPQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9L8</accession>
    <name>A0A2T7A9L8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9L8"/>
    <dbReference type="STRING" id="42251.A0A2T7A9L8"/>
    <dbReference type="OrthoDB" id="5403315at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049804">
        <property type="entry name" value="Choice_anch_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038133">
        <property type="entry name" value="choice_anch_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="TSP type-3 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754883" evidence="1">
        <location>
            <begin position="19"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="553" mass="54817" checksum="E38336D01AA3D705" modified="2018-07-18" version="1">MIFNIVTFAGLFATAVSGLAITPTGDANTLAQAILGSSPGIKLVSASYAGSPDSSGTYTDGPQGIRNAAVLTSGNAVDTIIGPGTDADISKSKGTAGSPLCSALAGGASSYDAAVLTMNVELLSGFTGFFTEFIFASEEYPEWVGSQFNDVMGIYVDGKQIAFDSTGAPITINGPFFMSDKVLVPPGSGSSFDGSTPILKSGHVAPTGAHKIEIAICDIADRLRDSSVFVTLGACTGECKEGTTVSPCAGKGGDSDGDGICDDVDNCPNVPNPDQNPAACALHGTGISGTGIKGTGTGGSGPSVTTPPKYGNTTVIGTATITPPCVTLTSMVTKTITTCTQKTICHPTVTVEPVTYTSTISLTVTTPCSTYTVSKCPGGPGSPCYTYTNTVTLAPVTTYSHTAVVTNTYKCPGGSHCPATVSSTSIATVHTCPGGTNCAVPSVSTITYKCPGGPNCPASIKTTYTCPGGPNCPVVTYPAGCPGGAHCPPVGTAPVPVTTSIAGCPGGPGCPPIYGSGNKTTPTVPQYTGAAGRVGAGAAGVVGAVGAFAVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9H8</accession>
    <name>A0A2T6Z9H8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1197733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000739">
        <property type="protein sequence ID" value="PUU72148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9H8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="299" mass="33819" checksum="2D0014CA83CB2D52" modified="2018-07-18" version="1">MFGILARAARLPIITRCLGLAKGPIKQRYRYSSTNGAGGPNQAPPNPPADTARMWERLGHVEVGFVNFLKEVCYRETGVCTEMASMMGDIKRLGWQQTAALTAFTGSFVYAAYTVNQVKRDLPNTIQPFRFQETPKDASPKLLQLHQDPQLSQSLPLQQRQQLHHLRQNLTRPKARTKDRQKKNQAAKTTPLNTTEKTAKTKKTKRTSNLTKPLTKNNYIRKEPPSLTQTKILTQQDKRHLASHLQDHQALTKSRLHPQVLHHYQAPDPPLCLSNQKAVAAPNGQHHSSIQEKEKTKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAS3</accession>
    <name>A0A2T6ZAS3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000498">
        <property type="protein sequence ID" value="PUU72597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAS3"/>
    <dbReference type="OrthoDB" id="4521797at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="102" mass="11252" checksum="8F6F6AFCC9664DBA" modified="2018-07-18" version="1">MAAGDYETLKEMYSQFWNNPTAAEYLVCETSQASPLTDDAYRAVDNLNSFGSHSCCQLNALQPQCSTLPIMGRLVLDSAEPIRLVYRVIWREVDVGCGRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBR9</accession>
    <name>A0A2T6ZBR9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1007144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000440">
        <property type="protein sequence ID" value="PUU72940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBR9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBR9"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="184" mass="21093" checksum="9673FCFDF7E7DCF2" modified="2018-07-18" version="1">MSSSEADKAAEKAAAEKEAAEQAALPYQWKQTIAEVDITVPVPQGTRARDLVVEIKSESLKVGLKGQEPILEGKFPKRTVLDESTWSLEDQKSVEIHLEKVNKMEWWAHVLTHHPQIDTSKIQPENSKLGDLDGETRAMVEKMMYDQRQKEMGKPTSDEEKKMEMLRKFQQQHPEMDFSNARME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBX1</accession>
    <name>A0A2T6ZBX1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1136126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000429">
        <property type="protein sequence ID" value="PUU72997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBX1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBX1"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01874">
        <property type="entry name" value="DNAREPAIRADA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="331"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="415" mass="43229" checksum="3FCD03C59D5BFD79" modified="2018-07-18" version="1">MASASPMPSSSHRLPTLSASQALSASQATDSRISTGSEELDKAIGGGLSRGKITELCGPPGSGKTTVGLQSAANALLSGDGNRVVWIDTSHPLPVSRLGAILSRSADPRELFPNLQTIRAPTLAHLLALVVHPLPTFPPEHTRLVVIDNVSTPFAAAFPPGMEDGGGGGGAKGKKEPVGVRRFAIIGDLISALGKLAGSKGVAVLLLNQMTTKVIPGVGAMLTPSVSEYIPPTVPPYNSHQYIVLITPTTDSPAWITSLNSRLLIHYNKTSLSLLANPDDTPVSQIRYVTILKSNGVLHGSDSSRPVVLLQIQETGVNDVKLVSEASPAAAAVKAYEPKRKKRKRGPEAGVIPGSDEEGGESEEDEEGSAGEMYQWEEGAEDDGMGAAIKSPALDSQNNQGFTKAGVNTAHQAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCC7</accession>
    <name>A0A2T6ZCC7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1164615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000409">
        <property type="protein sequence ID" value="PUU73148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCC7"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="62" mass="7458" checksum="8FCAF7A668AA3741" modified="2018-07-18" version="1" fragment="single">MLRDYFKFEVQFVPNVTDVDDKVGSFFPSDFRSRGKYMEWLRTEPSNLLDLWSMLYIKSTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD56</accession>
    <name>A0A2T6ZD56_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1135165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000377">
        <property type="protein sequence ID" value="PUU73428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD56"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="217" mass="24072" checksum="F5DD804FCC291B17" modified="2018-07-18" version="1">MLRFSKALPILISKPCTTAFHSGTHHGKKDGFPKPTSVEGEALTTLQAWQQYALSQQALSDKQLDKLTKALRDHQATFLEHHDKKEQQLQQEIARLNKALFDEKIRHSNRIEMLNPRGALEWIIEESQQQQKGVPSKKGVTSKKGAPREASRPRSDCKNQLSGYAHGVDPAVVVKTRNLGPDERAALIVLLKLQEKWSKPLSWREGGGGEGGGGVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD78</accession>
    <name>A0A2T6ZD78_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 70 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1004448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000376">
        <property type="protein sequence ID" value="PUU73442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD78"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD78"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="654" mass="71205" checksum="7D9DC85032D873E9" modified="2018-07-18" version="1">MAPAVGIDLGTTYSCVGVFRDDRIEIIANDQGNRTTPSFVAFTDTERLIGDSAKNQVAMNPHNTVFDAKRLIGRKFVEPEVQADMKHFPFKIIDKGGKPFIQVEFKGETKVFTPEEISSMVLTKMRETAESYLGGTVNNAVITVPAYFNDSQRQATKDSGLIAGLNVLRIINEPTAAAIAYGLDKKGQGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVNHFVQEFKRKHKKDLTSNARALRRLRTACERAKRTLSSSAQTSIEIDSLYEGIDFYTSITRARFEELCQDLFRSTMEPVERVLRDSKIDKSSVHEIVLVGGSTRIPKVQKLVSDFFNGKEPNKSINPDEAVAYGAAVQAAILSGDTSSKTQEILLLDVAPLSLGIETAGGVMTPLIKRNTTVPTKKSEVFSTFSDNQPGVLIQVFEGERARTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVEKGTGKTNRITITNDKGRLSKEEIERMLAEAEKYKEEDEAEASRIQAKNGLESYAYSLRNTLGDEKVEEKLDAGDKEKLKKAIDETVEWLDNNTTATKDEFESQQKELEGVANPIMMKFYQSQGGAPPGGMPGAGGFPGAGGFPGAGGAPSHGGGDDGPQVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDH2</accession>
    <name>A0A2T6ZDH2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nife hydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1094883</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000369">
        <property type="protein sequence ID" value="PUU73540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDH2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDH2"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="196"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="466" mass="52694" checksum="7D06D8BEBCBBB23E" modified="2018-07-18" version="1">MASTFARLASRSLTFTRPLAISTPIRATNALRPFTSTRISRAEAAPYQRTTLTELTPKNETTDDYLTEDPNHDPVQGRKMRHYTVNFGPQHPAAHGVLRLILELNGEEIIRADPHVGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMTNEQCFSLAVEKLLNIEIPDRAKWIRTLFGEITRILNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVHQDLPVGLLDDIYQWATQFGDRIDETEELLTDNRIWIARTKGVGVVSAADALNYSFTGVMLRGSGVPWDIRKSAPYDAYDQVDFDVPVGQAGDCYDRYLCRMEEFRQSLRIIHQCLNKMPPGPIRVEDYKISPPPRVAMKENMEALIHHFLLYTKGYAVPPGETYSAIEAPKGEMGVFVVSDGSERPYRCKIRAPGFAHLGSFDQVSRGHLLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDM3</accession>
    <name>A0A2T6ZDM3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1094954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000371">
        <property type="protein sequence ID" value="PUU73504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDM3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDM3"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="201"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="636" mass="68247" checksum="BCF6E5EB4FC20FBC" modified="2018-07-18" version="1">MGAVNINSSKNPRSPVSRTRPFPQFHRISIYYLAFLLLPLLILLLSLTKENIRSPPPPSFSHPLFSYLQTPELEIMRFHVLSLLGVGGALINVAYSAAIALAPRQTNSPEPIAPTTIPDFVDLLSLDSTTATEVAAKLNDSAAALNLTGAPPSKAKLRKRTADLATELACWIIQLKFAGDACQDGSTSYTTLSTLNWSKTCWLQPKCIVSPSSASQVSVAMIIVSYLNVKYSVRSGGHTPNPGYANSNGGVLIDMSKFQSMSLSTDGTVASIGPGLKWVDVYNYFNQRGTTVLGGRIPDVGVGGLLLGGGLSFFANKYGLACDNVKNFEMVTPDGRILNANAGQNSDLFWALKGGSGNFGIVTRFDMYARNDLAQIWYEVRVYDASQTPAILDAVENFQKNGEVADTKASFVFSATTDVTLVGYIYGGTASSLPSAFSAFSSIPFLGNFALPTVGTHYQLVASLASAFSPIPARHDYRAVSTGVNATMYKTVYAFWKTQALAINAATGGSANMSFSIQSFSKSAVDYGYSNGGNALGLVSQAQQWFTMLIDWDNAADDTAVRAAGKAVTDKWSEVSNALGFGNPYIYTNDASRDQNPLATYPAANIAQMRTVSHKYDPRQIAQNLQSDGYLLSKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDY0</accession>
    <name>A0A2T6ZDY0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000352">
        <property type="protein sequence ID" value="PUU73695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDY0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDY0"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10276" checksum="0894A619D5594A81" modified="2018-07-18" version="1">MLDGENRSMNNYIESGWFTFAVDGRVCIGRHLAMFMMKFTAAIIREFDIRVVKQPEEVHTLFNEMPGMEVLLSRRCDVCDRMRVKVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE84</accession>
    <name>A0A2T6ZE84_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE84"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015588564" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13761" checksum="A6E5E4EB50089F62" modified="2018-07-18" version="1">MTLTTIVLILVESLPLPPSLAAYIHGAHARWRRRISRFKGNRQFPREVKGREGKGREGGNVLLNCGLCPIISGPPVGKNLAGSPGRTDRVIAVTYKALPVSWPAQIKSLTTGRKLGYKSFTKCELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEN2</accession>
    <name>A0A2T6ZEN2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1-like dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_942053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000331">
        <property type="protein sequence ID" value="PUU73950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEN2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEN2"/>
    <dbReference type="OrthoDB" id="3001637at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1-like dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11368" checksum="1702278E4E46E398" modified="2018-07-18" version="1" fragment="single">GEVFVERPRKTVYAPTYFAIVAAWTTIVRVVIPKVIDGNLLKLPHLSISFRMLLGMHPFKKDDVVEIKAQISPILERASGKIVEVCEAISRDGPSTAESVGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF07</accession>
    <name>A0A2T6ZF07_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF07"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="53" mass="5868" checksum="49DB5431B8587C82" modified="2018-07-18" version="1">MRCSRLLTLPYCTFFIDSVSPFLTPSKPPLLSFEASYTKAPSVPPFCGTDSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF47</accession>
    <name>A0A2T6ZF47_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1001718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000322">
        <property type="protein sequence ID" value="PUU74121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF47"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF47"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19817" checksum="447AC7CD88AB037B" modified="2018-07-18" version="1">MINKLRPLDFKVLSLTTVATPHRGSAFADYCLKFIGKQRIPRVYKAMETIGMETGAFTQLTTGYMINEFNKKVPNDESVRYFSYGAMTQPSLFSMFRTPHRIILENEGPNDGLVSVSSAQWGVYKGTLVGPSHIDIINWGNRLKWIMPGLEAAGKRNQFNAIAFYLDIADMLAGEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF83</accession>
    <name>A0A2T6ZF83_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1001645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF83"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF83"/>
    <dbReference type="OrthoDB" id="5392605at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015638002" evidence="2">
        <location>
            <begin position="23"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="381" mass="41817" checksum="45FC85815FA2CA40" modified="2018-07-18" version="1">MGMSKATVSLFLSIFFATLVLCAIVLCTCAYCYKPSYLLRLQGRGRDYDLEKAPPGRIIGIDTEVGGGHPSGRPGAVFVEASDGEISDGETIEVLEAHPDGEQIDIIHAERPPTRSSQVNTFRPALFSGQHFFGPLFFLFPPSPNRYKMGLSQLRGFTIVITILALISNGLSASLFQQFSNKLYRSSNSLVFYSYFATFVSALGVLGSTKRHAYAMSIFANFFIIDTIISALSRSIIIYLFSTFRGYICDDNSATDGGLLSMTLPHGTFHQTSSDQPNEVSPSLWDGNWGCIESMRISVMVGWVSLAAATVIQFFFAILVRQYANSLFLKGHDDPERGTVCFGGPVREMDGFLVNQNGSPRRIRRASASSCTASRELEKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF87</accession>
    <name>A0A2T6ZF87_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_473996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000319">
        <property type="protein sequence ID" value="PUU74168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF87"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015545177" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10549" checksum="46790A9CB3C4FBF8" modified="2018-07-18" version="1">MRPAWIIPIWSLILRAVLKVRWHFCSSPLHEGLSQEYTAGVASQQGAQQPWLPFCFFCSVMGVGIPAPAHRLSRIFAGYDIGILLVVSNRLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGB1</accession>
    <name>A0A2T6ZGB1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1133220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGB1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGB1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018853">
        <property type="entry name" value="DUF2457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10446">
        <property type="entry name" value="DUF2457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="702" mass="77851" checksum="9EF09706514AFEF8" modified="2018-07-18" version="1">MPQRRHNSFTQQLLLQMQNLPTSNATNLPSSCDEELADEADEPPDSYSRKRRSFVSDGKFTKHAVHHQPNNISLLTRGLLINPGLEYTEPTEHIYSHSLKRGMSTDSTWSNPSTMELTSDGGMTSPSRANTPSPPPPMFLGGLAGLLHNEKDLLSKVPNTVEVVGESGIVEGLGRKRCITFACQDKPATSRRPVTPMKPSTPPKSETTADITPVKRSCALKFVCTQRRDTSDSHSSPQRPASGPRKLPSMEGCRNSQITVTNTATETTPKGTTTAPASMAIQPSVFPDKFYEFASSVDDKSDSWTHQPFDKSRLLKVDDLLKKELDIRKLSREAEEEALQEEEEEQDLEDADGDEDEDEVESVDGDDEDDDEDQDYDYEEEDDALSGNESDNEAGFASDSDDDDDPFFTYGPMLPITGAIGRPVCCRTESTSSIESLRRLQTRPSLRRPRTPDLPDSTDFVCGTLDEDKPLEEAYLSCIEERKRSRHIITPQDIDPSFPSDPENSDDEGNINLSESEDGFHFAKPIWSGSSFEGARKRGRRRNDTITKKVLGASPKGKARAHSPAPLRRINASPRPVARRTMSPPPFNRAKHRSQMFQPRPGIFHTKSLPRTPSFFGRKAGRTHSASTSPKTSAISPVVRRGAIDIVKGLEKKRERRKARLCKAREGVDCRAGQGVEKMRELGLEICGKGKGRTKAQWVLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGP3</accession>
    <name>A0A2T6ZGP3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_422854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000286">
        <property type="protein sequence ID" value="PUU74626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGP3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGP3"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048379">
        <property type="entry name" value="Rad26-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022093">
        <property type="entry name" value="Rad26-like_helical"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21046">
        <property type="entry name" value="Rad26-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12331">
        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26-like helical repeats" evidence="1">
        <location>
            <begin position="29"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like C-terminal" evidence="2">
        <location>
            <begin position="245"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="298" mass="33255" checksum="920766BF0850CCF9" modified="2018-07-18" version="1">MFLLDLLQFSVDWDQGGKCHWFCEEVVGLIQRTVDINAIPTFQKNLSKIEKDVDVTSCLELLESIALGMVGNEIHVRRFWHSVRSDFPLILLNPAQPIEHIRRMASILCTSVTSQSFGPRGSNEAAQRQNESNLLASITRVLADTPGSTTGEPRWDKVEAVELRKEIVQFLGTIAGTKLGIEALAQHPNALLRLSKRIAEELEEVYEWKYGADESSQFLNSAVRLLHAIITTNAQEATVKLSGSASHKNLASMTRIAFSDGVLQESGLEETVIELAHEILEVMVTPHEGENLWDIFHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI45</accession>
    <name>A0A2T6ZI45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1110251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000249">
        <property type="protein sequence ID" value="PUU75142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI45"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015737738" evidence="2">
        <location>
            <begin position="22"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="153" mass="17135" checksum="24137CD486128216" modified="2018-07-18" version="1">MRFIFSAIPLLLSFSFPQALSAPIPQISQCKDPLGFLGCLPECENPFNPSDLCVVECAKAHCEADPLPDPPTEEPPTEPPVTPPTLKQRGLQYIHDSTREKTLEGCRDPERYPSGKSQIMRQAAGHIFPKHYPRITESRRATDPRKALPRGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI49</accession>
    <name>A0A2T6ZI49_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1195697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000247">
        <property type="protein sequence ID" value="PUU75170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI49"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI49"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="531" mass="61217" checksum="7C5868293F8BE3DA" modified="2018-07-18" version="1">MFLNLFGQALYGFVQHKLYLVTGIIILTLAYWIHSYLKSPFRAQKIPGPFLGKFTNAYRWYYTMRHTWHRDLMALHKKYGHIVWIAPNEISVSDPNLRNVIYGFQNHKRDFTFFKKARSYEIGSINHDFSFVFEQDAGNARLGKYHMSHFYSEQGLLDLEENFDKAVDELIEGLDKHHVKTGTPCKMVDWTEFFALDIVAQITADQSAGFCLAGKDADNTAYGVRVILRAIGILMQLPWVLSVTSRTIRGNIFLNYLTTLYRNLLLLPTFTFETGTADLKTLKEKSPKHLLSKFYNTQSKMRGHYPQGNEAEGTTIHIFNLIAGALGVVPHTQVRVIHELSRHPEYMQKIREELSKTDNTFRLDDFLPYNGGENKYPIFESAVRETIRLHPAVSFSLSREVPPSGCQLHQYHIPPGYNVGMASYQVNYDEAYFGPDVAQFRPERWLEDHPTAMLDGEKRSMKNYIEAGWFTFGAGGRVCIGRHLAMFMMMKFTAAIIREFDIRVVKEPEEVHTLFNEMPGMEVLLSRRCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI64</accession>
    <name>A0A2T6ZI64_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_367219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI64"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="355" mass="39931" checksum="4E43DFDBBF33850D" modified="2018-07-18" version="1">MPSTLYSLIEGRDLAPKRIDDPVAAGLTDWFGKYLVEHENSQYPITFRSLLEDTIPHKTWVPFAVGDGTYLKYNPENNDIPRDLRFVVVATPTSPSTTNPQGWPKDAIVADVNHVQSEAFKKNIPTLFIVGSTVFDSETIFLQIASWEPTSGNLNFYQRDIKFSEKSSEYPSWLYLGSSSDAFEPDTRGKGPFDGHVNGTLVMKELNTPWVHWNSMKFNFSQMLPPDSPLRTEPLLNPSNNLNSFDFLAGAERLELIVKKAADKWFTVRERKDFGPIGAPTPTITHVRDWIQHILDTTTINISAAGVNSEVVIADEGDFWTPQGMFYDSQSLEDVVQSLGTTGFDVYTHIGQRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIA4</accession>
    <name>A0A2T6ZIA4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1103082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIA4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIA4"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="265"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="662" mass="74022" checksum="595969766C51B1C0" modified="2018-07-18" version="1">MNEGAEICVLCNFHSQECTFVQSPQPRKRRLASSNVSSEDQVVIKKRSTEPESPQETAIRGNIPVDDYANLRGPSLLKTTLGLQGHRHSQLIGPTSEYEPCLIDLCPFDQKDEYMLSSAGGSFRRASDEITFLMFPDHPTQNHSEIFDDLDAIERIVAPHGQSLINLYFRIVHPSFPILHKKVFLEKYSRTHREFSPPLLAAVYILALHWWSYDRDLSPQKKPDVAALEKLASKTIADVMHRPKLAAVQAGLLLLQRHSDLKGGSWALTCQLVAVGQELGLHLNCEGWKIPPWERGLRKRLAWGLFMQDKWGALTHGRPSHITRSNWAVPAVTAEDFPENAADEDDEEGSSEVEKGRMLFEQMINLSGIMADVLETFFTLEAQQSLAGRGGINRVLEKAKPIQIRLKEWFSKLPECLRMDATKVRKLSSNGYLHLSYFATEITLHRQILRSLSPPTNTESYIHHICRSAAKTRLISAMDFVNRLKPEHLQSFWYFASKVNFALIGTFGSLLWATSPNTQEAEFYKARLSEYRWTLRVSSRGAEFMEYAVGVLDASAGEVDDDGEMTDGSSTSSRRRLNSSSASPSMKAYQGFPFVDSGPNDPLATNASTPTSTTSSAFDFFMIPNGMPGGRMQGAEAAGVTRGELDFLAATAGWRSRRDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIK0</accession>
    <name>A0A2T6ZIK0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1103008</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIK0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIK0"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="6">
        <location>
            <begin position="153"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="244"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="623" mass="69199" checksum="F8FB0830AB55E7D3" modified="2018-07-18" version="1">MTPRAERAAARKRSQPSSPASNKNSPKKVKRDSDDHVDEVDESAIVEDQEPEESPDSPLQPQGDITITRTPASSPPPQDTQVASQFYYPPLAEQGVDEDDETVWGYLWPLTQKNQSVIKLNKTPQVSTPNKGSPGSAEKKKPKNNKKHGAGGFVIGRHVECDLVIDHNVISNRHCVIYKENAGSQPVAVLEDLSSNGTWVAGVIIGRNRSRTLENGDEIEFPGGFQYTFRYPPHMQSSAFRNAYDLGQQLGSGHFATVHLAVDKKSGQEFAVKIFRKRRNEDKSKTSGLQQEIAVLMSVNHPNILCLQGTYDEDDGVYLVLELAREGELFNYIIRNTKLSEMDTRKVFIQLFNGLKYLHERNIVHRDIKPENILLCDTDLTVKLADFGLAKIIGEDSFTTSLCGTPSYVAPEILEPSRNRKYTRAVDMWSLGVVLYICLCGFPPFSDELCTQDNPYNLSQQIREAKYDFPSPYWDDIADPALYLIESMLEVNPNKRVTVDMALRHAWTVEGTFNPAESCDSLVGALETMGLRRSVGRERTLLAEHPEIRPTRAVETAAVVSPVTSPSVVPESEGGAEEVVTRETEVRDGNPSDIPAVMTAFMHVGGRGGDETLYPDDSFAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIX2</accession>
    <name>A0A2T6ZIX2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1067431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIX2"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30973" checksum="66347004E312BDE3" modified="2018-07-18" version="1">MLLTETIQELYTPSETDATSIFEESLPTVFSDPRVQHGEPGEYLLYKNEELGDFKLKLATPDPSNTSLFSHYIWNASEDITNASTNVPTAPENITNAEFNVAGKKVLEVGAGVGLPGIIAVYCEAEETVISDYPAKEILDNIQTNLEINLSRSQLAKVSVIGHEWGQTDDKLCTSRPGAFDKIIAADCFWMDSQHENLAKSVKALLARDGELLAFAGFHTGRAKVAGFFDAAERAGLVSVKITEKDIEGVEREWVRDRGQEDPVERKRWLAIGVFKHKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ36</accession>
    <name>A0A2T6ZJ36_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_338976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ36"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="12370" checksum="D2476DBBCF0AE8C4" modified="2018-07-18" version="1">MLFSEKWLFFLWWRAKQGLYAFYLSIFRSGRGKEEKEEKKLYKEEKKKRTCKNLQKENNKTIRETRTSNNKLKFHPHEPNSMEPYKQKLIYPHPAMRENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ57</accession>
    <name>A0A2T6ZJ57_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase S24/S26A/S26B/S26C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_994266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ57"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ57"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="19286" checksum="29E9F7802F6A8183" modified="2018-07-18" version="1">MATLFRRLTSTPFLRAQLQTLTRVGQTFFFIHLFWEHFYCVGAATGASMLPTINIAGDWIVISKLYSRGRGVGVGDMVSYVRPVDGPGVHVSKRIIGMPGDWVVVDPEKGDEVIKVSVGRVPPGHCWTTGDNLPFSNDSRHYGPVPLALVRGKVIARFKPMPKFFENGLKDVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJA1</accession>
    <name>A0A2T6ZJA1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1090076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJA1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJA1"/>
    <dbReference type="OrthoDB" id="5572782at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015500036" description="Fibronectin type-III domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="947"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1047" mass="112813" checksum="1AFAAE1FF647877B" modified="2018-07-18" version="1">MGFVILATLTALLWMCYRASSLFKIPIPALVKLLGLDLPDPPRVSLHGIAADTITLHWSLPEKAGSVAKHIIQINGINVGESEKRGETSVTVTGLNADHLYNVRVIAANSQNFQAPGQLIRLRTRRGSQTASEGAPLAAGRDPSDDLPAVHALPPALEPQPPHNHHHHSASNNNNSNGNNGAGNHRRTGKGGKTSPASLGQQGQAGSAAEEQHSVGSLTASLEIVRQEIAETDAQLVHTEEEFKAAEAVLRAELDLLKEKKNEEDLGRQKLRAETRALEEGKRASEAARSKTEKALKNKEDEIKKMRNDSLRWDEERIAALQRVKELSKAAEESREHAQITERELQEEMKETQKAILEMEEEIRAHVGNIKALEAQREQWKAEEEAERKRVAEDEQNEIMWKERQRHLEVRYITVYNAYQVAEFDYMRSREALLNSQSRRGSAGTDPIAPPAKKAKQRRNRNRKSRTQTISSPTGIVAPQDARFPDVSAGSMSISQMNVPFSSGINPSPFFNTANGTVGAPAESPGPAPKASFSVDLDRISGGAPMSPTANSLLPSNLFAFEDSPPSPKGSASLLEDGQSRHSGVDPLGFMAPQSPISSGSVSTSHVSSPRSSFHHIPMFPNVSSDGDPGERGNSISLIGSGLGQLGSSEEEESVSGGRRFVKLLSGGFNRQRGKTIPLDGGPLLGSLKPNESHSFPKSPHPPGLDPIGTRRRSGSYGGWATGLEFLHGGRKKPLERTDSSSSRRSGFNHFSPSFDPIEPGKLFDTTVSARPSSITSFDNLLPAPSSDVSAAFGWPAAPPAIEQPRNRVSLLGGRWSDFASSRPNPSRPVSRPTSPDANTTTNLSLSHLPYQSTRPVTPRLNPAAPTFEAPAALKEENASSAISINTDTSNTSNVSETPKDSLLSRFSALSKKGSTSKFNISSAWKKDGGFFSRKSKDSDVEDGEEGPITSTTSTPLIGSGGGIGGVSPLPWKDKSGFFGRGKRNEDDEEEELKSGSGSGSGFFGTIGRRKADKEDESGAVGEKEKEKKEGLGIFGRKKEKESGDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJR3</accession>
    <name>A0A2T6ZJR3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJR3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015700501" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10185" checksum="3823F11DFFA8CCF4" modified="2018-07-18" version="1">MRNGEMGVLGLLVVSKCLATTREDHEVPRNFFASFHSSKKMLVTEGFLISHYITNRRPFCLALIYSKPEPVRQMILVMIHENNMTTESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKQ5</accession>
    <name>A0A2T6ZKQ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000204">
        <property type="protein sequence ID" value="PUU76077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKQ5"/>
    <dbReference type="OrthoDB" id="5371018at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="18191" checksum="94E4569FE86ECFA5" modified="2018-07-18" version="1">MANSKDQILKRLGISEGVYSQIREFLRKNVDWTAFAGGYEGFTALPEENLANLKHHLVKKFPALDGKDEEIVWIIKRRYRNHQTIKKRKEKRAITSRSCYHSPSPSRSPTSSNGDRKLDQENICSLRDESRTIHHVEPHLDKGRALSVASIHYLLNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL42</accession>
    <name>A0A2T6ZL42_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000196">
        <property type="protein sequence ID" value="PUU76217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL42"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL42"/>
    <dbReference type="OrthoDB" id="5409589at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="507" mass="56267" checksum="7B3271E54698DAC1" modified="2018-07-18" version="1">MAFLLPSGGRPSLTPLSMFYPRQTTSSENPWAPPTSSRLSPYSTSLPPLETSVTITNSHYYRPPRSGLTSLARSTISSSTRSPTRASRQFQVQSLLATDPLLCHLTPGKIVRLSTSGDVNFEPGEKEWSLRAAEGTVNVNEWLREVEGWNHEWRRTYRESKDVGDGYLPPIDRPENRRKLGMGSIREEEEGAMLDGSKPVRRRLFSEDNGTDGSGGVIVKDDRPEAVAVEAPKPQTDSPGLKRDGKPLTPYQLRMQRQRAAEVGNSGRSELDQILVKPVEKIGVTEGSEEENEDEDDELEEGVEYWGSLKRSKVEGFKARIEVIKSEIGELDVDGLKHRVLLYSASAADLLTDSAAIMTVTTLQLLPPLSRLTKLLEVWAVRISVLGIVPVFLRSLQIAKDTLEAGYKAITLPSINPESGSLHGGWSGLAEESYTIMQETITQKVATAGMLMDTMLDALEGREDVLPEMWIAELEDVEEGVARWEMDGERVVLEGRLRLEETKPRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL53</accession>
    <name>A0A2T6ZL53_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1088720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000196">
        <property type="protein sequence ID" value="PUU76215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL53"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="12276" checksum="EE0C1F3B844E9F31" modified="2018-07-18" version="1">MTVPRLYLPAPVATIPSPLRHIRPTNPPNDPNQVPCPELRSSWYDSREHPPPVPIRNQCNERELHRPPVLYLTDSNSFHPITQLGLANCSRQEVCDNPCWMDSQARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLS2</accession>
    <name>A0A2T6ZLS2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Common component for nitrate reductase and xanthine dehydrogenase protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnxH</name>
        <name evidence="6" type="ORF">B9Z19DRAFT_1149488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLS2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLS2"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000003">
        <property type="entry name" value="Molybdopterin converting factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="21755" checksum="E50B06EA25814BEC" modified="2018-07-18" version="1">MSEQAHEEREAENGQVPQQQQDQQLDFLSRENIHVELTSAPLCITKVMNRIRSPKAGALVLFAGTTRDTFDDKPVAHLSYTAYTSRALATMMSISEEILLKHGLLAICIVHRVGEVPIGEESVLIAVAGKHRREAWHGGEEALERVKERVEVWKMERFVDGEGVWRSNRDGGVGVAVDGGGDEDGGDGGVKGGVEVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLW3</accession>
    <name>A0A2T6ZLW3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Adenylate kinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_249938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLW3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLW3"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="6">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="22688" checksum="6CFD4A62884C52B4" modified="2018-07-18" version="1">MLRSQVAKKTALGRAAKKIMDEGGLVSDEIMVGMIKNELDNNTQCKNGFILDGFPRTVPQADRLDSMLAHRGEKLDHVVQLEIDDALLVARITGRLVHPASGRSYHRIFNPPKESMKDDVTGEPLIQRSDDNAETLKKRLVTYHQQTKPVVEYYKEKNIWKGIDASQEPGVVWRQLLGVFGEKKQSPVSAAGSKILEKVGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMY5</accession>
    <name>A0A2T6ZMY5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1087474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="NESQ01000172">
        <property type="protein sequence ID" value="PUU76858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMY5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMY5"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="28712" checksum="40DCEF61DC5CC987" modified="2018-07-18" version="1">MTKQPSLYAFPDNPTLQQNLYHYILQAQADALTRHQKFKIAVSGGSLPKLLASPDLLASSDIHWDKWEIFFADERAVPLTHPDSNYALLEQEFLSKIPKTAPQPTVYPINPEKLSDTEDLADAYEQSLIASFAAKDSVKLPIFDLVLLGCGPDGHTCSLFPGHVLLREEVAWVAAIEDSPKPPPRRITLTLPVVTHALKIAFVATGAGKKEVLRRIFDTQPETEGGEVLPCALVNLGAGEKVSWFCDHAAVEGVSFSKKSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP01</accession>
    <name>A0A2T6ZP01_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP01"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="13941" checksum="49956F91A616AAEB" modified="2018-07-18" version="1">MITVSTWVDMIIEIFAKGTFTKLHFKIGSIALDLGVVFLRQIIRARRLGRKSTDGAQRYFSGEDFTPAWSRELEFEQTSNDLLIACGFFFSSLSFLYFFYFLAPGRLGFFPFVPWSSGCSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ22</accession>
    <name>A0A2T6ZQ22_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1085906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ22"/>
    <dbReference type="OrthoDB" id="5414969at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="32325" checksum="330EA621EAD0C198" modified="2018-07-18" version="1">MSDDLLSHHHLISYPSFIPLSNNPTWYTTQLPQNRSKNRTYLFLPTPTSVSSFKHRIQKFLAINPNWSIYSFDRSILEWYTKATRTSQLYEMRMGSGSRRVGYTGGENGIGRVVEDGEWFRETHNDEATLVDEEDVLSVIDSVGQRLAFATCLGDAGRLLVTKIEVAEGVKQSVRGVEVVRMLLGTVADIAERGGLRVWINIPVEDAITVGVLFEMGFVVNRMLWLVEGDAEVKDESGVADIVVGSGRVKSIVEKNKVEVWKLPDWEGGMSGWREQWSAALDRIMAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQS3</accession>
    <name>A0A2T6ZQS3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1101660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQS3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQS3"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011270">
        <property type="entry name" value="Pur_Nuc_Pase_Ino/Guo-sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01700">
        <property type="entry name" value="PNPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU77839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="315" mass="34211" checksum="FD60907AF4AA822C" modified="2018-07-18" version="1">MSESIYTQATESTNHIRNLLPEQLKNPHVGIVCGSGLGGLAGMLDQELLFELSYEDIPHFPHSTVVGHAGKFVFGFLGERKTPVVVMVGRVHYFEGHSIQKVTFPTRVMKLLGIHTIIVTNAAGGLNTEFAVGDIVVLNDHINFPGLAGQHPLRGPNEEEFGIRFPTLSEAYDLPLRKQIHLSYKKLRLTSEKRKLHEGVYVFVSGPTSSFETRAECRFLRALGADVVGMSTVPEIIVARHCGIRVLAMSLVTNSAVLEPGPRGDSLLVAETDEEGLKCALEAGAASHEEVLETGAAAAKDLQGLVRQFIDDIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRD3</accession>
    <name>A0A2T6ZRD3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1084897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRD3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRD3"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="282" mass="32060" checksum="85BBF6CDF49136A9" modified="2018-07-18" version="1">MDQTSDASIMEAVTRKESRLERVRKHFPYWIMPLICAGVWFSTLWAMMITWLAQGQPAYASFNRGQTIAYISDIGANVLKPLFITGCAITAVGFVFSLAFMRRNHALRSRLESTMDWLALASGSFGAASLILLAVFDTQRHPSLHRLFLALFMLGVVFSAIFTTVEYWRLGKTFIEHPILRKSYWIKTGIIIIEVALSVAFGTTMAAHKANVAAVLEWLIAFFFTFYVISFFYDLRPKARTKEEIQREAKSEMRSISFDQGLNPYREYQGQANNNTSGVPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRM8</accession>
    <name>A0A2T6ZRM8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1108428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRM8"/>
    <dbReference type="OrthoDB" id="3358048at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="210" mass="23860" checksum="08A00EB0652CEDFD" modified="2018-07-18" version="1">MSGTGASSGSLNTGALASHLNFPGLDRINIRKRLALQDQQENDPDEVVYMDEEEQDRLIQQLKYEDSGKNDFFTKLIFVLEIAQLPMFFFRLWTVPNWTDLFSIVSMITSALCVPTTQGFEDRSELAPEPRWVPGAIRLNLILSVMIAMATLLKHYIPPEGVEVTFHMDAYENMGLIPLVLWVFTQVTRKALRAVDTGSLEELRYRYLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRZ3</accession>
    <name>A0A2T6ZRZ3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1127047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRZ3"/>
    <dbReference type="OrthoDB" id="5342846at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26482" checksum="2B6CFB6B3ED1AFB1" modified="2018-07-18" version="1">MPASLCPSGDSRWTGLGIFPVRLMLFVFIIAAISVSAVEIVATININAITALVLGLITLVHTIVDIALFFNSKLKPVYVVAMSSIMFSFWLSFSVWEVVEMVYMGHDRRSGSYYGSYQCSIVDMKDYHSNSPGDWSCPLPKARFSFSWILVLLYIASIVYSAQALKKEKKDTFQRQVDQAVAAMQAIRPPIMGCPQCGVQMLAHQFFTELPSPQYVQGNPAADSEKVNNDPAKNYIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS43</accession>
    <name>A0A2T6ZS43_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000123">
        <property type="protein sequence ID" value="PUU78312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS43"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="21060" checksum="00F72B506B8CFCB0" modified="2018-07-18" version="1">MAPQSILKRESLCRVCLDIWKALTLKPDSGSVRHAITEPLMTTLYAIPSVNCQRDIPIRVFSMVLLSLLKGESLCWVLLDIWKALTLKPDSGSFMNAIMKPLNKSVLHHPIYPPSKGRPHTNSGSVRHAITEPFNDGSPRHPICQPPKWGPHTSIFHGTTKSSEGGVLMPDFFGCLESTEFNARFWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS94</accession>
    <name>A0A2T6ZS94_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS94"/>
    <dbReference type="OrthoDB" id="5412028at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="398" mass="43906" checksum="30AD75F681D5A182" modified="2018-07-18" version="1">MSMSTNPRFTKHAKVNENNSAAIKLVPRGFTVLIDNRNTGYAPTKEVTMPPCTPHPAFSEKLKEPKKDEYDVPYDEDFDAWFTRWEAKEAQRIIDGAPIKYNEHGQEIDEDLEAYFDRIQMDISSGLYKRNTKRHLGLTDREEPGLVERKRRCLPPPPLLKPDTTDEIPKDTKHIVPAEPEKFRAPMQGNAATATVYQGLCDKTDREQNIRVEVKETAPKAMNAKNASPGVPYAGDDNTATKPPSDVAPTLSIGQSISKPPGWPESLPAPPTSKAWNGRRSSPPVQGPISNSNGEEPSAFCESETPSAIEYYQGIETYIQTDTPYAPGPMTNFHGDPNIISPGNKRGSNSLDGQKGRISSGFYEPGGQGSRKGNGGHAGYRGGRKGRKNRGHGHQRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSB9</accession>
    <name>A0A2T6ZSB9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1084274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSB9"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="36895" checksum="50026937A5C7289D" modified="2018-07-18" version="1">MLLDLPLDPAAKNSHGKIPLHYAVSGKNESAIQVLLKIYLKELPATSAFPELPQKKRLLFENWCASEAKAALFYSLRPTPHQSIDTLKTALRWAESKNNRTIASLIVDNIFQLIPNDPDPTYVFSALLHWAAEEGLELVLKVLLEKGEPKVDKFGSTLLHKASFAGHSAIVGFLLGKFTDPQVRSAALFIASWRGYESIVNLLLDIGVDLESKNEDGQTALHWAVIASDMKSALQTLNAPGTRKRPKNKTVNIGMVKLLIDRGAKVNERNSVEQTPLHWAVVRGDLKAIELLLENGADLKAKDDEGADVIEWAANYSETDEVYRLVKSWEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSL9</accession>
    <name>A0A2T6ZSL9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1101343</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZSL9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000973">
        <property type="entry name" value="Multidrug resistance-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="932"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1160"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="310"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="652"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="943"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1230"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU78485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1493" mass="165870" checksum="6C2D2020CB743F23" modified="2018-07-18" version="1">MDPFFSTQTSSSLSRQHHFSSPASVDFNTWGLGSATRLGAYGVTIVLAVSFLLLRRFLSGDPFFPPADRRSYNIVNRKLFLELYDADELPKAPIEELRGTRLRLAWIQALCFGGLVSVDAALLILRYLRGEMIIDEVAELVYWIFLSALFLYRFYPNPYRPTLHTLTSVGILVPLLLIVERDILPKLLLHPSRERLFDVRTGWAVYARLGLTLAIGILSLATPRVWYPVDPSAGGEPTPEQIASPFSYAISYYWIESIIHVAYRRDVEVEDLLQVPDYDRGKLWGKMIANHQRSTTFRTLLSLMKYELSLMTLFSFLLGATQFIWPLSMKHLLAYIEGSSQPIVTPWTFVMGMFFGPLLCSVAWEAYVFQSNRVGVRVKAALTQSLLDKTLKIRFTADSVSKEEKRGVTKKDKGKENEAESEEDHKKSRVGRINNLLSSDLAQLSSARKLLLIYFYSEFFLVFGSVPVEILLSVVFLYGLLGWSSLVGVAMMIVTMIIPGMLAKLLAKVERRTRLASDARIEAMTETLNSVRIIKFFGMEKVFLSRIREKRENELWLSFLSMIYSLGFYTVSHLLPIINMVVTFGIYTEVMKLPLTPSLAPLKLTWVSHVTRSLISAFVSFDRLDKFLIEEEELERAEQVEDTAKREIGPYLKNATLSWSMPGSGTDDGFRLADIDVECVYGGLTVIAGPVGSGKSSLLLGLLEEMRLLNGERFLPRGDGVAYVAQTAWLQSLTIKDNILFGSPYEEKRYNAVLGACGLSQDIEKLDAGDLTQVGEQGVTLSGGQKARLALARAVYSPAQTVLLDDVLSALDAGTSKLVFEKCIKGEVLAGRTVVLVTHHVSLVSSAAKKIIVLANGRVVSDSSPETLSDDAIELLRETEEADVASNVAPGEPAEQSIEAIVPEVKPKNSGKLIDEEARNKGRVPKKLVFEYLKYFGPLMVTVVLVLISMLSKVSDLIDTFYIGLWSDQYSKPGPVDVKCRSLLVGTSIFNSLVWCIWYFFSWVGARRIHEKLVSAVLYSPIRFFDTTPVGRIINRFSNDIAVLDDSLGQYVSVVFDQLLDILFRAGVMVGLLPAFLVPTILVSLIGVTCGELYVRAQVGVKRIISVKESPLISHFGDTISGIVTIRAFSCQERFREENIKKIDDFTQPNEANYNLNRWIGIRTSVCTSIIGAAAGIIALTTKGSSPGMIGFSMSNALAFSSSILYAVRYFNLLEVELNSFERVKEYIEMKQEPSSRPEAEPPAAWPTQGDLKVTELSVKVGIVGRTGAGKSSLALSLLRFTEISNGSIVINGLDVQKINLEALRQRITIIPQDPVLFSGTIRTNLDPFGGLDDTELQAALDGSGLAEAEPSAALNNKQIGLDTQITSGGGNLSQGQRQLLAFARALIRRSKLVIFDEVSSHHAYEPLKRDERIQETIRTSFPDSTLITIAHRLRTVMSFDRIIVLDNLGNGGEIVEFDTPFNLLQNPEGMLYNLARKSGEFEELLKLAEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSR6</accession>
    <name>A0A2T6ZSR6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1083910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSR6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSR6"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="247" mass="27096" checksum="115AF2D045B5D9CB" modified="2018-07-18" version="1">MSGSAGFDRHITIFSDQGRLYQVEYAFKAITAANITSIGIRGKDCAVVISQKKVPDKLLDPSSVTYIFQLSPSVGCVMTGSIADARAAVSRARGEAAEFRYKYGYEMPCDVLSKRLANINQVYTQRAYMRPFGVSMTLISVDDEMGPQLYKTDPAGYYVGYKATSSGPKQQEALNHLEKKLKNKDYTPGDWKEVVETGISALSSVLSVDFKSGEVEVGVVGADGKPGFRKLTQEEIEERLQSIADKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT35</accession>
    <name>A0A2T6ZT35_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1064883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000113">
        <property type="protein sequence ID" value="PUU78623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT35"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT35"/>
    <dbReference type="OrthoDB" id="5413892at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="236" mass="26292" checksum="AD706E062D0EEDAF" modified="2018-07-18" version="1">MAHIKEEPGAQTHPQLQAPRPALSTQLYSPTSRPPTLIMAHIKEEPEAQTYPQPDSQIAAQGSQNTTTQTTRTKKAPTDPILAMLHQMEETMAAIQRGMEAQLEEQTFFLKQADHLNQQADDLIQEAKRMDMCEQIVDTRSQTLLPRTLDDISPRERNSIARLFNRGANRDNTVLKSLYGVNGQLIPGFPRTLGHAKRLNSEALNPLLLALGLPVSGSVAVRKTRFFNYVGLVYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTI0</accession>
    <name>A0A2T6ZTI0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Piwi domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTI0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTI0"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="73"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="19380" checksum="76D4A1AF316CF8F6" modified="2018-07-18" version="1">MTTPRPGISNISKTSVEFCSPKELLSKDKEPVSVDQTAISSNVGFDKINFVLADSSIQQHVYRLEDKASEFVQRHHNRFFPLDKGDKNGNIAVGTMVENGHGKDIFMVSHAGLQGTVHPTHYMMLHDENILTAVDFQRICNNVCYAYGRATVSVSIAPPVYHANLAAIALALMSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTT7</accession>
    <name>A0A2T6ZTT7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1047641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTT7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTT7"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="9">
        <location>
            <begin position="248"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="465"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU78901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="705" mass="77916" checksum="EC0DA09CCA491B96" modified="2018-07-18" version="1">MPGFETSQAQTYPFDTVPSQERRRSISSATQEAGWAGIPLVPLYIGAAATEVDAKTVRIGISIHDGVYSVDTCINQVAAKDGEHLEDLIRKEAIKTIMLYSVQHNAKFVGAGVTLDLERICPGICACLWRELDIVGMKLKVQTETVGAFEDTGTVPVDVDEQADSAARKCVMYFGPNHNPALAIAFRNRVGPDAQGAIRLVEGLGEYEATVHKGTWNTVLKYAYELRGYKAGRTEGGLQRPPTKIASFSATPQGGGVALMRHALVRFCTELGVDLEWYIPKPNPKAFRITKTNHNILQGVADPEARFDEDKQNLLNEWIGTNAKRYWLTSGGPLAPGGADVIIIDDPQMPALIPIIKKVRPEAKIIYRSHIEVRSDLVDRPGSPQEQVWRWMWNYIKQADVFISHPVDKFVPHDVPLEMVGLMPACTDWLDGLNKPLREWDLRFYHHDLRNSCNELGMNQLLYPAREYITQIARFDPSKGIPDVIESYRKLCARVIQDTPEKLPPQLLLCGHGAIDDPDASIVFAETMELLAQPRYSAIAKDVVVMRIGPSDQMLNALMTTAKLVVQLSLREGFEVKVSEALHHGKPVVATRAGGIPLQIQHGKSGFLVDVGDTDAVANHLFDLYTDDDLYAKMSDYAKASVSDEVGTVGNAACWLYLAAKLARGQVLKPNARWITDMAMEEAGQRHELGEPVLPRGGIDIKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU22</accession>
    <name>A0A2T6ZU22_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1064666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU22"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="10955" checksum="ABF91B1BB97722EA" modified="2018-07-18" version="1">MAAPPPVLSPLSIRSLFPLLTRLSPTSPTANRPTLLTPLQIASAQSSTIEELVRSRSWYIILSPSCGLASRIVSKVISGIAGQALGIPIRVCVFGRMMEVGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU27</accession>
    <name>A0A2T6ZU27_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1192947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU27"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="40065" checksum="109BD9024956435E" modified="2018-07-18" version="1">MPDSGGVRYAIVEPFYDGVLRHPLCPPPKGHPHTSIFHGATESSEGGIPGALGMRSWSPFMTAFYTIQAIPGALGMRSRSPFTTSFYAIPSVHHQKDIPIRAFSMALQSLLEGEFICRVLLDVWKALTLKPNSGGVRHAIMKPFDDGVLRHPICPPPKGRLHTSIFHGATESSEGGSLCRVFLVLGVYRVLTLKPDSQSVKHAITKPFYDGVLRHPLCPPPKGHPHMSIFHGATESSEGGIPEVLGMRSRSPFTTAFYAIPSVHRQKDVSIRAFSMALQNSQSVKHAIMKPFYDGVLRHPICPPPKGRLHRSISHGATEFSEGGVLIIPGALGMRLWSPFMTAFYTIQAVHYQKGVSIEGVSIALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUA8</accession>
    <name>A0A2T6ZUA8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_980790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000101">
        <property type="protein sequence ID" value="PUU79035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUA8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUA8"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="306" mass="34561" checksum="C8649A2380EA06C2" modified="2018-07-18" version="1" fragment="single">MDKDQSDLVEWYKLETEFFPDHVRHTRHLGKARNRNEKIKEDWSNCGELGRGGFGIVHKQIEKTTGHYRAVKAIDKRQPFSVDHSRELLVMAILAKRPSLFVEFLGWFEEPETLYIAMEYLAEGDLTKHIGAPLPQETVRNISKQVLEGLKVMHQQGIAHRDLKPANIFVVSMSPVWVKLGDFGVSKRILAQATTTLHTQVSTPLYSAPEVLGLDPNSETSEYTNSVDVWSLGCVIYELLVGTKLFVSEFQLSGYFYGKWPFPEDRLRGLSPPTDDIGISLLKAMLLIQPEGRPTAGDALSHGWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUB0</accession>
    <name>A0A2T6ZUB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_980932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUB0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUB0"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU78994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="33009" checksum="1DF117EE3BD6ED91" modified="2018-07-18" version="1">MSTTLGGFIAGGIAACGAVTVTHGFETVKTRLQLQGELSAKSQTKRVYTGVFQGVRVILANEGLRGLMAGLGAAYCYQTMLNGCRLGFYEPIRSSATSLIYNDPHYQSVGVNVFAGASSGILGAMVGSPFFLVKTRLQSYSPFLPVGTQHKYRNAVDGFRTIGRTEGLKGLYRGVGSAMVRTGFGSSVQLPTYFFAKRRLQKYFGLQEGVGLHLASSTVSGFVVCCVMHPPDTVMSRMYNQSGNLYTGAFDCLMKTVRTEGLLAIYKGYFAHLARILPHTILTLTLAEQTNKLMKKIEQRLSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUD9</accession>
    <name>A0A2T6ZUD9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUD9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="73" mass="8551" checksum="D70BBECF80FDAF3F" modified="2018-07-18" version="1" fragment="single">MIAALRYYLKSLRKIPKREFKFPRETSPLGRRPRSFAPERRCGMGGGGVRVLLLLPVVFFYFFFVRVQGWING</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVC0</accession>
    <name>A0A2T6ZVC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1023733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVC0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015712863" evidence="3">
        <location>
            <begin position="25"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="799" mass="87749" checksum="F3C3EBBEA9A7A029" modified="2018-07-18" version="1" fragment="single">MGSTVSTLLASTVIFLALPPGALAANGVDFSNNLFSDLGPVLALFGEQVARQFMSQSMSWLEDVIFAMAPLGIITAIIGAVRVGGPNWLKAVVGRARESGAVAEMELMSSTSHEVCELWNGQAIVRVMGSPDIAEILYFEDMANGKDKCGLFTFKTAVKEGILKNAKETRDGSTQAEDNPPITAISEGAPGAKKNTSKLATSDSAPNISLNFCEIQRQRELWLFAILGFVLQFGSLVFIGVTHYHHKIGLGLDKDSGYAYPLMASGTLFLVMGMIACSHVVQASSVETTWVAENPFRILWLQKSATVNDQLFGSYALFADRERSTLTTSRRRTYTPSSKHSGSTKSTFAAALSFENLTIVGSFISLAGFVTQFVGIRALHWSASIAQLVVTLAMTAVRTWIRRNMSARPGAKTLPTDYEIDWLAVKLGTSVDGLWELGAHHHEHGSPDDDDDDDDDLGLEVLTLQRYRGYEATQDAHTEPMTDAKRMLKVREELGCLTDWMGISYPFALELVKCLQSLLSCFVTSRSITLEDDFASSTVFRWALPVKVGEKIEQITITARRSKDQRGNWLPWNVPISEICAIISLWSYRMKKYEQALGDTVDGDGSFWEYGHGAPAVLRVLGPATNLLVRDCEWWMDSGGRFVVVGTWELKNAKSSSKVTTLETKELSKTIAQANRSTAKNSTASVAPHRIVGTEPIYHESLVFVSETRLRRMCTQEILSSFMWAIAGTVQSIAGKTEPRSTTPPGDHKSKLDEWFDFKLENDFFQKLAETIAESGVASNNQDAYALIIPPFSAADKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVT7</accession>
    <name>A0A2T6ZVT7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_979114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000088">
        <property type="protein sequence ID" value="PUU79585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVT7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVT7"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="670"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1222" mass="135717" checksum="18A42D1F6FC8B27C" modified="2018-07-18" version="1" fragment="single">GEPLLPAREDVAPDIATPSAVSDTGGVQLGSAPQTPSVLAEVRNLGSFGSSRMQETSGEPGDEDIDEQLTRSQTWPPVDPSAAPNSGITVDDLGQSTGQQGPLRPNTAESSQGQPGRGGREGIEKEARKGSQDKTIVSETEYPAEESQKEPVYSEEAATVFTTSEKPITEFTENAEETITQSGYYNNHQIESQTQAPIKNPTLEPITAEHQLPAVTKNHPQKLLSPFEPLPSTEPLLSHKSTSEFSQQSQLPEAVETQQLHIAIPPSPQSQVQAAKETSSSGAEIPAEIPIEKIPTPAYTPEPEPETEPEQQTSINPSSSSSTENLNVSIEADPDFQVSVRKVSNESHPRRDSIEISVSRPGPFTLRERRSRASIRAQPSLDSLLSIASFIDDSRAPSPVISETRERDSILFRDDLPEICEEEGSPGRSKEEAVGSAYQSLFGGTSESAATVTVAASTGAGRDRAVSDPFTAEDKHTSAAQEKEEYKISTKPLEKPYSPEKQENNRKEEEQVLDTPTKSFVNKKLPTILETRKVSTEVHPPTPTRTASARERKFISTEDLIARLTGQATGHELRKSRSSGLQRIKIPSEDPMDILKRGERRRTTSPSLRRVGSQIDSPRTSGEHVIFNGERYGTPDKAKARDVTSSAEYYEAWGDKDGEPMSPTRPPSIRRRQSMQIVDLENRLQALAAENTDLTHDKANVEKSLNEAITRGKSEAKTLKLDLEEKKSLLEEKDSQIEELQRKIEWYRTEVTRLSQTNDSLSQTNTSLSTSYKLSYAALTAKYDKKQEAMLKLSREHSELQRNFTEMQTGMESIIRTELSEKDAELERLRVELERAREEVRKLQNKVSARQANKYIDAKDIAYFNSSCKNIFQSVKIFCKQFSSFSTGKKCVHVHRIKDETARDRVEAVMLDDRGVRRMLKEEKRRPEVFMAIVMRMVWELVFTRYLFGLEAEERRKLLSLEKILTDVGAPAAVHQWRATTLTLLSQRPAFTPNRNADIESVVATILNQLSTLLPPPQQYIQLAHTSLASIITSAVTLAIDMRVQRAEYVMLRPPAPTYDENGDVNNTVPFLSSRMANRGSDPATDAELEAEGATVKAILFPMVIRRGNEYGEGYEQESVVLKMQVLVNRPQLRSESRASARPGREREEFGGLGGVSRLTPITDASPRTTPEKSRIAEVTGLPRIPESTIRLVSEDEGNARIERMQRRRASGKRSGSGSGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWL5</accession>
    <name>A0A2T6ZWL5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UreD urease accessory protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1080697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000079">
        <property type="protein sequence ID" value="PUU79866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWL5"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="329" mass="36534" checksum="91287FA31770DAA6" modified="2018-07-18" version="1">MPKPPPIPPPLTPSKPTPLPGHGSIYTRLLPPSQTTLPHLHFTYPLKLISTPSPPSTTNTYQTVFQLTYGGGLVSNDQVHLRIVLEPSSKLCLLTQGSTKIFKQKVDGDITRQALDVRLCQGARLLLLPDPLQPFEGSVFSQVQRFWLEDEEEGKRGGGGMVVLDWVTEGRAARGERWGLERFESRNEVYSIGSTRLLLRDALVLNSLPSTNSQEESLCSRMDGLVVFATLIIRGPAFERLATFAKNKFSEEPRIGGRSFGTYDDGKVRGDSGRNRRDVLWTVSEVRGFVLVKVSGWVLEEVRGFLREILIDGGDVIGEFGEDCLLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWQ7</accession>
    <name>A0A2T6ZWQ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1063905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWQ7"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1186" mass="129649" checksum="337CE6514529F16E" modified="2018-07-18" version="1">MCFGLDFLSGDCSPEDRTILSGSELHIGLSWDAIDGDILVPPLECSEEDQEELSIPTQCVMPISVREYTRKEKGKEKMIAHEEKLPPSSMVKFQYWQDRNPLCQNICAWFNDFITSVFGLGPPRFLVLCVKTIKYEQMPAYYCPFPNFSDPQLGMWNWMWRDYADRIVVNVPEEAREILGDSSTAVLTMMFFAFVRTGYSDLVGTESFTHNLLHGGWNMALQRPPRQTEPISSVHADGVPTGHRGMSASNADDYSIRCPSPVSSAFLGLDGNREFGTQIYSWRESPSWQRTESSYGRALDYSNLGLFRLLKNPNRMTDPPTTEFQQVLHSGQEGAERERQCSIGWTTYGAWNVSNKTRELKRGISASPSSHSLESHLSSLLFVLDSPRDRAEELSLNSGSIYGALGGIGSKARDSLPGRASGNSVQSSRTMRGWLKNNVLMLITNGEQSIRSGCTSFHIAATSNDSVGIQYGPFRFRMEQDGSTTCVIDDSKLRSGSGQSLKNIGCRVGAYIGLDKCAICQEGWTGGRSPEIAKSRDGCEWVLAKLPTYLGPGWPWAERRIREINSPGGYPSGSVSRGSAMENIPHAAHTRMSSEEPINASYTRSNISEGNLNSVGSDLIRSNAAWSTAAESTQPTVLSRRRSLLESQSNDYVTNDSLELPHPVDFSSLGSLQLTATPNADSFECEYWERYGIEIGEEGEGGWRDLGQLVSEEGIFGGSATTAWPHSRAYTEAGIRGKPFHSKGTAPPRLRPLLRAAELLELVSFDLRLVSQTDLGFLDSAVSLLYQFIRTHKEAYDGAPRGYTNTGNCPGRRPKGTGPHSRAHTEAGIRGEPSHLELPAPVSGDALVKSTAPPKLRPLLRAAELMESVSFDLRLVSQTNLGFLDSAVLLLDLFIQAHKEAYGGAPRGYTNTGNCPGRRPKGTSPSDWEGLFREAGSQTEPVTSLTVAPESVAYAQVITGESSISKSLVSSAEETGTEPVTSLTVAPESVTYAREKQAGRKDRFGFLDKGSSFNTTAPGCQESSASGTTSRNISGTCSGTAVSLIPSRADTKPKATTARGSVLSSSGNDQFSTAAVSLATKMKPPFPSGISYPKSQEFEVQRINQKGSKIPVFVKKAGGRRDIDERPLNIITPIPRNRENSPFNSMVPASSLRRLLFERKNLGEHGGSPTLRKIGSRLPYKRHEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWT4</accession>
    <name>A0A2T6ZWT4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1124362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZWT4"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05392">
        <property type="entry name" value="RasGAP_Neurofibromin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054071">
        <property type="entry name" value="PH_NF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21877">
        <property type="entry name" value="PH_NF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1202"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2587" mass="290178" checksum="5432553230C0D955" modified="2018-07-18" version="1">MDGDRRLVQTLLERLSARLPFRTGDDLSDVRRDEVIALARGSLIELARAQIDIVVDSIAKHLESISRGPGDPAPRGRPSVLLTQTYLVEVLADCTGAHWDSIDAAHREMMEETPAAEPLRQPGISTRKTRRREREPPPLDDIQAKYVLELLLRLTATPLDDGHGSSMGRKENNNNSHSEERSLDGLPKKASDLERASFKVIEYISASNWALVFHTMSQRLKFLRTTASDDSDASGLQFIAHMWINQEKLSLIIKEISGSFLPLRKPAQNMLAALLPETIHRWIEAHPKDFVDLHVNNRRLEKGVDNLFDIATSLADSAKRRTIIWPLQTALILLLPDVFWTLELRSEQRGSLSKKVAFLNDLRRSLRLPRSSDIAASCLIIMCRAGSLFPAESDSALLGFALDVQNEVTEEIFRRQQFGEDPNVDRDIMIKAFVSSARLGVDGVVENLLPRCLDKNSPITFKITVFAGVAVLASQNNAEIFDALYHAIAPEVRELFINIASTRHANTSSTGASSLAGSTLNSQTRHKNLSTDSIGSSELLYQLLELLKIRPLLMYENLDAGAEEWDRLGDRMISSLLRLIYDDDEFVRHSAVVFARRLLSPEAFQMTTDMRLGQGAISVLNFFWKATSAIVATLSKKLLDFDFQDLALKGMLELVHGYLETRVSIISSRKDITEGITDIPERTIANVSLEVSFLVLLCSSDLDICSITTHAIALLCEEGRLTENPDDLARSNLTVMRNFPVYSELSLQTFRITGPVAFQKRLRRLLTRMSMPGPGILTAWEAVFTRWRTLSRHILSPGVASAGGIDDGLFAEWRNYSGFLASIAGCCIADLPHQLRADDPTTSGLRWIDRLASDGDQMSLLERFMKQCLQLLVCKLVNVRENIREVLGTELNPRLYLQLFRSLETEFGVLFDPGFKDPQSESRTLFAEQACSLLKTIVERLEDAQDMFLTVDLGALTLSLARYLNTLKEDYTTLRVKIRMCQLVELVARKKELVNLRQDIRVRNNLLQILSEWMPRPTKETNYPINPRRDELLRPQRDLDRACLKALVNLLHRLPLQPPETAHDGADVVDARSQMFCSYFTLFLSLLDSSQLEGDRRRELQAVSLAKDDASSFQDLAIQALSNLLSANVDVGLKFSLEIGYHDDLQTRTAFMHVLTNILTQGTEFGALGDSAIGEKYEKLIDLLVNDLQFALALCDSCPSSEVDEMSIALLNIFDSRGLGLTLLKELIEQEVANTESESELLRRNCVATKMLSVFAKWKGSEYLRNVLQKVLQRVIISSDKLGLELDPARTPSTEELHRNELQLRYVTKVFIDEICKSGNIAPNSFRWICHTITTCVTSRFPEAKFTAVGAFIFLRFFCPAIVAPDSEGLVNNIPNKEMRRGLLLIAKIVQNLANNVLFGAKEPYMIPLNDFLTANICVVTAFLREISSLPKKQEPVVAQESFDFGSSVALHRFLYDHWEIVRQKLIFQEKHKARLNGEKSFCADAGPSNLQLSITKFSGLISTLGAPPLDISLGRPTLTGNIQPAYSRYQHFMLRNSGRSVESILAARIVYDGGETKDNMPVICFVLRNINIGTIDPDLLIYCYLKIASRMWHKPFAVLIDATCYSLNNEMPDELYKKIDSLMPPEMVKNYSRLYIYNMNTAFRKFFRRQLRYAVRDESNAWNPNNIDFIMLGSLAELQQHFNLGSLHLPKETMSFLSDPRYMYHHITRLSKTKGKIEVVFKIGTQYIQITPTKKQEIVAGLKMSATINDIFRLNDVEEANASFHTDEENAFGIKTDNGKLTMFFSSPKKNEIVQTLKNSKSKYSKDNRPSKLNERTIRPEDVPGTLLNISLMNIASHDQYLRLAAYNLLCALCQAFRFNLDRQFVSAKGLSIPTDSVALIVGVSEKLATAEPQLTFDFLSEFFVGWEKSHPQQRPLNILYMAPWLANLHPQVLMGGEDAERGKERLAAIARKMIDITVQEPRLYTSFQQHAWCIISKDEGLLDVFLDELVKSAMNFGFGSEGAETIGSIAASFGTLTIRGKIIARIRKVLNRSSLRPMRHLVDNIVWNEICVLLRLCLAISFDSRVQAQMYLPELFHIITMVVNCGSILVRSTVHSLLVNTVHSICVSFPLEDAKLTQLKGILVSLSEPKLCLLFSLNRPTSRDALAIQEQRGSETTTATSMELITNLLLEIVSVAAPSTDMANIWRARWMSLVASTAFQSNPAIQSRAFAVMGCLAREDVDDDLLYQVLVALRGALARYSESGDHEMLTSIVTSLTKMMENLQPTSRYLYQLFWLAMSLVRVGHGQVFTCSASLLEATLKTIASSGEFKDNRMVPVLLQGRSQLEEATAGIDDIYNIKFNLDSFHFAVCATLTKGLQDPSTKPSALRTLTAFLEVVSANTPENSHWGIDVPVPPYLSVVLTRATSISEIKEVLWIVGIALAEEETTMDNSSGGGGNSDMCTKLTPMIDSMSEQNLLLIGALAVVDFRSCEESIQKLTLALFTRMAERRPEVLLLLYDHLLECLDEVLNSSHNPMLLKEANALMCVVSMDSRFANRGSTGKETLASRLTRWGLGGIWTATSFRGTKEFEKRCAGLTDRLIEVCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX29</accession>
    <name>A0A2T6ZX29_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAPP trafficking subunit Trs65-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX29"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX29"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="460"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="557" mass="60795" checksum="DA05F7D15A05B909" modified="2018-07-18" version="1">MPAAAPRKKTHARTNTVELQESARLELVVPQASDLDISRAIDEALKQDKQQVSTADGGISAVSAIEQRRSLFYDETLPVFVVLQLLIPLEDSVYESYLSRLAVSLEVAAVDGQRQQQQRQPQYGGRNVETIHLLFQTVVDENETKRIVIDNGAQRLAIWKIDVPLGHPRARLNNPKVVLTASATIRPAELHKPVVEDEYLSTRQPVGINLLESFAQDPYLSTVAPRLSASRVSRVIPVTQTPQQALRPFGYAAKCNFNIYPAINIRLRYSRIFSGTKQTIIASLDLEVTHFSECDVTIESVEIALSGGKADPLTDSPSPPLPIECRPRDDITFLFVLTPTDLLPTSSSPAPTSSNSPIRPISVTLRATAHLSSICHPKIFTNWTTTVDFSPPQSPAFQPSPGIQRAHRPPSLGSIIHGATVSSSAGIRPVHQSAAPSPALTFTPPNHSTPSFVANPAPESTPGLTITFSGPSRVYVGEVFVWTVFVVNRSQRTRKLALIVPPKRRKAGEGKSLPPRPTGGEDVTEAVLDEAVVYQTHRAQYLEPAELVPLVNDVRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX78</accession>
    <name>A0A2T6ZX78_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate dehydrogenase cytochrome b560 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1080295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX78"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX78"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20134" checksum="FD982C9D9DF7D102" modified="2018-07-18" version="1">MFMFTRSSARFTALTLPKPFFIARVPLMAAQFRPITTSTSTSTQNVSPDNAYSILVAQRKQRPISPHLSIYRPQLTWCGSAANRITGSLLSVGAYSFFAAYAVAPAFGWHLDSTTIAAAFSGLPAAAKFGIKFAVALPFSYHSWNGIRHLLWDTGRALDIKDVYRTGYVVLGLTTVSTIYLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXS0</accession>
    <name>A0A2T6ZXS0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_744794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXS0"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31474" checksum="B39D40ADAACC53E0" modified="2018-07-18" version="1">MAPPPEVPLPQRLMALAQTLQFGWFVGHFTLLLTTFRYALAAIKFSTNTRVASVCYRLGFLSAAVTYGIVVYKAYRPRVRNGQLPGGQAGVLKVLADENVQYLFMALIWLYSKPIFYALLPFAVYSTFHFLTYLRTNLLPTILPPPPSSVASPGGAKPQSALSEFIAKFVKNNYDYSMHLVANLELFLWARIFCGAIIFRNSWILLTIYTIFLRTRYSQSPFVRDALKGIEVRGNALTADNNIPDGVKSAWNTMKSGVRSFGEFTDLGRYLGGAGAGVTKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY46</accession>
    <name>A0A2T6ZY46_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phenylalanyl-tRNA synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1063482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY46"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenylalanyl-tRNA synthetase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU80394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="23468" checksum="E77ABC1A1B0F44E2" modified="2018-07-18" version="1">MEHHEQSTHLPSHISSALSRKSHLQPSHPSSITRPLIESRSPGPTYEYHNDLSLRVSVHQNFDSPGFPIDHPGRSRTDHYYVNKETILRSLRSGHQADTFRSGTSDRFPSSADVYRLGAIDRSHYPVFHQMEGARMWSRRECKARREIAAVIKYEVEGMPKHGIDVEDPNPPFYEKRNPLQVEHTPEEARAVGAHLRLCLKHVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYB4</accession>
    <name>A0A2T6ZYB4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_734879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYB4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015413108" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11708" checksum="853316BFA55B14B4" modified="2018-07-18" version="1">MINWVFFIFSFVGDVDAYNTLQGVTESDGTLWRCVQLNFWFWYESAAPQSTHHFPSPSVLCCSRPKTSGMPARQEGKDAIGHGFQSHTEDWRWSVHFLFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYC9</accession>
    <name>A0A2T6ZYC9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enolase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_974831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYC9"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="387" mass="42924" checksum="1CDFF41E28353BE5" modified="2018-07-18" version="1">MAKIISIEYFRVLPRWLFVKVTSEDGQFGWGESTLEGHTEAIEGSLDELIGRFVGYEADDIEHIWQTAWRLGFYRGGAVFMSAISGIDIALWDLKARKLKVPLYSLLGGKVRNRVAVYAWIGGDRPSDVEEQAKQRKAQGFTTIKMNATEDLGWLDSPSALQSSVERLKAVKAVGLDAGLDFHGRIHKPMAKQLAKLLEPHQPLFIEEPLLSEHPEAVKHFSQQTTIPIALGERLYHRWDIKPFLEASSIDILQPDISHCGGVSEIRRIAAMCEAYDVGLAPHCPLGPIALAASIQIALSSPNFVIQEMSLGIHYNKMTPPGAGTYDLNSYVKDTTVFEVNGGYVKAPTGVGIGIEVDETEVRRVSKDCKAWRCLEFHGPDGAVREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYQ9</accession>
    <name>A0A2T6ZYQ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_974391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYQ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYQ9"/>
    <dbReference type="OrthoDB" id="422187at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="2">
        <location>
            <begin position="16"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="246" mass="27022" checksum="B90A640CF506D958" modified="2018-07-18" version="1">MAVDYVRQNMSDTYEVVGGYLSPVSDRYNKAGLASATHRIRMCELACEQTSDWLMVDPWEAIQKEYQPTAVVLNHITTSVNDQLGGISASSDPGAPKKPAQVALLGGSDLLQTMSQPGVWSLEDLDLIIGSHGIFVIERSGSNVSDALAPLNEWSEKMGKSWLENIQVVRQLIANDISSTRIRQFLRWGMSVQYLLPSCVIEYLREHQLYRDPVEDNHPLGDGKGKGKGKMVEGDSKTAGDGARVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ53</accession>
    <name>A0A2T6ZZ53_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_973704</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ53"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ53"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="501" mass="55351" checksum="164762FBF8D264E2" modified="2018-07-18" version="1">MVDRDHKPPELDDRPTSVSEEGGPSAGVVEGGEELTARVVDLKAERALCRKFDLRLLPVLAVMYLFNALDKGNLGNAKTNGFEKDLGFTGNQYNILLSVFYIPYVLCAPPVGMLGKKYGPSRVLPIMMFTFGSMTLLGAACKNFGGMMTVRIILGAAESAFFPLVIYYLTTFYRRGELARRLAIFYAASNIANAFSGLLAFGVFHINSHLSAWRYLFIIEGSCTALFSFFAYWYLPMSAAKARFLSPEEKELAFYRIQVDSSSIVDEKFDLRESIKVFRMPVAWAWLAIEMCLGVPLQSVSLFLPQIVGRLGYSVVKTNLYTVAPNVTGAVMLLILAFTSDFTRLRSPFIALGFSFPLIGFIIYASIDVLHDKKIAYFATFMMCWGTSAPSVLLSTWYNNNIAHEGKRIALTSVGVPVANMMGVVSSNIFRPQDAPDYIPALTTTACFGAAGMLLVGSLGTYMVFDNSRRNRAQGVEIDARDVATKVLKDGPASPNFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZA5</accession>
    <name>A0A2T6ZZA5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Surfeit locus protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1063162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZA5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZA5"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="188"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="425" mass="47415" checksum="6291C271B6C3AC12" modified="2018-07-18" version="1">MADIEERICGYHNAFEGLLSLVPENKSDPSQLKRKQTKEESKKAKKAKLDSGSAMEGTPAKVKQGDEKRTEGGDETRKKAKMPKRRREKKPKIAVQSIGPGRSEEVESLGNESGSDIDIQMDSGDSTPHSQSTTITSPEAGELASKRAPKVELDPASRAEKRALLVARIEELRARRQAANGAGAKNRQELMEIRRKKEEARKERKKQQRLEAKVAEEAKLKEAQATREGETSQQEQLKKGPANNLSFSIVTFDDGQELDATLTNFKKTRKPKGPTDVLGQLRHVEAKKARRQTMAPEKQAKIEEKELWGKALGQATGEKIRDDEQLLKKSLKRQEQVKKKSEREWKERLENVAKSKAMKQKKREDNLAARREQKAAGKSGKRVKVGGKQKVQMKKKKKGARPGFEGSMKSKHGGGGGGHPKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZC1</accession>
    <name>A0A2T6ZZC1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_973300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZC1"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36262" checksum="94A9F1D19E9D9D34" modified="2018-07-18" version="1">MRFKSSDPNTDIAHPNGQRGVKKPAVEKQTIEKSVAEEPKKNSISKDEQIGERLKDVIINHRKGLQIMYGETEAELDESLEVPIKRGEEMARKLITMGCNIEIAKNLALLTLYDVTVLIDDSDSMITEENGQRKKTLIRFIDHITEICLMAKECGIFAMRFMNSGGGKNNWTGKSQEYLDHHSYGGVTRIGTELKRKILDKFVIGNPNQSKPLLVLIVTDGAVEGERKGHLKKVIQGCVNEREAACKGRDAVKFQFSCIGNDPGATQLLVDLDEDPDLGESIDVLPVEFDLECLFTEKWFILPKILLGAILPDVRPPHLNSLAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZK7</accession>
    <name>A0A2T6ZZK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_669567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZK7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10849" checksum="4BFBC74B0F2BFDE5" modified="2018-07-18" version="1">MYLCASDATLSTFALLQDEHLVSSLAGGGVLFSSFFTKITILRENWEVLIIIYYSSLLFLFVLFFPRLLIAFLWDEYLLPTRLCTASKFLPAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZZ0</accession>
    <name>A0A2T6ZZZ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2-oxoacid dehydrogenases acyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1078012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZZ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZZ0"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="64"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="368" mass="39454" checksum="FB64BDB5B8C5CF13" modified="2018-07-18" version="1" fragment="single">MAIVGKPLVDIDLQANINDPEQLGEVQGEAPAVSAVSERALKTSGGMDESGQFLTSTTRLHGSLATPAVRRMTREHDVVITEIAGTGKDGRVLKEDVTRFVEARKSGELVSQLSSQSSPLRPLQTQTISSGAETKVPLTHIQSQMLKVMTKSLAIPHFLYSDEINFDPLIQLRSTINKSLDANSPVPRVSFMPFVIKAVSIALDQYPLLNSRLEFDADSKASLIMRSQHNIGVAMDTPAGLVVPNIKNVKNLSILDIAAELKRLQELGGEGKLTPADVSGGTITVSNIGNIGGTVVAPVIVTGEVAILGMGRAQKLPRFNESGGIVAETITNFSWSADHRVVDGATMARMAALVRELVEVPEKMFARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A067</accession>
    <name>A0A2T7A067_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A067"/>
    <dbReference type="STRING" id="42251.A0A2T7A067"/>
    <dbReference type="OrthoDB" id="5379735at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015719178" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19212" checksum="0A6E058F58B12E17" modified="2018-07-18" version="1">MKLTLIAAVSVLSTLVSGLALPDLTPRSLVIHPEIGAVIKEDFPKTSFPATPANVSRSNGQHNVKTLLGFDVPPCTGKCTISFTDALTATDSRRLQLFTTIGYPAKENTWESKPSTNNHIGTFLVSISGPAVVVEDFGLTFECPKTTAKYGYEVQPVWDDDHVTWDITTGGFIITCPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0C2</accession>
    <name>A0A2T7A0C2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1077745</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0C2"/>
    <dbReference type="STRING" id="42251.A0A2T7A0C2"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="53"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="234"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU81150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="395" mass="44657" checksum="F4E0786F3C6E35A7" modified="2018-07-18" version="1">MATEGLKDIEGQIESNYDETVDNFDSMELKPELLRGIYAYGFERPSAIQQRAILPVINNRDVIAQAQSGTGKTATFSISVLQKIDLSVKQCQALILAPTRELAQQIQKVVVAIGDFMNVECHACIGGTVVRDDMKILQDGVHVVVGTPGRVHDMIQRRALKTDAIKLFVLDEADEMLSRGFTEQIYDIFQLLPQSTQVVLLSATMPQDVLEVTTKFMRDPVRILVKKAELTLEGIKQFYIAVEKEDWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTEKLTARDFTVSAMHGDMDQQQRDLIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0H8</accession>
    <name>A0A2T7A0H8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_632369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0H8"/>
    <dbReference type="STRING" id="42251.A0A2T7A0H8"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015730794" description="DUF7137 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="4">
        <location>
            <begin position="93"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="27706" checksum="B4E46E407143218E" modified="2018-07-18" version="1">MRNAHLLFSLILSVAAFLASANPTVAVLQTSLVRRADDPSKTTSASNGAPTAGEGDPIDGDATPTADPTDQKTDQSGSAKPSSTKSKKISSDAQPGGVVMQTPALIDGYQIYKIGQPVTFKWNYTSIQASPTALNVEAYCTDGATYFTIAGNVSADTTEVVWDTGDYQQSATAKLPVATYTLWIYDASKDRTAVPSPGYLYGYNSLQFGMYSPKPAVPLKDFQCSACDFNGAGLNDPRTVRALLGMGLVTALTFVWFIAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0P1</accession>
    <name>A0A2T7A0P1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0P1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015648885" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10369" checksum="3D5EACD117C309D3" modified="2018-07-18" version="1">MIVYVTFFFLFLSHSLARGSRTRPVRMMSIDSSGHQKLSPQFTSIAQYSTGNTYEKAVLWHKFVGDFTLFVQNAPLTILKRHHFIERGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0U2</accession>
    <name>A0A2T7A0U2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_894348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0U2"/>
    <dbReference type="STRING" id="42251.A0A2T7A0U2"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01460">
        <property type="entry name" value="vWA_midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="306"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="508" mass="57353" checksum="9E087F42907BB4B8" modified="2018-07-18" version="1" fragment="single">QSGEEAKSGEPPETNGADANQEHGQKFGQASVQDASPQNDDQVSKDEHLKEEQESFRKVGDVLEKWHRRRREILDAQKDTERPQVDNMELDDPEFEHLPDEEAVADTQALGAATEDQAHSLDDSMAIDSGTTQPQETFEDDESELKEGNATDDEMRSSEDRDADNLESAEECSVGAIIGKALEPKSKQQIFPREDAESNLEPEDIDMTDNELGGGNSPPSQLVNSRSWVESRDLWRKHEQSTKDLSMGLCEQLRLILEPTLATKMRGDFRTGKRLNMKRIIPYIASQYKKDKIWMRRTKPSKRQYQVMIAVDDSKSMAESNSVNLAFETVTLVAKALSQLEVGQISIVSFGETTRLIHPFDQPFTSESGVKIFQSFTFDQTKTNVKTLVEKSLSIFESARTNSNASLWQLEIIVSDGVCEDHDTLRRQVRKAQEEKIMIVFVIVDSVRETSILTLEGVKFERDENGGMALKMYKYLDSFPFGFYLVVSDIKELPGVLALALRQWLAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A119</accession>
    <name>A0A2T7A119_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1122196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A119"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="170" mass="19004" checksum="6678F35FC6CCDEDD" modified="2018-07-18" version="1">MTRSFTSPIEIFSVIVKEVQFTYNAPGRDSMAKNRLLVDQGTFLPPFATHNSWQKHSNAQFLAASAKLYGYRISPNVNSIQATEVAAKRECLQVLEHIPSLRLPPPAGSNSKRKLNAKRLKKALMHERDFASVSADKGIRTTHKAKTRFRRAIKQALVTPHGTTGAFIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1C3</accession>
    <name>A0A2T7A1C3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1019344</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1C3"/>
    <dbReference type="STRING" id="42251.A0A2T7A1C3"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="480" mass="54346" checksum="46109029BB45B0DF" modified="2018-07-18" version="1">MTSQSNLIMVSNRLPISLKKRDDGEYSYNMSSGGLVSGLSGMTKNTTFSWFGWPGMEVPEDDMEKVARELAEGYQAVPVWLPDEMADKHYNGFSNSILWPLFHYHPGEISFDEGAWVAYRDANQLFAEAIAKTLKDDDLVWVHDYHLMLLPAMLRKAVGDRVKNVKIGFFLHTPFPSSEIYRILPVRKEILENVLEADLLGFHTFDYARHFLSSCTRILGLTTTPAGVEFEGKLRRVGAFPIGIDPEKFEEGLQKQWVQDRIAQLEKKFQGVKLIVGVDRLDYIKGVPQKLHALEVFLEEHPEWIGKVILVQVAVPSRGDVEEYQNLRAVVNELVGRINGRFGTIEFMPIHFMHKSINFDELISLYALSDVCLVSSTRDGMNLVSYEYIATQQKRHGVMILSEFTGAAQSLSGSIVVNPWNTEELANAIHEAITMPPNRREANHKKLYEYVTKYTSSFWGQTFVGELTSLSEKANAENAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1F3</accession>
    <name>A0A2T7A1F3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B9Z19DRAFT_971662</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1F3"/>
    <dbReference type="STRING" id="42251.A0A2T7A1F3"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="21">
        <location>
            <begin position="248"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="20">
        <location>
            <begin position="812"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PUU81495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="927" mass="102021" checksum="E670D99A210575D3" modified="2018-07-18" version="1">MSARLLSAQAVLPAFSRHPQRHVAAARRLLSSPLSTASTDRYSSTSAGLLRISYPLRSRTFLRVGQLSRSHSGAVATRSLSFSTTIPKLVLKFARVPAAFGGAVVASIAYVQYQAQQAGTYAIGIFNSAGELVGATIAGAKETAGSLYGGVSEGVSGLEVPEWMQNLLSFGGSGGEGGEGGGKKKSDDEGGSRTYAAGAAAVTAAALGYGDDDVRSEQQSAKDDQMMVLTKKMIEIRSILQKVGQTGALQLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRPIELTLINTPDSPSEYGEFPALGLGRITDFTQIQKTLTDLNLAVPEADCVSDDPIQLNIYSPAVPDLSLIDLPGYIQISALDQPEELKTKIAALCDKYIQPPNVILAISAADVDLANSTALRASRRVDPRGERTIGVITKMDLVDPARGNAILKDRNYPLRLGYVGVVCRAPSTKFSFGRNVNITSAISKNENTFFGAHPEFAAPDCGVTVGTTNLRKKLMSVLEQTMAQSLQGTSDAIRQELEEATYEFKVQYNDRPLTAETYLAESLDKFKHSFKDFTEHFGRPQVRQLLKHELDQKVLDFLASRYWNKPLSEDKSWNRLDEPPISELPNVDSENLYWHRRLDASTSALTKLGVGRLATNVVANALQQHMDRLISESTFRAHPFAKQAIQEATNAILNERFYSTSDQVENCIKPYKFEIEVSDREWAQSRENSQNSLKEELKACEEALKNLKSNIGPKKLVQVMSFVDKLRQGERADMKEGTEAFGFSQPLLQKGREGVFLRDRAEILKMRLYALKSKQCATSANKYHCPEIFLDVVAEKLTSTAVLFLNVELLSEFYYNFPRELDNRLGRHLSQQQVESFAKEDPKIRKHIELQQRKELLDLALEKMESLMALEKSKKAPLVGEGSVVRTGRWGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1M7</accession>
    <name>A0A2T7A1M7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_582094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1M7"/>
    <dbReference type="STRING" id="42251.A0A2T7A1M7"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="742"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="920" mass="102005" checksum="FBE5C9E9FE17B689" modified="2018-07-18" version="1">MGGKKKNKVASNPARGFATTSVPSKAKTPAPAPEGTREKEINTLVVAEPPEQGLGKADEVPHIPNEEEMEEHRLKALVDKLGQRAKRETQRIMAKVEVERRTIRSICYPLRVNKLLEFDFVRYNNQPKTTGGVKELGVGDQILALAKEEFTRMHQGNESECKRGEALLLNAWILQKTFVSMGFPKGKVEEGLQALTGHGSTVLDKEKGLDGALEEMFDWLALNCEVEELPGFYDELSKGKKKDMGSGSSDGTPSETKPDSGKSTPQQPPRADRRHLTAGKLRPVADWSLELEGGDVLDRGETVGDKESDSEDEDVEVAPEELIPQYIKLQTQKYYLHPASTIITDRRVKGKNEIKASSIADVSAAKAEQLNRIQSKISELTRDPLFDLREAEGVWRVERLRLEKEAWVKRQSRGGSTFERGAGASVGSIVSPEGDEVKEETGSTSLIDLPHTGEDSDMDLEFIGGLFEPAPTEESTVVQGGENEKVDIRDFELVNHSGGNFGRGKPKGKAGVGTTMVKKVLEEFCRSRDADSKIHFEVIQGTSISARSKLTITWSFIPELSSVDLSPLTSTLDPGPPPPVIISTLGPLRTTFSMASIAAMSKDQADGFIATYALFKLCSKKDEKIYLRLPSVWRELWFELLNESQLESERQEREVLRSLEKTLKIENFGLSGPDNLVEKKAQVTKAAGPKERETTTRGVGPESMASEAIKKDWFYRTNRSGYQQMLEHRRQLPMWAFKKDVLAAIESNQVIIICGETGCGKSTQTPAFILEHELSQGRACRIYCTEPRRISAISLARRVSEELGERKSEVGSKSSLVGYAIRLEGRMHSGTRLIYATTGIVMRMLERSPELEEVTHLVLDEIHERSLDSDFLLLVLKTLLARRKNLKVVLMSATVDADKFSAYLGDAPVMMVPGCCSRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1W8</accession>
    <name>A0A2T7A1W8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_572636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1W8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11329" checksum="A94ED394681FDE8C" modified="2018-07-18" version="1">MSTNHIVSLFSLLFFINTLLSFNFSLFPQKRKDSKSLDKAWCCGSAYGITDFLFSLFISLLFCLVNLVTVQLESNQWANGPSNKFFSSFPPCRGLCVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2C1</accession>
    <name>A0A2T7A2C1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2C1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="62" mass="7051" checksum="02F25AF7EFA1317F" modified="2018-07-18" version="1">MASFFILLSFFCPSSFYFFSYCTILKLLLPYYGSFFFSFLPFSIFSCTLALISPGANHGSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2X6</accession>
    <name>A0A2T7A2X6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1075795</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2X6"/>
    <dbReference type="STRING" id="42251.A0A2T7A2X6"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022577">
        <property type="entry name" value="TBCD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12612">
        <property type="entry name" value="TFCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="4">
        <location>
            <begin position="341"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D C-terminal" evidence="3">
        <location>
            <begin position="885"/>
            <end position="1045"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1139" mass="125673" checksum="A33276CEFABB5106" modified="2018-07-18" version="1">MDAPEDRDVKLQKVSGDLLLRFKESVPRLLHEDGSTGPPRSTVDSKEVDSMRILIEPFQESPQLLDPYLTSFLTPLTSAFLALLDTSNAKTSRPPLLKSTGFDRAEISSHEAIARLLYTLCKIRGPKIITRFLPNEPRWLEPLTNLLALRSTESSSSWQFRFILLLWLSHLLLTPFDLSTISTPSTEPIQLPEHLDIEELPDLSRRLLQLAIAHLASPGNRESETASLLIVRLCIRKDMGSLGLLPAMISWCMDTFSIKQESTDSAYTSLFRKTSVVSVLAGLLAQVDRTAVTPFIMPIFRLVQRIESEDGKEWDSANMRRLGMKIYRWAAILSLTREGEANSEDTIVEDIIERLLNSLGDRDTAVRLGASKSLAVISRKLPPDMAGEVLEAVMGIYEEDIFYSPSYGPNRKKMLTAVNAEKWHGATLTLATFLRERAVRSTDVLRRVIHCIITSLSFEQRRTTFAAGGNVRDAACYAAWSLSRSYTTDELKAVGDFDQRGFIQQVLATELIVAGALDPLGNIRRAASAALQELVGRHPGMVEEGIKVVQVVDYNAVALRRRSVVKVAAEAAELGSGYWHGIVSGMVEGWRGIGSGDVEGRKLSGDGLGELIYIALPGDDECPDNKMARRVVETISSLLRRIQTDGKSDIEIYHGATWALASTILTVPPKVLTPIRSSLLLPPFEKLTGNEFLNTLLRPELTSESTSRLVFALCLLNPLPIHVIRLYIAILEASLDRNEDIVLQQAVPAAKRLIALSSLPNRENLVTSWNRRASSNRKKRGYILVLGEVLPFLPSSTDLRKVTVSSLLKAAASGEVECRVAGITAISRGILSEDSREDVIQAIVNSLDDYEVDSRGDVGSWVRSEGIKAVLEHWERLGNEDAQWQILERIVRLCAERLDRVRVRACEALVKISESEKWRDLVEYINIEVLKSEISATSVSSPEYFTSLVLLLNHPRLSTPFLKGLILSAGAGSDSLLKTSRAVLLSFLSNTSPTPILSTLTSFLPHERTTVPTLEVMSAILESISCTPPASLFPSVQKAHYKSANHGRLSAAVRVYGGIYMNEDKLGRKAVVDKLVNMLNHPFPKIREGAAEVLVGVAGCLGNETNGKAIEALTGWDWLSGAKERGAVVKRVRGCFDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A333</accession>
    <name>A0A2T7A333_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A333"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="248" mass="27400" checksum="FE7B345FB97C9EB5" modified="2018-07-18" version="1">MANFTPPTTPSSQNANSTITHQASTYSTTDQSTGITPPPRPPTPGPSPEPTAKVQEIAKSIEAFMALLPILTEFPEAIKNPHTIPADVVVLGRLLTEGLNYFADLVDWEVVSEGFEGGEIEWGEEDDVNFTLICFSYHPFYLSLFRYRNLMDLPLLLLEIGFKKKGEESLDKIVIKQTCNTVSALRPPIAVLAIDTALAHHWLPVEHASFTCLQSESAQRQLLAPVGRLRFKSNTWYCTAKPGAPSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3A7</accession>
    <name>A0A2T7A3A7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1075542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3A7"/>
    <dbReference type="STRING" id="42251.A0A2T7A3A7"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="466"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="742" mass="79474" checksum="9F248EE446BEE52D" modified="2018-07-18" version="1">MSHSNSVNICLPGDRGCCPLGTCICMLRGSVITQTSSYLGTAPTAQQAFALMSGRSPQQFQVSTSVTCRPDYHETALPQKAPSLEDIQSVILGVDSTNLALADYLSQQDRSAEPFPLVRHSVSTTGASFCDDSMGGDYTFSMDGSLGVCAPRMQPQLSSSPSGCYAGGDESSHPMTRHSRSYSNASYRSRSSCLSSQGESLSPTDHFPTQNSWAPMSRETSNASLTHGATMLRLSSSAGNSTTGSGGGGDYGSFCSKGGLDAMFGFFASEGELSSSLDKAAGQHMLKRPPSTSVEDLDHTLAIEVAHEMQRNQSTASESVKPRKPKRAKEGAESTTAAQSEGVSTTIATGHMMLEKEEQEYQASCIEGPGSPASCQNSTTANKTIQQESGDGMGTTGNLPTSSRVLAASKPSKSSPKYAAVSATKPSYTRPPHPRVKCKFCNESPDGFRGDHELRRHMEREHSRLRKMFVIKDVSEDGQFLAKCKACQSGKKYGQDYNAAAHLRRQHFNHGTDEKKKKGSFNTSYPDMAELRKWMNEVEVVVDDGEYFTEELQATDVSKADNPRMGVNKESASANEGEEESISQVSNSESAVAENSPAPAVVIQDGELGVSDVPTQHQAPFDSTAWEEHDHWYESGGAFDLSHNYGVQFSVSSGSMPLADALNRQNNAAGEQDCMALPYMHLLQGRQDVQPSARGETASTIFGNLPGPAATKDTSGIFSATSLAMMIPGSESIFEADSLHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3S1</accession>
    <name>A0A2T7A3S1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3S1"/>
    <dbReference type="STRING" id="42251.A0A2T7A3S1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41304" checksum="DF8D9E9058D481EF" modified="2018-07-18" version="1">MDPLSVVSGIVGTVAVGAKVLMALREFGKGVKSAPEELKLLTRELEALHQIMDNFRKKTGGATVNEHTVSEKDGFLKKGWKQVKWHYIEKDIADLRVCLNSNKGNLLVALTLANELQNGHSYMKLERVQGALEEVIERLQDHDMQTVATCESFTLRRWQEVPSTPTIPNDQISVARSDSGIFSEAGFSVRSISMSAYQFNDMETRGKGFLISDGTHTKAYTVEARKQKEGLDSKQKEVGVPMAGSSGRSSKPPTKPTKPAPLNSIPEPEEEDEVPNAKDDSKLGGTHAKQLEVRQIQALAGSDRSIARLGDSLGMRGAIALAIPALEMYRHVARSAKDDSKLVMVSLFNIVSKHVSDRGLGGNACQAVGSPANPSSSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3V2</accession>
    <name>A0A2T7A3V2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_968382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3V2"/>
    <dbReference type="STRING" id="42251.A0A2T7A3V2"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="118" mass="13692" checksum="78A527E62250C3B2" modified="2018-07-18" version="1">MSIPNEALQKLMQEIEARAVFSQQQLQIVKSQMAAKQRDIRLLQLTSKELDTLPKSTKVYEGVGKMFVMEDLDSVLTRLDNEKKSAEGDIRDLQKKFTYLETTFEKAQDNLNQILNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4I2</accession>
    <name>A0A2T7A4I2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1061702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4I2"/>
    <dbReference type="STRING" id="42251.A0A2T7A4I2"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015502082" description="Kelch repeat protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="58695" checksum="F3E3B993507997EA" modified="2018-07-18" version="1">MARYPLLVTGSLLWLSGLVATVVNSTIYTIGGTAYYWTPKYTPGYQNADNNYSVYILKTSNSFLRALDLSKPVDFGAEFSDTADVISELPFEIPHVKLGAVWADQNKIYYWGGELEVEPVYMNGAFQNKTREWPDPMKYYTYDLSQPKGSGEWQTVSISMARGSDVLTVSPSFGSYTYSAEARKAFYLGGMFRRNELNNTDGSNATRAGIEPYYVGSMVVYDAVQNVWDNDTIATAMELNDVVDGAMVYVAGVGEKGILVRIGGIYTNGDLLSFDTVYVYDIAANIWHRQPTTSKTNIFPESRWGGFCAGAIAASDKTSFTIYIYGGYAHGQKKGTWALTMPYFQWIPVGSSGEPELGHSSTTCQVVGGTLVMVRGRGVWIHRGDTNGGSYFYDMTNLTWSFKYQPSEYQVPKTISDVIGGNGQGHATITGPTDDKSFAEGLGRLFTAAAANATRSTGSGSTGYSKGGSSNSTGAIAGGVVGGVAGLAIIWAGIWVLMGTHKGPPAPNYQEGWLARQEIDSVPIQIPVHELDNTVVQGGTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5B7</accession>
    <name>A0A2T7A5B7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_282805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5B7"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="805" mass="89224" checksum="6B00AF69224E7C92" modified="2018-07-18" version="1">MAMNWTGGTRNRATKISSTSRLQKRYFAKVRAAAQTFTIPSSQGNHPPNVFKRRRQTTPEFDIVVKKARSDHGEAIREAASPLLHIDKDSGKAGREVEEDIRKARRRMLLEREDWVCTTLSKPLVLKSKEEMRKLKANFHWEIIETSSSGATSSEDESDDDDGSGDSGILRNCSERGAASVPHESGRGIVPREGAPELPECPGDGEDIYIRIGGSTQRSATSAIDSTRTTESASRSTEINPTAIRGSSADTMLLDFDKHKPMFQFQHITPRVSDMVERKRREVRQSGYSSSPLARYSRQRGNRVPIPLDEGSGEVGEDDRLIQEVEQVSSPIPSSSTYSTIILQTGPGARERESLYPGTGETIEYDFPRIASMGGPVDEKISKEETLGHTRVTSVTFGPSQVSWSTSPAERRPCSYQREQSFDEIASEVIASENLLNLKPFVCSANGTQTRVEVTPDTDRDMHEVDEEDEEGTLDNNRTREIAEPKVEESETEMDQDDDSPGSNQNSSDPMSRDSNEDNMKDNQESTDYEWDEEDTTATHGATEEILGTIHVASTVAPEGTWAEIIGLITDGPTPPAQEDPIVAQDDPNQVEPSQTGHNLAECNNTQDSLGSAVDDQVFTHLEWLDKVLATSSDLFKSPEIHSTEHREYENREASADPVPNPPEPKTSKPPHPTPTKKKHGKYKRPARRFLIPPDEESEDNLRRVAPFRERERGHEIHCRQQQQQQQRKGLPHLSPENITSPIASPVALVYSKPYGLGFGLRERSVSAGDGAGEIRRNVGGKREGGGRGLVWEGEGGGVEDFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6W4</accession>
    <name>A0A2T7A6W4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1098620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6W4"/>
    <dbReference type="STRING" id="42251.A0A2T7A6W4"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="639" mass="72432" checksum="47E3DB61EBC1FAB8" modified="2018-07-18" version="1">MSRRLLPKPSTNPGDERRSLKPLERRMKRSCVASACMPCRKRRSKCDGKAPCASCVSNNQSQCVYDKQSDGRRAGALKRHINELSEDNSTFDCILGTIRSAPDEYVQPIITRLRSNEDYTDIANFIRENPFETPEPTTPTTSTQRSYSIALSADIGISETSTDYTEYAEGNQFLEKVFREAKGDIAEEDYLVNVQSWTSVTGDTEFIGHLLSLYFTWEHTYYALFSEKIFLEDLVCGRTDFCSKLLVNAVLSLACSFSDRTEARAETSDWGTRGDHFFAEALWLLDQENMIENISVTVIQALGVMGIREGGYSRDVKGLMYCSLAFRLASERGFCEGMNGDPRDPKVEVQRMTYWGSYCLDLAWSFVLARLPQLEGELLPLPMLQAGDSADKVGGGISSNEIDARPTGSTLFDQNFSQFIALSGIVRDITFAFYAPRQVFTVRKLHELFDRLKTWKVGQPLELQFAPRNRVPHSLWLHMYHRAAVIALFRPFLEVKIDNFAPSPKAICLETARELLAISDQFRNYHSWQRFPNTVPHFVFIACQTLLLDAQNEADGLVRGVETLLEMKNCWPIAELMLLMISIFAEKWEVDLPAEVQGHLDELSKDQLRATMAFSGWPPVRLEEEATWASFRHLSLSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6X4</accession>
    <name>A0A2T7A6X4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter NIPA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1072692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6X4"/>
    <dbReference type="STRING" id="42251.A0A2T7A6X4"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="288"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="611" mass="66581" checksum="DA0A2B9377630607" modified="2018-07-18" version="1">MFLGERLSFVGKIGCFMCIVGSIVIVINAPEQSSVNSIQDMKRFIISPGFLSYAGVVVLGCIGVVVWVAPKYGNKSMMVYISICSLIGGLSVVATQGLGAAVVKQASGTPQFNQWFLYVLLVFVIVTLLVEIVYLNKALNIFNAALVTPTYYVCFTSSTIVTSAILFRGFKGTPSSITTVVMGFLQICSGVVLLQLSKSAKDVPDTEIFRGDLDQVRFVAEQSEPESEPKADAIRGTAAIIRRISIARQKAEVEEARRIREEKINEMLNGPNQTMEWDGVRRRATLSVHGSPRRRYTMSGSHPPLGMSRMPDLEEGVESSAPATNMDPGRRRSMSVDEAMRTQVYGIQPDEPGQHPTGIVERVKSLFIPRQRSSPSLRSEAGVTTPHRDLRDSSGPLSARSYTSSEHPPPLPMVDMSASPGTPHLAVTPPAHEYSTNTRDFAPRPSSSSLRRTSGGSEYTALPSPATPPPSSTPDLLRPSSDSSSARRQFSFQNMFSRHGHTRSRSNPSIAPVEEPIATSPPHSHIHLPRLGLGSRGNSAPSAIRTEEEMLGLVKGDSRSNIPPYESDEEKEKAPVAGVRYVESDTDEEGEKGRENTRLKEWEAKTGLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7H5</accession>
    <name>A0A2T7A7H5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7H5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="67" mass="7609" checksum="68F6166C88AD3C36" modified="2018-07-18" version="1" fragment="single">MKPHLPSLTKTHHPLKQTPHSGCTAPPAAKLLPVFRRPKPPSENIFLSIHPQSLRPSAQTTRRHWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7K0</accession>
    <name>A0A2T7A7K0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_962714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7K0"/>
    <dbReference type="STRING" id="42251.A0A2T7A7K0"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015706985" description="Cupredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="64585" checksum="61354F4C778CE66C" modified="2018-07-18" version="1">MLLGFAVAVAAALLPFASAVAAPDVTTYYAGGAGPTATITADNQKVTSIDKSIKTTSYYCDKSGVYTPPHQTKVWSVYEPTWITYEVPIATAYIYPYKEAICSTCTKNVEVIVYINIDIIIYSGQIWKVIDGKTVTEIKTVTATPSYVSNYLPPSTTTPVGYAATHTVKVGGLNGTTPILRYNPEYVDAKVGDVVYFDILANNHTVTESTFDAPCVPKYGGVDSGFRPNMQNIPGTQTFPVTVTDDKPRWFYCAQPGNGKPHCQAGMVFAINAPKTGNTLEAFKKLAAAVPVSSTPSTTTSGTPSPTGGAAATYTVKVGGLDGTTPILKYNPEYVDVKVGTVVLFDILANNHTVTESTFDAPCVPKYGGVDSGFRPNMQNIPGTQTFPVTVTDDKPRWFYCAQPGNGKPHCQAGMVFAINAPKTGNTLEAFKKLAAAVPISSAPSKTTSGTPSPTGAAVPVSGAPSRTTPRSYSPAVTHSVKVGGLLGNVTVLKYDPEYVKANIGDVIRFDILAANHTVTESTFDAPCVPKYGGVDSGFRPNKENIPGAQLFTVNVLDDKPKWFYCAQPGNGMPHCQAGMVFAINPPAYGNTLEAFKEKAAKVPVKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7P2</accession>
    <name>A0A2T7A7P2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_788397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7P2"/>
    <dbReference type="STRING" id="42251.A0A2T7A7P2"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015719179" description="Extracellular protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="35415" checksum="AC87EEBEE8BA81D2" modified="2018-07-18" version="1">MAIRHSWLATPMFFFLLLWAASSAAHMTMSEPPPINYKTNPNYNVAKADFDYSAPLSPSGSNYPCKGHLKDLDAPEGKPVRTYAPGGTYDMIITGSAVHGGGSCQASLSYDKGKTFVVITSYIGNCPHATPGGDQTFKFTVPKAAPTGNAVFAWTWFNEIGNREMYMNCASVTIGSGGARSRAMAKRALSGPEVFKANIGNGCTTAAGTDVVFPNPGPNIQYGGNAAARAPPSGSCQEQNLSTVGGSGTSGGSGSGSGSGTGTGTGAGASGTSTSGSSGGTGSDTSGAGAGTMGGGAGGSGNTGPSSVQDSQGCAYWRSQGYVCSGAPKSLLGRKELLQMFGGILLVSVISGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7X5</accession>
    <name>A0A2T7A7X5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1038422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7X5"/>
    <dbReference type="STRING" id="42251.A0A2T7A7X5"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="67"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="19763" checksum="9299C3F7B5356F66" modified="2018-07-18" version="1">MTSETGLPENWTIRFSKSKNLPYYFNTKTTASQWEPPSDTDSDKLKVYMEEKFPAASIVPSEGSGPAGKIRCAHLLVKHKDSRRPSSWKEANVTRTKEDAMEIIQGFESRIRDGSTSLADLAAAESDCSSARKRGDLGFFGRGEMQKEFEEAAFALKPGEMSHAVETASGIHLIERLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A815</accession>
    <name>A0A2T7A815_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B9Z19DRAFT_1060642</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A815"/>
    <dbReference type="STRING" id="42251.A0A2T7A815"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000047">
        <property type="entry name" value="Sodium P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="845"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="875"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="24">
        <location>
            <begin position="44"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="25">
        <location>
            <begin position="699"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="PUU83881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="947" mass="102596" checksum="FA5672335DB0BDA6" modified="2018-07-18" version="1">MAASYGMLDFIEGSVITAVIILNIVIGFAQDYRAEKTMQSLHSLSAPIATVVRNNGRIEKVKAEEIVAGDIVCVSVGDVVPADLRLFEGMNFETNEALLTGESLPITKTPLLTLPHADYSLGDRTNMAYSSSTVSKGRAVGIVVATGMNSEVGRIAELLRGKKQDVGASFIARIWGKVKRIMKNVLGLVGTPLQVKLSKFALLLFGLAILLAIIVFSANKWDIDDEVLIYGICVAVAVIPESLIAVLTITMAVGTKTMAKGHVIVRKMQALEAVGGVTNICSDKTGTLTQGKMIARKAFIPGLDDVVSIQDTSSPFDPTSGIATIGGTIIDGGMVEKSKPLEQFLDAIALCNLSVVRRNDDVSMSSEKPTENWSASGEPTEIALQVLAMRFGHGKPSLIDSGNWDLLAEHPFDSTLKRMTVIYKNIHTNTVEAFMKGAGEVVVPNLNIPEEQKNAILNRVERLAGEGLRVLCIAQKTLPFGGKFGTNNRADVESQMNFLGLVGLYDPPRPETFEAVRKCKVAGVKVHMLTGDHIRTATAIAHEVGIISPAMPVAQAATMVMTAGQFDTLSEDEIDKLEALPLVIARCSPATKVRMVEALHRRRAFCVMTGDGVNDSPALKRADVGIAMGLSGSDVAKDASDLVLTDDNFASIVRAVEEGRRLFDNIQKFIMHLLISNISQVVLLLIGLAFSDRNGVSVFPLSPLEILWVNMITSSFLALGLGLEEAQPDIMLRPPHDLRQGVFTWEVITDKMIYGITMGALCLVSFVIVAYGHGGGDLGYDCNHAYNDSCTNVFRARATVFAVLSFLLLLTAWEVKHFSRSLFNLDPARHKGPLSIFHTLWYNQFLFWAVFAGFVITFPVIYIPTFNTVVFKHMAITWEWGVVLGCSAAYLTVVESWKGIKRWRGIGSGVFAKTGAQLEDGLEVASGVSSGRTSRSGTIVEAEERKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A884</accession>
    <name>A0A2T7A884_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CDC24 calponin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_961916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A884"/>
    <dbReference type="STRING" id="42251.A0A2T7A884"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="224"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="419"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="4">
        <location>
            <begin position="878"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="107733" checksum="517B87C3A2225574" modified="2018-07-18" version="1">MTVEIDQATLLRAQTAPAAMNGHPQVPMGTPSIMSSTTTLVSNNNGIASPTTSLMSTPVGNDSLINKKADPAQGLYQTCVALRERLMLVPDFERFLEPLPGAPEDPVSQLWRCFRMGSSLCVLFNAMRPVSLIEDSRCQLGLGSANDCKAATYHFLQGIKKELSIPDSESFMIHNLYSDDTNGFVKVTRTVSRILDELKGRNLLLNKKPSDPNRSSSERKPLDNRARVVQELVDTERKYVQDLETLQDYMRTLEADEVISKDLIHVLFLNLNQLVDFQRRFLIRVETQNDLLPEQQSWGALFVEYETFAVYQPYASNFKNAQDLAIEEKAKLEKKPHPVYDQLNAFLIKPIQRVTKYPLLLRDLIKQTDPLEAEEQGLHQGLEAIENINKKINEAIRKSENAEVVKDLEGRVEDWKGHKLEHFGELLLHGQFSVIKGDPKGDVEREYYIYLFERILLCCKEVGKDKKQNRAIGVGRPRPGKKRTMLQLKGRIFMQNVTDVISLAKGGSYTLRIFWKGDPGVESFVVRHPNEERLAQWNSMLQKQREVFTRAGTPGSRNGGRTSAGLRATATTEFAWMANSDTTDQGRRSEDERSEDEEDVEDSHDTATLIGTPSSGFNMSRNGSSTSLRSRAATNESLMQPPAPMGNLPGTYARPPPRYPQTSVPHQPPLTLNTGVSPISQSPERNASYFSPVTETPLTSRTSSSSSQFPFPRQTSAGYYEEPHRYGTPTMSRSTSREGAAIAASQAAQAQFAHHQASQRLQRPSLPGMAPSTSAATTLQQNRMRSASSPNIHHVPSQAQLARSPNGMTPPMPAVPSSYVAYSGGPAVINRSQNNSPTSPNLSVQGVPARNGSPAVQDGHHSKHNGNGTNGSSKSHSQVKLKVNFGNDKFVIIVPHNIAYVQLMDRIERKVKLCGSGPEITSATNLKVRYQDEDGDYISMNSDDDVLMAFDAPGEPGQNDSAGISGVVTLYVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A980</accession>
    <name>A0A2T7A980_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A980"/>
    <dbReference type="STRING" id="42251.A0A2T7A980"/>
    <dbReference type="OrthoDB" id="5578001at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="375" mass="41408" checksum="D6B2168ED54507C1" modified="2018-07-18" version="1">MVNFIPPPALSELLPPLLAHIPIAFTSPQPPPSLYPLLSPILRQRLRLLGVPSISAPSVEETWLSLLTWSSTAGPKLSAHLATQDFTPHPASGELELGEIDLKGFQRLDKETIKAYVQLPERSIEVVYLWIINDPDGEDDGWRIMDMHLSPDSEQTEWYPTVGEADEAFYSRSAKPVLPVANPIPSYSNDTLKIDNDDDDDYWDMYDRTPARTPMVPQKVDQMADDDYYSQYDNTQPALEPEGSSANSLPEHSRYTNPLMMQHSSSYSPTTTSSTPPTAVSTSFLIDKEALSGAVAHAPRPISAGSSASSAGGPADKLEEATSLNMQAETGVKQHISTSIKSLYRLSKSAGILREEFERLLQTEIAFLEMMDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A987</accession>
    <name>A0A2T7A987_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1070619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A987"/>
    <dbReference type="STRING" id="42251.A0A2T7A987"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="298" mass="32401" checksum="280F55C9AA04EBEF" modified="2018-07-18" version="1">MMDEAPSKASPAPTVETAAEDQAEAPQPRMSDHCTNDNPLDTSEVATGEIVKLADVDIYVSKPADVASGTARLVLLLTGGTGIMAKTNRIQADHFAQEGYFVVMPDLFNGDSAPNAAAVTAHTENADLLETIKFKAAEGVKGFMIDMWLARHTPENTMPIIEKVLRAVRETYADTAYDASMGVLAVGYCFGAKYVLRLAATDEIVAGVAAHGLLISKEDIAGVKKPVTLACVENDIFFPDEVRDEGRKQLQDNSIDHELRVYPGVPHGFAVYGSYSEEHIKTAQRQAFDQFLEFLNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9E0</accession>
    <name>A0A2T7A9E0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_2703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9E0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015730152" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11223" checksum="237CEC3DEFF32686" modified="2018-07-18" version="1">MTIEISILLSYLLLSPLSRLRTDHVTCCLHPSFPLATSIRYRSSHHGREFAHFRNRASATLCRAICSGNILRLEPTERERNKKRKQNVSFEVHCSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9Q8</accession>
    <name>A0A2T7A9Q8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1118034</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9Q8"/>
    <dbReference type="STRING" id="42251.A0A2T7A9Q8"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="51"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU84455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="292" mass="32871" checksum="F47311BBE4D89916" modified="2018-07-18" version="1">MYALRRREALKEAGITHVVSVLRLPLDKELFVQYQHKIVEVDDAENENLLEHFADTNKFISDALKSGGAVLIHCAMGKSRSATVLTAYLMASRRLAPHLALGIIKRVRPFVEPNSGFMQQLELYYQMEFAENIEDHPSYQRWVYLRDVEMSNAAGRAPERIHFRDARAEIGRITGVKEDETPEEKSGMQLKCKKCRIVLANSASFTPHMPKPAQPPHSETPKPPCAHHFVEPLLWMKTELSKGEISGKLECPKCKSKVGAYAWQGLKCSCGDWIVPGISMARGKVDEVSLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA27</accession>
    <name>A0A2T6ZA27_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1011143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000592">
        <property type="protein sequence ID" value="PUU72296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA27"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA27"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20545">
        <property type="entry name" value="CYCLIN_SpCG1C-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036580">
        <property type="entry name" value="Cyclin_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="42"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="155"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="41501" checksum="CCD54ABF824EF1F1" modified="2018-07-18" version="1">MSERQNLESQWIFTEEELLRTPSVLDGITPEVEREQRGKGCNFILQMGIQLKLPQLTLATASVFLHRFYMQNSLKKHHYYETAATALFVATKVEENMRKFGELVAACVRAAQKNHSLEVHRDDKEFWKWKDCILTKEDYLLESICFDLSIEAPYNLLLQYTNKLGVQTRQLIRTAWTFINDSTLTMLCLLYPSKTIAAAALYCAAKHCGTEFPDQDGKPWWEVIGVLIKDIKRACNYMAMVYEKNPLRGEDGVRYVATPENGAETTRTRARAVNGSSPPAESVSRSGTQSRSGSEGGKRTRDQTRTDEEISEEAVKKKLKLHEETVGNGVEVPENDSSIRGREKAPPPPPPPEKPENGELEEGEVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAH7</accession>
    <name>A0A2T6ZAH7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1168589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000518">
        <property type="protein sequence ID" value="PUU72501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAH7"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="9">
        <location>
            <begin position="243"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="447"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="688" mass="76037" checksum="5C5413DCB611AA41" modified="2018-07-18" version="1">MLGSETSRAQTHPFDSVPSQERRRPISSASQEAGWAGIPLVVTATQVDQRTVRIGISIHDGVYSVDTCINKVIAEDGEHLEDLIKKDANETIMLYSALHNAKFVGAGVTIALEKICPGICAYLWRELDNVGVKLRVQTEAISAFEDDGKVPVDVDEQADSAARKCAMYFGPTHNPDLAIAFRNRVGPDAEGAIRLVKGLGEYEATVHKGAWNTVLKYDSELKGYKNGQNQRDLQCPPTKIAFFSATPQGGGVALMRHALVRFCAELGLKLEWFVFISSIVHSYIPKPNPKAFRITKTNHNILQGVADPEARFDEDKQNLLNEWIGTKLTNAKRYWLTSGAPLAPGGADVVIIDDPQMPALIPIIKNDLVDRPGSPQEQVWRWMWDYIKQADVFISHPVDKFVPHDVPLAMVGLMPACTDWFWDLKFFHHDLRNSCNELGMNQLLYPAREYITQIARFDPGKGIPDVIESHRKLCTRVVKDTPQRHPPQLLLCGHGVTDDPDASIVFAETMELLAQPRYSAIAKDVVVMRIGPSDQILNALMTTAKLVVQLSLREGFEGKVSEALHHGKPVVATRAGGIPLQIQHGKSGFLVDVGDTDAVANHLFDLYTDDDLYAKMSDYAKASVSDEVVGTVDNAACWLYLAAKPARGQVFKPNGRWITDIAREEAGQRHELGEQILPHGGIDIKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAK1</accession>
    <name>A0A2T6ZAK1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="5">2.1.1.290</ecNumber>
            <ecNumber evidence="4">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_676106</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290" evidence="5"/>
    <dbReference type="EC" id="2.3.1.231" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000532">
        <property type="protein sequence ID" value="PUU72454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAK1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAK1"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="759"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU72454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="973" mass="108977" checksum="0D5EFCEAE7B115F0" modified="2018-07-18" version="1">MQAIEHVVRLFLFEELPDPKRKKIVINLGCGYDPLPFQFISSTRDLHNVLYIDLDYPDLIAIKSRVISKTPGLHNLLKNPELHDPPVDNVHYRSSQYLAAGCDLRELDKLKHILMDGGLINNAALLFTAEVSLAYMDQDAVDALIAWTGTLPDARFSILEQCLPSGPSHPFARTMLKHFSNLSTPLKSIEAYPTLTDQVSRFASGGWQTVDTLDLLAFWSSLVTDSQRKHLESVEPFDEWEEFFIFCQHYFITHARTGGAHQQDPGPFRAEGIIWSGGDYYSHPDLRPSLMRARSSEESRIESGYIGEFTSFPLLRRWMGAAAECGDNRWVYHGGLGSSTRLGTSLLITEDGHKDSLKCPKEHPALNRRGPSARMCHTLTQLAPEKLLLVGGRASPDVPMSDVWIVESGHWRKVESLPWGRYRHCATAVGREKVLICGGKGDGNVVLDEWFLWNGDNGWKQLAVDEERKPSPRFGASLCWTDKGYGVLSGGIDDKGQVLGDMWRLEIIDDSKLIVKWSFVNLLSTRSLLRRFGAKAIYLEEGRLLIIGGVSGGAPIKTEDEVVEIHCEKLTLRGIDIVYREPREKLPFLIGHQVLPASAGMICVVGGGGVCFSFGGRFNEGIWALIPPDVELPTREWKVWEEGEVLQKKPKMIPPTNLDNEAESTGEEESLMAEIRRVTIKSQEDFWRIRDAGEPVVIEGLGIGECVEKWTPSYLKAAVGPERWVIVHTSQAKSMSFHAKNFSYKNMTFGDFMDAITSESSPENLYLRSLSSSSPKTDPAKLAQDFPSLAEDFTIPPELQFAKDHEHSSPLRISAKEVGMWLHFDVMANLLCHIRGTKRFKVYPPTDITKLSFPPSASSSTIENPFDPELEPDGVRPMETILRPGDVLFIPELWPHAAYPLEPCVAVNVFFKSLEHGYSSGKDVYGNRDLAAYEKGRTMVGRISKGFERLPSAARRFYMERLADELANMATDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAM0</accession>
    <name>A0A2T6ZAM0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_659844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000512">
        <property type="protein sequence ID" value="PUU72538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAM0"/>
    <dbReference type="OrthoDB" id="5351958at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="311" mass="34608" checksum="05A81079CD8FD61B" modified="2018-07-18" version="1">MQSLSQMFSLSEFMTRTARSSKRSGLPVRPPSGSPSEPRTSIVHEGALIAGVMKVTVRLRGDFGGMVHTTSVTFHAFDGLGRQIDAALNRHFGAGAVGIASPTGKVITEDYQLYQLRYPGYSYTFCNVVYDRGYENQHPPITIPSQRILLEVADDDIAIDGGERIRYVNPAFNYSTTYMDHAGLSVTKPEQHEYQKQLAIQRGDYYVPHSELPSYECVPPRKLGRGVGDACFACVCCRSWIAHFLEEYGGQALETMASRGPSNSRSARRRVLASHRVMYGHDRPLRARDFDGLSLEQRRTLVRARGNAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAT6</accession>
    <name>A0A2T6ZAT6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1096924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000498">
        <property type="protein sequence ID" value="PUU72595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAT6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="69" mass="7936" checksum="F71A5FD3A8EC602B" modified="2018-07-18" version="1">MVPKRLVHVLDRTNQNSIAQWQAIRLIPATITSLTKVQPIVLLEPACGWLYSGIPHWHFLWSIFSSLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAV7</accession>
    <name>A0A2T6ZAV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_646819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000494">
        <property type="protein sequence ID" value="PUU72632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAV7"/>
    <dbReference type="OrthoDB" id="5401727at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="465" mass="49979" checksum="7B37D5296F75277B" modified="2018-07-18" version="1">MSSVLVSWGLFLAIAFAGYWWYGGSGKAQPHGKRIVLTSSEKLSGGSVFVSSGTDGNTAEKKKKPKKKKTALSNTAPKKVASHEDGEKVVQSTDDDVARDEDELQALRRLQSLTTESGGKKGVSSSSSAKQSQSQKSQLQKPYLTTPASPFATASQTSSTGADADIDEEETSQLPGSGFQQSTSTDPSDMLEGFTSGARVLTITPSTQPPRTQKQRSTTPASQSGTHANKNAKKKEKKKLEKEAERADQKARFEQHRASVRAAEAAKQKSKPPSDDPMVGSAWITVNGKRSSTPTNALEVEPTSGDLLDTFASPDTQANTQHISDNSEEEKNLTKSQDLTQRQEINDSLWETVPAYLAADWSEVQRKGRKQKKAINNPDTGKSGDESASVESTKVSHQPNPERPTASKKEGFKKETSKAGTSESTKSGNGFQLLDTGSTTSDTKNSSSDWAEVDDSDNWAVHTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB46</accession>
    <name>A0A2T6ZB46_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1167090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000477">
        <property type="protein sequence ID" value="PUU72718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB46"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="261" mass="28563" checksum="8C1B37EB5B682CD6" modified="2018-07-18" version="1">MKMLLRRKDVIPSTVDKGGRTPLSWAAQHGIKDMVKTVLKWKDIAPDTADEGGRTPLSWAAGNGNGCNVKMLLKREDVTPDTADKDGRTPLSWAVENGDWDTVKMLLKRKDVSPDTADKDGRTPPWYIKSQNQSFLRSRNLLRSRSRNLRGLFWEREHVAPDTTGKGGQAPPPCAEERRPVGVVGMLPERCTVGQDTVVTDLTDQTALTQTSQTQHGAAIKQGLKDQDSVPQAAGSSSSTDLPPSCVPRAIQHPSKRIGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB51</accession>
    <name>A0A2T6ZB51_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LUC7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1117697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000492">
        <property type="protein sequence ID" value="PUU72644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB51"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB51"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32891" checksum="A19145C458961C44" modified="2018-07-18" version="1">MAAEQRRLLEQLMGTPNQTNSSVPFTDPSVCRSFLVGTCPHDLFTNTKQDLGPCKKTHLESHKADYERERANKASKDLGYEYDYQRDLQRYIDECNRRIDAAQRRLDKTPDEITKTNSLLKGIADLDGSISSGLQEVEVLGETGAIGRALDEWHKVKVAKMEKEGKEKELKLLSDSAGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYAQMRATLKRLQEELAGRGPPQGQHGRDFRDNDRGFHDGGYSREQSGGGGYRGGFRGGRGGGYRGGRSGDGGGGGSGGGGGHRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBC6</accession>
    <name>A0A2T6ZBC6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1008112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000465">
        <property type="protein sequence ID" value="PUU72791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBC6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBC6"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60364" checksum="53482CA54FA50C74" modified="2018-07-18" version="1">MPTRVFSTDETFNAFGHWLISHGAFIHESLTFTPSDSQFGSRMITSSDIPSHSQLISCPHALAIDYKKAISAFSADFISNTTQHATLCMFLCLEWLKGKESLWWPYLRVLPREFDTPLYFSDEDLKYLQGCNLDVNEVEARKLMWRQEFEAAVTILQREGYNTEHCAWELYLWASTVFTSRSFPGKLMNWDREIDHEDDTMPILFPLIDSLNHFPITKITWQPSDTSLKIISGAEVSTGAEVYNNYGPKPNEELLMGYGFTLLQNPFDSVLLKSSPALTPPQHSLLGESPTGLYHLTPRNRTPENPSIYPPALLTLIYVLTSTPTEASRMPTRPTKPATKRNEISTHMTLLHALLRKLQNFPPTLPEPQNSKQASAKIYADSQRSLILSAIAESKDIINSHATTSGLIRLQSTLRRGGGTDRAFAAAIESCFGSADVEELTESGQEDVVFILHLCHLSLTEQGFHLPAYPTDSQEATQSARELHGELFPAIANAAPAVFGGEGWTLELLHRCMEAYADTGIRFPEIEGLTLAGEYVVCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBG3</accession>
    <name>A0A2T6ZBG3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1117610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000457">
        <property type="protein sequence ID" value="PUU72831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBG3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBG3"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015711239" evidence="8">
        <location>
            <begin position="32"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU72831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="498" mass="54886" checksum="959414CDAB52CCD9" modified="2018-07-18" version="1">MKALTATIKRRTDIYLLPFLSLLFLLNSLDRSNVGNAETAGFTHHAGLAPEDLNDAVSAFFVAFVVLQPVGAALGKRVGVGRWVGGVMVGWGILTGLNAFVQSRAQLIGLRACIGALEAGFYPATVFYLSLFYTRYEFAQRLGMFYGQYAVAGAFGGLISYFVFKLFPSDPESDIRTPPAQQPEHEGWYNYQILFLLEAGLTIIVAFTAFFWLPTGPKNAWWLKTPAERAWAERRVLIDRAQAENVLEEEEEGEELLAENESDNEGAKRRQRRGTNGDGKAIIGGEPGLNKQDITDAITDWRVWWLLVCNITSSVPGIAFSIFLPLVVKGFGFSTLHANLLTVPPFLCGACSLWCTTYLSDRSRLRFKYILYGLTLSLSSLALLVLLPLTALTPRYFSLCLLLSGTYIASPLTVAWLSNNMETPGKRAVVLGINGWGNAAGVLASWIFRPEWAPGYERSFGWTMGSVGVAWVGYALFWAAIRGGNGRRRRMGLVLVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBQ7</accession>
    <name>A0A2T6ZBQ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1136378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000444">
        <property type="protein sequence ID" value="PUU72913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBQ7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="34113" checksum="D81FA2659D5974D0" modified="2018-07-18" version="1">MFRKTPELVPAGGQTTGGIGPSEGGEGRGDGGPSHERSGAGSPVRRSVSPQKRLYDESEVDPKGKKKQRSEVICEDNHAHSSGEDDYFVCLVPTTSSSCLAKVATFKGLKSHIRSTHLESLTCPIGECEFVTHNSKDLYKHHMDDHHGDTFQGAVFRTLNHSRYEDKEALKSAKNMDQIFEIFSRQEGEIPAAGPSGQSGSVGAGSDGGDEGEVHGVDPAEQYGRDYGVGDEGDHGVGNGESEEEGDGDGEGDGEEQVPWGAAEGFMASHFADFAQTCTEDLRRQYGTAPRSPAEMEEIFQDLGRFFSAIALAARDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC65</accession>
    <name>A0A2T6ZC65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000417">
        <property type="protein sequence ID" value="PUU73073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC65"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015549820" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="12838" checksum="C47882958D3D9FB4" modified="2018-07-18" version="1">MSSGQLCTVLVLGHSMHLTFLFHFAHARLSLSNNSSPILCTLLSFFNANQRSYLFSLGIAMGEKSTKEEPNLPTKIRCLAFNFRGKRRKKGTHWSNNSDEPPFSFLPFSYHGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCC5</accession>
    <name>A0A2T6ZCC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mus7/MMS22 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000413">
        <property type="protein sequence ID" value="PUU73096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCC5"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2210"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2214"/>
            <end position="2223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2238" mass="250632" checksum="3512660E22A325AF" modified="2018-07-18" version="1">MTNWRETGYVPASDGDISESELSTQEGLLGLPEPARITEFKSDDRAHGSATNQTGKVQEEAAGNSEERDMAMNDLVVEDDLPGCPSGIGKPEKDVGGIGLGSQHGERELLERDPLEQTHEAGEKLISQRKLGCVDGRKDLDEVSVVDLSAPDLEERDEFLLETGAMDSEEDEAMLNLNSYEENQAHATPQPRTPPNPSWENSAATSSPLSSPPSVVLTPPSIAATRSPPRRVGFSVVIPAIEGREEEEIVIPPDDDAPQYYRSLRARKPIQKNPYLIEQERYRQTLKARGVRPVRISEVEEETNGGHGADEDSQERDYVAPLEPENDESQFVPVPSSRRDRPGGQDDRSVDIYDFEEFPGAASTSRERPRPNGALADGVKRRKVNHTHSKRPYANAARPQLNGGQSTGTTHLTPSSIQAEVDEEGRDVYELPEDSPQRQSRTPLAQTSPNGSPTKKTPQKPAQEQGIKRGGILSLLDSSSDIESTSGGRGGPWLISPESEDGDTPQARPMRTVLELPSSSPEESIPSESEDESQVRRLQRKTAGVLPASWWKLDKRQHPSSANDSRRDRRSLTPVQDSTPRPGVARARITSRPRSPVGDVFLFGDDSDDSSGPANIQPQVPPSGRPRLLHRQHQIEVIEIDDVIEDDRVDRMLPVARRDRGPTKRRQKDQNGLPQAPRGMGAGGPSAARNPGSGSRLQQPRITNHIGTKRKSTKRKPKAPQLGIVDALRHHRATNPEISPPAFLKVATRSARGRRSRGRQSPSKKVFQLDTIADTQEVQSVLREWREGTIAIRAHDSSDGDPTNDAPPTRSLPPTIDQRPAGVMGLDLGLSSVGASPSRRPRPRQATLTNITRIRPLLSRINDAHRSRQKSQKRLNTTAMPARQNTITHRPFFMPEPAQFEREEPPSVVAARLRKTSRQGQRLNLAELLRTTARKHRNLGRFMDNEDMMNPPPIMRSGPGPAPTPIPKAMKPSRSRRKRTPMRIDAETIERRQPPPEDRIIADDAEIESISEPAPNTTLDDKPVLVGLLPYGSKYTLSFDTIPLKPGTIFSSETFVGNGGLSRALNSKLQAFSHSSSFRFGDKLVRWGVYEDCIAAEFESIMQDILGFVERAHEGGGDVEAHVWASRAYSFHVFFSNYLSQVISFSDSIDLISFGQRILQAINASCDQVLPVLGGSTPLSLSKASARLALQLHVFGLLFAFQIYKLASGDLEARERLDLNRTIRRLGHQLLGRLLRCGTDAIRECYEDQRVIANYERGIDLKHYLIEAWVIAIYTLDSVHCQDISFWQLLNNELRPLEIERTLDIRIFEKHWRRVWTILPLYQFDEFGVVQGLVRDGNLSENWALLRVLWGWLNTDIIIPVLYEFFASKNLANLRNEETYGSPDFLQNLDRNPSLQMLDSDPCFHLLLKIVGLGLHAMKESTPIKKIGNLVNRLMPNHGHQYPKDKELRVENLTALRNHHDLLSTLWWASPPRCRPPLEAIWYLVDPDLSHQQACIVSIRAWLNLMRFQLHSGEGLDILRPFMEWFDRFTSSALNQHHAARSEAEKHFSTAMERGDTELSKDIMEDTIRRNQQQLEGILIDALKSLRSLLVGIKGQTQSAIVILTKASTANILNSYGRLSNRLIFEALDLIQQYLVVAKSADESAGVPVQASEDSQDYGDWSGFDDIMIRDDQKAAAEQLSVTVYEALHRMLSSCFGNDIQPEDSLLIKTVDTWALVVGFLVRHGLKNWDAYLDQYNPESWSSLRDTEQTRKFTAYFIPKVIQSGPDVYESNKTTFISFWLKTLVERESLLKFQNEYTATLLNCDPTNPILANLPFIRDELSGEFKITLTDFRARRLSLISTTLANMRENYEEAHHDSAQRALALRLEYSEMLKSMMRSMKEIYQVLYLHTDAHIILTSKQEIHAKSTSGAYVEFVQQVVEYLQQHSIDIVTIDRFFTDESMFPLPSADPTYVVGRLKNYGLKLSHQRMHTQLTSFFQSVCERAAIDGQQEYLVHQLTAALSGELEVGTVQKPSLRSLFMEAIFPAYIECTFTNPAGWILSAPLLQATEKILAKFRLDVDSTLDACVQAVTSMLTTLLNSIHASLSALPTPDILPSSINTAIYTLFLKILIRAIPLLDTISPTPHHPAYETAKSITTHAAVILQHISNPTVPLLPLPPLPPSPPLTPHISTKSATIATLTKTLRTEWKIHNGIWKNSTQVYNPSIRNIIHHGPSPSTTHSLTNRPRPLRKQAFTESMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD29</accession>
    <name>A0A2T6ZD29_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1135206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000379">
        <property type="protein sequence ID" value="PUU73400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD29"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD29"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003011">
        <property type="entry name" value="Cell_cycle_checkpoint_Rad1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01246">
        <property type="entry name" value="RAD1REPAIR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="550" mass="59454" checksum="466F5D2FAA4E477B" modified="2018-07-18" version="1">MAAIRTLKAMPSHQTRYPPAERRDPRGGESIPLSTSHPGLSFGTPQRVRADLGGNYSINPMNGLYPSKAQSVVIRLCYVGDLRSLEVISDTEYPPFILDEKRSLVIKFDLGNCTALTATDIKTRDPTNNCSTHRSHPLAPPPLCPEPQECIATTNIPPNPEVTHGEYVYLIHRQKVVSMHYSKDRALSEIQAIDANVQRAAGMLGLHDISRELADGLVDSARRKLRFASDPTDEVLTNWHYEELNYSAFVAPPDEALLEKCGLAESDADSQSEAEDGMHEARKICRDMWARTYGPGGGGSIQRMKFSTGVNRKGGANVGGTGRAFIDKNLFTTYTFNPPPHLTQNLEDDEDPVIQFGISLTALLECLQIFDEGDAGGGGGKWRGGGGRAGGGGGDSWSGGAAGLPTTTTCELTTHLSTPLLDIPSNANPENHPKILPSSSSLLVVSTSPTPPHFTLPSTSPLGTTIVEFSNDGALLETFTVSRRAKDVYRFALVRHARGAMAAATKFMVEREGRVSFVDFRFLRAGDREGGGGGRGDSAEEEEEDKDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD40</accession>
    <name>A0A2T6ZD40_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1069048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000383">
        <property type="protein sequence ID" value="PUU73366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD40"/>
    <dbReference type="OrthoDB" id="5419378at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015700706" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="47449" checksum="4637EC140CBC4B26" modified="2018-07-18" version="1">MFLRRCWSYILFSHLISLLASAAEIGYGPLFDPCGDNCQTQMVNFCTVGRDLAQMTDCWCGDGEREYIGRMDACLSTCDQAVSNRSVQRDQMVRYRKIVCEGQRGKTVIADTLFAEYWKTRFQRKGETFVPDVTNGIPPPTAEPVGITSGDDQVSRSEFISSSPTGIPETYSSLESNETGSLVSPSLTPPPVSSATAILSSLSSVSVIIPTSSSNFTTTRGTPAPSTLSSFPNGSRLTPGQLAAIIASCVLGSFLLVLSIIFCRRRHANSKPFAFLPTRPGSYPRPRLITNHQQSWWSRNIEAALNNPQSPIASILPRYYRPKPRTPPSAQQNFPPPVRQKHSNTIIPVPPSSRSSSTRILTLSTTTRSRSRDRISEHTIIEPQPQVAVTEVSTTTRQSAASSQCDYRYSSATCSSWSERSWVENDDPGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD90</accession>
    <name>A0A2T6ZD90_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1135148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000376">
        <property type="protein sequence ID" value="PUU73443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD90"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="9172" checksum="E1A8ED85FA05B150" modified="2018-07-18" version="1">MLLPSRDHPKRKERKMYEREAVELNGVSSTSRKKLWDKLSSNSATGHYRDIASPVSARWSSIQPKLNGLCPLSSNSNEENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDA3</accession>
    <name>A0A2T6ZDA3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1135115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDA3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="351" mass="38990" checksum="218D0763E6CF9DEC" modified="2018-07-18" version="1">MNPGPHIRDEDGRRTEGEKLHQQFNKIVTCPSCKQGNAIKGTFIKGSAGNADKDGRRYRRFVCRPSGGCGASIGVTEFIKLCDKQKLVMAKDISTNMDPLSQIPTTTVTENYKESRNSHIPNASRMMAIPIDNTHFTATYEESRIPTSESESELQYHNWETGNLQPVTSRIQKLQTRLQDESVQRQRLEARISALENLIQEAGLQAKSQVLNPILVNQKRNSNMMLDSASDQSEEMETILNPHTCSSRETDHDVELAMHESPSTTASGHSIPTHTYIDKGKRPAYSVVARGPALVQARFKSTTIGMAQEIPTQSNVQSSRHHPTNPVGKNDSRNSASTPLYLAGVPNRRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDT0</accession>
    <name>A0A2T6ZDT0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1134755</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000357">
        <property type="protein sequence ID" value="PUU73650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDT0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDT0"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="393" mass="45119" checksum="07C6A1FCD9D5D3CA" modified="2018-07-18" version="1">MSQNRPAAFSGLRMGEIIREKVQDGLTGEIREMQYTQCKIVGNGSFGVVFQTKLSPNGDDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERKDEVYLNLVLEFVPETVYRASRYFNKLKTTMPILEVKLYIYQLFRSLAYIHSQGICHRDIKPQNLLLDPASGVLKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTPKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTRDQIRTMNPNYMEHKFPQIKPHPFSKVFRKASPEAIDLISRLLEYTPTQRLSAIEAMCHPFFDELRDPNTKLPDSRGGQGLRDLPRLFDFSRHELSIMPELNERLVPQHARPALLSRGIDLNNFVPMSKEEMMAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEH5</accession>
    <name>A0A2T6ZEH5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000340">
        <property type="protein sequence ID" value="PUU73846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEH5"/>
    <dbReference type="OrthoDB" id="5413994at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24495" checksum="AD90A729F6270E4A" modified="2018-07-18" version="1">MAEAVEPLPSPPDTSPIATSASARTALSSPNTTQRDRVDIASSPSSSRAAPPIPTFASLAQSFRDPSELNSHLLSLSKAELAAIIVSEAGKSSTTTTTTKSPTPESKKYAHCVYCHEIFDKEHNVGCQVMHYGEIEEIDDDISQLTCCGLSLDYTDFDSNIGMPPEEEEPYCYEGGHWDRFIDQDDDEEGTWWQEWGNSGRTCKDIGCQGMVNPKKRRYKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEJ7</accession>
    <name>A0A2T6ZEJ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000337">
        <property type="protein sequence ID" value="PUU73866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEJ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEJ7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="21139" checksum="D8DA060994C0F8BF" modified="2018-07-18" version="1">MYASGAPSLASTAVTKFIEEYFLDMELILSPERFQFSQVCFCLHHYCGNRPTFDIADTMWRILRALELDLAMSKECDLDSVFQYWHDKNIYFKWVRMMAMEVKPQLMDMRQSSMHTALIHKWGLSSCFHAHRSRFRTSFVEDGLFRSYLPKKILEPCLTELPEELESSPLGDGAAIKGYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEP9</accession>
    <name>A0A2T6ZEP9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000337">
        <property type="protein sequence ID" value="PUU73874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEP9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="263" mass="28334" checksum="E3112AB9BF115CE8" modified="2018-07-18" version="1">MLVFFPTSIKVLLNPNQAIRAVPKHSLPLMVSSKHERSATCSAAQSLRKEVLAHAEDIRGVITEEELLALSAPHGNIIYDLVTKVDREYLIQRLTILSKSYSLANKGVCTIVLPWLVPDTNPSSSHKPMSPPAEDEITMSPPTTVTIHTTAQPNPAEGTSASPTPAFSIATSAHPDNIGQKTTACEDRSLVDMVIDLVEKYGKHMRMGTGERIGNQASRILAQGLPEHVLRFIATVYQDRIASEGDATGIGAQTEGKGKGTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEW8</accession>
    <name>A0A2T6ZEW8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein-coupled glucose receptor regulating Gpa2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1056857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000326">
        <property type="protein sequence ID" value="PUU74047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEW8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEW8"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="328" mass="36777" checksum="66D604B59D782768" modified="2018-07-18" version="1">MRLAICVTTLIGSLLSALGSGFICLCYLLLPLKPHFRHRLIQSLAIADFLNATSNAASGIYILARDRELPEGIACRMNGLVTQITVQATDLSILAIAIVTVWVVTNPGTFGAWSTRKAVLAVCFIWVLPFITGFTALGKDWYHPVSGNWCWIQKKPVYLRYALTHGWRFFVIISVIVMYTYLHFFLRSHYKELRDAAGDLHADAGALTVDLSNSHSADEKYENDENDKRKTHTQKPSHRDPDYGGEVKKVFLMRAYPFFYVILLIPGIANRMVEASGRSSKVTQLLQASTQFVGLANAITYGWNEKILGELRERFGRRPKPSPGSHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFE8</accession>
    <name>A0A2T6ZFE8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1110780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000314">
        <property type="protein sequence ID" value="PUU74220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5367096at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="826"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1471"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1612"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1202"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2231" mass="236879" checksum="CFD68868650B5F90" modified="2018-07-18" version="1">MQDEQTSQKPIEQQKARTHSNCHYQWLLEEKFNMMRLGFLTKKQNQRLVFWVGKVSEAVRSGPVPRSELDVCLRPVGSPLPSLAIVSGWTETYEKMLSDTRFWIRAGNGNIRKVFLLRWSKTPLHEVGCDLEVYEWDKSTRRERFSQHEVVLPENEDLDELQIVTVLFSEIFGKKFPDTDPNSSYIFSLGRLRAIAKKVIEEDGYGLRTVASGPKATGEVALAGANNSIFQEPSPFPPPSYILGQVNQLQLQLPVPPATVGTGDFEQGVPGPEQAPSMPVANNSLDPISVGAGPAEPGEVGGLPAPTTLPAPGIGVLPDGKHLDASQLPTSPRDTSIPLEDEENPNGANPLHSSDPDPGAAPHIATSPTPDGLNKPIDTKSPGCGSPFSDPPLELPEPTREVPNPSGLEPLGSAGCQTSQPGVLNPPPGGGGIPTPSLVNTELPIRPEPPEEDSPSKDPKDLADQIGNPWGTRRNNTEGKTLEQVLGKDTPSESPEDGANPSMTHVPDHTDKGADVGPESSPTAGSDKTPVIAGPAPKKLEGGVPAEAHPTSGSVKQNNDTSSPCGPNELGSPSGNSATPAEAEGVEKIDPESSGLGGPSSSILTPQTEGSENASNNPLPNGARIVVEQPTVDAHVTSSDEPNAQTISRNVNQELDATKDIPNKKVSESIADSPGKTELSLHDSTPTGVGSVDSPGLLCGGGGAGANPEPLGRASAFPRLLEDPHTPKAPEDTRAAGVGGSVHDLDTTPNILGKWSPLLKSSQDSDVSDSSYTSGISDISDISDAKVNKDTNTLQETDPIINKVDSEFEEASPSLDIDILEALKDNDAVSGVDPVDGPKSRSEPPEKNIGSFESPLNPAQDSDLLKAASDVEPSQEKDLVDSLDANSGSLLDEGLQPIQPTGSNILGAVDRSGSIEELDPISNPNTDIDPESPEEVNAPQARSAGIGDPEALGNSENTAGVTDPEAGSDPSEEASSALESLQPSDVSKVAQAADSTQQIDKTDTLRVGLDHPEGIVPAAAPLQDSIAPVVGNAVRDGALVLVDGATSTGESRRDMVSPKLLPSPATESTSQDAAPEGGSVLEDIENLETVDTLRVEPDHSEEISPAAAPLQDSITPVVENVVRDGASVLLDGATSTDRGLPPGDTVSPKLPPGPATESTSQDATLEGGSILKDIETPETVDLEEGEGIFVDTEEGFKAPGAQRREETKDLDHENLTAVELQAGGISLLDPLGLTTGDDRGISSNDGTGISIPAEGLENVPRTSSTASIATSLRKWDPGEFFDTSSDTSENNPGSTEIPGFLGTRDRTMLSEPLDAPHSHQIDLLKSPEITTPSQSASAKIDENPDLSGIACKKEESTRFQSHVVAVKSDVDSQKGTQEADEAELQKMEMGSVGYFTAAALPPTPQPDRPVPECSKCSQAAVLGRSEHGSNQYAPAGNPKSLEGEGSPRSKVDIQSNRRLSISSAFSFVSSLWGKSASPTPPATPPQASNTEVHEAADTVATPQEAAPAIKTPGSQRPAGQGERKVSWDDIVGGGRRGRSESSGSPEESSPDHLFLPPATAVGNSIAGEGPYAGDPLGIGVQLGDNVYSLMSTEVHTSGHSASDQRVIKAKANSLTRTSPASEHYEEPPSADTGDEVAQIAVASYCRRTSDETEDKESLVASPRPRTRAVNRAVAASPIKSPFPTSMFPWSDSQRIPFAAPSTARGGAPTPAIGPLGECSYARSPAVGRTPRVGAESPCLLGQASCVHASNSIRSLGPTPTTTDPNGSARCIHSGSPPTDFRPVGGRLAPLPGISGASVRGMQSGRYQSAIQEEGEGFAHSSVDESDRISPERFSRLEHLIKRFAQEHFSQLPPSLRVFESSASLSRSLFPPEFLCTSSLGKRLRIAAVQNIICRHLVNSIFSATVPSFCFNMEAIAGELMKLDPLKQALWQALTVEALEALPQYEMAAAKLRQRTVNEILVSIGAISASPAATLTESLQNLVKSAQEAWEPTFKSKAQTIPEVDVENGTANFKMDPEDSLVRESFGLQAESIARPVLCLFPAIYQIIDGHDILVAPGRALFSDLYHSAEMELQARLDTWNSDQKYARRASFMRPPFVPHNTHPLASPEPESGRWSTRRMSHEYFGHNQWCSHPNDFEDEAIDFWDVSRRLKEYDQEVLRHERGRSAGSETFSERRSSYVSRSRSFSSGRRESVYARQESVYERRVPMGGRRESFYGGRRESFRGSRDHCGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFP6</accession>
    <name>A0A2T6ZFP6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1056423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFP6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFP6"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="247"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="551" mass="59353" checksum="A97F318010B62F59" modified="2018-07-18" version="1">MSSKSSIEPWALTRLKPLLPLPEDSLKEVISYALSLADAGEVGSHFEGLLGSAEDVLNFISDFNSRLFPQRAARAPTIARTSSPASSSVDAPPAKRRGKKGKPPINQYANQPRQVEGQFSNPAAVYMKKDIEDEYYTGSGKGPTLRLADSSSPSSSAPVSRVATPIPRSSAPQLVQQKAQHNSSSNVGGKLVSDLINVKAKVKKAPQKVHVTGGVAMRGASAELTDLESALRALELSTNPTLTSRSQKCDCAGMKHEVLSAAPNCLSCGKIICIKEGLAPCSFCNTPLISPRELQSMVRELREESGREKMAMHSAAHKRPEVARAPKPFSNYDSTPGTSDDEGLKKATEHRDRLLGFQATSAQRTKIIDQAADFETPSTGGNMWATPQERALQLKKQQKAMREMEWNAKEDYEKRRVVVAIDLEGRQVVRKMEEIKPREDSDEGDLGKEAYDSTLERGGAAAATSSSTSKGGTYSRNPLLKGMIKPVYDSGKGKGKEGEGRKLDTEPKAYAGGSHGWRRVQDDFADNEGVILGAGIGGEERGTQGEEPACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG02</accession>
    <name>A0A2T6ZG02_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1092897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000300">
        <property type="protein sequence ID" value="PUU74428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG02"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG02"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF5">
        <property type="entry name" value="RCC DOMAIN-CONTAINING PROTEIN ATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="159"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="252"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU74428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="346" mass="37022" checksum="90C920E721E7AC8E" modified="2018-07-18" version="1">MLYAFGSNGRGQLSLGHLEDAHTPAPCLIPSLFPSVPPREIAAGGNHTVLLFPSGECFFAGDNTENQCCLPSTIFPSLTSFHPLSSDHRWEHVSAGWSFTILVDYEGKIFVSGNGQKGELGLGEELRDALLEEIIDFSPGKVIQIASGMAHTLLLTASGDVWGWGAGRKGQLGEPTQSIVPRPRKVEVGFPVSKLDCGKDFSILVNRDNPQHMEILGNDRYRIGPSLASWSGTGILDVQASWNGVYLLETSGTIKAWGKNDRGQLPPPNLDGITSIAVGSEHALAIAEDKTTKERKIITWGWGEHGNCGKSGGGDVIGEVFTLDISAPENVRIGAGCATSFVWMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGD7</accession>
    <name>A0A2T6ZGD7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1157993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000292">
        <property type="protein sequence ID" value="PUU74560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGD7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGD7"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="104" mass="11973" checksum="05574FFA5F2D0450" modified="2018-07-18" version="1">MALEPDEDRYGMFEAGHIFPLALVDYWDAYEFEIDEDQVNAPSPHASNHPINSSLNGMLFRRDAHYLFDTYQLSINPEDNYKITALTREAAEYIPTLSRPPKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGI2</accession>
    <name>A0A2T6ZGI2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1133063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000290">
        <property type="protein sequence ID" value="PUU74582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGI2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8775" checksum="6E72D104AF72E018" modified="2018-07-18" version="1">MAKVPKGTKLKFEIFRKLKSHSVKAIQNRASVLVENIFKHFQTLPNASSSLKGAGKEYQEREYKDFGYTKENSGVCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGJ7</accession>
    <name>A0A2T6ZGJ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000287">
        <property type="protein sequence ID" value="PUU74618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGJ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGJ7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="244" mass="28118" checksum="59330CA70513920D" modified="2018-07-18" version="1">MVGKGEKSGRRGGPGNLGARVEKKERGKGGKLLLEDRKYRVVGGGEAVLGGCEGDWKVYKGLKRVEGGWENNEVRLEDEMVLDGSEWGISGKGDWNIWEDDMEGVEEGGMNSAEAVEEIIKGMRGDKDGVEIKKEEVEKEVKEEKKEREGNKRTEKNEEEEENECCREKKRCREKEVEVVVVEEDEEEGLSSMEKWAVEKKAKERREKEERKRREKEGIVNRGKDRGMGRDSVMEMWKEWQDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHA9</accession>
    <name>A0A2T6ZHA9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="5">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnxG</name>
        <name evidence="6" type="ORF">B9Z19DRAFT_1132590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000273">
        <property type="protein sequence ID" value="PUU74794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHA9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHA9"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="127" mass="14061" checksum="C5BEACB59231B962" modified="2018-07-18" version="1">MTAEDENSLISPEFFGQYSGVADDIHSTSRQVLSMAENNPTPTGTFKILYFAYASSHTKKSEELLPAPMQLSELFETLDKKYPRMKEKVLGSCMVTVNLEYVDMDTSEEKELKAGDEVGIIPPVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHF1</accession>
    <name>A0A2T6ZHF1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1091536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHF1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHF1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="576"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="714"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="665"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU74915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="757" mass="81797" checksum="0ADDCD7662695998" modified="2018-07-18" version="1">MGNGRGRGRGGRGGRGPRGNRGSYRGGGYQGGGSNEYSSMGNEYQPFASNSYYIPRDDGFFESGNSGFHSFRGSQGAPYTLADEARDTGRHMGGLGSTGALRHSAVKFVPSSTGNLDLADLLKPLNLVVQPEKQEENASEGGVEKDISPDLEPSNTRTGMEKPQEDLSQTVKLSGLDLNDTETHIRTEKDSATGATSGAPVFVIDLVGDPSLLPKKEVPDRAASPTPSASSSEEIVFVPRRHRGDTAQKAVARATSRPTGRQQLKKQAIHTKTSETAAQLAPGGEPNILADSTVGVRFEVVIDSTHKPATCHEEVPNEVGGPAGESPAVENKWAGRLRKRKGAGRRKKDDDDEALRDYEENILAQFHAGEAGESSDAMRSRNRPIKNDWFDTTDDEAEKSPSSDSSYREDDEDLKLARLLQRREELGIVGGSDLDSLDAEIMELDADFFPLGAGKRKKKKTKRRGGGNDIDSEDFVPDPSTGHFPSASWTADAYEGFDVMEWDRPSLAKRKGKGKQPAFGLSDSEQEEELQASWAKDREKKKIRKQERKARRAEGMLGNKARKTGKRDPNAKFPEGITMEQLKQEIQAFLENDIQCLTLPPMDKKNRKTVHHIAMAFNLKSKSFGSGKTRFPTLIKTSSSAIYEEDSTKVAQIMRTEAFLARPDIGSGRRGVGKRGAGRGGGAGRARGEWGGAGSVVRHKEGDIVGAGAAELAEDNRGRIMLEKMGYRAGMALGADSNKGIIVPLAAVMKVGKAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHF8</accession>
    <name>A0A2T6ZHF8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1156049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000261">
        <property type="protein sequence ID" value="PUU74921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHF8"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF242">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="446" mass="49074" checksum="642B7CCE0C24DDC9" modified="2018-07-18" version="1">MEKACIQLNVIIVGAGIGGLGAAIAISLAGHRVTVLEAGSGIGEIGAGIQILPNASKILTTWGMRETLLKYATLPKQVNMIGWKGNHIAHMNFGEHAKKYGSPFWDFHRASLHKCLLDRAVELGSKVLVKSRVSDVKFGEAGGGVCTVLLHDGRRLSADLVVGADGINSAMRECLVGHPDKPTPTGDLAYRLMLKTKDIIKDPELRQFVTDPQINYWMGPDAHAVNYVINGGEQFNMVLLVPDDIPEGGATSIKGNVDEMRAIYKDWDPRIGKLLALCKSVCKWKLCIREELPTWSHPSGTFTLLGDAAHATLPYLASGAGMSLEDAAVLGECLSRISSKRDISLALSVYETCRKKRTTRVVQRSNVQQHLYHLHDGPEQRERDAKMKMTPTPVGECLAWRDPEFGPWLLGYEVLRDVEAHWPDEVPVWKFRVEGRRGKGKFSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHS5</accession>
    <name>A0A2T6ZHS5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1091236</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000254">
        <property type="protein sequence ID" value="PUU75033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHS5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHS5"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15 19" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="408"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="867"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="526"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1036"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1056"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU75033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1066" mass="119051" checksum="FF40CE7B916DADE8" modified="2018-07-18" version="1">MGVPALFRWLTNKYPKIVSSVIEEQPQEIDGVVGVVDITQPNPNGEADNLYLDMNGIVHPCSHPEEGEPPETEEAMMLAVFAYTERVVNMVRPRKLLMIAVDGVAPRAKMNQQRSRRFRSAQEAKEKEDETAQLIEQMEKRQGSSFDDVLKNKKVWDSNAITPGTPFMDILAASLKYWIAKKLNDDPAWAKLKIVISDSTVPGEGEHKIMEFIRSQRLSTEYDPNTRHVIYGLDADLIMLGLGTHEPHFRVLREDVFAKEARAKTCKICGQKGHRAEECTGKAKEKQGEFDEKDNALPLKPFVWLHVSILREYLEVELQVSGQPFKFDLERALDDWVFMCFFVGNDFLPHLPSLEIRENGIDTLIAVWKDNIPLMEGYVTKDGTVDLKRVQYILDGLAKQEDQIFKNRKRVDDRREQNNKRRKLEEEARAASGSRGDNFASGGFDSPTVAPAGRGRGRGVPNSAPPPMIPLFKPGDVSKDTKKMNYDMVMNREGIRKANLQNKSAAQALKAQLLTGSPGTAVESLGDSSKTDTSTPEKLSTAASANVSYVIPMKRKSDIMEGGETSKTPGSESEVEDPERDPVRLWEPGYRERYYEQKFHVSPDDAEFRNKVAASYVEGLCWVLLYYFQGCPSWTWYYPYHYAPFAQDFKDVGTLDIKFEKGKPFKPFEQLMGVLPAASKHALPEPFQKLMTEEDSEIIDFYPESFPIDLNGKKFAWQGVALLPFIDEERLLDAAAKIYPKLSAEDTARNAMGHDFLYCADSNPMYDDVTTQLYHKRQISDEYTLDPSTSQGLTGKVIKDPSFIPHGTVPFPLSENGKPKIEGDKSLCVFYEFPKHTHVHKSLLLRGVKPDPPVLSRTDLELVKCKAQGSGRSYGGAPLYRSNSGRGRGRGGGDFQGSYQSNRGPSQGYPGHNHTPSYGNGTWQPPPPPPALSGWGGWGRQNNQPPGGYGNPPPYIAPGPYQRGGQYPAHPPPPPPPPTFPHRGTFGRGQPQPPYNGPGHNYNSSPRDDRYRPGGGGENRYNGHNNDRRDDRSRAGGSGGYRGGRGGAGGNNNRGRGGDNRDLWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHW9</accession>
    <name>A0A2T6ZHW9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1031646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHW9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHW9"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="396" mass="44243" checksum="A48E4D1AABE6A8FB" modified="2018-07-18" version="1">MPSSLNKPPTAPIVPPALLCPSPPQLSSISFQQPIRRILTPADLALFQSSQTHILITSFIRDLNNSVLNLPLSHPAPRSVIVDKLIGVLDAVDAIIDHHPAEEAGGSRFGNAAFRGFYDEVGEKFEGLHEGILEGLEEEGARKGAMKEIKAYFTEAFGNRTRIDYGSGHELNYLIYLLCLQQLSLLEPSTYATLVLHLFTRYLTLMRKIQTTYYLEPAGSHGVWGLDDYQFLPFLFGSSQLYSHPYLRPKCIHDDEILEQFSKDYIYLSCISFINSIKVTAGLRWHSPMLDDISNARNWAKINSGMMTMYEKEVLGKLPIMQHFLFGGLVSAVEGMGGGDGEEEEEREREVVDREGMTHVHSTWGECCGIKVPAAIGARRAGEQTSLRKVPRIPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI77</accession>
    <name>A0A2T6ZI77_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI77"/>
    <dbReference type="OrthoDB" id="5380385at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="37478" checksum="577F2D21BA9A486A" modified="2018-07-18" version="1">MSLFDTLHLLYQIYHRYRNTGDGNGRIRRIHIATRGVVEMRLHRHRTEEQDDAGSPQGGPQTATLLCRFERCAYNTPIRHQFSAVLILQYVKLCGYHGIPVSFSLATGYFASWIIMEVILLIGEGRTAMEPSRAALPEIEPPAVAGRGVFFAQSIAILVSVSILLLRAQNEFKFVHGETVPSFDLRFAVFLIISFSLMYWVDSMPLFVGISLMSGFYVSGHKNSRKVSDRIGLFMAITYIFIITTVFYSSWIVGAAHLPFVSYITYFYASPLFCRGEEGTERRKGCRGMARLEPVLIFGSSALTYAGGLLFFYVFVFKPEGTWMAGWTESFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI88</accession>
    <name>A0A2T6ZI88_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_365395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000244">
        <property type="protein sequence ID" value="PUU75205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI88"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI88"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="24578" checksum="03E381448A61C3A2" modified="2018-07-18" version="1">MHWFFSENRLKVVMPSAMHECAGAWLSKMITRASRRKLLSNDWEDTMDIMTGPEYRNFIGQHAGSFKQPDMAFVPIVGPDWIQCAAFPSVLESGWNESIARREEDARLWQEGSGNAVRVVLQAKVHEPDYRNCIHLVLSVTRAYPDGLGRLALPTHYANIFPIPPDYQKDPTISLDEFYAENCSSTMNAKTEIPLNLSMLRNVAAKYIRDRGYLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZII8</accession>
    <name>A0A2T6ZII8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1090885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000243">
        <property type="protein sequence ID" value="PUU75224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZII8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZII8"/>
    <dbReference type="OrthoDB" id="5420280at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="268" mass="30561" checksum="FE76025E1E741271" modified="2018-07-18" version="1">MPVPLKRTFRQALEEEELDVTNVRGERYIENRRGLNLAERIRILEEKNVLREARIASLDASLDASLDASLDAKIVSLQENDVLQDAKIASLKDDVASLEDELLILKLASQDYRRIRSRFISTFVRDKLKNETPTDIKIIKEGNSTASGGDAAVDALLYDGIGGTSREDSYAFELLYGIHPYDVKKITHKETLEMLNLHASVRANNERTGTDEFYKKFAEFVKALKWSCLNQNYLIVEPANPTCTAYWVLRRCEIYNPRLPVTKLIEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIJ9</accession>
    <name>A0A2T6ZIJ9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1090648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIJ9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIJ9"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="197" mass="21555" checksum="27E306DB0FE758EC" modified="2018-07-18" version="1">MPDLQNFPFISTEEFAGGCVRLGERLKREGIGEVMLSHEMGGVYGLIVRREFVACSESDGHESEDEDEEVQNGGAVEEEEDEELPILYFNLYPPASSAQIPASLQQVYENLTSAATRDVLKSVGIQGAISQTDHPVLGVPYYFVHPCNTAAAMGEWQQRRQDGGEGMEDFTAEKYLTVWVGVVGGAVGLFLPSECMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIV8</accession>
    <name>A0A2T6ZIV8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_994853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000233">
        <property type="protein sequence ID" value="PUU75419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIV8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIV8"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="458" mass="51901" checksum="21A40071E8AE0781" modified="2018-07-18" version="1">MGKPISIYSYQTWKPLLHLLRLTLSLPRVRFRRYRHPPPADDPEREIIIAVMGPSGAGKSYFIKEVSGIEVSDVKVGGNPHSYTSKVQPYSFQYAGAKITLVDTPGFGNTTKSDTEVLADICAWRLLSYKEKRLLSGIIYLHRITDVHLDSPPQKNLGMFERFCGPSVLQNVLLTTTQWSNIDHMLGWQREEDLRRQDFWGGLISKGASLERFMNTRESGLELIYKLMKKEPKPLHIQDQIVEKGMALVETDAGRFINDELISLQKKYAKDLGTLERERQNAVTEKDDEMEKILAQAQAKAQERLEKAAADRGLLADLSEAKMKKREEAEAAERMRAEERDKEDKAVIAVALNDISFGAQITSLFKPYTTKGRLIYDMNDPGEFEKASFDITINYQSNVSFINVWAKTLAGFTDGGVDTNDYIVHNEALYWPKSGGPVTRGTQKFRIFTRVHLSGCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ24</accession>
    <name>A0A2T6ZJ24_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_994461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ24"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ24"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25188" checksum="3A97223E85ED8F10" modified="2018-07-18" version="1" fragment="single">NRIGVFATLTNSYALVATGGSMNFYSVFEAELADVIPICHTTIAGTRIVGRLTAGNRKGLLLPTSTTDQELQHLRNSIPETVKIQRIEERLSALGNVICANDHVALVHPDIERETEEIVADVLGVEVFRQTISENVLVGSYCSLSNQGGIVHPKTSIQDQDELSSLLQVPLVAGSLNRGSPVVGAGMVVNDWMAVTGLDTTATELSVVESVFKLGEGMGPGNLAGGLRDSLVETWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ47</accession>
    <name>A0A2T6ZJ47_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1131205</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000228">
        <property type="protein sequence ID" value="PUU75493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ47"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ47"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="774"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="716"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="876" mass="95321" checksum="E26E10177CFF805F" modified="2018-07-18" version="1">MEKRKLYRELNGARGIGSNASFYGARSWIERLDLVAELSGHEGCINTLCWSRNGELLASGSDDTQVNIHTVYPDFALNTRIDTGHTENIFSVKFMPHSSDRTIISAAGDAQVRIFDVEYASASLNSAANKSNRPLPPASAPAVGQHFFFGRRIVAGSDIVPLKRYSYTLDQNKVYRNHTSRVKRIVTETNPYTFLSCSEDGTVRQWDLRQPSEFYARPTWRRRDGRGRGYYGMTVIDDEDEDGLASGGAPPLIDYRPWGIELNAVSCSTSQPFYIALGGRNLNCFLHDRRMSGRDLAAERGSGRSSSSSSSSGSSATSTMDTATRCVRKFVPRPGSGGGWGDPHITSCKISDVHPDNVLVSWSGDGVYMFNINQSPEEPSSGSDKQGKGTWGTDERRDRDASDPGPGGGSSSGGGGGNTDEPTTGRLRESDRDSSSSSFPSPSSDEEGESEAETVDRHQDRDQTPSTPSPEGQFLSTAGLLMALKQKLATLHTTSSSTETEEELSTDIYAAARDTYRRIRRKILSQEQRDLEFLTLATLTENNSEFRRRRGERNERARERRKARDWVRAVGHYAHAVLLLGQVDDEEDFEELEYTRDVRYRVFKLACGVAAGGREGGLEVVRGEHGVGFGFGDDGDDGDEDPDEERMLREYFTDILINASPQPILDPSGNPLYNSESDLITSLRALMHSPSPPPTPHLKITLLPALLLTLCPPISTTSPTPSVSPTPSPPLHQTHHQPNPHALIPPSHHSTLYLGHANTLTIKDVGFLGQQDEYVVSGSDDGNFFIWDARSAQIVNILAGDEEVVNVVVGHPRVPVLAVAGIGCRVGIFGVEGGSTGGRGRMGDVYKIVARNEGASGAGGREVVGDGAVRAVCVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJH4</accession>
    <name>A0A2T6ZJH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_993665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000220">
        <property type="protein sequence ID" value="PUU75641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJH4"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="13294" checksum="617C972D5DD516B1" modified="2018-07-18" version="1">MGSLLTSRPDPSLFLDEPTSELDSQSPFLLDFQLSQAWQAIISTILQLSSMLIQQFDMTLARNPGGKTFYFGPIGKSGADVILYFLREGSLLSSWQERYGVRHPDSFEGYKEQWKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJU0</accession>
    <name>A0A2T6ZJU0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1130803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJU0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJU0"/>
    <dbReference type="OrthoDB" id="4202778at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33324:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="398" mass="44740" checksum="DB72D009BC3E5BF0" modified="2018-07-18" version="1">MPRDYSENTIWTKAETGRIIQWLEEPENLRKIKKGSGITKKTIVAEIAAQIPTKEAIKVGYKYDNIMKSYRAAAKLNNQSGWGLSERDLDEGRRSLRDKLLSRCPYFFRLERILGDRPNVRPPVSYDSGHDANDTAATIEQLLIAISNDNPEEEEEGQLPLVGQEGIGGEVEGEGENGASISREGEEQEREKEWQGEGMRIESGGNEEEVAILRGNGREEEDGGSSDRGERSRVSQETTGGIEEEEVVVMGENRESQGVQRAKRASSSYSSAMRGARKRRFPEMLVAESDNDGASSGTQRRRKGGSNALIEAVGILASAKAEGEEKKFEFLNRHLIQQGELRQQEIELEREKLEVERERARGEQRRTELLMLQLRATMGKRTTNNMEGFEELNFESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJV0</accession>
    <name>A0A2T6ZJV0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ligand-effect modulator 3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1130760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJV0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJV0"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU75767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="391" mass="43805" checksum="CA257CD96B114D41" modified="2018-07-18" version="1">MASSDGEPEQQSRRKSRKPGNTAFKQQRLKAWQPILTPRTVLPLLFALGIVLGPIGGLMIWGSSKTQEISINYTDCNEATGGKLQDIPSKHVHTYFSSPVDDRAMWMYSSNGTSDDEQGTCTLHFTLPNKLEPPVFFYYRLTNFYQNHRRYVKSLDEKQLKGDSRSKGALVTCSPLDANSEGRIYYPCGLIANSMFNDTFDPPVLLNTQDGSGKDNETYHMTNKGISWNSDRGRYGATKYTPDQVVPPPYWVKKYGEKYTNESLPNLHEMEEFQVWMRTAGFPMFNKLAMRNDSAPMKKGTYEVRIADNFPSSDYAGTKSIVISTSSPLGGRNPWLGIVYVFVSGLCILLGAFFTVSHLYRPRKLGDHTHLTFDTEPAPAPAQATASGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJZ4</accession>
    <name>A0A2T6ZJZ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1152327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000214">
        <property type="protein sequence ID" value="PUU75810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJZ4"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="64775" checksum="07E4E4E46F1250B4" modified="2018-07-18" version="1">MSNERHRLVVGVDFGTTYSGLAYIHTTEPDYKNIEVIDSWPGRGNTNHAKVPTEISYSESGATWGYDIPPNGIRHGFFKLLLDVNAAATQYDNPRLATSNPQSMESSYANIPLPAGKTAAETTTDYLKLLYTHLMKTLQQRFICTLYNTPIQFVLTTPAIWSHEAQNATCQAAKDAGFTSRAGDTLTMVSEPEAAASYCLKEFYHERSNSDSPLKPGERIVICDAGGGTADLITYTVEKVSPMLSLCEAVVGSGGKCGSVAVDRAFLSLLESRIGPSFRGWPARKTAPQSSLMRSFDTAKKEFGTTTRTDFWRIPVGYVRDDPKNGIEDGELRLTVADMKGLFDPIVKQVISLVEQQVRDSNKLDSSNKVSTIFLVGGFGESAYLYKEMQAGVRRQSYHIRVINPNFSWSAVVRGSVLHGVQGIVHTRKLKQHYGMRLGIEFKPGVHDEEDSYINPFDEIKYTRDNVKWVARKGDDANNEKVISIPCVNSFLPGNKRTIKLTLVGCKFDNPPRSAKHWMVDTLGTVICDVSMMPPSAFQVKRSGAFFQNAVSRASYTIDMKVGSADLELDLMHAGKSYGKARIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJZ5</accession>
    <name>A0A2T6ZJZ5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_993210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJZ5"/>
    <dbReference type="OrthoDB" id="434240at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000382">
        <property type="entry name" value="Nitrate transporter CrnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="HIGH-AFFINITY NITRATE TRANSPORTER 2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="34"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU75734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="502" mass="54010" checksum="F03ADBF836B8BF77" modified="2018-07-18" version="1">MQLSLLWKAPTVNPVNHKAQSVPILNPFDKYGRTFFFSTFGFMIAFLSWYAFPPLMGKTIKKDLHLSQTEVANSNVLALTATLVVRFLIGPLCDRFGPRLCFAGVLLAGAVPTALAGLVTNATGLLALRFFVGVLGATFVPCQVWSTGFFDKNVVGTANGLMAGIGNAGGGITYFVMPAVFDSLVHERGLTPHKAWRVAFVVPFILIVIMALGMIFLCEDTPTGAWADRHNFSPRTIEGKIVDATRNISDAPTTDKDAKGTSYTEKDKKNSDPESASSNGSIDLETVAQSEVIQAPTFKEAMQVIFSLQCLMLAAPYACSFGGELAINSILGSFYMKNFPHLGQTKSGRWAAMFGLLNLFCRPAGGIIADIIYRHTKSVAAKKWWLVFIGCMQGVFCLAIGLVNPHHESTMFGLVAGLAFFMDASNGASFAIVPHVHPFANGILSGVVGASGNLGGVIFSIIFRYNGVKYDRVIMIIGAICIGINLSISWIRPIPKGQIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK38</accession>
    <name>A0A2T6ZK38_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK38"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="171" mass="19255" checksum="BE3BD91F9D9FEA95" modified="2018-07-18" version="1">MGFSTYPFGDGENGRMIGLVLVFVFFPFGPLSVISSRSGLEMMIYSKKVPEANSYICLNYVLAICCSFYSLISVRFGGLFILFSISSGQVQGFCFFLPFPFYLSQYTLLLATAAAYLSLSSSSLLILFPSPFFLHWFLRVNYPLLYLLIPMNNHPLYCGDHSSSSFPPHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK65</accession>
    <name>A0A2T6ZK65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1130570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK65"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK65"/>
    <dbReference type="OrthoDB" id="5430620at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018909">
        <property type="entry name" value="Eng1_septum"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10645">
        <property type="entry name" value="Carb_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015518661" evidence="1">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-1,3(4)-beta-glucanase 1 carbohydrate binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-1,3(4)-beta-glucanase 1 carbohydrate binding" evidence="2">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="134" mass="14459" checksum="FB34AFD6666D8A66" modified="2018-07-18" version="1">MQFTTYILATFALISAALATPVGGLVERDLLQCGSQQYDPKNYTCYADDNNLLCPISNGVIFQPCGPACFDPANYTCINGQLAPVGNCNGQVFDKNSYVCVNNHLCPVGFPNLCGEACYSLSQYHCVNGQLVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKJ2</accession>
    <name>A0A2T6ZKJ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_290114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU76019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKJ2"/>
    <dbReference type="OrthoDB" id="5330919at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="238" mass="27453" checksum="12169FC220EFFD83" modified="2018-07-18" version="1">MIPQYAYDDESTIYLRRTARLPTTSSTAKGDTIGHVYKFHTSESMFDFQKALTSERVYQHLVKRVASVKFKRSSENGTHSYHDVCLQLWHENPPADALFTDVASGGSGSFLTCFLTDDITLEHEDHDLKLMLVPTKYGGYSWKSPKPWKSPKTVKAAIRGSESRKGGFRLDKDKISPDDQDSFENFSYIHINFRDLEYLNKFKKLWNKMMAMRRTERERISGVRDKLKEAIRAPLAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL39</accession>
    <name>A0A2T6ZL39_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CobW/HypB/UreG, nucleotide-binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1088784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000197">
        <property type="protein sequence ID" value="PUU76193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL39"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="8">
        <location>
            <begin position="35"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="9">
        <location>
            <begin position="289"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="42874" checksum="9506F60F18D067FE" modified="2018-07-18" version="1">MSSDHFDLDDDEEPPALVSTEIPLDLEDLQLSKAPITIVTGYLGAGKTTLLNYILTEQHSKKIAVILNEFGNSSDIEKSLTVQKDGQQVEEWLELANGCICCSVKDMGVAAIEKLMERRGKFDYILLETTGLADPGNIAPMFWLDEALKSTIFLDGIVTLVDAANIIRTLEDQEAFSRDDEAGVGMTTAHLQISHADVVVINKADLVTREEIEVVKQRIAGMNGLARIIVTEKGKVDNLEEWLLDLKAYETVGELKTPIKTQLDETISTVSLELPELDEEMLDSLDAWIRSLLWEAEVPSPPKGLGDRVPGDSSKQPILDIHRLKGRAITKTGNALLIQGVRETFEIFDAPDQNSAIKAGGKLVLIGRGLRDVDVNESLKWFLSRGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLE7</accession>
    <name>A0A2T6ZLE7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_990913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000192">
        <property type="protein sequence ID" value="PUU76310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLE7"/>
    <dbReference type="OrthoDB" id="5283561at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53172" checksum="FD723BCD94C8B266" modified="2018-07-18" version="1">MPSIEDLPFEILSEILSIATQLNSTETPSYTYGLTQARKTLQRTQTQIYLRGRTTPDALRWDLVNSFRLVNSRWHQWALGYAMKEMYIRKWSGGERWLYKSTEEQIRSSAAAGVFPVVYQHPYTSVKSTVSLLRDYPHIAQHVRRVWFNGIYQFDTSRYIFDVLGNCTNLRTAAIPWTSLRYGTEEDWKNLMSFPQLTSIEFLAVDLKDSLLSADVNHTDNNVLPSLDFSRITRLKIFGDSNLSPITDDDLITISRTATSLQEIHITSSTSITIKGLAALVSASRTSLKLLEYKPLSDSGFTHPSSVESHPQIHICALLSSCPKLEDLAITLPTACSELFSDHSVAWHETIRLRIAGSGVCRFPTLDANIAEFSKLLESARELLAKKKNGLGVEISVGKFLFDTKTRLVHGNYKIAKTVSEMGWGPLEQVSLKGPYGATGLYGDEDVKGEWSAISEEEFWEGMRWGFVKFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLJ0</accession>
    <name>A0A2T6ZLJ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1102425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLJ0"/>
    <dbReference type="OrthoDB" id="5355812at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="245" mass="27669" checksum="7F550240DDD9D2DB" modified="2018-07-18" version="1">MLSAISRRIRTPGCQLTTASPIRVRPFTARQSNEQPNERSNEQPNERSNEQPNERSNERSAVTMRRPIVRRTMLPIRGAGQIPPGDVIACILEGEMDQILMGHTRYLYRKFFFNEATRYVWLYVKRPVAKLSYVAEIGSCKLVPHELDMLPYYTNKRMEALEEAKAANIIRMIDREVGEGTVDENIGALPRMTYYAGDFTKFDAPDNMAYTWGYLRGDVGKGVLTGPAASEIYQCPGADVVILAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLS3</accession>
    <name>A0A2T6ZLS3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_253336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000189">
        <property type="protein sequence ID" value="PUU76435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLS3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLS3"/>
    <dbReference type="OrthoDB" id="2134400at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="688" mass="73470" checksum="7FDC2A18810DBBF4" modified="2018-07-18" version="1">MPKPEKPAKGTPEYAAYKKAKKERKERREERREHGRSKSLTVKTDQSTLSAQSHSRAGSEFSYISSVGSGAEEEPGKYKKAAEEAAKEIARERGLLSGYSLVGGASASGSVSAGYQGSYGGSESYSPVSPVSPVSPVSPSPGGARQRSHSQNRSYPSSAVQVPAPPPGQYPPYQQYPPPNPYPPAAGLAPPGQYGAPAAYPGYGYPPGYAGPPPLPPPSPGIYPQVSPNAPPPHDPQYAPLPPGFGGGGGVYPPGETPPQHSNPDYYAETQSPPQGTQGTPSYFPGQAGSSASPYPAPLQLPAPPLPSQYPPVSGSSTTGVSPGGHGAVSVPPPRPPKHGFLDSLKIPSFSSLSIKNDKPSQLPPPSPALQPYHGTYQSISPLPSPTLSPSPLFSASGSISIAGHSLNSAFSLGPSVFSPSPGGQSLHQTLTQHSSEKSMAAPVSPAGPPRPATPPYIPTEDAKALLSALKHTFRPPTGPLIDILPTLSPSQVLQLRQEYKSIFKQVNVAKHIKTVFPSNTYGGFGKVAFAVALGPYESEGWFANCWYQRRETRNELLIEALMGKSADEIRKIKAGFKDAKYLNSLEKVVRNELEGNKFRMAVLIQLEGLRMEESEEIKVDSVKEDVRRLGEVMERKDARGGETIMIEILVNRSDRWIREMAGQYKATYQRDLAKAVMRHSKNLVVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM77</accession>
    <name>A0A2T6ZM77_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_990075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000183">
        <property type="protein sequence ID" value="PUU76583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM77"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015371481" description="Hydrophobin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="15570" checksum="2840E4466537138E" modified="2018-07-18" version="1">MRFSIISILALALTVSASPLVARQITTVADTTQVADGNQDVGNQGQNAGNSATNKGKVIGDYTVEQGVQTCGNAQLNCCNKIEKQGDTTNAGLLGSLFGSGDIGVQCTPINVAAVIAAQVPINKQCQANAACCQGESSQNGLVNLGCVALSSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPG2</accession>
    <name>A0A2T6ZPG2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1086352</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="NESQ01000154">
        <property type="protein sequence ID" value="PUU77380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPG2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPG2"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="180"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="437"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="603"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU77380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="736" mass="82082" checksum="C28911166A574497" modified="2018-07-18" version="1">MASSSTRHAPGFYPTPSKSTIAPPAVDTDTVELKDMIASSPPPELELKDDIIKLSVNGDEAAVRALLDSGKVTADWLGEDGVGPLHWAAINNRYAICKLLLERGAAVNAAGGESNATPIMWAGQRGHYYLVNLLLKHGADPCMKDVHGYNVLHLTTFEGNIFLLVLLLHHGIPVDIPDSNQHTSLMWAAYKGYSNAVDLFLRWGADVRAVDDMGFTALHWALVRGNFGCIQKLVEYGADRFAETNEGKTPAIVAEELKTQRVWWDALEDCGYDKDGNPLHPNGTILGIRVADKTTVLNRFFLCWPTLIIWVMVMCLTYLSWIPGVLSAVIFGLGLHWIATKAGDYAEGDQKVVNNTPYLAGIFVGTIFWTAERWLFSILPNTFSSAPFSNMFFAVIFSSCAYFYTICMIYHPGYIPKLSSVTEQKAVIDELLSLWKFDNSTFCVECMVRVPLRSKHCRKCNRCVAKHDHHCPWVFNCIGVRNHRQFFLYVLSLEIGIFMLVRLVIIHYTVLGLVPNAECSILAEPFCSAVLQDPFTAYIFVWGALQASWVTMLLLVQLVQIARAQTTWEFMTSGRRHHSHDNKITSAVTSALATGATTMEGAQLLSTPRGPDPAAEASGGHHHPSHRHRRGGNDTYFSRMKKLLGVDVLVHTAQDASNPARRRRVNPFSRGILTNCKDFWCDPAPVFKENVINDGEALLGGARVDYYRMYEAPPRMHAGRSDTTRYQRIAEEEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPM4</accession>
    <name>A0A2T6ZPM4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1086320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPM4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPM4"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035097">
        <property type="term" value="C:histone methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000228">
        <property type="entry name" value="COMPASS-like H3K4 histone methylase component WDR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059122">
        <property type="entry name" value="Beta-prop_WDR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="5">
        <location>
            <begin position="35"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="333" mass="36561" checksum="F27C05E75907A630" modified="2018-07-18" version="1">MSTQEPPSGQPEQTDIRMTDSSSTRAVPNYALKYTLKGHKMGVSSVKFSPDGAWLASCSADQTIKIWHAKTGKYEQTLEGHMAGISDIDWAPDSLTLVSGSDDKTLRLWDVASGKMLRLLRGHHNAVYTVAFSPRGNIVASGSYDEAVRLWDIRSGKCMKTLPAHGDPVSGVHFNRDGTMIVSCSHDGLIRIWDVTTGQCLRTLVEEDNAPVMAVKFSPNGKYLLAGTKDSCVRLWDYHRGKCLKTYMGHKNEKYSIFSTFIIANGSCFVMAGSENSDVFIWDIQTKEIVHLLVGHPDVVLGVDSHPTEKIVASCGLDGTVMVWMDSAEGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPN0</accession>
    <name>A0A2T6ZPN0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1086325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000153">
        <property type="protein sequence ID" value="PUU77435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPN0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPN0"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001074">
        <property type="entry name" value="Probable SOF1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001105">
        <property type="entry name" value="WD40-repeat-containing domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="355"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="402"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="445" mass="50201" checksum="8FEC4E5BAB47F4E1" modified="2018-07-18" version="1">MKVKALSRSSLTYSPAGTNATVQPRNLDPEIHPFEKAREYTRALNATKLERMFAAPFIAQLGTGHVDGVYSLAKDIRALDRIASGSGDGEVKIWDLADRKEVLTVKAHEGIVKGLCFASVNGDDRLLSCASDRTVKLWDPRGAGVSSNIPAATYLGPGAFNGVSHHRVDHTFATASSVIDIWDTNRSKPITTLQWGADTINTVKFNQSETSILASAGSDRTLTFYDLRTSSPTAKVVTRLRTNAICWNPMEPFNLAAANEDHNTYIFDMRKLNRALNVLKDHVAAVMDVDYSPTGEELVTGSYDRTVRIYRAREGHSRDIYHTKRMQRIFSVAFTTDTRYILSGSDDGNVRLWRAEASQRSHVRSARERTKLEYDNALKERYKHMPEIRRIAKHRHVPKPIKKAGEIKKVEEASLKRKEENRRRHSKKGQMRRIPQREAMVIARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQV5</accession>
    <name>A0A2T6ZQV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1085340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000137">
        <property type="protein sequence ID" value="PUU77869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQV5"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="57"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU77869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="370" mass="41621" checksum="8CB0D0A9D141321B" modified="2018-07-18" version="1">MYPLPIPANEMPGEPRLFRGNLPSLISYPSPPLPDCPEPQPEPLGAYCVPVREPPSWRLDYKIGTGASGTVFLESVHIPGMKSPELWAVKRISRTLSSFTFKQYEAEIKNLQALAGHEWFVKFNSTYEDTHYMYISMEYIPMGDMSQSFTDDYRWNESDTKVVIKQLLYGLAIMHKEGITHRDLKPENIFLYLPENQTNVLRVKIGDFGTSKRIPSSNASTYLKTTTGTQSYMAPEVHDTSQPKTNRVDIWSLGCVLYRMVAGNLLFNDPVQVWKYALTASSSPLALDNIGLLAPGVSFLRDILQSIPEDRPSAEDCQKKSWILSEDPGPKYAIGTDLYARLSKINQRAPNVHSFSDMVANRALDSSSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQX2</accession>
    <name>A0A2T6ZQX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1127590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQX2"/>
    <dbReference type="OrthoDB" id="5340195at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF3">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="681" mass="75580" checksum="E6D3D53D3CF95C00" modified="2018-07-18" version="1">MSHWTGIPMGKNMDPYDPYRPQGDRYDEIVPSPPATTGPTENLLRTRTVADDSPDGTKAERVVSVARSIASTRTNASNASRMRERIRRGLLWGTKLHWFLPSAMVGLFILGLLGALLHHWFYLSLDGEGAQDQLIMVGFGTAFAFFTKASLVGSIVLAYRQRIWYTLRTTAITVKGIDSLFSLTEDPTCFYSKDVVFKAKIATVMALATWLIPFAAVLSPGALTARQTRVPSQAVCTIPTFNTSAQNDVNPIIPKYGLGGYNLIDLNKSEGPDGLWYFDQAGYQMTQSASISDYLRAPRQVASPCKGYNCTWNVGFDAPWYECQEKSIDEARKALDTMPWGDAGNDSWAPRGPLTLYAVSDGVEYAEPQPPYQNGSSNMQGYFFAEPTIRVGYVVDTGVPVVEGSIDSNNGSWKTVFEPHWLSCDLFKASWNVTFNFVGETQSASVKASNPRRVFEPPKMGPGNPKYLENALYYSFGEVIRKRLSNGFGFKKGYLDTMQYSNFHPLVNQTTRLAINDVKGGVEKLVSDLGLTLLGIPYLEIALNTTVECKKWRYENRFHYNRKSLWVGYAISIFATLVFVIVGMHSIYLNGITSDTLFSKVLVTTRNPTLDKLVEKHEGVCLGGDPFPEELEKTRLRFGIIDRGDGGTHTAFGTERETIVMVGAGRNRGWRTAGGQEAMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR87</accession>
    <name>A0A2T6ZR87_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_127383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR87"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="75" mass="8472" checksum="7DD09C287CE9B084" modified="2018-07-18" version="1">MVLAYSMMLPFAFYFQILLAARVWYCTVQVLGCYSVGEKKKTGREGRGVVDDRDRICGAPEVLDHVSRVLCILVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRH7</accession>
    <name>A0A2T6ZRH7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U6 snRNA phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">USB1</name>
        <name evidence="7" type="ORF">B9Z19DRAFT_1084773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 2H phosphoesterase superfamily. USB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRH7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRH7"/>
    <dbReference type="OrthoDB" id="49151at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990838">
        <property type="term" value="F:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034477">
        <property type="term" value="P:U6 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03040">
        <property type="entry name" value="USB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027521">
        <property type="entry name" value="Usb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13522:SF3">
        <property type="entry name" value="U6 SNRNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09749">
        <property type="entry name" value="HVSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="327" mass="36653" checksum="95D3651B2986EE13" modified="2018-07-18" version="1">MAPLANSLVEYSDSDSDSPPPAKVTKTTHPIPVTNQSPTSTSKRPKASSSNSLPPLPSRFHDLYAVAPRLGQQDDPSLHGGRKRSIPHVQGNWPTHIFIEWHLSRLEFDVLNDAYHTASTITAEAGVKLESHLKSDLGSEQPLHLSLSKPNVLTTVQREGFLELLTDRLDKTRIKPFSVEFTGLEFVSNNDRTRWFFVLGATKGEDAQLTRLLQLANHTFEAFEQPPLYAENGDKLDGFHVSLAWSLTEPDKNTKARVFEALKKHACWDKIFGKREVERLKLAIDAIKVKVGNVVHIIELGKKEKQGEAGNSKKRRASYDIHEKRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS07</accession>
    <name>A0A2T6ZS07_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator complex subunit 27-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1048832</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS07"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS07"/>
    <dbReference type="OrthoDB" id="5326237at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39991" checksum="0CC0F7CDD6C16E4A" modified="2018-07-18" version="1">MSKQPNGNAPPPPQLQQPQSQQPAGSEEWSDEKLVDALKRLDDLHNKLISLRTVIPRLTQPLSTKYPSPAEFYADLASRAQSSSQEVLDFNSSWVNGKEIFDRAVASRAKEPGGIPRLSIHDTFMPDDEEEEEEEVKVDPKPEDTEMKDAGDQLEEEEEDEMKEDEIETPDAQIPTVIGDFKGRHPNIGVEVSDGEESGNRTVRLKLPAPTDLLFTIDMHLSTNSSTSTDKSDPATSTRRFIVTSIVNSKKPEQQPIPHLYTALLRSITMRPNAGNLQMLLEMIGTYTSLFTTPCSKCNKMTGGTKAELPVVRRKRLVPVEEAAPSATNGVVSANTSEVANKKKGKVKKEKAWLSFHEVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSC3</accession>
    <name>A0A2T6ZSC3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Redoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1126862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSC3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSC3"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="16578" checksum="641A48296F5692E3" modified="2018-07-18" version="1">MISVGSSIPAAPGSLWVEKDNNTVSFPSSGKYIIVGVPGAFTPPCSSQVPGYVENYEKLKEKGISAVYIVAVNDIFVVNAWKEKLAKDSGVHFLSDSKGEFTKSVGLDFDASGLLGNTRSQRYAAVVEDGKVVNLQVEDEAPNVTVTHADKILGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSC5</accession>
    <name>A0A2T6ZSC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1126836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000120">
        <property type="protein sequence ID" value="PUU78400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSC5"/>
    <dbReference type="OrthoDB" id="5429256at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19559" checksum="6535762E616AC341" modified="2018-07-18" version="1">MAPQPVAKNPDGMSGLNHLLSSISSIFKSKPPSFRTSGEGIDGMKPKDLVTPSLPVPPIITSEEPTGLETSPWSKVPDLQKTDDYDELMSNPWGDKLKRSIQYPARLIMGMDRASIDTPVQQLWTGEYHLSYTQELSLVMLGSLITVFMVAAMIWAIVMVKIKRKPRYRIELGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSG1</accession>
    <name>A0A2T6ZSG1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSG1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="52" mass="5841" checksum="499FB9D86CB5566A" modified="2018-07-18" version="1">MNLLLPSSSPITIFSHFTYLFISMISQSRHIQSPETPRHGIPSLLSPPVQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSG9</accession>
    <name>A0A2T6ZSG9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1065043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSG9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSG9"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="95"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="283"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU78417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="65412" checksum="C62AE0BADF27D338" modified="2018-07-18" version="1">MAPPSMMTPFLRSGTPSQSGEHQVSSAVHSAVHSRSHSPTDFDTSYNEDLRSQLKVRGLLPPHVESYELQKARCLEQIAQKSNPIDKYMYLSNLRNTNVNLFYRLLMDNMKEITPLVYTPVVGEACVKWSHIYTQPEGLYLSYADRGNLRAILDNWTAEHVDIAVVTDGSRILGLGDLGVNGMGIPVGKLALYVGCAGIQPDRTLPITIDVGTENAANLKDPLYLGAKMHRVSEAEQLEFLDEMMIALNDKWPGLLVQFEDFKNPFPSLERYRNTYTCFNDDIQGTGAVVLGGTINALKNTGIPFKDQKLVFFGAGSAAVGVAKQICELFIKSGIPESDARKMFWLVDSKGMVANDRGDTLQEHKIYFSRDDNNGQQFKSLEEVVDYVKPTALMGLSTIGGAFTESVVRKMASYNEKPIIFPLSNPSSKSECTFEQAMQWTNNKVIFASGSPFPDFEADGKVYTPGQGNNMYVFPGIGLGTVLCEAVHVTQEMIYASAVGLAESLTDEEREKGLLYPNLDRIRSISVIVARSVIRAAQKENLDKNKTLQWLNDMELDNYIRSKMYNPAGGDHSGASSPTLEVNGQPAQLPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSK1</accession>
    <name>A0A2T6ZSK1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1065070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSK1"/>
    <dbReference type="OrthoDB" id="5328405at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="39683" checksum="CFF578C554A401CF" modified="2018-07-18" version="1">MHRFKSTSDSQASYLQAQLKLEREKSENLQRRIESLEAEQSLFQERESALLDIISHYKSDMSENFERLRRAAAASLPQRENGTVTEPATGPFLHRVTEIVHTIAENMEKLSEVIVRSEETHTPVSVSQEVLDIFLDGNRLLAELPRISEDFAQQVLALRNLCVSFQDSYVPLVLDAYDSHSLAIHDSFAGACPPAHPEVLFVHFHNLAPMLKKFCLDSTSCTAAHQEDCVHNTIPHVFESLSISMTHPGLDWQALRRAIFASVVFATGLQGEAFGLVDVAGVRGARAWEEFHEWDINEESWERRDALRTGLLEVYWRVADQDEQGGGKEAGACERRFGGGMVTLEKTYSRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTP7</accession>
    <name>A0A2T6ZTP7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_32259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTP7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTP7"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="39417" checksum="D13BEE087C07E529" modified="2018-07-18" version="1">MNTRPQIATTGRPQALSATLNQDNSCFSIGLDSGFCVYNTDPCDLQISRSLGAGIGVACMLGRANYLALVGGGRSPKFPPNKVIIWDDIKQKAVITLEFRSEVHAVRLSRQRIIVVLIGTVHIYAFSSPPTRLHVFETHDNPLGLVALSSKFLAFPGRTPGHVNIFDLATGIVSIIPAHSTPLSAITISPQDDLLATASETGTLIHVYSTATSRMIRELRRGIDKAAIFSLAISPSSSRLAVTSDKNTLHVFELPSLSSVSQPPVRPSSSHSTASNAPSGDNRRYSLLSKLPLLPKYFSSEWSAAHAPFEGGGRGALGWIGEDSVVAVGIGGKTGEARWEKFVIVEAENGGGIECIREGWRRYLDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUE3</accession>
    <name>A0A2T6ZUE3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1082436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUE3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUE3"/>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="290" mass="33537" checksum="F2C0636AAD87543C" modified="2018-07-18" version="1">MSLLIPLRRTVCLAPTCVKRTLTTTAALRDVGPESPHYIDMPTSPIVRSYRKPPPKGKLPRPRPIAENVESALNATPEPRESRQVDPSANEEAKSYIEWKNKMSSMRRRNLREGLTELRKRAMQTAQRRQEALEKRNKERDEQLNTAMREDVRLTLPSVLSTLRSEDITVMHRMTPERVEEKRQLRLAKEQEKKEEKMEMLHELYLNAREFLLTESDLDEAIARTFKPQNALVKRYPPTMEEMLRTIEGTGASFGMDNDPRLIEVAGTLTGGKLPPSKREQVDDFKLTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUK0</accession>
    <name>A0A2T6ZUK0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1125541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KNR4/SMI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUK0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUK0"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009203">
        <property type="entry name" value="Knr4/Smi1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017023">
        <property type="entry name" value="KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="3">
        <location>
            <begin position="156"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="513" mass="56424" checksum="5E2844520144EA33" modified="2018-07-18" version="1">MAPGLGSGFRSFWHAMTSNDRHAGHDSPYRSHSNMGNQHIGVGRNPELQSVTSPGVDTSLNLSYRDDNHSTTALASQNGLYSSRPLNGNIQGPNSPYSPGMRSATLQSDGSPGGIALQDFGTDGLPPPPPVSHSWSRIDRWCEDNYPELFDQLCTPASVNDINELEYSLDCSLPMEVRDSLQIHDGQERGGMPTGLMFGAMLLDCEEMLDEWKNWRKVEKEYLAKPTLAPPTPNGEPGPSRLETSSIGRQNLQARQESQPEGAVVKAYAHPGWIPMIRDWGGNNIAVDLAPGPNGTWGQVILFGRDYDTKFVVAKSWAHFLAMVADDLASSHWWVDEETQELKLKDPRAPRSEPPYMEILRVRNERKYGRRRVRKSMSPTQSPHPSTMSPTAFGAVNVQGPRGGLARPPREENTMSNNHLKPPSKKPSKLLRSVAEELPAPIPVHTKVQSSLAKGPATSNLLDEPLLEEKLSDTVQKLEDVALDDDKKLKRAASDIASHPPPPATVQRSSLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUQ9</accession>
    <name>A0A2T6ZUQ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUQ9"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="187" mass="21041" checksum="4FF22CAABC9112F0" modified="2018-07-18" version="1">MSPSNPTIILSQEPVKGATSQTFRDAMVVRSAVFVEEQGVVAENEFDDADKHCYHIVAYDSDTDVSEKIPIGTIRIVPGPHKHHPGEPIPVGQEHANYIKLGRWATSKAYRGHGVGRKLIDAAVEWAARNEFTGDDGSEWNRMCLVHAQTRIVRLWEKAGFVIDESMGEWDEEGIMHRGLWRRIPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV27</accession>
    <name>A0A2T6ZV27_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1176653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000096">
        <property type="protein sequence ID" value="PUU79264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV27"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV27"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="139"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="388" mass="40475" checksum="2330158BDFE6412B" modified="2018-07-18" version="1">MAEHIIPNQYIIVFKSDIPKERCQEHCQWATELHTQRISARSADSDAPETSGVLHHYSFPTWNGYAGSFDEDSKNEIETREEVDFIEPDYKVYTKALVTQSNVPSWGLARISHNRKLTPETRTTYTYDSSAGEGARAYVIDTGILADHEDFGGRATFGHNAVPGSSDTDMNGHGTHVSATIGGTKYGVAKKTTIIGVKVLGDNGSGSNSGVIAGLQWAADHAEADGVINKSVANMSLGGQKSQAMNSAVAAVIRMGMTVCVAAGNESADANTSSPASEPTAITVGAIDDTDALASYSNFGSLVDVVSPGTNITSAWIGASLDKTNTISGTSMATPHVTGLAAYLIAKEGLSGSTAVTKRIKALAGKNPGKVAKAGTVNIVAYNGAASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVZ7</accession>
    <name>A0A2T6ZVZ7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bromodomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1081186</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVZ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVZ7"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04717">
        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05522">
        <property type="entry name" value="Bromo_Rsc1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048047">
        <property type="entry name" value="RSC1/2_bromodom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="254"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="374"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU79653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="848" mass="96655" checksum="DBF543B916D1E680" modified="2018-07-18" version="1">MVTVRNPTPKLSDELYRAMQTILDSLFSRKDPDGRDISAAFHDLLPKRQYADYYKLIKHPQALNPVQNNVKRKTYASFSAFVRDCTQIFHNAKLYNRHGSVIYVDAETLEATLRADLTRVKDTGAITESDATLPDLGPLPPPSPSGSQGSPDPEEDSAAEEEEEEEEEEEEEDEPEEDTGKKRRTSARRRNLTKSSKRDAGSGDEGQGGGEGSRQKDLSDPRRKRGRPPRVDTPMEIRVKNVLKALRKLKDESDGRLRISTFEKLPEKKEFPEYFQEIKDPIALDIIRKNVKRREYKTFDHFIADMELMFENAKSFNEDDSDVYGDAVILQEEMRRAAEVEKAKKDEDITGGEEGERGNKPTRLPLEKVEHRGETYRVGDWIHIINPNDPNKPTVGQIFRTWKDHEGQIWINACWYYRPEQTVHWAEKKFYVDEVVKTGQYRDHHIDEVLSKCFVMFFTRYSRGRPKGVDEKKCPIYVCESRYNEIEKHFNKIKTWKSCIPDEVRGQDYELDAFEKQQVLKKLPSPILHLLPENAHEDDPLPDAKMGVENAPPIIGAVFKRPRRENDSPPPEPTPPPAPMPTPTPVAPPPRVPVNPDYTETMSMTQMYKQAHLAASITPSTPQGNSHSAGSPTPSGHHQSVRTPMTPQYSYSHQQHQGTPATLHRSHSGSYPPSGTPQMSAQMLAQQQQQQPLLLQQQQQQQQLQQHQLQQKQYNPPAPPTTFTLPDSVTNNIPAETANQFLRDAEGRLLWFTVPPLAPERPVVEGQITGHSLAYLARKEEIEERKRKRRLVLEEEEKVRKKVKEEERDKVMKAAEEVMIKALKKLAGQVIPSKGGNQVNGNGEGQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWA2</accession>
    <name>A0A2T6ZWA2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_796904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWA2"/>
    <dbReference type="OrthoDB" id="5388655at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="643" mass="69961" checksum="F78B6EFC664DB260" modified="2018-07-18" version="1">MTEQSPLGSGFDSVYHISNDSKEDPFSDPPALNPQVSTGLAYTNEVKQSVWPSLSSKVALAEKSANHPILRNTTAAITNDAASPGDTSRNSGPPPRPHKIRHYAPSPEGQDLPCHLSPSKTWGPISRDNFRRFSTRAAEEVSMPCNTLPTEPGIDQHGMADDNTRADAWVRGKTICVIEKTAEKTMGSSPPGARYKSHSVGATPTPLKKTFGGGIRKTLSLRYSPEGVKKRRKGYELVPTTTDYETECESDGDSSAKDPFASGQDDGFERRIFAGESSDYIAEIPKRHRGFQEPYDWGTRAQNTQNLLAQTEEMDPSTKRAGTRSKFRKYKYDAGLEDKNLGEDWGEQKSSIAGAADTLMAYMSDSSENFSPSSVAQRSKRLSWGQLKTPSKTKSKKRAGKPLPLKKKRNPRSKLLGSTGDTSTGSTVGSGTEGFTVDVAQKQPESISTAHVAGGIKHHDARNDELVRDKTLGEGGLGSSDTLSGCNPPPGPFSVRVDTQSTTYPDALQAGGETEDFRQDNSVLDVGIDKGTRKNASLGTRRIQGNRQDEKGKPVTRPEASTFQGPTRTPRNDTANIVNIAGKKSIGSHEAKPLREKSLKSLLHNTKRRKDVKKIKTSKSKVKTVCEDDDVDELQMDLPGTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWM4</accession>
    <name>A0A2T6ZWM4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1080580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWM4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWM4"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="319" mass="36827" checksum="7B26FD1441B1F159" modified="2018-07-18" version="1">MLLLEYHNLLLKSILTERFNSATASSVDQVISDFDGVTFHISTPETKSKILVSISVKCYSDLLQHGAQQVLEREYGKYITETESGYDFSLMVDLEDLPAEQEAKEDLIRRISLLKRNTMAAPFEKAIDEHHRLAEASKGFNPENAPTGEGTEVMVIRHREEEAMYIQASHDRVTVIFSTVFREETDRIFGKVFLSEFVDARRRAIQNAPQVLYRNDPPLEIRNIPGVKDDGTGDIGYITFVLFPRHLTPQRREESISHIQTFRDYFHYHIKAAKAYMHSRMRRRVADFLKVLNRAKPEVEESEKKEKKTASGRSFRVQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX68</accession>
    <name>A0A2T6ZX68_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_766092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX68"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="18853" checksum="C7C2F1EEFD1D6FA4" modified="2018-07-18" version="1">MLQVAGACIVSEWMDGALGIGLTFRLWGFNLFFNSTQALLSIWHRGVQQTSEQIAIMVYNVPRCISERGSVIVRVQVGALVPKHIIVYLPTYPSEAYPENNRHRRLNHISHEHWTRCLFRERLELNPVVSTLSVPPPLFLSVDDSGSRVAARGVMFGMGLRRKIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY47</accession>
    <name>A0A2T6ZY47_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1123611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY47"/>
    <dbReference type="OrthoDB" id="5405453at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="277" mass="30841" checksum="96C6A187E9720FC3" modified="2018-07-18" version="1">MDMVATAIKRLGSKSDQWLATCAFQKYPEEGKSGLAPRAAKARGNVFNHLSGLLFLFFNTQSHEKMAGTIVKRGKEVTPRRRAWIITLRSLPNPISKDKIKALIGISSSTVNDIWRHAVENARKIRHEAGLDIEEPISLVELVEEKCLDPNLRSGRPEGLTAEDKDCLVETVKKIFSSGQMKLVDIRREAGLSHEGDGTGFRTLASQGIHVYHEEFKPILGPDSKLNRTIAENEQCGGQRWSGQTTGLLMKSPLRWEQFSANHWSGGRKLKGDTTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYF5</accession>
    <name>A0A2T6ZYF5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_974557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYF5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYF5"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12989" checksum="6929CA1DF359A70B" modified="2018-07-18" version="1" fragment="single">SLSPKDIPILRDRLIDWLVRFSSLGLAQLVIRKLCSTLVVFFIRFPDYWDDCIRHIICSLCFGRFVSAAELPQLPPSEILLETAEPRMKITALWFSAILVEEVGKIDSRNVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYG3</accession>
    <name>A0A2T6ZYG3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B9Z19DRAFT_1021279</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYG3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYG3"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.970.10:FF:000003">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="21">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PUU80533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="649" mass="71308" checksum="F484B351A36D40F4" modified="2018-07-18" version="1">MSETRRWTPKDDDVNEDEDEEDSQQYLNQKDAILFAIDVSTSMLAPQELDDGDERGKKGSTSASAVLTALQCAYGVLQSRIISNPNDMMGILLFGTEATKFDTGSGGGGTVGGTAGGYEHCYLLLDLDIPDAEGIKGLKNLIEDPEEFEPLLKPAKEQVSMANVLFAVNQIFTTKAANFQSRRLFIVTDEDDPHSADRALRHSSITRARDLYDLGVRIDPFFIHNPAKGGFDSSKFYDDIVYRSPTDEEDDSQTATSGKMRLKQMVSSIKSKSTPKRALFTNKLELGPGLVIGVKGYLLFKRQEKARSHYVYTGGEKAQIVKGVTTRLAEETAKVVDKAEIRKAYKFGGEQILFTPEEMKAMRNFGEPVIRIIGFKPTSAVRFDMNVKPANFIYPDETGYVGSTRVFAALHAKFVKDEKVGIAWCISRKNAAPQIVAMIPSVEELGDDGVQITPPGFFLIQLPFADDVRQNPESKLVRAPAPLIDRMRAVVKQLHMPKGYIPEKYSNPSLQWHYRILQAIALDEDMPDQPTDTTLPKYKLIAKHAGTYCREWGEELEKLAGNLATPAAKTSAAKRSTLVKGEGLPRKRAKAEDGAEGGGEGDEVTAAWRGGGVGKLTVAKLKGWLEGKGLDTSGRKADLVERIEGALDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZB2</accession>
    <name>A0A2T6ZZB2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1122931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000056">
        <property type="protein sequence ID" value="PUU80806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZB2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="28603" checksum="23DDFD4955384F67" modified="2018-07-18" version="1">MLMLILILILMLMLILILMLILILILMLILILMLMLMLMLMLMLMLMLILMLILMLILMLILMLMLILSFAFIPHHPILSQFTKIQNQKTPGSMAPRCSIDFRLDCRAAGIVNPFTGVSSDPGISSTSTVSPGGSHPSSITSSSNAQMIGGPSQLPPLIPSGGPSMDDGEGGWPYSGSERWGSEVMELEEFESTDEEEGGDAGWAWSGSEYWSDLPLEEYESTNGEVSEGDAELEENTTGDGDHSEETKGVEAGIEDQMDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZD0</accession>
    <name>A0A2T6ZZD0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_686479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000056">
        <property type="protein sequence ID" value="PUU80823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZD0"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="193" mass="21347" checksum="922BD469C5659C81" modified="2018-07-18" version="1">MRHQLGLVRAEVDLIAHSLPAELGPLPLHLDGDGFYSVLGPPLSHTIHEDQVNESTGGSLAYSHINTSAPLMPPRSKVFCGSLKCSGNSGPHTCSRRSYTCNAPSCTRPTPFRTKQALNRHYEAIHLAVRFNCPVPGCGNNNQNGIKRYDNLITHVRNKHSVSLVGGSWEKFSPQERSARTLRRISLEHNFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZD2</accession>
    <name>A0A2T6ZZD2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1122873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZD2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="20251" checksum="7EF9002FDE36B250" modified="2018-07-18" version="1">MVKIKPTKCSAVFIAKESVVLLKTIKKNLALEAKISPLRHHVSVCPNCTGKGELLGDVVAKKVEPEDATEDVADNRRDFEPACEEVTREGMDVELIMAMEIQGEAERPELQVAKPMLVVIDWYNRFKLDLLSYNQDESIQNSTETPEEAVIVREDSSDLETRFERIVELFKRDEDMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZD7</accession>
    <name>A0A2T6ZZD7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZD7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="13023" checksum="AC235C4A47F1473B" modified="2018-07-18" version="1" fragment="single">MDPRYNRNSKCLVPVASVGKSIGPISLLFFFLLKFFSHKTLIFLFLSSFFFPYYGNRIGSWLVMHYRIAQDDGRREREKCASGRFWALRSTKDKTRQGSRLFVGLFSSYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1C5</accession>
    <name>A0A2T7A1C5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_590284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1C5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1C5"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="206"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU81540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="303" mass="32681" checksum="F6B365AD22B60996" modified="2018-07-18" version="1">MADHVPPQDVDYESLGGGSLTSNLVAGAFAGVMEHVVMYPVDAIKTRMQIVNPTPAAMYTGITNAVAQISSTEGVRSLWRGIASVAVGAGPAHAVYFGTYEAVKQKLGGNVGSEHHPFAVATAGACATIASDALMNPFDVIKQRMQVHGSTYESIADCARSVYRNEGFRAFYISYPTTLAMTIPFTAIQFTAYESLAKVLNPTRRYDPFSHCLSGGMAGAVAAAMTTPLDVIKTLLQTRGTSQDGRIRNSKGLLDAAKIIHEREGYRGFFKGLRPRIVTTMPSTAICWTSYEMAKYYLRLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Q3</accession>
    <name>A0A2T7A1Q3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Q3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="69" mass="7587" checksum="4B568CDF6BB10AA1" modified="2018-07-18" version="1">MLRAIFSSPNAKESLSIALASGAAYWVAIANTKRICRAEEEFRADLRFIEFQDALTKSAGGEGLQLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2Y6</accession>
    <name>A0A2T7A2Y6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2Y6"/>
    <dbReference type="OrthoDB" id="5407713at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="153" mass="16284" checksum="FD6778F81DD125CC" modified="2018-07-18" version="1">MELLTGLEISSEDPSLIDLDSDLQVNDTTRAPSSSLGFFSDIVGEVEGLLNTQPSQTPSLLDGAMTEDLSLSPDLDGLPLPTPQGFPHLNTQQVVVEAPREDRINEAQLQEPLSDSQHNSQATSIHGEDSAESTVEDVAQGIDSENTDQAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3J1</accession>
    <name>A0A2T7A3J1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_467075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3J1"/>
    <dbReference type="STRING" id="42251.A0A2T7A3J1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="23147" checksum="668CFEBFF83BB655" modified="2018-07-18" version="1">MAIYSTGPRSAFSDSSSSSLVARPTDKSFLKRWFNRGKPRAATIPISRSTFDLSEKYARRENELFALPPSPHTHPLLSKPYARDELRPRSSTNYSRPDGSIAAGGDGSIHARKAALMRPAGRSVDSGVSPEREREVNARGIREREKAAREAAVEGKYVQEWGFFVKCYAEGRFNVSNPPDPPPRRPDFDHLTAPLPPNEKQRLEAVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3J5</accession>
    <name>A0A2T7A3J5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1061917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000030">
        <property type="protein sequence ID" value="PUU82312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3J5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3J5"/>
    <dbReference type="OrthoDB" id="5477555at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="136" mass="14884" checksum="CC93EE92D6E406DF" modified="2018-07-18" version="1">MGSSEWCILLSASDLKASGHDTHREQDPISVEESVSTLRTRVCLGEAPGVVVHLRHVGDLQILEVISDIEFPPLIPSEKRSLIIKAHPGNPTALTVIDIEGEDLINDCSAVKQQINSIQVDFGIYETPLLTVTLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3U7</accession>
    <name>A0A2T7A3U7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_415466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3U7"/>
    <dbReference type="STRING" id="42251.A0A2T7A3U7"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="108"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="451" mass="50999" checksum="51F699E790A7CECF" modified="2018-07-18" version="1">MVLLAPLRASARVGVSRTRLPPPPLSAARYFASSVIARQSAPVKQRLHSDSVLFPGAVNSKFTNELKFQRPQDLPAIPTYRLIDTHGEVVDKSREPDVSQELALKMYKDMVTTSIMDLLMYESQRQGRISFYMVSAGEEGIAVGSAAALSPDDVIFSQYREQGVMMYRGFTLDEFMNQLFANKFDYGKGRNMPVHYMSEKLHIHPISSPLATQIPHSVGAAYALRLDQSSRIVVCFFGEGAASEGDFHAALNIAATRSCPVVFICRNNGFAISTPTLEQYKGDGIASRGVGYGIDTVRVDGNDIMAVREVTMRAREMALKEQKPVLVEAMSYRVSHHSTSDDSFAYRAKVEVEDWKHRDNPITRMRKWLECKSWWSGDQDQELRTQVRKDILKAFARAEKEKKPALENLFLDMYKIPGRDLEEQMAELRRIIEEYPDEYDLEAFDRGKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4W5</accession>
    <name>A0A2T7A4W5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1120167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4W5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="19100" checksum="D815706DD5C47246" modified="2018-07-18" version="1">MPITTPEHTKEPPRSNHRNSEFPYANDAWSDTAILWTVDKILSYTPHYYWVGVKSPIWGLKITPRLSPTTHHCKMSSDQYDLARANHEIEVLNDRILELENLIIFLRIQPMESNLYNEQPPFKEVADRLEATKEGLIGEREELMGLIERLKESLRGRRGGEASSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Z8</accession>
    <name>A0A2T7A4Z8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1074211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Z8"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="20558" checksum="F29634B93CBCA290" modified="2018-07-18" version="1">MALVASPDGLAAAASSTTLFHCQSDPPTQDGVYTTHPTSCYFTHTPNHSQYPVRPKQQPANGLQEEEPHPDLNAGSLVSSLPPPLHQPTYHGEEGGAVADQPNPSPHECSCGATFGRRTDLERHQRTTRKHNGDQHGRACPVKGCRLTSKFTRDDNFRTHCRRQHGMSADEVNTYIRRWRSRRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A564</accession>
    <name>A0A2T7A564_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1120108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A564"/>
    <dbReference type="STRING" id="42251.A0A2T7A564"/>
    <dbReference type="OrthoDB" id="5298104at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63611" checksum="A866B2654739139E" modified="2018-07-18" version="1">MPLTMLPPQLLQTIVFTGQLNISDVASLRLVSRAWNQAFTSTDFCRFCLSHFFPFAPETCGIGEAGTALGSFNMVQGRLHRLRSKQWALQREFSFALDPMSDDCFSPDNIRIIDLDSDKGYYLMTESDSTTVRVIVKSLVSGQQVLVTVPREELNGIYMNEGKVLLVYGRDRNRGSSMFVLADCRQGGDGRTIWSASVSTPVFPGIAGLASTAADGRRRLQPLFNDHYIAFLSGLRGDGTSSVMILRFEEPSSPESTSAGLHISPLRVSPQTLISIRPDTVGKYLLVAERFLHQDNLHRVVLVNALSGESLRAYHFNVSPLFKLIPERDMDMFFTPNQSEIIIYGSVRSQEYRQGGIIGQVMVAKIWGNGGAKIRYLRAPADGVVPDTVETKYCPELGLVWHDEGIIAFNSLNLLSPTAGSGEFLNSHNLCPILWVSMLPTPTKARKKLCIGKSWMCAEFNAGSFGSVEVCRIAEPQLPGSDYNQSGSLRSSWILETTTTENSSVGFEMGEEPPRALQVDATQLAARLREELGRLKEGEEEKSGSGGGERLGWRQKINWEGKRTWKERLFSWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5N7</accession>
    <name>A0A2T7A5N7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic integral membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1073728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5N7"/>
    <dbReference type="STRING" id="42251.A0A2T7A5N7"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="365" mass="39452" checksum="83EF6EBB32D2B6CF" modified="2018-07-18" version="1">MPPRVNIPPLTRGCLVACVFLSVLTGALRYRDQVARQEEYPDSPTGRGSQIYTVPYLTVVPALSIVFPWTFLTAALVEQNIFTLVITLATLFYGGKYLERAWGSREFGKFLLVVAVVPNVIAFLLYIVWFALTRNLERSFATICGGVAAQSAFLVAFKQLVPEHTVTLFKGLLKIRVKHFPAAFLFLNTLSGPILGTDVSTTLAWLGFFSSWTYLRFYKISHADLSTNQSPTLKGDASETFAMAYFFPDPLHRPVAIISEVVYNLLVSFRICTPFSAADISAGNSRAEARGDASLGMLLGGGRGAAQPGSARAEAERRRAIALKALDQRLHAAANKPPGSQAVVNGGGNGGVLGETSLDTEQAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5X8</accession>
    <name>A0A2T7A5X8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1 8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_211569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1 8"/>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5X8"/>
    <dbReference type="STRING" id="42251.A0A2T7A5X8"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="124"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU83110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="478" mass="53163" checksum="22FF1631032FB77D" modified="2018-07-18" version="1">MRLSSSLRGEGRIKNYRDVSSKLIFYDLVQDGEKMQVVVNCARVGGEKQEFRRISMLTRIGDVVSVTGYPGRTKAGELSIFATAHLQLLAPSLHAPPQAILDPETRFHNRHVDLMIRPQAGQILRLRSHIIQHIRDFFISRDFVEVQTPILSDTFGGAVAKPFLTEATRAYRGKQLALRIAPELWLKRLVIGGLDRVFEIGAQFRNEGIDNTHNPEFTTCEFYQAYAGLEDIISTTEQLLSSMARKVSELKSGKLKDLPEIGTDFTAPFRRLEFIPALEAAMGHKLPILHENTETVTQELLSLFETLSIPTPPMLTIPRLLDKLSSRYLEPQCVEPTFLVNHPEALSPLSKTSLVHNQRVSSRVELFVNGKELVNAYEEENSPTEQRRKFVMQAGWKDDDVIGGGGDEEGVDEAYCQALEWGLPPTGGWGVGIDRLVMVFAGAERIAEVLAFGGLKGAVNLGDGARSVNKKEVEEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6W9</accession>
    <name>A0A2T7A6W9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_963506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6W9"/>
    <dbReference type="STRING" id="42251.A0A2T7A6W9"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="279" mass="30392" checksum="029AA12A2715EB1F" modified="2018-07-18" version="1">MTKRIVALSGSVLAKPATAAASRRASAMETTHVTVAIQMIKDKNPPRGYIETLESRCIILTQGLIEMDRIRKGLPPSSTQFIAGRPSGRLANSILKEIGIDTSRIETDFDDYDGLCGGGSPGAESLGGGSNHSQYDEFFTSTEHLSHPQSHHSPASSRSPSVNAASSRTWPLEGHRRQASHGYPLANSQFIADRATGQNLVSNGDYQPPMLLMEGTQYQPSSPAPGVFHYNQDYNLSSQDLPNDFGEYYEYNDNRSPTGSSTNVTCMEPNYNFHVQGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6X1</accession>
    <name>A0A2T7A6X1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_49237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6X1"/>
    <dbReference type="OrthoDB" id="5314485at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="319" mass="35467" checksum="5A925C00794EE3C1" modified="2018-07-18" version="1">MSSPQIAISNPPGLLSNDDQDFINQWFTHYGFSFSNPEDLAARLTGLKRTYKRRTPNRALRGNCDGLLRILTHIASLRNHRHRRDAANIVSQVDARLNRGMVETLVPDPTRYRRPRPRAAISALANDPLPDEVGTLPPARGPGEPIPEVSVRRTFPRYTRAPPTLPAENEDLADGITRWIPETEDFMTAMLNLRIMGANDPGLHAPLLVDHPLEVVMEFPETIALITAPVPQVDPTLQTAARSQLTIYDTRSGAPSRRGALTPDHYIYKLVDFFRTRLLEPSVAAKYAIVNRSHPSRYGPGSADNIAHEPPATVNESMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A804</accession>
    <name>A0A2T7A804_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1071434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A804"/>
    <dbReference type="OrthoDB" id="5366363at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="707" mass="78383" checksum="D9DF5EADD18B6C07" modified="2018-07-18" version="1">MESVLQFLRKSRREIHGSFESYMSKEIIVPCRSCEQYVPIKVIGVLLEPDKAIEFKCNCSQVVGFTRSPQAQIYSPPSNWQPDHTPATQFELDSEKRVIYSDPVSIGSQIYIAETGHAANRNSNSHNELRDDPEPSPPSRNPTPSSLKGKQKVPARKASVSFSEHLPTLHDTSSDRNSTEYFSEDGSMDGNPRSRQSSVSLPRRPSSGFRHHDNMGFDSMADKSIGRHSWNSSRHSFIGPAHRSYSPAPPIPPIPRSTTPTSGTISRRSTLNRGSGDYTMGLSASPRLSTESNSSQDWQNLQTNRSSLDSEFDQKREPPAPIDRNVSGKRRTESQRSLHRVAVSRRQSIRLENEDESEAMTSSIKRRDSMGSDFEVEPSDEQVRHATQIWNERGKHDSADVQWARDILKRHMSWRKNINSKYLNPLQANRGSVERFQVRPGNADEGPNSSTNHPQQPHPLTIPVFSGSTPGFTENNIPTPVEEEPDSAGHRYGTASNRFLQEPGIPFGRDPRSSEFSPAGASQANNIQAKFNDFGGSTPASGSSTPHREATPSELPKPRLNPRYVARRLRRRCRKALKAIACKISSFRRMSSRSVAQAPTVVATAADCPRQDSDIDPRAPAVPEDLEPTPTDQDLEMHEAPPDGPAEAEASTQVYSGEIIHNPSEEEVGRVASEIVLTIDGMVAPLIELEFEATPLQLGFTTGQVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A870</accession>
    <name>A0A2T7A870_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-ornithine N(5)-oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_708103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A870"/>
    <dbReference type="STRING" id="42251.A0A2T7A870"/>
    <dbReference type="OrthoDB" id="412005at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029731">
        <property type="entry name" value="OSGIN1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192:SF8">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15192">
        <property type="entry name" value="PROTEIN CBG05349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="55863" checksum="7D1384E0136B4FCC" modified="2018-07-18" version="1">MAPRRFTSSNHIPPEDVKCTDTVIIGNGPSALFLSYLLHGNIPTYDSVTHGPHPDPALHTKLSRYGNRPLFDAIESMRASEALTEHFHAATYMGYSNQALPLNVLLDTLVQPGADTEIGGAKSRLKWSSDERRRIGHVVLGSAKEAGGQWSEDPASTGTSWDIEALSYAEMLSLPGYSFREHYRRKHGKAMPHLNRPTRREVADYYGAYPRAAGISSEVFSSVYAHRVNRTQSGFSVKVYRKPTSSRPQCEYTIHCKHLVLATGILTNVIPPPPIFLPLLNPANNTLYQQQRVKTLPLLVVGSGFTAADVIINAPPNQKIIHIFKWNTTRPSPLKGCHSQAYPEYASIYRRMKQSAADSTSPASLTTPSNYEGFPNAQVIAVSGDGRVIRILTADGDILERTIDTLNYCVGRRGSLEYLSAELRKAVGVLDAGWVSADTLRRRAEADLEVTKNVWVVGSLTGDSLVRYAFGGCAYAAGRIMADQEIPEDELTMQEATTTSRRGSGCVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A896</accession>
    <name>A0A2T7A896_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1098358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A896"/>
    <dbReference type="STRING" id="42251.A0A2T7A896"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU83949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="55170" checksum="C33C4436C5234910" modified="2018-07-18" version="1">MTGSFTFKWAQPAGEVYVTGSFDDWGKSTKLNKEGDAFIATVSLPSEKILYKYVVDGNWIVDTTARREAGGDGIENNVLLPEDLVEEKTEPDMSSAAVSSVAPDSTTAALAAQVPKETNGNVNDAAISSVSPDSTTAALAAGVSGEARTPSLKDVPGGFPQTSAIETSDPHEDAEQVPPSEPAPKHDDNSEDLSGGVKLDLNSSPEADVPEIVEDSQEKADVPPEASASAEQKKEVEGELKEGVPVQSSAEGDVAGDQATTVTPTVGGIAAAAGLSSASGESNEETTPTVVPDLVKQSQEAAHVSPEASAVESAVEAKKEFESELKHKGSPVSPPVKDIAENPVQLNTTDDAAASTAPVPKLEVTDPQEATTPLSPTTPVEPTKNGTPKNGSPRKSIENGNGEPPASPTQLTKKKNRFSFLGNLKEKLHFGKDKGKSKGVVPIMIRKVHVLLFLIVFLLIRQTVIHTQRTMGREGKLGMRALWNSVSVVALFQSCMGTVSGLGSRVWGTIVPAVRSPLKFFHLSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9M6</accession>
    <name>A0A2T7A9M6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1070329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9M6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="53" mass="5833" checksum="8DEE6CE51A515605" modified="2018-07-18" version="1">MSASTKIWTTIKAFGKWAQKNPTLTAGFGGTGLLIANERTGRRDVKDAFHPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9Q4</accession>
    <name>A0A2T7A9Q4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatase 2C-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_960738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9Q4"/>
    <dbReference type="STRING" id="42251.A0A2T7A9Q4"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="554" mass="60373" checksum="5E5C80F9F59AFB41" modified="2018-07-18" version="1">MNTKKLSLALLSGLVLTGAWYYRATLLGASETGFPIAGESSSTPSTTTTAAGPGATEGPRKIVAVDNESVYTGTLSAGPGGRVSKEVENNNGEKVVEMLTPEQATSKLRRNEESYFVGRGKGVWRYDVVQIPSNDPIEDDHAEKIIEVPPTIVPAEEGQETGPSDWMFWGVFDGHSGWTTSAKLRQVLITFVAREISNTYKAAVADPASKAPSPESIDNAIKKGFLQLDHEIIHESVDKVFKNPSKLVAAETLAPALSGSCALLAFYESRSKLLRVAVTGDSRAVLGRRGGNGKWTATPLSEDQTGSNESEAERMRKEHPGEEYVVRNGRVLGGLEPSRAFGDAFYKWSYDTQLKIKSQFFGRTPSTLLKTPPYVTAEPVITTTRIEPEKGDFLVMATDGLWEMLTNEEVVGLVGKWLDDQKAASKDGKPWFGNWFGGGKDQGMLPVETATNDATGQRQPVRVKQWGVTAKDSERFVCEDRNAATHLVRNALGGKNQDMLCALLTLPSPYSRRYRDDLTVEVIFFGDNTENNGQVTINKEATATVKSETPQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9M4</accession>
    <name>A0A2T6Z9M4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000672">
        <property type="protein sequence ID" value="PUU72197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9M4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="72" mass="7707" checksum="71F1AA07380FCFEE" modified="2018-07-18" version="1">MEPPNPEIDDPKPIAKTKTTQSEIKKQSLSGEKEMIPARTSNRDAGVKAGGSAREPVKNIPRANGNPVVVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9U6</accession>
    <name>A0A2T6Z9U6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1138311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000606">
        <property type="protein sequence ID" value="PUU72268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9U6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="125" mass="13707" checksum="C192E984A6BD80F6" modified="2018-07-18" version="1">MLTEFPTPPSILSHSMPLIRTTLHTPPSLVLGSFQTLNLYQQVPTCIAFVDQHFKGTPEIRNPIHNHPHVSYQLLEGRNLLPQVSKLPFEPPKAPLLIIKPLLELGGTVEAVTGLLICCEGGGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAN6</accession>
    <name>A0A2T6ZAN6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1137296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000509">
        <property type="protein sequence ID" value="PUU72545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAN6"/>
    <dbReference type="OrthoDB" id="5475159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="13195" checksum="A40F1B19ECF14A14" modified="2018-07-18" version="1">MAPGYLWRHLKRPGVCGRIGDEKAAWRNLHRIEHDRLLPTRITRAERRREANKAKTQKKLRASKFELRARNMGITEKSLIAQKVAIWEGTYAAEQSRDSIGVGIPYSIPFWSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAZ4</accession>
    <name>A0A2T6ZAZ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17/PMP22 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_637285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000486">
        <property type="protein sequence ID" value="PUU72670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAZ4"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22977" checksum="CE0E6F3346A96389" modified="2018-07-18" version="1">MLTWYRTALTKRPILTQCLSTSFLFAAGDVIAQQAVERQLDDDGRPTHNPYRTLRMAIYGGGVFGPLVVNWYRFLQTAVRIPTSPNLEIVSRVALDQAVFTPVNLTLFFSSMATMEGVMGDDGKKGLVGFGTRERVRKKLRDNWLQGLKANWTVWPGVQLVNFRFVPLEHRVLVVNLVSLGWNSYLSYLNQQGKGKEKGREVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB55</accession>
    <name>A0A2T6ZB55_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 6">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1136857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 6"/>
    <dbReference type="EMBL" id="NESQ01000475">
        <property type="protein sequence ID" value="PUU72728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB55"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB55"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="191" mass="20422" checksum="7C74A61FCBA2AC1B" modified="2018-07-18" version="1">MKAIVQRVLSASVTVDKEVVSSIGQGLLVLAAVAPYDTPKDVEAIANRILKLKVWDDEGGARWKRSVLDLDHQVLLVSQFTLLATTKKGNKPDFHGACSPAVAREVYASLLQKTRELYVQEKKLSPEAGATKVQDGVFGAMMEVSLVNDGPVTFEISSPTKQVETPPGEGKTQGEGGPKLPPDGGELDKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBD5</accession>
    <name>A0A2T6ZBD5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1059167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="NESQ01000462">
        <property type="protein sequence ID" value="PUU72807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBD5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBD5"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="421" mass="45825" checksum="63EC30E37B9D79C8" modified="2018-07-18" version="1">MESGPVVAYAGVDATAPSLHVGHLLPLINLLHFYLHGHHVIALVGKSTASVGDPSGRVVERDSIASRRLDESFNGLWAQIEKFFERGREYAVSKGYNEANFGKRKLKTNAEWLDGLGLVEFLATVGRHIRVSSMLARDSVKDRMNSGNGINFSEFTYQLLQSYDFWHLYRTANCRLQIGGSDQFGNITAGIDLISRYQPGSTGEATSSAAEAYGLTSPLLTTESGEKIGKSAGNAIWLDENLTTPFELYQFFATLPDTHVQKYLGMFTLLPLSEIATVTHAHTANPGSRIARNLLAKEAVTLIHGIEKALEAEFVTNLLFPVDGEKALSAAEIISVWGDRVIKIPKTEVVGEIIAKLARRVGAVKTRGAAENIIKGGGMYHGLKNEKISDGMATVQEGWLVDGEVLLLRVGKGKFTVIQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBL3</accession>
    <name>A0A2T6ZBL3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1136434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000447">
        <property type="protein sequence ID" value="PUU72881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBL3"/>
    <dbReference type="OrthoDB" id="5419633at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="170" mass="18440" checksum="8F67955CBFA7B241" modified="2018-07-18" version="1">MTLVRAGLRQTIENPGYSAPAGIVTDRFRSISIERSSTRNISSSGDSSVFRPYCIQADSPSWIARDESLQYHQSPEDALVFGMILGIAHVVDGEIYQARVRARRQVSRGLGEDGDDNDGGFVEHFDEGDFTGDEVRLSSIGGGYYAGESDSGDMSAVTHVSTCRSHSART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC10</accession>
    <name>A0A2T6ZC10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1069348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000434">
        <property type="protein sequence ID" value="PUU72976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC10"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC10"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="43"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="58302" checksum="D36368649BEA9C00" modified="2018-07-18" version="1">MGEAQSDLVEWYKLDTEFSQDRVRHTKYMGKAKNRNKKVKEEWSDCGELGKGGFGVVHKQIRKATGHYRAVKKIDKKLPAKIDYSRELLVMAILTKHPPLFVEFLGWYEEPETLYIAMEYLERGDLTKHIGSPLPQETVRNISKQILEGLEVMHRHGIAHRDLKPANIFVVSMSPVWIKLGDFGVSKRILAQATTTLHTQVLTQVYSAPEVLGLDSNSETSDYTNSVDIWSLGCVIYELLVGAKLFVSEFQLYRYFYGIWPFPEDRIKGVSLPADDIGISLLKAMLSIQPEDRPTAGVALRHAWLADLKCDNEHSGDDGAKTIQSGNRNMPSMKCESRLATNGRPKKRKTRGDPITQDDTKCTRGGVALGASPGSRGASDLATAKAPIDTFVMAPPDTSAEISAAQMGPQIFEPMLPNFFGPRLFGLSGEIQVCDIPLRLKTPPQAPSQDLTPIKEMIYNRLQGQMAPSGGDGRNRDGTTINSLQNPNNMGNPDANGYPDRDPNAGWNLCQNPKPGFNSYRNPNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC28</accession>
    <name>A0A2T6ZC28_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1006250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000419">
        <property type="protein sequence ID" value="PUU73052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC28"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC28"/>
    <dbReference type="OrthoDB" id="5398391at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="54" mass="6421" checksum="5A9A748DBD6B2624" modified="2018-07-18" version="1" fragment="single">KRAFVNGRSRQIIIKNMEKRISRWDFEAEKEEATQAMCDIARDRAKKLTPQRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC50</accession>
    <name>A0A2T6ZC50_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000422">
        <property type="protein sequence ID" value="PUU73039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC50"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="19811" checksum="18B4C1DEA2B32E46" modified="2018-07-18" version="1">MAIMDIKSIITIFHITIAKNKKKSYRIKQLLQALLASIKHNKIVFVASTDHPEHSKRRQKVPELATVDTYRINLTIEQFQLMFSNEIIHDIMVHLPFDDYTKDLDQLFSSISGEEGEDFSEAEYEEDKVLDSDNVDDSDGEVGNEPDILMEEEFNTDDGSNININDGSNIEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC59</accession>
    <name>A0A2T6ZC59_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000416">
        <property type="protein sequence ID" value="PUU73078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC59"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="19468" checksum="9C49B4E2A5AD6A9D" modified="2018-07-18" version="1">MSSLQDQAIPGSAREFTAASMTEVVDAPIFNIAAQQSHIRLPEVHILESLLAVFWRDLRGALVFQERLKNAQTQWKWLVENPPSVPTPGQSGNGGGWRDEGASGSTTHVNRSTAAQRLVALAEEFSTPLSSTPTFVNTKAKAVLRNSTQALGIVTKDMLTSANGGSNSSSTDKPSDLCTPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC69</accession>
    <name>A0A2T6ZC69_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_942107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000419">
        <property type="protein sequence ID" value="PUU73059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC69"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="193" mass="21107" checksum="185AD2E48B2BFB6E" modified="2018-07-18" version="1" fragment="single">EIIVVSISDLHTIPLPKVHIPPGDILIVAGDLSEGRPAQLMQRLSELRALPHKFKIVIGGNHDRALDQCRAAFRGAKGSGLFYLEDESTDVTIGRRTLKIFGSPKSLASSTNTAFGYTEDDDFSSWGTVPPDVDILVTHGPPAGYLSDEKNGCDELRKALWRVRPMLHVFGHVHSSYGTTPLSYDDKQKASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCZ7</accession>
    <name>A0A2T6ZCZ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1163740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000392">
        <property type="protein sequence ID" value="PUU73284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCZ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCZ7"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="132" mass="15127" checksum="99932BB070A96A60" modified="2018-07-18" version="1" fragment="single">SLLNIRNSEYSAAYSLDFLDRTKFYDTFALRDINGRPAASLSYPFSESGPPRNALLRSRPVPRSCWDGMVLFEAAPFLPPLRSVSDSLAEWHAEGSECCLIHYNNPALIKASGWIRMLEWRIERRDGNWFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDV6</accession>
    <name>A0A2T6ZDV6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1134715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDV6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDV6"/>
    <dbReference type="OrthoDB" id="5362656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="709"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="866"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="894" mass="97220" checksum="0475A077F5609EBD" modified="2018-07-18" version="1">MSFPTILTSSYSSPQRTKTQRKPPVSLANSTFSNSAPFEDDERWKLLISTNSMVRVWGRDGCNHVFTSGSEGIVAAKGAKDGSVLAIADAQVVILRGIEEGRNKSYRLKGAQHCRLLQYDHESQSLFFTDSIHNSVQTYSLKENKVFDSTKAHPSTVVSFAISCDSNLILSCSANPPAIQVHNRLLATTAAVVPRASTSSVNICVFHPTRRNIFVLAFNDGVLAAYDYSKISGGAGARRDDRVGIGQGGLKEIHTFRHLHDPSVAGSSGITGVQFLPGYRSRAVTVGEDGRAFLVDFGMRDTLGSWHIGAPATSLTVRSTAAKNGDQDDPKAYLIAVGSVHGRCYVYDGHGNKIGEQVVDAEGGKVLGVEWVTGDICIPLGSGTCDPNLYSHKRSRSGSEPPAKVREGLRTRAGSRITTENRNPSRPSERQPVTKGKDIGDSFPKLGIEGEPEWNDVEETVNQGYMRLFSPVKKKRSPRALSVDEKKSTSAEQCLDPQERVRKMETQQSSRSAPPLCNELGEKTPRPLAPMIGNDGPAQTPNTTTKTEGKTVHKQGRDWRYTKTTQPSVTVQHVSSGTSKGQPVTDKARDGKLLSDIRSVRARVMGQSGKPVRGNLALFAPYMLGKSKKERPQSPEIVRETRGSPGRPAAGPRPETSNSARAVGGIGGSRDEGIATMQVADETVTTAADNEATDVDDGSFEADIWLVEGKEARRSRKRKQSSADQAAETLLGLDDSNGSRRSLTGSFKSRKTVSWQDETRTIRDISMLHDTKDLSFLPKPSGSGSPKPKSSSQDVSSPPHRPPTTGSFSGSAPFSPLGIRLPGPENAELRSALRSMVMEMQIAFKSEITDMRAEMSERFRQQDVLLRNLSHEVQMVRQENQNLRHQLSEAADMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE35</accession>
    <name>A0A2T6ZE35_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_899120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000348">
        <property type="protein sequence ID" value="PUU73758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE35"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE35"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="53" mass="6103" checksum="43A5762C9A5999C2" modified="2018-07-18" version="1" fragment="single">LYIAMEYLEEGDLTKHIGTPLQQEIVQNILKQILEGLQVMHRHGIAHRDIKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEB0</accession>
    <name>A0A2T6ZEB0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1094326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEB0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEB0"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="153" mass="17531" checksum="3F389E10BE8BB6A0" modified="2018-07-18" version="1">MSSRLILSFFPPPRLSLLLPPLTRTRTMQKYFTTTPTNRQNDEPPSSPPTTTTPTPKDLTQKLTDSLSNLSPASLPEDHVSEQDLQKLQSRFFAGDIYAPHDLSHAQQRSRRLRRSPRFDVCDLVGVNPVKEYKVGYVMFSFLFFPHFLYLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEM4</accession>
    <name>A0A2T6ZEM4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1002300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000335">
        <property type="protein sequence ID" value="PUU73896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEM4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEM4"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="160" mass="18285" checksum="B4D5467C0D17D1D2" modified="2018-07-18" version="1">MQLLFYYLLRARPFLTQHGTLPRFIASKGTPRRLSTPTFGKAQAPTNEPQWSSGTDEATKKEALELISGGKWSLSTTRMGIEREFKFKTFAKAMAQILFINQIADQCEVKKHHPEWANVYNKIAIRWTTHNPEGLSYKDVEMAKFCDDKGTELGETERGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF58</accession>
    <name>A0A2T6ZF58_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_483068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000322">
        <property type="protein sequence ID" value="PUU74109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF58"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF58"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="154"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="459" mass="49641" checksum="622EAE6671C2D438" modified="2018-07-18" version="1">MPTPKAHAETHQSTGRAAYSSGDYATALTHFTTALTQPNLPAALRASILDNLSATKEKLGGEANLTDALNDARAMIRLQPAGAEGYLRAGKVLQLLGRDGDAVRLYEYGITKLPANGGGGSGGGGGRARLEAQVGKVRSRISRREAISNQRKRRDPFTALPLEVARMVLLHVPFRMLMLARGVSRGWKVLIESAPATFDTLDLREARRNVSCGAFKGLVHASRGGVRVARLARLGTKCGDLLRYLVVRCPGLSIVEIRQSEADYALVGAVRDGAIRGLRSLVLDVELDVIEVFRILRLCVLGGLQEASFESVHVRVAGLVSSDLLDENAPLHSLEKLRIDIPESGRYLIIPLSTLLKAFPSLHILELPGVSIFPHDEHLDFTPLPHLTTLHYSQPGRPAYPILPPSLTSLTMTEIFTTYTEPDLLSSPLPSLQSLSFDTSPSLTVESLTTILSPPPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF67</accession>
    <name>A0A2T6ZF67_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beach-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1093596</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZF67"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1742"/>
            <end position="1875"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1913"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2293"/>
            <end position="2333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2340"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1649"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1064"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1079"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1709"/>
            <end position="1730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2532" mass="283173" checksum="B372902F4C2324EE" modified="2018-07-18" version="1">MSTSSNMASAASPPSASTRRRVSSAASAKPKFIAEIKPLLDSLESSASDPDILVRLQWLSLLKRNLVDSPEAKDTFRTLKGFNYLISALHSCSGFYTSENRTDEEKNHFIELIKCLFGVISEALLNHPGNKRFFARRIGWDSLEQGLAATGLPTEAPDQLFGLILAFAMDDATLSSFVVSVKRGLASDGKSGQEKQAVDKVRAKVRGSFGSKDILVNAEITPLILSFQTAMAQTEESKITTVAVLQALLSIASSSKSNLAAMHSTGILSTIIPRLWDASVPELERAILKEFAQYLMQLGINCLNDAKYLYRQAMAHDAVASFLLQGLKISRTPPHVQFDLSLHGYASMEFSSIGRSFPPTHTNGFTFSAWICIDTFDPTMHTTIFGVFDPTQRCFVLAYIEQDTRKFILQTSVASPRASVRFKSTVFEPQKWYHISLVHRRPRTTSAAKAALYIDGEFVEQVKAAYPQPPPTSSTPVQVFLGTPSDLSPRIGQGVVSSRWSLGTAHLFEDVLSDDLIAVHYRLGPWYYGNFQDCLGSFQTYEASAALNMRNELMHPGKEEKSDIISAIRSKASAILPEAKVLLNLSAQQILDDKNDNNIDESQLAKALSRPALKNLQSLTRGGAVAINGAIPSVSEALCLTHGVAIMTGEPVVIVPQSLDDAAWSIGGAAAVGLKMVEVAKTAKQVCRAVEILFEITKGSWRNSEAMERDNGFAILGHLIRTKEGKNIIGKDLLRVILEFVGFKHDAPEESFIINPLAYRILLVDFDMWRKADTETQKEYFAQFVTFCNGSKYHHFNSKRLFRMRIVKKLIFALKGEVFSREVLPDFMAAFKALVKTNMSADVLRSLALFITYSLHKNNPAKPLRVKKSNVQLRRQPTLGVGIAGATLSPVKSMNDLSSDGLTRQQIGVMVLEMCQDLLFEDGNGVGNIKKFARTVTNKWLLYLLAESDPKVVIIGAKILARLLVVHGGSYVSKFGLKTGGFIAMRNRLKRWWNVAPLWPVCFAIFFGKDVAKIDVSRPLDLFGLAEMFSDAGSGKVAYPEMLPVIAGMLKAGLGAIVADQSEEGTRRSSDKKPDDGKLQTSKSPRARSLSLSDKSPQPASNKIAEKRLGELAGMLNTLIQFFAHLHTSCPAFREFCATSSFIKEMLGILFPIVCSSDHVSAETELNSKDSALTFDGGDVVIRPLVSNAAPPIVRTVTVDEPPSPTAPRSDRLRRGSSFILVTSEPTPYIPSSARLSPAIGPGLRNSGSAVPGPSVSNSVVESLLELVMTVFSDLVLERREFTGFGLSTKIPPGFQEHQIYFETYLLRNTLNHLSNILGFDRKKLCEPRVLTSIGRFAAHMTDCVYEGWFLNGAENLLDFVGTILEYLQRPEVAKQKSVRLCSQTVASLRAVVSRLVLFRLSELDDPKSDSQQVVGFLGKMMYWQAVILSPENTEGEFTRLICYLLYTRLIDQQQDIKLAAANMLRIVLVQKPAETSALLNQAKTIDHKQLSSGFRKLMELDSGTWLDWVDDHREDLDAFFYGALSKAWESFVAEENKKTTETAKARSSKRKEKLKQWILEDMNNEDVYHRHESASSHWMVNIYNSEHLKFQRATQDQQDSLSYVISSYSKLETDLMRPCGLLDDGQETKWRLDLTEGRNRMRKRMLPDSSAHLHNYQPKRRLTGGLGGNAGPSKSHSLSVEDDEISIITTRETDSLDQSQHNSARDGGEDDFEEDYELVDDPREDDDGWEDKNRKVMRTIQHGDVVEYVQNVSRLVGLDAVEGLLILGKNCLYLIDNFFQRSDGEIVNVWQAPKDERDQYLQMISGREAEDRKPVSVNSDHETRHWPFEDMISISKRRFLFRDVALELFFSDGRSYLLTTMSAKDRDSLHSKLLSKASNVNNSPASLHVGDAWRVEALKTQDNATNFGSKLVNVFTSNIPNPATKKWIKGEISNFHYLMLVNTMAGRTFNDLTQYPVFPWVLADYTSEELDLTNPRTFRDFSKPMGAQTQDRQHEFRERYRSFEEIGDRQAPPFHYGTHFSSAMIVCSYLIRLQPFVQSYLLLQGGSFDHADRLFYSIEKAWASASRDNMTDVRELIPEFFFLPEFLVNSNAYNFGMKQGTDEAIDSVKLPPWAKGDPKIFIAKHREALESPYVSQHLHEWVDLVFGFKQRGEAAVEATNVFHHLSYHGAIDLDSIQDPVVRLATIGIIHNFGQTPHQVFTRAHPVREEITHKSARLDVGAESLIRLPFPLLDNGERVSSLVYSTKYERVFCSSSFRLNLPPAYDKYMEWGFTDGSVRFYHFDSKKLCGHHEHLHQGQVSSAIFADPRTLITAGTDGTISVWQVQATSRSVELQLKTSLFGHVKPVTIMAISRSFSTLVSASSDNTILVWDLNRQRFIRQLQSDAAVQCVSVNDVTGDIAVCKGNRVTMYTLNGEHVLTQNICDLPEDNVLCCAFYEGLGNEWLERELFFTGHRRGVVNVWSKAIVDGKFKLLSVNTLQHASQFQTEIQASAAISAIHPMPQAVYTGDENGKVHEWDCQLVQRNQSPVLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFH1</accession>
    <name>A0A2T6ZFH1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000311">
        <property type="protein sequence ID" value="PUU74248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFH1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFH1"/>
    <dbReference type="OrthoDB" id="5396078at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="204" mass="22703" checksum="6BD7E108A6B8B240" modified="2018-07-18" version="1">MCMIKVRPEIEEEEVTLPARRVDRRRTGSRDSRIHETTVVETVKAPPPPPSALSLNSNHRGETTTIIQAPEPPPSSMIGSAAGGEMVRHHQYPYDSPRASVVSTRSRDYYVDSSAYAGRSPRSSYRYVDARGSGRVDGVGAGGSGKKELDYMRGDRYGYNNFHGRRSGSVSYVNPRHSTASHRSARSMREKVVVVDENGRQKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFV9</accession>
    <name>A0A2T6ZFV9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fip1 motif-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1000836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000305">
        <property type="protein sequence ID" value="PUU74359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFV9"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="347" mass="36412" checksum="4FF6C63AEA4572BD" modified="2018-07-18" version="1">MDQDEDAYLYGDDPVATEETSTSSVTLQQASNSPPRAVPESFPEHSGGDTPMADSAPEPATREDDLEEGEEEEEEIEEEVEVDDSEDEIEFVIERKDGTRPEPPPQPSRYNQVRMAPTRPVPESSSSAKATTPQASTNTTPHPPTGPASSQHPHPPTSSSSKLDLNGNPAYHGTPIKSISLDSDTLLPSDKPWRKPGADVTDYFNYGFDEFTWTAYCQKQESMREEFDPRKMMEQMMLLSGMTGGLGMPGIVVDPSAVNVGVGGMDMNAAAAMMGFNPAGGGGGSAGGGAPTTATGTSAGGTDLNMVSGMVDPSMYGAGPMGGGYDDRSGAAAGAYGMPADPRRAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG57</accession>
    <name>A0A2T6ZG57_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1033162</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000297">
        <property type="protein sequence ID" value="PUU74473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG57"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG57"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="921"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="931"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111931" checksum="B6965CA51D63ADA0" modified="2018-07-18" version="1">MEQEILRLLGETLSSQEGPRRNAEAQITNLYGNDALPLALIQIASTVHLNITVRQSALLVLKRYVQHCWSDGFEEFTGPLASDGIKDRLRDPLLSLVTDEQRKIRFAASSIVSKIAGADFPERWPTLLQGLLNVINTKTSAEYQVHGALRVLADLVDDGFSDEQFFAAAVQIVAVAYGVADSEDRDYTIRALSVLIFYSCMETLEMVKDDHSVEVNAFAMDRLNEWFPFFIRVMSKPLPDSTDPTYEGCVTLNIQVIRTVMQVRKVFPSLFAPYLREVFRVTWSGLNMIKDRYVHDFITKDSQGKLINSDGLPRTLDLLVLEQLDFIQTCLKSKPLRDELLQASRGAGVDAPLTQMVVATTALGQVAKEDEGLWEVDLNIFLCEESAISANYTPRTASGDLILKLGEWFQTETEEALWAHTEQIFDSGVGSRQMKEAALFAWDQLLTEFAEIGLKINSGTAAKLLNYVAAAISTEGEENQLLRARGYFLAGTLTKSNFETVGLQVAELIAQTLRGAANDPSSIVKISCIKVFQKYCEGAPPEVVKPCQPEIISAIRSFLATKEKDDAEDSQDVLGELLETMRGAVGLDYSAVLNPNLQIIDLVFAIAQNGPRSPHLGSLIHEIIADVTEELFSSFVQLCSQILPFISTSLAVQPDGKEHPLMNLAADILAVLVHNGSEPLPNGFVVATVPHLARILLHSEDTEVLQAGCEAFKEIVKHDIKQFLEWHDGNGKSALEVSLIIIDRLLRPGIAEGSALEVGGLAAEIVEKAGDHLGPYLPELLGAVARRLATAETPSFIQSLILVFARLVLKQAKDVVEFLAGLSIGDSNGLQVVIKAWLANSSTFSGYEEIRQNIFALCQLYRLEDPRLSQIMVQGDLIVPESNRIMTRSKAKQTPDQYTSVPVPVKIIKLLILELGSGGGDPTTSFSGGTLDDEEASDDGEWEDESSALGMAGMTKDELLALGGSGRQSRQADDITYTYLTGFFHEVSSQNIGSFQNVFSALKPEEQKQLSQLSSSQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGC1</accession>
    <name>A0A2T6ZGC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1000009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000293">
        <property type="protein sequence ID" value="PUU74538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGC1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGC1"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="231" mass="25366" checksum="B77561B0F3605448" modified="2018-07-18" version="1">MCGEVAGVFDLRKGREGEREERSRREVVCIGGGAGAEVVAAAAAVRSFLGRNGEESGEGGEEGAESERGLHVTAIDIADWTSIIDTLRAGLASSFISPSTYSVTFHHHDILSTPSPPSTILPPNTSLITLLFTTNELYTQSRGDTTRFLLSLSALTRVGCLLLVLESAGSYSTVEINGKIFPMGMLLDHTLSGEWEIVFKDESRWHRLPEGLKYPIDLENMRYFVRVYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH25</accession>
    <name>A0A2T6ZH25_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1156836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000275">
        <property type="protein sequence ID" value="PUU74756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH25"/>
    <dbReference type="OrthoDB" id="5415994at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="827" mass="89657" checksum="8281B1A42F14062C" modified="2018-07-18" version="1">MSCLAGFFSCFRSRKGDRTRDSTGGKTLISPSAIPPHTSDASLPPPAGESSSHFPPLPQFPQQAHTVEKGIVYPPDAGGIPASVDYFSDENYAILMKKGEESSAAGTALYSENFVGSWPKFNTKIRETSESSVGSEERDISNDNTSLKPLPKIYTGAISPIRIPSPSLGGTAPVAPGDLEPGRSFLSSLFEEYKPSPAKYKRSLGKSGTYREATLSLFTERRDVSRGKQQGVTETMRSLKPRTLYDREASSGPENVRAYEQPSSSEQLPSGDLSEGATKLSASSDPYNEKKVEDSSGNTIGISFRAEENSGPRQKPHTVPNDDTGSPKSTIKFDSSINFSHLRALVEPSESNLASSESLLGHKLGSSSFRKENFYTPAEIGALEKSANLLSSVRDYIPSQPTDDSSIYSSEHISTPSFVRMDGFSRDFSGLAFPSEAPDPKTPDQAQNSYQASDNGLRKKISPGPIFYPPAGRTRPLDVGTIRSIYPDRFPHSLQKSRRVTDHEILEKHLDSNDKLGEGSKGIQVQPRRSSYGAVTTRAGGSSCRFADAWNQEQCNKPGVDPLRTASCPLNPEFSPGIEGPPAASSYKDNSRTVLAKNQLASTGRLRSSISLGDRLRGHGRWNKDVDPRRRASTNSLGNRATPDTENTDENSDTKSKILGGRLKMAKSLSRLKSKMHPLSGLKYEMNIKGPASTTIYHLSSEKPKGDFKDKDKGRLTSESDSGNEMEEGMKCSEGAGEVSEGILGRDTDNRPIELASDGSGNEVPIIEPNPESALTGYESCVMLPFSLTSFETLAETRSQEKLVKPFSSPGHSKSHKEDQLKGLPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHN8</accession>
    <name>A0A2T6ZHN8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1103154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000256">
        <property type="protein sequence ID" value="PUU75001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHN8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHN8"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="134"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU75001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="460" mass="50310" checksum="5927B38EA44932B3" modified="2018-07-18" version="1">MNSILDSILGSHSPKVLLLGSGFVAKPCLDVLSDSGVAVTVACRTLKAAEELAKGVKHASAISLDVNNTGALEAEVEKHDLVISLIPYACHAQVIKAAIKGRKNVVTTSYVSPAMMELDQDAKDAGITVMNEIGLDPGIDHLYAIKTIEEVHTKGGKILSFLSYCGGLPAPEASGNPLGYKFSWSSRGVLLALRNTAKYYKDGKVEEIDAAKLMEAAKPYIIYPGFAFVAYPNRDSTEYKERYAIPEAQTIIRGTLRYQGFPEFVRTLVDCGFLSDKPLGFLKPSDNPLPWKTALAKILGSSSEKEEDLIWAISSKSKFKNNEEKERIINGMRWLGMFSEAKIIPRDNPLDTLCATLEEKMQYGPGERDMVMLQHKFDIELADGSKETRTSTLIEYGEKVGYTSMARLVGIPCAVATKLVLNGTISDKGILAPVTEKLCKPLRKELKDAHGIECIEETVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ95</accession>
    <name>A0A2T6ZJ95_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1090052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ95"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="9205" checksum="ED96EE52C569A803" modified="2018-07-18" version="1">MLYLPLPTFLMCLRCPGGCFLQPHPPHITVPRDPSITPCVRGTVQDWCSLIMSHFSGTVPRRQCNVSRGDKWVCTSTVPVHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJN9</accession>
    <name>A0A2T6ZJN9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_323705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000218">
        <property type="protein sequence ID" value="PUU75707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJN9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJN9"/>
    <dbReference type="OrthoDB" id="5425782at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015575365" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="4">
        <location>
            <begin position="161"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="283" mass="29593" checksum="3D854D398EB60DF6" modified="2018-07-18" version="1">MAKLSTLLYISIFTFLLAGGSLAQEQALQRRQDDQTSDDAATVTVSSPGRTSTTLIQITSTSRQTTARASPSQPSLTTTRTTSAAVSRQSTQETATGSTTTRSSSSTTSQDDKPGDSTTGSNSDSTSDSDRTTSMTTLSPTTRRQVTTIFSTITSGGNTGQVSTILSTSTTVETPTVPASSGGQNQGQNSGNEGLNPVTRNTIIGAVLGVGGALLVGGLVIFAWRLRKRRINPVDEDDLMRRDGSPLAAGRDKRTASSEESPFKATLDQYHKPPGTVNASSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJQ5</accession>
    <name>A0A2T6ZJQ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1067216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000217">
        <property type="protein sequence ID" value="PUU75720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJQ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="198" mass="22037" checksum="F6135703D925C28D" modified="2018-07-18" version="1">MGIAWGKSVPEGERRDALEHGGCIPFKSSLVIHVSDIDQGQHSIPMSCLPKRQHYRIIVMISPFSNALSRRCVVRMMSHDKYSDNPHDLPSIQTAQTLQVNPYDSATAPDLRALPGKSIEYCTGSNRGGLYCTPAISCALQEGTELFPHRRETHNGDCSNKRKPKKDHLTLDELLGNPQDIIRFKASDTAELASWKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJW1</accession>
    <name>A0A2T6ZJW1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJW1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="11422" checksum="16B2C971DCB0EE93" modified="2018-07-18" version="1" fragment="single">MWGYYFLLPVIFPPIGRKLSLSQLDALPSCQLFTTSLPGACTLGLVAVIHTKGSLIPIKQGKGSAHGPTTRTMKNGCEWHLQIFLLFWGLLVVFPFLPAFSFGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKG8</accession>
    <name>A0A2T6ZKG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mak10 subunit, NatC N-terminal acetyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1089289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKG8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKG8"/>
    <dbReference type="OrthoDB" id="269405at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="68"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="346"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="762" mass="86962" checksum="A94B15C526311B0E" modified="2018-07-18" version="1">MGEAESNGVNHLAYPAEDFERFTIKEKRPNPIPAPASNPIIPAPQATMDSFRDVTAEFFEASAKLEIGQLIKDPYFTLLQAVGALEIMDPKMDSGMLQAEYESFDALQPRLPEEVVGIMDQLLCHEMAWHTGSALSQTLFTSLYIDRLLSSSPSTLAEATFQRPPGKKTDTPEAQLLENVLQPFCVGLIKCCSHVNHQILTEQIYEEEDFVTQVYGVNLFEGVKSEEIVALLDSSLSWLEGTGDLYSEEIHNAFKYRLLLRKSLVLVFSSETKEWSPETTEVWDTSLERVKKVEETYKVGRAVPAAFSISVQRKLASQVPPRAMVNYPFMDAISDLKKLCVEGKDILKILNFEGSTNLVNYFLSFMTRQPAPSPYIRSLLQSVFFGQVENPGKLSIKRLLYDDLKELCYPAAILLDPQNDLVEAPQDPRFKITKHMNWFIERAGKSFMELFRNICQNRSRLRRTLCHSILDWDSLQVEAEEVDSDLRQFTNEEAVMTPNGPSFAFPLSSWVYHYKLRQMEWIMLLGFELEVFQTHEFAGMYWYLQHYTRTRIGHIERMLQFANRPTSSPPLERRKEPRSNPEQVKTLSLLNFYLLEATGVQELAGAMISLFTALSRLNLLKKPPQSFSSDALRYEVRMKPFFTIGCPEVAPFEDFESLVGNPEIETSEFLEMASESATDARKNFDQLCRLDARTARVVLCEERYRTSMREMMRSCIGVGVATAVLSKALQEGKATPELLDVQIDRERYHPSFSAPKIVVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL15</accession>
    <name>A0A2T6ZL15_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1088858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL15"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="136" mass="15349" checksum="A763E85D01995A43" modified="2018-07-18" version="1">MILKQRWIITVLQSLTVTTAVLGYRMNSNVTTFPLRFRSIPADTTKAELSESLSVSPECVSLARIKWKGDSSTATVTFKKEKLAKSFLKNDVLIGGERLLVDDHFLSLTVLSSHDDDVVEYDLVNQECYRICLCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLI4</accession>
    <name>A0A2T6ZLI4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1129872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLI4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLI4"/>
    <dbReference type="OrthoDB" id="10057598at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14518">
        <property type="entry name" value="Haem_oxygenas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="163" mass="17542" checksum="A6E7301613744952" modified="2018-07-18" version="1">MTKAFKVYPSHRTGSAPPLDDPQRSKSPRASPGGPQRGSGGRGHQEEPGIDAPVPHAVHKYGHWRWQRETVRGSVTKSEYRSAGLESCCLAAVHFPVLGVPAGAIGFSMAYENLPLHMAITVQELPESKPDPYYFILHISIDNSHSGAVGIPATTEHTTPAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLN9</accession>
    <name>A0A2T6ZLN9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial 54S ribosomal protein YmL16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1115906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLN9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLN9"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="5">
        <location>
            <begin position="135"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="25328" checksum="59FAE216B297FA3A" modified="2018-07-18" version="1">MLLPLNRCLRHAPKKYVRKFSSTSRASSKIGQSPVVIPDTVILTKLPPPMSKNPRETPIGSLQVKGPLGKLSLRLPPFVTITETPIPSSTSRRATVTVENAKIRQQREMWGTSRANLQKLVLGVTEGHSAILRLVGVGYRAMTGSGGRVLQMRLGYSHTIEMSVPQGVKCSVPTPTRILLEGVDKTKVNQFAAGIRAWRIPEPYKGKVCALLGRWRERRRRRTLMMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM07</accession>
    <name>A0A2T6ZM07_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1129706</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="NESQ01000187">
        <property type="protein sequence ID" value="PUU76486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM07"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM07"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="102"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="302"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="508"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU76486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="700" mass="76242" checksum="4DA278EFE24513A6" modified="2018-07-18" version="1">MLRSATRAPLRVLCRRFPSKNFSTTPTAEAISPHLRNQAVPARKNALSVPRNQSTSASIKPIPSSTPSQDPPSTASPAAHALHSLQPKYGYGEEMDDSFVGMSGGQIFHEMMLRHGVKHIFGYPGGAILPVFDAIYRSKHFQFILPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVVTPLQDALSDGTPLVVFCGQVPTSAIGTDAFQEADVIGISRACTKWNVMIKDVAELPRRINEAFEIATSGRPGPVLVDLPKDVTAGILRKAIPVASDLPSHPSAASLAAKQARKKHLDATIGRVAKLVNMARKPVIYAGQGVIERPEGPKLLKEFADKANIPVTTTLHGLGGFDELDEKSLHMLGMHGSPYANLSMQEADLIIALGARFDDRVTGNIAKFAPKARLACAEGRGGIVHFEIMPKNINKVVQATEAVEGDVAENLALLIPQVNSVAERPEWFAQINDWKKRYPFDFERETPGSMIKPQTVIEEISKQTAHMKEQVVISTGVGQHQMWTAQHFRWRHPRTMITSGGLGTMGYGLPAAIGAKVARPEAIVIDIDGDASFNMTLTELSTAVQFNIGVKVVVLNNEEQGMVTQWQSLFYEDRFSWTHQQNPDFVKIGEAMGLKSMRCSDPADVPGKIKELLEYDGPILLEVIVDKKVPVLPMVPAGKALHEFLAYDPDKEKQRRAALQARFPDGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM66</accession>
    <name>A0A2T6ZM66_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1088017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000183">
        <property type="protein sequence ID" value="PUU76573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM66"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM66"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="120"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="419"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="511" mass="55130" checksum="890932773EBB1519" modified="2018-07-18" version="1">MNNAQFRKLLETPRPANTSSQNGPPATPALGSKLRSSIPMTPRSVLGGSSTQSEFARQLAANNAAEQKAKKFRSSAAPLGTRLPEGYVDRTKDREDEGSDERARRLAALEELLKEGGIEHEDYVRQTKLLGGDVSSTHLVKGLDFKLLEKVRRGEDVMRAIRDDGGDEEEEGQNSEDEEDVLDKVLERDIVPEKKEEKKKKGNLAPKTRAEILAELKRSREAAKPVSVLGSKFKKIGVKEEKDENGAKVKYVTGADGKAKKMVKRDKKKSDEPKLVSTTIMGMMPPPPMPGQTEKKVEEEDEDIDIFEGAGIEYNPLAGLDGDDDSSSSSEEEGEEGEIQPTKKTKSEKALEPSSKPSPPPTSPSSSSMPPPPPSAPKPKVNYFNEQASSSSDTYKPPSSASALLSSNPELAAALAKASTLKAFSTPSEDEAGKRRKALMESADRDAVDIDFGFGGSRDFGDEDDDDGTVVKSSGGGKKRKRGGKPKKGDKNDAGVVGKIVEERYGGGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMM0</accession>
    <name>A0A2T6ZMM0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fungal-specific transcription factor domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1129273</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZMM0"/>
    <dbReference type="OrthoDB" id="2354469at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47783">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="867"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1135"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="928"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1301" mass="140931" checksum="3107ECD6B31F87DD" modified="2018-07-18" version="1">MAREPPLPIPTSVSASTSSPASNIKIERVLNSSSASTKPFLQAASVQNLLHPSNPASTPATTTTTAAAPRHLPTSFSASAGANTAATPAIASVQSLLHPDSASSPIQHHQHQHLHQQQLQSQRQLKQGHQEQLAPQQQLQPQPQLSQQLRLSDNSPSSSESSMATAVVPPQPAHVMQPFTRPIRFVANDGQPHAKRRRISAACKTCRKRKTRCSGEKPICETCRQNGHSCLGYSDPTNSMPVPSAHQTQRQQSRARSESTPTVTTTPTDNPPKEPLFSPTHSPHDRPKRPSVQQPLPSEQHELRGTESGTKSQKRKSTDCHDAIGRGYEYDMDGSGRADGGNEGELTDEGPSPIFRYPSPPSQRLAHRMPYFRYFGPTAIVPGYKQMVVEVHDRNNIPRHSSLSISANSSVTSPASTFGSLGNPNSTPTISSGTNSVPMEDIPFYDPSDPAPNSPLIAHLVETFFSHLGCNFPFLRREVFTKDVEEKRVEGILVDAVCAVAARFSNNSLLQSLARNGEKVPPSEYGTAFAIRAKSQVVDAFACPNLASVQACILLAYVEFGSNRDSGLWMFLGIAIRMAQDLGLQKLEGTRGDAEAGIKVRRVGGSRSRSAEQSPRAGTSAGNGHRVKLESMGRYDDRVPENHENYVDDESVREAKARERERTDTFWAVFFLDRVISSGTGRPVTIRDKEIEVDFPPIEEVDLEHGYPPPFPALIRIIQLYGRITDLLNSIKDVHTVTPDTLRSLSGMEADLTKIYQRLSPKLHFGVANFQHYASTNQGAVFLLLHFWFHTLIVLLHRPTLLIAFEGSIQQLFPNSRELSMSSAKTIADILAFAELLDSKAVNGNPFTSQPIYIAACAFLQESAAHSSSNPTSRSSSPPPSGSLPSFNALTLGSMAPESNSTTSRPPTAGRGSPVSSNGTTVSPGNNGITGGGTTGTSGRGMISGFGSKIMEEGTLVQKLSAKHTLLAQAAHQNYQKCYKALKAMETYWEGVRYILTVMDQKAKGIVDPLLYTVEEMESVEVHRWGAGVWNRFRGDLTPGAERVNGAVREKVVKLEGGLPQSSLMPPGGQSGLGVNRIPERIPSPLMSGIHGNPSQAIGWSLTGTINSPNSNLAFMFPASGEAGVYTIQHQQYNGNTSSPHANHHGGIQQAQDPRNRHMASGMHPPLPHGFVGATPASAASLAASSQSKYSVGASTPAASDAEMLLGLSVEQQRQQQKATNVHHSPMDGLIMGEGYNNDEVGSAMGAYNAYNIMIESEDINMNSMGVNHLLPFLEFVPYDSYQYGTESEDGLVNDHHHHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMS3</accession>
    <name>A0A2T6ZMS3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1148279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000175">
        <property type="protein sequence ID" value="PUU76791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMS3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMS3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="24684" checksum="ED147F9744D8F516" modified="2018-07-18" version="1">MVFLGPFILTRNPKMQKPPLLEKPPRIPRCRHFRTPLPAKTRQKGPRPSSLRSSSLANAQGQQGPLFVGADRWDLDQGQLMMEDGMFGGQTGGTGSSREDPMLQMMQQLKGGAGGLGRMGGGNGGMGGLGGLSGPGMRMGIPPSETQQMQQKEQSCGVVEGITLLSSLCLAGWVRQGTGWSCTRSALERAESANMTRKEARPLFWHSPIMELILQSPRFFLENVGEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN57</accession>
    <name>A0A2T6ZN57_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1128972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000169">
        <property type="protein sequence ID" value="PUU76913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN57"/>
    <dbReference type="OrthoDB" id="5408795at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="3">
        <location>
            <begin position="359"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="675" mass="74235" checksum="2B5ACDE4F139AEA9" modified="2018-07-18" version="1">MVFSKTGSGANAAEGSKLDMREMFKLITEKLDHIQGTQHSILASFTEQSLAQNREIEELRRLMRDTEDRLKAQELSELRKALAHTEVTPSAGRRFSSEAFEAPTSASRDKTSSIQPAEKPKHNGTIADSFERTMSPDYDMPPPAADQDIEMTMPDASDSDRENVAPAPPAPLPRTESPVLEAPVFLSATESNKSKERPIQKMRPTRGRPGRGRGGGRASIREGGDLSSNSDESSSEKAVEAPKMVPTRGGFGKARRAGPLMGGRVQPQAKSPPAVDPIEEESGSESEAEEQVPSSGFVAVNQKTARTPAKKAAPLLASIGPGMPSIPTSTPGKKIPPPSAKVLARDRKLPKTLPDKPFWFTADAIKAITGTRPGKTVAQVTKENVLHYEYYIVFTPDLHFSPPKAIGDTCELIDLHNAEGELLASRYPIFKKMDKAHFAFYGEYKVGGRRVVPLSVWQNSDPVVKKKWAEKFINTGWGSKMLLDKGLRTPGEIRNFTLKDIMEFFNRDDESRALRLSATSFEFVDFDRKLYDKMVVVAESLSNGGIPAPNVTPSSLTTRVPKESTIVNAVDVEDNDESPPITARKRRKVGTESPVQVAAPDRERRFPERARRATQGAQYSIVHLSKAGEHESTPSSSNQWRVESRKKHEPMPVETSADEDDGDENEVEIQEVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNE1</accession>
    <name>A0A2T6ZNE1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1087126</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU76976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNE1"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.240:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim44-like" evidence="14">
        <location>
            <begin position="365"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU76976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="525" mass="58429" checksum="ED2780A5DB5D08A8" modified="2018-07-18" version="1">MHPLKRASFAAAVVASRYSTSAFRIGGNQRVHWDLLRLPRKSHCGSGGTMPGGGARFGVLRSEFSTLRPLYEKVKTPGAEAGKEASDDNSNSGEGGKASSSSGTEEDKKKQKEEGQEEEGQKKKEEAPPPPPPPHGDKSPLTVFYETLRSEFRKSQEWQESTKQLASSAQQFTESPAVKKAREAYGTTTQVAEKVGGKAAETLGKTASAVGKGAVWTWETPVVKVGRAAVRKTGEGVATITKPVRETKVYKDVVGNVKEVIDDGSSSRYGGYLEREERKRQRVLRESKGGVKTEKHEENPNAGTNVTLHKDAAWKESWRTFRDSNKLMQSLFTMRKSYEESDNPVISVTRSIADRFAGFFAENETALVIRKFREMDPNFQVEPFLRELREYILPEVLDAYCKGDTDVLKAWLSAAQYNVYAALNQQYTTNGLKLDGKVLDIRNVDILSARILEPGEIPVFIITCRTQEVHVYRDLKTGELKAGMEDKVQQVTYAIGITRLPDEVANPETNGWRLIELQKNARDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNF5</accession>
    <name>A0A2T6ZNF5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1087194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU77022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNF5"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="4"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="271" mass="28920" checksum="AD59E5AF4F1FDE19" modified="2018-07-18" version="1">MNPHENLSLAEAILGAIFLSLTIFNISRIPRETAWWYITVFCLFRTTGSSILLAVSLKHDYTNKGLLIPAIIFSGIAISPLLAASLGFLNSCTKHLPETRHPILRLLGIAHIAVIAALVLNIAGGTTMPYGAQSSSTSVVNSLNSAITYLRASAMVSLVAWGLILVSLVILSRHWGAFGRAARAFYIAVAGAVPFLFIRILYAILAAWAWKKGVVTAVPGGGKYGLITGDVGVLVGMRVLMEFLVVGGWVATGIWVGQRAEEFDAKGEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNQ0</accession>
    <name>A0A2T6ZNQ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNQ0"/>
    <dbReference type="OrthoDB" id="5320605at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015524375" evidence="1">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="193" mass="21878" checksum="83C105E7DE82B27F" modified="2018-07-18" version="1">MCIRHTITLICGHVFATTTSSSDSCPTPEQAIAILPAKLVETSCFAYVQKAQKSRLEWVGERLEVTLGEVSRLLGRAQRDSGYIKREVESIRAWVDLLERRRNNRDGGIYDELKYVIRSSREYAGDLESGKFTESFEFWCKMKNESGLEGYHVQEGGRGYGKMYNEAWERLLALKKPGDGFSEELPPVVGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNR4</accession>
    <name>A0A2T6ZNR4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_987973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000162">
        <property type="protein sequence ID" value="PUU77128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNR4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNR4"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="79154" checksum="00BC080B53C48205" modified="2018-07-18" version="1">MPTTRGSRAAKPVRYSADPYQDLDSDAEPRPTNNHHEEDEDDEYQVLESPGSSRRRSPPKISGQDASASDANSDSSEDEEEDDEDVYDSEEETPRTRGNLRGRGRGRGGISEQISGRCRDTTALISSTGARVHRRHEFRTPRTSRKRRRRAASVDTNSDAEEGGSLTLKLPNPNVKLTYRPRVNQATGKRERLFTTYGMNTHALVIATGVRDRSLGVPAVPEEGSFEPNPFWQEGQDKLVDLGDGMQRVERMEYYDVNPVDGTGYTAETYMPSKKEEPIKCIIGPGAEQKMLTFQRFGVFNLKESGEHKKGYILNAGGRVVSMEWAPNRPKGVQYLAISTKKSGPDRSQLPEPKPITKSIYAPESSPSCIQIWRFPTSEDVKPGDPPSMALALCHEWGYAQHLSWCPIKKTPKNEKELGLLGGVFRDGKLRIMRIILPDDDTDGDCIFLKAAEPAFECSIKDSMCSSLAWVSDHEVVAGTTTGEIAVWDLRYKFDGEFIPTQLFPLHHSYITQLATCYPSFPHHILTASMDGYCRLTSLLDPFADTIVNNRSRIAPQSIAWVDALQAAVSSEEGAWIKYYPLRRFYSSTMLARHGGVGGSVASSRMHTFVLSGGTEGEAIFSNPARRMFHAKIKNYQQTWFQLEFAQSTGMFRINEGFKLEMREPLSAMVHSTQSAIASVCWNPNDNCGGWATAGAACGLVRVEDVTIYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP05</accession>
    <name>A0A2T6ZP05_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1146547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000158">
        <property type="protein sequence ID" value="PUU77220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP05"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP05"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="769"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="772"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="820"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115379" checksum="FA46ACC0AC0986A3" modified="2018-07-18" version="1">MGISSEAFERLQSQPGKYFSDNTNSFNTNIINNYGIQVPSRVPGMQLFISSLSFKLMAKLRVESFEELIRDTRWWVSPPEIDLDHLRDKHNLPEAGTGKWIFEDVGFMEWRESSESKLLWLCGGPGTGKTMLAKHVAAEFPKECDSPGRGIKLAFHFVSPKLSTEKISADQAELLQPSLAKVASDLLYCLLRQDGNLFDGCKAQLAMQGARFFTNPCSLWKVLGKAVQDCQTDDVYIFMDGIDGLEESLCKELIERIRGLAETSKVKIFLSSRVVPHVSNNLPGHMKIDLDGKDFVKRDVETFIRHRVNALGDWDDNLKERVREAILAKSEGTFLWAALAIENLACFSSGLDFEAVLEELPLKLEGVYQKMLRTLSQRKRSENVLSVIQIVALALRPLKVCELRSILARMGGGVKAEGLSSHREPGSNIDEIGMYVQSALGFLRAKDETVSIVHHTAVEYLFDEKRKDNLPVLSKSEVHFTIAWECFRYIHLAFPYPRYRQAGAGWPFVKYAAESWFIHARRSIEISIGSFRKDGAHMWLEYQFFKTSDIRKAWIGLCGDPKMEVLAGEQTPLHIAVCLGLTPLVEKALTDPTEGAESSNQLLHLAAEFMSPASGILIDKGWPSMLTAQDKAGNRPLHKAVIFGHWPMLEGLVERFTTREQGTHNNEINGRNHFGNTPLHLAVQFDHPDIVKLLVENGADTTIKNNAQKTASQLGTEMGRVDCLDSLEAGKEDAAERARERAAGERAVEEQAAGERAREYVGELSGRCAGKRAGERAGRRVEERAGELAGGHAGERARELAEGRAGERAAERAAAEHAAKRAAKREAKRKAKREAKRKAKREAKRAAKREEKRAAKYCGGDYGGAMGGAGEGPGRSMIENKVKEIRAETGDIGAREREATAEPLVAEEAIHETVEGLGRSMAEKKVKGVRAETGDIGARERETTAKPLVAEEAIHETAEGPWRSMAEKVKGIRAKTGDIDAREREATPEPLVAEETIHGAAGGPGRSMVEREVEGIGPVTGNIGTRERRATTEPSLATDLLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP68</accession>
    <name>A0A2T6ZP68_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1194165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP68"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP68"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043436">
        <property type="term" value="P:oxoacid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="54"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="20426" checksum="9BE8678FFD2BCDD4" modified="2018-07-18" version="1">MLRKIVFTPRAWELLAIFTISAAGPWIAAADTSQAWRAEMAEMQKRFDREIDVLQHGTPAAQGVEFYIATTSTLEVESATKAGNLDALINAGRMGLPAGYGPLIALEISLLKDGEVRISATSSNFKGRMGSREVLAYLTFPEVVAGSEMRGFVASPGTYTASSSAISISSLPSPAPSLTQSSNAKKVETEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP94</accession>
    <name>A0A2T6ZP94_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1027392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP94"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="54" mass="5699" checksum="3594C1F0C6E4B4F9" modified="2018-07-18" version="1" fragment="single">VSLADRGGKQGLCKLVRLPHGTKECIDSEGNGQRGSVTIDPATGRVDYAESSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPF2</accession>
    <name>A0A2T6ZPF2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1050505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPF2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPF2"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="51"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU77370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="363" mass="40079" checksum="0F25011D839ABA02" modified="2018-07-18" version="1">MPKAKKQLRPVGNSPYSRPNAAAREAASKAVNNVFRMNTDLGQHILKNPGVAQAIVDKAGLKQSDVVLEVGPGTGNLTVKILEKARKVIAVEMDPRMAAELTKRVQGKPEQNRLEILLGDVIKTELPYFDVCISNTPYQISSPLVFKLLALSPAPRTCVLMFQQEFAMRVVASPGDALYCRLSVNAQMWAKCTHIMKVGKNNFKPPPQVESSVIRIEPKNPRPPISYDEWDGLLRIVFVRKNRTISAGFKSSAVMALVERNYRTWCATNNVKLEGDDGEADMVGAGEGEDEEMEVDEDGMGGVKKVKIKTGKHSRSRVREKVKGLVETVLAETALGEKRAGKCDEADFLKLLYAFNQQGIHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQD2</accession>
    <name>A0A2T6ZQD2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1145019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQD2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQD2"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="378" mass="40974" checksum="5835580542C8400F" modified="2018-07-18" version="1">MSLPLSEHLVIEFAGLAPGSPYTGHLLQTYGARVLRIDPHTTPPTPTADTLTEHKRSLKLNLKSTAGHALLLRLLPKATILIDPYRPGVLEKLNLSPATVHAINPKLVYARLTGFRRDGKYAGMAGHDINYLAVSGALSLFGKKGEAPTAPGNVLADFAGGGLVCFCGILLALLDDGREERIVEANMVDGTAGLTSFARFEMAKGAAGAWGNERGGNLLDGGAPFYDTFQTKDGKYMAVGALEQGFYEAFVEGLFAGTGLHGKVPDRIRGNWPVLRERFKERFLQKTRKEWEGIFDGTDACVTPVLEHGDLMARGFEQRPIVTLKGVEVGGSGWTGKMLKPGEGGREALSEWWGLKEGVEWRVSEEGVFEDVRKKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQD6</accession>
    <name>A0A2T6ZQD6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1085744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000145">
        <property type="protein sequence ID" value="PUU77676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQD6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11056" checksum="5E85C50DA1C5D91F" modified="2018-07-18" version="1">MGLYLSGVGFGLRFLWLCVGVFCRGVMAVLRGQLKVLSCNYGHLELMGFCIRGRLALAALVFFSFHFLVSLDLGGEQGREWGERVLLDISLLGALRCEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQR7</accession>
    <name>A0A2T6ZQR7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1049650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000139">
        <property type="protein sequence ID" value="PUU77817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQR7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQR7"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF123">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="40796" checksum="ED6CE91B415281A7" modified="2018-07-18" version="1">MGSTLGPLFLGVMYALLGLSTLFVVLRFYCRLYIVKMIRSDDWIMLVALVSAWGLGVTNNFHIKYGIGKHTVDNAKDYKKIIVPILTLWYVYQLQYLITLFLIKASILSFYRRISRERSYQISVWIVGGIIVAYTVAMLIVNLFECPRDITRAWSPGFPTGCNDLSIVYYAMASFNIISDIVILFLPFPMLLRLQTKKRNRVALLLIFSCGSIAVIASIVRINALYQNKKALDRGGDTSYLATYVLLWSQIEVNVAIITACAPAMKPFVSSVLQSARSTKPSYAQDGLGYTGSAAQGGGRVMPLRSLGIRETRGPVGNTTTIGGGLNESQEDMVFKGDGIVRTVEVKVDMEVDGRSEDSIRQLEFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR58</accession>
    <name>A0A2T6ZR58_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR58"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR58"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="182" mass="19580" checksum="2A8698B0A0916501" modified="2018-07-18" version="1">MLAGHEWSLFGHHHRTLRVTSPRPGQHSTYWLQIPYTYAIPLMTFSGLLSWLTSQSIFLARIEISDPLGKPTGTMTNAVGYSCIAIIFVLVLGILALMAAAGMGCRPFAAEITAVGSCSAAISAACHAWGEDSEGIVGKKVRWGDVEIVPKSRVRHLALSSREEVRKPIFGVAYAGIGREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR91</accession>
    <name>A0A2T6ZR91_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1127463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR91"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR91"/>
    <dbReference type="OrthoDB" id="5429634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="366" mass="41538" checksum="BFC4A37483D4EC76" modified="2018-07-18" version="1">MEGFIGTAITEERKAKAHRMSKIGSSEFEIVDPDLIDPDLITSDELTRDDWDDLATILQNLKPFRRLTLQLQGSGTQANHANPVWYTSWHTGILVCATSVIVVLLINVGLTVYATTNPGYEMERGIGTFVRNLFRIKPERALLWIAIGFTSIPLHFLYNSVVYNSLSANDFLVTVVTKDHFEPGAFSNLSMVSWFLPSLNATTGEGYRYLDDMELFKSMLEGHNASTHRYEDLTPSEAQEVEISGCKSERAAEKCKVQFSLGIMIAIICCNLVKACSMIMAVVRSREPTLVTLGDAVDSFLRAPDPTTMGICYADRRFIEEEWRRGWKTGPRYWKQKGVQRWWTSVSNVVYRETALYRDPARPWHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRA4</accession>
    <name>A0A2T6ZRA4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1084988</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000131">
        <property type="protein sequence ID" value="PUU78018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRA4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRA4"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="300"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="380"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="140"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU78018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="510" mass="55224" checksum="7E0046F74171734F" modified="2018-07-18" version="1">MAFSRSARIITLLVIDSLFFLLEIIVGYSVHSLALVADSFHMLNDVFSLLVALWAIKLAKQKSTSSYTYGWQRAEVLGALINGVFLLALCLSIFLEAIQRFFEPREVSSPWLVFGVGSAGLASNILGLFLFHDHSHSHGGNSHEHDLESSLDGERAAAGHEHHKHTHGLRGHIHDPAEDDSGDIDDILPDTVVARLSQPIPSSSAPRRKERRSADRSRQRRFASPVTDIHVHPARNRQEVIAAAVSDTEHSSSAVISSADSDSDAPTSRTPLLSAAGKGHKRAYSRSCHKNHNHAKPKENKSSHSHQNLNMRGVFLHVLGDALGNVGVMSVAGALILLPETIWWRHLLDPSISLLITIIIFSSALPLCKSASKILLQGVPKGISLDEVKEDIASIQGVESVHELHIWQLSDVKMIASLHIQISFDPECEGGGRYMQLASAVRTCLHAYGIHSSTIQPEYTKEEEAVASRTGSTRGNPEEEAACLLECGDGCVDGKCCVPGSGAPGDEATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRD8</accession>
    <name>A0A2T6ZRD8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1108517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRD8"/>
    <dbReference type="OrthoDB" id="5403934at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="19141" checksum="7F8E29D37F3C3F89" modified="2018-07-18" version="1">MMTTTPHPPTNLHESTPLTPSSAEPFLSAFLADAGQKPNQNEIVLTNLLRVQRALAGVYVPPSPPPSAAMVAAEAGILTKGEARVGEVAGEGAGGGEYGEERVDSDKEKGGDEIVPGIATAEVGGMDRESRKERKARKRRREEKAKEKERKRARKEKGEEERKRARKEKGEKGDGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS38</accession>
    <name>A0A2T6ZS38_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_983807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000124">
        <property type="protein sequence ID" value="PUU78301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS38"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS38"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="13630" checksum="DCF7EB48DAB6CB2E" modified="2018-07-18" version="1">MVAQILTQIRSAFKTRRCESLTFTELDPSVSAEILKNILGQKDIWVIIHFIAPDRYLRIVMASGLHETGVDWMRTQYTLWISSGLLTLSAILSISDALSGKSLSSVISNSQVYTNSFHRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS97</accession>
    <name>A0A2T6ZS97_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_983450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS97"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS97"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF29">
        <property type="entry name" value="PUMMELIG, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="135"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="520" mass="57903" checksum="A9A9290F28E9B804" modified="2018-07-18" version="1">MAPSPPNEELQSSTQQSPLASQRAPETQGTASETKTTRFPSNLFPLGYKEGFSQWWTAVSPTVAESTVLGYLPFNKKPAPATSPQEGHAEATTNPPSADQHGPRECASNLVPLSGKNRLINEFSITRTAEGTPENHLVMLHGYGAGLGFFYKNYDQLSRRPGWKLWSLDLLGYGRSSRPPFTIKSKDSEGKITEAEDWFIDALEEWREVRGIERFTLMGHSFGGYLAVRYALKYQNRVNKLILASPVGVPEDPYAVREDLPDEGAKGDKSALDQEFMQTQREATRSNPNLPDSLKVPKDSYPSPSAPASASASTTSLGGKTLNAPAPRRPLPKWLVCLWEANISPFSLVRWSGPLGPRLVSGWTSRRFNQLPPEESRALHDYAYSLFRQRGSGEYALAYILAPGAYARRPLLWRVQDLTKVNRFGIPSVWMYGEMDWMDIAGGYAAQEKIQNTPVEEGPSWIGGEEWRSGKKGKGGEAKVLVVRNAGHHLYLDGWKEFNGMVLKEMEDVEKRENLRKQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSP5</accession>
    <name>A0A2T6ZSP5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_65899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSP5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="14560" checksum="743DCE7B86D6E328" modified="2018-07-18" version="1">MLYQTTHSLNCFLFFFFFFFFSIMIMIILRKIHLSTRIYLSIYHIYDNLLPSFLLQISMYISMYSGMDVGDRTTYPSIYVSMYECMNKNPPLISHKNKKRETRGDFFFWNFRSSAIKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSS9</accession>
    <name>A0A2T6ZSS9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1193257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSS9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015626325" evidence="2">
        <location>
            <begin position="19"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="283" mass="32286" checksum="D2A8771DEED12072" modified="2018-07-18" version="1">MLTPPHILLLLFPYLTLAHPTPTPLPCTHGTETQISTSASTPHRRSTYTPPVPNPTFCHTCVQNSETPDQIIIIWDEDAEPSSPPPASDPTQTLQKRGNLPTKFAKWKKNMGKWKCKGKKGEKKWEGECCKMKGECCKMKGKAEGKKQKKEKEKKEKEKKEKKKKEKKKQKQKKPKFKNPPTGYIPVHGSDSDDIQLKEPWLELRLDKRGMGDELKEEVGEMEAVEVEQAEQVEEVEQVEEVEGVEGVEEEVEEEVEEEVVAEAQTKMFSTILEAIRRFLHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSY8</accession>
    <name>A0A2T6ZSY8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1083715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSY8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11523" checksum="D4C8C41B6C3215BE" modified="2018-07-18" version="1">MFHLEPPPSLCFLLTCILLPRRCYEILITPRQAERGQATGNAQEEGKAIIRRYQNFRRTFFGSVQYVKLVSEEPVSRYITLQWYCTCTSAPPACAHRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT56</accession>
    <name>A0A2T6ZT56_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000111">
        <property type="protein sequence ID" value="PUU78656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT56"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="89" mass="10289" checksum="7B664ECAEC84634D" modified="2018-07-18" version="1">MVWQEVMEQLFKDNQPNISLSVPVKSSYTRVNNHYCIFSQTSQQEVSQAVKLFTDNQYTDGILIVTEGRTRVEVYGYLGPYHKPVVTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVJ1</accession>
    <name>A0A2T6ZVJ1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1081755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVJ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVJ1"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="167" mass="18085" checksum="C23C4F755F0FEAA2" modified="2018-07-18" version="1">MSVTLHTEAGPLKIEIFCEAVPKTAENFLALCASGYFDDCPFHRNIAGFITQTGDGELGNGKGGKSIWGGKFEDEIRPALRHNVRGVVSMANSGPNTNASQFFITYGAHPHLDGLNTVFGKVIDGVDSTLDKLEVVEVDKKYRPKKPIKIQRVTIHANPLADMDGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVV1</accession>
    <name>A0A2T6ZVV1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000086">
        <property type="protein sequence ID" value="PUU79620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVV1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="12899" checksum="45CC2B9EF9B903CE" modified="2018-07-18" version="1">MEHTAKKTQNVPTSAPDETASRITVSEPTLPRRAGLRKTVPTIQSTKPNTRSTRNGRHQNAPTVNSMRSPRTTQNPNIRQNPNSRQTHIASRNANLNARRNANVGSGGGRSQGLNANLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVZ8</accession>
    <name>A0A2T6ZVZ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetochore protein Mis14 like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1046377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVZ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVZ8"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25165" checksum="89525C167A3F283C" modified="2018-07-18" version="1">MEPNRMRKIEVQSPEDIRFILENLSSAARAKIDHHLPPTTTTTTSDNNDELRKHVEDMVMEYVQKTITLSLPSISINGLDAPIDVRPFLHPSSSSSFSQTAGGGEGEFEAYDRKLHDRVSALYAELERETLRVAQLRREAPGRAKRAFEEALRREVEGDERILRELERKRGVSSREEGEGEGGGGQAGDLGVRELERGEEIARGYEEGVGILMGLQSVSILLVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW07</accession>
    <name>A0A2T6ZW07_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAR2 protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_895913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW07"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW07"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="3">
        <location>
            <begin position="170"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="390" mass="43713" checksum="D85D5C902B9CFA85" modified="2018-07-18" version="1" fragment="single">SLHLTSIPPGTFIGIDLTTFTSTPAFQGIKLIPPGLHLLYYSTTTDSSLRNGFWFYAHPERVISKAWDPTADTATLVDAPSSAKLEERVYVENLTPYRQRARRGGEGEEEEEEEWRALSGGVRERTLERCLGEGWVCGTAGVSEMDYDVGEEALMGFPPGGGGGVDVVWTKVDLKVTWPAGTIGRERTEMANDRSWALNNLLHELASGNQEEEEAERELLGELQLSFIMSITLGSYSAMEQYRRILGLCLTSRTCVFHERRGLFEGLLETLLAQLDYVDGDFWAGFVDGGDGDENWLAKLLRRFGCGIKEVVSEQRQVDPDKDSIVRLFRGIESLTRRKFDWVLDRRDVVRRGLVQTEDGDMVELELAGLDEEDETGEYAPVIVEEVVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW39</accession>
    <name>A0A2T6ZW39_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1064038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW39"/>
    <dbReference type="OrthoDB" id="5423251at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14605" checksum="4C63D45196D3D3A3" modified="2018-07-18" version="1">MYNKFTSIDRFLAGSLRRMAGAWYGVAINQSMAVGNSVSKTHIDWQDCLSGFNAVIPWGTFGSGNLILWPAKVVYQVEPGECLFFRGGIMVHQVELVMSGIGNLLDLFCHKSAFDWHKRQLRASGIPDFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWX8</accession>
    <name>A0A2T6ZWX8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_977015</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWX8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWX8"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU79979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="334" mass="37941" checksum="61B159F3ABD65411" modified="2018-07-18" version="1" fragment="single">ELAAAEMEDYDALVHKLPALKLNYEIGSGFFGIVFLEKVQIREMESPALWAVKRIAKDVPYFPIRRYQEEVKNLQALSKVSFYEWFIQFYDTCEDLHCTYIAMEYIPIGDMLKTFVNGYRWNESDTKVVIKQLLQGLAVMHQEGITHRDLKPENIFLSLSMNETQSLHVKVGDFGTSKHIPLLNASTCLKTTTGTSSYMASEMLDRSKHKTNRVDIWSLGRILYRMSAGSPLFKDLFELYRYAATASAPPLALENRGLSPTCVKFLRDVLQPTSEDRPSAEACLENSWIVNDVPRSQYSIGKDLSTRLFKIKLGAPDIDSLSDVVTDLEPITLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXM8</accession>
    <name>A0A2T6ZXM8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1123951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000070">
        <property type="protein sequence ID" value="PUU80228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXM8"/>
    <dbReference type="OrthoDB" id="4638065at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="20128" checksum="6291A2568DF0B06F" modified="2018-07-18" version="1">MPKGVMRLQASTAIILTVKAISKDKTRSRSSTAEWPVYIYTRNTIEVFFQIDSHGERAPPTSGKATLEDTKALDSSFEQIDICDKGFYVALDKNYEKIVVMFGAGLRLIYGDKIGEYMEKVMSWKIEEYTSVNVPAILKDTRHKDYEKWLLSNPHLCWPPWAHVTHMRIARQYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXZ8</accession>
    <name>A0A2T6ZXZ8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase CBK1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1079582</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXZ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXZ8"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21773">
        <property type="entry name" value="MobB_CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000828">
        <property type="entry name" value="Serine/threonine-protein kinase CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000192">
        <property type="entry name" value="Serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050839">
        <property type="entry name" value="Rho-assoc_Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988:SF76">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_135, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22988">
        <property type="entry name" value="MYOTONIC DYSTROPHY S/T KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="225"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="534"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU80344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="615" mass="70188" checksum="09EF965B99BB793C" modified="2018-07-18" version="1">MSNNQDRDRGASPNSNYPTTPGTAYQQTYGGQPPQQGGYFPQQQQQQQQQFVNIPFNNPQYPPQQQQQQYQQFQAQQLYQQQQQGQGYDANGLAHQLQNQHLSARQGNQNNPPGSPQGQRPRTAGSLQASGSLKDDYVVFPRDDSTFSSSTRERAKALKVKVELHYNQSVAYAVERNQRRVELEQDIVGEGKMSEERKKRRRQQLGKQESSFLRLRRMRLHADDFVTVKVIGKGAFGEVRLVQKRDTGKIYAMKTLLKSEMFKKDQLAHVKAERDVLADSDSPWVVNLFYSFQDAVYLYLIMEFLPGGDLMTMLIKYEIFGEDVTRFYMAQCVLAIEAVHKLGFIHRDIKPDNILIDKDGHIKLSDFGLSTGFHKTHDQKYYQRLLEGSSNTPETSNNRARNSVMVDAIHLTVSNRNQINTWRKSRRLMAYSTVGTPDYIAPEIFLNKGYGQECDWWSLGTIMFECLVGWPPFCAEDAHETYRKIVNWQSQLYFPEEIILSPEAEDLIRGLITSSDKRLGKRGADEIKAHPFFNGVNWDSLRSIEAPFKPNLSSITDTSYFPTEELENVPTAPALAAVMAEGNSQQQLAIGEETGLPFIGYTYKRFEHLKKSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY52</accession>
    <name>A0A2T6ZY52_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1171888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY52"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY52"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="424" mass="47224" checksum="E0EDF3E4313E4E0F" modified="2018-07-18" version="1">MSYYLFKQRMGANIQCSKKNFFIAFHVTCGRRVRLSMRMKNSLGRGALMETSALKGYCHKHLPEQWRRDNNVDTAVTDAMDIYANTMTGMQCGDSQSAATPGLDHALLNGILRTNLPQITLTLGNKSKRSQDPKSTWKLAPGAPVIPRVTYDGVVKLIFQFDGSEVEEFVASARKYWTLKGESWLGASLVKSLQASINSFTSAEVVEKKYSSAGFKQGTIDLEKWKALAQGGVSELERLREIVEEKQEKESKSTEAMNFMEAYTDLTYFSELPLFRNVFEIARSFDPNHVSTNGLSLIEGSIEKRLYPNVGAFACDLLSVLKSPPSQAVLEYKVVYQYQLGSGLIRSSPKDDLHGATVAPLILPQVLPLLENGRRFELEIQTSPPPPEIPGGNIVDMKSIETYYNMNGEIPPSMEDNHALSPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY81</accession>
    <name>A0A2T6ZY81_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_974871</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY81"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="291" mass="32451" checksum="DC9F716F7422EE00" modified="2018-07-18" version="1">MAAAVKTSPPHSSASSASSASSPEPTTMAQQTQFPTPRRKGGRKPVYATQEERKMRNRAAQAAFRERRTEYIKHLEATIKHQEESLSSLQQSSRNAADEVLMLRYKNSLLERILLEKGINVAAELKAFAQYDDRPQPAAPQSISRPIPSQQQQATLQQQHMHRPMIAQPQQQQKRPSINPSPESLFIKTSPIMPPSSRNNSPSIAIPTPPDASAYQIPQSVVTTPTAPSEFQHPGIPMQNFYPSPYQAHMEELGKLPRSRNMTPNYSRVQKTTLKADSKINLQQQTGLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYW0</accession>
    <name>A0A2T6ZYW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_974010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYW0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYW0"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="338" mass="39294" checksum="2C08A9996F04DFE1" modified="2018-07-18" version="1">MSGQIFNREALSELPLDCTNIEVDSGMDYHESDEDQVPSGCVSVTSSVMDYQYEHGRRYHSYSQGNYPMPNDETEQDRLDMHHQIFLKILNGKLFLAPLDRDPPKRVLDVGTGTGIWALDMAEHFPGARVIGTDLSPIQPTMVLENCRFEVDDAELEWTWPQNHFDFIHSRLLVHSMKNWTRYLEQIYRHLKPGGYVELIEHLMDVRCDDGSYPERCAMRQYMRCLNRALEQMGVPCVASRLRGMAIDAGFVEVREEIRNMPWGPWPKDPRMKEIGYWALLNSEYSFEAYGLALFTRVLGMTGEEARELCTRAQRDLKNKHIHVYNPNYFVIARKPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYX1</accession>
    <name>A0A2T6ZYX1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_700747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYX1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="23226" checksum="8CDCA2421810FE3F" modified="2018-07-18" version="1">MASATPINPHKLPSPLRPGLTVSCMIKVPIPMHRLVPKASRILAFLRPNPCQGSVTFGTCLELNYNPLRLEFLGHCPATDRPRGAEQVCFSIRPDFHIQPLDPIRRRQGALDLVGLAYIYPITNRHLDSITLHSYTRAVCPKFQCLQEYRLFYKWPASPLKAFVRNLGGCFVTLAKKTCHNSQLLPPSPNPPHISTTFHGIGPAPLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ14</accession>
    <name>A0A2T6ZZ14_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1123076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000058">
        <property type="protein sequence ID" value="PUU80739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ14"/>
    <dbReference type="OrthoDB" id="2437734at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase type IIA subunit B" evidence="8">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="135" mass="15224" checksum="E87E2324FC982E76" modified="2018-07-18" version="1">MNGERIKLNFKKYCEIFINALHEAAGVEEKPVITWEVVNDRWEVAFAASSGNFQQGALKIQNKSGAAVTNAHMRNHFFIFVNCLIENPAFTSQTKEQLTTISKYTGLGQPTANWAKRSGPQHPDKRERGGCRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ32</accession>
    <name>A0A2T6ZZ32_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_974024</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ32"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ32"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000050">
        <property type="entry name" value="Vacuolar ABC heavy metal transporter (Hmt1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="348"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="669"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="909"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="961"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="909"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1006"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1085"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU80695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122275" checksum="699E2C53F37C6D29" modified="2018-07-18" version="1">MGNYTNVASPGDAYHSSALLARDVVFYTHYAYPVSLFFFFLVTLTWWGISTSESLKPTPPPVTGIYENGKRKKKRQSEGRTNSGFFGRIAERFPGGAKAKGKKVADDKLTPLRKAAFNWLLIGVIFTLVANSTNVILHALTKKGWWCGKDYVVCTVSLLFIYAIILISQLDNSLYPTLPHLTSWFFGLVGEVVLLVANIFTYEEKHGSLIGRSDASVGVTKKRFSLHNWDIVDLSIDLLRIVFLVLLVGLYICLIVLSKQESDDSDSEESSSLLASSSSSTVDGVPDYGSVPAHRKHGAPEPSTHAPAGWGRRAVVGKQSWWEYVQGYTIFFPYLWPSKDRRLQFLMIICFILMVLQRGINVMVPWQLGEITNALSGSDGELPRLPYVQILLYIVYKFLQGNMGVLGAARSMLWIPIGQYSYQALSTSAFEHVHSLSLDFHLGKKTGEVLSALSKGNAINTFLEQVTFQVVPMLFDLIVAIVYFLVLFDAYYALIVAIVTLCYLYITVRMAQWRADIRREMVNRSRDEDAVKNDSMVAYETVKYFNAEGYEFGRYRDAVRAYQKAEYKVLFSLNIMNVTQNLVFTIGLVVACFLSAWQVSTGAATVGNFVSLLAYLAQLQGPLNFFGTFYRSIQSSMINSERMLELFKEQPTVVDAPHAEKLTKCEGEIAFKDVHFSYDSRKPALRGLDFVAKPGTTTAFVGESGGGKTTVLRLLFRFYNIEEGSIEIDGKDVRDITIDSLRSHIGVVPQDTVLFNESVMYNLKYANPNATDEMVYEACRAASIHDKIMGFPDGYNTKVGERGLRLSGGEKQRVAIARTILKNPKIILLDEATAALDSETEQNIQTALRELAKGRTTLVIAHRLSTITAANQILCLHEGQVVESGTHDELLAKNGRYAMMWRKQIRAEQKQKKAAMKKDDESESSTEDTDESLIDLAPSHPSKIPGNDNILESEAVTPEMIDTPPGELSTMPAIPSAQDTVGGGPSTIEAELTPKTAAAEMVGEESPVMSPVTSPVTSPVTSPGSPFRKGKGKDREGLRRSGSALSTSAGGSGGGPPSSSHGKWSARGLRKTLSLKSSVLHRRSASSAGSGSPSGSERGSERGSERGIDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZH6</accession>
    <name>A0A2T6ZZH6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZH6"/>
    <dbReference type="OrthoDB" id="4175694at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="28178" checksum="3089BA84A77EA984" modified="2018-07-18" version="1">MSSPISAESHPPARISPFVPAGILERAGIKHCIVGNAVVRLYGSDLVIADLDLAISDEQVGLALSVLHDEGFRDVDFGPGHLVFLPVLGKPGGWVACRLQFPSSPDYVVLSLASCWHQEINPDTTFLPCPDYRFPRFLAYLEALICTIDALVSVGDNPSLPRYQYAIMMVLLEKRPELKGMVSPGDQFFIDFFMKQRARSGKLRVLELRKGIMAGTISVDAARAVVPRPDSSRRRIKEKYLRQGTRGGNGEGSTPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZP7</accession>
    <name>A0A2T6ZZP7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein transport protein SEC22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1099993</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZP7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZP7"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000007">
        <property type="entry name" value="SNARE complex subunit SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000014">
        <property type="entry name" value="Transport protein sec22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="16">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="17">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU80925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="25011" checksum="59575F2EFEEAA30D" modified="2018-07-18" version="1">MVKSTQIARLDGVPLAATVDDNQAEAELAEVKQQCKLIFKRLNQHSEPRASIESGPFTLHYIIENHVCYLCVCDKSYPRKLAFTYLQDIAAEFYSSYGNELMNPSLRPYAFVQFDTFMQRTKRTYQDTRASANLDKLNDDLKDVTRVMTKNIEDLLYRGDSLERMGDMSTRLRDESKKYRQTAVRINWELMLKQYGPIGAVSLVVLFFIWWRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZR0</accession>
    <name>A0A2T6ZZR0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1100023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZR0"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR GRISEA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="618" mass="64227" checksum="5DB7A81F2F76B5C8" modified="2018-07-18" version="1">MRGHRSSKCSHTDRILVKVRKPGRPLSSCPHTLSSSSPGTFVHSSPGAISNGGGTTTKMNTYGEAHRGNGCNCEVTSVAIPKLTSCVCGISGPTPKSHASCEISKSSSCAEANPVPSPVLSQGSSMFSINKVAGSRHRVQRKSIAGAEGSLARRASLIGDDATMELLLNAQQEAGSPDVRVEKGSKYGVIETNMMGAKTGGDGRSRYTNGVSCASGAENGFSLAHPEVSIQGREFPVAVDPTYSPSNGAPTPKFDMGNGVMPVDGWNSALDLPFFREAPPTHAPPMAKPGGGCCSSGRLVSQTPQTNIGRPSTIPKPVASCCNGGGSHGGNFVAKPELSRMPILNPEFFAPPQYNPAYSTTSPLEGSLPRPTEPSTLTLTAREFAWVQYLRATGFSSPPPPLGAGFFPDLETMSGGEENRQSTECNCGPDCNCLGCISHPYNPRTVEYVKGLRSFALDDQSASPFHSQSNSPTLPSPHLSGSVNGMGEAGDSTASAHKHTGTTKANINLIIKTPPPPPSPDRESSARASENGVSPSAFVLVDYQIGPCSEAETECKCGDGCICLSCLSHGKNHEAEMARSARWDASGLGGAGAGMAAGPNWWGFGSSGSVETNPWNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZV2</accession>
    <name>A0A2T6ZZV2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZV2"/>
    <dbReference type="OrthoDB" id="5420075at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="32891" checksum="90334811648C1033" modified="2018-07-18" version="1">MLLRMEKCRIRAFIRDVVITLATDISRTRNRIAREISYVKNIKQAECPPSTRSHEDDPEASTLRKIKAEAPFGTLGTAGKRPHPSSVIMAQKFGGEPPLRLLPVREVVDIEKYDPEAPIELIPEGYVKQYVIDDNDNGRTSIVLLEDPSYNGYRPKKRLAKERPDTPNKLPRDNVPQTRPWQKIASSPTPTNPISHSRRRGGAQGGQVLIPEQVPRLMPYSQSQEATPVPTDRKHNWAAESGHNAGWRKDGTKNGIESDGDDEHDKDYRGDDEDETEYAGSGGTETDTEYPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZW4</accession>
    <name>A0A2T6ZZW4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_662208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZW4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20956" checksum="27DCEDA564FE0A57" modified="2018-07-18" version="1">MRLEEKPPENVVTGRDMVYWYFDWVGMGSQVWGLHSFCLQFLSTISLLSFFFCFLSFPFSRTLGVMSTNFLFHRFIVFIFTFFPIGICVGELLLFLVLPYIIRSYLTSHHHLSLALLEPFFFSFFPFFPRMWVCFFRVTLKGSFAARRIVYANVAVGSGAFFFYFLITFWRVLACGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0B2</accession>
    <name>A0A2T7A0B2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_641890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0B2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="80" mass="9643" checksum="66E562EFF184AC33" modified="2018-07-18" version="1">MGSDFDFFVFMDTVFTLVFFLVRFFFVLLNSLHTCCFLAFYVYAMPYFLALLLFYRHYHVLSIVFRGKKRENPRQDAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0K0</accession>
    <name>A0A2T7A0K0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1099799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0K0"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="124" mass="14137" checksum="C5C334B1966D81E9" modified="2018-07-18" version="1">MAAVFFLVTNQTVFSMIDFLGKTSFSFVGKQSQTEELKRLQKIVVGLKLTLAFEVQYLVSIYLVKFGMLFLYSRFAKHTKHITVYLRITQVICLVTFAGCILSLFLSCVPIRTFWSLSNSNGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A272</accession>
    <name>A0A2T7A272_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_970476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A272"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="141"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="261" mass="28195" checksum="6ACEB1F6AAB64BAE" modified="2018-07-18" version="1">MLLERGDVNSDSSDKFGWTPLSYAAGYGHEGIVKMLLERRDVNSDSSDRFGLTPLSYAARDGYEGIVKILLERGDVNSDSSGKNGRTPLSYAAGYGHEGILKMLLERGDVNSDSSDNNGLTPFMHAERSGKIGVLPLLSAPRPFSHRTSQTSDPELKVASPPPPAQEEAETRSITQQEGIIPDLRPKIAEATPPPIPDQSPLNQRQAHLPVSAPAHISSGVPSAQEQVDPGPVSQQQGTLPQILLEMLLTMLEFLLFSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A340</accession>
    <name>A0A2T7A340_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A340"/>
    <dbReference type="STRING" id="42251.A0A2T7A340"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="160" mass="16895" checksum="8866E979B701B8E3" modified="2018-07-18" version="1">MAATQTAPSLSIGVILLDNHELLDSTGPIDLLTNISYHFLSQLPQTEAFLPLAPRLTWHYISHNLSPMSATGGPQLLPTTTYTTCPPLDVLIVPGPDALAPLRDDVKEFIIARVEQVQAVLAVCSGSIVLAKAGVLAGKSAMSNKILLKAVGKDVAFGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3H9</accession>
    <name>A0A2T7A3H9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_968729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000030">
        <property type="protein sequence ID" value="PUU82307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3H9"/>
    <dbReference type="STRING" id="42251.A0A2T7A3H9"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="210" mass="24090" checksum="A799844F973BC8A9" modified="2018-07-18" version="1" fragment="single">TYDIDSFIAKAKYLSVAKRGLRIQFSPSCLHNISSDIHLYSDVEERLLSGNILSRQVPLHHIPHFYLGLLPSSIHLPLYVFLPSLWNSSSPNSSYISNHHIQQWMDLALIPAILRHYPQDIIQHLPVSFNSVSMSIFTRGRESGTQSGRFESGKRQEHHYFLPGRFLKEVWEDILKFSMQPGYTHFGNAFILIDAKDLKLHLKSSTMEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3P5</accession>
    <name>A0A2T7A3P5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_429050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3P5"/>
    <dbReference type="STRING" id="42251.A0A2T7A3P5"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00806">
        <property type="entry name" value="VINCULIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="267"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="417" mass="46289" checksum="12D66C702F6FDB63" modified="2018-07-18" version="1">MNFLQKGLAGLESRLDKVLLDEPGGQTTTTPPPQPTLQQTKAEEKAANTAAVKAGRISLQERLAAATARKERGRSRSPIVEDGEPVESLKDKDKDKDIGREKEDDNKEGDGRDSSSCKPEPSPPTIAQESPARPPTSKPVTDPPPALPPPPEIIISPRGSLETNGYADVSHEDLETTITLLREDLTLCEARRQEESHAAAERIDALEDKIRYLARESAEASRQKANGAPSGLEKKLAEAQEKIALLLEEGEKLSKNELKLQNSIKKLRTKAQEEEKATAEAKRRAERAEKEAIDAKEKAKRAVENEKRASERVKGAVRLESEVEGLRREKESSASVIAELKGKLEEVTDRAEDAESRVQTEALEKERKVTVELKAEIERLQSEAALTEERLQSEVRDLKAKMERDTERARIMEEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A495</accession>
    <name>A0A2T7A495_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_389680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A495"/>
    <dbReference type="STRING" id="42251.A0A2T7A495"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="19947" checksum="F4056673039BA88A" modified="2018-07-18" version="1">MSFLDLPNETILQIAREQAFRDLNSLLRTNQRLARLLKTALIDNVCALREVETCKRALYAAANRGDKAIVQRLLDRGVLEFVGQGALLNDAVLSVEEAGLRVLLECGIDPETRDGEQQTPLCVASKNNRLEAVMLLLDDQRVDVNSTDRSGRTPLSLAAGDGHVQIVRALLEDTRVDVNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4X3</accession>
    <name>A0A2T7A4X3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4X3"/>
    <dbReference type="STRING" id="42251.A0A2T7A4X3"/>
    <dbReference type="OrthoDB" id="5367228at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="421" mass="47429" checksum="46E5BC4F88AFD0D1" modified="2018-07-18" version="1">MSSTIQAEIAQEAIDVVTAEPDVGEGGLSQEKEKEMSKHDGRGSTSKEETEKPLPKEPKKESSRPQGKESANASNGSEESRSRKKSSSKQKAYAESRFRRADIVERCPWTEYEMSIDDLDHHFDKLRTLPSLFDKIHELSEENEKLRALQDDMLSGIDRFHPTPDSAIVEKVAGLRGLIRIYSKTFSRQLKSIKEGASVQDRLKSRTLTMLIDDSLWEDSRNIVLLAESVIWKKILDDIFWSPFQVFGERLEDTWKTIFDEDGVESADAYPVASEQSEKWRNATVLHLATKVRKNPDKASSIAMTILEQLEDRLCSILGIDSLKASDRDSLTKIVTDSCEFAVLLGQQRCRLRFYIPEAGLHFDATDNKEKLETIGSEEIQFGKVGFVSAPGLRKWGNGYGQNLDELDVIVGARVKVVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5B1</accession>
    <name>A0A2T7A5B1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1151966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5B1"/>
    <dbReference type="STRING" id="42251.A0A2T7A5B1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF322">
        <property type="entry name" value="HELICASE MOV-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="414"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="683"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="906"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112734" checksum="F413E871E5966463" modified="2018-07-18" version="1">MSPSTPLRIVPPSPLASHAAGYVPNTSHTPVSSTSQAPSTTPMSYAMVAGGGNTPTFSPGVFQPPVSRTPQQASLPHSAQQQHNQQQGIATQSGFHPPQSFRPNPLQPPFSPSGQLTSGASSSTAKPWQPDVYTLPFIPHYLQAINTLPAVLVASLPAPSIPYHSFISSFCGSAFLRPLPPAPTVPPVPSTSVLASSSDLTPAIYSEYFLNLLSHEVSAQHKEFRKYDLFNVPIYIQEPSQSLYRLVIPGIRENNPPVQLGDVVKLRQVRQPGYMAMGGTFTGYQYDACIYGMDKTVGYIVLRVDHLVLESGRFNVCFVVQEKQWTGATRAIEDLGTELRGASSREVAGNPVEGAKVNGVEANNRPGVFVRRMLFPEKEDGIWQTTLSRGIFKRRWFDGELNYEQQQNYGNVPYLISGPPGTGKTKTIVEVALQLIFTPSNPKHHILLCAPSQEAADTLALRLVPYLNPRVLFRLQSSTRTFPEVPSELLPYSYIANDMFSLPEWKKLMGFRVVVCSTRDAEILVEARCTNKDLARWEKSVFDSLRGIGDESDGNDPTASGVVEKGQIVNVHWTALLLDEAAQGIEPEVTVAVSVVVPPEEASVDKPIFVMAGDQRQLGPRTVSRVPQLDMSLFERLFLRELYSQHPLARQSFTHAYEQSPRVWSAERILERKKALLPYLRPPFTNLIRNYRSHPAILAVPSALFYNDTLVPEASNTNYLEGWSGWKGRRGIPVKFCLNGGMDEWHEEGVSFYNLREIKIACNIAKDLVSSGLVAPHEVAIMAQFREQIRRLRRALRSPAYNLRDVNVGPIESYQGSEHRFVIICTTRSRERFLEGDLGRGLGVIFENRRVCVAMTRAKQGLVVIGNPWILGKDPVWRAWMGFCWRHNSVEKDPFEDEEADKAFNPQVNGNENSQPNKENPSLPNGYSNHTSGKLPAITELKVNSWQPPEDERETPQYISRLETALVYRSRVNNGYTGALGTVHGGFDEDDPMWTAGIVAEEAVRGGIGNGDLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5G3</accession>
    <name>A0A2T7A5G3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_965889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5G3"/>
    <dbReference type="STRING" id="42251.A0A2T7A5G3"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="28734" checksum="EDF1A48F6197092B" modified="2018-07-18" version="1">MPSRALGRNVHIYSARDTNTVLGGLVATDGMTNANFYSMVEIIFIFDSDYTLCRKKSGTTVPRDNDLLQAGKYLINTAGSLKVNNEPWLVRTRSVVAGAPPKVFIQAVRERDFRCVITGQPALNAEYGIWVGFTVTPIFPLAHKQHWATHDYDSWITIPGSRGSIHSVQNGMLLRTDISILFEAYILSINPDDGYKVVSFMRDAKGVAGTHLDKAFLEDPERPTDELLRWHFRQAVLANMRGQGELDFDSRSPSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5H2</accession>
    <name>A0A2T7A5H2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">OPT oligopeptide transporter protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1039914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU82992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5H2"/>
    <dbReference type="STRING" id="42251.A0A2T7A5H2"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="749" mass="81041" checksum="7BB57CA4490C8953" modified="2018-07-18" version="1">MSSNTYEIRGGIETPLGGEKHDLYEKHEARDEIDSIESEPAPDFDFFVPFPIVEGAPEETHSQILTIRAVLVGCILGGLVNASNVYLGLKVGFTFAGNLIGALFGFAILAAFSRTLGQNFPILGGSFGPKENSIVQTAASAAGGLGSIFVTAIPALYQLKLLKDPASDFPRLLTFTIVSAYYGLFFATPLRKFFIIHTARELRLIFPTATAVAMAIRAMHSISRSAARDSKRKIKVLTITFFVGIMFRVGSSYAPGVLWDWHFFTWIFIWSGYTNQALAVENWGWFFELTPALIGSGMLVGLNTAISFFAGSVLAWGIIGPTLVSKGMAYGVQTFAQGEPGYDRWKDLVSFTSLNLKDPVNHPSPRYWLLWPGVLVMIAASFAELFVQYTLIWFAFKSAWKGIAMGLNTGVRKFGRRSPFLEKHSHIETEHMVEDPASEDEQVKLWQWGPALIVTVIATCIVLGLQYHMNVGMSILAILLGFLLSFLVIQCTGVTDSTPLTTAGKASQIILGGVSSGAGLPQATAERLNLIGGAIASGAASQSTDLTADFRIGFLLRTPPILQWYAQAIGSVVAMFMAPSMFLLFIKANPCILNLEAEKTCAFSAPSAAAWRAVAVAATSPTLPIPRSSVIFSICFAILAVMVVIARHNFLTGHREKYRVYVPNFMSMGLAFVLPQTQLSTAMAVGAIFAYIWAKRNPVSFDMFGYTIAAGMMAGEGCGGVINALFEIAGYGSSRYGVATGCPGHRFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5H8</accession>
    <name>A0A2T7A5H8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU82997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5H8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="10260" checksum="66A6FC7E5BC2FBD5" modified="2018-07-18" version="1">MAAELTTVRTDGSLESKPRGRCIQDLYSESEMASGLERLGTSLLGAISNLKKPLFSPSDTWKRAMTEKKSEGFDLDKPGYEWRPESPPPLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5W0</accession>
    <name>A0A2T7A5W0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L31e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_212217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5W0"/>
    <dbReference type="STRING" id="42251.A0A2T7A5W0"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="13885" checksum="04F1DEC23AE1A644" modified="2018-07-18" version="1">MPKAPKTKPGRSALADVVAREYTIHLHKRVHGVSFKKRAPKAIKEIKAFATQSMGTEDVRLAPQLNKEVWKRGIKGVPFRLRVRISRKRNDEEGAKHRLFSYVEAVNVKNPKGMQTTVVDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6A7</accession>
    <name>A0A2T7A6A7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6A7"/>
    <dbReference type="OrthoDB" id="5471817at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="412" mass="45580" checksum="FC2AE31B615B6F08" modified="2018-07-18" version="1" fragment="single">DATLVRRTPAARVRIIPGRAYTPPAFPSSSTARYSSPLGIPSTTTSGVRSSSPPTSELTTPQPGASGRNQLMAKHGDRGRRRNSSRGKISDLQYTLFVDPLPDPVTLTSAVHGVWSRAQDEIADAGNIEASEKVLTLVEYLLEEDRFMCPSDGYEEITFRFLAPQIADAIYECINETIVCLTCAILCHTLGRGELGHSLTLRSSSLRPSERNIWRGFPRATQELMLRNLREMIMDKVNQENRVLKERREGFANNHEAVHAELERQLSSRNPRRPAAREPTPINTGARGLVGRLESQLERELSSQEPRRAAAREPTPINTDGRVLEGHQESQDASQESAKSFDFSQSAFARALRGLDAESVTFDDSLDLTLEQEQESAANPDLASRLSLNLDDFQEDQAATGENVRQNGDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6I3</accession>
    <name>A0A2T7A6I3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_965048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6I3"/>
    <dbReference type="STRING" id="42251.A0A2T7A6I3"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="248"/>
            <end position="249"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU83346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="307" mass="32643" checksum="205F859D8FB98B97" modified="2018-07-18" version="1">MSTVLPVNGNHERNAPSTDFTVKTGLARMLKGGVIMDVVNAEQARIAEEAGACAVMALERVPADIRVQGGVARMSDPRLIKEIMEAVTIPVMAKARIGHFVECQILEALGVDYIDESEVLTPADNTHHVAKHGFKVPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHMRAVTGDIRKAALMSDQELYTFAKEISAPFDLLKETAKLGRLPVVNFAAGGIATPADAALMMQLGCDGVFVGSGIFKSGNAAARAKAIVQAVTHYNDPKVLAEVSYDLGEAMVGVNVDDLSDSQKLAKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7C1</accession>
    <name>A0A2T7A7C1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl transferase domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_962914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A7C1"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08955">
        <property type="entry name" value="KR_2_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="1"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1311"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1427"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1541"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1502"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1283"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1298"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1408"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1502"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1621" mass="173578" checksum="0053D0909C82F9EE" modified="2018-07-18" version="1">MDPQQRICLEVAWEALEHAGISPNDIAGSDAAVLMGVNSDDYGRLMLEDLPGIEAWMGVGSSFCGVPNRISYLLDLHGNSIALDAACASSLIAIHHAKQLLENYESEVAVVGGVNAMCGPGLIRVLDVAGATSPEGRCRSFDAEAKGYGRGEGAAVVIMKRVEDAIRDGDQILSVVKGTAVGQDGRTNGIMQPNPQAQAEVYKKALSAAGFDASTVDFVEAHATSTRVGDPKEVSAITSIYGSAAGRTAENPCYIGSIKPNVGHLEAGAGVAGVIKATLALHYRQLPPQANLQTLNPAVDWANSGLEVVRDARPWPRPDQTLRAGVCSYGYGGSISHLVLEEAPSRETLKEEENNGPVILTLSGPGEKWYKGQAAKLAEWLKTDGAKIPLSAIATTLSTRRAHHHVRASIIAENHEGAIASLEKLSQGIDDPTIIKARTVSGNTKNDVVWVFSGHGAQYPSMGVELLKTEPEFAKIIDTLEPIYQETLGFSPRQALETGDFETTDKIQALTFAMHVGLAAVLKSRGIKPAAIIGHSVGEIAAAVTTGALTLLEGARVASIRASLYGRPDVAGKGAMILVDIPFEDVEKDCASRKDINASIHASPTSTVVSGTPEAIKEYSDYLATQQQQVRVVKSDVAFHSPLLTFLGPALTGLLGDTISPKQADIKLYSTSDLDARTEKLRNCEYWINNMLGPVWLTSAVKAAAEDGYKVFLEVSAHPLVSHSINETLMEIGEDESVVIPTIRRNHPAWEGINTALGRLHANGAVVDFKKFVGKTWVPSLPLTVWQHEKYWHEVTLDGTPGVSGSVESLAHNLHWTAAQLESTSAPLNNVVFVADKAHSLLGPFKKTLTKRGLGVKVIESPSELESHSDVLHKTGTVVIVLPDELEDIERLPQTNFANTLKLLETTKRLNTFNSSAKLWVITEEVQNAKSEYSLAAASMLGLARIIASEQPDLWGGLIDIDEPAFPFQVLKFIHKADVVTVRDGVSKIARLRALPKASLTPGSDLKSAIKIRPDGTYLITGGLGALGLEVASWLAEKGARRLVLLSRKGLPLRSTWSNVTSGPNADIINKVKTIEALGVAVNTVSLDLGKPGASEDLKKALDNLSLPPVTGVVHAAGIMEDALIHEATEQSFKNALTPKVDGSWALHNAFPVGTLDFLVLFSSCGQLFGFPGQGAYASGNAFLDALASYRRNAGDNALSLLWTAWNGLGMSASASADFIDAEMESKGITGVTRDEAFRAWEYAAKYDVPQVVVVRSLPIDEGATPAVPILTDIAARRPPPEVDSESEEDSEDEEESAPAAAPSNPADLKKHLEATIKADVASVLRLSSPDDVDTHRPLSELGMDSVMTVGLRKQFKDTFKVTIPPTLIWAHPTVAHLTKWFAENAKVSAPSATATSSAPKKSKSPKKSAPSSSGSALPSNPADLKKHLEQMIKADVASVLRLSSPDDVDTHRPLSELGMDSVMTVGLRKQFKDTFKVTIPPTLIWAHPTVAHLTKWFTENAKPTTSSPAAPTTSSTKKSKSTKKSNTSSTGLSLPTNPAELKKHLEKQIKADVASVLRLSSPDDVDPHRPLSELGMDSVMTVGLRKQFKDTFKVQIPPTLIWAHPTVSHLCKWFAENLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7G3</accession>
    <name>A0A2T7A7G3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_783049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7G3"/>
    <dbReference type="STRING" id="42251.A0A2T7A7G3"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="299" mass="32946" checksum="E9C415E7F8CEE119" modified="2018-07-18" version="1">MSSLYRPIVAIAGLNGSLGQQTLKALLSPEFINDFQLPIRVLTRNLSNLDGNVYYSADMAQYLYADYDDPEVLDAALEGVDVVINLLGMYPRSWIRLGEAAYRIGAKLYIPSEFGPDHRYFNYESPFAEKQVQSNHARGNGIKSVQIFCGIFMEHSIPSGGHLGIDLPGRRVTAVVQAGRPEPRVTFTSVRDVAMTIASVASRSPSSLPDTIRIAGDTWTLRQLGEYYQSLIGAGVHITTQDYSTFSQLVLDQNIPVLDQSISGHYQLAAGAGLLDYSNEWASAGMWQWRSIQHLLAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7S0</accession>
    <name>A0A2T7A7S0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1060706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7S0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="558" mass="63192" checksum="CED53DC2A26582DC" modified="2018-07-18" version="1">MSSHQTISKRFDTPESSIDTSSTNASSTGSREWPLKKFSSDNQSHRNLVVLGWRFLFTFFSIFLLAICLWQFSKSQSLSKWEQRSFNMLSILFSGSASLGLGSLLGYLGSMFRWPLLARTMHQMQDVDSILELLDSVSNGLREYAKIPEWFTDYSREDPEFGDNSSYSLSGLEISNSTLQVGTSAVIYSYQLKDFQEGYTILSNRTIHSVASYSLVEVKQDQYWRWDSWDRTGPFNWGSRGDPDDVVSGVLWVSNTSRSESIATGNGSAFPNYWVSPLNFYDQAPTRKSSQIYIVCENLAWECSPTLTETTTPESYQIELHERLFHPTSLYWLFGLGEDLGPYVQTTLGEYAFYVDEPGSRTFTPAALDGLERICLQNFTMPLNETRWNSYTLWVSGLVARLPILAITYANTELPRYTRDTHSNKTAGTAYLHTKLEVNWHRVTLIAVCIIIGQILVIIAVLYYCNGIYTRDDSHLAAAELLKTVVTRFDDGKLMTGEELAESLDDVLGVPVSYGTRKGQVDGPPEVDLASGLDTNFPPFPRKQQFRRILVEKIPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7W1</accession>
    <name>A0A2T7A7W1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1071686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7W1"/>
    <dbReference type="STRING" id="42251.A0A2T7A7W1"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="135" mass="15651" checksum="5888EAFB8C091093" modified="2018-07-18" version="1">MKFLKNGRVAIITRGRYAGKKVVIVKVMDDGSKAHPFGHALVAGMERYPAKVTRSMSKKRAAKRSKVKPFIKIVNYNHLMPTRYTIELETLKGVISQDTFKEPSQREEAKKTIKKAFEERYQTGKNKWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8W4</accession>
    <name>A0A2T7A8W4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1070707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8W4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="348" mass="38489" checksum="30F28EA3A0A75CFC" modified="2018-07-18" version="1">MNLSKSGPELKYVRFSIANNAQRKMPSDFARRASIALSFRSISHPHAFTLRLIKHSTSSFIKLFMSRLILVHSEGLQGRLFEICGTSRLERNILTVRISISPKILPVNSLHKLSFSPSMPSMRMYTGSVRQSLIAFRRTFHKEHRLVKNLSPCFSSSALQPSKRFPSCWRVLYSRSLATLASLSCDNSASSEDVLAVGSSGETKWKIKLTPSGGVSGPLRNSAATRLANILFPVPGPPQSQSSFDSLLSCHPLYTASSKIHFPVSPPGRLYSSRRWSKSISGGDTPQPVHFISSSKVATQILSHKFKTRIGNAVFSTGQSVRPGPGRGRTTFRRPVPSFCQLARQVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Z8</accession>
    <name>A0A2T7A8Z8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8Z8"/>
    <dbReference type="OrthoDB" id="5419633at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="22169" checksum="9B0F7F28030061CA" modified="2018-07-18" version="1">MTTASVVTVAVASDGFFEYRQSPEGALVFGRILGIARVVDGEIYQARVRARRRGEFARDLFFNGRGGEEEDRGSGEDGDDNDGGFVEHFDERDFTGDEVRLGSIGGGYYAGESDSEDMSIAQGLECGICMRREISVQLRECSHPLAEVKEVGKLGTRVPGFGNACRHGERRFHGVEMGRVKAMGFGRRLVNASFTNGRDSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9I7</accession>
    <name>A0A2T7A9I7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9I7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="10787" checksum="256FD9C3208EC893" modified="2018-07-18" version="1">MGPWLSYDPLTSNNRDLVPSSVGDGISSLQKERKRNSSMPDAPPVLHSLTHSMSTLQCRTRMPGARPPSYLANSRNFHHLRFPASGNLRVAVAGRVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9J1</accession>
    <name>A0A2T6Z9J1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000704">
        <property type="protein sequence ID" value="PUU72157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9J1"/>
    <dbReference type="OrthoDB" id="5414731at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="579" mass="63106" checksum="B1737870E6DFA44F" modified="2018-07-18" version="1">METLSKQNRQNRDTTPKSPSGLSDDSLFQSEKFIQPMTQPSASALDESSRDAETFGGMGEATFDARSKHPMQFHNGYYQPTEGAGLPTPYSQPVPEGNPLGRLIPRDSSPIFADTVLSENVRKRFLFAKNQRHIPTPAGSGESSGLSGQNRPTPNTHKRGDFVNYGASAMFKENKRIEDTGKEFSAPVQGPSDGQFQNQNLSYNSPIGFANKYMAPIPSSASTISPSFVEAHRPEGRGVAFKDPIPSHRDRQAPHSHVFMDKDGEGGSKFVAEQLIPLHSFSPEKLVPRYPMDSSASLPQGHPPAKKFSSSPVDFSERGYQQRLQGTTLEAPSIERGGDTTTPHSSNPGVEEFIARQSAKARSRPLYWKTQCHWTMKPLGDPAGNCHYGRSCLYGHEGDVYNDNLSVYYTFENGRSCPNFVAPVTPSPPLGAQSLSSPWVVPEANPQAQALQARENNQVLGDPGASDSRNAPGHYMEGGALVQPDFPWLHQSQQAASSSGQLASPTEASSMSPTEASFSPAEASFTVDESLFRREPRVSVADFILGNYEEEFQSQTFGNLVANMELQYPMSDGSGPDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9R6</accession>
    <name>A0A2T6Z9R6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1096835</name>
        <name evidence="2" type="ORF">B9Z19DRAFT_1097733</name>
        <name evidence="1" type="ORF">B9Z19DRAFT_1097854</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000669">
        <property type="protein sequence ID" value="PUU72201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000626">
        <property type="protein sequence ID" value="PUU72237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000489">
        <property type="protein sequence ID" value="PUU72663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9R6"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9R6"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="501" mass="56220" checksum="DF70F4D93676F65A" modified="2018-07-18" version="1">MASPSLNTTGNPHPLPIPDIEAKNYYYGLYSRPVLVARTSSDTWMLPSGPEAFLKPKELRPVNEHPLSDVWEESLAFEIHEVLETNEVKWTSTDLIRIGFMGESAAPIVIWIGVIPGTLSCNQGQRVAKECKQLLVMHDIIVTGYINAKLRKPVSSVDPTAPLVLPLTPTLGLSICNTRTPLSEGTGGFFLSDDKSQLYLVTARHVVFKADIKNNKLYKCKPPSKPPFEIALFGTAGFKNYVAWIELAVKKKHIVSELQASRVKAVGECQDRVDTDEHELELELADTAKQMKEAVDTIVAFEKLLKDVKQVWGKHFQPDSRPYRILSSNQTVDRYQEIYSPDQLTLMISNPKNHYNFTYPPDRLLKVRGIIPDAEMRKPKCMMGIISVPHCPETWSCYGLTLGCATGIKSFLRNYFSDSPPKVSKEWAILPFDTKLGPFAAPGDSGSAIIDPLGRIGWEFRIFRYHLRYPISFILESLKAHGYNVTIDITLPSEGGIRLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9W4</accession>
    <name>A0A2T6Z9W4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_715725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000607">
        <property type="protein sequence ID" value="PUU72265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9W4"/>
    <dbReference type="OrthoDB" id="10664718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015457486" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="389"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="47554" checksum="A8133A1C7352F680" modified="2018-07-18" version="1">MKSSLCIAPLLLLQFINLTWALPWDLQTCPLPVPPSPHVQYILPSDVGIDGNNTRKKIGFAVTKIINLLLPRQTVVCRLANCDSQNWCCNDQTYSVSNNKWTCLAPTRYQPVTSTYQSTATSTITSTSSITSTTWNTVTTWTYISSTDVWATTVTVTKTITQTSLTTSSITLTRRGMPTPTPTRCVRQTEDKEKRKRGLADGANPTSINWITITVWITAPASTIYMSTTWSYTYWITGQTTITQTTFARVDSTTTITSTYQTVTTTTSTVTDTTTTTENPSPDSSPSSSPSGGGGGGGGPSIGVKVGAGIGAGVGGLVIIALLAMLIWRKYTKPTAEEEWAGNQPVEDISAPPGDAGPGMAMVGAGGMVLAAGANDKVPYKSGYYDQGGNGVTTGTSPSPPPPAPPPAAYFQPVPYPQGYPDPGPNNTSIHTIPRRPVPGSPPPPGYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA28</accession>
    <name>A0A2T6ZA28_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1097414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000561">
        <property type="protein sequence ID" value="PUU72362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA28"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA28"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39615" checksum="58C0008E82D5E619" modified="2018-07-18" version="1">MARKAYDSPAPIFDNRFVKVFWYKPNAEQNGATAVAAAKHKEPSPVPDEMEIDMEEFKKKQEEAQKAHEAKMLKKKANEEAAKELERRKEELQRMQLEERRKLEEKLAKKRARSAAASASPPASGTSPAAGGSSKADAQAATTAALEAQLRALQAEAQSLGIEGSDTVPEYGSYRGRGRGRFPFRGRGGYVPRGGGVYAPTYGSYRGRGALPTARGRGGTLKLDNRTRRVTVSAADLRGSKDEEFRHYLMNTGLEVEGIEPHPDKDDTQIVAFKDRRTAEKFIYTGNDIPNIGEVTLAWFNAPPSNPSPNKPEDTSRMDIEENGTSSSAAASSSAIHHHHINSNDHGDDDVYEDDEGRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAA5</accession>
    <name>A0A2T6ZAA5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1010292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000550">
        <property type="protein sequence ID" value="PUU72399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAA5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAA5"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="144" mass="15901" checksum="6D8AA9C10A088048" modified="2018-07-18" version="1">MGSTTFKGNGSQKEADCAWRPQKSRPLGTGWPTLVIECGVSRSHPRLAADAHWRFENSGGQLKIVLLISYSASKKEIRLQQWELVTIPDPHVTHGQLKPTRTAPAIMREIDLVAGISNEASLMLNFESVFLRPPAKGEGDFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAH8</accession>
    <name>A0A2T6ZAH8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000518">
        <property type="protein sequence ID" value="PUU72502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAH8"/>
    <dbReference type="OrthoDB" id="5499569at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="17378" checksum="A1E8BE5182496BAE" modified="2018-07-18" version="1">MQSFSNLSTRPAPTPVWGFSSLYTPSPKSQKNDGDKTTDPGRPRHDYHGMALTDFARVVTVQMDELIATFKSYLEMKAKEVPAQYLPFAEAVGKAVKLYQKGDISKTDFRLAISSLKHNPVQCVAFWKMSDELRIDWIIERAKEMEKGSSNTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBB7</accession>
    <name>A0A2T6ZBB7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1096590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000466">
        <property type="protein sequence ID" value="PUU72781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBB7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBB7"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="9">
        <location>
            <begin position="163"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU72781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="43776" checksum="16E10EDFC9BEDCB1" modified="2018-07-18" version="1">MATTISTPAPTDLNTTMLLLASADHNTSVLTSLLKTSSPNVQDPDSKRTPLHVAIAGCNKDDPPKKLRAAEDTLKLLLQNGAIWNDLDGGGETPGCIAYRLGLKGLYEVMVEAGVRAELVLARLGGWEEIDDDEDDDDEGDEEWVEKEGNGIEAAVGAVAEEKDVNSENYLKSELKYHEDKLLDSDNNGVMMEWERNIMERSVEALLPGEKPGRSIMNIGFGMGIFDTLVQEKNVTRHIIVEPHKDVLKKMKEEGWDKKPGVEILEGRWQDVLDPLIRTGETIDAIYFDTFAEDYSQLKLFFSEYVIALLSQEGGRFSFFHGLGADRRISHDVYTRVVEMDLFDAGLETTWETFELGEGEGQKEQDWEGVRRRYWTLGEYKLPICMFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC55</accession>
    <name>A0A2T6ZC55_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_580016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000418">
        <property type="protein sequence ID" value="PUU73063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC55"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="52" mass="5576" checksum="C44FDC02C630F839" modified="2018-07-18" version="1">MNTAADFAANLFSAQAACTVTPNNPIKFWRETVNLNGISPFNGIPHTRPTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCB5</accession>
    <name>A0A2T6ZCB5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1164903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000413">
        <property type="protein sequence ID" value="PUU73086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCB5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCB5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="54" mass="6225" checksum="EC611C834E8B0A01" modified="2018-07-18" version="1" fragment="single">MNLPPIMRGGPRPAPTLIPKAMKPSRSRRKRTPMRIDAETIERRQPPPEDRPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCK1</accession>
    <name>A0A2T6ZCK1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000399">
        <property type="protein sequence ID" value="PUU73222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCK1"/>
    <dbReference type="OrthoDB" id="10383967at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="218" mass="24019" checksum="BD93588EC4F95BAF" modified="2018-07-18" version="1">MTGQIPPYLLVDILQNLNTEDLLRTQSVSRTFHEKLTTQALLRRILFTLPPCLPPTTQVPLETTYVLHPLFRLVDYIPGPTPIYQRAILRDSGKEVSQYSVCLTFACRPTCTKIEIEMCGGVLGVEDPEGVSVIGVFAGLEALMNERHMNGRLCWDCVQFPFAGFRTPLTPSTGPPKLIPEFHNLPEITRQLSHGGVATSSLVTFGGLDTAPDIISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCQ0</accession>
    <name>A0A2T6ZCQ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1163864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000396">
        <property type="protein sequence ID" value="PUU73253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCQ0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="21149" checksum="8AF03A08AD3C7070" modified="2018-07-18" version="1">MELRKEVDWVKLEAELKVWKGNGIVWSKGNWDRKELDRMVEELEDGLGKRMEECRGRRKWKGGRKRWWNEELEVKRLEVRGLEKDWERRGGKERKEICVKEMKVYRKMVAERKGEYWMNYLEGLELLDSFGFVKTDRDFLTDVPGIRREDGSLEERDKGKGREIIRGLGKREELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD54</accession>
    <name>A0A2T6ZD54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trimeric LpxA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1135175</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000378">
        <property type="protein sequence ID" value="PUU73403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD54"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD54"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="125" mass="13789" checksum="37CCCE75BB232031" modified="2018-07-18" version="1">MAGDGMRRPEYGVPITIEHCYLPGNVIVLPGVRIGRASTVSVGSVVKEDVPPGCLVAGNPARVIWVIDKDAVECFQRAGGRRALEITRPKVPSAGEDDIKGLMQRLQRLEVEVREVKEELKRRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD84</accession>
    <name>A0A2T6ZD84_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="11">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="11">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="11">PHB:PPT</shortName>
            <shortName evidence="11">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1095018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Mitochondrion inner membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
            <orientation evidence="2 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000375">
        <property type="protein sequence ID" value="PUU73457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD84"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD84"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU73457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="412" mass="44525" checksum="633D6DCCA5352B77" modified="2018-07-18" version="1">MAIRLPRLGSGVVGQAAYRMGRMPSRFSPRNLTAITRSPPILHYKPTPTFISRISTTSTPPTSRPPLEIYEPPKSGLLSYFPRKAIPYVELIRLDKPTGTIYLFLPCLWSTLLAGTLTDPTTPLPTVLGTTLLFATGALIMRGAGCTINDLLDRNIDPHVSRTRFRPIARGAITPFHALAFTSAQLLAGLAVLVQFPVETIIWGIPSLTVVAVYPLMKRATHYPQFVLGLAFSWGALLGFPAVGLGLDGLVMATAACLYGSNVAWTVLYDIIYAHQDVKDDVKAGVKSIVVKHEAHAKYIMSALGVAQVGLLAGAGAVSGCGPVFYLVSCGGAAGSLAYMIRKVNLKDVKECWYYFKWCAWAVGFFAIGGGLFGEYIAVRSGLYGEEGLWGLGGRRRRALQSAENKDERIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD96</accession>
    <name>A0A2T6ZD96_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD96"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41229" checksum="907A6CE2DE73B424" modified="2018-07-18" version="1">MHSSHRPRHNNVAPSHSPNHTSTSSPAPHSSETEEDSSRDTYTISTCSPLASPAPHTTSSTAIVIPTLEAPQPASPALRDTSSPAPLNSPPALPPSAATPPAYQKVPPGLETSLPIAHTPALPPLAPLSSSQATSSSPGLVATPTHPLRPLISSSSKYYSPSSIKKESRSLTASVNRRSTRATKRPVSYAQSNLATLVILKSSDNNRKPTDFQASSYTKKYGNPIGTAGLTQLKPATFTICDDDDDGNNRTGNNHDDEDLDEDRDVSTVTWDDGEDDDFEMTDFVDEEESGEGDSDEGNPGWYYHEEWDESEEDEEWPGQYDRNVNQQEEDRRQDDHTAQEEEEEDLDPQPATKRRMAARSKTTHKRAKLAIATTSSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDJ7</accession>
    <name>A0A2T6ZDJ7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1163006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000373">
        <property type="protein sequence ID" value="PUU73484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDJ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDJ7"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="13"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="226"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="310" mass="33180" checksum="5E3AD01E26B5170D" modified="2018-07-18" version="1">MALPDTFSEGPVRIAVIGGTGISALEAEGFTAVASLNIQTPYGAPSSPLTILKTPQNTPIAFLSRHGLHHELTPTEVPNRANIAALRSIGVRSIVAFSAVGSLQEYIRPRDFVIPSQIIDRTKGIRASTFFEGGLVGHVSFADPFDTGLAKAVFNIGSDGVLKGEGVKMHKDGLLICMEGPQFSTRAESNMYRSWGGTVINMSALPEAKLAKEAEIAYVMVCMSTDYDCWRTGEAAVTVETVMGNMHANSANAKHLAAAILEELAKEKYQDLVNAKHLEGSSKWACCTAPSARSAEAVKKMEFILPGYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDV5</accession>
    <name>A0A2T6ZDV5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1196834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000365">
        <property type="protein sequence ID" value="PUU73584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDV5"/>
    <dbReference type="OrthoDB" id="5397565at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="228" mass="24589" checksum="6AB26044DF9209EB" modified="2018-07-18" version="1">MDESLQEFVGSVKVGASAFKRESDGVDGGVGKRVKGDGDSGGNWNGDSSLLAPAVESGSLPPEVITKKRKPRARTNNPKGGWTQPEDDIILDGRKKNKSWQEITNAVNFLKDGGKARTLTAVRLRYQKVLKDRGVELTPEQLEHLRQAKRDVEGSEKFRFVAERFKELAKIEISRTSCQNILSADEKGEPAPAAKPDPESDPSFSSTTSSSSSSSSSAAHTTPTATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEQ9</accession>
    <name>A0A2T6ZEQ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000332">
        <property type="protein sequence ID" value="PUU73936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEQ9"/>
    <dbReference type="OrthoDB" id="5468182at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="20648" checksum="5CD7FDB584D93416" modified="2018-07-18" version="1">MSATGYLLFTGRLFWKKKKNLQFDHLLPALISITIADSKSGLQYNKAVGYEDLSNITWYKFICSFPDMRTYREEYKDWGNAIKCKIEQDRILGWKENTAAQWVGIQAYGITNPSVTDRAGLSQADIGRVEHFTEYLDFLLKDIAKNHKAILTRMLAVTQPVPTVTAPIVAFITIRNDPKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFI0</accession>
    <name>A0A2T6ZFI0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000312">
        <property type="protein sequence ID" value="PUU74245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFI0"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="162"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="382" mass="42450" checksum="A61446853B31A616" modified="2018-07-18" version="1">MSFGFSIGDFIAISRLIRTLVDALDSDTGSRAQCSRLSGELKSLQSALTAVWDLVQKPPRDRQPYASTINAITSEIKRCRELIEGFNAHMKKYHKSLCNGGSKRKVKDVWREISYKIFMEEDVVMLKDSLRRRVEAINLLLLVVGIRSQHPKIKELGCGIEGSIILQDAIGRTFPVPFVVCATLEMFHGFLELSFRGLPGHQKVISREYSVSDEKSQKDFTSTEWVENITPGRLVSMSVLFRHHMDNAFKSKCPKCKTPGAFSAGGNSSGWTQCKFCQLWTQHSKEYPAKTPIGVLGLGPSPPSPAPPSPSAISKELSSFRRVKLVEISQVHSSSNTQFASPPRESGLTIYGRWREFTFEVVLEGEGEGEGNAYSPIEFPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFT3</accession>
    <name>A0A2T6ZFT3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1000827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000304">
        <property type="protein sequence ID" value="PUU74361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFT3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFT3"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="40087" checksum="72B562CDBC21CC60" modified="2018-07-18" version="1">MVCGASGTGRTTFVNTLCGKKVLLSKDSDDSANAHVEEGVRIKPVTVELDEEGTRISLTIVDTPGFGDQIDNEASFGEISGYLERQYDDILAEESRIKRNPRFRDNRVHALLYFITPTGHGLRELDIELMKRLSPRVNVIPVVGKADSLTPAELAESKKLVMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEEVVEVNGRKVRARQYPWGIVEVDNPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVEGGATASMNPEDLASQSVRLKEEQLRREEEKLREIESKVQREINEKRQELLARESQLREIEARMTREHSQPVLDEKTNGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFZ4</accession>
    <name>A0A2T6ZFZ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1000799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000304">
        <property type="protein sequence ID" value="PUU74376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFZ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFZ4"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="508"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="137"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="597" mass="65629" checksum="D160A3337D49E4A5" modified="2018-07-18" version="1">MPSSPSLLQVPHEAALPLQRVDTHSSTATTAAELSYKDLEAQSGQRSLDRRQSVSSVVTQRDYVGDVLPEWERSLRRQETLQRLRTVYSRQAETLGELEAPADASEFKDVDKELVTWDGPEDPDNPRNFASAKKWRITLIIALYTFVSPFASSIAAPAAQVYSAEFGITNPTLASLTVSIFLLGFALGPLFMAPLSELFGRVIVMQVTTVLFFVFNIACAVANSTAQMIVFRLLSGLAGSAPLALGGGVLSDIWAPVDLVRAMAFFSLGPLLGPVCAPVIAGFVVQNVHWRWVFWILVIVSGVTMVIGMIVFKEETYPVVILNRKAARLRKETGNEYLHTVFEVAGDPKTSFQIAITRPLKMLVMNPVLVMLGLFLAFVYGFLYLMFVTFPIIFQGQYGESIGIAGLNYIGPGVGFMLGLALFTPLLQKIYLRLTAANNGIAKPEFRLPTLLIGGALVTIGLFWYGWSAEKKLFWIMPVIGTTIFGAGMIPVFAAVQTYLIDMSPRYAASAVSAATLFRSLFGFAFPLFGKQMYAKLGYGWGNSLMGFLALPLGILFPLFIYKYGEPLRIRAEKRIEESDAKVWARAAEKQARSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG39</accession>
    <name>A0A2T6ZG39_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1092834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000298">
        <property type="protein sequence ID" value="PUU74453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG39"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG39"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="332" mass="35633" checksum="160DFD2670A6EA8A" modified="2018-07-18" version="1">MPFRTSLTEALGIAIPIVQGGMQWVGYAELASAVSNAGGLGIITALTQPTPADLRKEIQRCKKMTSKPFAVNITLLPAIVPPDYDAYAQVVIDEGIKIVETAGNSPGPIIKKFKAANTIILHKCTTIRHALSAQKLGVDFLSIDGFECAGHVGEHDITNFVLLRRAAQSLTTPFIASGGFGDGEGLAGALALGACGINMGTRFMCTAEAPIHENVKKAIVAATEDDTELLLRKWRNTSRLFKNKVAIEAKKIEEQSVTGKFEEIAPYVSGKRGRNVFITGDIDEGVWTAGPVMGIIKDIPTCKDLLQRIEKEAEVSIDRISRLVVPAPISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGD0</accession>
    <name>A0A2T6ZGD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1133145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000293">
        <property type="protein sequence ID" value="PUU74548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGD0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8475" checksum="663A71E1045AA8B3" modified="2018-07-18" version="1">MRASLRVFSTSEAGLLALEDLFFLAAVIFWRPVFTESGNVINDSRNTSYNGLYSLLGTDTERAGSPSVNAFEQARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGR8</accession>
    <name>A0A2T6ZGR8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_410690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGR8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="20067" checksum="4C1DF663A5D24FB3" modified="2018-07-18" version="1">MIPRVSNDDDRGEMLARAISSVKASVWLCWRAGYPCWWNSGNDHVRRRNNNRGVSQCSVLLTLSIKHLLITEDKPFFPFFFLFSFLFSFLSLTLSSTSHGDAFLHGPEICSIRSCFSGTCWGGAFRLTPSVSIIRRLTAGHGKTIILLHATKIPRLGQFLAVCNSSPFYKHHDIASSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGU1</accession>
    <name>A0A2T6ZGU1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_413502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGU1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="23075" checksum="76546EAAD74834B5" modified="2018-07-18" version="1">MWPLTISEGKIHAAWVGPLAGWPLVNRTGGGGGQGSGGMFYVQYNDNNMADRFPFSSGFAGQRGRRSGLHCFPDCCFCLLLLLACLLVACLPRSFVRSFIILPVSINSFPLLILYSALACLAVTPLPLFSLSRLLSHSLFPTTTTTTIPPSPRCSFAVSVYSQSLSPSFPVNHPHLRPYGARSYPAPAPHTRRASFLCLFPFGSPPSKQAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGW1</accession>
    <name>A0A2T6ZGW1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1156984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000277">
        <property type="protein sequence ID" value="PUU74725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGW1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGW1"/>
    <dbReference type="OrthoDB" id="5492657at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="237" mass="28328" checksum="8460B18F6BEF8A7C" modified="2018-07-18" version="1">MRREEEEKRIWKEYWKRERKGQEYFGDGNKMTEGHDGKRVESIFLFWMRTGHGRMRGTRYGNKEKRCECEGWENRDHVLLYCWNWAKEREDMEEMWKEEGEGEDGWLDMKWLLFGKKGVEGVKKFGRETGWMELRGKERVIWDKGILERKGVSLRNVLEEGRKLSETGEDRRRKLKEKNRMRMRLMRAKGWKEKGRKSKGREVTPIASVTPLGAKAGKNRKVLGVIDGNVRRKDGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGZ8</accession>
    <name>A0A2T6ZGZ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGZ8"/>
    <dbReference type="OrthoDB" id="4121058at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="22351" checksum="D53808205A934D40" modified="2018-07-18" version="1">MGLLNSNVPQADKKTLNYYLNFTWVPPRLTGNWCKAQLAHYGIKPLSGSKQELKRWLRVAYNEGLLKKQPFEIKLLKKYMRAEWRSKRDDNGGGVEKEGEKLPLTGKRCKMQLAHYGIKPLRGSKPELERRLWVAYNEGLLKKQPFETKLLEKYMRAEWRAKRDDNGGGGVEKEGEKCGGGGEKLGGKVVEEEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHC0</accession>
    <name>A0A2T6ZHC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_997069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHC0"/>
    <dbReference type="OrthoDB" id="5385276at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="194" mass="21867" checksum="FA5BD25355A14AF5" modified="2018-07-18" version="1">MNSTVHSEWQKLRTHTSIPQDCRFSNFSRPHTPPSLSPSPTPSQCSYYTDHCDDADDFQIEEIEDECGDSGVEFLVGEYEEPSPDYRRDMYDSDEDDETQQEIVYSFGMLSAGLGPSSIARAMAQQQPKKAKRSYTESVGNSDSDYDSGFDSQTSERRIRRRVFRQRGASLEAASVGTSYAGSQTSDYEVDMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHQ2</accession>
    <name>A0A2T6ZHQ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_377381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000256">
        <property type="protein sequence ID" value="PUU75020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHQ2"/>
    <dbReference type="OrthoDB" id="5424776at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015704824" evidence="2">
        <location>
            <begin position="22"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="201" mass="18973" checksum="9CDA306E092E15CE" modified="2018-07-18" version="1">MKSTQVLAAVFLTFLPVLATAQGNSTTTSPAVTNITSSGSTKPTTLLPTGTHTANTTATGKPGTNSTISTKTSGGADNSTITSTPGKNGTSTTGGKNGTTTKAPTGKTNITSTIVRTNSDGSLSTETSVVVVGPTETGGAGSGNGAGGPGGSGGSGSTTGSGAKTTDVAGLNNSGVGSLRAGSVVGSLLLAGGILVFGHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHR5</accession>
    <name>A0A2T6ZHR5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_996436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000254">
        <property type="protein sequence ID" value="PUU75038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHR5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHR5"/>
    <dbReference type="OrthoDB" id="9974841at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="82" mass="9372" checksum="05CCFB29EBDD46C8" modified="2018-07-18" version="1">MIQRTAFRSAFATTRAPYLMARRGLHATPARLGGYHYPEGPRSNIPFNPHTRFFYLRFITFCAVGFGFPFGIAIWQTSKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIW0</accession>
    <name>A0A2T6ZIW0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIW0"/>
    <dbReference type="OrthoDB" id="5410526at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="37049" checksum="687926FCE3E10C5D" modified="2018-07-18" version="1">MSWHKRNAPLGSESEISVECLISVLQLVRRNRENPESIAWAGQYNILPGITTNLSPLIMKAISGDLRIRSEYYKDKEKMVLSLRGLENLCFNIPETVRMFLFRPEEESRFDETILVKRTSAIKLGRNHIIPDSALHINCPAVPFMVIDVANENSASAVKHRLDAYIEAKGLIRFALILSTQYVDPQQKPAKTFFIGKVLISAYEITYSGAQTLLYKTEIWPRVPQEELIVDRIWEIHAHIPLKLFHDSICEFLGDGYGIITGTARKAARAIFHGLNFSHEEDDEEDEPEWPIKPKCTEINLGRRITVWRKPSSNPPYLAVEHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJW8</accession>
    <name>A0A2T6ZJW8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1109867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJW8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJW8"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="57872" checksum="494B10D5F29B4512" modified="2018-07-18" version="1">MQAAWSQRTPLPRRAVPVPITPRRLSPPGASSSSLGSAGSIGGSASASNDQNIDLLFAHSSARIVSFDASAPAYASGQLIPWTSATERTIASGPIRIYKTIPHNIAFLHSGSALRPVLSKSQCWNVDGRGVFCLQIRPGSYWRLEILENPDEDAVKAIEFKGVLVTILAYEITTCPFLRSGGCVTEVNAVKTLEPSKVWRRPRATTLDIEIVKEEEPAMGEEMFKGVGEVEMVEESAEEECAGAINGDQGQRDSGNESDTTTLVHDDEMDHSISSVDVGPCEEVLKEALTELKEWHDFSPPPRSPRGSMFLSRSCTVPPQLSDTNAFSTISRPSSRPSTPNSNVPISPIRWHTPTPQLREIRIPKRRDRSLSAVGLDLSANLAPEPAQISPAPSTPTLWSGSESEDNWSELVTPQRPSLYRNTYSTMDPHSPTLSRSASSLALSKTAGFVGATANLMIVKPSSYIASMMFSIASKITTRAVSGAAYTLAGRYGPADFLDSEEEFDYVDDFGVRLRPGRKDHWDKDVWGPENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJX3</accession>
    <name>A0A2T6ZJX3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000214">
        <property type="protein sequence ID" value="PUU75798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJX3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="10948" checksum="93B922C692FB1679" modified="2018-07-18" version="1">MPSNKGSDITPPPPPVKTYRLCHEWEDLLGCCLVLWSFGFMCFLIISYNIYDFNVLEYLLGLAKLGSECGFGYAVITVILPTLYYISCTTVSYGAIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKA0</accession>
    <name>A0A2T6ZKA0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_992546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKA0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKA0"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="11">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="121" mass="13179" checksum="7A9A4C758395F81E" modified="2018-07-18" version="1">MTTSLGTLVFCAPCGNLLDPSISSSKLTCEMCGHITTDTGTKTVTTTSNPRAFPSSLRLKKSAIQSLAAEDLQTEAEIQQACPECGNEKMWFYTLQIRSADEGATVFYRCEACGHRFNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKK7</accession>
    <name>A0A2T6ZKK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_292301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKK7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015754871" evidence="2">
        <location>
            <begin position="22"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="245" mass="27244" checksum="B06295CADBB14BE7" modified="2018-07-18" version="1">MIMFPFFFLFFLPFFCLFVQAVSLLDNGFISRCMHDCKGDEYLISYLSPSPLSLPNSNPQSNQQTIYDSKPFFLDLVLVLSLARVFVSSRAANDTYDTRLNPPPASKPRTLQRLATDSLASKPASKQSGAYRRRGSLFSLFSFFFVSFFPLLVSPLFISGLPSLAWLGLAQRDTLGSITFKGKSCICAPTYLPVSAILEEGMCLGMWIFAFRIGCLHVWDLIIGLGIGIGGWINNVLWNTGTHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL55</accession>
    <name>A0A2T6ZL55_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin binding aldehyde oxidase/xanthine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1102496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000196">
        <property type="protein sequence ID" value="PUU76218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL55"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL55"/>
    <dbReference type="OrthoDB" id="3886845at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908:SF161">
        <property type="entry name" value="NICOTINATE HYDROXYLASE HNXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="136" mass="14473" checksum="CF006985132F7C96" modified="2018-07-18" version="1">MWQQNGQLFTRGPGTYQIPGFADIPQVFNVGLLKGVKWAKLRSIQSSKGIGEPPLFLGASVLFALMAAVKAARETVAAVKAARGSVAVDAQAMGIVQLDSPATAERLRVAVGDWIVQWTKVEAQEGEKGFFVDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLF4</accession>
    <name>A0A2T6ZLF4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000192">
        <property type="protein sequence ID" value="PUU76319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLF4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLF4"/>
    <dbReference type="OrthoDB" id="3563855at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="457" mass="54216" checksum="E7E85D5B914405BE" modified="2018-07-18" version="1">MEKLEKSYTHSRDRVLLSLKTAIQQRRSFGLRQEHRVSFQLFQALKERADEIQFSELPDSCYMQNSEEILHFLYANFLRFGLALEYTASKLKACSFEQSHDLSRILRMFLQLQKASFTNSLLESQGDLWRSQTAVGVKNRSGLGLKNQLAAYKFCWLSPAMIDWNKWTFGKSFSQSTAFDYIQIHPTALHKTNHLLYQKSQWEILERFAELLREIEDCSSHETYRILAFLGTMVIQKFRIDVCTALFKFCDSEWKEDSETKREMALKGQLPLDYDNVLSFSPSRFARIKYSNKHKLNLQERWEILFHTQDKWEEQDLRKAWKDKPYRLYFEKCYTLISEACDAKTAQCWEYLLVQTQFARANFLLPSPAKHSFLQKQTQVGQVSKIYWVPLQHESWPLSVGWRTLPVKGSQGDQWKKWSIDYYSPIPEEYESPSNLFMEKLQPQQVLDRFLKKILHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM21</accession>
    <name>A0A2T6ZM21_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_990265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000185">
        <property type="protein sequence ID" value="PUU76537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM21"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM21"/>
    <dbReference type="OrthoDB" id="5419268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="408" mass="45870" checksum="E908945AD45D93EF" modified="2018-07-18" version="1">MYAYVKSIATKCQLLKFVTVLADLTKKKNHQRQIRKNLLKELGLSSPATGDQFSAGNNIPIYEVAIQSQECQYPPHHHWIYEQEDIGNQWRSHLVDGKMKDKRNPRYPLHLLDPQKLQLDIPANESAIIIDSTTGVLVGLVLRNFSGGNREVLEWATGVALEATEWQKSVRVNNTGSIVIEGFTAGQRSCPKFNWVNNLNYKFKNKPIEVINNQRCRVALLFGLGWNLMKKKSHPTVVDDFQTYVKTHGLPRMTPTGQNGYSIKAGSQILEFPGEECAPPSGCISTNFSRYMHTEKNGNQYVAFWNLARTHGTEAGANFFIASYGIRICNSPDSHVAFRAADSHGTSLPLRTNDFMQTGPAFLIGNRLAQQWKKFVQGAVSDKEIEDDLVDDHADSSDEVRLSRGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM26</accession>
    <name>A0A2T6ZM26_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1066533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000184">
        <property type="protein sequence ID" value="PUU76542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM26"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM26"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="7">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="197"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU76542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="440" mass="48238" checksum="87DDF6DAB5DED99F" modified="2018-07-18" version="1">MPVSSPPPLSPSSPPPDFIVPLLPPPPTRSNTLPLMPKPQPQPIRICVPPRRKTVGILLLGVVIFLWVLSTFLTFTIFSDGSYTKPYFVTYVNTCSFCSYLLPGVWRRWWGKCGEGERRRGGYARLEDVSLPGAGGEDGDGVVVVNKGLVVEGEDMLGERETIMLSLQFCLLWFVVCFPPYASRTYGITMLMNGEKANYFQSYCLKWTSVASATILSSTSSIFTLVLSALLRIERFTWTKFLAVMLSLAGVSLISSVDLTPSSSPSPASEGKTPGEILLGDLMALMGAFSYGVYTILLKVRIGHESRISMTRFLGFVGLFNFLGLWPGIIILHYAGVEKFEVPPDARVWWIVVINASITPISDYCWVYAMLLTTPLIVTVGLSLTIPLALLGQMLVLGVWSSGVYWIGAALVFVAFLFVNRESAVGDGGGGEGEAERWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNK7</accession>
    <name>A0A2T6ZNK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1128834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNK7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNK7"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="587" mass="64239" checksum="28F7FFFE325ADEBF" modified="2018-07-18" version="1">MAAVSTAALTPPSSSHGRSTGGDWNLSVPVDGTDTPDPTLREHDPNTPMPPRSATDRRTSNELRHVQHAKNVVPMATITPTTPNVYSPQQEHQYSPGDENYHAYSAVQASDYNRSVSPEYLAAPRAPMLQRQDSTVSSNHDGDSVFDLYGGRLSTVSGMSAGSYGRRSSGEEGLPALVNGDGDHAVDEVEADSSNWIHSDKLAEIEAVDSGGGIKTKGKDETDRSRWIDRDKLAKIENQELQQAGIHSRASSDGTYMREENESFRDGKKQRVASQSSVEDRSELYDPEGFSFDFRTPEEQAADDTPVQAMPSRQFRRHPSYSRIPVPTSSPCPIPQGYIERSTPLLRNSLTPNGSEDDRASLSGVYHRARKRSHSAGSAFLLDDQEPATPTPGPLSNPKNPSRSPVSHGNRRASRTPSQLRKDRSRSNPQLHNRPGTSGSHATHAGGAGSQASGGKHHPEGPPPWSLQSYKPDPSLPPDQQIIPTVAKRMQQEQWERDGAYASVYDRELRPLKVPSDPNLDKENGKAGDMDEPEWPLKSPALQPEPPVEKPKSDAGYKTVPTVSANLLFYFLLSMLVWGVWDGMVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNN8</accession>
    <name>A0A2T6ZNN8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1087003</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNN8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNN8"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="15">
        <location>
            <begin position="71"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU77098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="458" mass="48101" checksum="F6645BC8232AD8AD" modified="2018-07-18" version="1">MPSTTLSPAVPNNYTPPQSPSPSPSQYLSRQSSHTATSTVDASKISFLPSSEPGSHPYDSPTLKIDDPATLEALKNAADLLGQGKCVAFPTETVYGLGADATSTVGVNSIYAAKQRPLDNPLIVHVGSLRQLRGILAPSDSTTNTNGHTMNTDGGEIPEVYDALISKFWPGPLTILLPLPTNSPLSAAVTAGQPKFAARLPSHPIAQALCHLSSLPLAAPSANASGNPSPTSASHVFTDLRNRIPLIIDGGPCSVGLESTVVDGLRDPPVVLRPGGISVEAIRELGGVWARTVTSRASLDDAADSSIIPEAPGMKYKHYSPRAGVILYEFGTRPPCGKDLVRSTILSGKNFNGKVGILRTRTWKAGIGELTLDCLRSESSDVKSEFYGNEGVGGLTVVEMGLGKGGEEIGRGLFAALRELDDAGVDVIHVEGIEEVHEGLAIMNRLRKAASVVVRTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP45</accession>
    <name>A0A2T6ZP45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP45"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP45"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="17817" checksum="1531934A1D99DCCF" modified="2018-07-18" version="1">MLSWQVYFPRQIPSVLILSASQKALEDWVEDGTGEGGEGGEDIDTAEEDPLQFPEPAIDPILPLNFLLAASPFAPTFMRASQFPALVADSSSNVDAAAISPHVAGPSSTKISAPLTEMEEKKVAIQEAYLVSCTNLLAADIAAVAEVFETNPLAKLAPGVELYNVDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ14</accession>
    <name>A0A2T6ZQ14_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1193947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000149">
        <property type="protein sequence ID" value="PUU77571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ14"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="109" mass="11308" checksum="A7DC57CF5EE555E3" modified="2018-07-18" version="1">MGSSGVLVYTSSMSAWGEGKDPGFLLVHTPDAVGVKSSGVRSGPWGSSQVKSLGVKSSGVKASECRVFRVSDGRERGWGVWLGMSGKVVWCALLFTPHGRVFGGATSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQK2</accession>
    <name>A0A2T6ZQK2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1085596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQK2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQK2"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU77761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="295" mass="32549" checksum="D7459C960C9167E1" modified="2018-07-18" version="1">MLFRVARPALQRVATTSIRPAQSNNYATLREIEGRLKSIKNIEKITNTMKIVASTKLARAQRAMSESRTYGQTSNTVFDKAETKPLEGGKTLIIVSSSDKGLCGGIHSQITKAVRRKLLETPDADLVILGEKCKAQLSRSSAKNIVMSFANVGKDLPTFAEAQTIADQIFQLEKDYDNIEVVYNNFKSAISYEPGSAYAFSEETIKNSANFTAFEIEDEQLVNLREYALANTIFWALSEGHACEISARRNAMDNASKNAGDMINRFQILFNRTRQAVITGELVEIITGAAASEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQT5</accession>
    <name>A0A2T6ZQT5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1193800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000141">
        <property type="protein sequence ID" value="PUU77794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQT5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQT5"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="741" mass="83390" checksum="F3BD52AC0873BE72" modified="2018-07-18" version="1">MATPEDLQANEDYICIVDQYVEIDSEGLVTVAGDVYAKGCTHSAEDALQKALEIGFPVMIKALEGGGGKGIRKVDSGLSRIKHATPFDGQLSDFGPAQVVGAKPPQRFTLLTTVLKNIIDGYDNQVIMATSLKELVQKLDPIFSQFRKTLDKFLEENIAAGDVELLMSALLPLTEIMDRYSKGLKVHELSVPLGLMEQYWSIEKLFSGQNTRDEDVILRLRDENSDDINKVFLAVLSHSKIASKNNLILAILEEYSPNKPNNGSIIKFFRPILKKLTELEYRVSTKVALKAREEHRTPHQETLKEVIDSKYTVLDVLSTFFAHADPWVSLAALKVYDRRAYRAYELHAVNYHNLDSEPPFIVTWDFQLKKPSAPATPTVERGDGFKRVGSISDLSFLVGKSEIEPVRKGVISPITFLDEAEEYHVRALVLIPLGKGAKSTGGGLMVNLEEQRRSMPLSALGTKEENDSLPAVCNVAVRDAESMDDKHLLERILPLVTDHKDELLLHNVRRITFICGYRDGSYPGYFTFCGPEYREEQSICHIEPALAFQLELGRLSNFTIKPSDKRYFTRAIVRQSRLRDEIPTADYLISETDRLVNDILDPLEIIGNNNSDLNHIFINFTPGSPLSPEEIEPALGGFTERFGRRLIICTNPKSSLAYTLRVVIQNVSRCVIQVEMYAERKTDKGQWVFHSIGTKSGSMHLSAVNNPYTAGEWLQPKSHKAHLMGKQYVYDFPELFRQAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR14</accession>
    <name>A0A2T6ZR14_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000135">
        <property type="protein sequence ID" value="PUU77922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR14"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="18927" checksum="56E4E9DA199991C7" modified="2018-07-18" version="1">MQSDCQTGDNNDSEIDVDHPIYQSLDEDRRPTAAKLLRLANDSFLSDTSTLHGGEGVGSSLLYLVYAKHSSPYTFSFWKDFNEALAFYHLVYQSFPIYNRIAVGVSSDNLCSQGPPQAQVSGYDGHNILQYQYMEREWEIERAEVPQGQYTKPKPLAQMVAGTSQTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRA8</accession>
    <name>A0A2T6ZRA8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_119997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000131">
        <property type="protein sequence ID" value="PUU78021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRA8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="165" mass="18728" checksum="279F2440D30ABC60" modified="2018-07-18" version="1">MIVVDSLLPACCNVIGTVQVSLWPGIAKSNHQGRLTALIILVAGMIGRVTGSWEGRNHWKRGLNPRHQSTILDSPRRRVAGREGDGWRIYLLEYGTCFLFSEFAWDANKYPDETSQDQALILQNNGKFSRVFGESIEARLYESLLRLILLRSYSYAYHTALIHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRB1</accession>
    <name>A0A2T6ZRB1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1115163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000131">
        <property type="protein sequence ID" value="PUU78022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRB1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRB1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="170"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="307" mass="33547" checksum="27310E5E649A05FA" modified="2018-07-18" version="1">MGVGTLLLRQATILLVDWTIPNIEQVPNLKILQLSIAGFDRVVKQPLYTDTKITFCTSNGIYSTKIAEHVFLTLLSIRNSFDQLLSQQRSNIWDDSTYPHPKDLLGFTIGILGYGSIGRQVARVARALGMNIHAYTSSSRRTPRSKIDRGYLLPGTGDPNGELPDAWFSGTDKPSLHAFLSGIDVLVCSLPLTDSTRHMLSTAEFGILGKRKAYLVNVSRGEIIDHDALTMAMKEGLLAGASLDVTEPEPLPSDSELWGMGNVVITPHIGSAGEGYLARVVDLFETNLGRLSAGERMFNIVKKGKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS20</accession>
    <name>A0A2T6ZS20_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1127054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS20"/>
    <dbReference type="OrthoDB" id="10373312at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="23263" checksum="11177E08A3112D2E" modified="2018-07-18" version="1">MTDYTPPTSPFIRRRKLLNGLRLRYPRLPRVVNRVRLPEPEIPHDPLAVLSHSFFLRPTRSLISKQYLKAVFRLERPLIYEPTLGSAERAVGLSKDILVRVGGQVFPMFAGAKWRVGFGYPLLRDFDFAGEYLRELVAEVVDVLEGRYGMDLEGSRIVFGGLGDVDLDKFKLDDLVLRHFSRTKEAFVMRFIRREAKEAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSF0</accession>
    <name>A0A2T6ZSF0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSF0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSF0"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15251" checksum="3B452ABEE9710034" modified="2018-07-18" version="1">MSLRTPECVDIYFDNTGDEALKLSLRRITRNGRVVTCGAIFRYDSGGEEMMISSKAWMNIIFMKARVEGFIVTEFKDIFPGAQKQIFQWMRQGKIRPLKTVWVAKFEELPQGMVKLLKGENVRKVVTEVIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSH0</accession>
    <name>A0A2T6ZSH0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Piwi domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1025325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSH0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSH0"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="207"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="511"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="825" mass="92404" checksum="36A34FF320E2F1CA" modified="2018-07-18" version="1">MYDIRVTAAGKKEGSNEEVKQCPPAMVGRILQTPQAKEILGDGFVFDGVSIGWATKKLPIEGDTATFGLELPGARPGRTFGCTIGIQYDGPFNCDALTNWVLREQQKGITIEALANYEQDQEVLLCLKFINSLLRKECTERFVSGQGNKSTTFFDKSRDGNTSLALNSTQGVIEAWRGFYQAASARFGQITVNVDTATATFIKPGMNFIDAISRFSGVRQEDLERGFDGNRERILEAARKFSGVGFKVKHLKKGSKGEVSRRGFRLTRLSAEEDTFQIRIWNTDDEGNKTFTLEEISIAEYYSRQYSIKLRYPKLPTVETRKGDKYPLELCFVDDAERWKELLQGAETAEFIKFAAAPAFARRSQIEESLKKIGWHNMKSLEEFGVSVKPQFIELEAKILPSPRVVFGQGTENFGPKNGRWNLRGKRFYKPATLNGYGLLYVPGGHGMRVDERGIDTFTKTCGQQFSSYGVASNPRCSSQWAMANPQGDFERQIHELISKLQTSNGVRPNLLIFILPNAAVEPYCTIKKICDTTFGIASQCMVLEKCFNPKGQLQYLGNIALKVNVKLGGSNAVIEDPFLIKQPTMIMGCDASHPSPSQRRMDTPPPTFTAISASYDRRCAKYSAVTSCQDAGQEIIQDFGAMTQELLKRFQEQAKRDPAAIIYFRDGLSESEFDKVVRYELSELKKVTKAKVSVIVCVKRHHTRFFPLDKGDKNGNIAVGTVVENGHGKDIFMVSHAGLQGTVRPTHYMMLHDENNLTAVDFQRICNNVCYAYGRATVSVSIAPPVYYANLACDRARSHVVHTNQGQSELLQVHDLLKYSMWWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSI8</accession>
    <name>A0A2T6ZSI8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1101319</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSI8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSI8"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU78451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="624" mass="70175" checksum="4DCA747F01CA3B25" modified="2018-07-18" version="1">MEDLLSTSFDLLSSYDPIHIRKGLRCLEGFLAKMCLQSPSTPSKSGARTASAANSSVVGVTSRPKDAAFKEFLRLQSGFEWNVTIRLISCLERLLGRTNNGQNNLLILSTLDLIQGMLLLHPQSRKLFAREIHMNVLLDLLDAESNDAVQCATLLTLVCGLLDNPTNTRTFESLDGLATVTSLFKRRDTPREVKLKILEFLYFYLMPEVASPSAPTRTQGERSSSRKEARVEKTTEEKQKMLGEFMSNVEGLVADLKESQPFGMSFPKDDPKKPVHLTAALGYKAGMTTIVRDLDRPGAKMHKKEIVEAVTVIETPPMVVVGVVGYVETPRGLRSLTTVWAGHLSDDLKRRFYKNWYKSKKKAFTKYAKKHADGGKEIAHELERIKKYCTVVRVLAHSQIRKTPLKQKKTHLMEIQVNGGSIANKVDFASDNFEKEVNIHSIFEQDEMIDVIAVTKGRGFNGVTSRWGTKKLPRKTHKGLRKVACIGAWHPSHVQWTVARAGQDGYHHRTSVNHKVYRIGKGDKDDNASTDFDITKKTITPLGGFPRYGEIKNDFVMVKGSIPGVKKRVMTLRKSMFIHTSRKSLEKVELKWIDTSSKFGHGQYQTKEEKHQFLGTLKKDMVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSL1</accession>
    <name>A0A2T6ZSL1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1101340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSL1"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="127"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU78482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="247" mass="26822" checksum="28A2BF07D9CB591E" modified="2018-07-18" version="1">MVDIIHPEPEHKRTSPRLLPRTHPSEAPPLSENLGSPHQKQTGSIPDMPRRRPLGRDSGSPGQAEESSADERTAIAVSSRTRSYDATASSTPKAPASEPPTQGVSTDKTPWMGFGAIELENKGSVARDHLALERTFLAWLRTSLGFASIGIAITQLFRLNAGVQPDNPKGYETMRHMGKPLGATFIGIAIMVLLVGVNRYYESQGWLLKGKFPASRGSIFLLTLVACLLMITTLIIVVIVQPSNFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSZ2</accession>
    <name>A0A2T6ZSZ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_59799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSZ2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="20567" checksum="183351A250016360" modified="2018-07-18" version="1">MLHRHCKLLVYIILVATWSRLWIRFSRSYFYFLFPSLCFFAFAFPSLAIHPFSHFLFFFLFFLFFLSLHVWGFLVPSPHPILSEPYPTCPTYDYPSPLPQSSSTEPEGRKKKFSNFGEPLESRSCGTVLSFFFLYIFPSRQVEYRKNFYDSPSQEEVVESWLGRKSRDSERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTL4</accession>
    <name>A0A2T6ZTL4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_32392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTL4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="20058" checksum="B8894223FCF2F663" modified="2018-07-18" version="1">MFSHYARRLLCLSPYRAFVSLAKPLLYSSFAWYCSFLIGVGRSVQVFWLFFFPLADLLGFFPMRPILLGLRVYFFSLHFFLSFLPSLLFAPASHTASEIAHCHKPPTAVSFPSCSLIIDYHSVRCLVHLSLVFVSFSIPLFIFFHTLHFSYPSVERSSREVGNPYLFFLQYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTR3</accession>
    <name>A0A2T6ZTR3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1064759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTR3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="19712" checksum="6E58CAA4FE52E392" modified="2018-07-18" version="1">MFRFTTRFTINRQLSIARYRTMTTPRPSIPNNSKKSVEFSSPKELLSKDKEPVSVDQGPSTYNAGSDEIKFVPLTLQTDSSIGQSVYRLGKASELTQAIGRINGNIRTIQWQNGILLMAACGTGGALLYWVIKGELAKGPKPGDVEKMINKGAKHQALKLVAEQAEAASKVTKTQAVGKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUC5</accession>
    <name>A0A2T6ZUC5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1192907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUC5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUC5"/>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053881">
        <property type="entry name" value="Utp8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22542">
        <property type="entry name" value="Utp8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="2">
        <location>
            <begin position="54"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Utp8 C-terminal" evidence="3">
        <location>
            <begin position="492"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="951" mass="102544" checksum="ABFB48D35A0452B1" modified="2018-07-18" version="1">MTANISPISLSAPYTIFALSQPIHQTRAKDREGSTYRTCYTSPVENRKRRRAGNAEVAVAIDGEGVNIYDVRSAQLLSAHVLPPTTKFSCAPVSSATRVAKTKLLRKTYAAISFPKKKIVCWEENDVRGGQDTELGSTPIAPLSRSNSSGREVVHLCDLSTGGGAGLLVAYKDGYIRCFSADLKEELWELRPPDLPTAGTLNQIPTSPEVVYAITADLDIARKTLLKNRPDVFIPGCGTEDTRESGDLVLFTVVRTGSNFQTRLSLIPTGQAAGTNASELLVSDLLVVEGDQNSIFSLHLSSATLYQLSATHLTTFSLAPTVPTVASSLRLPTGSNKTHHMYSLLRISSSTVLVTTHDDISLYDTKFSSLQAHALLHQSSASSTVTGTDPPRTSSPASGPDAKPKGQIFLTSYIQDLDLAVGYSQAGIIGVQLTRTNGRSGAKAGVRRSGLLIDSLCRGVEMVGVGISKKQASVAPGSRKLLSRLASEGRGARRVLRGLGEAKEAGDIHKFEQIFAEYVGVSWEVEGTQQGEDTAMVNGTSDMGAANKLSSMGKPVSGPAPKRDGSYSPNIYKPLRHEFVVGVLDMLFEVSSDDNSAQRLRVSFYPPSVFRYLIESGSFSETLIKSYSGLVQCLAEFDPSLRTLEWMLGVAGEIGLGEVIKAIGIGLRHGNVNVEGEDQTVLDVIRSEVMRLALVRLNSFPAEAIAKALKTGLGGQDLMDLIHLLRKELLFDRQLHGEVGVGIGIEDIGIVADLLIVALDTIGIGGLVLGNSSDEFIQELRSEVMAVVEGVQEAAALKSILEEVLRHADWRRATIEKKQAGKQKAKKRKRNSEGVKASAKENESREVELRNEIGRTAVERTREMPAKSVSVARHLINSGPIINADTSVVSPLLPLGVPPAPVSRISWVAARPAENGINFKELRQLNRRKIKEASYRESMVAGVYSVESMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUJ7</accession>
    <name>A0A2T6ZUJ7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HotDog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1082310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUJ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUJ7"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31229" checksum="DA472085974892FC" modified="2018-07-18" version="1">MPPRLCTRAFSARLNAGSLITRPQSNAGAAFPPSLPSTEDFISPTPTHLLDIALSPYLNTTLPSVLPKSPKPLPPGHHLVYFPPPIPESQLLQDGSDAHHSPTPLLPRRMWAGGSLTFNSPVETYTHALLQEKITSAISRNGKTFVSFNREIYPTTASPAAAPAIVEKRDLVFLPTTTSPPPPRRRNRLPEEPDFARKFVTTQHLLFRFSALTYNAHRIHYDLGFAAGVEFHAGPLVHGPLSIIFLLELLRAERKGRIKEVLYKCLAPVVVGEVSFRFLGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV00</accession>
    <name>A0A2T6ZV00_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_893105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV00"/>
    <dbReference type="OrthoDB" id="5387651at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="251" mass="28179" checksum="8DF2A4532D14C85B" modified="2018-07-18" version="1" fragment="single">AATTVVGPHPLRTDPPTAEKKLECLPAGKPRMAAKSTAAKQKFSSINGPHIYYDGEAQQAFYDCWTTLNSKRGLLRKEMMTIKRKKVMTLPTHNYGYDDDSEEEGSDKESDQGPKETEEERLKREEEERKKAEEERLKAEREKKAAEVLEYIDSCLDKASKGCENAAFLWLKGDICAGHITFINSRMREAMDRINLEIEKMKPVEPPAPVAEDEGIGAEMDIDTDDTPTANALPPRKMDTAMRDSRVIGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV15</accession>
    <name>A0A2T6ZV15_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar membrane-associated protein IML1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Vacuolar membrane-associated protein iml1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_833649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IML1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZV15"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04449">
        <property type="entry name" value="DEP_DEPDC5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="6">
        <location>
            <begin position="1338"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="857"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1438"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="662"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1446"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1464"/>
            <end position="1474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1822" mass="201650" checksum="4BA9FAD369D9D290" modified="2018-07-18" version="1">MVLWIHDPDGSPTLSKQEAVLNYDLFPPHVARPGDIAEVKLMSSSSTGNVSDDSIAMGGEAMERKKSYANSAMEEEGTGVGGRVGGAGGGGGSTKVEKKFLFVIRKLEPEQRAKPNLQISLARHVADLFGFHSRATVTVTIIDRNLHEASHVEIYFRDQYISRSDMWRMATTLMTDTCPYNSQKLLFISSIRGSVGNIWVRGRKVQSAYFSPQTVPIFRSESARYVLFVQMSREMWHFDTDDGGDGDQGEGGGGGVGGEIVFNKLINGFLPELFKRWKRINAHHLVSIVLFTRVVYEDGEPVGILNGNGKESEEFLGTPGGINIGEGRRYRDFYRVVVSSMASSDWTIILHRLKKEFSVFLRDILVLPITDDEFPLGSNQTTPISSAADSMASRPGTPSVPTFVDMLRPASSSTNSQPSPRIPPHKSVPSAQRKKQPRMIITGRPSAAIHGNILEAINLATLQFSQDYVDRDLVRTGISVVIITPGTGHFEVDYDMLKATTDGLIMTGMGVDLVCLSKVPLHTVPLFKYRSPIPISVLAKQEQGSPKIFPRGLSPPKVTITPSGATAPDRSQGEWVYAVPHWIDISFWSAASEKKINKRGRVEKKKEKKKSASGFRARAKMYELQMMGIMENEISEISIPFLHDNPFWKPLPTEEEQAQADGSSTKGSVKPGTTTSTTTSSKFLKEAFKWMDEYDGAAFRPLPILKARERAALDRRIDGEDAEKIEKTLEEVDPLVLGTSFHGEAPGRQVSLPGGAFFDRKMKERRPELESPIELREEIPNASITGTPSAVPPSSGLPKPSRLGLVRNISFPFKSWGAAKATAKTGIVSTEATAIAAVSPSPGSSGVMVTRGFDTSEVVTPKSPLSPRTTHLEESPTIGTSGNLRSPEKLGWGSRPISIKNNAITSLEAAGQDRDRRRSVVGSPLDRASMIRERESVDILKAASLTRHGRPSIDLVANAEKTATIPPTVSPTSALSPWVQVLNPSNPKKNTPSAVNQFRRWHHVFPKPIKISTVKWKSLCSPAALPLTTEHFPSAEQLRDEYQENPYVISQNADYDELEESSSSNREELVRAMISQRLAQGFQIVVGSSVAEATAGRGGDPDIYSKTYMVKAGSSCFMSLGSQIHQLICDEEYNVEVKRYVRKPTTAIGASKFTTADEYISYTKTATGEAYIPVKIAFRLPIAEYNWNYVDQYIGGYEDTLTEQLRYWRARFVLIPNDPPESARRGGLLGHSNGGELNDEEIRLEGIRRLTQVFQRNRYIPPEERQYEKYGRRKAKEKNPLQILYKTVDPSVVVAQELESLPLIEDPTNNMRRSQLLTTEMFEKKNLDLKAIAQELQGPKGVRLQDRRWHLRFHSNCFIGEDMVTWIVENFKDVETRQEAEEIGLKLFKAGLFQHVDKRHQFRDGNYFYRIAEAHANTPRPTSKGGWFGGFKSDKPAQSTPAFDISSSPLRSRSSTMATDEGSETSSTSGYRTPTPTPATKKKVEVELSKVMKYDIDPSRKSYRKELINLHYDRLHNPDNCYHIRIDWMNTTAKLIEDQLASWARTVDRYGLKLVEAPIDEISTIPRTYPFRSPYIFKFCLPPPPPPPTLSTVSPTTESIDLSTILSPTQPAPLLHHSHNQNDSHFYHRLALRKLGFVLDTEAAKNFPPTVSVKYSWGAPSYRHSQYIHRSGVIFCQITDDGSFLLMANRQYTIRTAMLYPPPAVALGSGTDVTPEAVKDEIESFCKDPEALRRFYDEANGRVGGGTATGPGSVMGGSSMGILGSPVIGPVGAGSPTMGTSVVHAHGVGRTTSMKSGRNSIVDLVPEDFVLGRGGYEPGPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV38</accession>
    <name>A0A2T6ZV38_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1081988</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV38"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV38"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU79346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="945" mass="106282" checksum="58AC1D4DC2A5F97A" modified="2018-07-18" version="1">MASSALEEPNGTRLRDRSKGDEKIETSTVIQEVEVIESIDNEDASKPRKTFGRTPDGKTFVVPQTHDMVSTLLSPKQPKNLSDIVILVTLAIHIALLFLLPPSLRSPVLGCLFVLWRTSYNFGIGYLLRNQSNHKRLVWWARKSGIFDAERNPRICALVKHEIEAKISDEVKSGDYIFEKTPIEYNTWLVFRRVVDLVLMCDFVSYVLFAISCAHVPAGEGWGLTAGRWIGGIVLFMFNLWVKLDAHRVVKDYAWYWGDFFFLIDQNLTFDGVFEMAPHPMYSVGYAGYYGISLIVASYPVLFISLAAHAAQFVFLSIVENPHIDKTYNPPAPRRRSAPPPVRPSSSDGKESCASSSADDYTQVVKECKIPGKFDMFYNTHLCAALLIFYLVVGAVVIPNTPMVKAIFLLHAFGWRVWHTVGIGSILVGQSHNKAWFRHFLKFGQTREEAWDQWKGLYHVSLVMCHTSFFAAGWKFYNLPAGQEGMVLFRHTLGALLLALQVWTATSIHESLGEFGWFFGDFFFEQPTPHLTYSGIYRYLNNPERLIGSAGIWGIVLITSSQEIFMLGLFSHVCLLLFIQFVERPHMEKLYGSQIRKEAGVVKTIKKAMPPPVADGVKSFQGSIDKALADVGEFIEEFLEAAKPKLAHGVMGVVKDTQLFISHYPAKLSLTFLADGLAKYDAKKYSITILNAVRETNNGVATGLSVPFGQPIKIAWTAPVNHSRLDWIGLYRIADNASREITKIASMGRWTALCKDEYDTDIAEKGIISTDIKTFSPENPNEEVLTGELEFGGDKAFWSNGVYEFRYHHDGKHKVMAISLPFEVIINKAPLAADKTEEEHFINMHEMQDSVEEYLFPVVVRCFDRDQDIAPSDVVDEFGGLGDEKYAKRIVYAVKEMFGVDFAPEVVQADGNVRRLAWRICNAKRVLAPFSMNTSGTPSPSAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVB3</accession>
    <name>A0A2T6ZVB3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide exchange factor Vps9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1064287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVB3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVB3"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14369">
        <property type="entry name" value="CUE_VPS9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041804">
        <property type="entry name" value="Vps9_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="4">
        <location>
            <begin position="475"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="790"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="759"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="724"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="92010" checksum="D0552EDEADA50070" modified="2018-07-18" version="1">MVDYVESPRIDPSGNTEVAGGEGGGGSKESIGKSNGVAVSKADGEGRFEGGDNELPIESIHATTAQGQTLDSVKAGQEARASAKEEIEMGSNPTPVKPGGREEREASQPPNASSEASMDLLPVVGEVGALSISLASLDSAPTVTMDSLIPEKGDEDYRPPTPLKDDALAKRERDATLANPPPPPPPPKDVPPKDVPPKDVPPKDVPLKDTRPRDRVHLGPSITPRPSRPGSKSASPSRRGSSQQGRSSGSSSEDEAGYSARSEIHNIFEQGSAPASGEHLHPNSSASPALAEAMIGARHPPRTSSLDGTDYLARTSSGTPTLSEKGKELDSGTAHAPTIHHPPPPDEDLPFDFHRFLSQLRHRSADPVAKFLRSFLNEFAKKQWMVHEQVKIVSDFLNFIYGKMEGCEVWLNVGEVEMDNAREGMEKLVMNRLYTQTFSPEIPPPQGNPTAGSRRYRRDRDERFPGRRGQHQEDVERDEVLAQKVRIYGWVREEHLDIQDTVTEESGRKFLDLAVNEMIKMGSYRAPRDKVICVLNCCKVIFGLLRHSGGDESADKFVPLLIYVVLRANPANLVSNVQYILRFRNPDKLNGEAGYYLSSLMGAIQFIEGLDRSSLTITDEEFERNVEAAVAQIAERPSPAASTDASREGDNEIMNEKGDRSGPSVTPRVSSEQTRFSTSSRESNDSSTSNGDDEKLAVAGLLRSIQRPLTTIGRMFIDEPATSNTNTAAGGPALTPAPGNSPRGSPSAEDSLLTAVGGRRKREDKLTAAEAAARQASAEVEQARMIERREHESVVQVLQNMFPDLDKEVIADVVRMKQGRLVLFFAGGVIEDLRKARLTVGQRWISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVR7</accession>
    <name>A0A2T6ZVR7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1100765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVR7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVR7"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="630"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="821"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1054"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1057"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1090"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1119" mass="124689" checksum="B9477F14C9C5FA21" modified="2018-07-18" version="1">MGNVNGKLEDGPALYLRDQSRLITNAQKRAILRITPSSFPCSKIIAKKDPGDDSLVEFVQDPDPNAQPPFLLKLTNEDDLTFNFTFNIRRKDDAPGNTGPETNINGLTFIVASNARDLENLVTREFHADPNLHKNPNVNLVGDFSTDGSNAVQFEWQWSWRPPQGMEDRRSMGWRNTCSFVEYDQRAHKLSTLAQFSFWVQNTSRGWPPSPGPSSDYLLSSPPKVRSSSGYSPESKPTDLSAEAEPPSPLVESFDGSTLAPSSISAPSVKVDNCPRPVDSTMAEDGPLFRATIKSLEQKTGTLRTKMKKVLKRAEQARQAQIVCNDAVKAFMESLRDAASTGNASGIQPALDHYFERTYREILTFERQNEISLQRLIIDPLTKLYNLDIKQAEVKKKDFEEESRDYYNYVSRYLGIRNDSAKEKKKIESETKYQTKRKNFELKRFDYCTFMQDLHGGRKEQEVLSQLTKFADAQARSYLATAKKVQELMPQLEALSYEVKESDKEFQLQRTEREERRRVLEKSNKTYVEPDNLPSFMPPPTPNPTSASPSEILGHNTGFEKLGVGTSSIRAAPETVLSLPPNGLGLSSGSTRLTAPEPSPVNATADKFKGFRDLQEKEYTSNGPINGESDRRKEGLLWALSRPGSHADPKGLNKQAWHKYWVVLAGGQLCEYSNWKQKLDLHNDPINLKMASVREARGAERRFCFEIVTPQYKRVYQATSEEDMNNWISAINNAVKSTIEGGGSVRNFDTSYVENDAGPDKLKNITTALTGKSPHYHHSVHGTNPMSYTSASNANMYRRTTVGAKPTNVRRNSSNFNEDPEKLLQAVREADSANNSCADCQSQMKTEWVSINLGIVLCIECSGLHRSLGTHISKVRSLTLDVTSFTPDLVELLCQIGNKNSNTIWEARFDATHRPDPRSSREQRLKFITSKYVDRAFVQPLSPTLSQYASPDESILAAVKNNDLQGTLYALALHGSPNTVDPATGLHVIFLALQAADPTPTIPDNELVTPSTSLSSVTFPLAELLIQNGGEITSSIPSSGLSLAAKHYLSQKTAKRASAPAEATPSNAAASSRHSHQSSSSELYEPPATLRERQQREKERLQKRVSSGGRLHRATQLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVS0</accession>
    <name>A0A2T6ZVS0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1081325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000087">
        <property type="protein sequence ID" value="PUU79598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVS0"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="107"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="710" mass="78883" checksum="0640CA1EE780AF74" modified="2018-07-18" version="1">MNSSNETARRGSHGLIYDPATGTYTRPRKSPQMVPPPLPPKETDPSHSSDYIYSPITKETHQVAEFGGDSDAGGFDLEASSKGERRREKEKQKAKRVPKKKRQLRILSLDGGGIRGYSTLVILQELMHQVYVQTHNGKGPRTPADLPRPCDYFDLIGGTGTGGLIALMLGRMRMDVESCKEYYVQLTRYVFITDKTVLGVPYGKTLFKSSRLEEAIRHCVRESTKFDTDRIIPHSPPPTSPPVMTHKRTDSWADRISPIRRRTSSLDRGQTRGRRGSSGNRKAGNPEAPLADNRPGRCRTFVTAIYKGTPPESAAPPVLLRTYPSAAESVPSYDCTIWQAGRATSAIEYAFKPITIEQNTFLDEGSGIYNPAAQALEEARNNEFPGDEISVFVSVGTGKRHEAPAQSPGRHRSSRSERHHLYHSNHSTASLTQEKTSWWGGLISSPFEGFTEARKRLYSKVDDCERVHRILIDGEDGGRPGLAKMGVSREDYYRFNVEVGVGEFALNEWNRLTEVSTGTRRYLGQRETSGLVRECASKLVRIDKANTASIEESLHPKRPSKETAPLAPPARPRPSSTPPQDIAELSAEIDHATADWTSPTHDTHPAFRLTMPDHRQHIPQSPTAETMTTYQAMVPEIQVQGPPQLPPKPGRPPYHEEHPYYRAAGELPTPNPEIRVTSPTTVAGGDSDEERRGGVPLSGGRRRRKNSGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVX4</accession>
    <name>A0A2T6ZVX4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_810578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000086">
        <property type="protein sequence ID" value="PUU79625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVX4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVX4"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU79625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="191" mass="21685" checksum="8C50121089517857" modified="2018-07-18" version="1">MAILAKHPPLFVRFLGWFEKPETLYIAMEYFKEGDLAKHIGTPLHQETVQNITKQILEGLKVMHEQGIAHRDLKPANIFVVTMSPVWVKLGGFGVSKRIRAGATTTFHTQVSTPVYGAPEVLGLDSSSETSDYTNSVDIWSLGCVIYELLERKKLFVSEFQLSCYFFGKWPLPEDRLRGLSPQQTMSEFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW19</accession>
    <name>A0A2T6ZW19_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000085">
        <property type="protein sequence ID" value="PUU79675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW19"/>
    <dbReference type="OrthoDB" id="5285218at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="72" mass="8459" checksum="FF51EBEF3A56788B" modified="2018-07-18" version="1">MGFLDKLQSKIELFRLEQRYTKRKRRTTFISDAQYVDGEYVYKSYHPSSPSKGSFRVSEFGTGNTRRPSNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWZ2</accession>
    <name>A0A2T6ZWZ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000075">
        <property type="protein sequence ID" value="PUU80008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWZ2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="10890" checksum="430759FBFA89F77A" modified="2018-07-18" version="1">MVDLATDSEESGDKEGIWDSAVNMPVYVAADTEEEEGSREEEPLISGEDIGDLESNHEGDNIDVGHREGLAGNMVEVFFQIDSHKEPAPPTSRKATLEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX14</accession>
    <name>A0A2T6ZX14_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_976442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000074">
        <property type="protein sequence ID" value="PUU80028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX14"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX14"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="133" mass="15470" checksum="32DCD65E3D8E4B38" modified="2018-07-18" version="1" fragment="single">DSEADKISLLFIYFPIIQTEVYTFVKLWNNHRIRHQRNRPSLPTGKPSILFFTPPPGIQDYQYCPDRTLLAQLEAEVSSWDPEEYLPPETYSWCCACLQAANVSLDPHLTLSTRHADGSLIVTFLVRERWCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXA5</accession>
    <name>A0A2T6ZXA5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_976006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXA5"/>
    <dbReference type="OrthoDB" id="4097086at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025122">
        <property type="entry name" value="DUF4048"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13257">
        <property type="entry name" value="DUF4048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4048" evidence="3">
        <location>
            <begin position="223"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="476"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="513" mass="55107" checksum="F64ED8A940BB46E5" modified="2018-07-18" version="1">MGDIASMHSLESAECSLGAAETTADQTPSSYSSPSLRDSQKPPSPLQRLNSPSSSPGALQHTRSSSIATSAPTRKSLSLSFPILPANSGTSPRNVSPVTSSPSGYTFQSSTPGIEDITPDDPMAFLTALAAQERRVLELKEELGKAETELGKMKRQWAVHEATRKFHDVATPIGRLRPLDTSSTCDDRERIISPTREQYNARKATLNSLNGTGTRKVLPSQRHQRTLSLLSTDRSVYKQPFAQPSDLSDDSPVSDKPPSVRRSQTFAQTSTPLSSSASASPRPLSMNDFPRSAGQKGQEALLRTGKQMAEDFKEGLWTFIEDLRQATVGDEGIHSSVNQTGIRASTNAPQDSNNLTSTASKSLNKKSSRASLRSITPQKMSRENSKTPSTTKEVETEKLIDFSSPTDEDPKSPRWSTTSTVLSEATSATTPSRSSTPRTSTSSTTSNNPLWSSVINTTQFNLKKTATALITSVEKSLAPLPNETATTGYYAPGNDAGHLRSRSGSPGAKSKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY95</accession>
    <name>A0A2T6ZY95_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1079368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY95"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015371177" description="Hydrophobin" evidence="5">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU80444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="12360" checksum="9B2ED48FE26AEC3E" modified="2018-07-18" version="1">MVSIKSLAVFLFAAAVTAAPLAGEKKGDSTDITFTKNSCEAEQKIHCCNDDGKSQNAGLAAILNNAQIKCNNLGVNVLAVPTLTDNSMCKGTIVCCPGDNSQTGLVNANADLRCTAPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYC4</accession>
    <name>A0A2T6ZYC4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000065">
        <property type="protein sequence ID" value="PUU80425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYC4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="231" mass="26633" checksum="C6E274DAC12F6B7B" modified="2018-07-18" version="1">MAGVPQESYRRGVLQNRRIAYSIARNDIDKTSFEPTQGKPGTGEGGCKEPWRSFLRHHEDNNSRMLQQLEKQALNLQQENEKFRRDLSARERQLDKQIEKLNTENRNLYVDYVMEKHERGRWNAALNVRGPIESIAQRAIDEGKITNCRGTQDNLNQITALGDFKTILHQEVYDQCSQQGQSVRPEAGRGRTAFCRPVRSFSQVARQVKIEDEDGRHFVVPSGHFVNLPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYJ5</accession>
    <name>A0A2T6ZYJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1123413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYJ5"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="129" mass="14601" checksum="37CF170BDAAAD167" modified="2018-07-18" version="1">MALTDSYVLWAWVLLLMFTATGLYVYRSRWLPFISNMIPEQAYHRLNPSFESDMEAGLSSDDFNLSGNLAAGDSRGGLDLASKKEVLRIMKGQRVNFDEARQIFMEQKLLKNGIAADGRPMDPRAVFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ78</accession>
    <name>A0A2T6ZZ78_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Yeats family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1100083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ78"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZ78"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="243" mass="27884" checksum="4D976548675FAF6B" modified="2018-07-18" version="1">MTEITRKIKLVTTQSILTDVAPAHEGFPMREWSIRVFIQGEKGEELPANIFDKVTYKLHPTFANPNRVVKKLPFLITEQGWGEFDMEVVLHAIDKGGDHSIRHDLNFQKNKYESIHPITFNNPRPNLVKALATSGPVPGADTTAPEENGVSKRDKRKNDGEERIKKKSRSERTFDMEKLAEGLQKLQEEHLLQVVQMVHDNKTPETYIKNDVEQGEFHVDLYTLPSHLTQMLWKFVQECGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZB4</accession>
    <name>A0A2T6ZZB4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1106847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZB4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZB4"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="5"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="82"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="599" mass="65237" checksum="A160E1771766C6F9" modified="2018-07-18" version="1">MPSGPLSLGDFPSEILDRILDYVGYKGAINLSRTSKGFYNTLYDEETGYWKREAQRVFKTPHVDSLINKVPWRYLFQGMAKAHVYTWGLDEDERLGHDRSPPKNYKRSSSSVAVPFEILRLRDKFVVDIVGGGWSTSFLTSDGHVYISGRLSEYMGMEETSATEIKFPEPISQLSSGRDHLIALSSKGRVYTCIDKSQGAQRVKFSVMASDSDSGYLTPDKIGRVTEDIGWVKKVVGGWDRCAALISGIGIVVWRPTDTGDTDPGAYTPSLRVIRGTNYLDKPPKGIPAEALVEVQKHKSIGQVLDFTLGEGYLVFLTVTGKVFAVRFNQEFDQAVPVELVHFSSPEGQSPVNRISGNFRKFAVLNKEGVVRLGGVDIVRNCVAGKTKRVKPIRRPDFASYKIVDIAFGDHHGLALTDEGEILSWGAESLMCGCLGLGDQLPGMGKGKFTDLEVIKPKVVSFRPPGEDAGSSEGEDKAKYYAFNIAAAGWHSGALVLGLDEDHARGDDGAPEGSTLEVNDDPTQIPDPPDLGFDPEALGSGGRERGHRGIRGVTSASFSARGGMSRGGFVRSGLQGLSLFSPSNVPEDIPKYTAQRNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZB9</accession>
    <name>A0A2T6ZZB9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1106808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZB9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZB9"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="281" mass="31790" checksum="9FCEB98DCF68F941" modified="2018-07-18" version="1">MYGETEDELNKNLEAPIKRGEEMARKLITEMGCSREVAKDLAVLTLYDVAILIDDSDSMIYEERGARKNTLIQFVDHITEICSMANESGLLAMRFMNGRRGKKNWTGKSQEYLNNHSYGGLTRIGTALKEKILDLFAIGNPNQRKPLLVLIITDGAVEGERPGHLKKVIRDCVNEREGAGKGFDAVKFQFSRIGNDPGAAKLLEDLGEDRDIGEYVDVLPVEFYLERQLEDKWFILPKILLGAILPNWDRLDDYNCTEVTDCLADKGRDSGESDYQDCWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZG4</accession>
    <name>A0A2T6ZZG4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1078446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000055">
        <property type="protein sequence ID" value="PUU80840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZG4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZG4"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26272" checksum="B2B06AFDE7CA7913" modified="2018-07-18" version="1">MERQERNLKVNVPIRRGEEMARKLVADMGCPLDIAKRLTVLTLYDVAILIDDSDSIVSEEGGQRKKTLIQFIDHITGIYSLANESGVFAMRFMNRGGGKKDWKEKSEIYLSEHQYGGATRIGVELKRKILDKFVIRNPNQSKPLLALIVTDGAVEGEKKGHLKNIIRDCVNEREMAGKGRDAVTFQFSRIGNDPGAAKLLTNLDEDPDLGEYIDVLPVEFDLECLLEDKCYLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZI1</accession>
    <name>A0A2T6ZZI1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1063094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZI1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="216" mass="24194" checksum="56586ABB568A60B4" modified="2018-07-18" version="1">MGLQFLFLTKERTLVVKFVVDVAHELTHRAFAHMFMFKFTSMGLRWGMIDLGRGRSSGLTGQKEGDTAFKPMSRQYRADWPTVVFECGVLESLERLKVDAKWWLENSEGAVGTVVILTVSVEKRSLCAEMWELADVANPDVTQTDPDPFITRATRTGGCKIVGETVTGAPLKISFKKTMLRDPDETLGEGDIVFDTKEIKEVAEAVWATTKTRPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A034</accession>
    <name>A0A2T7A034_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_972569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A034"/>
    <dbReference type="STRING" id="42251.A0A2T7A034"/>
    <dbReference type="OrthoDB" id="10420970at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="17703" checksum="9F7ECF30FFB2453F" modified="2018-07-18" version="1">MVVLDTDTNFVGTLFRPAIAIVIQEAFPDTAYPANHWAKVSRTNGSKNIKTLLGFNIPAFSSGKSCTISFSDASSASGSRTIQLFTTGGYPAFGDTWNKKPFTDVHKGTFQTSTSGSGPAKVLDNIGLTFPCPTTATSYGFEVQPVNDNDSVNWDITWGGFVITAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0F1</accession>
    <name>A0A2T7A0F1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1077830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0F1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0F1"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30814" checksum="A624B21E8EC48980" modified="2018-07-18" version="1">MKLLGVSSPFDPTNRFQTSSILSPVVLACARLLIACYIFAALFYRIARSAAFDGSHSTRDSFSYFTNLTYWGLGCYFAAAAMHTLVYAFSGRAPLERWPKVLQFLHSLLYTTIITFPPLVTVVYWTILAPDESPFSTLYSAWSNISFHALNSVFAIFEILIPRTERPPWLHIPFLILILAGYLGVAYITKATKGFYTYSFLNPDKNGSGSVAAYVFGIAAAICVVFVIVWLIVWLRLVLCEKVFGLKGKFSSKARGGRGDGWRGEHGKLTEEKELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0G3</accession>
    <name>A0A2T7A0G3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1077590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0G3"/>
    <dbReference type="STRING" id="42251.A0A2T7A0G3"/>
    <dbReference type="OrthoDB" id="434647at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF177">
        <property type="entry name" value="PROTEIN YOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="335" mass="37423" checksum="8CC2A382118FC523" modified="2018-07-18" version="1">MFDLLAKILCSVATFLFPVFASYKALKANDPSQLTPWLMYWVVIACILVVESWTGWILCWFPFYQEIRAGFMLWLVLPQFQGATRLYVEHVHPTLDAHEREIEEFITRTHDQAKAAGVEYIRKLIDYAREALFGTLQQAHQAAIQSSQQHSQPPEDPTSFVQNLFTRWRVPPITPYAPQMATDFYHFLSSALQQQEQRNPSTGDGMPNSATLIPPGIEGKVEKTRFIELQRERLKVVMAALDQEMSTIRGTGEPVGGTSIASVLDEATGAYPSEKGKFFKSPSSGNMSSAEGDFDHVTMSDAASESSPSTAPTAKWLWAWGKPQPSTPSAEKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1J1</accession>
    <name>A0A2T7A1J1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1J1"/>
    <dbReference type="STRING" id="42251.A0A2T7A1J1"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="212" mass="24024" checksum="59A089E54E9A182D" modified="2018-07-18" version="1">MVSALHELAHRMFARWFEEKLLLMGIREELEATGELTCQVPGGGGQPDSSYKPWPLRALDDDWPTLIIEAGVSQKIADLQEDAIWWLESSREAVSTVILIFASRPEKQLLLQKWEMAEIPNPQRTRGRPWVVEDIVPMSIEDMEIIGGVITGDEAKKKITIDFKKTLLRDPERLNGESDCVFTCEDLRDIARRLWRNTLPSGGQNGRAGVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A352</accession>
    <name>A0A2T7A352_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_969374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A352"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF5">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="12192" checksum="4368ED9A43908F29" modified="2018-07-18" version="1">MPPTATVKVNGTVIAKSDIYETVEGNIYFPPQSVNSEFLEKSDTSSYCPWKGAAAYYNVNVDGVTIKDAAWCYPEPKDKFRPYKDFVAFCLYAPLMLHLKRVPFRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A381</accession>
    <name>A0A2T7A381_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B9Z19DRAFT_969083</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A381"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015575373" description="Vacuolar protein sorting/targeting protein 10" evidence="20">
        <location>
            <begin position="21"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1364"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1411"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="46"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="21">
        <location>
            <begin position="712"/>
            <end position="1352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PUU82196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1478" mass="166362" checksum="A096836179607C2B" modified="2018-07-18" version="1">MLLLRVWALAAVWLATQALAKKSPEVSKTKLDHLPLVFFYFDDSPVILTLDAHANNVWRSGDDGKSWGKVNGVPDGVAWDIIEHPFDKKRAFIFGEGKEHWYTENRGEKWYKFKSEVSPSLIQPPLVFHAKEPEWILYSGRICEDEDDFFGRSCKEVTYYTKDGFDSEMKKLKEGTHGCMFAHSSPVFEGEKDETVLCIVNGDTSYTESRKLLVSKNWFKDSEEPKLDGYKTVNGLAGLAGIQKFIVAAVKTRGTDEMALYVTDDAKTWHRAEFPHDHGGLREDAYTILESTSYSIQVDVLTTKVMNPIGSLFTSNSNGTYFTRNLDHTNRIPDGLVDFEQVANIQGIVLANVVKNADQVLENPLTRKEIQSMISFDDGKWDTWVPLKGPEGKRLNLYSVTALADGGRIYSSPAPGILMGVGSIGDHLAEYKDCDLFYSDDGGLTWEKALTDAHKYEIGGSGSVMVAINDEDSTDKVSYSIDHGKNWEEVKLDERIRARLLTTTPDSTTLKFTLIGTTKDKTAYVFALDFSEVFERKCKLDKGSEDGDYEKWYARLDEEGKPDCLMGHKQYFWRRKPEVNCYVGEDYKDPEPEKEVCECTKHDFECDFNFVRENRKKDDDCVRANGIKLSIPAGECKKNEDTYMGPSGYRKIPGNDCKGGESLEDKVERKCDEVTTTPSNGKVTDVKNSFAGKRVAEYFYLENAESASKSDETIIMRTEEQEVWITRDHGATWDRRLEDVNVVSIYPNAHLWDAVYFITPDAEVWYTLDRGEHIEKMTSVKTKPNRQGLQVIDFHPTKRDWLIWTGQKDCDSPSTCHSVAYYTKDNGEEWHQLLPYVGTCKWIRTEKQQDSEKLIFCEHFETEKGNGEGNVELVASGNFFDDRRVQFGSIIGYATMAEFIIVASINEDGTSLKASASIDGSNFAEAAFPHNFNVPHQTAYTVLDSETHAVFLHVTVNPKKGFEFGSLLKSNSNGTNYVLSLDAVNRNEEGFVDFEKMKTLEGVAIANRVENADKAADGEKKRLRSMITHNDGATWEYISAPKKDADGKDHGICDTSDPKKCSLNLHHYTERVDPRDTFGSGSAVGLMMGVGNIGDALTGLTGYKDGDTYLTRDGGITWKQVKKGQYQWEYGDQGSIIVLVEDNVLTDKVHYSLDEGESWTEYIFAGSSDEKMRVTDISTLPSDTSRRFILWGTREGDGNKFWTVQLDFTGLTDVECDLKDDDGADSDDFEPWSPVHQDGCLFGHRVQYNRKIPTHNCFIGRKIKQPHKILDDCECTRHDYECDFNYQRDTAGVCKLVEGLTPPDHQAVCKENKDQVEYYEPTGYRRLPMTTCKEGDELDKSSKSHPCPGHEKQYEKEHGGVRGFGLFLAIVAPVIAAGAIGWFVWTRVLDGRFGAIRLGEDNNGQSPFVRYPIIVISAIVALAVSIPTILGAIGSWASSKLTRTRRYTSRSSFARGADYSVVNTDEGELLGSDDEDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3C0</accession>
    <name>A0A2T7A3C0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_941243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3C0"/>
    <dbReference type="STRING" id="42251.A0A2T7A3C0"/>
    <dbReference type="OrthoDB" id="5419268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="323" mass="36975" checksum="2D4D80399EDECB29" modified="2018-07-18" version="1" fragment="single">SDIYPPPNHWIYESEEIRALWKYHLKHGKQPDARLKRHPLRLLDESKLKLDIAGDESAIIQDQATGEIVAMVYRNFMPGQYHSILEWINATILSSIGRKKSARLEDPGKIVQTGYSAGSRSHPQFDWAKNLLSKTYSTEEQQEIGYLESSIFALFWNMARKLIHGDISKDIEEFLETGIARMDNKGKQKANNTYTIQHEQEIYEFNQGELAPPVGFFASNYSRAIHKETAPHKYSLFWTTERSLEANQGGNFFISDYGIRIRGAENTLVAWRTRMFHGTSLARLDSIESCTGKGQVGLSIVSPNTLPKIWELYMNEGIDEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3K2</accession>
    <name>A0A2T7A3K2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1061981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3K2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="192" mass="21738" checksum="DEDA147F4AC9B7CF" modified="2018-07-18" version="1">MPPLYTLSVGKAEVEGSIVSPRNSQRFLFLSIRAAHWHTSNLEGVAPSLQYDGTGMYAYTARWPISPHTVPSVCFGIIIIVIIIILRGWKRFGWLVDTGSDDKGVVAGGGFRIDKACYRYRYGTPALTPRYYRSNLHKARGYRRGHGLYPKTQWKPVDPPVIILTIGVRAERMLEQQAPYRYTLQDRDGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3Y7</accession>
    <name>A0A2T7A3Y7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1074916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000028">
        <property type="protein sequence ID" value="PUU82452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3Y7"/>
    <dbReference type="STRING" id="42251.A0A2T7A3Y7"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="249" mass="27600" checksum="5F43E7A0DF1E71C7" modified="2018-07-18" version="1">MSRRYDSRTTIFSPEGRLYQVEYALEAISHAGTALGVLAKDGIVLAAERKVTSKLLEQDTSAEKLYILNDNMICAVAGMTADANILINYARQAAQNYLLTYNEDIPCEQLVRRLCDLKQGYTQHGGLRPFGVSFIYAGYDSQREFQLYQSNPSGNYGGWKATSVGANNASAQSLLKQDYKEDCDLKEACAIAVKVLGKTMDSTTLSNEKIEFATVGKTESGKVYHHLWSAEEIQSLLREHGLAKEETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4D1</accession>
    <name>A0A2T7A4D1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1190260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000025">
        <property type="protein sequence ID" value="PUU82589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4D1"/>
    <dbReference type="STRING" id="42251.A0A2T7A4D1"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="303" mass="34566" checksum="DFC1D64A8D04B894" modified="2018-07-18" version="1">MDSIALRWHSIRGGRGKEDTGWKRFLVFTMLTEKRGRRDYVALFTYFSFKGWARVLFAEGPRVVVNTLTLVSVIRVDLIPDHEAEALSAIGRFFKNVGHLYDHKQVQALIPGTMTFATIFWLFTIIELTIACIMYICYLIRVIEESSLKDYCRKRVDKRMTKIVLENHRQGLRKEDLRQPTLPAMLQQNSRMGNTRNSFTKTPTLNCQPIIPDVWRGQSPHRLNRAETATTIASSTYSQSSTLPPSHVGHYPHYPPLRPQHSTHSSYDSVAALTSAPVESPYSDPAYPSPTHHFPRGRSPIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4Z2</accession>
    <name>A0A2T7A4Z2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1040242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4Z2"/>
    <dbReference type="STRING" id="42251.A0A2T7A4Z2"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015785414" description="protein disulfide-isomerase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="8"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="134"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU82811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="371" mass="40520" checksum="D82824A9C9F699DC" modified="2018-07-18" version="1">MKGLGSLFTLASLLLVATASNVIDLTPDNFDKEILKSGKPALVEFFAPWCGHCKTLAPVYEELADSLASQKDKVTIAKVDADNHKSLGKRFGVSGFPTLKWFDGKSADPIPYESGRDLEALQAFVKEKVSGLKLKAKREAPSNVIVLSDANFDKIVHDEKKDILVEFYAPWCGHCKNLAPIYEKLAKNFASESNIVIAKLDADSPGGKASAERYGISGFPTLKWFPKGSAAKEPIPYESARSEEALTQFINKHAGTHRAVGGGVDDAAGRIASLDTIVQKLISGEKDAEKELAKAAEQVKEKYAAYYLKAADKLSKNANYAKKEIKRLQGIAAKGGLAPEKLDDILSRKNILTQFLSEEKEEEKEETKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A651</accession>
    <name>A0A2T7A651_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_965524</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A651"/>
    <dbReference type="STRING" id="42251.A0A2T7A651"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="93"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU83155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="59739" checksum="4E23CB34428B4404" modified="2018-07-18" version="1">MRHPPPLTVRRLLITQSRLRQISSFRPIAHVSWSRPSHAFSQSRPHPADTTNPPSSSKPGHTSGSPPDHRLLAAAQDLLITHPVSPGSPLFLPHGSRIFNKLTSFIRSQYALYGYEEVITPTIYKKSLWETSGHWENYKGHMFKVTGRETEETEKQIAIGEQEKIEAEEEFGLKPMNCPGHCLLFKHAAGKLSLRDLPVRYADFSPLHRNENSGSLSGLTRVRRFHQDDAHIFCRPSQISQEISSTLQFIDSVYKVFHLPSYKLMLSTRPKQGYIGSLEEWNRAEAALKASLEESGQEWAINEGDGAFYGPKIDIILTDSDGKEHQTATIQLDFQLPQRFGLTYFAPAPVAEQQGILSTDPEELKESGFVTPVIIHRAILGSLERFLALLIEHYNGKWPFWLSPRQAIVIPVAMTDEIVRYARNVRKVVSGLPGETGRINANSPLAMSRRTFNVDIDESGGLFSRKVRAAKTKHYNYIIVVGEKNLNAKTVSLGPAFSQGQEHGDAGGVGRSLDMSMEEVYQRFVELENEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6S6</accession>
    <name>A0A2T7A6S6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000012">
        <property type="protein sequence ID" value="PUU83447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6S6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="359" mass="37660" checksum="EB3C877683270C2C" modified="2018-07-18" version="1">MAKRGSSSFSATKVAKTGMVIGKLVEKLLAMEKEIGRLRHHVSVLSRRNHVLSGGKKKVTERKGKEEVAESMAGAGVADCGVADPEVVAHDEAAVAKVVEAADLGRVAERMAEGVAHGLSCGVGEVGVEWEVASVRESISNSIAMDSEQESSVFEEEEDMVVGGKIVVRMPGDRKRRVLDSGNRSVDSGGSGPLVVPLGPMSYGRGLGVLGDSGGHPLQMAQVIPRGPRLGDRAASGLSAGSVRTNPNLMGVSGGSDGRRQSPVVGGVSFSLPPVALYAEVWPEHDISSRTCDEQSKTRVDVWERIFGWTGRGTRKGDGGLGWCISTILHLMAGERKALPLIVLCGARENGRGLDPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A721</accession>
    <name>A0A2T7A721_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1098600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000010">
        <property type="protein sequence ID" value="PUU83538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A721"/>
    <dbReference type="STRING" id="42251.A0A2T7A721"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15348" checksum="D84BAD171F32EB2B" modified="2018-07-18" version="1">MSLVVYGASGLDPAACAWVGSLRYASGFLGMLQGCFGIGGTVAPLIANGMVQRGIPYYQYYYIPFALSILGGIAFMLSFWDESGAKYTRDTSGLHKTGLDHTKEILKNKVFLSDYTPKTSLLTGGDFLDSSGIRVPRLGCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A722</accession>
    <name>A0A2T7A722_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_963682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A722"/>
    <dbReference type="STRING" id="42251.A0A2T7A722"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="953"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="883"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="969"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="53"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="828"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="926"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="969"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="116891" checksum="D0EEDBE01F81491F" modified="2018-07-18" version="1">MTLKEQSTIIDRLQKENFDLKIKVFYLNDKLEKQSDEGVKEMMKESVDMKVKLAEGMRERKSLKRRIKELEKKIQEMGGEKEGKEDGEDNITELWELKERVERYEVEIEELSRREKEREDRMREEISRGGAVGGERAEEVGMLREFLETETARREKVDMENRRLREEIWRMKNESSGQPYLNSHHSISTRHSSTRSVSERDRDESRERGLMNQLRVENDELRREVGAQTSMLTSRNREKDRLYQEIEDLKLHLRNGGGSALGMVAEHDQHQQHQNRAASVISDRILDRSVSRAGGAASVAGTHVSMLSESEREDFENANGQLRDRISELRLKNQELQIQIENCYREIDQKTEDMERVVAEYEEELQLAHAEVQEMQAERNDALRMREEIEMDFDQLKEEAEEEIQKLEEELDIRLGDIAKLGEDVRCKEEDFKGLQQEMRNVSDIVVRLEDVHEGHVGEVRRLEGKIEDLQRTLRENEQEMSVLEGSLREANEKIERMTVQSESAKGEIAFLREEQDADKIKIGELETVIKGLEETIEEEREKVADARERLESERKDREKMGDKRQQEWERKVNEKSQEVMNAKDEVRRLRSKVSNREEEAKQWRERLEELERALREALGDLSGTRTGLFKSIVNLQSELESTLEELDCTRSELVEKDRVLKDRENLLEGMALESRKLTDLLDKERAGRKSDRAALETLKTTHHHTRHTITQHQTQYTELEKTRNKESKSIHQLEQQYREQLAERNNLLTQIWLRLSALCGPDWTHRNSLVSTNTNNVNGKQSMEAAVVGALPGFQKNMLIAVKTIESIVAGFKTRCRGVERDLWKEYQVVENALESRTRRLERLENLVRGGIGEQNGMRTEVAKLRTENRLLRAELNVVKNEASSATTTTTTTAVSASQQTSPALHRSKTSPAVPQQPSKEKETSAPTSTIITRTSSAASAPTDPQDVSEKRWILRLRELEKRLKAEREARLLDRSAAKKKVEEARGASAEYKAELERERAVSGSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A775</accession>
    <name>A0A2T7A775_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A775"/>
    <dbReference type="STRING" id="42251.A0A2T7A775"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="256" mass="28571" checksum="77614E059C738653" modified="2018-07-18" version="1">MPQMMRESKSAGGFFIEPKRSPFAGNLHHMLFTRNHRLGLYTYSALPLRPLIPNNRPPGRALLMPHTLHYHAADLHRRFSSHLSPPAGEFPLSEETTLGPQTSFQDLAFTHTQVIEGEKDTLFSIEIHAAAAQLPGPPAKRLDAARAYADAIVISRADVFYVGDYLVRLNCGGGRVIFVDDSLIQGTPRVVFMEAILAESKAFMGIWALNSPIDWMLTAPTADLGSTLAFLCFERHFRSNCRRCFAKYFLGAVYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7J3</accession>
    <name>A0A2T7A7J3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1071960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7J3"/>
    <dbReference type="STRING" id="42251.A0A2T7A7J3"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="65"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="23667" checksum="6797636C1BEFE58A" modified="2018-07-18" version="1">MSDSGEVEVAPANYSVLPREVTDEIGSTKLFNKWSYEDVEIRDISLTDYMNIRTPVYLSHSAGRYAVKRFRKAQCPIIERLTNSLMMNGRNNGKKLMAVRIVDHAFSIIHLTTDQNPIQVAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQAIALLTIGAREASFRNVKSIAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7M8</accession>
    <name>A0A2T7A7M8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1105048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7M8"/>
    <dbReference type="OrthoDB" id="5389357at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="269" mass="29542" checksum="58654A7A207481C7" modified="2018-07-18" version="1">MAIRAATLSRPSTSHSSKPTPTPGISRSGTAYSLTPRSTSNSSSGGSSGGGGGGLSASATFTYHAPTAIIPSAYEPPQTTAPATAQKAAKSIAAVEDTKPDKSRRFLSTKLWFSNSHYDGENTIFSFSSSNSTWGTLFNSLTLGLSAPLCRVYFVELLFEGRRVEGKEEVRAFLEGLRFVQRGQQTSGEELIRWLERQVVYERRRFGFEKLQGNSFAVYLLTMPRLGGSEPDTYPLRKIAEQRYRVLDCVDNIVMLGGRFHNSVWSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7P9</accession>
    <name>A0A2T7A7P9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1098551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7P9"/>
    <dbReference type="STRING" id="42251.A0A2T7A7P9"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="89"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="197"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="225"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU83732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="357" mass="38860" checksum="DD959F4D9584476F" modified="2018-07-18" version="1">MVAGGIGGSTGDILMHSLDTVKTRQQGAPTAIKYSTMSDAYVTIFREEGFRRGLYSGVTPAFMGSLPGTVIFFGVYEFSKRNLIDAGCPENLAYLSGGFLADLFASVVYVPSEVLKTRLQLQGRYNNPYFKSGYNYRGTLDATRTIIRREGPAALFYGYKATIMRDLPFSALQFAFYEQFQKAAKSYCGSRDIGLPLEIATAGFAGGLAGVITCPLDVVKTRIQTQVRTSPSAPKAATTPASNVRKESRPFTTLQPSPPPPATPAPSTPLPQHRSISTSSPSTTSPPKTGPLKFNTSSVFEGLRLLYRTEGIRGWFRGVGPRAVWTSVQSGTMLVLYQYLLKQLEHWSEAQSEGNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7S3</accession>
    <name>A0A2T7A7S3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1071615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7S3"/>
    <dbReference type="STRING" id="42251.A0A2T7A7S3"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="488"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU83773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="866" mass="92254" checksum="F950C80103C7EC36" modified="2018-07-18" version="1" fragment="single">MFSVAQNAATTLGNTIANANTANSASGIRSRSGTGSSEPGRGEAGGEIAQQGGGSGVEGEKSEPQKRPAVETLGQGELSLGSLGILPNSQKSSASPSEGRPSRSASVNSHGANSETGDSRAIAGSGGAALQTGVSTVPIHRAGFVDGGLSDEALQSLDSAVEATGESTFNSPAGPSGPYALENLRKTPMAEDSAFIGRDSDYTPEKGPPNPVEDRDDTWSGDADQRRSGSVRSGGRRKRGSSAASGANPQPVPKPTGFAVAPKRRNREFHEMFRSVPEDDYLIEDYGCALQKEILLQGRLYVSEGHICFYSNIFGWVNTLIISFDEIVSVEKKNTAMLFPNAIVIQTLHARNVFASFISRDSTYDLIVGIWKIGHPQLVAGATGVRLEEGGDAEGGDQADGTSEYEEDGDDDEYEDASNDDLGESYTDAGEIVLSDDKGKNAGGAFKSVSRKVSQAVLGASGGDGNGAVVDYPGPQTHPPTSCNDDHYDRPLCDDIIPAPLGKVYSLVFGPASFPFMSRFLTDEEKVLELSIPDKGEWIEGPDGKKTRSFSYIKPLGGGIGPKQTKCNITETLDNCDLEENVIVTATTQTPDVPSGNMFMVKTRYCLTWADDGQTKLVATCTVEWSGKSWLKGPIEKGANDGQIAYNKNLRVALKKEVEPKESIGKQAKNKSKKRKKDLNAKSEAISGAAGGTIKSREAQAAGFESSAGQDGWGVFAPLKTYLGPVADIISPLIGGAPGLVAICLVLTVFFWWQSRSAYSRHANTAVGGGPGVHHSHQYWDTLWRSEEDGLWEWLEDRVGINEVVAPPSPRANSFERAARSRRDAGAGLTQGMKRREVEDAIGVMEERLAILRKVVQEEKYDDVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A889</accession>
    <name>A0A2T7A889_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A889"/>
    <dbReference type="OrthoDB" id="5378679at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="406" mass="44501" checksum="C8CF356768D45E6F" modified="2018-07-18" version="1">MATSSQLPSSYQTAYSPTDSFTSPPLSQVQCGAKIVFLGAPTRSAILHAKSPRLLKDTELLDAFRDRNSNGTDGDVVPTPTIITSATSEHAAWRILPLKRKRLPTGFSQQPDLPTPIIPPAELGDETSSTEYSSSSTAPASTGSEDLTHSFAVHNIPSSPVHISTTASINTSTITTTDGSFASFTSDAALNSCIPALPPIGMLTDLRSLPNARYLTSIQPQTMSISTIVGIISISPVRNIVTRKFHKPLTFQTLLVGDETAAGFKIDIWIPLTTTTPASRAFKETVDSLRLQDIILIENLALGVWNNKVNGATLRKDRTHIKLVYRLNRFGSRERRKWGNVNLQSGGEDLGLEKIRRVAEWAENFVDPGRARRNKKPREGTRNTEGENVLEDYEEEETQLPDDTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9D1</accession>
    <name>A0A2T7A9D1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Kinesin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1070149</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A9D1"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="5"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1581"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1374"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1681"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="712"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1483"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1681"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1692"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU84346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1702" mass="191703" checksum="F4FD118BC867B0ED" modified="2018-07-18" version="1">MTGGNIKVVVRVRPFNSREKDRGAKCIVQMKDSQTVLTPPPGAEKSAGSKAAKDGGPKVFNFDRSYWSFSKSDPSYAGQENLFDDLGRPLLDNAFQGYNNCIFAYGQTGSGKSYSMMGYGEEYGVIPKICQHMFERITTQQTDPNLKCTVEVSYLEIYNERVRDLLNPSTKGNLKVREHPSLGPYVEDLAKLVVSSFSEIEHLMDEGNKARTVAATNMNETSSRSHAVFTLILSQKRHDVETGFDTEKVSRISLVDLAGSERATSTGATGARLKEGAEINRSLSTLGRVIAALADLSSGKKKNANMVPYRDSILTWLLKDSLGGNSMTAMIAAISPADINFDETLSTLRYADSAKRIKNHAVVNEDPNARMIRELKEELQQLRQKLSGGGSMPEENYAPDTPLEKQIVTITTPDGQVKKVSKAEIAEQLNASEKLLGDLNQTWEERLEKTQQIHKEREAALEELGISIEKGFVGLSTPKKIPHLVNLSDDPLLAECLVYNIKSGTTSVGNVETSTTAQIRLNGSKILTDHCRFENENGVVTLIPNQKAAVMVNGLRIDGPRRLRTGYRIILGDFHIFRFNHPQEARAERDKLRQSATMNSDHRHSLSNGITIDVLERAESETNGSRPDSPAMVPASRDIDWSFAQREAEEMRHRNVRRGRPDSRLDSIDDETESVMSFPGIREKYASIATLDELSLDTVITMPGTPQQGETEERLRLIKDEMQAQLEKQKEEYQQKLKATQEAHVEIEEIKAERVKMQEKLELAKKEMQEKLELQRKEYESRLEEISLSPKIRDPEDGLTDVEKKLARFAFDHWRKRRYVRMAESILQHAAILKEAQIMSNEMEKSVVFQFTIVDEGHTFQSSYDLVLNGVSAEDDEFLDMARKPCVGVRVMDFETNVVHLWSLEKLQNRVGQMRQIYQYLDRPEYLQHLRPRDPFSEPTPQQYSLIGDVDVPLTAIFESRSQDFVLDVISPHTASVVGIIKLALEPSSAEAPSSTLKFNVVMRELQGFAEREGTSVHAQMFIPGISDESGATTTGMIADFDEGPVKFGSTHPMSMPLGAPLRNTALRVAIFAKITSMHLEKLISWDDMRDHKPTSPQKKRNARLNETEFYTEEKHDVFARVQILELSESGDYLPVEVIQQSETDPGLFQLRQGLQRRVQLNLTHNSGDAFQWSDISQLRISQVRLLDPRGKTPDMSSPTREIKLNTVLGPVVKKNPDGTGTIGVVAQWDSSLHNSIYLDRTTADKYRVQMNLRWNVVSDKLSEPIAFSQDVFSQVQPRVLKSPNKFMQLWNNNRITHASVGLFQLVVRPAAARRAGDLWRMNTMHRYVKGEEYLGEWTPRGVSLVRDFLRAKRRRIRAAEVENAKGFLSSLPVTRNVTPKPGAGEPLAEMPREGPREVPPQEGFYGEAMEPSEERGEEVGAEPELTDNTKITEIIQEPPSTEEVRDENGTPEDSPDWAPDWAPEYPPAVTPTGSSGGNSEGSPRESRQRSPERSLTKTPEGASVEGSITGESAALGEEDPHIHVLRRYVDLWSSWKDPSENILVRQNTEPPQDAACFAEPTEAEPPRLIAEVRQIPKSTSVLKSGYLFMPDESNKAWIKRYFELRRPYLHVHSITDGEEITAINLTHCHIDHNPHVRKLLRKQNNNIFAVYTPLNTYLFGAKSEREMIEWILKIDQSHFDTNTSRSNTPADEERRVPSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9G6</accession>
    <name>A0A2T7A9G6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1111913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9G6"/>
    <dbReference type="STRING" id="42251.A0A2T7A9G6"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU84342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="510" mass="56351" checksum="4BBEC7EE3DF65B8B" modified="2018-07-18" version="1">MSDNQALLLKISEVAGKINRHKNQTEQSAAPAYGGSHFPQRASPYPTNQPPRGRGGWIPPHHHQHYHPRGVAPRRSRGRASWPSPPVAHHHKTLVINNNKAADGSAATPTTNTFASTSYVENIPPNPPGQILPQRNDSTTQSAEGWVAKRDRHMQLINTAVYDQHAQARARDLEKTRQTQLMRKEEREKQKLRGYLDRSRNTASQVPFEVLVQGERYKVAAGGSKLIKISGEEQNKLGLDRKRGVCLTGSRLQTDGPQNTKSTPKKAVVGGVNFVRSKNGNLWRVGLVKASHKPRHIKKPCKYYSNTGKCKNGMSCLYTHDPNKVAICPRFIQANSCPEGDSCDLSHSPSPHCMPTCVHFLRGNCSNDKCPFAHVKVNPAAPICRPFATLGYCDKGTECTERHVRECPDFDEKGVCTDKTCKLQHVERAGRRRVAAAQAAAAAAKAQGSGNDYNTNSDSDISSDDGEAIDSDDVDSDTLSEYDYIRRDNQGSEDIGEITMQEDFIHLPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9H8</accession>
    <name>A0A2T7A9H8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9H8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7560" checksum="EA25AD6927BFF715" modified="2018-07-18" version="1">MRVDGEFSAMVMTMMTEVVGGGIFCWGIWELGFVGLVLVLVPVVSGAGRRTEMGMWVLRACGGRGGMRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9R2</accession>
    <name>A0A2T6Z9R2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000649">
        <property type="protein sequence ID" value="PUU72223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9R2"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9R2"/>
    <dbReference type="OrthoDB" id="5369347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="321" mass="36597" checksum="306F27A4CE8BDB82" modified="2018-07-18" version="1">MFLLLDAKDLKLITKAESIKVSGEKFWNLLSNDINIGQLDSTYQYMDIGQEICSQEKNRVLLFKRCCTDNSIQQLRQDFKGLKTAAYTWALNGLSANKTVEYSKISTPYQQGLIYSQSYSPLKCLFDAAGCYPLQNSSLEYLSLTPELIKSWQASGPSGRGISLDIDKLKTAYIHSRDRILSSLQGAMKRKMSFGVRQEHRLSADLFHQLASSEDRIQVSLISSSIWSLDNLEIFHYLETNFLRFGLGLEYTFHCLQVTIGGKTKELSKLFRLFLHLQKASYSNFLLESIGDIWRTDPMPNSKINYPGLGISKQFHLFNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAN3</accession>
    <name>A0A2T6ZAN3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1069668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000506">
        <property type="protein sequence ID" value="PUU72557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAN3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="214" mass="24636" checksum="6D99C4A490B4EFCD" modified="2018-07-18" version="1">MSAIPSLAGKKRGGGQTMKQEADRISWHLKEIRGLRSGNKERDGRIENLRFDLRERDEELKLLKEKYAAKEKELEDERVAAKEREKVWKEKEALLTTAVIFKAAFRKAGRRKDNRMMPGDRIQTIVGFQEEPDRFGCETPAQADELSSVWGGVMKGRNAIAHHEVTGEDVIEALNHCPDNVRPVLKRKFQYLFDTSPEDWPTADPEKKKRSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAU1</accession>
    <name>A0A2T6ZAU1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1008964</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000496">
        <property type="protein sequence ID" value="PUU72608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAU1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAU1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="60" mass="7075" checksum="E3885489666B439D" modified="2018-07-18" version="1" fragment="single">LSKMDGMGGWEGWRWILIIKGLLPVVVAIWAFFIVLDTPERAKFLTKDEKEFLLRRLEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB00</accession>
    <name>A0A2T6ZB00_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1137012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000486">
        <property type="protein sequence ID" value="PUU72677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB00"/>
    <dbReference type="OrthoDB" id="5471005at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="19481" checksum="CE9DCC7CEE79BAAE" modified="2018-07-18" version="1">MATNFLKLFVRPQVIARMRTIRSFKHQQANRSLLTTDSAPNSAPQPRNRRRGESCTFKARLWDHVYENDRRIAGLGDKFNDREITMHQTLSNLSTRVDTGFAELKTLIASQHAKMEGSVTLITWKIGILGAGFLFVLGFAGPQKTNFTEYVLQFLKTSSSEPTTDNGMENKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBA3</accession>
    <name>A0A2T6ZBA3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_621895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000467">
        <property type="protein sequence ID" value="PUU72778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBA3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBA3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="128"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="443"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1219" mass="138384" checksum="79F93A6290778CA3" modified="2018-07-18" version="1">MEIYIQNIPYSSGRDSELRRTLEPPLNELGVLAFRATVFKGRPRHGGTKTGTLTIPTQEAGNKFLSSYGPQRRGAPRTIKMQGHILRFAISKQPYDHHIVKSLQKEQENLIKETLQQPRIQRTRPPGKKFDIEKVECGVWSTEAEERAPVFDCYYSIDVVGTLRFGGRAVHAVFKSDCDPSQDGELSHIFEGLGLDMLNDNSADKSIVARYIDMTSIVVSKGDTKSVTFTLDKAPRFYNEAPQQDELLFGFWGRNVRKRVSSLGADHALYAPFAFVYRIYLEEAHDIDSVMLLGEHRGIPPVVEKRTAMRSAALEFQESSKELVGRLGRNFVGPGMFPIAFQLNRIWANGHLPPSSVLRLLPQINSFVREYGCEQTATILQEFVGFLTREDPTNEPGTHSHQALISELSEWAASVLGRSGSLIDSILERAQKKHMSPIHHVSITPAGCYFYGPSSEPQNRVLRKYPDHHEYFIRVTFYEEDGEQLLFQHNVDQSPIYNNQFRLYLSEGVTIAGRKYEFLGFSSSSLRTQSCWFMAPFYLDGEYLNPKIVTSRLGDFSRITCPGRYAARVGQAFSDTYGSIDVRAEHEVEIPDVERNGRTFSDGVGTISQQLLNRVWGESESLRKTRPTVFQIRFAGAKGVVSLDTRLVGDKFCLRPSMIKFRGSSDRRIEICHSANWLPMYLNRPLIKVLEDIGVAESTFMTLQKDAIEELRQSTTSVAYAANFLRRQRITSRAIRLPWVIESLKNLGFNFRDDHFLEQAFELSLITSLRSLKHKARIPVKKGMTLIGVMDETGYLQEGQIYVTVQSQGQSAFESIDGTVLITRSPVHHPGDVQMALAIGTNRLPQDSPLRALRNCVVFSQRGTRDMPSMLSGGDLDGDLYNIIYDTRFILKTKYAPAEYPRVSPKDLGRPVETSDIVDFFLEFMENNLLGMISTRHLITADKKAEGVHHPDCLKLAELASTAVDFPKTGRKVSKSEFPKATHCRPDFMAPGPRILIKKEPEFAEENAVPDDDDDDEDTPTVYYESEKVLGKLYREIDETAFLREVQGTVHRERRARNVDEGALIRGVWEWLEEAIPNYTWEDCIDDAAELKEAYERNVKQMMINYSDMPWKYPLREVEVFIGNIVGKERQTQRQKEASLEMKDEFDRLASSIVESMQSESREKTLGIGMASLSLCLPEKNWKDLDSLKSFAWVAISVLLTEVDKMQKEAKSRGGRMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBJ2</accession>
    <name>A0A2T6ZBJ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1136520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000452">
        <property type="protein sequence ID" value="PUU72861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBJ2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="224" mass="24906" checksum="1FBACC5AAE1B7B64" modified="2018-07-18" version="1">MLGHPHEGMPEGSVPTEISSSSSEGKRIIIPQAPSSSFDSLEALPSALADTCPPPLACPVSGCLLVLKGEMPHRYLKRHPKYPGLHGRMGDEREAWLNLHKMEHEKFLAALGSTPSHNTSPKEVPEVGQANYADKIKLVEDDKAEEERESRAAEFELRAKNMGITEMKFVAQKVAIWEGMWVAKQNGDDIGGLVVKYGYKKIRTATQWQPHYHYKFITPTTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBY2</accession>
    <name>A0A2T6ZBY2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1069318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBY2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBY2"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="214"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="916"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="939"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1025" mass="115034" checksum="626D43BDE3049ADF" modified="2018-07-18" version="1">MAEHNNSDDADAAFLNALKAEQEMVEARQKASELREESEPIGDEPGERAEQGDTFRELSDQVEEDNHLQSNESKDTSTAASGAASLLPGVAVASPDDGPSSVNGSAVGDSAAQPLLNANMGAGPNTQESSAIPSPSVTPVGALVPDENNNDSVPHTLSVTSPTVGSNNNDSLLVSSATPAPVNAPSAAVPVQSPVQKGNSNVANKRKRLPQDIVGQLEDRIAEDPRGDIDAWLALIEEHRKKGKFDDVRAVYERFFVVFPAAADQWISYVKMELANNELQHVERIFQRSLFNVPNVELWSMYLDYIRRRNNLTTDTGGKARAVVNQSYEFVLNNVGCDREAGRIWTEYIQFVKSAPGNVGGSGWQDQQKMDSLRKVYQKAVTMPVQGVEQLWREYDQFEQGLNKLTARKFLQERSPMFMTARGCLIELSNITKGLRRDTLPRLPPAPGYEGYEDYTKQVELWKKWIQWEKGDPLVLAKEDPASLSTRIIYVFKQALMALRFWPEIWFDAAEWCFANGMDDQGVDFLNQGMAANPESCLLHFKYAERLEATTVIEGGEEALIRKGQLVRKPYDDLLNMLYEQVQKIQRKEKEELARIEDAFEFTNPRNAQDDDEDDDPTTAATRAAKDTQVAALKEGTKAQLQVMTKTISAVWINLMRAMRRVQGHGKVNEALGGSRQIFADARRRGKINSDVYVASALIEYHCYKDPAALKIFERGMRLFPEDENFALEYLKHLVAINDITNARAVFETFVGRVAAEKARKVYEFFYDYEAHYGELGQVYKMEKRMSELYPTDPYISRFSSRYAYKAVDPCSFLAVVSPAQQCKPKSQAISSSAPDHLPRDSRDYRDHPQAPPTAPANGRTSSPKRPANEELSDSSEHQRPRKLHRPDSPLKGAAGRRLDQQKRAQQQQQQQMMQGRDRNIPDRDDGMHRGGLGRGGYQQNPRQPQHQPQQMQMHQPPAPAQLPDLIMYLLSILPGADKYQAARFRPEAMVGLLGNINLPRDVQANNRESTSHHRSAPQGPKRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC00</accession>
    <name>A0A2T6ZC00_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1096160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000437">
        <property type="protein sequence ID" value="PUU72966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC00"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="17634" checksum="BB666C96F06D6A61" modified="2018-07-18" version="1">MSSSNSKKTPGPKQKSPFATKSSQKPGSVQKQQSLLSFFTKAVESPVPANKKGDSDLPDLSSDPVGPSSPANQEDTPTNKHRGRRDVLQVTPSSPSIRALSKRVSYTELCDDDDDVPVLKRGIKRTIRDDDDDLEFLPQDNLIEGSDDGEDDCELYRGTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC30</accession>
    <name>A0A2T6ZC30_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1069283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000419">
        <property type="protein sequence ID" value="PUU73051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC30"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC30"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="249" mass="28115" checksum="3E8BBCC39D842452" modified="2018-07-18" version="1">MAPFNRSAWHDTHIYGSDNRDKLLGGLWAGGGITNEALYFMTEVVCCITDTFTLHDKNDELIERDASGLEPGTYYITTNGKVTVTQDVAHCRAGSRPTGPRCGSFRKAVRMRDKRCIATLRPVILANMNWWSGFEAAHVIPLAFQAQWDIGNFGSHITIPPPNPAHGTINSVQNGILLTREMHYAFDNYSWSINPDDNHKIVCFTPDLSYYGIAGRNLDQTFLDNPSRPPDELFRWHFRQAVLRNMKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCH6</accession>
    <name>A0A2T6ZCH6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1095638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000406">
        <property type="protein sequence ID" value="PUU73183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCH6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCH6"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="218"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU73183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="328" mass="35865" checksum="8FDDF122EC49016B" modified="2018-07-18" version="1">MKIKTAPQPPPISHAHHAPPAHIRTLHKAHQKSPLTVPTVLDFENLPPNSSSSFPITTTSTISASIASAAFSAFSDGNENTTSVESDIPIYKVASVPGLLVIPNLIPPSVQKTLLRKLLSRDLSDPRHKTNLHAHYHLPPLPLGIGSYFELPPETTFRALDANGRDLSVGRMLDKKLRWVTLGGQYDWSLKKYPADSSSLPEFPPDIRELVSSLFGITAQAAIVNIYSPGDTLAPHRDISESSSAPLVSVSLGCEALFIAGVGDEEGVVVRVRSGDAVVMSGEARWAWHSVPTIANGTCPEWLQEWPEERMGWMRGKRVNLNVRQMWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCH9</accession>
    <name>A0A2T6ZCH9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000403">
        <property type="protein sequence ID" value="PUU73198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCH9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="453" mass="47759" checksum="2852458C5B9724DF" modified="2018-07-18" version="1">MNEKGNYLATYAVATDVASAKGRDDRLATTQLSEKPLTLPPHPPPIPAKDGFRPSVPPHSSRVPAEDIDKLTSSKPLPIHCKLSPSPSQSVPLPQPSSPCSPPTQSPTGMNNSQAKTARKSAHISANRGDGHTSSGNVSRRTSIHQGPKPLMDGGGSASPGENNSASSTNGLGILARSSASIASVIVSILVHIATYNPKLTLSHSFYLIDPNHTTQSMFTLETIASECVTVGPAEHVLLLTKDPPILIRESSLESLLKAGRRKTATPKAAAIAQEPRMNVDGTTRKNPRKHQTDKPEERKAKRKRKTPVEGMGKFVALPNPRVNSNARSKLSHPNPRSAPVSGQPAERNTSFSTPLIPTEVHQPQPRGPYVGQISQSPVTPHKKPVDTISISSSSPMSPATSRNPITLSPGSSHGASGPGGDHRSSAECSIDGSESAGYSPSSGSDEGEIFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCJ6</accession>
    <name>A0A2T6ZCJ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PhoD-like phosphatase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1197085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000405">
        <property type="protein sequence ID" value="PUU73189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCJ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCJ6"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="276"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="587" mass="66293" checksum="E495C9DAE2C210EB" modified="2018-07-18" version="1">MDSVPVLTALCALSSSIIRVGSYVFLRWIPGHIFPTIIFTAYGIYAPLFAILYLGKPSYDVIASSSEISISQPADEDAETTSEQALEKPTAIEATETTVYQKRQPHPLKHLLWGTPSISRKLSLATFAINTLLAAATWDLTFRTTYFYPSKDLSFARVGHVGPDSAKLLLREPDSSRYPLSVWYSHDKIPTIDLHLVDTIPTPPEETDFTKTLTLHHLTPETRYRWYTSSNHSGTFTTAPRKDEAPRGGRFTFLTTSCIKANFPYDLTSHPLAVKGFRDLSGWVERLEARFMLFLGDFIYIDVPRRPGFDKESYRQQYRQIYASPDWPSAGANLPWIHVIDDHEIANDWSSNTTGVYPAAIDPFNIYQHSVNPPPVRPAGDPYYTFDYGSAASFFMLDTRTYRSPVHLPDGPEKTMLGARQKADLLRWLSQGSGWKIIASSVPFTKNWRVNGRDTWLGYLHERQELLEQMWKVGGGRVVILSGDRHEFAATAFPPPPDSGYSIASAVHEFSCSPLNQFYLPIRTYKQLDNEDVLIKYVPDGNRKFGAITVDTTNEAQGILKYRLVVDGDEKWSWVLTAPRAAEGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCK2</accession>
    <name>A0A2T6ZCK2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_571503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000409">
        <property type="protein sequence ID" value="PUU73144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCK2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCK2"/>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="969" mass="106006" checksum="E025BDDC17045CB3" modified="2018-07-18" version="1">MADLVDPLSALLPHSASPSFLECLHDEDVDGRLDTDEDLEFIEEGEQEDEEDAKPSVFNQSSDGKDKERERISPGQDSRQNGDGENKENERERNTANGKIGDLENSDRGARHGRDVQVLPEANNSKPATKRAPLTLVELPVDVLKEIVKEVNHTNDLTNLSLTCRCLHALSIPHIYSRFDIVWPDASTPGDRTGVDALTYGLATLTASGRRGNDYARWVKKFSLGNGPSDWVGEYNINKEGGKMLGTLVCLAITRMIALETFSWDMPTGVLRDVFKALHDLNGTLKNVHVRFHDNTETTPPTSQDPSRRVETPTFKGFEGLRSLSVLDIDEMQYLEEISYAVEKSVDKLRELRLGLAHHVTPGGRWIRDLDEAPHGEASPLVQSAVGGALGIVVSRIVDLEEGRRRRKINKLPENANTHAGQNIPPPPALPQPPSSTSALVTLVNGVPAPANSGLQGGAGSNLIPTDDAPPTPADGASTTDPSLDGFVEVESAAPGAATAGTAHATASVDGTAFNIVGPGAVQQTVPTLSSTPITIPQVPSPVPPTSQGPEPVFSNESPVTPTPTVGPSAPKPRPMKPVETEEEKPVVQLTLETLELERVPLSIRVLTRAIDWTTLSNLTILGCHDHDRFWRALRHRFSPHPNHGSSMASTNLSINKPGYLRRPSNPVGCALEYRIRLKKLHTDTVTGALLAFIRETLPPNSLEVLFLQEIPSYSSVVSMEFIYKSAIRRHKGSLKKLLIDSNVGLGGENASKWIFDKEVLAFISSGKMPNLRELGMAIEWKNWHYFLTRLPLMPQLRSLYIHYVRGGPHISDFESKEMAQQIVNTVILRPEVELCYVGVLNKCFELLEDGGPDDPETEPDIHSATAQHAPPGATGVPGSPAIGMTVVPIAINSEDEDSDAEEEDEEEDEEDEEDGDETDTDEVVGDKYLSDDEDWTGKSTDKGVRVRLREILFYDDKVAVFRARHGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCV8</accession>
    <name>A0A2T6ZCV8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transglutaminase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1135398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000389">
        <property type="protein sequence ID" value="PUU73309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCV8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCV8"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF5">
        <property type="entry name" value="TRANSGLUTAMINASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="2">
        <location>
            <begin position="293"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="772" mass="85135" checksum="5C2B24C95A5F885D" modified="2018-07-18" version="1">MVDPPPVESTGGGGSIRERMAMLQLNQVGRNALTRPAPPPLPPKRVPPPLPARKTSRSSLASCYSSSSGSDRGSITSVGSNYSGRSLPPVYTGKESPPVQFAEKSKAHDMPKKNPSSLPTRSKTAPVLPPRGPPLPSRTYTSPAQNQEQPQRIPRRLPPPPSISVPPLPNRPKLPLGSHTEPVISRTPPPVPRSTRPPPVPLSTRPAPSYRLSSTMPCLVCYDFSGPDKHASLPQFERIRVESLQQLAVGLTTPFSDTLDKARVIFTWLHHNVSYDVHGFLHGKIASQDPEGVLQSGAAVCAGYAGLFNKLATHAGLESEVVSGHGKGYGFNSGEPYKMNHAWNAIKMDWGWHLIDCCWGSGSINGPPNPGYNKRLAPEHFINPPMSLAEVISLGIQQGVEPLRYSSFGEEFGFSEKAVQPPVNNIDTFAGRRTVFSLGLPCEHMSRKEEWVLFLSIGEFSDKNWILMNSDGRGRYHVEVEMPNQRGLKVGLYRAATWKGNDAKGLSAKEWQAEHIESGSLIRYNTSPKHRRVRIFIIERPHVWTGIEKRLAGRVMSISVGASEDDISKYLRLRLDEDKILDAMDERPEAEILKKIPETMSEIAILRESTISRRREKLSKMMDGLGLEDVYGTTIERMKVRGGGTPEWCSIVCVSRLGLGMTPMWISHEERPLQADELYHALAVELGSTDFDVGNISSIPTLLSCCQALVTVDKEALTVPLIHFTLQEYLSSHPDIFSRPHSAMAAGFIYDNYKIAPSRVSLRPLISPTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD09</accession>
    <name>A0A2T6ZD09_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1163630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000390">
        <property type="protein sequence ID" value="PUU73294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD09"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="23468" checksum="78FC8240EDCE1220" modified="2018-07-18" version="1">MFLAFAKLSFFPTGFFISTMVDPVIIDVLPLLFIPPMWLNCNSRVKYGWMESERKPLPVLLQDLIIKALEEKKQSLKNTPIPATPPPMSAPSPCSYSPILANNTRPSLSFTPVPRFRDLTFGACPSRYPMGKDTEMLRVLPVLLPVSIFTQLGLVAVRILPFPVLIPELVCPDCILPPLEALSPQLDRKYTEGCERRDQCSRMRFEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF01</accession>
    <name>A0A2T6ZF01_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1133924</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF01"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF01"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000008">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="374"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="471"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU74070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="562" mass="61374" checksum="F0DD9355169C0A18" modified="2018-07-18" version="1">METSSNGLTANALTEYSSNVPEKGSGRSSPVSSVPSVFKHEDGSPDYLRLILTSRVYDVVKETPVTPAVNTSTALGCRVILKREDLQPVFSFKLRGAYNKMAHLSAEERWKGVIACSAGNHAQGVAYAAKHLGIPATIVMPTATPDIKHRNVSRLGSNVVLYGSDFDAAKAHCKSLEVKHGLTNIAPFDDPYVIAGQGTIGMELLRQCNLENLKAVFCCVGGGGLIAGVGVYIKRLAPHVKVIGVETHDANAMVASLKAGQRITLKEVGLFADGAAVKVVGRETFRICKECVDEVIEISTDEICAAIKEVFVDTRSIVEPAGALALAGLKKYVAINRPTDEKDTFCAILSGANMDFDRLRFVAERARLGEGKEVLLSIVIPEKPKSFLEMMQCILPRSVTEFSYRFGDSKLASIFMSIIVHDRASEIPSILTLLRDKGCYAEDISDNEMAKSHVRYLIGGRLPHGYDSEERIYRFEFPERPGALERFLKSLHPDFNISLFHYRNQGGDIGKVLAGIQVPAGKRGDLEAFLVNLKYPFVDETENAVYKKFMTPIAEKVNGVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFF8</accession>
    <name>A0A2T6ZFF8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 16">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_470127</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 16"/>
    <dbReference type="EMBL" id="NESQ01000312">
        <property type="protein sequence ID" value="PUU74231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFF8"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU74231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="231" mass="26145" checksum="92870BFC66B90023" modified="2018-07-18" version="1">MPKSNAPTRRSNSPVKSAEPRPENIFLFIPNLIGYSRILLAGASLYYMSYHPHYCTILYSFSCLLDALDGYAARKFSQSTKFGAVLDMVTDRCTTSCLLCFLSSAYPKWAILFQGLISLDLASHYMHMYASLDRGAGSHKKVEKKRSRVLNLYYSNNKILFVFCAANELFFLAMYLLSFPQFSSEIHSWPWVVAIATFPICAAKQWINVVQMVKAAVSLAEGDLEQRRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG81</accession>
    <name>A0A2T6ZG81_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1092687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG81"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="127" mass="13989" checksum="D710F352A027402B" modified="2018-07-18" version="1">MAASTMSTSGTFIVHVLRSTTRAAHIASLFSKAKLPTSPWESVRDTQLREQGLLGREEDVLYRLRCEAYKSVQIEDHQFWVGKVVGVDLLVGEEEAGFGLMYAEGMFRDVGRKVGSDEGVYVDDGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG95</accession>
    <name>A0A2T6ZG95_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1158445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000299">
        <property type="protein sequence ID" value="PUU74444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG95"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="420" mass="37331" checksum="81B709DACF86E9EC" modified="2018-07-18" version="1">MARFASSIQKLPTTFLMSAVELSDLEAGIRGRSMSASGTGGANAGCRGGTSGRGGGPSRGGGGSRGPSGSGGGGTGPCGGSGEALGSSSGGKGRSGGGGGTSGRSDSGGRRPPSGSGGSGGGGAPGGSGSGSRGPLRGHSSGRGGGAGSGHGGGEQPSGGAGGAGQGGDRGGGVPPGGRGGRARGGGGGEGGGGDAGGSGGNRGGGNGGGGGCGDGDGGGGGGGGNGGGGGGGNGGGGGGGGNGGGGGGGGGNGGGGGGGGGNGGGGGGGGNGGGGGGGGGNGGGGGDGGGYIVGKKQEDTCGHNCALTPELLSPPHNCPPPVCPEPVCPRPVCSEPVCPRPVCLLPMCPKPWCPLQVCECPLPVCPPPVCPDWNKQAAVRAALAGYISAEEHINLILDLYNYLLMLEEELAECKGGDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGE6</accession>
    <name>A0A2T6ZGE6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_435964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000294">
        <property type="protein sequence ID" value="PUU74526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGE6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGE6"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="86"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="2">
        <location>
            <begin position="333"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="489" mass="53990" checksum="B4BEBEB29BBA25C0" modified="2018-07-18" version="1">MAQVNQAQSNIPGSWSGNKGSNSAYGSYNRFTTIVLPGGTDSGARSQSGVFGAGEAASRPHRLIPYCRNSRFTGRQSLLQAVKGFSECEGHNRVALYGLGGSGKTQIALEYVHQRAAESNCHIFWVQGSGVLKFSEGFKAIAQHVRIPLARAKTDETGFLLSVRRWFESPNSGSWILIVDNADNEADFIGNNSPIAKFIPQGTSGTLIFTTRSRLVASRQDCRMIEVGKMEEEEAQELFSKRYCGWGGLKDREKEAVAAILSSVHHLPLAVVGSAVFMTENATSPSIYWTILQENEGRMKHLLSRPFCDIHREVETESTLGTYFTTFDQIRQQMPPAADLLRLMAFLNHQNIPEELLTQCGLKGMDHSADFRCAIGKLLGLSLVTSAECQDKTFYQLDRLVQLSLQAYLQTNELNHGRAAALKAISRVFPQSRDGRQYIDPVYIPHALAATKDSTDPVAEELGFRVALYLLDMGSYDNADIQFRGCTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGN2</accession>
    <name>A0A2T6ZGN2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1092246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000283">
        <property type="protein sequence ID" value="PUU74647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGN2"/>
    <dbReference type="OrthoDB" id="5323222at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="279" mass="31975" checksum="1C1C37313B384D03" modified="2018-07-18" version="1">MDKPTSSPTLETIARTIDEFSFIFTGFPPRLPPSVKQRHYRTIDDNHYLPTNLSNVYPSLSPQRDFAFQSFERKDKPPPPPPHHNYLREGRPEEAESATPPYIHYYSDPSALSAKSCGSRESGVPSSLSTESESENKSKGYPHPQYTDTLTTAELEMMNHHARPPTTKKRYQLPKDYTKLPHFHPPRFSRRLRNLVAERRRPMRLHLVPVVREPVQDEEKGQAPESYWVITSSDVEAAHVKSRRSWGTMNKRILLLVVFAALFGGVIMLVLAMALGWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGQ2</accession>
    <name>A0A2T6ZGQ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1196050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000281">
        <property type="protein sequence ID" value="PUU74667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGQ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGQ2"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="117"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="34698" checksum="B3EFE5156C4CACFE" modified="2018-07-18" version="1">MSLNRSLLRNVYFYDAANPGVILGGLFRNGSITEANFLDILGIILIVEGNPLRVQERVLGHIVSRTDTPLKIGVYDIYCDASIRVENEPWIPRSISHSATARDDRFCHEVRDRDRRCVISGLINPEAHIQADNWSGFQPAHIFPPEHESLWTQCDYGREITDIDDTLGTPKIDSCQNGFLLGSGTHTKFDQYLIAVNPDDNYKIVVFDIDIFGLDGRILDPVCRNPDDPRRVSDQLLRWHFRQSIFANVRRVREPIFEHDFPPGHDVAGEILAGPYGQERFALEIASRLRGFLKDNRFCHEETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHI6</accession>
    <name>A0A2T6ZHI6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1091415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHI6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015738286" evidence="2">
        <location>
            <begin position="16"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="13231" checksum="2503EE522108F989" modified="2018-07-18" version="1">MPVFVGSFLIGLSLSGMVLKLFPVLHSSNPVLCFSAPSPGGCSETETRYDLLMRLDFPDRLLTSLHYPWIRHRGELWQQPVCTGFFLAFVFVSFIWIDFIVGRAVRSHTVVVLCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI10</accession>
    <name>A0A2T6ZI10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000249">
        <property type="protein sequence ID" value="PUU75137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI10"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="274" mass="29680" checksum="C446137AAFE3F1C5" modified="2018-07-18" version="1">MASLPPSAPYLWLEYDGILPDSSSSSSCNSPSALYHPTQVSSYEAQVLSDSGGPLIVFGSEGESKELASLNSFDGQGILMSPDLAAYSWGMISGERITDNGSIDNFQSQATQNNQRASNYTAAVGDLDTSFHNLLDLSHKLPYNLPEQWISSSHRRGGQQPQIRKDQDLKRLHQTISESPSPVNEAVEKALFGIPIGFDTIRLLLFITLRKSGNAIFARPGSIDVTTVTITWPTNRKAVKGFKRKGDGVNRARTSSQLPGLTPGSLESLIPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIR6</accession>
    <name>A0A2T6ZIR6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1067482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIR6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIR6"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="3">
        <location>
            <begin position="175"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="2">
        <location>
            <begin position="374"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="503" mass="57360" checksum="30A88B2FC93D705D" modified="2018-07-18" version="1">MVTYLRRLKTSSVPQDQDLFACMIHGVFDEYHCYPSYPLQALATTSVLFSSIIVYKLIDEVPLRGVLAMVWQAVRDHDPSSTMYKIGLQALVQFKDRLKEWKSYCGLLAQIAQDVISGNVDRPSELSVNGNIDQGEPGAVLTNGDSNASSPESPQHPPFRSLDPTMPFRDPSTYTELDEKVQDGVLFILNNVSNSNLEAKLEFLKEHLREEHHQWFADYLVVERAKHEQNYHKLYLDVLDKYNGKGLIAEVLRETYVNVIKLLNAEPTLNSSNERAHLKNLACWLGGLTILKLYLKFEIEVLCKIWIWTSKPLNLQQASEELEIGQLRKKRRVYRLLKIFLYTHKIFLYTYKIFLPPQIRFPLVPAGFADHVIRILQLAMDCAIMEIIRSVVERSATIASISTSQLIQKDFATEGDEGKMRNTAHIVVRHLARGLALVMCKGPLRMSMQNNIRALLAKSRYNEQVITDQTITVCVNDNIDIACQIIEKATQERAIPDIDDGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIS6</accession>
    <name>A0A2T6ZIS6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_353906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000234">
        <property type="protein sequence ID" value="PUU75398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIS6"/>
    <dbReference type="OrthoDB" id="5416213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="222" mass="23281" checksum="7AFCB22F1CC16044" modified="2018-07-18" version="1">MQKSGRGGRGGPVKEPTEIISEAWIKPIKELRLVPKGWEIPPPRTYPIPFWVEQHNITLPKWMFDARGNLLDDLKFDDYGQGYTCNIYEVFWDGTQSTAPRSAGFSGFAGGGGGGGGGGGICRSYQNTGTCNFGDRCRFSHDSDGGQRQFVLPERPGQGRGGGGGRGGGRGGDQGGRGGRGDGGGRGGRGGRGGRGGGGGICKFHNSPQGCKFGANCSQRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIV7</accession>
    <name>A0A2T6ZIV7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1067444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000233">
        <property type="protein sequence ID" value="PUU75412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIV7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="114" mass="12969" checksum="1364882D57AE7B10" modified="2018-07-18" version="1">MTDPASLQLTRFYHLTQKYLTTRTSSELQRMNNKKMLYFLPAPNYQRHNNTAVNTTGSLNHNANAQSHNSNAVNRINNSYTKSTGIVVNYTSNEIEDGSAVEMARRMMETLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJD2</accession>
    <name>A0A2T6ZJD2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF924-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000223">
        <property type="protein sequence ID" value="PUU75600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJD2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJD2"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.320">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25488" checksum="FED570BD6C3BACA8" modified="2018-07-18" version="1">MSTSTEAESIFTDEDSARILDFWFKDIPDYPSIELAAKRWFQVGAAFDDACRTNFGSLLSKISPLPAATVTTFATTPQKALSLLLLLDQFPRNINRADSGSVYTVTDPLALAVAQHATSSGLRFDLGPEGAWTGIPMRRCWLYLPFEHSEDLGAHRRAQELIEELIRDCKGGKGEEVTGDMLGFLKEHSDVLERFGRYPYRNEAIGRESTKEELEWLEKERPPWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJW7</accession>
    <name>A0A2T6ZJW7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1089653</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJW7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJW7"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="8"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU75772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="367" mass="40471" checksum="3C319B5D6F637672" modified="2018-07-18" version="1">MPAKEGTVLVTGGTGYIGSFTALELLVAGYEVIVIDNLYNSSEESLNRIELICGKRPIFYKADVTDQEALDKIFKDHPHIDSVIHFAALKSVGESTEIPVEYYRVNVGGTISLLRSMEANGVKNIVFSSSATVYGDATRYPNMIPIPETCPIGPTNPYGRTKMMIEMVIEDHVESHPGWNAALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLGQVAVGRREKLKVFGTDYASHDGTAIRDYIHVVDLAKGHIAALNKLRKDKPGCRAWNLGTGKGSTVFDMIKAFSKAVGRDLPYEVVPRRKGDVLDLTAVPTRANEELGWKAEMTLEQACEDLWKWVFNNPQGYRQMPPQILLDALAETRKKLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJZ0</accession>
    <name>A0A2T6ZJZ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000214">
        <property type="protein sequence ID" value="PUU75793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJZ0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJZ0"/>
    <dbReference type="OrthoDB" id="5323643at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015446406" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="176" mass="18885" checksum="9AF7701B859BE00C" modified="2018-07-18" version="1">MQAKIFLSSLLATLLAVGVTATPAGFDARDIKSTHSLDLIATPFQEVAKDLGIKKPRPNGAIITPKDGDVPVPSSVKARDLESLEKRTPGCLYVTSDPNFGGNHAYLCPIATNGGCTAWDVYWRYSISSFGPDDYTICQIFTSTDCSSGGSTPFGYPGYGNLGGWDNNMGSFICWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK41</accession>
    <name>A0A2T6ZK41_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Argonaute complex, subunit Arb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1109829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK41"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK41"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="456" mass="51333" checksum="B3026F67C34719D9" modified="2018-07-18" version="1">MTEPAEASLSEAVEKLEISSVGEEHEDEDVPKLGDVKITKLEEKQPPKKKKKKRNKPKNPRPSGFEEHHVEGPMTPEAALEEQSLYHPTKPFSERIELCIQRYKSKRKFDALRSQIFTTYLTLGGISTGPKQFSGGLDYKQNDHLDKEQLETMAATDFVSTSLDEDDEWEVDFPFVVRGFLSHRVPYVLGYTEVAHLELAAQVVRNFLNYIIYHNVAPEYGDSINEAIRICDMAEKELALCRHTSHRLPGNFNMACSTLFGGHYAGMKDETQTWDTLTPPIGLTIKEATDIFNACVQARGTSEQKEAGLNVEITKAEYMGMEVIGIIFPNLERKRGKDEVKAEEPEGSKANANENGNPTAKPYEATGLKALGRLLVKPWTPDDELPPETDLVEFDIWIELEVLQFCFTGMHLEAKVHRLSSGIFWIDSVTAVQCSFYIQLDPPEKAGDNASDDEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK73</accession>
    <name>A0A2T6ZK73_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Swiss Army Knife protein DSP-PTPase phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1130580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK73"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK73"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife protein DSP-PTPase phosphatase" evidence="3">
        <location>
            <begin position="146"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="326" mass="36550" checksum="0EB1DCC90E2C498A" modified="2018-07-18" version="1">MFPPGHGNDYLNVGDIYRISVFGTNKMLATRGGKIFLEEYEKGYWHQMWICEMNSDRRISLRNRHTKRYLGRRENHTVGCVSSHSGASEWLTFTRLSLGGYSLEVSHEGKNELRPIQRVNNNSPDLKVGEVCTQFGLHRLGKSVFRRFEWVVPGRLARSSAPYYNGEDADENINETSIEFLNGYRIKNIISLNSVELPPRPRGWLRAAGISYSHIKAVECAAVTQDQFDQIRNAYDKAGATIIYCGYGDGRTGMAISAIQLFQGRALDDNDYRENGVQSPSQIAALNALSNRLNSVDGHSGPVDTLDTQPPPYAAPENTASEKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKR5</accession>
    <name>A0A2T6ZKR5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RF-1 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1088967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKR5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKR5"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="19612" checksum="0F296CE47FB99258" modified="2018-07-18" version="1">MPPRPSVKEEEIEESFLKGSGPGGQKINKTSSAVQLKHLPTGIVVKSQATRSRSQNRKIARKILAEKLEFMERGPESRLGALAERDRKKKASKSKKAKRKYTKLEADRQTSDSEGDEEGHAGDGEGESADEQDDRTVGPKLGASEPRSASVIEGKTVTGTRSEVTALNDSKPPNSGKDIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKU0</accession>
    <name>A0A2T6ZKU0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1088997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKU0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKU0"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="279" mass="30436" checksum="3ED90DC69ABBBF3B" modified="2018-07-18" version="1">MIKESALRNKLQELGVPSHGNKRTLHARYDEWMTLWNANVDSATPKSKKELLKELSVWDTINRVPVVQKTKAAGWTDEGWLESNKSHFDELIAKAKAQRVKPKPVKEGKKGEKAEGEVEHATLSSAQADGASAAPTTLPNNITPQPTIPESKVPPNNATQSFQPNFHQPQYLDQAFTATLHSTLRQAYPPPPPPLPQTYTAQTPPTYLSYAHVNTNNMFAANPPPSPPTRLLGVDSNTNKPIAIAEEDTSLIGLYGKRKYEEMEVGGKSGGRGGTSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKU5</accession>
    <name>A0A2T6ZKU5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ELMO/CED-12 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_991836</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKU5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKU5"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="5">
        <location>
            <begin position="239"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="686" mass="78177" checksum="3F4604901AA966EF" modified="2018-07-18" version="1">MDNISELIERLSNDEDAVKKMAVFKLQSNIGDPSFAEIFIAQGGLAKLRKLALTASGNTLAYSLTSFSRLLELDKGWDFVNSELISRVVELIVTHPLVNILRGAMSILVSIVSHPHTSSTRGSYSGPFGFRALKPAISMHPQFLEMLVSRLSSADHALCANSLQLINSLMRDAITNDMDNEWPRFIKRLQDLGVIKAVFILMQSSALQDLAHPLLEFQALTKVLLRRWRDVKVDLEVKEHRIALKGLHLASAPERSDLGADQKADSPAKKKHNPEKWRRLGFETESPAWEFGEVGFLGMMDLTDFVRKDEDGFRKVLLEQNAKAMEYRCPVARASITVTSILYHQFRVDKSEIDDIKTYQVLESRTNYERAFRPLLLQWSRLHTGALLAFIRLWRETGASLEDYEKVTELLRVLIYHVIGQAPRTKEVQEVEEELALFEYLRLRDLQMEILENTYESAWGNHLKHVREELKTEALQFVKEQRIRCLLHGAWFPVSAPRTETSGLKIQMDNKKSTGGWRYVRLSHNRRYLHYCDYENETVYEPKLEELPEKIDLSIVSSVVSNVVPASIDSNSSHGTLTQGASKLASTKITIHGYTDSNPQRAKESVLLALHPQTHSVASEWLDGLLMLLNQQPITSETSKLINVVTNYGLKIRLLNVRYTDDFHTNPPDLPSRDGVDDDYYYSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL70</accession>
    <name>A0A2T6ZL70_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1088671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000195">
        <property type="protein sequence ID" value="PUU76232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL70"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL70"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11842">
        <property type="entry name" value="SH3_Ysc84p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="371"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="430" mass="45838" checksum="A3F89D778EE739FF" modified="2018-07-18" version="1">MGINNPLPASLQSECRKASRILASFVDPKQSFGPDKIIPPSVLSNAKGLAIITVLKAGFLFSGRVGSGLVVARKADGSWSAPSAIATAGAGFGGQIGAELTDFVMILNDSNAVKTFAQVGSITLGGNVSVAAGPVGRNAEASGAASLRSVAGIFSYSKTKGLFAGVSLEGSVIVERKDANKKFYGGNVSAKQLLSGSVSPPHDADALIRVLSSRVFSGNLTGVNYDDMYNDIPTYDTDRDESIWEGQSGNAYGEGTRRGSIGNRNLSRSSTAWKDDRDGGSPRGVSRASTWQDDVYDRDRDRDDPADAAWRASHRPDPAQTFDKYESSKSAQFQRQHFNSTYSDKSPAPKRPTGPKPVFKPKPPFANKAELSANQAVALYTFDADQPGDLGFKKGDIITIVKKTDSKNDWWTGEINGKTGIFPSNYVETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLJ6</accession>
    <name>A0A2T6ZLJ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1066754</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLJ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLJ6"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="10">
        <location>
            <begin position="428"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="619"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="630"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="706"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="734"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="840"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="903" mass="103073" checksum="F21386D1C58245CC" modified="2018-07-18" version="1">MDIDEADEVVVQSVIRLPSASPPPSKRKRSPGSRSRSPRRRRSPPRGPSRFNSFGGADSGRARERDRQLNDRLRRLDVRAERTEKEVEEKPKFDAKAEYEKLLSMRSGGTYIPPARLRALQAQITDKTSKEYQRMAWEALKKSINGLINKVNVSNIKHIVPELFGENLIRGRGLYCRSIMKAQAASLPFTPIYAAMTAIVNTKLPQVGELLLNRLVVQFRKAFKRNDKAVCLSSTTFIAQLCNQQVADEILAIEILMLLLNKPTDDSVEIAVGLMREVGAHLEEMAPRANNLVFEQFRTILHEAGIDKRVQYMIEVLFQVRKEKYKDNPIVKEELDLVEEEDQITHKTELDDEIDVQDGLNIFKFDADWEEHEELYRKTKAEILGEGSGAGSDDDDEGEDESSDEEDEEKQEDKKMEILDQSNTNLVNLRRTIYLTIMSSIDFEECCHKLMKITLPPGLENELCSMVIECCSQERTYTKFYGLIGERFAKLNRFWTGLFEESFGTYYDTIHRYETNRLRNIARFFGHQLSTDALGWHVLSVVHINEEETTASSRIFIKILFQDLAEAMGMKKLQERLKDPFLQEAFSGLFPKDNPRNTRFSINYFTSIGMGGVTEDMREHLKNNAPPPAAIVAPPARSESASSRSSYSSRSRSSSSGRSRSRSFSRSVSRSPSRAQDRGRKRHRSYSSSRDSRSRSRSYDSYSSRSRSRSYSRSRSRSRSNTRPTKKARERSYTRSITGSRSLSRSLTRSLSSRRSVSYTPPPRKSGRARSRSRSYSSVRSYRRRRSATYSSRSRNGSRSPTPPRKAERNQGRSSRSPPTRRGRSYTPDRSRSRSRSRSRGHDGKGSRYDFSDRNGDRPRGRERYRSDARSRDDGDRNEGPVAASGGYGGRGGGGRVRAADFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLQ6</accession>
    <name>A0A2T6ZLQ6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1029021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLQ6"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032783">
        <property type="term" value="C:super elongation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003711">
        <property type="term" value="F:transcription elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027093">
        <property type="entry name" value="EAF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15970:SF2">
        <property type="entry name" value="ELL-ASSOCIATED FACTOR EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="444" mass="48107" checksum="CC0E25D292CC88CB" modified="2018-07-18" version="1">MPAAADKSAKPTVEVTKQGKYNMVIGDSLKQENGYVDGDLFAGVKYNFKPPWSLANSVPPHLTKSEAGGEAPYTLTLTPPSQPSPNHIVYEGAQHIPKKTECILLFDPAKQTFTLEKLSSAFTFNAKVFANAHPPLPLRPPVVDGDDDEISTEEKEDDNPFDYRHFLNKKATTKSRAEQRAEKEERRKKALIAAGALSENPDESEGEKGGKDEEESGLGLGITYGGRPQFSSRVGSNRKAGGKSPVIRGRKKLLAGDRGMAIPSPGARDQGSSSEESEADNEDSDEDDEHYRTPLHQVSPPHKLASKNTQPMDDDDVLELPDMVPQPPSEEEEISDVDDSDDEPNPPRASPPADPVVAPGPDEEDEEEEDDDGFDLAEQLQQALESEEDSGPAVQGGDSEIIFEDDDATSRPKPGLVHKSVVPMSLSRMVGGGVLDESESSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLZ2</accession>
    <name>A0A2T6ZLZ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1088154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000186">
        <property type="protein sequence ID" value="PUU76510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLZ2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="80" mass="8945" checksum="245CC70C17EFE8DF" modified="2018-07-18" version="1">MQGKTTMTQLGGHLTLVLVWEASSSDIRFYTCRFLAKANSEHGVVDVISCGLAWLRHWKVMSLGVYRTIIVSVCIFPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM09</accession>
    <name>A0A2T6ZM09_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1102316</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000185">
        <property type="protein sequence ID" value="PUU76525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM09"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM09"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24398" checksum="D188C4A1A9669EFA" modified="2018-07-18" version="1">MPKTWLITGASSGIGREISLAALSRGDTAIPASRTPETHLLQIASVVAEALRQHENIDILVNVAGYLLEGSVEETNGEQTEHLYKTNLFGPINLARALLPHFRARSALRGAAAAGNYCASKAALRVVTEALRVEVAAFGIEVCCVMLGHFKTNFLDQGHRLAVRGRVDEYEDVLGGIRRGFSAFHGRQPGDPVKAGNVIVGVLAGDGGAIGEVEGLKEVAGYTDLQGVGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMM3</accession>
    <name>A0A2T6ZMM3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_229953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000178">
        <property type="protein sequence ID" value="PUU76723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMM3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMM3"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="383"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="623" mass="67494" checksum="0F0099F8DD6BFF73" modified="2018-07-18" version="1">MANGMQAYNSNSSHSGMGSGNVPNSPAPFIKNEPQDESNRFLHQAPYHHHPDAYGMSGHQQFHQQSGFNEPNYNGGDGSIDPSELTMSPSMPIQQNGGFMESYPNYPSGNNNNVGYMSSGGAVDDEDLLALGNLNERHHVQNNGQFGIEHQEQRHGHGDDYSSLHHLFPEMDGSGDRSSAGENGTSTDQIYSHTPDNNPPAESPFIPSFPAQPFRQLQHPYNGATADTPSSYNASPVIGSDSTQGTNFDQFMATTGKRKNRPVLERNGSRKSPNSRSPHTPKTPGIGSLSLGGESSSVPAQPIQTSHMASHRHHKSLSNQWDGTPGSQISYIDSPLSSPGASHVHPQISDVFKSGKHASLPAKVENQVGTGPAFQTQEAKRRRRRESHNMVERRRRDNINERIQELSHLVPQHRLEDEKVRKHLVNNGSLSPSVGPSGSPPRATSMLAGGVGRRASGVPTSAGIPGEEKDKGPNKGDILNGAVGWTRDLMWALHAKLEQEKEIRELVARLGGTYPFEQNEDDKRMSSELYTAIEKNGVQSFHYSRAPGSTLRVPGYTDYAGNAVGPGGNVLSPRVSPSCSGGKPSQNGGSSRGTPQQQSQFWGQNGDGMAFKEEDEYNSMDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN22</accession>
    <name>A0A2T6ZN22_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_216326</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN22"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN22"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="44"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU76890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="415" mass="46604" checksum="A543E2C61B5A5B04" modified="2018-07-18" version="1">MAFIFSRAACSSPRSLWLCRRSISTTSKFSHSAIHGSSAIAPARTRFAPSPTGYLHLGSLRTALFNYLLAKRTGGQFLLRIEDTDKKRTVEGAEEGIFDTLRWAGLQWDEGPLAGGEFGPYRQSERTELHKKHVDILLREGHAYRCYCTPQRLEALALTRKHSGQSTDYDRRCLNSPPTTSTTEPHVVRLKAPVQYPPYHDLVYGTITPGARSHDHSIGAYEDPILLKSDGMPTYHLANVVDDHLMNITHVVRATEWMPSTPKHVHLYNCFGWTPPKFVHVGLLQDTQGRKLSKRTGDVFVSEFREKGYLPEALNNFVALMGWSHAGESDVLDMRGLVERFSIDGLTTGNTKVEFGKLDFLQKQYARNRVTEGPGGKEILDAVESQVRKKFGEKYTPYPQKPQLSPFTRTNGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNY3</accession>
    <name>A0A2T6ZNY3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1086654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNY3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNY3"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="206" mass="23870" checksum="C621D73AC1A5B4D0" modified="2018-07-18" version="1">MSTTGPEKNHREQTNKSTMENLADSHSFLLPEEFFESFHQGKFTSSTRVTYFPEDNDPSNPVITTGVFLRLSTDNSGEPEPLMLIQFVRPKVWRIRFDPNSTDPDDYDDYNSRTIISDTLTNLRDILDKVEGIRWETEFIVGSEKDQFYTIRSVLYDNDGESQKRTTISELLIYKEFFKIQVLLISDNTTTFSLSFRVFAASKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP40</accession>
    <name>A0A2T6ZP40_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_987644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000159">
        <property type="protein sequence ID" value="PUU77194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP40"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP40"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="93"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="395" mass="44502" checksum="FF0A691EBB9E27B1" modified="2018-07-18" version="1">MSTATFTETAEQPDITYHPDPISYAERTKRILAKNPPQVLPAGFPNKLESELVWEGKDFKDGEWIYHLTESDVEEVRSAVEQFKSQNLPLGLLSPATFPLPSFSKELQRQARILHSGRGFFVLRGLPEYPGPLENTISYVGVSSHISPTRGVQDPNGAVLAHITDLRSQTNTNAIGAPAYTPDKQVFHTDPGAIISLYVLGEAASGGTSRIASSWKVYNHLASTRPDIINTLSKPWPFDGFGGNPKVYYRPLIHYHNGRLISQYARRKFTGFLEVPRSPDIPPITEEMAEALDALHFTAERFALGLHFRRGDIQFINNLSVFHSRDGYTDDETHKRHLLRIWSRNEELGWDIPDALKGLWEQLYYSGLKPEDQLFPLDPVVRRMVPIPGVEKSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPU6</accession>
    <name>A0A2T6ZPU6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1065767</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000150">
        <property type="protein sequence ID" value="PUU77520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPU6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPU6"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01091">
        <property type="entry name" value="CDC68-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000002">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.210:FF:000001">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000006">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000005">
        <property type="entry name" value="FACT complex subunit spt16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033825">
        <property type="entry name" value="Spt16_M24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="13">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="14">
        <location>
            <begin position="538"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="814"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="440"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="935"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="937"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU77520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="993" mass="112053" checksum="68278FB548FB5736" modified="2018-07-18" version="1">MGDEVSIDKSLFHSRLGGLVAAWKDPKKADLFGGVGSIVIILGKTVEGPYSKSLALHFWLLGYEFPTTLFVLTQEKFYVVTTPKKSKHLETLKGGKFPIEILVRGKDEAQNTQNFKDLAEVIKKSGKKVGVCMKDKAEGPFVNDWKKIFPAEIEGVEEFDVSSAISQCLAIKDDLELKTMRASSRALVGIMKDYFIDEMSTIIDEEKKISHVQLSQKIEAKIDDDKFFRAKEMKLGPDFDPLQLDWTVGPLVQSGGKYDLRSSATSDDSQLHGGIILSTMGLRYKSYCSAIARTFLIDPNKSQEKYYSFLVDLQWKVLSEIRDGVVCKDVYNKAIAFIKSKHPELEKHFLKAIGSIIGIEAKDTTTAITAKSNRAIKDGMTLCVTVGFADLENPKPQDSKSKVYSLVLTDTIKVTPGDPIVFTGGCSKDLKETAFYFKDEEPEQKVKEKKPAPKPAPAKNTAVLKAKLRGERKEVDEGAEQKRREHQKELAQQKQEEGLARYAEGDAVGDGKGKKAIKRFESYKRENQLPLSVADLKIVVDAKSQTIIVPVFGRPVPFHIATLKNASKTDEGDWTYLRINFLSPGQGVGRKDDLPFEDPNAHFVRSLTYRSTDNDRMAEICAAIQDMKKNAVKREQERKEMEDVVTQDNLVEIRNRRPQRLGDIYVRPALEGKRVPGEVEIHQNGLRYQSPVRNDHRIDVLFSNVKHLFFQPCAHELIVLIHVHLKDPIMVGKKKTKDVQFYREATDIQFDETGNRKRKYRYGDEEEFEQEQEERRRRALLDKEFKAFADKISEAGKKHENGVDVDIPYRELGFSGVPFRANVLCAPTTDALVQLTDPPFLVITLDEIEIAHLERVQFGLKNFDLVFVYKDYTRPVSHINSIPMESLENVKEWLDSSNIPFTEGPLNLNWPTIMKTVIADPHQFFKDGGWNFLSVESDADDDDEEDEVSEFEADSSDSESEGSEDESEFDDDDASADEGSEASDDESGGEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQG7</accession>
    <name>A0A2T6ZQG7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1101734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000144">
        <property type="protein sequence ID" value="PUU77706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQG7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQG7"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="122" mass="14032" checksum="AB6F70CB52502F0F" modified="2018-07-18" version="1">MCKHILNAQVSLRSPCCKKWYDCITCHAESETHPLLQRFEVVFACKKCKKCFRKDTQEWDESDEYCPHCDNHFVIEAKVPRAVVEFEGEDVRRDARIVRDDRVGGGKGVEGWDVAEGADRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRM3</accession>
    <name>A0A2T6ZRM3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_984092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRM3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRM3"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="19445" checksum="007F25EB36DF5D40" modified="2018-07-18" version="1">MPAFITRRDDDQPSTHENNTMTHLLITLVVLVSFGLVLGGSLFFIRRIRRSRKVAGTLPSYEASNKNHRGLTISTRDSVLVYSEKQQLIDNSSPMPLTPESIPEIRITFPEEEDKQGRRVSGRVVVVEVGEAGVGFVRPLENDGLPPYQQKSEERFASVDLDRIGGLKEKETAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRT6</accession>
    <name>A0A2T6ZRT6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1127194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZRT6"/>
    <dbReference type="OrthoDB" id="192608at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="2">
        <location>
            <begin position="1858"/>
            <end position="2015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2034" mass="221371" checksum="07DCCE7C5F8FED8E" modified="2018-07-18" version="1">MADDSSAIEAVQLDIAKLKTITEEAQQQLYVMSFLNNLEKLVNRLDEDGASAYQLYVKKELFKIITLSAPAPTRLVRNISGRCFAGIFGKGDRKLLFETINELVGLINTGKSDKDLRIRHAAVHCVGEVYRAAGDSAMALSTLTCTSLLKLLKPAQNHCGLRSSIFRALGKVFSTVRDMADEAVARDVWKQARNVAVGEKSALVQASALQCMEELLQATQLFNSHQEYDKLQSVAMKALDSTSTSARKAAASCWSLALVLAYSTEVPELAKVAKKPKKMKRVSTAVGDDEGLGVERPSSPAPSGKKAIVRLTFTLEEILRQLSLHYTKPSTSPRARAGIALCYSGVLERLGSSVVESNYGLISSHLLNDLLSHHAVIANRFRLLTTRKYVRTLLEDVIGRRLLGETGQLNAIKTLVNDTMKDYPQVIKEKPEPSKHALTGALHALASLIQSLGSALASVQDTTRDGLLQVLQHPSYSVQVATSWCLRGFVIAAPSQLLPIITICMNNVNRELSQMTARRPTTTEILRRCAGYANGLAAAISTAPLQPLYASVDITSRILTLATSLLKSSGDYDLRISATQIQVAWILIGGLMALGPNFVKIHLSQLLLLWKNALPKPLAKDSSVERSFLELSFLAHVRECALGSILSFLEFNSRLLTADVSKRIAAMLQNSTLFLNTLPAKKTTDDISQRLSPSLQLIDLDLMVRRRVLQCYAKLVKLSHGEALQANLLTIAVSFFADPDKYTPSSLSTAIASSAGNFESLWDIGDNYAYGVCGFVKGFDVEAFAFEAQGTKPTIAHWITRGSPEARINETKLHTPVIGSIEHDSVSLYTTSNSSARNEPTPAPPATAVVNSAIDLFTILLPIQPPKVQESILEQIATFLASGSLQRDPGRKAAMVINVAVALLGALKVTISEEVPSASLSTASVLKIIQELLQGFVIHPDPYVRNVAYEALGRLCSIGGNSFTGNMINWCVETIVNNRDPNARAGCAVALGCIHSYVGGMAAGFHLKTIIGILMSLSNDPHPTVHFWALDGLARTIDSAGLTFSGFVTSTLGMLSQLYVAETHNEEVATVVSSNLELELPTLSIVVRCIDSLIGVLGPDLQDMVKTRELILTNVGQFLREPDYTVQLEALRCLEHLSLFAASHVDTAGYVKRLQKELGSEYVELRDVAIDGLYQLMKGDAERIVNTADPGLEEQLWIALDEAPEHEGIRNIINNWLNQTGIEDVGKWVGRCQAVMSKLVERKDGIAGKLENEKPTNSGAVDLNDDEVASFAVASSREKENSQPTGQELLRWQVRTFAMNCLFELLSLAAREMQRDSETPVEESLVQKIADVIRMAFSASTSNVVQLRLAGLRIVDQVLKMFGYTPDPDFPEATLLEQYQAQIGSALTPAFAVDSSPELASEAVNVCAGFISTGIVKDVDRMGRILRLLTSALENFSSDSEVASIGDLKGLSSNAQVMVKMAVLRAWAELQVASKEQSYLADVVKPHIATLAPLWLSSLREFARLRFEPDISTNSTGATTLGGSIDTIYSALNRETLLQFYQDSWLKLVDAIASLIEQDSQFVFDALDGKASSGDVNGNGVAHDINYRDEPVAFFFVLFGIAFEALVGRPGVDSLATKEQTLEILLALKKILHPSVCGHAIYQEAIFSETMDLFDRLVLTEGLAVQSATTDIAKSLCVEHPTARSKSGAQGENLTEDIDQLFELTRLMVLVLARLLPNVVDKKTMVRHHLSEEAANLVRVSLDALVHAAEVFPAVIRMDLYASILHIFTSIFGTGVCQTEVVPRSLPIFKRFIRIITNSSGGNDSEMVVMQVRSCLSSILQILDNAKIRGDAALPCLKNCLMASTIVITTGVNVLPPNDEQVPLLCDRMIDALSNPATSKMAVQCSRSILMVTPKTACDQEMVRYMIPRLITFVTTTKGDSEEGSDQTKFLVCHILTSFVSTLFGDQIQVAMALLIPTLLAHASSNPGSYPETAKRLLELVAVSQLAFKNVVANMGAGQRGFMEEILRSNARSIADSTQQQSSAPTIALKMNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRV5</accession>
    <name>A0A2T6ZRV5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketopantoate reductase PanE/ApbA C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1065224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRV5"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="198"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="328" mass="36129" checksum="872145D5E11E9B87" modified="2018-07-18" version="1">MEEKKEIHVLVFGGGGAVGALYSYLLSISPLAKVHTTIVCRSNYPTVSTAGFTLRSALWGNHTFQPTKVYSSLDEIEDTSIYDYILDTTKSHPDAFVGGKPPLARLSPFLPETTPIIVIQNGAGIEEPYHLAFPKNPIASGVLYITISQPAPGEILQEGKVNHLRIGPDHPLPEKEQEKIQFFGDVLGASCKVTVHKDIRCERWRKVAWNGSWNTICAVTGLDTQSFIKSSPEAKELVINLLREIVITAEALGVKMDPIDSLIKDHVGWTIKAPPIVPSMLQDARKGAQMETEVLCGNIWRAAEKVGVETPNIKYAQAYPSEVTRRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRX5</accession>
    <name>A0A2T6ZRX5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1127108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRX5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="13091" checksum="D7E5A6B3607E98B5" modified="2018-07-18" version="1">MVNENTLLPDEDHYICTQVVMYQTRATKDSYVNRIMKNVKSSIEKGKLSYAKGTTKIENWKCGRLEQTWDFQLAYLCHCLSKWHSCCLRSKLDSENIKSDQLRWSSFATGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS41</accession>
    <name>A0A2T6ZS41_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_88910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS41"/>
    <dbReference type="OrthoDB" id="10541958at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="74" mass="8114" checksum="EE027A69D4AD9FCD" modified="2018-07-18" version="1">MIFAALRSLTQTLLSCGFLSSAVLGVYSLRSKRSGIVEIKSQKHGRSIGSSTQNPPIKTPEARSPFPDFSYQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSU4</accession>
    <name>A0A2T6ZSU4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_64425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000116">
        <property type="protein sequence ID" value="PUU78569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSU4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSU4"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22523" checksum="6A8404C978435A07" modified="2018-07-18" version="1">MSSSRKVNNDDPRLSRIRENQRRSRARKREYMEDLERRWQKCKEMGVQANVELQQAARKVIEENALLREILSEAGIVHEEVERRLQVLKDKRKDALAASGAGSDIVSGGNRCEDNGCGGGSRALDGLEEFFNEFELLPLPQAASSATSLAGDSLDLSLGDSVSMGDGGASFSATQNLQTPGYDAGLLEDFPNLDELDTSEFLENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSU7</accession>
    <name>A0A2T6ZSU7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_67068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSU7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="171" mass="19358" checksum="C561F5904C6C49CD" modified="2018-07-18" version="1">MSRNGWTSTIATNGIPRPHERTLLPSTNHTTTTILTIPKPPQKKSIYHTISTQHRITRPPLTIPPAPNRTWKVLYRLLYHHHPEAPFSISRTPLFSSLPSSSPPPILTQFRPQNHRTPNSYSGQLLTTNFFIPPNRAPLAHSQRSNNQHQRLPSKGPQTSCYTSSRPSRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT37</accession>
    <name>A0A2T6ZT37_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_52595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000110">
        <property type="protein sequence ID" value="PUU78660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT37"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="104" mass="12652" checksum="6A8E29313252F772" modified="2018-07-18" version="1">MVGRPHAQKLMIGMCFRFCFFIFHFFFSLVPEELVGDWLCVSFYFFTFFIFFYFFTLSYLKWGIVMGLWWGRLRQSESPRISRKFHVNWKLRLPPESCFGSVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTA5</accession>
    <name>A0A2T6ZTA5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1047945</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTA5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTA5"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="401" mass="43584" checksum="00B2C934548F42F1" modified="2018-07-18" version="1">MASTFTPPSTIIIVGCGVFGLSTARTLSDRYHSTKVLVIDKHALPCPYTASIDSSRIVRADYADPAYSTLGQEALKQWARHPAFRKTGLVITADGENKYLKDSYNNVKSEGGVEYLPTEKDIRSLMAGGYSGTSGYVNWNSGWVDAEAAMRTLYSEVESRENVQFLIAEVSRLLYSGRKVLGVKLANGEEITAGLTILAAGAWTPGLVPLHGRAVPSGQVMAYLTLSREEATRYASLPVLLNLTTGTFIIHSPNTSPPTLKFARHAQGYASATPVFPKTIPREGEDALRHTVKQIVPEFSGRPFEKTRVCWYSDTPDGDFLVTWHPEHEGLFIASGGSGHAFKFLPVLGNEIVGVLIGKGRFEEKWGWKEHVEGLGDGSRGGDGGRVPLEELLLEGGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTK4</accession>
    <name>A0A2T6ZTK4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000106">
        <property type="protein sequence ID" value="PUU78805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTK4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTK4"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="211"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="374" mass="41751" checksum="E8CA12ED7E6C81C7" modified="2018-07-18" version="1">MAQRWQEILQGVETAVFMKFAAAPAFARRGQIDASLEEVGWRCVGSLEELVFGQGTENSDPKNGRWNLRGKRFYKPTTLNGYGLLYVPGGHVMRVDQRGIDTFTKTYGQQFPCYGVLSNPRCSSLWAMANPQGDFEPQIHELTSKLQTSNGVRPNLIIFILPNAAVKPYCTIKKICDTTFGIASQCIVLEKCFNPKGQLQYSGNIALKQPEMIMGCDASHPSLWQPRMYLPPPTFTAISASYDRRCAKYSAVTSGQDAGQEIIQDFGAMTQELLKRFQEQAKRDPAAIVYFRDGLSESEFDKVVRYELSELKKVTKAKVLLYWFIKGELSKSPKPGDVEKMIQNAAKNQSLKLGAEQAQATSKVTKAKTVVKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTV9</accession>
    <name>A0A2T6ZTV9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1101122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTV9"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="190"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="254" mass="28514" checksum="EC45E13E934FBAEE" modified="2018-07-18" version="1">MASSALSDEDVSTFIPIIDAILFESDLTTVSVKKVRNGLQTKVGYDKQIDLLIADRFENVLAQREFDNGVKQEEEDAEGEDEDEYEQEVKEEVSEDSFSTAPDVGNAVKHEYSVTPSKRSKSVVDEDARLAAELHAQWNSGRPSRSTKKKPVKPAPKVRKSKKSDAKVNSEGSDGEKPTKKKRKANPNSPFMAPLILSEPLSSLLGETMLSRPETVKRIWAYVKERNLQDPEDKRYIICDDSMKPIFGNKIHML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUD2</accession>
    <name>A0A2T6ZUD2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_980543</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUD2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUD2"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="319"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="595"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU79108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="830" mass="92214" checksum="632010D3D99D6FEA" modified="2018-07-18" version="1">MNMAIKRQLFARSDRVKGIDFHPTEPWILSTLYSGHVNIWSHETQTLVKTFEVTDVPVRAGRFIARKNWFVVGSDDFHLRVFNYNTSEKIAAFEAHPDYIRSIVVHPTQPFVLTASDDMTIKLWDWEKGWKCVQTFEGHAHYVMSLAINPKDTNTFASACLDRTVKIWSLGGGGNANFTLEAHETKGVNHVDYYPAADKPYILTTSDDRTIKIWDYTTKSLIATLEGHTSNVSFACFHPELPVIVSGSEDGTVKIWHANTYRLEQTLNYGLERAWCVSSQKGKNAIAMGFDEGCVVVKMGREEPAVSMDAGGKIVWARHSEVLTAIIKPSDVSAKDGEPLSLPSKDLGSCEIYPQSLLHSPNGRFVSVCGDGEYIIYTALAWRNKAFGQALDFVWGSRENSNDYAIRESQTSVKLFKNFKEKPGGLDVGFPADGLIGGVLLAVRGQGSVGLFDWETGGLVRRIDVAPQNVFWSDSGELVVLACEDTFYVLRFDRDEYVAAAQNGTVEEDGVEAAFEVITDINETVRTGEWVGDCFIYTNSTNRLNYLVGDQTYTISHSDHPMYLLGYLPRDGRIYLADKDVNVLSYALSLRVVEYQTVVLRGDMEAAAEILDDIPEDQKNKIARFLEGQGHKDLALEIATDPEHRFDLSLSLGNLDTALEIAREADVEHKWKTVGDAALLAWDLVLAEECFRNAKDIGSLLLLHTATGSQEGLKELAGSAVTTGANNIAFAALWQMGDIEECTELLVKTARTPEAALFTQTYKPSLTTEVVRKWKDSLKENKKGKLSEAIGVPGEDEELFPEWDEYLRLEEEGGGDLIDVGEVDGGETDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUK4</accession>
    <name>A0A2T6ZUK4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1064426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUK4"/>
    <dbReference type="OrthoDB" id="2959714at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="19027" checksum="2589E72C3617F47A" modified="2018-07-18" version="1">MDRRSTRRLKRCDDQWYISLCIEKFYFYCLTVYIKKIQVPHVAGYGCVLVESGFHPARGPTDLGFLSMLQVLGDQNVKFVRGEPVTFPVFIPQFLDACMDFMRGYTFVDGGSCRTPLTDMDDLSEFLALDCHHQQDRLLAKVKNGFSWQHILPDRSCVWREGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUM4</accession>
    <name>A0A2T6ZUM4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1177010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000099">
        <property type="protein sequence ID" value="PUU79114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUM4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUM4"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="137" mass="15028" checksum="9CDA59EE416E3E5E" modified="2018-07-18" version="1">MTSQMVTLRAPDLQWWLDHLDTAFAPDVSVDLFVGALKRRSVKGPEAAAIATAQLFLRLIYAHPFSSIGDLVNHISSIGTELSKAVPRELAVRNMARRVIGIIREEAENNGMGDLFQAALETGTPPGFSCPCKECRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV11</accession>
    <name>A0A2T6ZV11_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_979870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV11"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV11"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="262"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="481" mass="51622" checksum="AD6530C38AFD268B" modified="2018-07-18" version="1">MASPVLSVSPSDVTLPLILSSYKSLPITISAEEKPAVSRLTLPNNDSVAGTNTIVSHLSTLIPLFVKTTYTDIESAEIHQWLTLTSTTPIPEETIARLNGNLKFRTTILGEKLSIADVAVYARVKGQVASWSDEQKTGEKGYRHIVRWVDFIQNTPDLGLQIPTEEKVAVDPSKVLVYLEPEEPVKEKKKEGAAAGEDSKKKGKGRAAAEKVKEEAERVKEGVLDAAGKAAATVASKGKQSKREKREKPKREAPKKEEPLISPSQIDLRVGHILYCMPHPNADSLFVSTISMGDPEGSALVTPHSELSLPSTVLTKFTPLPTVRTVCSGLNGLVPIEEMQDRKVVVVANLKPVNMRGIKSAAMVLAASPAPAPGEDSTTHKKETVELVTPPEGAVTGERVCFEGYKAEPEAVLNPKKKIWEQIQPGFATTSDLDVVFDREKAGWTGDAAQGKAPGEGPTGRLVTEGGGVCKVKSLVGAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV78</accession>
    <name>A0A2T6ZV78_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1081878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV78"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="10076" checksum="BB49B366B1D7CFB4" modified="2018-07-18" version="1">MDVFAPTTLQTKRYLILFLSVYITWVMGISSGAAGGFQSLFAIFFHITIVTLYFIIVIRRKGRTSLKISLTFIILFLLNQQGYLSNEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVF2</accession>
    <name>A0A2T6ZVF2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1192625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVF2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVF2"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015730145" description="EF-hand domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="208" mass="24219" checksum="2B5EC7CB798BEC28" modified="2018-07-18" version="1">MLNPTPLLLLLLPLLTLTTAQPPNPNTSDPPPPETSKTWAEQHLEQEHHINNFDPGAFFTLHDFDSSNTWTRDEVLRFYGLSQPDTINTISEETKSHVWRTILDSMDEDRNGEISMEEFLKFCRGGNTLPDFGLGPGHHGDDEYEYEIHHFEKFHNEDTTEEELTHPEDIEHFRKHDQEHEAEERQIVLDMKPIIEQNIPRKFLVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW46</accession>
    <name>A0A2T6ZW46_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_978160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW46"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW46"/>
    <dbReference type="OrthoDB" id="5419268at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="39513" checksum="21E7DFEE111EB1CA" modified="2018-07-18" version="1" fragment="single">YPTPNHWVLESEQIRALWAHHLQFGKQPDARLKRHSLLMLEKSQLALDIPPTESAIILDQDSDEIVAMVYRNFIPTQYESILDWINGVIVAGIRRKKSAKLEDPGRIVQTGYSAGSRSQPRFDWAKNLLSRAKTSTKNELEGVEYMESSVFALFWNMARRIVPSVISDDLETFLSSGITRMDAKGKQRDNTTYTIKYDSKIYEFKQGELAPPVGFMASNYSRYEILTKKIRAIHKESGPHKYSLFWTTERSLGEDEGGNFFIADYGIRVQGAKNSMVVWQTNMFHGTSLAKLESIDSDQGRGQAGLSIISPNRLPKMWDNYMKERVDKNTLEEELEEGLGEEEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW56</accession>
    <name>A0A2T6ZW56_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc-ribbon-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_793186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW56"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW56"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTCHY-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="267" mass="29326" checksum="48020CD75B242EA2" modified="2018-07-18" version="1">MSISLEGEHKCIERSTECDCPICGEYMFTSTQTVVFMTCGHSIHQRCYYDHMKTSYRCPTCARTIINMESQFRALDLEIETQPLPEPYKNWRCLIGCNDCSAKSNVLFHFLGLKCENCKSYNTNQIRILRPEDGQDGGGGNMSPSAIPRIPERTTSSNSLLGGQANSPPRLAPAEGEAALANANRAIAAAGEAIMELDGVEDLIIDDGWETEDSADYTDIDDDDDLSGFGGDGVEAVEEDSEEEDGDGDDDDDDDDDDDLIQLIGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWG0</accession>
    <name>A0A2T6ZWG0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1080788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000081">
        <property type="protein sequence ID" value="PUU79818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWG0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="217" mass="24416" checksum="25A95C9003D910D8" modified="2018-07-18" version="1">MLHNQQREPAAGKTTAVPEAYLAFLSMPFVLRPFPFIPFYIEVCATLARVHDRNLSLDPQKFHPLADRLLPLLHTHTHRYTETHTHTHAPSLPPSILLFLLFLFLITMTPKPKRPHSPDEDSLDKPSLPPPSSGVTRGSSKAKKRSKMDSASASGQSKNLLQLQTDTQSFSTGASSPHEKNKVPLKDAYKMNPVRYVFSRHLFFSFLFPSPHVFIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWP0</accession>
    <name>A0A2T6ZWP0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1124454</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWP0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWP0"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015787305" description="glucan 1,3-beta-glucosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="88"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU79911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="423" mass="47068" checksum="8A381076A5E68D74" modified="2018-07-18" version="1">MRFKSLHLLTALLVDGVQSSVLLWNRAKSDLGARALTFDYANVKVRGVNLGGWFVLEPWITPSLFEPFGGSVVDEYNLCRTLGKDACQATLENHWSTFYSQADFQQIAAAGLNHVRIPIGYWAIRPLPGDPYVQGQLNHLNNAINWAGSVGLKVWIDLHGAPGSQNGFDNSGKRDSIEWQQGDNVQHTIETIRDLARIYAQSQYNSIVTAIELLNEPFGPSLDRGKIEQYWKDGWGTVRDFNDIGVVIGDAFFDTKSWNGFMTTGWDHVLMDTHHYQVFDGGQLLLSPQGHVSAACSFGRSLVGVDKWTVVGEWSAARTDCTKWLNGVGRGTRWEGTLAGGPSKIGDCGNRVQGSVASYSPEEKANTRAFIEAQLDAYELVNGWFFWTWKSQGSPDWELRDLLANGLFPQPITSREVNNRCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWU5</accession>
    <name>A0A2T6ZWU5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17/PMP22 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_773202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWU5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWU5"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF113">
        <property type="entry name" value="MEMBRANE PROTEIN, MPV17_PMP22 FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32151" checksum="6F1747D4B7571BA3" modified="2018-07-18" version="1">MSTILFNAASRSIFRRLATTPRKLPVPPSAIRFPRAGRPITTTPTPAHNHTSLIPGPASINGVATIPYYSQYGLNPIVRAFRSYGNAQRKRPYITQLLTSVAIYALGDLNAQLLFGGDEKYDPLRTGRMVMIGSVFSIPSFVWFTKLGQSFNFRSKILAISTRVLVNQIFFTPLFLCAFFTLQNTFQAGRFVSPKETVEKLKKTIPTAYGNSCKLWPAVTAVNFWIVPFEYRALFGGVVAVGWNGYLSYLNQASQTTVIPATQPVEIPAAPKARVVVQKPLVSFKPVVALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX62</accession>
    <name>A0A2T6ZX62_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1173520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX62"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX62"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="739" mass="82262" checksum="27F833F5BB7A2BCB" modified="2018-07-18" version="1">MARQKEFAPMVNWLYDLILWSFSILVDLFFREVHPRGAFRIPRRGPIIFVGAPHANQFVDPLILMRAVRLESRRRIAFLVAEKSMRRKFIGWLSRCVGAVPVSRALDMTKPGAGRIYLPDPQQPLKIRGVGTKFTEELVTGGLLSAASAEVIEILSDEEVVLKREFKGDIALAQLTQESEEDGKGSKYKVAPKVDQSQVYDAVFQRLNSGGCVGIFPEGGSHDRTELLPLKAGVAIMALGALAANPDCGLKIVPCGLNYFHAHKFRSRAVIEFGAPIEVPKELVDQYSKGEKREAVRALLEIIYNGLLAVTVTSPDYDTLMAIQAVRRLYKPTNKKLPLPMVVELNRRLVTGYTHYKDDPRIIHLRASVSEYNRQLRLLGLRDHQVEYAKFSFFRVIFTLIYRVGKLVFLGTGALPGFILFAPVFVATRIISHRKAKEALKASTVKIQGKDVMASWKLLVTLALAPILYNFYVVILCWWTYRHRLFGLMPDWMPIIGVAIFGWIWFPSITFAALRFGEIGMDIFKSLRPLVLSLNPTSANTLHKLRQKRAQLAIEVTDLINELGPEIFPDFDSTRIISDPFIKPNALPTINTTSRTRRDSELSSDSNISPTSESGGGASYLSIGVGSGLGGNSHNIPRNESFGNLGSIGLFASRPVSRARSRSNSGGFPIKALSNIEGAGQFGFDEVSRKISSAMAERRKERSRRRSGSLGWGEEEVDGYQGSTSESEGDEEEEDKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXL0</accession>
    <name>A0A2T6ZXL0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1080007</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZXL0"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="317"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="932"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1175"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1442"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1743"/>
            <end position="1922"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1955"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1141"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2385"/>
            <end position="2463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2485"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2501"/>
            <end position="2517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2534" mass="283796" checksum="CF329CFFF136AC36" modified="2018-07-18" version="1">MSGIHQQRSQSPRLENGRLERKPSIHAHHRQTSIVNGVQHRSGLHSRSGSWVNSPATSPLSPPPVMHATITARDMVHIPQIPLSPMAPMISTSMAGSVGGQIQMPQFSSATTSAPPNMNGGNAIGVGSGGGLPGSVPNQQVMAERSPMITHQSSPRVMQFQKPPGTRAHHHSHSHHHNSHHRSRDEETKTPAEYALHILFTQFVRVAERKINSCLPPNHLLDTEPQIETICGAGVDPAFDKLIGSLGYIARHKPKPVIDSVMFWRKSKSEAAAISRQEMSQQTRGLPNQMMPRRNTEPLNGMDGVNQGMRESSLVADRRSTISIYILCRVLIEVIGQTTLDCVTEDMADKLEDIIFNQLRSADPDTLASSPLRMANWTLFGQLLGVMSSIDFERVTDRFFADLERMGGVAAKDTEAKVELVVRGMSYIKLRFFPENALQESADFMLSLANFFNKSHGFRVKRSYCEIFSKLLLPVASTAKTELNYPTWQEFVNLLHPKLNDMMTKPRHWHTAFPLMGTLLCVSPHEFFAQCWLPLIESNLPKLRDKDRSMRVPIVQTLARLTWTYLFRCSESMNNTAKKLERIIQILLTKEKKEKSLVTAEQQVVEPCIQLIRFIGFKYQDLCFRSVVFPLLNVDLLSGANTLRLEQLSPEGMMVGIRAFLAIMADLEKGESGLPPFPETFASSPPEKIPPTSTWLAKIEAEKKDGVKVKVDRRSQAVAVEKLGSTAKEYYDRFCEILGRIIVLCDINFGGQAVLDERFAGPPKTPQENKFSFGTRDEPPAISEQKQSFYELLHVAIQALPRCLPPNIPFYKVVNLLCSGTAHIDQNVATASANALKSIARQYNSQQVIIGFARFIFAFDERYSTTSDGGMLGSGHIESTLKLYIELLRIWLETIKQKVKGNRDAASDSPALDDRGLGNRCDDLEYSNVQAHVDEIESNGLFFLCSQSRVVRRFAIMVLRIITEFDVVLNEPADIGGKISGHSRKPSHLSNSPAYPRVIHILESDSLNVMNLNDENLPVAERSRLQRELKDSKSKDALVQMAISDNQYDASLWFRVFPSLIRVCVERCPTTVALCRDLVCGRLAQMHQSICAIAQTSTAPSLGTFEIVPKPIVRALPPTSPESMIEQWKLYLTVACSTLTSTDGEKTAPRPRTPQHARKPSKNQTPLAPYHLDRITSARSVFGMVIPLLIMDSKSIREAVVAGLGSININLYKTLIESLQPTVLKWNPEVTIRGGKQLNAPRRNRRQDRLRAQVTHVFQLTSHFLQKEEVYRDDWILRHMVAFIKDMKTFLSDPEVQNDWEHQKLRRYFCGLTEELFEGIKKTDHPIRWLPFEGRLSIFILMQDWCGHGPNWQAVKDREDKMRRSVLEFEKDPTDQGTLTAAMEIEKRNLKIAALSAMASLCAGPVVEDIESNAPLQFNVDGLFRWIESIFATPSDRTHRIGRRALKNILLHNQKTNLLNNAIRLCYVYDSSAKATQSYFAVISEVLREMPDYLEGAWKIMAVCLFKLGDENAEVRLQAAKLLRVTEEREYGTSRVQDFEVSISDKTVAVYKRAQFQLSKNLSMACPDQAMLIFSELTMFFNHTEGKAQRDILHALLPWIQTIDLALEPNGDLLPSSYMVLANLYEITVKFSSKIHNEIQAVWQSLATAPFLGNVQVILDFIFNQSLERREQNFVEFGKQVVVFLSETMAGAKLVEALTAYLQPRLMIITVKEPSPVPDASQFPYVADLSKCVPNSGKPTGFSYGHLAMILMVDLLVGPVPEMLEKLTLLLQVVFVLWDHYVPLVQEQAKEMLIHLIHELVIPSLSQEENTSTRLATLEFIETVRQRDSKTFWSYDEISSDEENGLRVPKSMGHMIPCVLEMFSAVDPGLKASWGRVALSWATSCPVRHLACRSFQVFRCLLTSLDQHMLADMLARLSNTIADDVTDIRLFAMEILITLNAIITEMDEESLLQYPQLFWVTVACLNTVHEGEFMEILSILEMLLVKIDLSDSAKVAYLMNAFPPKWFGKFEGLQSLIDKGLRSSVSYGRTLAVFDRLNMIPTNELVGGDSRLLFAVLANLPRLSQAQDDGAPSDEDMACAGRLRALAEARECKSLTRVMMLYVGQRFRNKKDFMTQTVNALKETFFPTYEAQALVFLVGLLSNKLKWVKLKTMQLLTIMLPLIDMRKPAFAGVGADLISPLLRLLQTDYVEQALEVLDKMITISGGPMDRHVMRMSMGNRTIRKEYEKTQTLFGIPDESGWAIPMPAINAAMTRDNVHAVFYTCTQAAVAEEEEAPPTPDVQFHMEDYSYTSIQDRTGTMLSEDGRGEGGFSDTVLRLGDLDAFFGGDEGISSHNHTPSQADAEFIEGGETAPQVYDSRVYAILNRSLARTPSVTSFQTSFADSLCTPVPRDQQPGVMTPTAFTAPPIPPGRGYTPRSVSSPQLRNMGRAGEESLSEAEEEYDHLNNSDVDPGDTGGLPSREGAQDSAFLLDNLLDRLGEGGRAGMRRVFKGGNKEKSGTPSPSARAPSRGPANRAPKSPKKRGDYQPRMASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYM7</accession>
    <name>A0A2T6ZYM7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_716597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYM7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="152" mass="17151" checksum="0661021223C2FAFD" modified="2018-07-18" version="1">MWRLRVLVYPPLGSQKIGWLSAKAYSYRGRNFLNSRRRLYPFLHQKVDLVKKLQRQAPLFETNQPSIKSIPVERPSLAFSLISEIWKFGNLPLGEATAELYQISIPHHPSFGSTLKAVHTTPERDLVIGEGLCMIGGLYGWKVGMAGLSLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ89</accession>
    <name>A0A2T6ZZ89_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_973536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000056">
        <property type="protein sequence ID" value="PUU80819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ89"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="109" mass="12701" checksum="C02F52D6298C4D7D" modified="2018-07-18" version="1" fragment="single">GRQPREDANKRKQRITPVKETALIDGAYQLKQWGFPPKFYTFVEIVTNIYRQRVSDGTLGATWLRGFYKRHPEVKSRYSQPLDYVQSVQGNNLEAISKFFQIVSHSPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZP3</accession>
    <name>A0A2T6ZZP3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1168905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZP3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZP3"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF91">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="10">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="10">
        <location>
            <begin position="270"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU80915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="634" mass="71403" checksum="CBFCDC499E366FB8" modified="2018-07-18" version="1" fragment="single">AHPSSSIIFRTITLEEPAKVLLLPFLQAEHRREVTNRTRRPPRLARVLFDAIEEDRSLELCDSVVDVTLGEEVSFDLIEKKYHSPLNADEIAIFPEVATASPLFQEALAELNLPANVVIVIDPWMYGGWENPKETSPRCMQGLVYARDPKTNNPDSNHYAFPIPLIPVMDIYKREIVRVDKLATGGRDDGLKYGTGPKNALDHCRAVEYIPELVEGGLRQDVKPLNVIQPYGPSFTTTGSLVEWQKWRFRIGFNPREGATIHDVWYDNRSYFDGIMNDTSGKGIVSKNVVCMHEVDDGILWKHTNYRTNRAVVTRNRKLIVQFIITLANYEYIFAYHFDQAGGITIETRATGVVSTVPIDPGTTSPWGNVVSPGALAQNHQHIFCVRIDPAIEGPKNTVIQEESHPVPFTPELNPWGNAYEVRQTMFKRTCWADAAPHNARLFKIVNQNVRNPISGRPVGYKLVPSPSQLTLAHPDSIMAKRMAYASHHLWVTRHRDGEFWAAGRFTNQSSVESGGVKDMIERNESIENEDLVIWHSFGLTHNPRVEDFPVMPIETHQIHLKPADFFTKNPAIDVPSTKNQTSILYKVGGLVSGFVAEVPKNNKENERTRQAKLVTADDSSTEQLVQGIKSCCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZS5</accession>
    <name>A0A2T6ZZS5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1043904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZS5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZS5"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="189"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="287"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="454" mass="51777" checksum="FF86E2A15604B669" modified="2018-07-18" version="1">MLDVLSFIEARGGNPEVIREAQRRRYAPIEAVDEVIALYEEGRAARFNVDKKGREINTTQKEIGAKKKAKEDASPLLEQKVKLEAERKDLEAIAKEKEKQLYAKLGTIGNIVHSSVPVSNNEDNNELIRSWTPEGVNIEKRDCLSHHDVLSRLDGYEAERGVKVVGHRGYFLKQWGVFLNQALINYGLEFLASKGYTPLQTPQFMLKDMMAKTAQLEQFDDELYKVVDGEEKNDKYLIATSEQPISALHADEWLQQKELPIRYAGFSSCYRREAGAHGKDAWGIFRVHQFEKIEQFVISDPEKSWEVFDEMINYSEEFYKSLNIPYRVVAIVSGALNNAAAKKYDLEAWFPFQGEYKELVSCSNCTDYQSRNLEIRYGTKAQTDTVKKYVHCLNSTLCATERALCCIMENYQTPEGMNVPEVLRKYIPGAPEFIPFSKGLASNSTSMRRGNPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZS7</accession>
    <name>A0A2T6ZZS7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_673235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZS7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZS7"/>
    <dbReference type="OrthoDB" id="5426838at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
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        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
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        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="825"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="879" mass="98915" checksum="0F9AC8B53412B55E" modified="2018-07-18" version="1">MIKAGEPTPEPPKPAALPKKRYENQIGGPQRMLVPQDPPQTLPANQFPLPPQSVLLQPVQPAHPVINVEDNNVAPIKQQPAYSPPPPPVSAPPSQHQFQEIRQLPRHMPGMRNPILQLPRQQQQEQREQQQREQQQREQQQREQQQREQQQREQQQREQREREQREQEQRQQPQRPQQQHPQQQHPQQQHPQQQHLQQQHPQQRPQHPQQHPQQHSQQHPQQHPQQEHSQPIPQPRHLQQPQPLQPQPPPAPVVVPSHSHPRVPPPPPQPPQQVQQLLVAPIPVQVRGGFIEEIHSGRPERRLEKQPERGHDRTHSAQLESQVVGQVRRQMEMSAEGPMDRHGERQSVGLGKPLERSYMVGSQVGPREVTKQPSRVYERPHDGALERQRDVLLEGQAVGGQPPSGSLIGRPHGVPQERPEKSLQDRSLERSHEGLRTPLQRPPASPHTPVSNTPAPQGKNISPQIPIPKQQGRGPYNQHQPNQPLHHRNRSSPSSIPTFDLQYSQQQPFSQPRAPPAEKPQPSRAPEPLAPPSSRPMSAPSSGQPINPPYKPPPPSHLSSAPQIQRQPSLPPQPAAPPAQSHPPAPAAPSKPRLTSISSLLNPAKEEPPSRPQSRPTPPHHLPPQTPQQQPPPQHAPPPQYASSQLATTQHVAQHPVQHPAQHPPQHPHHGSLQHLQHSQHSQHAPHSHHSQHSGHLQHQQHSQSSIHAPMPRESSRRDVAQYDLHESHQQLSLMAKALSRGGPPSYDSVQAPRGPSSYIPPRESPYTPALRETPYSTPPPHQSRQGLSGPHTPTSHSTLQPPNYTQGHHNHYPPRPQTCSPYPQSGPYPPPSSIPPSQPPHHPPYGQPPQQHPGNCHTPPPQGQYPRGHYEHDRGRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A037</accession>
    <name>A0A2T7A037_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1168408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000051">
        <property type="protein sequence ID" value="PUU81083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A037"/>
    <dbReference type="STRING" id="42251.A0A2T7A037"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="190" mass="20522" checksum="5AC887B4AE29DBB4" modified="2018-07-18" version="1">MTAHDFPSVLIADEGGIDMILVGDSLAMVALGMKDILHYCRAVSRGVRSVVTAPTISRITFVSIPVLSHIGLTLRGSHSLGGFRVQGKPATILAAVLAPVSELITEKLKIPTKGISTSNGGSGQVPAKIDTLGNFPKGRFMPKFVKQYGDVFKESKKAVKQYREDISSRAYPAKEHTLFPPKNSKSLRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0D1</accession>
    <name>A0A2T7A0D1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1077761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0D1"/>
    <dbReference type="STRING" id="42251.A0A2T7A0D1"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="9392" checksum="E049F6DDF727DCF5" modified="2018-07-18" version="1">MHPHLNRTDNDGSCAEVTRILEECHARGFMWKAIGMCNGAKHNLNMCLRAERLERTKKNREAAKDKRKEIVQKWAEIEANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Y0</accession>
    <name>A0A2T7A0Y0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane peroxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_971993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Y0"/>
    <dbReference type="STRING" id="42251.A0A2T7A0Y0"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052816">
        <property type="entry name" value="Peroxisomal_Membrane_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28304:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TECPR1-like DysF" evidence="7">
        <location>
            <begin position="125"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="477" mass="54594" checksum="CE8A0E5FBFCF989B" modified="2018-07-18" version="1">MDDSLTVDYDRYYDRSSSLDDSEQQQEQQQSQRPSSSHASSLPSPLLGLGKNLGFHKPLHSHRRSRSHGSEDDMAAEASGSGGTSPGWQERILSKALQQMLPSDYSLEDYQEPRDKRKEKDRPQFSLALMSGNFRKFNARIGVVFVFQHRLFRLLQWQKPTHTMSALAVYSFVCLDPYLLAVLPVAVVLLFIMVPSFITRHPPPPSMPMEKYTAHGPAIAPPPEVKAVSEMSKDFFRNLRDLQNTMDDFSVAHDKIISLVGPPTNFSDEVVSSAVFIALFILSILLFITAAHLPWRMIFLVTGWIIFSMGHPTLQEILIDAHNTHLLPREVSASTTAGSFIHKDIILDAAPECREVEIFELQKLTSGGEYESWIFSPTPYEPMSAQRIAHERPKGTRFFGDVRCPPGWEWKDKKWTLDLGSTVWVRERYIGGVEIEEEGERWVYDRVEGEQGVRGEWRRRRWVRQVSRKYQMRVGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0Y2</accession>
    <name>A0A2T7A0Y2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1099792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0Y2"/>
    <dbReference type="STRING" id="42251.A0A2T7A0Y2"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015557021" evidence="12">
        <location>
            <begin position="22"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="62"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="393" mass="40767" checksum="9C9683F7259BC712" modified="2018-07-18" version="1">MKINAGLFSLALAGFSALAAAQPHGKHARVHGRHAKALKERDMVYEVTTVWTTILGTPTAQPTSIYVQDNRPSSSPSPTPAPKKDGKKGDKKGNSSSGPSSSISSSTNKGNSGSSNSNTGTSSNTGAGSSTGTDREFPDGVVSCNEFPSDYGALALPWHIPAGWSGLQYQGGNIDAEGVCKEGAYCSYACPPGYSKAQWPADQPASGESIGGLLCKNGKLTLTRSDFKYLCEAGAPGISIKNELSDEVSVCRTDYPGCEGMVIPLQCDPGTEQVLTAPDADTPGAFTWRGGATSAQYYVNNAGVSIKDGCVWGQSTGIVGNWAPYIFGAGKKGNKIWISVSKNPNNSGPANYNVSIVGGTGSCECTMGVCQDNGAGCTVAVDPGQKAYFRLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1S6</accession>
    <name>A0A2T7A1S6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1S6"/>
    <dbReference type="STRING" id="42251.A0A2T7A1S6"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16826" checksum="3E87DA954F7324C7" modified="2018-07-18" version="1">MSSISLKPLFHVPTSPNTSKLLPRIATRNATLLRRPKRPHQFDQLIILTDGSSFKQMTTSPRGVFRTTKDTRNHPLWNESDAAVMGLEEDEAGKLKAFRNKYGHGFDIQDASEIKKELDSDAVGKDATAGSLMDILRYKAGEEDIKGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1Z5</accession>
    <name>A0A2T7A1Z5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KRI1-like family C-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1076714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1Z5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1Z5"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="487"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="622" mass="71858" checksum="8FAE2946757EC4E1" modified="2018-07-18" version="1">MPRPKDKSDPSFQLLSEDLTSSESQHKPKIIFSDSEDSGSGDTQEYHSAVELPDGGDGHKLRINEEYARRFEHNKKREELHRLQEKYSKRDLEGKEEDEEEEDEDEDEEDDTAVLATERLDQEIAATIEAIRKKDPRIYDGKTIFFSAIEEGEADGKEGIESGGEKPMFLKDYHRKNLLSGTAGDEDAPVTYTQEQEDLKRTVVLEMHQAAASEPDSDADDTDAGFLVRKAQPEKLEPIMDIPDPATADPNNPEEYLTRFFQSRAWTKPAGLIPLEDDDSGEEDRIEEFEKAYNFRFEDPDADARGKLITYGRDAISANTVRREEVSGRKKVREKKREKKQAEKELREKEKGRLRKLKTEELMEKFKMIREAAGLGDGGDDEEVEAEVLNNLLEDDWSDEQWEEWMAKRFGNSYYGADVGKIKKPKFDDEIDIGDIVSDLDDDAKPDLENEEEEIGEDAQTAEESKDRRFLQKEGRKKKQKGRDLKRKLERYVEENYDFEDRIPSNSFKTTFRYRETTPESYGLTSLDILAAEDADLNSFVGLKKLASFREPEKKKRDKKRYGKKKRLREWRKETFGDEEGIKMPADWKPTGITEEKESNVDIRGGEGSERKKRRGGIRDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A216</accession>
    <name>A0A2T7A216_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1062352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A216"/>
    <dbReference type="STRING" id="42251.A0A2T7A216"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="135" mass="15644" checksum="A4462F7245AC3DAB" modified="2018-07-18" version="1">MWEVQLHNFGGPNNMRFCPKICHGDSREVPGSRGNKYIDRLRELLEDAREAKDYQTSTVYGQDVPRFHPPSDSSMNATLTGTRIFMHPTLQFLNFLQHRIDSKRVRHFNNETDAIAPPLQKHTEIIKTVPITELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2E5</accession>
    <name>A0A2T7A2E5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1190850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1282" mass="141992" checksum="5DE65115D60CA370" modified="2018-07-18" version="1">MVHSQGFGHRELSSSSRTQLSQFDQACTSVDTAESQILPKPEANLEIGQNDQNWKPWRPLTLRAPTIMASLLITVGLIALIEYVNKISIEEKALFFADEAGNFPVGVVFCYQYLPQMIVVALGVGWAAVDLDVKRLEPYFQLSKPKGATASSSIFLHYPFDFIAFVPINAARKGHWNVFWAGLALCLILWGITPLNSSLLTTQHVTRDIETSFKPLKKLIPFDDQLTSMSSTFLYTSYGVTWLGEKVHSFMTKELIAIPFTPASNGEDRGHLKWGNESWTAQTRVYQTELSCTSSEINAVDGTRYQFSTERCTYVGDFVHLFPDSTRIMVHIGFGYFGGSDLHFLDRKKCEDPNLFLAIWAKARNSHNTSDGFDINALYCKPSYHYQTHEVTVDGIDGSIRKAEPVGERTNFTQKEKIINIIMFESNLGQANTSLGVNSRYFSSRGPDSTLRFKYWGLNSTTPQISYVIGLSPGKKFDDFRDPVTFRNGLDRMHKLLFNNALETLLVDDSGGEEVVGKKVITSKGIVVVPLIAHILAGFLGLVVVCLGGVFLVSYNRQNNLASDPDALGTKMALVAHSETLLRDFNGTDECSAPDLCMEPRIYKLGTWGGGGEYRLDVVGGRDNALVQNPHASCTVPHSGKLVGPVELSVWMGLAATLVNIALLTLLIVLYKSSLRWNGLPMLSDTQLVSQIIFSFIPTVIATLLEPFWALVGRYRALYQPYIELHRGNTSPASSLGLKYTNIPTVLIAPRALRHGHTSLFLASMMVITANILAVAFGGIFNRGSQPLTSDIIVTYPSTTSINTEIQTVVSTKGDPKTFAKDLEDHWLVVNTNVVEGTDLPKWVTDEFYFLPFEWESGDKTGLRTSTTQGYGGNLTCQLLAGNTFQQISHLEEGTWLEINVTMPVSDGDFVRCESVTMMDPLLLKSGTHPFAVEWVYGLEPSNRSDLKAMQGCGSLILAGWGRGEANQSTTANGTNIDIQTDIDMQSNTANQSNTPEETIIDIHTDIDMQSNTTIICSQQISTGLFRVTVDGEGHVKRSKLIGELKYNDLGIFNRSTSVRNFTAQLARLLRAPPGQELNSGVMHNDNSSHSFSQFIGEYLINKNLSDPSTPSPSFEDAQRAISKFYKRFFTILLAQNRNTIFVPASNLRRSEVGQLESIEPRMLMDPVMFYIAVAVLGFQLIAGTIIFASTPRRFLPKFPFNLASEISFFYASSALSDVAGTANMSSAMRSRHLKGLGGTYGYGRFGGSDGERHVGIERMRMIRSYKEAVVTTRQVLPFQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3S4</accession>
    <name>A0A2T7A3S4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1075025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3S4"/>
    <dbReference type="STRING" id="42251.A0A2T7A3S4"/>
    <dbReference type="OrthoDB" id="525520at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="13486" checksum="A0A9E40544406D89" modified="2018-07-18" version="1">MVNLYGVQIAENQLVHKALRSFFGIGHNVADRICAKFSIHKTARISQLTQPKVTAISSEMTKMVIDTELKRKIGDNIMRLKDIGTYRGKRHAQGLPVRGQKTKKQIVSARRFNRVSTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3U0</accession>
    <name>A0A2T7A3U0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1075146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3U0"/>
    <dbReference type="STRING" id="42251.A0A2T7A3U0"/>
    <dbReference type="OrthoDB" id="5152093at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015774202" description="GPI anchored protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="33538" checksum="1FB77359A6D45D10" modified="2018-07-18" version="1">MKVTSLIFLAASATVVAASDEFKPKLINRRDAMPIPGVFMNAVQAAPALRKRQLGEPLELAEAPGKVQKRSLLETRQWGCETVGQINCSFEGCCNQGTVCGTYGGQTGCCPIGKTCTGVGSCKSTETACGTGCCPSNAKCTTNASGSAACDYGLSGSSSSMATSRPTATSSSLSLSSPTPSGSSSGGTCPNGYSPCVGTDSCCPAGVKCLPDKKCDATCSATDVRCGTGCCKDGFTCDTSTSICQEGPGSTNNDDGGSGTILPLSTTTSGSGSGSKTDSPDSGSGSTTLGGSTTQTGVAAGGNGGSGSSSFGTGSSSGVGSSGPRLIFGMGVAGIVAVVGVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4P2</accession>
    <name>A0A2T7A4P2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_346905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4P2"/>
    <dbReference type="OrthoDB" id="5417645at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015737747" evidence="2">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="219" mass="24691" checksum="2A8ADF8297847B44" modified="2018-07-18" version="1">MLSISIFALILALIILISTCLSRRRLYKPHVHPTSSLKASATLAISELTYTIAILIARYCYMSVCLAVPNPRTRSLGPMANEFTTFHIYEGVTQDLVERMIELLRSAHDDLQREEAAVEAFWEQWERTAGHMPRDEVTRGVEMLTEWRDRRRGSVVREVVVEAQKYFGIDDGVVVMEEGLTPQQILDQAMIGATGGEVHDSSRSNGGGSSRRRKKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A527</accession>
    <name>A0A2T7A527_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1074124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A527"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11866" checksum="2EB522EB2FD7BBFA" modified="2018-07-18" version="1">MSLLLYDTMIRWARCDGPNHCRHWRPISGLGRCLVSFVGVECYWRSEYHAVGCSEEEGRGRALVLYKRDKLRIFYIIYYIACVVRLRRRGRVVFCTSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A548</accession>
    <name>A0A2T7A548_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_300501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A548"/>
    <dbReference type="STRING" id="42251.A0A2T7A548"/>
    <dbReference type="OrthoDB" id="10361144at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="344" mass="37671" checksum="18B803AD1A565940" modified="2018-07-18" version="1">MDAPRDSNILEPPEVQEVVMSDRPAELELAQELDGAEKLEEVAMTLDNDGGEVEGGGKGGEESEDGGDRGDRLPSELGGPEIEGEDFESEAGYPGGEIEGSREPKETEIWEDEVGPDQGTEEPEVLAEAQSLARSEGLVGTCNQVKPSRLRIPAAKAFKLSKVPRIPVPTSRVATVKMRKVSVASLKDVPISKMTPHELASTTNTCTAKNKLYSCDFARRVIYKDTPRPPSPNAKAQTLKASQDRARRLAIQEETGIMLGPGDEENFDPNPSSKVRWGHPLESQVDYEERKSPSQVKELLPRPSILSRSAQLNRHGNVVALPTENVIERTKVTISTIRYRGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A580</accession>
    <name>A0A2T7A580_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_302483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A580"/>
    <dbReference type="STRING" id="42251.A0A2T7A580"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU82860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="14411" checksum="E408C6D8501DB5FD" modified="2018-07-18" version="1">MSTEPPPVTCHVLDTSVGKPAANIPCTLSRFLKSEDGSPSSSCFEVARASTNEDGRVAAWEMRQKGVAGKLVLQEGFTYKIRFETWEHFKGETFFPYIEVVFTVKEINQHYHIPLLLSPYAYSTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5F3</accession>
    <name>A0A2T7A5F3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cora-like Mg2+ transporter protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1105475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5F3"/>
    <dbReference type="STRING" id="42251.A0A2T7A5F3"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="70043" checksum="DD3F755357524D83" modified="2018-07-18" version="1">MDHLYTNSSAPLDTNSTPKPSVGSIHQSSQALPQSPPNAEESPGHLPGWKTIGGHQEFYDEEGFLYPSCTLTSEKLKDRKEDDVVIFNYSLSRTDESPPAEGSGPSSGIFGEHDDIFSQVPKDTLIESEQFNQVINPENEPQLIQSRARLSIIDFPQCYDTYDANLLNSMAKELHLPNPATFGHAHSKRVLTLPGRGRFRTGFSLRVPSKSPSELAKSGSPEDKITLFVSFPYFGKSCSSIPLGPECESVKLLDFKRLEGDVPARNAVVSGGGKDATGEILVHQARYMIFDNYTMATFRSKEDSAKDHVPIHRFQERIGAFRAMIQMISNRMDSESWTLGKLQVALCKLEQDIDQMISDEDDQEMERKQKRFQNLLTSLNRLSGGLFAAIAVAERQIAVLQDLHGLFLTSCRTKINDYEKGYPLRQNPFYKNIAPIPILSENSEQIWPNTLDTIDEVVREKRCFITRIEALVENMKIKRKFLSAFLKSGQAETAQEATDAMKRIEDTLKQDQVETLWLGRAVYSFTYIALVFLPLSFLTSYFGMQTVKEFGGSTATMSLSQFWQTAGPVTVGFQLLAMVLVHINKPKQAREKKRRLLREKDLEKGSQTRNFQERALNGSPNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Z8</accession>
    <name>A0A2T7A5Z8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_965569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Z8"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Z8"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="176"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="250" mass="26917" checksum="C067096732B1C154" modified="2018-07-18" version="1">MPTMDGEEKSSTAETSVSPSKTLAAPPAPEPGKASIAGTETDLSGASPAITSSAPAETRSSDRASDEKEPSVREEGLSPPNPIPIAADSKDINTEPIPPPPSSLSPPSTPTTSTTQHKRPSTSEQTPSQTQAQQQQSQPPPSPQTSKRRKTKSKPQEAKESSPTMASDRPRLSEQEKKNNHIASEQKRRMAIREGFDRLTEIVPGLEGQGRSESIVLKKSVDHMRDVLNERQELIRRIKALGGEIPPDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A623</accession>
    <name>A0A2T7A623_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_965423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A623"/>
    <dbReference type="STRING" id="42251.A0A2T7A623"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000502">
        <property type="entry name" value="Actin-Related Proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU83189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="378" mass="42181" checksum="78FA2ACC2FF12A74" modified="2018-07-18" version="1">MALDSLLNQPVVIDNGSGTIKAGFAGEDLPKCFFSSFVGRPKHTRVLAGALEGDVFIGSRAQELRGLLKIKYPLEHGIVTDWDDMERIWQYIYSEELKTLSEEHPVLLTEAPLNPRTNRDTAAQIFFETFNVPALFTSIQAVLSLYASGRTTGIVLDSGDGVSHAVPVYEGFAMPSAIRRIDVAGRDVTENLQVLLRKSGAIFHTSAEKEVVRTMKEKTCYIALDPKKEEKEWAGGGTGRIEEYKLPDGHILKLGSERFRAPEILFDPEIIGLEYPGIHQIVVDAINRTDMDLRMELFGNIVLSGGSTLTKGFGDRLLSEVRRLAVKDMKIKIFAPPERKYSTWIGGSILAGLSTFRKMWVSIDDWHENPEIIHTKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6B8</accession>
    <name>A0A2T7A6B8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6B8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="61" mass="6884" checksum="3B2849EA39607732" modified="2018-07-18" version="1">MPLYTTYTHASITNSRERKAGPLPPRVREHLIHVEVRVYGSLTRRSSGIFSMMGVLLDAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6H9</accession>
    <name>A0A2T7A6H9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin interaction motif protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1098717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000015">
        <property type="protein sequence ID" value="PUU83334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6H9"/>
    <dbReference type="STRING" id="42251.A0A2T7A6H9"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="78343" checksum="5D55F71DDF5AD379" modified="2018-07-18" version="1">METIDSDPELARALAASMEASGAHTGEYGAQETGITGTRTSPATSYLQPANPNREYNPQHWALTTTHEIFLDPGPSERKRRPGDPAFLRPANSGSNIAALLTILHGIPAARESMLARDCLDRDYGHDDQWWNGQPIKILRVTNTGDEEAGEPEITEEVKEVQRLMAFLDGTMRAYGSVESLAMIPSYQEHEQASTLSTFFREWIKAIQKATLEPADGKYGCTFFSEATQYIRGATDEASMNKEVFQIMDLIGPKIGETTLYDMLDSVAFPPDDETDVFVKFAPVICAQIRPFDNGIFNGCPIAIPTVLYPDRYTQAWAVPMREVRREIEEQRNIIAEIELQEDKLKRVQVNEATYHELQGVPQPRELLSILVEHYAAEGNREVPAGIANEAQSESSAVLLAMLEGVIHQLDAKLEALAKKKEEAQETLAKLRSSLTSPENLDPSLPPLTRYTLRGISPESSTTFVLLRSPNSEEGQASASSPAGSIGEQWWCINWTPRASATGWDTTPTLNYEVKKVTEEKVMHAIKTTGEGTVLLVYANDEALNLGEGIDASLPGPLQTFVDRDNAAFKAELQPNSPGRKRHNDWLDPEDEGANSSPGAGFSPKKISSSRSSATLGNATPEISRRNSLSGNEIEMMEGIGSGSSQPPTGGSDGIGERIDFHQSGGGEMQERDGISPVAIAFHLDPKGREKDLDQDMKDVDSEHIEFADSIGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6L0</accession>
    <name>A0A2T7A6L0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_964981</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000014">
        <property type="protein sequence ID" value="PUU83372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6L0"/>
    <dbReference type="STRING" id="42251.A0A2T7A6L0"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU83372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="618" mass="68353" checksum="5714DC730D2F2045" modified="2018-07-18" version="1">MSDNTDLESLPKGGGKEISQFSWKGLTVTVKDSKTQESLDILKGVEGCARPGDMIALMGPSGSGKTTLLNVLARRPAAASASVKGQVHLDNAPLQAKTLREISTYVEQEDALIGSLTVQETIEFAARLSGAERHGGRVSELIRAFGLAKQANTKIGTPVAKGISGGQKRRVSIASQLITRPKILFLDEPTSGLDSKAAYEVMYRIQQVARDENMIVIASIHQPTTATFNLFSQLVLLSAGRLVYSGPTDQVVPYFASHSVPVPPLTNPAEFLLDVCNTDFDNSATDVAGDESRIARLNRLMDAWSPKGSDTEVSSSPFADSEGAMSSSGAPTSVLWQTFVLLQRLWLKSYRDLLAYWIRVIMYLGLAFMMGTVWLRLGRGQDNIQPFINAIFFSGAFMSFMAVAYIPAYLEDHESFRKERANGLYGPTAFLLSNFLIGIPFIFLIAILFSIVTVFLCNFRQTPEHFFRYVMWLFLDLLAAESLVVLISSLIPVFVAALAITAFANGLWMSVGGFLVSPKVLNDFWYYTFYWIDYQRYVFQGMMFNEFEGRVYNCKRVGDECQCMYPTELQDQCKIEGRGVLTALGYGKKDVGLWIGVLIAVIFGMRGLAWVTLKVKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A701</accession>
    <name>A0A2T7A701_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000010">
        <property type="protein sequence ID" value="PUU83523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A701"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="161" mass="17726" checksum="451E7396598D5248" modified="2018-07-18" version="1">MTLASIEILSMVKVGRPSDLHGLVTVQEKEYAFKFTIVDIGKILQLAYLIAEEDWRESLRQQGHDLDRHCAGTARNSRKSTNSQDPQESICMRRRGTIADTSSGWWGKATSYQDRTEGYKASQDAEDVNKSSDVAQNTQNIVDGRKTSLASGGNADISDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A760</accession>
    <name>A0A2T7A760_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1118924</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A760"/>
    <dbReference type="STRING" id="42251.A0A2T7A760"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015692294" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="243"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU83581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="303" mass="32783" checksum="43B62EE16500FB7F" modified="2018-07-18" version="1">MKLPTATILLLATSVAAAKLKPGQKILLSEVPALTLRSDQMTKNRRVPAVSQLKCVGGEGKGKYEIDVMRCKNIGSDYNDEYVSWACTADLPREFKLGSTDVICEGYDSEDDQYVLKGSCGVEYRLALTDYGYEKFGYGGSVFKRLPSKSIETETFLFWAFFFGIVAWILYSVYKNYNNPVPRTRQPQRPGGGGGWFGGGGDDPPPPYDPRPPSKPTFPPSSSQQWRPGFWSGLAAGAAGSYLMGNRDRANQTQTAPQWFQSSGPPSGGYGGPSWGGGGGGGESSSAGSMRHSSTGYGQTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7M3</accession>
    <name>A0A2T7A7M3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1071979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7M3"/>
    <dbReference type="OrthoDB" id="5272818at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="19653" checksum="F9B82FC93C826EC1" modified="2018-07-18" version="1">MTDRPQPAVYLVSGSGPTTVAIAQIELRNVFTFHALWKWILSKQPQYIGKPMVIENRFFVETEIVANDQELPIGSTGFHRIFDDASWDDCKIDLLAHNIPDFPGAANRKPIFSVRVLQPDVDVFDFQNREIVFYSVWKLLNIISSPPPPDEMFQPGGHLLAYLQALGERGQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8D3</accession>
    <name>A0A2T7A8D3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1118532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU84001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8D3"/>
    <dbReference type="STRING" id="42251.A0A2T7A8D3"/>
    <dbReference type="OrthoDB" id="5054768at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015648756" description="Concanavalin A-like lectin/glucanase domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="41935" checksum="F6AD4F97DA1EE86E" modified="2018-07-18" version="1">MRAAFLTFFGIALLGLPQPAHARGGGDSSGGSSSDRSGGDGSSGTGFDFFSPSGDDRSSDCYNVTAGRIGNTTDPFNDIYTNQWLYKFVGSYYNGSVEVEATIDAKDVSCEEQRPVFKEKLDAVLMVGEQLTDLREPNPSPYMFSIVGWKEGTQPGGMPDFETKWVSPDARLMYDSIENARGRSTGTMIPKDADWTVTNQKSGNGYSFEAIFTETADQFVRDSFTILSLNSCNGSQPVDFLMEAIDKPDFLSKDPEGFAQRRTRANGTFDGTSATLSIGGQFDGKFRNWYTRLSDVPSKSKYGTYKLKFSGNLDRSHSHALSTSGQTPSWTKNQDLLPGGSEAVSAAASVASASAACMEGDSAGSRVEVGKAILGLAVLGGLVAAGMGIVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9J9</accession>
    <name>A0A2T7A9J9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial ribosomal protein L27-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1070200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9J9"/>
    <dbReference type="STRING" id="42251.A0A2T7A9J9"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11395" checksum="D6C757CD8071A5AC" modified="2018-07-18" version="1">MQPTSLLHRAIRRLQLTTKQVNGGYYKGTRSGAMGRHTKHGQYIIDWDKVRTYVVPDLAGFQLTPFVTKKMEPTRGEFPGSSPLDGKAYLENWKRVNGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9L8</accession>
    <name>A0A2T6Z9L8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1138810</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000678">
        <property type="protein sequence ID" value="PUU72190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9L8"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9L8"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="254"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="318"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU72190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="530" mass="59921" checksum="BE7E3C7F10D8C423" modified="2018-07-18" version="1">MDLDTVQLPISAGKTPIATVLCATCGAPIDGSTGVAMCYDCIKLNVDISDGIQREATTHFCRGCDRWLQPPSQWVSAAPESRELLALCLRKLRGLAKVRIIDASFIWTEPHSKRIKVKITVQQEAFQSTILQQSFEVGYVVAYHQCPDCAKSFTANTWRACVQVRQKVPHKRTFLYLEQLILKHNAHKDTINIREVKDGLDFYYSQRNQATKMVDFLGAVVPITTKKSSELISTDIHTSTKSYKFTYSVELVPICKDDLVCIPIKMARSLGNISPLLLCTRIGNSIHLMDPNTLQVTDVQTSVYWRAPFSSLADVHELVEFIVLDIEPLGPTHGRFILADAQVARASDMVSNTQSYLVRTHLGGILHPGDSVLGYHLSGANFNNPQHEELERTAPGQIPEVILVKKSYPRKKKSKSRNWRLRRMAREESDMLPRKQDQERAERDYEMFLRDVEEDTELRASLALYKNTRKNPPKTQRMEGVEMESVTEERAPPGSGTEQDTEDDDGDDSDLPEIAVDELLDEFEEMHVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9P1</accession>
    <name>A0A2T6Z9P1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1069942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000657">
        <property type="protein sequence ID" value="PUU72208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9P1"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9P1"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="403"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="702"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="871" mass="99285" checksum="9C7592579FC5922D" modified="2018-07-18" version="1">MSSSKLPRKFTPPSSPTASYYDISDDDENGYSTITNTRTGRALVQQKPPPSDGPSTPPAVATTLLLAWLPESALGDAYDTYVKVDLIDAETPPRQSYLVPPPPATVYAPGTSCVGNYAFAVPVSEIYSLLIRPPNLGWWWGSVVINTRAGDSFPALFFHDSECASTIAQSKKRVRASFDPFGEGGGLFWGGDEVLRWLRRYVRVEKSEVEPSVYLVEPSQEDLLSFGSKPTIVGHVGESSASGGAGMDPLTKMFKEARWGFLEKVSRVTRFTRRTAEDILDSPKVPLQVRRLLKNPDVVNLQDEFDSARLYLARWAMGIAEQSERERQQDHQVVWASRDALELVDSAVGEFEILDLESGSTKLDSDKRKPVSLEEWNRWFDPKTGKLAITANEAKERIFHGGVEPGAARKEVWLWLLDVYPWDSTKDERIALMNSKRDEYVRLKGKWWDDLDRRNNDEYWRDQKNRIEKDVHRTDRGVPIFAGEDIPHPDPDSPFAETGTNVHLEQMKDMLLTYNEYNTDLGYVQGMSDLLAPIYAVLQDDAAAFWAFVGFMERMERNFLRDQTGMRAQLVALDHLVQLMDPKLYAHLESADSTNFFFFFRMLLVWYKREFKWDDVLRLWETMWTNFLSSQFHLFIALAILERHRDVIMDHLKQFDEVLKYINELSTTIELSSTRVRAEALFYKFQRTVEAADRKSGFVAPGEGSSTMRRRRTENACEGDPPNSPGALTPRAVANKGKNIEGRNGEILPNISPELRTLLNRDIIRAKVRLGWVMKIYGCSSNMDEIIVFFLFLLRSITRKAVLVMIVHKATRVTPSHLGLLEALYYATFPFNKCHWYPDTPGSLRVCTPTTHTSTTDDWVAEFSKDIARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9R5</accession>
    <name>A0A2T6Z9R5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PUA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1138433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000622">
        <property type="protein sequence ID" value="PUU72240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9R5"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9R5"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="237"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU72240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="423" mass="47636" checksum="029DEA459AD7FF97" modified="2018-07-18" version="1">MADHHERIERVRDLRFKKILKNLRPSAAAGASGTAGPSTGRNTTATNRGAQAEFEDNENYDEVGPGLKDEAAARLLQRRIKRNPVVASNRISEKTRFSSNRVISRSDLIALSVHADTISRVLKKPSPNAADWQTVREALYKLPFENVDQKIVHSSGAMKQLLRIEQDRFDIPEDISLDAQMILKRWRNGDYDPHLLRGIDLNQTITHVKGKGGKNVKRTRHYKLEEDYDWKRDDNVEGNHELFVGEWWPLQICALRDGAHGEMEAGISGNTIIGAISVIVSGGALYPDLDELDRVLYCGTMGIEAPINYAADPAEERDPGDRIPSHNTKLLMISYKNGTKIRLFRSAKSQSPYAPAEGLRYDGLYTIRAYEILDKKNAVYRFELIRESNQPAIRGDPDDPGCKPNKVELAKWQGIKKTLKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9X1</accession>
    <name>A0A2T6Z9X1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1104439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000604">
        <property type="protein sequence ID" value="PUU72283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9X1"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9X1"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="436" mass="46189" checksum="473AE39443FD3E3B" modified="2018-07-18" version="1">MDQRGWVLVCASGGACVLGSSIICLDALLRRLPFRRFRNFSIRESSTFLAASLSLSFGVMFFSALYGMLPKAKEYLLTSGLTPTTANAILMIAFLGGVGGLQLVSELLHYCLPSSIVNCDEHGRVSTRGRGRGGDRGEGRGRRDERAPLLGRQVSVVSKISVSVSNLVRGCVGGAEGKCYGFSDHDCEQKCAGERVSVPGSSGSESPSHRDGEEVSINGDLERGYQSISHEAAPIHHEPHHHSHPHSHSELRRSRSPASITIPPDGEVGSSAPGHHHVVDNQFLSIGVQTSIAIAIHKIPEGFITYATNHANPTLALPLFLAIFIHNITEGFAMSLPLYLALKSRTYAILWASLLGGLSQPVGAGIAALGMRHGGGKVIGHEWGYGILFAVTSGVMCSVGLQLFSQAAGLHHGGRVPFVWAFLGMGVVGVSFGVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9Y0</accession>
    <name>A0A2T6Z9Y0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000620">
        <property type="protein sequence ID" value="PUU72246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9Y0"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9Y0"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="525" mass="55999" checksum="B8828EF570F3FCDA" modified="2018-07-18" version="1">MSMDAGGLAQINYFHQQANPTSFASRGKGSHLRNISVPVPSNNLSAPADNQTATTPRTARSALLAGLRTAPRTPNPSPASASLTDSGLESKYSSPGSSGFVPQNTRSGQSPNRYRGYQSSQGTPYSAASQQLPTPPSSSSPALGLNGEMFELSDETDNEKYQQLLATNFILAQKQAELQAQLANSVAAHQVQLLQLQQLQLQSSGSSNFATPPMSPGGLGSYMQQSANAANMNANRYYPIYNNIYGYYAQPQVSVDYLQQFQQQQQQSPPASAQPENNAPVYQPPQQQQQQQQQTQSQERQSPTLNASTGRSGRSRSPPKLTLNQPTNSSGFKRGHRKASSLSTCVNVSNLDIAEPPKTSLPKIMPTTPMTATFAPGHASGSHPIRQPRGPPAFEELKAKPTNKDGGSKNFATRQRRRAVFKLVTAGMERRTARSASSSIGGTMTPVSENEGFGFEDAESVSSSLSGRASRTSIRGGESPQDYSASSVSGDEGVSVKQTGSKESGGLKAPRLVFSSATKRNSAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAF8</accession>
    <name>A0A2T6ZAF8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1097239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="NESQ01000532">
        <property type="protein sequence ID" value="PUU72453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAF8"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="20983" checksum="7E736B9172B0C60C" modified="2018-07-18" version="1">MFSGTKGPGEAEAMDGTNLRVLIVHARWNTSLVTPLVEGARKKLQERGVKASNIITQSVPGSWELPIAVQRLYSASQVQASSAPSGDLLGGLGRSSTPVPGASSSSKGTFDAIIAIGVLIKGDTAHFEHIAESVSRGLMRVQLDFGVPVIFGLLTVLNEEQARKRAGLTFDGYNHGEDWGDAAAEMGAKRKLWADGVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBI0</accession>
    <name>A0A2T6ZBI0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_911847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000453">
        <property type="protein sequence ID" value="PUU72858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBI0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBI0"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant" evidence="6">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="12038" checksum="F03AC6990CED08E5" modified="2018-07-18" version="1" fragment="single">VQTHDGGKTTLTAILAKASKGIVIFAYPKASTTECTTQACLFRDNYTAFTDAGYSVYGLSGDQPGANEKFRNKQNLTYTLLCDPTYELHEKLGIKKSPKGTIRSVIIIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBL1</accession>
    <name>A0A2T6ZBL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1136435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000447">
        <property type="protein sequence ID" value="PUU72882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBL1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="271" mass="31903" checksum="3A00EF4A1BD66E7A" modified="2018-07-18" version="1">MPIHWYTRCKVFAVKPRSTSLGCRIRYKSKTSAQHPKPTTNDARWSGSDKLPEDGKLWAKLVYDLQRACEREKVERHRHDQAEFLKEKQNMINQLHEQKENYKYLEQRLNNEIARLVQENRALKAARDKIDDKFKKYHQNFEIRGALEHIIQEAETQEKILPNKTKQTSLNLLAEHADIMAILLPECKARSLDPARVKGQIWFLYAMYSAYAHGHDNDLLITVDHPPFRRAALVVLLKLQDNWNHPVKWSEEKISPPMPPSHQQMLQENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBW4</accession>
    <name>A0A2T6ZBW4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1096122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000436">
        <property type="protein sequence ID" value="PUU72973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBW4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="197" mass="21663" checksum="CA4778216AFA4660" modified="2018-07-18" version="1">MRSRSPFTTAFYAIPSVHRQKYIPIQAFSMALQSVLKGESICLIFFVLGVYRVLTLKPDSQSVKYAIAKPFYDGVLCDPICPPPKGRLHTSIFHGATESSEGGSLCRVFLVLGVYSVLTLKPDSQSVKHAIMKPFYDGPFCNVVLRHPICPPPKGRLHTSILHGATESSEGGVIMPGFFSPGWLESAHFNNSSYVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC75</accession>
    <name>A0A2T6ZC75_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Folate-sensitive fragile site protein Fra10Ac1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000413">
        <property type="protein sequence ID" value="PUU73098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC75"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC75"/>
    <dbReference type="OrthoDB" id="197967at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019129">
        <property type="entry name" value="Folate-sensitive_fs_Fra10Ac1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF25">
        <property type="entry name" value="PROTEIN FRA10AC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09725">
        <property type="entry name" value="Fra10Ac1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="237" mass="27833" checksum="3FC4B57BE3C57500" modified="2018-07-18" version="1">MPPTSRTFAQSSGAASAYARHLQAASAYVSYYGGTVPTPAKYKSERDILEDHHQFIRTDEETDTEEKRIAKSYYDKLFKEFAMIELARWREKQIAMRWRTKQEVLDGKGQFSCANLSCRNHRCTLDENPDEGGGLRSVELNFEYVEHGEKKHALVTARVCEECADKLRYVQRGGKERRKRSRRSRSPSRGRHQRRRSEGAEESRPRSESLRGRRRKLDSSMRRDDSRLRRRRHHERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCD3</accession>
    <name>A0A2T6ZCD3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1005862</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000409">
        <property type="protein sequence ID" value="PUU73155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCD3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCD3"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.640">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="15">
        <location>
            <begin position="82"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Cysteinyl-tRNA synthetase class Ia DALR" evidence="16">
        <location>
            <begin position="609"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU73155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="854" mass="95978" checksum="0F4AE1A0CF9D826F" modified="2018-07-18" version="1">MLFIFPHHHLRLRAISSLRPKFTAITTHQLKAYSPFTMASTSRREQPAWTPPSPHGAPLPPLRIYNSLTKEKNLFVPIDPSGREITWYCCGPTVYDAGHLGHARNYVTTDVLRRILRDYFGFKVRFVQNVTDVDDKIILRARQQHLLEEFISQNSSITPEVASTVSGAWAAYLKKNTAADDDVTPQSFENWATSTQKEIMSLVLKERERKLNPSAKVEEEEEVILDEKSTKLKMHLTTLHTASLVLQKIPEDSKDFWSATSSILLPYLDSLNQGREYPPVVFSKLTSYWENHFNEDMATLNVLPPTTVTRVSEFIPENVAFVKKLVDKGFAYPTADGSVYFDIAAYEAAGHHYAKLQPWNRGDESLIADGEGALTSDKSTTLPNTVETGEEGKQKLLASKKTPQDFALWKAFKAEKPGEPSWDSPWGKGRPGWHIECSVMCSEVLGGQVDIHSGGIDLAFPHHDNEIAQSEAYWDGCCDIPKTADGKHQWINYFLHMGHLSIHGSKMSKSLKNFVSIRDALTRGGWTPRSLRIVFLLGGWKEGIEVREGVLMEAKSWETTVAKFFSNVKALIAEEEEKEKKGNRAMQPFGPLEHAINKDFKTADQNLHAALCDNFNTPSAMKVLTDLIGSTNKYMSQTKSLAAVKEIARWITRIVTIFGLDSTGTLNDSDRIGWADSTATSSTGAEGMAYLRILSEFRDSVRALAISSPKDAISKDLLLRCDRLRDHDLANLGVVLDDRDSANGAPALIRLVPAEELIAAREEKERRAAEKERKKEEARLKKEEEERKKEELAKVSHLELFKTDDYSEWDEQGIPTKDKEGVEITKSGRKTLVKGWERQKKLHEAWLKAKGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCE1</accession>
    <name>A0A2T6ZCE1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000408">
        <property type="protein sequence ID" value="PUU73167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCE1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCE1"/>
    <dbReference type="OrthoDB" id="5462258at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17035" checksum="EBE013108A38D882" modified="2018-07-18" version="1">MTTFPSSKGGSSHAQQSEPSNTGAGLASFTSIQVKPSIKFTGFTGEIQKHGPVLPVQNHLRGLTKAEMALAVVEMLNLHQQHSEVLGVVVTHIWEYYIVPGKLWEHYEGGKSQFMEDVAFSEFVGPTIKSSKATQSRKLRNIASLQAAWGVRWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCR0</accession>
    <name>A0A2T6ZCR0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Inhibitor of apoptosis-promoting Bax1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1095408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000392">
        <property type="protein sequence ID" value="PUU73278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCR0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCR0"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="337" mass="36593" checksum="A14840BA818ED08D" modified="2018-07-18" version="1">MFLQTAIRPVARRALLPSSSSSAKTLTRTFTALRSPVLRQTLTPVRHHQKFPLKTQFATGKRFFTTDPAIVARPTRQQSIQKLLYAGGIFGGSLLAINLLFNNESREDSIPLYERAYLQETFTYTGLGVGMMGLAAKGLHNMGWSYKLMSMNPWVVLGGGLVTAVGTLVATRATDPDNYIQKHLLWSAFNLSNAAVLAPLFFYSPAILARAGLYTVGVIGSIAFVGATAKEDKYLYLGGPLLAGVAVVALSSLGPMVLPLGSRALVASEAISLYGGLAVFGGLTLYDVQKIMHNARLADKGLIKKDTVNESISLELDFINIFIRIVQILGQQQQNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCV5</accession>
    <name>A0A2T6ZCV5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000387">
        <property type="protein sequence ID" value="PUU73331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCV5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="155" mass="17251" checksum="E3D660A976D9C370" modified="2018-07-18" version="1">MNPTAQYYTATARIEGPGYVREHNSRAPSTMTPLRDQGQAGASIGRRNFTDLPATLQEVESFTPIELVNWLESVNYFSIYGEGGKILRGKIMEYWISGADLCRNGHNPQWLEHCLPGAPSDRLASFVRGLYHVSGMPIPLEQDTLLDANPQRTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCW4</accession>
    <name>A0A2T6ZCW4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1135440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000391">
        <property type="protein sequence ID" value="PUU73286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZCW4"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="678"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="886"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU73286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1355" mass="154442" checksum="AD85D11DB49A989C" modified="2018-07-18" version="1">MSHRQRRTGLGGSQRSRHSVLVTADDAYTYALRCAYLAYLLQPRPRRQVPAPPPPQIHRSSTSFHELMRDFSSHTSRGSKGNKFPKGFLPALQPRLEGVVMGREPGAEYKDAAVKRTFGAFYAAFREPRFYEGVVKSRRAEDLVLIFYSSATKELQKVKQDDSWKWLSDRHVALFVRLMHSVIKDKDWVGSNPELASQLATLESKLLQHDQNLAEETRRTSTAMVSAPPAPLSYNVNDMPLVKVVARTFGVSLQTCQQDINANRSAWTEKAALMDMKAYSNNLSLGNTRRTLRSDDFDTDEAWEAWRKLETPALSQIMLGIVQSNPSELAKTTSGPSPITARPQSLQQNSPYPYHDLSRSSTSSDASSSMYGFDHPVDMGNFDVSSPAADDTLDTPYTYIPPDPRIYFRHVVEKCLSCDLRDPDTLPMDIPGADPTVLLSKNSLDLLNECCTRWRIPQFSRSILFLDAVRKFYQDQDIDLVTLDAAWLYAKGATDFDWRTWTIADQNLYRQILSSIHDNLLRDLYDLLQHAFDPKSKPVGRVMYILNEHIYEDPLFTSGNLESYIEQLKEGLRSRASEVLKEIVSELPQDRNELDPFHLVELTQKIIKLAEKISKRFKEPIMGHRSNMGIHLTRSVDPMMIFVEVVFPEYAAVARDVVLEIMQAYQEKNQEVEIEDGFDLYRELSEIRRIYGDAFPKNKFAIHLEDFLADFVWRWIKNTDAKVIGWVDEAIKHDDFIIRIREEQGREPTDDERHTMSVVDIFRSLNQTVDYIKKLEWKDEVQYGKFMTALAKTLGSGVARYCEVLEKLFTFEMDKQTPEQEAAARQTRQQRWMAMARDAWSNKDKIEPFQFAPESCTKLNNIEFALQQLDKLEHTVDVDGVAATLTRHAPPVTQQRKKASNYVFTIKIVEAEDLKAMDINGFSDPYVVLGDEYQKRLAKTRVIYSNLNPRWEETVDITTQGQIWLTATVWDWDTVGDHDCVGRTSIKLDPSNFGDFLPKEYWLDLDTQGRLLLRVSMEGERDDIQFYFGRAFRTLKRTERDMTRQITDKLSAYIHHCLSRSALKSVLSKGYSISAVSSLFSRTGLGGNRPPSTSGHGVTEAEIAAAVVPLTDYFNENFAILNQTLTNAALTLVMSKLWKEVLVTIEGLLVPTLSDKPSQQKQLSPQETETVFKWLQLMFDFFHAVDEHTGEATGVPIDVLKSPKYHELQSLNFFYFESTDNLIRTSERMANASAARQQQARQKLIEKNNPAPTSFGGFLGVPGAKRTKSVLMSRNLGTMRKAKEEKRREAQAEPNDDMILRILRMRPEAASYLKDRNRQKERLAAAAAAEAIVRQSMSSGGGRMGTMVPGGPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDF9</accession>
    <name>A0A2T6ZDF9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000369">
        <property type="protein sequence ID" value="PUU73531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDF9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="210" mass="23422" checksum="111FFE0202CE7832" modified="2018-07-18" version="1">MVLPHPLAVPNLLVIPAITPSHSELTTPELEGGGGERTSSGWNMAVGLELSILAKACSLIWDWTIFINPFLDPIALTKEVRRCWSDGKRELGFLNFINATQPQITSMREVWHGQIIEQIRTILKNRIKKEQGKHIERMEGYSNDEDALRWEFGIDLEADELEAAGSLTDVARGHGRCPPQWDQGGNLGVSDDAALLREPVDTPFQVEETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDG9</accession>
    <name>A0A2T6ZDG9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hamartin protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1068925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000370">
        <property type="protein sequence ID" value="PUU73523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDG9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDG9"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="924"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="798"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="924"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1046"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1131" mass="126434" checksum="E2DD0C9CF27A553E" modified="2018-07-18" version="1">MSGGSLKDLSKTLNVALSAPLPLYPLPDDVLNVIHAYLNKHINSDDHDSQRLHDELLSLHESKVRNRPEKHATFLACFRALRPGLIGVERLLKWWDTLVRPTLDSMGQAKVVVADARAIVLSVLAYDDEDDPTGEKAKASAVFTDKLFEVFLEKTKLISSDRGAGFKEEQRQRFVSANVEAVLLAFGKRKPKVFLEKIDSYVVQKEYRLQVLGLLCSFVRLQGPHLYQILQTELLDHLLQCLENDTSTTVISLALTVLIMFMPHLCNSLASYLPRLFVVYTRVLCWDKFGVVRLEEMKFSGNKDNYSRASTPLPLAGGESCSSSWQKLDSSFETATSTTPDVSDYFTFLYGLYPLNLMAFIREPYKFLERANHKDIDHLDIDEETIRQRTETYRQRHTLHPNFLNLTVETELSDQSRWMKVEPADVTAECIGLVNSSIPVGSAHDTRAKGAAPAAPTKPELPEALVPTEDIPNESLLSSEAVDDDYASNYSSDTPARSWKGDTTATHPNNNYTEVLGLFSRPPVGHGAHSKDSPHTIPRDSKTPDSPTIPHTIALGDEEERLQDMIRLQENLRANLHESMRNDSTHSLPPLPGPPPSGPPPGYGSVTASPRLDAYVHSLSQNTVPRSPALRPAASDTQGTIAFLQREVMLLKNDLNFERYLKQQHLSHIGHLQRKHIKEATAEAETQNLINTNKTLKAKLEEAKKAYTASRQEALKSKSQAKKWEAELNFKIRSLREEQKAWKNDEELTKQALQAAKAEADHLRKLLAENEAEGLRSRQKLQSISSEMEEVNKLRAFVDHLSSKLAQHESRSEDLEMRKHSEEAALAQVERIKMRLQSQEQEAQKMKHGYDNKVQELESRISSLSNPMPAAPSQALQGMIDNALSATNARLASLKKEHNQLLSRYYNLKIKCIKLQADQELSNLPPQHSSLDNHQTSPTSQGYNDVHSSLALSDSEGSQYHSPRGGNHLYHSEGSTSPHSGSYPESAKSNYSGGQNMYFSHNDRTQSAPNSAMHTVSPGYISPGPATATGGGQFSMGFSSPEPHQHPSYQQQHQQNHPGQQQQNQPNKQQQPAQEHPNPLPLRRRPSIVGSTFSSTDSQSMKTVTSTTSSEKRRQEKIKANSEVRVRGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDI6</accession>
    <name>A0A2T6ZDI6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1134971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000368">
        <property type="protein sequence ID" value="PUU73552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDI6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDI6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="147" mass="15848" checksum="F59FF50543E6FFBE" modified="2018-07-18" version="1">MNWVYLETAPPKFPPRAGNGYRERSDGIASTNSNLRYATPLEVSNTKIGATGDAGKPIHRSFLENVAAGYMQRLDGHNGSGAVSRDTKHMLPHFPFCCANVPGITDSNISVITPEWDILLIDSSQSGKQNGLWMPVESDGKVSSSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDL1</accession>
    <name>A0A2T6ZDL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1004090</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000366">
        <property type="protein sequence ID" value="PUU73580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDL1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDL1"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="35"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="258"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="514"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU73580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="787" mass="87307" checksum="3A352FF207AF882B" modified="2018-07-18" version="1">MSAKRKLDPAVGEEELIDESDHLTFLCLGGGNEVGRSCHILRYKGKTVMLDAGVHPAYEGLAGLPFYDQFDLSAVDVLLISHFHLDHAASLPYVMTKTNFRGRVFMTHPTKAIYKWLIQDSVRVGNVHNSPDNLYTEADHLSSYSRIEAIDYHTTLTHAGISITPYHAGHVLGGAMFFIEIAGLKILFTGDYSREDDRHLVSAEVPHQKPDLLICESTYGTATHMPRLEKEARLMKMTTEILNRGGRVLMPVFALGRAQELLLILDEYWEKHPAYQSYPIYYASNLARKCMDVYRTYINTMNDKIKRAMFEGEGRNPWDFRWVRSLKTIDRFEDVGGCVMLASPGMLQNGVSRELLERWCPDPRNGLVITGYSVEGTMAKQIMNEPTEIPAVVTANRSGSTANRGVDGQVMVPRRCSVEELSFAAHVDYAQNSGFIEEVGAKVVILVHGEQNNMGRLKSALLSKNSDRKDKDKVKIYNPKNCEELRIPFKADKIAKVVGKLAQKPPGTQTLALKEQLLTGVLVQNDFKLSLMTPDDLREYAGLTTTVVSCRQKIPMRAAGVGLVRWSLDNMFGAVVDEGVKYKSGNTFKIMDTVTVRCRKGYVELEWVGNMLNDGIADATAAVLMGLETSPAAVRHSSTTHTHAHSSDLSEIPETSPHAHIRHSDRIERVLTFLEAQFGDCVTPLPPGSQPASSPAALPPKSIAEATTTATAITDAGAPDEEMDVVQEMREVVPGVQIKIDNNIVANVWFENLDVECRNESLKMRVKTVVERAVETVAPFVDLLGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEI7</accession>
    <name>A0A2T6ZEI7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000334">
        <property type="protein sequence ID" value="PUU73917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEI7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEI7"/>
    <dbReference type="OrthoDB" id="14612at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl phosphate synthase ATP-binding" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="933" mass="105363" checksum="7EEB00B51C947F05" modified="2018-07-18" version="1">MMATPEDLQANADYICMADQYVEVPGELIVDAAERMGVHAVGAGWLGYKISSTIIAQHAEVPCIPWSRLGVREVQIDSEGLVTIAGDVYAKGCTHLAEDALQKALEIGFSVMIKASESGGGKGIRKVQLLADKYGNNISLFGRNCSVHRRHQKIIEEAPVTVANQTTFSRIEKAAVRLGKLVRYVSASSIEYLYSHSDDKFYFLELNPSLQVEHPTTEMVTSLSAPLEIVGTKPPQRFTLLTTVLKNIIDGYNNQAIMATSLKELIQVLRDPKLPYREWKLDPIFSQVIERSKSRKGESPAKQLRKTLDKFLEENIAAGDIELLKFALLPLTEIMDRYSKGLKVYELSVPLGLMEQYWSIEKLFSGQNTCDEDIILRLHDENRDDINNVVQAVLFHSKIASKNNLILAILEEYRPNKPNNGSIIKFFRPILKKLTKLESQRAAQIEHILRSSVVESQYGETGWGKEVIDSKYTVFDVLPIFFAHADSWISLAALEVYVRQAYRAYELHAINYHNLNSEPPFIVTWDYQLKKIGTTEYGMTQPSALATSTVERGDRFKHVGSISDLSFLVRKSGIEPVRKGVIIPITFLDEAEEYHVCALELIPLGKGAKRSMPLSVLETEEEEDSLPAVCNVAVRDAKSMDDKDHLERILPLVADHKDELLSRTVRRINFICRHRDGSYPGYFTFRGPEYREEQSIRHIEPALAFQLELGRLSNFTIKPVFTENGNIQVYEVYDEIPTADYLISETDRLINDILDALEMIGNNNSDLNHIFINFTPVSPLSPEEIEPARGGCIEHFGRLVIICTDPKSGLAYPLCVIIQNASGYVIQVEMYTERKTDKGQWPKRHKAHLMGTQYVDDFPELFRQAFHQSWLKSAKKVPSFKERIPPLTECLEYSELVLDDNGGLAEVQRELGTNAHGMVGWVLTAKTPEHPFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFW4</accession>
    <name>A0A2T6ZFW4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-related protein RSR1</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_455472</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000304">
        <property type="protein sequence ID" value="PUU74375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFW4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFW4"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000114">
        <property type="term" value="P:regulation of establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000631">
        <property type="entry name" value="Ras small monomeric GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU74375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="205" mass="23022" checksum="2C837154D82E6882" modified="2018-07-18" version="1">MQHRREYHIVILGAGGVGKSCLTSQFVHNEWIEYYDPTIEDVYRKVIDVDGRSCILEILDTAGTEQFTAMREIYMKAGQGFLLVYSITSLSTLTELSDLRDQILRIKEADSVPLVIVGNKSDLEEDRAVRRDRAIMLSQKWGRVPFYETSARKRQNVDEVFLDLCRQMMRADVGGSGSGGGAGGGGPSEKVAQTPRKKRRFCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFZ9</accession>
    <name>A0A2T6ZFZ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1068268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000305">
        <property type="protein sequence ID" value="PUU74344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFZ9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="153" mass="17609" checksum="E8188B99A8E7CE31" modified="2018-07-18" version="1">MTDHMITNTPEDITVELSSEVPTVFNVTSGKLTLKHREQAAEIELHRREISSRKIFLIDEITRINQRLDLVAEEVIGLLVQELVCLAEAIEQVRQRATRHERVNTQLWANIGQTEEESFSQDTMLDKALKETQMKFEAEIATARKELCMMDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG87</accession>
    <name>A0A2T6ZG87_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1133217</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000296">
        <property type="protein sequence ID" value="PUU74503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG87"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG87"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="148"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU74503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="379" mass="41857" checksum="A3E990732B988206" modified="2018-07-18" version="1">MTVLEISQRLASLTDTHKECMSLISRLSKLDTPNSDGARIELANVIHQSLRDAESELELLSAQVEDEVGDGAQVALKSKVEKAGEDLKIARLQYRKAQLSAKRNALAAEQREREALLGGSGRSTPDSITGKRKGNQKLSQDDLLLHASTDVTTALRRTHTLLQSELSRSQFAAETLNSSTAALQDLTHLYSAFDDVISSSRALITDLVRKNKSDKWYYEKAIQILLGLLVWLVIRRLLWGPIYLLLVVPFRITWWGLSLVAGGLGVGRTREISEGAGVGMGGGATMVQVVGIPESMLEKKSPEERATPVSGEGKGEKSMREQVEGIIDGELEVELEVEKVEMESAEPVDKNPKARNMEYDSEEERQAWEKGRPETHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGG6</accession>
    <name>A0A2T6ZGG6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1092482</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="NESQ01000291">
        <property type="protein sequence ID" value="PUU74569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGG6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGG6"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="132"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="31526" checksum="F55B26D6DF96A1BB" modified="2018-07-18" version="1">MLLLIRKVPLAALGRRLGVIRFTSTISTRHSNTITPPLPPPQEAPQLPGGSFVVPPPVATSSYPLARLPTTSLLRSMLLHSITASPILYKLGTKLLMMNLDSLKERSLMKWGVDKTFYTQFCAGSTPAEIATTISELRSLGLGVILAYAREAEISDTAGLSESQSQQIEQWLSGSLKTIACVEPGDFVAIKYSGAGLSSLPLLSRRAPCDESRGVGAALHEICKSAMAKGVRILIDAEQAGVQDGVHDWTLELMRRYNRGNDTKAVVYNTYQMSDYYYYYFLGMGYHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGK7</accession>
    <name>A0A2T6ZGK7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1092576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000293">
        <property type="protein sequence ID" value="PUU74544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGK7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGK7"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="299" mass="34318" checksum="B38C56A193ABD4AF" modified="2018-07-18" version="1">MTTTVNNTPKVWTTLLTNTKYLPGLLALDFSLKSVGSKYPLVVLYTDTLESEGHEALKLRNIPTKRIEYLLPSVHKDYKNDVRFYDCWSKLQPFSLVEYERVVQLDSDMILRKNMDELMDLALDIEGDRVFAASHACVCNPLKKAHYPKDWIPSNCAYTSQHSTPEKALETGAPSTIGLGICNGGLQVVQPSQKLYDQIVKTLDSPDATENYEFADQSLLSDTFRGRWVPLSYIYNALKTIRSCHKEIWNDDEVKNVHYVLSPKPWDDRESEDFTHKWWWECNDARVAKEKEAGISDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGP6</accession>
    <name>A0A2T6ZGP6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase assembly protein CtaG/Cox11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1032646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000283">
        <property type="protein sequence ID" value="PUU74655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGP6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZGP6"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005413">
        <property type="entry name" value="COX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="19921" checksum="A82E1DCD4973F74D" modified="2018-07-18" version="1">MSLGIATLTLAYASVPLYRAICQRTGFGGTPITDQARFTPEKLVPVTDARRLRITFSASVSDVLEWKFTPQQREVRVLPGETALAFYKAKNCSKEDIIGVATYSVTPGQVAPYFSKIQCFCFEEQKLNAGEEVDMPVFFFIDPDFLDDPQMRGIDTVTLSYTFFKAKYDSKGNLRPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGU6</accession>
    <name>A0A2T6ZGU6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_413778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000279">
        <property type="protein sequence ID" value="PUU74707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGU6"/>
    <dbReference type="OrthoDB" id="10388264at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="439" mass="49696" checksum="9683F9ACF5C08C9E" modified="2018-07-18" version="1">MHFDWEPLSRSCRNMSAETSLPSTPLTLSKGRRQRGRAGSVTNPFPPVPPHPPPNSPFEPAPISHTSSSSPQPPPPTPEPPPQNIREDGYIYLQVEIGFDRQLPAPWANRREPASHFCLMPRPENIGRKYFLPGPHRHCEKYYTSCDHRSYESFVMYNMSAVHGVVASFVVVVPLLLETRPCRTLNLIEDAIRRAFPQTDNLENYNEINARIGVETTSQRICTLRQLRRVFMALVLFGERMVELGAFALKAPFLETPFVEFEPWEVGYEFMVHLDGCYEVGRILEFFQEGGMGGGLPLGKYWQVTGSLSRSGSLDLICYTTYVQYAVIRATLERCVMFLWTAMHTPAERYMAWARCGVSQLELDRFGCGHYGQVNANDLEPNRGWKVEDDAAMEWEEEEEVTSEYLPEDGDGGEDDYDFGDCRVTFAEGEGTELAGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHD9</accession>
    <name>A0A2T6ZHD9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">UDP-glucose:Glyco protein glucosyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1091487</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000262">
        <property type="protein sequence ID" value="PUU74889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZHD9"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015654930" evidence="10">
        <location>
            <begin position="27"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="41"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="280"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="417"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="674"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1227"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1498"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1500"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU74889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1533" mass="173086" checksum="6180CF1A3C360884" modified="2018-07-18" version="1">MRLPNFGGRLSVGLLLLSPCVRLVSCGPAVNVALKASWNGAPFLLELLETAAEEVGASYFPLLDRIAAGDFADIGSDKALYDAFLRVAREEGFLVGQEELASFNFALSIHAAAPRIEAHYHYYVNSLEPIMGRLYDATCGVWLQWSHKQVCDTGGDFEDMLNSWERYRNDRRRLQFDRVLETQEDKPAAILYADIEAPNFKRFHQVLRDYAKQGILTYRVRYKPQTHRKGRPVILSGYGVELALKKTDYIAMDDRDVSGEGDLKKGKDTQTPIKELDDQEIQDIKPLHPEDMSLLGMKAASFVMDSEDPLTTLLKLLQDFPKHASSVAAVGINPDVTDVLQGNWDSFLGPGQNALWINGVQLENSDTNAFALLEHLRRERRFVNSFKTLGVNSSEAIQLLSHQVLANSKRDEVPQRFDYRDNIEGGKAIVWLNDLEKDSRYREWSAAVNTLLRRVYPGQLHPLRRNVHHLVVPVNLASKDDLALVTEQLRLFVDRKIALRFGVVPLAGTPEAVAQAKVFYYLNEAYGLPVALGYLELALGSGQSLKPDAKVLEQAIKEAELIEGRTALPLEEVLSSEAIGEHIKASKSWAGRMGANSLIPPVFINGLSLAKDEQWMQIMSARLQADVQFTQRAVYEEIANDETDFVALLLGNAATHRNAYIFPEGEESVKTINVGRLLQEYAGVFEKLPTIFSDKPDKLVESTIWVIGDFDEKDGYELLQGASELQKLAPGVNLVFINNPQLVSEKPALSTLLHQLHQVGFFKGPEQLQQLLEEVSPFKEHVDIPKVETLLQMQIPDVKPASWQFPNHIESGNFWKESQKMLKAAGFKPGQRGVIINGRVVGPVPVDEEFGAEDFRQLLEYEHSRRILPALEAANEIGVLEKLKGPQSSACLTNLIALSSIPEVPTSMFQGPSLARTDAFDKLWKQEHVAIESGDKDKATFQVVASIDPASELAQKWVPILKVLSEMRGVYIKIYLNPQKMIAELPVKRFYRHVLNSAPVFDENGNLIDPQARFENIPELPLLSLSMDVPPSWLVTPKESPYDLDNLKIQSLKDRLKGGDIEALYELRSILIEGHSTDIINGGPPKGVQLVLGTEKEPHFADTIVMANLGYFQFKANPGHYRMELKEGRSKEIFHIDSTGTKGIQRGNHEAAGEDSEIALLSFQGATLFPRLSRNPGMEVEDVLEQSTSVPKNVGDFATRLLRKVEDVLVNVGFLAPAADLKPQAEINIFSVASGHLYERFLNIMMLSVMKHTDKSVKFWFIENFLSPSFKDFIPTMAEEYGFEYELVTYKWPHWLRGQKEKQREIWGYKILFLDVLFPLDLDKVIFVDADQIVRTDMKELVDLDLQGAPYGFTPMCDSREEIEGFRFWKQGYWKNFLRGLPYHISALYVVDLKRFRQIAAGDRLRQQYHQLSADPNSLSNLDQDLPNHMQSMLPIHSLPQEWLWCETWCSDESLKTAKTIDLCNNPMTKEPKLDRARRQVPEWTAYDEEIAALARRNLKKEGEESETTKQLEKGETVEALKESEEPTIKQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHN7</accession>
    <name>A0A2T6ZHN7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1091380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000257">
        <property type="protein sequence ID" value="PUU74992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHN7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHN7"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="252"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="57196" checksum="BDA399795895ED2B" modified="2018-07-18" version="1">MAPSAVSTIDNTSTSGTKNTNAAKPTTPIPSLEVGLLEKLEAPLADVPSIARAFEVIYHNLALTASDQFLPTPIRALPTGEEKGRFLALDLGGTNLRVAVVWLYGGDGLKVCTQGSWNIPEHLKSGAAEVLFRWVADRIGDVVGEYLGDVGSEEKERILSEGMELGVTFSFPMEQTTHDSALLMPMGKGFTFTTTNDLSSLLKAAYDDLLSTTTPTYPLPRLDIVAITNDSISALLSAAYLHHSTEDVRAVAGIIAGTGTNATCLCPVSKLPASKQPTSGSSTGAILLNTEWSIRGTAPPLKPYTTTWDVQLDLENEKPGFQPFEEMVGGRYLGELVRLVCLDLFSSNVPKSQLPEKMKLRYGLDTKLCSDVEASVNDDEALSLLQDYFDPDTSSSTTSSAATTTSSEEPEEWKWDLLSAASFRRISTAVSTRAAALVAAATIGVLGVNDELKHHAEKQVLVCYTGTVLEKYPTFRERCEGFMMEVVERWVAESRIPPAPSGKRRAVRLVEAKDGGIVGAAVLAGMVKEGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHT4</accession>
    <name>A0A2T6ZHT4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_374231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000254">
        <property type="protein sequence ID" value="PUU75043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHT4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHT4"/>
    <dbReference type="OrthoDB" id="4776947at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015457382" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="15766" checksum="CA795CBC6636BD23" modified="2018-07-18" version="1">MFYKPTVLTTLVLLFGLLIRSSTAATPPACVLACLNEQGTLSDIEKLCGSDKIGACLSSKCGDSLKQAQDHFTNTCKANGYTASLGSSSSSTASSSSATVTSSSGSHATGTTGGSPTGGSGSGRNGTAPTPTTTPTGNSASSLNVMGGALALVALTAGFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHU2</accession>
    <name>A0A2T6ZHU2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1131957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHU2"/>
    <dbReference type="OrthoDB" id="5454865at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015636708" evidence="1">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="13264" checksum="EBE9CCD43C94AA32" modified="2018-07-18" version="1">MQFTTLISAFVFAVIALAAPAPAAPTPAVDSSMETKTGATAWEFHPFLDASCQTPTGDTLGGSQAPGSQCINVTERYGDKVYSAASTQGCKVYVFLNGNTDCSGTPEPATSNTCSPYPTPISSIRVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI16</accession>
    <name>A0A2T6ZI16_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI16"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="140" mass="15453" checksum="AA4AF26CC535AD6D" modified="2018-07-18" version="1">MHKFPEPKKPNFGYPAIQPSSPSSLSEILSKMYFRIGTFLSIPALSPTEQSSVMRGSRTKPSTGYFHARLFSPFWGCRRVYVAYAGMGHWCILLVTLASVGTDGTALVASPFLGVFEYGKEGEEGGLRKWPLVEDRAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI31</accession>
    <name>A0A2T6ZI31_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_372997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000252">
        <property type="protein sequence ID" value="PUU75074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI31"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI31"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="286" mass="30535" checksum="EEDBF18108A8CE02" modified="2018-07-18" version="1">MPHSTFHTSFPSEIGSAPEGITVGSSASSNLVPSSSSSSQSQTQVQEVATVAAAAGTGISHQHPHLHQNIHTSKQVKKRLHMRSKSTTTLSSPHSSFSSPFHHHHSHSPTSATPRIFAPPLLRSSSLPLVPGTLSSPSPTTPRTLWMRAYPPPSPIRTSTPSPPPSLVNEPFISSSSSSITSSAPSTPTSLRSRSPSISSLETIPDSPDAEEEEEKAVEALKEEWDSRRRNTPSRSAGTDKRKRWSVCGAEKRGDLELETIWEEAGFGVEIVGRGPGDGMGEGEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIJ5</accession>
    <name>A0A2T6ZIJ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1090643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000238">
        <property type="protein sequence ID" value="PUU75302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIJ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIJ5"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="571"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="105"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU75302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="604" mass="63678" checksum="7309DB758A11A860" modified="2018-07-18" version="1">MGRSVSTSLSPPQPALKESHSTATMATTTDSSTLAPSVNNDMGTGEKGFLDNSRPVSPNLDSEKRPVTPTTDGGRAMNPDAGSEGGSEGSEDEIQYPGPVALTLITIALSLAVFLVALDQTIIATAIPKITDQFGALNDVGWYGSAYMLTVCSFQLVYGKIYTFFSLKWVFLAAIGIFELGSLVCGVAPTSKALIVGRAIAGLGCAGIFSGALIILAHSVPLRKRPMYTGFIGAMYGIASVAGPLMGGAFTDHATWRWCFYINLPIGAFTVAIIVLYFTPPKRAKADKLTLTQKLGQIDLVGTGVLLPGVVSLLLALQWGGTTYKWGSARIIGLLVTAFVLIVAFIVTQFWRQEKATIPPRILRQRSIAFSSILAFSIGSAFMLLIFYIPIWLQAIKSVSATKSGIMNLPLILGVVVLSILAGILITICGYYTPFMIVGAAICAIGAGLLTTFEVDTGHAKWIGYQFICGAGIGLCMQQPMIAAQTVLKLEDVPTGTAVIVFFQTLGGALFISVGQNVFTNKLVEGIAKNLPNLDPASVLNAGATSLKSSFPPDMHPAIIKAYNHALVECFYPSVAMAVIGVIASLGVEWASVKGKKVEAVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIN6</accession>
    <name>A0A2T6ZIN6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_922250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIN6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIN6"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="157" mass="17124" checksum="8799EE30D12BAF29" modified="2018-07-18" version="1" fragment="single">ISSLAAPDTASVALRSILINLVRNRDVYNAVMAELTSLKLSNPATWKELEGAPLLHAIVKETLRLHPPAGFNLPRAVPAGGRTVCGHYLPEGTTVGMSAWCVHANEDFWGKDTLEFKPQRWLDPESAFKLDRYGLSFGQGARACLGKNIAMVQLVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIX0</accession>
    <name>A0A2T6ZIX0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1090426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000232">
        <property type="protein sequence ID" value="PUU75445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIX0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIX0"/>
    <dbReference type="OrthoDB" id="5420391at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="442" mass="47594" checksum="49FD86536A664BCF" modified="2018-07-18" version="1">MSQDLLDDFFSAPPPPPPAAAGGFGQGHHRSNTNTTTFDDLLGLFDGQTATTQKPKPAQVLRLAHPGRPVSFHGNTTTNRADPFATFGNITGRPITPSPRPASIATFDDFFATVPAPQRNGGGIGTTLVQQREEEEDDDDFGDFTSAPTGGGSVLSPPLTTGTTFSSPPPSRGSNSSPPPSPTPPKPKYIRSRKVSDADPFGDFFASPSTTSPPRLSFGSPPRVPSIPLKSFASIPAPSPYRRPAKPIDIPPVAVLLRAFPPLFLLPQEQLLDKMKDLSFPLRQRVLSHHKTKEFLEAICEIGRVAGRIVAGRKRRTKSALPGKVGGGMKLAGGAGATWQQRKEDREVKEICRLWKEGSGRLKAAMGTSIPEFEDEPLKGPGRRECKLCRLGKDELLPGLKEKTERLGWWDGEWGGHAGCKGFWEKHGKGLVSTGEDFMGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIX9</accession>
    <name>A0A2T6ZIX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1030955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000231">
        <property type="protein sequence ID" value="PUU75447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZIX9"/>
    <dbReference type="OrthoDB" id="4066896at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021895">
        <property type="entry name" value="Bud3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF21">
        <property type="entry name" value="GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12015">
        <property type="entry name" value="Bud3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25351">
        <property type="entry name" value="PH_BUD3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="228"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU75447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1410" mass="156431" checksum="63ED6EFD7A1A0E7C" modified="2018-07-18" version="1">MASLSSPPPHLAHCTPYCTSDPVLGHVLVFFNPHSSSSSTSVSRIEAHILTCAGLQSYPKLTLSPSSPLYAAVNHLPSPKQNHEVYRGLAIAVLKYFSELPKTVKETILQSKKNNVLPNGEAQAVAFDEMHAGDLAARLKELELESLLGDLNSALAERFLTWLDIDLVLRSPADVEPDAVPEEAEKLLALFGEPTHLPFTKLKRTQSRPASSRPRPPKDSTEGIGRELEQLRITESSYVGKLQDLLDNLVKPLRGRASQRKGDGGFPNGRDLEALFPPSLDRILELNTAFLQEIETGSLPEVADCCLRRFPDFKESYEEYIQASSEFPQLLAKFAKDRHSSFSKRVQQAGEQKLRSMIIEPVQRLPRYTLLIDSIINLLAFDDPSLPKLIDAREIITEICSLQSSDKDERSKTTKRLQSIVVSWPPSLRLPGRLITAFDFLDVLPPFNDRTSEAIPSTILLFPDRLLILRRPKHTSMQARAIMAEVDKPGGGGISNYGSGTKREGLGCDLQFAGWMDLADVKFAESDGGDVIWMTLARDLRDSWDVRAGGMGIRRLRLLNAYEGRATKLTEDIVKARLEGRILNGIKGLIGLRETKVEGLGLWACVWGSEDRYTTEGKKGSVLVYIDDGGGGLGSPGKTGRELAADVGKGGVDIAVNVEAIMGNKLRVEFRSWNEYSSTDTVSREEFLAVFTKRLSSIVRLHSLPQHPPLTAPLMSANRKLLRSLGVPFDGESRFSRLRPPSPVKLLSSVFGSSNSNAPGTPGSPSKSRQLMDRTQSQMLPPKMLDRSSAMLQKRSTVLGIMGDWNGEPDEGDLEISSQSITMPSESPLKRLEETLGGFVKVLKKLSSAEHSDLMPLRNMQGVDDAAVEGFLGMMLTDPKTARNEKGMGIDIVFDAFKRFLRREWKDGMGSVIDGKGLVELRSKSDTLYPGDFEDFFKIFVLDWAPQNKRAFKTLVLLLKNMQNKVENPDDKGLLTKAFTELLVEDEDPLEFMPLVDRLVEEADNLFSEPLVINNGEFSLPNGNAVLRRNKSIHSGSNYSTASLRKRFGLTHTSSARDPIRGEHHGDSPKGASVWRTLSKNSRREELQKGHISRSKSTDYDARTYHLPKRPTSQDRPTAFSTFTPLPPSPSSPMRPLSATSGPTHLAGGKPLPPGPPVRKKRRSSLSDLTTHRDYEQILPARVSPDLEKMTTPTKSGISGLKDVENYRTESPSPSQLPKPIGAGTPSRKMSKNRIEIPVRKKSLGMSGSTGPQKLKMQSTQKLRERLQNEKQAITMVDQSLQHEIDKIGEELSLATRVSSRGVKELTGRLEQVEARLPQINELNAKYEALKKSSDVALAKKDRELEVMDKDFNDCLNENDVMFEKFNEELVKISSGVKAGRDVELLKILQEVRAEQAKLKRDNMAAEERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJG7</accession>
    <name>A0A2T6ZJG7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1130944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000220">
        <property type="protein sequence ID" value="PUU75638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJG7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJG7"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="234"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="35953" checksum="0C2544B58799B6FF" modified="2018-07-18" version="1">MKTNIPDSSDLPRPELKKLEYRKITPFQVSEAAWLTPVGRTGPQRLNNPPNSSGSNVDSAMIAIGYQETSRFERPPTLVRDLPDTLIDHQLQSIEVVGKVGYDMDDQNNKCVTTDKSHGRMREKEWVTLERSIPKTVAKPDGSSYGTRRRSSGNDDEEDGGEDSKSFTCDDGECENSNAIVFCDWCYLAVHQECYGVPHIPEGQRLCRKCLAMPNKTAHAPNPLRLKSTNHKNYRTSYSTPDTDGAFKQATNTKWAHFLCVIWISEVILGNTSYMEPVDGMNSEPKSRWKLVKLVVIIRVSWKIPNIQHQFSLAEQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJL3</accession>
    <name>A0A2T6ZJL3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_993582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000219">
        <property type="protein sequence ID" value="PUU75675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJL3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJL3"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22679">
        <property type="entry name" value="FHA_SLMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF46">
        <property type="entry name" value="TO VACUOLE TARGETING VPS64, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="172"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="305"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="750" mass="82007" checksum="9594A9FC470119B0" modified="2018-07-18" version="1">MTAVAQPPNFHSVPRSWNGSGQNNLNSMTHDDVARIFKSQRSSSVTSVSSSTSGTSNGSEASNGSWGNSVNGKKKGVSRAATRGTNTAWATKSDIMRVPGGSNQTPGGSLTGSNSSINGSHQAMPILPSQHLMSGQTQQNGGPLPPSYLMLLPLNGTFDRKFIPLPYWPDTLRIGRQTNTKTIPTQNNGYFDSKVLSRQHAEIWAEKLSGRVWIRDIKSSNGTFVNGQRLSQENRDSEPHELRAEDVLELGIDIVGEDNKTIIHHKVAARVEHAGLQTPNVGNLDLNFADIDPMNSVSIMNSQNNSVPLQNTSIRGRSGSQGSRSSVMSGGPVSHRQPQMMIAPVTMEMVVKKLNYELQAAKQQTQDLQRTSEVFDSLLSSRPITALGHIAPSANPAPTEPLPAPPIPVHTGLAQNQVSASSPIPLSAHIQEHLRNQQAPDSSRNTPKLRSENTERPEPPQQLHGLADALEEARKELQAKTFRVKELEETLKRERSAREVAEVRAAQLENASRAVRETSRERGFKEFDAEKIRADEAIGLSDEFHELRNEKLLDGQPEALDEEDRDIYDDDTTGVKVDPSAQAAAEAAERLQRRVEQMMAELQSAKEEIERYKRQAEVAEHEGAKSKRTLSEMVEKIRKDERARKLLHEKEAASQTDSVAVKNTSIQVSSEDIEEAGDGFHLNGTIKPTGGKVAALNGSRSSGQVISKRSKESNLAISKRDAAPYATMIGVMLIGVGLMTALNRWHKAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJV5</accession>
    <name>A0A2T6ZJV5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_993179</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJV5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJV5"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015630003" evidence="13">
        <location>
            <begin position="19"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="86"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU75779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="396" mass="43205" checksum="0F272980BD59E3A8" modified="2018-07-18" version="1">MKSSILFAAGSLLGSAMAGVHRAPLKKVPLTEQLSHHDINTQMKALGQKYMGIRPEKIGEEMFKTQEIKNDDGHPVPVSNFLNAQYFSEITIGTPPQSFKVVLDTGSSNLWVPSSQCGSIACYLHSKYDSGSSSTYKANGTSFEIRYGSGSLSGFVSQDNMEIGDLKIKHQTFAEATSEPGLAFAFGRFDGILGLGYDSISVNHIVPPFYQMINQGLLDKPVFAFYLGGTDDQSEAIFGGIDEDHYEGKLIKLPVRRKAYWEVEFEAMTFGKATAQFDNTGAVIDTGTSLIALPSTLAELLNKEIGAKKGFNGQYTVECEKRDSLPDLTFTLTGHDFTITAYDYILEVQGSCISAFMGMDFPEPVGPLAILGDAFLRKYYSVYDLGDHTVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL28</accession>
    <name>A0A2T6ZL28_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NUC071 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1130274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZL28"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="2122"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU76124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="2359" mass="273492" checksum="E7512F613A1C0350" modified="2018-07-18" version="1">MASLPPPPPPGWQGVSGSGAPLQPPPPGYRPPADPQQAKFDQKKKEWLRIQKNRFGEKRKNGFVDTHKADMPPEHLRKIVRDIGDVSQKKFSADKRAYLGALKFMPHAVLKLLENMPMPWESAREVKVLYHVNGCLTLVNEIPRVIEPVFHAQWATMWVCMRREKSDRRHFKRMRFPPFDDEEPPLSWSENIEDVEPQEPIQMELDEHEDAAVIEWFYDHRPLLDTPHVNGPGYKRWNLDLSQMATLYRLSQQLLSDLVDKNYFYMFDRKSFFTAKALNVAIPGGPRFEPLYKDIDPNDEDFGEFNAIDRIIFRSPIRTEYRVAFPFLYNSLPRSVHLSWYHYPQITYVRAEDPELPAFYFDPVINPISSRSVAPTNLTVSHEDEVFGYGNDEDDFQLPDEVEPFMAEEALYTENTTSAIALWWAPYPFDRRSGKTVRAEDVPLVKQWYLEHCPQGQPVKVRVSYQKLLKTYVLNALHTRPPKAQNKQDLFRTLKGTKFFQTTTIDWVEAGLQVCRQGFNMLNLLIHRKNLTYLHLDYNFNLKPVKTLTTKERKKSRFGNAFHLMREILRLTKLIVDAQVQYRLGNIDAFQLADGILYAFNHVGQLTGMYRYKYKLMHQIRACKDLKHLIYYRFNSGPVGKGPGCGFWAPAWRVWLFFMRGILPLLERWLGNLLARQFEGRHSKGVAKTVTKQRVESHFDLELRAAVIHDITDMMPAGMKSNKVNTVLQHLSEAWRCWKSNIPWKVPGLPAPIENVILRYVKSKADWWVSVAHYNRERIRRGATVDKTVAKKNLGRLTRLWLKAEQERQHNYMKDGPYVSSEEAVAIYTAAVHWLEARKFSPIPFPSVSYKHDTKILILALERLREAYSVKGRLNQSQREELALIEQAYDSPGTTLTRIKTALLTRRAFKEVGIDMNDNYSTINPVYDVEPIEKITDAYLDAYLWYQADQRHLFPAWIKPSDSEVPPLLVYKWAQGINNLHGVWETADGECNVLLETQLSKVYEKIDITFLNRLLRLIMDHNLADYITAKNNVVLNYKDMNHTNMYGLIRGLQFSAFVFQYYGLILDLLILGLERASEIAGPPQRPNEFLQFQDLETETKHPIRLYTRYVDRIWVFFRFSADDARDLIQRFLTEQPDPNFENVIGYRNKKCWPRDSRMRLMRHDVNLGRAVFWDLKNRLPRSVTTIEWEDTFASVYSRDNPNLLFSMSGFEVRILPKTRNQNEEFPVKDSVWSLVDNNSKERTAHAFLRVTEDDIAKFNNRIRQILMSSGSTTFTKIANKWNSALIALFTYYREAAISTEALLDTIVKCETKIQTRVKIGLNSKMPSRFPPAVFYTPKELGGLGMISGSHILIPTSDRRWSKQTDAGITHFRSGMTHDDDVLIPNIFRYIQPWEAEFIDSARVWSEYAQKRAEANQQNRRLTLEDLEDSWDRGIPRINTLFQKDRSTLAFDKGWRVRTEFKIYSMMRSNPFWWTSQRHDGKLWNLNAYRTDVIQALGGVETILEHTLFKATAFPSWEGLFWEKASGFEESMKFKKLTNAQRSGLNQIPNRRFTLWWSPTINRANVYIGFQVQLDLTGIFLHGKIPTLKISLIQIFRAHLWQKIHESVTMDLCQVFDQELEALGIETVQKETIHPRKSYKMNSSCADILLFAAYKWNVTRPSLLHDQKDVIEQNATNKFWIDVQLRYGDYDSHDVSRYVRAKFLDYTTDSLSIYPSPTGVMIAIDLAYNLYDAYGQWFPGLKQLVQQAMAKIMKANPALYVLRERIRKGLQLYASESNQEFLNSQNYSELFSNQIQLFIDDTNTYRVTVHKTFEGNLTTKPINGAIFILNPRSGQLFLKIIHTSVWAGQKRLGQLAKWKTAEEVAALIRSLPVEEQPKQLIVTRKGLLDPLEVHLLDFPNISIRASELQLPFQAAMKIEKLGDMILRATEPQMVLFNLYDDWTKTISSYTAFSRLILILRAMHVNPDKTKLLLRPDKTVITQEHHIWPTLSDDDWIKVETQLRDLILNDYGKKNNVNVSSLTSSEVRDIILGMEISAPSMQRQQAAEIEKQQQEQGQLTAVTTRTQNVHGDEMIVTTTSNYEQQAFASKTEWRSRAIAASNLRTRSNQIFISSDDISDNGQYTYIMPKNILKRFIMIADLRMQVAGYVYGSSPPDNDQIKEIRCIAMIPQIGSLNTVQLPHQLPQHDYLTKENGLEPLGWIHTWAQPNETPYLNAFDTTQHARLMSAHKEWDKKTITMTVAFKAGSVSLAAYGLTPAGYEWGAQNKDLGNDMPPGFQSNMGEKCQLLLSDKIMGFFLVPESGVWNYSFLGANFSTEAEKKAYHVKIDTPVGYYADIHRPLHFQNFAELEDIWVDRSDNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL45</accession>
    <name>A0A2T6ZL45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1088812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000197">
        <property type="protein sequence ID" value="PUU76208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL45"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL45"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000266">
        <property type="entry name" value="mRNA transport regulator MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057941">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058537">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF53">
        <property type="entry name" value="MRNA TRANSPORT REGULATOR MTR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24138">
        <property type="entry name" value="TPR_TNPO3_IPO13_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24139">
        <property type="entry name" value="TPR_TNPO3_IPO13_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="968" mass="108719" checksum="7FA14D1A2AA4B2C4" modified="2018-07-18" version="1">MASPNGPSDQFAPVLAALATMQGNVDREQKYQATQFLEHFQKSPEAWTVVHAILQSENAGVEAQLFAATTLKGKITYDIHQLPRDALVDLRNSLLSLLVSYRSGSRPIRTQLCVCLASLALQLLEWKDVISLVVSTLGNDVESSVCLLEFLKILPEEVTEGRKVSLTEEELETRSRELLTDNAAEVLRLLVQYAQSTAGSPPNPALISCVNSWLREIPVLDIIGTQLIDVIISALSSDAALDPAVECLCNIFRETREVDASQESIQILYPRVMNLRPNIRKAVEADDLETFRGYTRIFAEAGEAWVVLIARMPADFRELVSAIAECAALDAERDVISLTFNFWYELKNYLVLEKYIEARVKIADIYSQLVDIMIRHLHYPKGSEADPFDGDREAEEKFREFRHSMGDVLKDCCEVIGSAACLGKAYAEIQTWMQRYATGPQKPVSGQVENWQSLEAPLFSLRAMGRMIPADEEQVLPQIMTSLVQLPEHDKVRFAATLVLGRYTEWTSKHPTYLEPQLNYITRGFEHNSKDVARAAAMALKFFCQDCGKLLVDHVGQLHSFYEQVAGDLPIASLYEVTDGVAHVVAAQPLDKIYDALRLFCEPIAKRLMEKANSANDDKAKCELADYIQLLTIFVQVVHPHVPPGTLNPMIRFWSGLVPVLGTILDNFVDFSPVCERVSRCYRTMLVSYRTDMLPLLPQLAEKLVTCFQKSHQGCFLWVTGAVIREFADEELVDEATRASVYQFLEQQCLNMFRLLNTKAATEIPDVIEDFFRLLVDGVMFHPYKLILSNLLQPIFEASLHSLSLEQVDPLVAVLQFLRDVLAYGRSSPPTSAYPDNPKEVQEAVKAMALSKGELITQKILSGLMYSFPRDCVPDSSGVLLALVELCPEPWLQWMKQTLELLPAGSISPAEAQKFLTTLEGAVSTRDFKKIRYSLQDFTNWYRRKNVTPRTAVTGIEGIEGSRFSFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLD8</accession>
    <name>A0A2T6ZLD8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000192">
        <property type="protein sequence ID" value="PUU76307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLD8"/>
    <dbReference type="OrthoDB" id="10543135at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="297" mass="33085" checksum="E323499F8AB1C6C4" modified="2018-07-18" version="1">MNTNMFDELKDTTIIDGLKFFVTNRVRPPAQRLYRCLTFSNKSERSHKGYSQNFNFTYVPAYHNHVSPSNSPPEQDETASATADQMRMQEQQTLEARVYAWMEGIPPEDELMDPNSNEADGASDSEREWVRAVSPSSIGSSVGRRRSSTSIIVGGEAADCFYHRDRRDAVMKGKAIEDEYARIVEALAPQMRSISQLSGTVSPKRVASKGDKKQNLAAGPSTTKPTQNTPPPAKFVHAALDIPETESLERLIQESIASGVAVQTPPPDLPQSSSQPYPFLKKSKSKRLSLWKRLTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLF5</accession>
    <name>A0A2T6ZLF5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_985329</name>
        <name evidence="1" type="ORF">B9Z19DRAFT_990930</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000192">
        <property type="protein sequence ID" value="PUU76322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000137">
        <property type="protein sequence ID" value="PUU77863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLF5"/>
    <dbReference type="OrthoDB" id="5402048at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29958" checksum="BEF31694A86A129D" modified="2018-07-18" version="1" fragment="single">SALRKTVVEIQAADLGKVYVHRALLNREVTAFEECGWSYFPSSMVVSFVEYLYQGDYTSPPVELLPYYSGSDKTNALAGQARSSNSVTPPPVGPLSYEKAFLTHAGLFILARHGKVLPLASMCLTRLKEVMREARDTAKESMFVENMRTLIRFLYDPCCNGSDGVWEELQKAVCGFLVSQRGWLLEAPGSDLICEEEQFAKDLLAEAINLLIDTDKLRVAAENSSEAMRLATAIPGNRSGRKKKRQALIISILVKSMKSSTLIVWCFSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLG3</accession>
    <name>A0A2T6ZLG3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NUC173 domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_991078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLG3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLG3"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="13"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="337"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1042"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1157"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1248" mass="138013" checksum="E7E40D5CD09A6D1F" modified="2018-07-18" version="1">MSLEAKLEKIRSPNLQNQRQVAVVLSAVEDILREQKTEFTPAAYFAALLSLLQQATSTSVVLNKDLAASTVYLLDLVTPFAPPPLLRSKFPQILSHLVPALIANDADAPLLRSSIGCLESLLVAQDGPAWAIPQRDIGPRRALAGLLNLGLENRPKVRKRAHEAITKVLKCSPPSPSLDHPAAEMCATITLQSVADLAIASEEQRKKSGEHDPRVIHSLQLIKAVAGAGGWPSKKVEGLCEVLLSVSKSTNEYMMMAAFGVFEEMFAGLVNGVASAKLPRVIEVISELRPSQNDSQLLPSWLVVIARGYEVYAQVSEDEAFVKLPSLFETIAPFLDSQAYTIRTSSAQCLISLATNCIPDSFLFDITRFTENIFKRITAITTDLLSVRFQGAWNQVFNILSALFDKLRWRSIPLLDEAIKIIGGLRSNEGFQGKKEADEVLGRAVRAVGPDSILSILSLNLIKPASGAPGRAWMLPILRDWVENTKLQHFRKEFVPLSEAFFQKVVDFGEGKEKTVEIKIFETLVGQIWALLPGYCDLPLDLTEAFDQSFAELVANVLYQKVDLRSDICRALQQLIDSNKLVLEVPLEDDEENLVIQRRVSKADARKNIKHLASFSGNMLAVLFNVYSTTLPQYRGFILKCLNSFLSITPDTELMATFQKVTSMLETTLAEPVKKKSEAEATGNTKMAPMAHTLMDLVITITPYLPSGSHQSLFTIFSVTVNKSEDPQLQKKAYKIIPRLAEAEYGKQALIEKSEDLQRFLIGAAEKVASPARRDRLIALSQLVEFLPTTDLHFIPSILSEVIISAKEVNEKARTAAFDLLVLMGEKMKSGGTVINSKVAHMPPDAPNVTATLDEYITMVSAGLAGSTPHMISASITALTRILYQFKDDINKPLISEMITTLDLFLTSKNREIVRSVLGFIKVCIISLPKETMLPRFSTLVPNLMIWSHEHKAHFKAKVKHIIERMIRRFGYGAVEKHVPEEDKKLVINIRKTRERRKRRKDAIAANGDGDGDEEDADTAPRTRRQSKFASEFEAAIYDSDSDLSCDSAPEADFAPRRKNKRGDKSGEAYIHEEVDEPLDLLDRKSIGNISSTRPQRTRIGDMRKSATTKAKTNRDGKLIFGGEDNNDAERDGEDVGMGAELTPADGVNAYVQAITGKDAFVRGQRGRVKYSNKRGRHDDDDDGDGDNGDEEMEVDTEDRRGKGVYPLGGGGGGKKKAGKEMSGRKGLGVKRVREGRVGKSPKRKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLH1</accession>
    <name>A0A2T6ZLH1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_256952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLH1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="193" mass="21197" checksum="ABDFACD35EF5CA48" modified="2018-07-18" version="1">MCCGFSGQSGHGTPCRKPQNTMLVVQGLSESQLKSWQSLLCDLLQRLGQTFRQPPVLYSYSILIGRDKLLSLNYPTPLFTFPFRKVNVGQNTTTTLTISPLPNFWGFIGLGFYHLGITHHATLTLRACLYCELWFTTPSPSLVGISPMGLGDTSPLPPPFRGGCTLSKTPTSNYAVGWISTLGVRLARASFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM99</accession>
    <name>A0A2T6ZM99_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1129455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000181">
        <property type="protein sequence ID" value="PUU76620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM99"/>
    <dbReference type="OrthoDB" id="5424391at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="387" mass="43395" checksum="543F8F268608B2C3" modified="2018-07-18" version="1">MQPSALTRLRLTLAFFKLHNVLHPQLPLTPLERNRLLGLVKDSFRQQLNSVPTPPTDSHVGNLLVTLPFSTSLDGRKGLEKINEDPIGVFEQQVLTGRATLGLAGLCLNKYVEGIKAKRWRVGEESALGRVLEGLQKSGLVTKINAITNSPITQPIVGTLVAEGRETKIIDLLSTASISDREKLRILQFAIVAMESKDGIGKAVEMFEKSLRTFGNKKYQYGEFQPVGLQLCRKVKDGESNKQLLEKLVSSAELWAKSPFMEAAIHLRFGRRTDTAINYFLSLDKDGNEFWGSKNKNWYHRSAKMGLELGMVCIERENWEDAATITDIIRRRFCGRVAGLFAHELGVRDHGTARDVLQKALEKVRMRGELLSKERSVGDMLNRWATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMG8</accession>
    <name>A0A2T6ZMG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_231012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMG8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015432565" evidence="3">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="162" mass="17556" checksum="3BDA07F3AE1D7DE3" modified="2018-07-18" version="1">MVFSASISGVLIALLIIMQTLTAVLALPTATTTTSTITTTTTTTTSASPQLEARQTLDSNQDNNNNDHSNDTEIVPPNNATTSKREFAIRAMLPQFNKRDNSENQEHGSNGMSPGEVLAIVIAALTLLVSMIPLFRCPRLQCWISSTISPFVQSKWHHGGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNS6</accession>
    <name>A0A2T6ZNS6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1128714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000162">
        <property type="protein sequence ID" value="PUU77140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNS6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNS6"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="148" mass="15798" checksum="7E09F36C9E10BEDE" modified="2018-07-18" version="1">MLGTTLGLALGAKRSALIFRAENAHRIPQTTRGWYFYHKSKNYYTMLGAAREGVRSGARVAGWVGGFVLAGGVVGEVLGPLGGGVVAGLSVAGVFSWINRFSYGMAVTTAKRGLVFGLLFGAGEEAIGYIGRKKREIEEQKVLQETSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNT6</accession>
    <name>A0A2T6ZNT6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_987686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNT6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNT6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="117" mass="11003" checksum="8C73B32A03A41DDB" modified="2018-07-18" version="1" fragment="single">GVGPAGPSELPAGPSELPADPSELPAGPSELPADPSEPPAGPSELPADPSEPPAGPSELPADPSEPPAGPSEPPADPSEPPADPSEPPADPSEPPADPSSSSSSPPSSAASSSTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNW8</accession>
    <name>A0A2T6ZNW8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000160">
        <property type="protein sequence ID" value="PUU77180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNW8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="164" mass="18748" checksum="A8A2A8F56F06E6F9" modified="2018-07-18" version="1">MTDRIRGTQPYSLTANLHSNFRRRAADSERQPERSIAMPSENDTLPADLGRIQPALRQTSRDARLWGSSMIMCDRLSLLSFKLSFLEESHARTPATLIFLDIPSLKEESYSSAAKALATRYHLHTFNLGVHSQIVLRRVSTFLSQHKISLQDVSNHVYWDTQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNY5</accession>
    <name>A0A2T6ZNY5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 21">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 21">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B9Z19DRAFT_988026</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 21">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 21">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 20">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 21"/>
    <dbReference type="EMBL" id="NESQ01000162">
        <property type="protein sequence ID" value="PUU77134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNY5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNY5"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0129">CBS domain</keyword>
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    <keyword evidence="10 15 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 21" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="127"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="22">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
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        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15 16">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <begin position="334"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 18">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
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        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
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        </ligand>
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        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <location>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
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        <location>
            <begin position="374"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
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        <location>
            <begin position="397"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
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        <location>
            <begin position="422"/>
            <end position="426"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <location>
            <position position="456"/>
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        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022755"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PUU77134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="530" mass="56741" checksum="E346763F90C76025" modified="2018-07-18" version="1">MSSTAANIETLDCSTALSVLEKDYERDGLDVRSLLDTSKHGGLTYNDFLILPGYIGFPASDVTLDSKITKRISLKLPLVSSPMDTVTEEQMAIFMALLGGVGVIHHNCTAEDQAEMVRKVKKYENGFILDPVVMGPKNTVGDVREVKAKQGFAGIPITEDGHLHSKLIGIVTMRDIQFHKDNTTALSEVMTTELLTAPEGVSLPEANGILRSSKKGKLPIVDKAGNLTALLSRSDLMKNLHFPLASKRPYSKQLLCAAAIGTREDDKARLRKLAEAGLDIVILDSSQGNSIYQISMTKWIKKEFPNIDVIAGNVVTREQAANLIAAGADGLRIGMGSGSACITQEVMAVGRPQAAAVYNICEFASRFGVPCIADGGIQNVGHIVKGLALGASTVMMGGLLAGTTESPGKYFLSSEGKLVKAYRGMGSIDAMESMRTGNNAATGRYFSEGDKIRVAQGVSGSVLDRGSVTKFVPYLQAGLQHSFQDIGVQSVSELQQGVKDGIVRFEIRTVSAQAEGNVHGLHDFNKKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP83</accession>
    <name>A0A2T6ZP83_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N2227-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1101951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000156">
        <property type="protein sequence ID" value="PUU77300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP83"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP83"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="330" mass="37742" checksum="7C77152F59FE33BB" modified="2018-07-18" version="1">MPSGYLERLNETSNLIKKNNQIAQKILDHSLAFYKIPLPDLLHFQSAHKSDQRPIGDHTSVVQSLQHFVRDWSTDGAYERESTFVQILSTLSTIFPEADLRARQKILVPGAGLGRLAYEISALGFTTIANEYSFYMSMAHRWVLSLADHDKGGVQQHTYYPFLNWWSHQRESRNVLRGVTFPEVHPSSEALKRYTLLEGDFTKLFLDDRERGSYDAVVTLFSIDTARNIVEYLESIHAVLKIGGTWVNLGPLLYGTAPWVEPSLEEILQLTQRLGFELLPTDGHFGTDSFSDQVLEWRGKVRGCLAGYNWDKESLNRNAYEAQFWVARKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPG8</accession>
    <name>A0A2T6ZPG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1086505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPG8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPG8"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="505"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="646"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="699"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="861" mass="94056" checksum="E8CBB6E42FB665F0" modified="2018-07-18" version="1">MSLKTHFRPEKVIQPFYTGGKVALDQSGRILVTALDEDVLITNFQTGEELARLEGDTEPVTTLALTPGASHLIICSRSYSMRMYSLSPTYGENTASVKSTLLRSVKAHTAPVIVAETDPTGTLLATGGADGLVKVWDIKGGFVTHNLRGHGGVISAMKFYKPENVVRNERKSRKSSKATADSEVIGWRLATGADDAIVRIWDLETSKCIAALESHVSVVRGLDWSQDGRTLVSGSRDQVVCVWDAKSLKLKGTIPILEELEAVGILPTGTLSLEGVEGQVLYMGGRKNRVRLWDLSGGKEITQAEDGDEEVGNAEGIVDILYNPSLNSLISVHNDQTLLTHSLKLPTSTPANLPITRRISGHHDEIIDLQYLTPSSSLIALATNSEDVRVLSVNNSFSDAGVLRGHGDIVICLDRDWSGYWLATGGKDNEARLWHIDDKNNSFTCHSRYTGHAESIGAIALPRKAPPAESKASRKFPAPKFMVTGSQDRTIKMWRVGKSKATYTKKAHDKDINAIDISPDDSMFASASQDRTVKIWSLEEGEVTGILRGHRRGVWSVKFAPYSITAAVVGGVEGTKGGRMVVTGSGDRTVKLWSLTDYSCLKTLEGHTNSVLKTVWLTGGLQVASSGGDGLVKVWDVKSGECNTTLDNHEDKVWALTARPDEQVLVSGGGDSVVTFWTDVTIEIAETTAKEEEAQIEQEQALQNHIRNADYRAAITLALTLNHPGRLLNLFTAVVKTSPAEESSISGLLAVDEIIGSLSNEQLSVLMLRIRDWNTNAKTATVAQRIMHVVFRKYSVQRLLELKVDLAGWEAILSYTMRHYRKVEGLVDESYLVDYTLREMEEMMEEDADAMDGVETAAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPQ1</accession>
    <name>A0A2T6ZPQ1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_171876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="NESQ01000152">
        <property type="protein sequence ID" value="PUU77470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPQ1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPQ1"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025095184" description="Carbonic anhydrase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="10">
        <location>
            <begin position="45"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU77470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="299" mass="33509" checksum="5FAB1C9E8F93866E" modified="2018-07-18" version="1">MHSSPTAHLLLLFTSLLTITHALPNTQSPLLLQPETSPSNSLTTAPWGYHYHSGPLSWHRLSPSNTLCKTGLRQSPINIHKSLKRPTGLKLRRGDYREYGILSNEGQTVSIKPQEDDAKYGYQLFPGDPSSPPGSPGGPGIGGWALLETMHFHTPSEHHLDGEHFVGEIHAVFKATDGQTTILSTLLDIDTTSSNHLLTTLHPWLPFVATPLTATFVQFDPSPILDRFYRAYRRERVYTYRGSLTTPPCTEGVTWMVSQDPEKISVEHYRRLKAITKFNARYSQNHPGYMNLLELACEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQL4</accession>
    <name>A0A2T6ZQL4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1127815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000141">
        <property type="protein sequence ID" value="PUU77779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQL4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQL4"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17266" checksum="81D4193F1F3FB93C" modified="2018-07-18" version="1">MPGPSPSPLLTAATALCSTLSQSPPPPLPTILQHFTETATAYEHGLPQLAPFLGRELPIPDYFNILADNLSFRNMQFKEYIVDEENHKVFVRGTGRFIWTTTGDAWDECFVYLLDFVKGGGGDGWKVGRYQVWADSGAAYLARIGKLKKVQSGEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQQ4</accession>
    <name>A0A2T6ZQQ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_985551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000139">
        <property type="protein sequence ID" value="PUU77812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQQ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQQ4"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="124" mass="13719" checksum="0982CE273493C926" modified="2018-07-18" version="1" fragment="single">MGCDTTKLQHYCDRCQLPHTSTVLHWAAKGENAELVNFLLDRGENIDAVDNRNATPLHWVCSEGGTEVVKLLVSRGADLEIEDCDGDTALRWAAERSNAPVFKLLLDSGCSKKQLNLKSETVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRG9</accession>
    <name>A0A2T6ZRG9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_984235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRG9"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="348"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="626"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="671" mass="72574" checksum="89B412959E2EB0A3" modified="2018-07-18" version="1">MIEDDTAEDLGAKPLIPEVDLSNALRHLEILLSSQPSPTLPQRLIAPILLPLWALTNFAKSTRRSTWYERTLLLLKTYIKTSPDESVLQKIQGQILYSGGETWEFGPGSEGGIEIRSRIGGAAGFDVGETEARVQEFLGLLEDGGVSGAVLNDFFLGILRTWLGRRNSETEDPVKMFTALKILQEVLGRHEETLAKNPTQILQIVKGVLGEHVEYQESLKIPSEDISTPSLGGLGKIVSNSPSPAPKADGADELDEEDGRTQTLTMALSLLSVIISNPTTKLTPSDERLIQTLQPALTHITTSKFTNPDIKTLTLNITSLLTLHSSAPPPSSSSSTATLLTRQRETYTLALSYLQDPLIPVRAHGLHLLRELILSSSPVINIQSTLAQLINQLKDDDSFVYLNIVKCLSALTERHSGTVTRMLVEAYLDDDDNGKGGGEGGKEKLSLDERLRLGEALLATVQRLGGALAGETARIVGEGMIALVSRRRTRRQRPSDSSEEWDTNTQGDEEEDEALTSHATQILTSWPSTNETEDQRMRTSGLSILGAAIETNPTGLGQRIISDALDVCMSILTLETAVGAAILRRAAVVCVCGILKALVGLGGDGDGDGEVWREGVWEVVKGRIVEIRRVVGYLLVTDGDGLVREQARVVIENLDAVVGVWVGRGGASALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRU8</accession>
    <name>A0A2T6ZRU8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">6-O-methylguanine DNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_983983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000127">
        <property type="protein sequence ID" value="PUU78219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRU8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRU8"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="141" mass="15130" checksum="3335237C22DE695E" modified="2018-07-18" version="1">MPQSDEAAAFFEAVYMAVQEIPHGKVTSYGHIAHLIGKRKQVGQALKHLSTDPANTFHHGNVPWQRVIAAGGVIPRRDNSSGAARHAEVLRGEGVIVTTRGGGGGLHVDMSGEYGWFPNVLPSKDGGGDWVSEETMFPVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRW1</accession>
    <name>A0A2T6ZRW1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1127102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRW1"/>
    <dbReference type="OrthoDB" id="5365666at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="262" mass="29446" checksum="C8CCFEC5FA7C253D" modified="2018-07-18" version="1">MSMQQCRPVPGPSGPPNTLVRITNEETESEIASILTIAGSTMTKIRRKTYRWSQGSRNREHSLARANVYETQAFAQFDYIASCIQDYWSSHDDIGAREFIRDISEAKDNLLTIFGDLVFEIGNTGWTKLESIEEVEEEEEEEEGCEVGSPRAYHIGVRRGEEDDGSKTVMTDVEESTARLVYAIRFPEDPITSASTGKTLRERISLTRLGFRPSSRNGVPRGTAPAVENRAERKRDKVKRVLRRLSFRGKGSAMSFPPPALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRX1</accession>
    <name>A0A2T6ZRX1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1084463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRX1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRX1"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="247"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="427" mass="46750" checksum="98C9E34A1575326C" modified="2018-07-18" version="1">MLPVKKKLRKSLDSSFFEPKLQRDRRGSSADPGTTKGDAEGSTAEYVSEEGDERLDTDTKIALLASLHPSVSTAALMDILLSADGSIKATSQLLATGQTTLQARKPPSSTNQSSLESFISTQSTSTTAAAPKPPPKGQTMHLYTPALIALHTPCILHPTFLLPHLATALLQELLQESTTFPPPGKFNLFSRTVQSPHRSVMYTTTPATTPYYYQGITLPPPRAFTPSMSTAAGLVEKYFHTLEPRGRITAALVNCYSGPQQGVGFHTDALTYIGPRAIICTLSLGVTREFRIQKQPPTSHSSGTYAIHLPHNSLLVMTAGMQENWKHSIPLVQRVDRHEVSGDVRIAITFRWYRDDYGPEVTPACGCGGRMVLRPVWGGEKYFWSCDGEYRGVGQGCGYFKWAVFGEGGRPVFDEEKGKTVVRDDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS00</accession>
    <name>A0A2T6ZS00_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1084380</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS00"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS00"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071554">
        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="15">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="16">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU78269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="364" mass="39870" checksum="C72D996106BB2C3C" modified="2018-07-18" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFGNKPMILHQVESLAAAGVTDIVLAVNYRPDVMISVLKKYEEQYGVTITFSIETEPLGTAGPLKLAEKILGKDQEPFFVLNSDVICDYPFKDLAAFHKSHGQEGTIVVTKVEEPSKYGVVVHKPGHDSRIDRFVEKPVEFVGNRINAGIYILNPSVLNRIELRPTSIEQETFPAIVKDGELHSFDLEGFWMDVGQPKDFLTGTCLYLSSLAKKNSKLLTPSSEPFVYGGNVLVDPTATIGKNCRIGPNVTIGPNVVIGDGVRVQRSVLLQGSRIKDHAWVKSTIVGWNSTVGKWARLENVTVLGDDVTISDEVYVNGGCVLPHKTIKVNIDVPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS61</accession>
    <name>A0A2T6ZS61_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_86884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000122">
        <property type="protein sequence ID" value="PUU78332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS61"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="16452" checksum="15586B049C4C1D12" modified="2018-07-18" version="1">MLPNFTVSEIAVPHCLLGPKMSVIGCRATKRSALFLKRSTSKVSRRSYRRSGYCDWLKWVLASKLESLQGELLFPSRLLTPISPAAFGCPFGITSAFAQVRADSGHARAQPVGYLHLARLTTDSKHDMLSKVCNAPPSAHRGRKCLEPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZST2</accession>
    <name>A0A2T6ZST2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_66914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZST2"/>
    <dbReference type="OrthoDB" id="5372686at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="383" mass="41683" checksum="679898236BB56748" modified="2018-07-18" version="1">MSTEAPLRLYISPLTRPYTIPYRRAQTFDDFRTTANRILISCIETGELQAGCSESVPQPNNWNVVEETGAIVSSVLWQDLVVPGGTYCLLPRQEIATMSSPMRTSQSHSSNTESTATTRSRSTAAISSASISPVSSSSGSVSSVVSGNEIRGVSYRDALSTAAIGTGRPISESNYSFFGGDDESGVRLGSESPSSSCSRPAGKRDDDHTHTQPQPQDSHSMLTARSLVTSGSPWSAVVANGLSPQQSHHQTQQHNPNAHPTTNNNNNNPRPTAVNDWTLVQPRKLVAQPTIKPLVQIKVWKNETVPSSARSFTVPPTISVGEFIERIGGREGCRVQEMKRVREGFLPGLTYMWGTQKSIEDVGWADRKRGTVGVYLHMPPRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTS4</accession>
    <name>A0A2T6ZTS4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase phi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1108067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000105">
        <property type="protein sequence ID" value="PUU78873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTS4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTS4"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="700"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115063" checksum="F283FCC244CC4623" modified="2018-07-18" version="1">MSLHLYKPLGDNDHAIRLGAARTLTSELLQLLSSEHSEKSKSSLDYALGRLTKGLASGRESARLGFAVVLTEFLGHILEPGNAAKWGFELVGVIRLVVANTQPPGHTTGPEERDYHLGRLFGLKALVQSEILFHGVEGEGYAEVLKFLFELSVRKPWLRESCASIVCSAVSGWSDETKRWAAKVTYDALAGSGLAKTSDGVAVWLILQAYCPSVLPPKDPWAKECPLAKPNLVMLAKVLKEAGSKDEEGGNLQQKGSWSPKHNFVWDLVLEAYLGESEQWVDFREQEASALPTWEEFWKVVIDESLFSASSSNERKFWGFLIFGKALNRISALPDGGPYLGPMFSKNFMRCLINQLSDPERYLHKAAHKCMRALLQKAELTPWTVPVIFARLVSNSGTPNFGSLTKTKYVDKIMILADEDGLDAIIREFRKILLNPLGLKENSDSGEESQQRKTKVAEVRRQWVADQIITLIRNGKSVKAEVWIKSAVSLLAGFGFLEVPVRGAELGIPVSPASQAMFRSRLMSCLSHLLSLKDNISGDETWSYRAVKKAINSKDTLAIELDETIEIAIKNAQSTLKEINKKRASARKSAKAKRATQLESFELLYSFVVLQILSGEIDALEVLEELSLCYERVIKKRKHATGDEVDVSEVLVEILLSFLSKPSVLLRKLAQQVFTAFVGSITDAGLELLTNVLETKESLGGQQELFDKDDEDEDEDSDGVMDDGADDIEEVNVSASDEGEDSDELDSDVEIISASSASTSSQPDEDAADTGSDEAAKLEAALTCALTPHAPKADSDSDMSDGAMLTLDETLSNIFRQRTKPPSASKKRSEKAAKQNVTNFKVRVLDLLEIFAKADKRQKGEVRHDPRVLLLPLLACVRKTGDRAVAERCFGLLKICLRNPLPFHSAPPSSPPGREEEEEEEEERLWALLKEVHELAELDPGPAGKDRYAKACSTASLVLGKMLIGGGSEEMREEEFEKRVRRIVGAYAETLAKWVVEGGGVGVQRCFFVEFVDWVAGVRGGKSKGEVIGKGKGKGEGKRKRKKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU70</accession>
    <name>A0A2T6ZU70_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1082586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU70"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU70"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27220" checksum="D747CB11C3AAE779" modified="2018-07-18" version="1" fragment="single">MLLFGRMYLPTSTLEALYLKRVKPTTQFRITGVSDGRLKSGGTIMAMMQHDFGKWSGEYLYSTDGALIGARGLYNFGRDPRKQPNPPPRTSDEKAIGRFSMGAEFYYGILNKSAGMSTGLRYTTLPTHPNAPTTMTLTLTPLMGSLSATYAIKAGETASFCSRFDFNMYSYESDLSLGCEVWRREDVEKEDFAGVLKARISQTSGIGLLWEGRLKHLLFSVGAGIDLRRKDQLVRAVGLELQYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUA0</accession>
    <name>A0A2T6ZUA0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUA0"/>
    <dbReference type="OrthoDB" id="10508684at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015699453" evidence="1">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="31782" checksum="6633AA98262602CC" modified="2018-07-18" version="1">MKPGLSEVLSILILGRHAVAVPYGASDALSSAAAGIGQSQSLSTSPQVMITQIRTTETVEELVPKLGVRTAAANLESEPALEVAAVSPTLQLEHALETSIATTFTIETRTIITTATATFPTLSINLELSIPPGLMAANPSSPPHYFWEIDHWPEPLPYVHGQLTPGSLGSSSTKPHVTVYCLEESRYVYNLFNVTWIPTQNSFELCHKLEKALKKKGALILGYRCVEVPGWRNWEGGRERKMQATGARPLFPTIDLTAVLWEVFGGYQVWYEGRPKGEELCKLKYWWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUL9</accession>
    <name>A0A2T6ZUL9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">H-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_980423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000098">
        <property type="protein sequence ID" value="PUU79198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUL9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUL9"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037221">
        <property type="entry name" value="H-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019019">
        <property type="entry name" value="H-type_lectin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09458">
        <property type="entry name" value="H_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141086">
        <property type="entry name" value="Agglutinin HPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H-type lectin" evidence="1">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="106" mass="11789" checksum="8A4ED9734207D291" modified="2018-07-18" version="1" fragment="single">SAGAGWIAYPEDRPYLFSGTASTTEIRPSDKPRLKTSKAIDIRQAGFLKAPNVFMAINSFNLDHRANHRIKVEATHVTQNSLTWHIDSWGGSVLYDAGVSLLWFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVC9</accession>
    <name>A0A2T6ZVC9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.114</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1081776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.5.1.114"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.114" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVC9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVC9"/>
    <dbReference type="OrthoDB" id="2387925at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102522">
        <property type="term" value="F:tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF25">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="8">
        <location>
            <begin position="213"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="492" mass="53642" checksum="E32B7C8A60902595" modified="2018-07-18" version="1">MTSISLVVPAARVREVKVLLEERGFLAGKIRKVDESDGGGCCIPTSLVGGCPTSTTSITPSTTSTSDNGDGDDDDDDNGNDDGDEDGNADFDGEEKERIFHTLGIQDGRGITITPVTTITTTGTVTHDGRKINPPENPLQTAITAFLTANPPEDPTLLPTLLSTLPKRYTYTPPLLLLPSATFSTPAWQSYLSSLLPHDLQQNFYSTLIAAVCKTATHLAHLRPIPTQHNAIRAPKLTPLFGTFPPLLPPQQPPTRSDFDRALWTSTRQSGILQIWAPGYTMFSRGNVKEKARILRFPPPATGTRTKWAVDMYAGIGYFAFSYAKLGYRVLAWEINPWSVEGFVRGAGENGLPVKVVLPHQGMPVTMEQEQQEVVVFLEDNENAPARIAKMGEGVRGGIERVNLGLLPTSRGSWAGAIQVLAERGGWVHVHENVGIEEIDEMAGRVVKAFEELEKGRGGTRRVVCEHVERVKTFAPGVMHCVFDIRIGGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVU3</accession>
    <name>A0A2T6ZVU3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1081310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000087">
        <property type="protein sequence ID" value="PUU79592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVU3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="8541" checksum="202C0579859E9364" modified="2018-07-18" version="1">MVSSPEAEEEGRLDELWKLGILRSEDARALVIPPGEIRWMESALEYLRVWQSGLDGGRSAGVMGGDAKACIAKIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWF5</accession>
    <name>A0A2T6ZWF5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1124594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000081">
        <property type="protein sequence ID" value="PUU79815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWF5"/>
    <dbReference type="OrthoDB" id="5421609at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1173" mass="126808" checksum="9D60145FBB8286A9" modified="2018-07-18" version="1">MAPSKALSAKKAHALYREQKALFAQATAKHKIRMAEEAKLRSVDSQLEAVGENSSNGEPIVNAPVEKAIQEPVKSVVQSKAEAPKKVKAPKKAKAPKKATSETLSGARLLDSGFGKWEEFSPDDSNAFNVPATNTLEASQEENFSAQAASTNYRRDSLEVSDNSPVSHPAPAQADVQGPPFNSTNNIQDLLGSLEFPPIDDSSISLNNSDNISNNSAGDSPDWLSGLVSPLNNFPLNQVPTDREQLGAGVAYEDIFGIPVEEKSESAVITSVDGSFNSTNTLMEADDNSFDSIASFFCGDGNNNNGTVQGEGAPISYTALLEDFDMSSAIDPSLFTPGNSSHLSLPDLSTGQDGNAQEPLSGFPEGEGGCDSDIANLIPSDDSKDLDYVDETPTPCQPSGQVSGDDHLMTETAPAANYPQQPQVQLENDQSQSDPVEAEAEGVRHISKIAHPQARMIGPDANLFCYKCLHPGHKTDAIACPVGRVESLMDPQKETFYIRLDAVLVRQKLLVQDLRWIAEGLNWGIDMAEEGVLDGLGILPSSLLYLKDLLTSWKSASKDDEYTFGPLSGVQLMYGEEVVIDETQQSTAGLYKVTKSHNVKEVSFASLIQGSSAPPRKRKNTSDKTVAELLELDCIGARPKATCTLCFYPGHTSNSTVLCPFGRIESAVIKARKKKSWKVVDLDDEVGKLKRVIDGLGEEDERTGILIDMLEQWEHFSRGAGAPKSKPKKVYARSGSNPKGSSLNTTLGGNAGADNSASLGNSSSLLPPGPGIGSPKSSNSSNTSAGDLLNIPVYINPPRRSGIKTIGARPDTLCKECFYTGHDQRSQACPANILRRALFLGTLKDLEGTGSSCQDISDILAWEASQPPSMKADNTLRQKLEMLHTKFITTWNLLDAPQVGTNSRDQYASNSRTEVPGTPKKRSYQHASFGKQITPPASLHQTPLPQGQLESPICFKEAPLSGICIDHSKLGSQMLMELLPFVINGQETRGLRVDHTKMSPQLVMAIAPFMIADTPLIQNNSYQDGQRKESRKSPEQSSPHCGFAPISNHGGNNFPGQSQFRTSTSAFPTPPDTMADFQGAQYQPGEALDTPENLGVTLAKSLFGKNGTVPFGDRFYCEKSVLSVLNLKEKDHFEEWATVNTLGFQIEPLLLRPNGQKEYYLSSKTRSFDPSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWM1</accession>
    <name>A0A2T6ZWM1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1080578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWM1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWM1"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="273" mass="30832" checksum="612911C743F7105A" modified="2018-07-18" version="1">MSTSQPSGEPHRPKKFPTQEQQNNPYLSMFNHFRDELDEHHDRRERVIKASRDITALSKKMIFTVQRAREPFSPLPTSLSKEYETRFKQVQNIISIVSPDLQEISTYRYARQISGGIQEYIEAIAFHHYLTTGKLIPLSVVQQSVKHLVEITPGDYILGIFDLVGEMMRFSITMIATRGGAEKDEKVAKALRDLRELRLEFEGLDTTLGGGSGLLGKEVQKKLGVMKTCVEKVEAAMCGVIVRGSERPRGWIPDLTEVAGGRGGRTDRIDQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXL6</accession>
    <name>A0A2T6ZXL6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1080003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000071">
        <property type="protein sequence ID" value="PUU80206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXL6"/>
    <dbReference type="OrthoDB" id="5394790at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11736" checksum="9F26F895FC462C0F" modified="2018-07-18" version="1">MAPSMISQPTTPPIAPFGYTKAGKPRKRPVRNKKEGVCPVKECQRSFKHRPNPKDAIWQHLAYYRSPMCAEPSSSPFRQAHITMHQKMKAESQSKRLSGINIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXP3</accession>
    <name>A0A2T6ZXP3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobB/CobQ-like glutamine amidotransferase domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXP3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXP3"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="233" mass="25792" checksum="960EBC261B1F9C28" modified="2018-07-18" version="1">MEDDEILKYLYYIGVVKTRDDQTISIDHDGDMTYCTFALLEERSSRNGMKPPTQWSVCVTTPSALTRNTRTSSTMTMGLTYTLSFTPSDLLFTTLLNYRPRVTILREQGVNGHAEMAFSFKLAGFTPVDVHMADIIDGRVSLSDFVGLATCDGFSYRDASAPANLSSCTRKPDRSLKTSSRLVTTPLHGRKFQPPNCLAPSAFLNGMHGVRFHADRYPYNPNRSPGGSPSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYH4</accession>
    <name>A0A2T6ZYH4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1063374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYH4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYH4"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000995">
        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF77">
        <property type="entry name" value="SERINE THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="472" mass="52769" checksum="7940AD88E15168A6" modified="2018-07-18" version="1">MPPAYGRSASEIHRQAEAGNPLYLIREEIAILKKLDHENVVHLIEVLDDPEGDSLYMVLEMCEKGVVMKVGLDDTAEPYPEEKCRLWFRDMILGIEYLHSQGVVHRDIKPDNLLLSKDDVLKIVDFGVSEMFEKKSQMLTAKSAGSPAFLPPELCVSGHGDVSGAATDIWAMGVTLYCLLFGKLPFSHCGVVQLYESIKNDEPLIPEGLNPDAADLLRRLLEKDPCKRIKMPELREHPWVTRSGEDMLLPEEENTSEIIPSPTPEDVASAITRSIRNVMAVVKAVQKLKRLTLKRFRHPYLSAKDAPLSIDDLPVRSKSYDWDNLKHLEQKLAVSGVTKDMSVVSISQTPQKPNSSAAGNEDTEMADNIQRIDVECHNFGISETVDSPMEESPPFFDELPKGQPISPPDEELHFLQVGVGSDQPAEEASRVISESPPPTEENVYAEAYREDAARIMEERGQSATIYLTKWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYK5</accession>
    <name>A0A2T6ZYK5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_726126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYK5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015395452" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10494" checksum="F000BF9E4CD35AC9" modified="2018-07-18" version="1">MISFLSFFLSFFFFPYYDSTMNTRPYLIHTLAQYNNTRNICMHCTTVVTCSTCPRQEVSGKQGFARHMAKNPCASQIHHSYSRILLARDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYM8</accession>
    <name>A0A2T6ZYM8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1100179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYM8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYM8"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="601"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU80599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="989" mass="104867" checksum="30F56F6FD85E1EB9" modified="2018-07-18" version="1">MPPKEPKDSPTPGGARLSRTSTRRSTPVGTPTSTKPSGQTLSSVQPQASTSTSTAQQEDTPVNWSEPPLPTPKASYKEYDDKASVNTSTQHMLPLGELPKMEATSRQRPSQPAKKRKGGKLVVSTPVPAATTPTAVSSPAAAMEASASPANAGVSASNVKSTNGTGVVGTIGVGNEGVGGGGAVQGPLTSGGTPASASAIPAASVAPVRPAQTSKAKPDVSSTPVVTASSPAASLSRSPGINPQTPNSANGARPSTTAPSNVWINGQAPNSKTPQGRHRLEMVVDAAIERSTQIGNLGLGRAIKKLYDESLSNNLLADLLDAVLAQRATPAQEPVVEVKEANGSTSSSSATATSAKKDKVEKEKEKKEKVDKRADKKDKRKNGVKRTRGAKDQGNKVGEESESDLSSVSSELFDERAKPEGASASVGSHPDSSHSSPAASFTPMNQPTPRPKGTSERASKKSRKGVPADDEVRTESNVRDPPPPPIVPRGTRATATNPRKRARSLSTASTPPPAGSNSASSNTPSASGAASGSGSGALGTPNMLPTQPPKKKPKGNKIKISLRVSPVKKPAAEPIVVTAGIGDLSDNRRVRYGSEEVSENEDVCAVCNGPGRFLCCERCPRSFHFTCLNPPLEEVPEGMWFCNKCTTQHNPPPKPPRGLFVDLIDNINRRNPSSFRLPSEIRNYFVGVETGPLGEYVDVRDNKTQRFGRSGFLEEYDTHRLKDKSGNIILCHSCRKSAADGQRMISCDFCPLNWHLDCKKWMCPAHADMYQPRRPKKAVIVDAYLRRGMKNNGVIEIENEEEETFEEVLISGVVYRLPERGIKLDFIEKIKNERDYAQKRRKLDINVLGNGTPVPQTPIANLTSPIPIEGVPGELQATVHSLIELSTKERLNGPLDPNGLGGLVSVLIEKAPAGVKALLAEKSLILPNQPLSPAASLDTALTPNTLEIEKRQLQALHELIARRIGVIDGSTLPISPAVPQSHLTVAESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYT0</accession>
    <name>A0A2T6ZYT0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_974143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYT0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYT0"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="53"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="286" mass="32061" checksum="1F1DB70DC00926C6" modified="2018-07-18" version="1">MDTDNQFGLNDHGSSSVPNEHTITDEGKDIFSWLSTLEPQKQHSHVSHSRLKGVGGWFLETAEFRSWRDDDSEFVGQILFCQGVPGAGKTFISSLAIDNLSEISDPARAKIGVSYIYNDYRNQKYQDSAGIMGGLLKQLLAGLPDMPEEVTQAFQEAKECLGGQDSLLPTILKLFPSVLASFGQVFMLIDAWDEFSADTRFMLFRSLRQVTQGSPKTRLLLTGRSHIRPELDEYLAKPTIFVTIQPTPDDIEMFSRWKLGQDLVPDSMDGDLRSEITAQIHKLPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZX6</accession>
    <name>A0A2T6ZZX6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZX6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZX6"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="56"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="371" mass="41774" checksum="5A7654BF2A52ED09" modified="2018-07-18" version="1">MSRFHITTHVLAASHLREFSRGTISAANPPQLKLAVNQYAPRSNAGIPAQSGDVTIIFCHANGIQKELYEPFFDHLLVEYEKSGLRIRSIWALDAVHQGASGVLNEEVLGDDPCWNDLCRDVLHMVNQRPQDFPPPIIGMGHSYGGHAIARISFIHPSLFTSILLLDPIIEDNSVFPTPHPSTRSAKRQDVWPSMAEAEKYVRSRPFYTVWDPRVLEIYLKVGFRPLPTLTYPNKTGVTLTTTKHQEVYTYIRHDKSFQNGAQLGRDEPGGTLRLMSLVTPPLMYLVGEKSDSWAPHLMKYKMQLTPGATLEIVGKGYHLFPLELPAKSAELAAPFLIKSIKRWGKEAEKDLATPRHKVLTVDFHERLSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0D2</accession>
    <name>A0A2T7A0D2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1122482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0D2"/>
    <dbReference type="STRING" id="42251.A0A2T7A0D2"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="463" mass="50444" checksum="1B999CD876D43314" modified="2018-07-18" version="1">MTHDQIIGTYVHIPGKPREQHALYMLRRIASLVKPIMSKGGYKVGCLAEFYPAQKNLLGLNVNNGEKVCIRLRQPHDDSVFLDVEDCVYTMLHEITHNLHGPHDDTFYTHLKTLEESYSALRRGGYDGEGFYSEGKRLGAGIPKNPMMSEARQRALAAAERRREIYSGSGQKLGGGKNPLPGGLGIREKIAAATERRIRDSQTCGAGSGAGDRGAMEAEAERTIRAGTVTVDKEQGEGGVEQEVIVLDEDPENEAAIIKAAIELIQEAEREEAEQKLLWEERGGIVWIDGDDGPIPVELPPTTTTTTTTTTASAPPLPSPRIPVPIIIPSSSPPLLPVEPQDLPPSYEQATTWTCDLCTLINPSILPHCEACSFERPEDTDTVTSPPPTPLSPIYQNPPLAQAVIAGKEKERERLKVRFADMPLMIPEKNEAAAAGWRCVGCGRGNGEEWWGCGGCGMVRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0K9</accession>
    <name>A0A2T7A0K9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_1062759</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0K9"/>
    <dbReference type="STRING" id="42251.A0A2T7A0K9"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <sequence length="959" mass="101433" checksum="ED66592A0B5EB5AE" modified="2018-07-18" version="1">MSEVQTRPPAPRGRDGRGGRRGFVPRGSRVSGGGNASYDTFDDQGEIGQLKRQYAGELSQLQEMFPAWTSDDIVAALNENGGDVQLTASKISEGTTAQWGKVEKKSKDRSRSKVKEPSSVEASIDSYSSSPRTRGNRVSHEGGRGGHRGRGGSGFHASRGGRSRRANDDNKTADSAFPAWTEETNKETEANGAFENSFAPDIHSEASKSTPDQAPLSVPRPAPVTSWASKLFSKPAPPPPAPVQKVPSPPKQPPVQPEPVQQPVLEPQEPEPVEESLPPPKEPSPEVQPAPATPEPVEPTPEPVEPIEPVEPEPVPDPEEEAVPEVPEVKPPPAQPLTEVNLGKINDATLPPLTMTQASTIASSTATPAATTSISAPPPQPTVTTPQPAPSRPVHSGVVMPKGTPGRGSGYNRRVLDQQEGVVMPGNHGAVEHTTLQFGSMGLNGDTEDEEEVEQAETVSQPPQPSPIAQPVTSLPPTGPSQLPVSQPPATEALPTPRQAPGLPLHPQAVSQQPSSQPPVAPQSMTQQHQLNSQLPGHYNRYAIPETQTQTKSFDAFAHSAQQQSIPPHQPQAQTQPQAQPQAYGNYAPSPLQPQQQPSHIGIGVSAAPDQQPQYNYYNDRSQPPGFGAPYTSNYMQQAQSQQDAGTNQQRASSGLGGAAGEGLGQVPTSVGTTSQVQQQQTSRYPGQTGEQGSGHATPSPAIPTVQQTSQPHQPVGQHPTQAFQYGYQQHPYYSQFVPQSYYNQPFKNHQGMYGYPPTYISPQYSDHTPTPAALSGFGAPSAQGRDGVAGLGDYSRMNTATAQQQQQQALPQHTSTGGYVSSIPNFLSGRGLPQEQQQLGAGVGQQQAGQQGQTDESLKFGENKPPTGPSGTPSIPGQPGRPGSATSNLGPQHGGQTPASMYGSHLNHGLHGHQPQSQYGVGQGQSGTNQYSMYSGSYPQYGQASGRHAGGGWGAYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0R0</accession>
    <name>A0A2T7A0R0_TUBBO</name>
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        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase spb-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1077273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
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    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU81329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="848" mass="95630" checksum="BBD0C03511756BF6" modified="2018-07-18" version="1">MAIQKKHGKGRLDKWYKLAKQKGYRARAAFKLIQLNKKYNFLEKSKVLIDLCAAPGSWCQVAAECMPVNSLIVGVDLAPIKAIPRVITFQSDITTDKCRATLRGHLKTWKADTVLHDGAPNVGIAWVQDAFTQAELVLQSLKLATEFLIEGGTFVTKVFRSRDFNNLMWVFNQLFTKVEATKPPSSRSVSAEIFVVCRGYKAPKRVDPKFLDPRTVFEELPDPAPNNEAKVFNPEIKKRKRDGYEEGDYLQFKEVPVNEFIETTDPIQMLGSLNRLSFKEREGSDLATVAISKMPETTKEIRHCCDDLRVLGKKEFRALLKWRLSVREKFDLAVKKANAKSEVTETAEITPMDEEMQIEEELERLKMKELGEKKRSRRRENERKQKEIVRLQLHMTTPTDIGLGQDAEGESMFAIKNVDRAGALDKVTKGKMNIVVEEDHNRPRKDIHMGDAPEDDSEDETADKLEAELDGMYEQYKEKKAEADAKYKAKKARQEHEDGEWEGIKSDAELSDDEVAIDAESSEGDDSEGEDNESEPKKLITHLDGRDITGEDGLSKKAAMFFDQEIFQGIAFSDLEGEESEEEAEEEDEAEEGEEEAGDDIEMEAYSVGKPTGTRHDGSEKGTDDSFGIEEEEGEDTGIEIIKAQKDDSWDAEEEPIKNGKLNIDIITAEAMSLAQRLAVGKSSAKANIIDDGFNKYSFRDRDGLPDWFLDDENKHSKPNRPITAAGAAAIKEKLRALNARPIKKVREAKDRKKFKAAQRLEKLRKKSALMADEEGTTEKEKAANITKLMAKAGKKKPKAKVKVVVARGPNKGQGRPKGVKGRYKVVDARLKKDVRAQKRIAKRDKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A189</accession>
    <name>A0A2T7A189_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_971693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A189"/>
    <dbReference type="STRING" id="42251.A0A2T7A189"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="532" mass="60354" checksum="6015F8D6EBB51CCA" modified="2018-07-18" version="1">MGIFLRLIDYAEGKSLHGYPLFSAALALLFLGIFLLLKKEWSIHGSENFPIVGIEFPGYFGLLKARARFVSDAFHIVKDGYHKYKGKNFLVTTHGYDKIILTYNQVQELSSAPDDAVSIQHAVVETMMGQYTGMDRFVGTTYVQEAARIKLTQNLGTIKDAMIEEIRFALDTELPECTTDEWRSIEIFTTILRTVARTSSRAFVGLPLCRNEDWLTVSMKFTGDIFMTVDKLSSIPKLIRPFYAWIFNSARLINSHRKKAQTLLGPIIQGRFEEERLAKENGTIYEKPDDMLQWLTNLVEPHHKNIEDLSELQLLSNLASIHTTSLSFLNALYDLAAHQECVQPIREEIEAVLSANNGVIDKAALRQMRKTDSFFKESTRETLGLFSFNRKILKSFTLSDGTRLPEGALIAAPVAMFATDPDLLEDPETFDGFRWYKKSLEAEGRATHNANWTATSAKDLAFGHGKHACPGRFFVAEEMKILLIFIILQYDIKYPEGQSRPASLKHGEFFFPDTAKKLLFKKLPGPKKFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1D7</accession>
    <name>A0A2T7A1D7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1076744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1D7"/>
    <dbReference type="STRING" id="42251.A0A2T7A1D7"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="519"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU81537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="701" mass="76020" checksum="2435384B3849A443" modified="2018-07-18" version="1">MKAKTYSALQKTYDQAYLTRSIAVHYDGQGNEVEALRCWRECLGQLQGHNSAGYRPRSETERALLRSLKAMQDQCQERSELLQALLISRVEAENSGQGWRTRDAEPVTSNPQAAGPAGNVKPAISPIPPPPLPSLVPPRRVPVSVSSSVRVTSRATTPPRAVAPSSLSRTPSPEKRAFLSTLRPSRKLKKTDSRNVNDDPEAAAKAATLAATLAWGSRSRAEGAHLSRTMTEPSADSLPVRQSFVASASTNDVLCVQHASTFTVNWRPGPPPAVQPRTGLSKIKSRPHSSILPLGGPPYPEDSAPPAPPPHGYFPPSSKNIRSSHLPYPELPQALQPPSENAFRYSRTDAQSAQTPPPRVPPKPIKSERLSHVDDAKPVVPTPEPEPKGDSDSEYYKPPTVVDSRSTIHSPATSEGEDKSTAPPTPPPEEEKPITPTGGEEVPPLTGNTLDERVAKALESLGKGVDMNAAMQVANEIVVKGDEVHWDDVAGLDAAKLALKEAVVYPFLRPDLFSGLREPARGMLLFGPPGTGKTMLARAVATESKSTFFSISASSLTSKYGSLGESEKLVRALFALAKAMAPSIIFAAAGKKLPGDASRVLVLAATNLPWAIDEAARRRFVRRQYIPLPEDETRKKHLQNLLGHQKHHLDDGDMERLIELTDGLPITFEDFEASLKSIRPSVSKEGLQVFEDWAKRFGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1L7</accession>
    <name>A0A2T7A1L7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1076593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1L7"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="20364" checksum="A8A72BDD02C9DCB4" modified="2018-07-18" version="1">MPSQALKIPTPTFNETPSAQALISALSLAPHPEGGYFKRTHTNPTTITSPFPGQIDATRPLNTSIQYLLTTHSPIGHFHKNRSLIVHTAVRGRGRYVLIHESGKVETFVVGCDIEGGEAVQWVVEGGVWKASMLEEGAEVLLITEVVVPGWDASDHEFLTKGRLADIVGSEVAEELSSLVRSDDQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1N5</accession>
    <name>A0A2T7A1N5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cryptic loci regulator 2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1076628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1N5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1N5"/>
    <dbReference type="OrthoDB" id="2421327at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038986">
        <property type="entry name" value="Clr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031915">
        <property type="entry name" value="Clr2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38046:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16761">
        <property type="entry name" value="Clr2_transil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cryptic loci regulator 2 N-terminal" evidence="2">
        <location>
            <begin position="109"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="221" mass="24926" checksum="219B609D94DCD52A" modified="2018-07-18" version="1">MPTPKQPQNSPDFLLYTVYVPPIEPTPVLKMPPTKEDLLLVALTWSDGVRKFNPPSMDRDPCSDADFYKPIRRSDDKALDWLSQLGVWPNGLKDSLFRRKVGEGKCIVFELPDGYSLYEKVHIPTKVPHPLISLLPLTLPCFLFGHPSGEPFKSPGDFRRHYLWMACDPLKDPKNCKCRLCLKDRVKGKYAVPVREPATVSTVSTNPQSSVGSWGSVSSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2A6</accession>
    <name>A0A2T7A2A6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000038">
        <property type="protein sequence ID" value="PUU81861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2A6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="13396" checksum="B3E47E57E494C830" modified="2018-07-18" version="1">MAPRPIVNLDATSPINRLLSAITSIFEFISSSRPLFQSEGADGIVIMDSEVPSIPITPLTPSRLPVPTGFELKPPGPEKESWMGIQVLQDTDEYTELTSNPWSEKRKRSSTFPRPQLRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2D2</accession>
    <name>A0A2T7A2D2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1121560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2D2"/>
    <dbReference type="STRING" id="42251.A0A2T7A2D2"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="384"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="521"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="572" mass="63857" checksum="7A75A1F9497B3D8F" modified="2018-07-18" version="1">MSSDKLKAEGNAAFKAKDFDKAIELFTQAIEVDPSNHVLFSNRSGCYTSIKDFDGALKDAVKCIEIKPDWAKGYTRKGAALHGQGDLVGALDTYEEALKLDPNNAQAKSEIKSVQEAIARESQQDGAADLGMGNLFKDPQFLEKLARNPRTSAYLGDMEFMEKLEKIREDPNLIQTELRDPRIMQVIAALLGLQMEMGDGSSGPGGAARSSEDTEMPDASGAPPPKKAATPPPEPENEEAKAKKEAKEAADKEKALGNENYKKRNFDAAIEHYNKAWELHKDITYLNNLAAAKFEAGDYEGCIKECERAIEEGREIHADFKLIAKAFGRIGTAHQKLENYPAAIDYYQRSLTEHRTPETLQKLRVVEKIQSDRDRLSYIDPEKAEEAREAGNAYFKSADWPEAVKSYTEMIKRAPEDPRGYTNRAAALTKLMSFPEAVKDCDEAIKRDPGFMRAYIRKAQACFAMREYNKCLEACNAAAEADTENKHTREIEELTRKAMQTMYSAREGETEEQTMERIQKDPEIVAIISDPVMQSILQQAKRDPAALTEHMKNPVVRGKVQKLMAAGIIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2I5</accession>
    <name>A0A2T7A2I5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_511906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000035">
        <property type="protein sequence ID" value="PUU81957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2I5"/>
    <dbReference type="STRING" id="42251.A0A2T7A2I5"/>
    <dbReference type="OrthoDB" id="3552069at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF127">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="276" mass="30777" checksum="920657FCD166A765" modified="2018-07-18" version="1">MNFIRLPAELQLLVAEGLEPRGLSYLSRTSRYFHSLCTPVLERGAQEPIKSHCALEWAILRNKLPLAQLLLSKGHDINNMGSIYSGTALHVAVISGNYSLIPLFLENPALDLNKLDGDEDTALHRAIWWGNPEGVELLHAAGADLEIPDKRGRTALLLAILYCDMRIIEFLVRNGANVNARLPAGTWLLDVTPLHGLMWPNCERLVRLALEYGADPEIRDHWHQRPIDIAFMNGLTGIVEILREVSLPLDIDVESDLETVWSDSSSGLRGINMRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A310</accession>
    <name>A0A2T7A310_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1075613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000033">
        <property type="protein sequence ID" value="PUU82133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A310"/>
    <dbReference type="STRING" id="42251.A0A2T7A310"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF121">
        <property type="entry name" value="ADA2A-CONTAINING COMPLEX COMPONENT 3, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU82133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="18974" checksum="B4AEF85DBED56EA2" modified="2018-07-18" version="1">MAEILLSGGADVARRNRHGLTALHYASGDAKLLELLAKRAGKEVINMKADVGGYTALHCSVRNGARPVRVLLAHGADPGIIDSSGLTALHLAAGIGSIDAIKELLGHVDVGVQDHGGCTALHWAATWENLDAVRTLVEEGRSPLHLKSRMGKTARDVAAEKEWMDGVKYLERMAAGCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3M7</accession>
    <name>A0A2T7A3M7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000030">
        <property type="protein sequence ID" value="PUU82328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3M7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="60" mass="7145" checksum="ABDA9EBA608BD8D5" modified="2018-07-18" version="1">MIKMQPLRVFNFLLVFFMMSIARFPRFLVHILALLDFYIPTRVPVLSLLPCVIYCYDSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5D1</accession>
    <name>A0A2T7A5D1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_279783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5D1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="158" mass="18480" checksum="90FF481081860B76" modified="2018-07-18" version="1">MIAAFLHRKCFPERPSTHPNPKQYAQIRSPFLKTNPDPQPWSYGRIPNAFPKTNPCPKSKPYAQSSHRISESYNCIVLHIPCSRMLIWIHFHYSLSYRYRPLRCASPPSRVHPASTQMQHEYNPPMIPLLTLHPAKAILRLTHLSHMTTKQFRSYYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5I2</accession>
    <name>A0A2T7A5I2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_934969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU82994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5I2"/>
    <dbReference type="STRING" id="42251.A0A2T7A5I2"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="105" mass="11559" checksum="F9CFEAE713F64F19" modified="2018-07-18" version="1" fragment="single">VQLLLDTGHSYNQKNVFAQTPLHIAAANGHHCVVQILLEAGTSVDALDDYSWTPLQCASRNGHSSVVRKLLEWGADVAQADDFHRTPLHWAAANGHERIVRILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Y3</accession>
    <name>A0A2T7A5Y3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Y3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7346" checksum="2A5B01348852998C" modified="2018-07-18" version="1">MPNLCPLFQEALAKELGARSKFWVKERSHYKKVQMPGGFGKRPARSRVSCNLLKQILKVFLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A707</accession>
    <name>A0A2T7A707_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyridine nucleotide-disulfide oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_963532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A707"/>
    <dbReference type="STRING" id="42251.A0A2T7A707"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="45"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="7">
        <location>
            <begin position="423"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="485" mass="53863" checksum="4931BE5BE31FCBEB" modified="2018-07-18" version="1">MATILRGDILVRGASRRVAICGGSIIQRRTFSLQELDEKKGSRERVVILGSGWGGFGLARQLDLKHYQPLIITPRTYFVFTPLLASTTVGTLEFRQAMEHSRSRPGTEVIRAWAEQIDFSEKTIIVEGAVQSKDKVGSIIGDGKKFEVKWDKVVVAVGAFSQTFGVEGVKDHAFFLKDVADARAIRRRILECFEEAALPTASEARKKQLLHFAVVGGGPTGIEFSAELHDLLSDDLTKLYPSLAKYHRITVYDVAPRILSMFDASLAKYAEKVFSRQKISIKTSHHVHKVTSEAVHTQEDGEVPVGCVVWSTGLAPNPFLTKALKGKLYLDERSSKIVVDDHLRARSMGEKSSASCPLDDVFAIGDCAIIGGQELPATAQVANQQAIWLGKTLNKAAVRKAARGKPGPVKLQDEKMFRFRSLGIMAYLGGWRAITQSGSAELKGRMAWVLWRTAYMTKSVSWRNRILIPTLWFTNWVMGRDINRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7E0</accession>
    <name>A0A2T7A7E0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1174143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7E0"/>
    <dbReference type="OrthoDB" id="5299910at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="81" mass="9183" checksum="0F0876B2D9F6AB55" modified="2018-07-18" version="1">MMIYPIFVQLPLPGEQFPPPGTTRKLIKSCFSEGWDRIQKGVLPACKAKQCVARFKPSLSRKDAKIKRKQVTCCGGKYIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7N5</accession>
    <name>A0A2T7A7N5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1112315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7N5"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58736" checksum="732826853EEB9E48" modified="2018-07-18" version="1">MAFNLTTRLSDKYPNAYSDFYGSGTPCVFKSGPNWHVPKGPQAQGIKREARPVYRHAIGPTWLTIGERIYLRLDSIGVQWTSINPLAYADTGEAKPFCSLILSIGVKPYSLLYDAAVAAAAAVKEILAEAGFPSIEVAFVESVVTRSVAAGPKLLSFDPVLDDVPDLRKPFTTALGLSIAPLKYPYFEGTAALYFRLSKDDTRTAILTCAHVARPPPIHANMGMIRRNTSQPREEFIALGNIGYNNAIKAMMGTIGDRLHSIEISNKVLGRLGEPVEAENKKVTQRRKEYMQLVEKATQEIKEVNALHDEVTKRRTTPDQRVIGFLLHSEKVEVSAAPHGFTKDWALIELYNEKIDWSTFNGNKVYVGGNLTPADFCNTMFPQVVDQADYQYPLDGLLQAYGVVLDDEIRNPQHLDVHGEKCLLVVKNGLTTGSTVGRANGLESFTRTYTDWGIEQISIEIAVLTYDKTRGKFSAAGDSGSIVLARDGRIVGILTGGAGPTDETDITYVTPYWWVEQQIKAKYPGCFLYNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8B8</accession>
    <name>A0A2T7A8B8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_649962</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8B8"/>
    <dbReference type="STRING" id="42251.A0A2T7A8B8"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU83963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="506" mass="55737" checksum="CB0DD486E7AD34DA" modified="2018-07-18" version="1">MADGQTPAYSRKTNSSDERIHDMVHSPSSTSTGTTATPSIYSPVTLGATAKPTRATAKKKTSTSPKVTATTSQVTMATISTSSLKDGTTPTQRVSRAKKGKRVHACNHPGCDKVFTRAEHLRRHQLNHSTEVFYKCEMCERTFVRQDLLSRHTERHATQAMKAVQTLALAQRHTGFVTRYGINGINGISARPPQTSDYGGNAHVFDSNPHPSPRVHTDVNTLPQILTSHSPHQSSPSTTSLGTPHSSTSMASYGSTFSTTMPLSSHGMESSLDYPSGESTSSPSGNLRRAHLPFHLQHSEPTRQPEPFIVTSHPEILQRPPALSIDSQLYAKPMPTWENYAWLFDDSTPQDQALIDMNRNQDSLHYLNPLETTHYRNLAIHGGGGGSGNNSSDRTAYENVKSESTLAFHPIDERMRSQILMMLGNVPNLHSSAYASTSSMQYYLRLYWTKFHPIYPVLHRPTFLPGMQLVMLVAIVIAIGASFADDEAHQFGMALYDKVKGLILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8S3</accession>
    <name>A0A2T7A8S3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_961494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8S3"/>
    <dbReference type="STRING" id="42251.A0A2T7A8S3"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="13107" checksum="C36FF15CEE6460A9" modified="2018-07-18" version="1">MFSAFRPTQSRLGGLLWKSPWRLSSNQKYRHRQRLRRVDRIVDVVDKALAKQGMTATAVERWKSEMPTEAEMKPRDKYTMFDPKQKSYRKGVHKLPKWTRMSQRVNPPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9P0</accession>
    <name>A0A2T7A9P0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1070269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9P0"/>
    <dbReference type="OrthoDB" id="5413994at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24426" checksum="B5BF3A21A8D3918A" modified="2018-07-18" version="1">MAEVVEPLPSPPDTGPTATSASAPAAPSSPNTTQHGRVDIASSPSSRAAPPIPTITSLAQRFQNTSELNSHLLSLSKAELAAIVMSEAGKSSTTTTTTKPPTPESNKYAHCVYCHEIFDKEYNVGCQVKHYGDREEVDYDSDISKLTCCGFSLDHTEYDECHPAPEEAEPYCYEGKHWDRFIDQGDDERGIWWQEWEESGRTCKDMGCRGMVNPKKRRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9J9</accession>
    <name>A0A2T6Z9J9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TRAPP II complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1111876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000739">
        <property type="protein sequence ID" value="PUU72149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9J9"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9J9"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU72149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="264" mass="27951" checksum="B4E514D1007034E2" modified="2018-07-18" version="1">MRTIMCDITSVLLSELSGLTRTIQAFPTIDSPLSSENQAASASGGRDHRMSMPVGLGANLTVAGNTGAASKRMTMTGFGSASVSERTRNKGKGRVNTVIASLYLLGGRVPDALKEFVEGGNIAKNNNDHLWHGKALEGIGICLAILVHLKVDFQVPSIPYPTVEVSKTTKSSPSNSKPVTPSPDPGGVPDTALSTSSAKINELLGELLEIILKLYRLSANFAGESIPQICFSETVIRFSKLRATAYITGGLLFLACPKRLHGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9X8</accession>
    <name>A0A2T6Z9X8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_704291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000592">
        <property type="protein sequence ID" value="PUU72297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9X8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="55" mass="6624" checksum="9AD8985ECDECD56E" modified="2018-07-18" version="1">MWKGELLACILLLYKVPLIPLSADKEYTTRQQHNNTHIYCFYWAKFYLLLLFLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9Z8</accession>
    <name>A0A2T6Z9Z8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1097507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000578">
        <property type="protein sequence ID" value="PUU72317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9Z8"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9Z8"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="315" mass="34472" checksum="E4F5E143719D2C98" modified="2018-07-18" version="1">MSIPQSEIPRLSILYHAKRLIPSSKPPQRAPSATLNTRVGLIRGDITKLSLPNGAIVNTTNTSLLNAGGICGAVHNAAGRGLLAECLTLNGCETGDATITGAYELPCRNVIHAVGPVYWKARKTNEHASLLASCYVASLRLAVENGLDVIAFPPISAGVFGYPSYEAAEVAISTVRDFLERGEQEGGAEERRLRLVIFCTFESKDEIAYIELLPNYFPPADDKEGSRKSPEQKTPEEVKTNFSCFSAPSPFAAPTLHKDTLRISPKLKETPGPQDPNRHRYHHQNQQQQQQHTASAPDDHDEDEDEFVLVTGELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA52</accession>
    <name>A0A2T6ZA52_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_687905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000565">
        <property type="protein sequence ID" value="PUU72349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA52"/>
    <dbReference type="OrthoDB" id="5480757at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="160" mass="17487" checksum="807B4D73B15DC9AE" modified="2018-07-18" version="1">MMSQRMHGAKGDVSTSFRQEFMSAIETTGLSENPSSDLTLPHSLVKGFTDTPGPGRREALGSEDKDIGIPDNVRERKEFVCMASPDQYPFGSGTEDTSESSEAGKDGRIEDSGTTFIMREGGARRREHEAGPSGTREDEGEMVMLVELCFCVANKTNIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA77</accession>
    <name>A0A2T6ZA77_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1010288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000550">
        <property type="protein sequence ID" value="PUU72398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA77"/>
    <dbReference type="STRING" id="42251.A0A2T6ZA77"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU72398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="194" mass="21058" checksum="878DE52B751C5FFC" modified="2018-07-18" version="1">MAPKVLFVLSSHKVLGETGRPTGWFLPELAHPYHLLVPHVTIDVASPAGGEVLLDPNNVEMFITDDIAVKFLSEEQQLWKNTIKLENVNAEDYDGIFFVCRHGAMFDISCAPIVVSLIKSLADANKLVAAVCHGSAALLDVKLSDRKLFVDGEPVTAFSNAEEDAMDLSGAMPFILETDLVKNAESLVSKLTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAF2</accession>
    <name>A0A2T6ZAF2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1197583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000547">
        <property type="protein sequence ID" value="PUU72404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAF2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="29925" checksum="103230D90B054F04" modified="2018-07-18" version="1">MLCLSRFQSSGRLALPPLARHLRTITASNRNLSITAYKREGGGVQPEIPEGKQGSNKYEPKTEARLEARPQPGPNKELQRLDDWWLKYSQEQKQDLQRKSAEIQTLTAALMREKAKRVREERHVELYKAIEDIVWVAKGRIDDKGLRVVSLWNNHELGLYELSRHPEFTKVLREEVEARGLVLEDVDTCVREIYWDLLPSPPSYDRDETIVIRDVDFTAEQRAALVTFMKVLDKWEFPWSWREEISGKAREENAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAG4</accession>
    <name>A0A2T6ZAG4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1104378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000536">
        <property type="protein sequence ID" value="PUU72436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAG4"/>
    <dbReference type="OrthoDB" id="6577359at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="452" mass="50994" checksum="8E2849061E2B66A3" modified="2018-07-18" version="1">MASIPESRHRIRDFISDLPPELSRLILSQLEIQDVFMCAAVCRAWRSHTRINDSLYIPHLLRKYNNITHGRNPIPPRANASQELLQRFPHLSASPYFCNPKSLRDLALRDMRLQRKWESGIPWRKANLNSCMKHNDVVFSVLIDQVYSLIVSGDRSGGVVFWSTRTDEMIKKLNLAQEPGEDVPAISPAISAMALEGDHLVIGTWHMTVHIARRDGKGTPIENRAFSLVSSFPVPSPVISILLEGATCIVGCHNGEVLFYDIGVPGEDPSPTSEEYTKPIYNPTHLLTIQIPGRTRASQVRYNLSMHYRKPFLFTSSDLVSQLTPKRMDRDNKRDLWEYGEREITIKNSSGNTPGVGPDYLCMLQPLCDEGDLLVAWPDLSVYSLGNFNSSLVWTPKSKVLVEKAHSQSVRCMGTVDRFFLTGSFDNVCNPHHALKPKTDCTNIQRGWDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC25</accession>
    <name>A0A2T6ZC25_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1095905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000421">
        <property type="protein sequence ID" value="PUU73045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC25"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC25"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="308" mass="35024" checksum="E1DC3E61F37230E4" modified="2018-07-18" version="1">MAAVPADTSEPDGPLDMDYYLTEGLEHEEHQRYRDVSSFTSAIDLRAKELRSSNADEFPSTYLVFSHVTQQHLGTLQIVRNSHYKSLRFFYLRPLRALIVKMTIGESHESAIRAFEKVFDRKLVALGMGNILKSLGSTTFNGIDDQSRKEANAAFKPYSVRKNKGDWPSMVLECGVSQSPQRLKVDAHWWADNSVGDVKIVLLFIVSEKKRTIRLQYWKVEIVPNLNVTRSRPDPTIPRIAFENTIKIDSQGVTTIPKKGKEIAGGSLNLSCDRLFLRDPVEGVDEENVTFSTEDLKDFYDKTWQGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCF0</accession>
    <name>A0A2T6ZCF0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000408">
        <property type="protein sequence ID" value="PUU73168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCF0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCF0"/>
    <dbReference type="OrthoDB" id="5479462at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="506" mass="55765" checksum="CC1094BBAC6685D2" modified="2018-07-18" version="1">MDSSYQSPAMINTGDTPVNTISPTRGRGHSTQSVLSLSDPLPLLGGTSEVHLNEHHINHNEWQPRAEEYTLLEPPVSSTLPQPPSLSPEETQEVSAPVSWDYEHRSALRRPGFLVPAPPCDSDIQTPSTIYSQSALSSPSAPSSPSPPLSRVAITQPIAPLASQKRSYSEYTSETDIFPSTYGFYKCSDVRQFANPATNIAIHTQLKLLDRLAELSKNPNTTYGYAFHTLLHQALVQNPHVYLTALAAMKTSNHRLISLPVPLITCPSWDSFHLMDSAFPFQKYIESEKEVPGIRLLYPLNASNLSIGTSLSTRETVKAWWTSSGGDLNRATSQVESEGLSAVQLGAGEMIAMPPQLLWSVGDNGPDNPSLHTPPVLSKFTEVRYLSLTPNGQLDFDYWPTGNYEQISRLNCDLLTPPVTGWGTDAQYGWTLAKVAIELQGVWATGDALLGLISWHFPLVQLELHERFDAGDGGWFNSEFGNEIEARVDRKLDSMLETLEKVHNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCI3</accession>
    <name>A0A2T6ZCI3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7881 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1135793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000410">
        <property type="protein sequence ID" value="PUU73124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCI3"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="86" mass="9655" checksum="664712E293E19408" modified="2018-07-18" version="1">MSSPVSTTPKSYTNQQAKIMMLNRASVRNVHIYNANDPSMVPGGLLPTNGATTANFYSMVEISPRPQKGRGWRFETSGLRRYEYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCK3</accession>
    <name>A0A2T6ZCK3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sulphur transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1005491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000399">
        <property type="protein sequence ID" value="PUU73220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCK3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZCK3"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046513">
        <property type="entry name" value="DUF6691"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YEDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30574:SF1">
        <property type="entry name" value="SULPHUR TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20398">
        <property type="entry name" value="DUF6691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU73220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="33660" checksum="CF7E4DA92F452C10" modified="2018-07-18" version="1">MFTPVESSFGAFLLHLSTTHLLLGNGRVLGASGVLGSAFWKPDGHNIPLLVGMGISALGAWYFDTWWKPSNAGAPEIFGGWTWVICGLLVGVGTKYSNGCTSGHMLCGIPLGRLRSVVAAITFSATCLVAATVVGAYTESPCGSTPCYTPTYPTPARVKQLIAITATAMAITRTSLPLLRKLPQRTAEIIASLWSGALFSLGLMIAGMTNPTKPLGFYSMITDGGKRWDPSFLMIPIFALLPNFLIWRRLVGRADAAPRGGWKTPTKKGIDFKLIAGSAVFGIGWGLLGVCPGPGIVGGFLGGWRGASWVFGFVLGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD60</accession>
    <name>A0A2T6ZD60_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1068999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000377">
        <property type="protein sequence ID" value="PUU73430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD60"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="231" mass="25641" checksum="A7D2B9624ECD9E4E" modified="2018-07-18" version="1">MLRLSKALPIFISKPRMTAFHSGTHHGKKDGFPKPTSVEGEALTNLQAWQQYALNQQALSGEQLDKLTKALRDHQAAFLEHHDKKEQQLQQEIAGLNKTLMAEKIRHLNRIEMLNLRGALEWIVQESQEQQKGVPSKKGTPGKQAALAAIAKSEEFTAILEKEAQDRGLKPEKVRGALAPLYSKLSGYAHGVDQPVVVKTRNLGPDERAALCGGGPVESKEHRHTMNTILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDE7</accession>
    <name>A0A2T6ZDE7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SacI homology domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1094909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000370">
        <property type="protein sequence ID" value="PUU73512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDE7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDE7"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="331"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="905"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1071" mass="121553" checksum="0E2D175922BDE2F6" modified="2018-07-18" version="1">MAVTTGSSPTFSNPSSSTNSLSTPPQLDTDDSLSPSSLVGEPCGMSSCGSDMGEEACKGMNCEIPVLGRSEPSIVSVRAFPEDESASVTTQPTITTTPVPVTADEAPAPVTPSHPPSLSFRLEAPEPTYPQLLNNPPASPIANQPHRISDDKDEESSVPKSFDRSDFKHCHKDHKEFLHDDEKDFEGVRRMHKFTLYETATRFYIVGSDLLDSRFRILKIDRTAEIGDLSITEDEVVYTREETAKLLATIEDGNISTGGLKQKCPFWGLLGFIRFTGPYYMLLITKRSIVAMIGGHYVYQIDSTELVPLTAGMAPKKPERNSEEARFVSILGNLDLTRSFYFSYSYDITRTLQHNIIRQREALGKGLAKPGDHDYNDMFAWNHYLLEPAKSHMRNAYDWCMPIVHGYVDQAAISVYGRVIYITVIARRSRYFAGARFLKRGANDLGYVANDVETEQIVSEMLTTSFHAPMKNLYSNPNYTSYVQHRGSIPLFWTQKNDAATPKPPVEMNLVDPFFSAAALHFDDLFQRYGAPVIVLNLVKSRERTPRESILLKEFTQAINYLNQFLPAEKSIRYIAWDMSRASKSRDQDVIETLETIAENVLNTTGFFHNGLKPGNENESGYSLQNGVCRTNCIDCLDRTNAAQFVIGKRALGHQLHALGVISGTSIDYDTDAVNLFTHMYHDHGDTIAVQYAGSHLVNTMETYRKINQWTSHSRDMLESFKRYYNNSFLDGQRQEAYNLFLGNYIFAQGQPMLWDLSTDYYLHHADPRLLKRRRSYVKWWTPKNLVERSMPEIPPLSDELAARPYCHFDDYWLEYYRPKALSSFLKVFTYNLNSTLRYIPVKMTQTGRYDLSPFTVRSNHVDHHHAENAEKKAKVERDSETAEGRLKKITALHGWLPPQNGIAPPQPPPPPPRKSSTISVYPELSRGFSSPTKQHFSLGKDLMQIERRDMDQAIERSLNPVLGEEEAEEYKRYMSHPLNLPLVVTSELPEDADPDFVYFDYVNNASPEAAAGMTAKAEDVALYDEFVEVPENPLSVDETDREKKRYIAYQRWITTGNFKHLRNYVGSIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDG2</accession>
    <name>A0A2T6ZDG2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1111160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000369">
        <property type="protein sequence ID" value="PUU73538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDG2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="215" mass="23270" checksum="2CA5EBE8B0A34944" modified="2018-07-18" version="1">MNSPPASPTPASSSITQKPEHSTLLLTTLESTLTATLTHTSTLENLTQQLRALRETLQSLGGLHLLAQTARNKYLESLRRDAGLTYSRLLTNIGGGGGGGGLDQEFGGGQGGDAVADALLYRDGIRDDEEFFILVYGVEWGKVLEFRHNQELIQAISHRADVFSRGQGFTAEFNITFEQLITWAATATGHGPPAVLLLLSEDNEALSWFTHIMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDX0</accession>
    <name>A0A2T6ZDX0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000355">
        <property type="protein sequence ID" value="PUU73685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDX0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDX0"/>
    <dbReference type="OrthoDB" id="5399929at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="425" mass="46194" checksum="0DD02BDED902244A" modified="2018-07-18" version="1" fragment="single">MDSQIEFAAIETDPAGKNSSISNSQLTERQKEVKERQSETAILFGNLNANSASKRGRLPKDAAKATSSPRSTRLSRSPIKESGRLRFGESPQTRFSPADLPESPLPKHTGSPTTRAPEVEPPVGPVADITIDSPRAQDADGMICIISDAVNEAEMRQGTGSSSVEDDNFVDAPEDRISSGEEVEEVPKNSASIVVEISPIQNSRVCDKGSHPESCFTPENEENSKISEPNTESDNSPSRKSSPGAQIMTEERAASKLPAKRRRARLRPRRRSLVRKASESPRKVLDSIAVAEPDVPQSKPLTTSYQAHNEQTECSPHKSQPNQISSPSKSSSSPRKPPTISTMSPPTTRSSVKKAAIAKPPAPTQSTRKRKLEVVDHYGSNTDENPSFENLATPTPKRRNTASLPVRRTRSSTKESSKYNDNGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDY8</accession>
    <name>A0A2T6ZDY8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1003335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000351">
        <property type="protein sequence ID" value="PUU73708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDY8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDY8"/>
    <dbReference type="OrthoDB" id="5338955at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="780" mass="89278" checksum="A9E2C8C81B77CBD8" modified="2018-07-18" version="1">MNRPRRPKGSHYQPPRPNVSTFFNSILEPFTAIFSPWRVLPPEAPCAPFITVQESFELLNARILAEGSTSTAIREYKRLKAIDPGLRLTGPATIVLLQNLLKLGLHTPTLEVLRMENLVFEDGVKLLKIAMEGLSPEQRRRVAGRLLEAGEDLHHKLFRSMLSEEIKSFDVKQIVVRNDREYDRNIRRAWTGDEMRKLLDEIVSTRARITRGTSQLIASRLVNLNELNLGVSYALEPLINISQSNYIATICNALCDARRYDTGYELIIKALKSEKYGLLSDLDIKRGVRTVDTMSQPHLQLYKLWNAIKSSSSVYPRDLSYHTYAAFLGRATRLRFGPQDSLREGKGETPLLTMSIEIIVRFTDHEKQMAKGLLCSMLEAWIWSWGQTCSHKPNLQTLKGSIPFMAPLFNILPPKTRDPAILMAIERITTNCIKSGREVWPLWIIWPFISTLAQANIWREEESIGLWAAERVLLRKRLAPTYLRYRTDAEIARFVTRHYLPLRLGLTGPKRVTQQTQDAERLMVRLRSLERGAASFPHLSVFALAILAFKDTCIPSTILLLDMIYTLYRLHRYADIPTLLASLKFYNILPSRSDIARLIRLLTKADPPSALRLLQTYPDTQYSVFAQFIVRTASLHPKLAVRAYQLLTPPTLHYFSRFRQKIPGRRLPGRKLLVAMGWKFANSPVLSPRQCLRYTQRCLRAMLVLGLDPGPKMGWSIAIAGVERAIRAGVPVSREWGRVKWVLRIIRRNAGVGRAREVDLMLRSWERKVWNDRMGMGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEJ4</accession>
    <name>A0A2T6ZEJ4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_497318</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000335">
        <property type="protein sequence ID" value="PUU73899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEJ4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEJ4"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="59"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="259"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="365" mass="37845" checksum="464EC71DAB76C9FC" modified="2018-07-18" version="1">MQQPTLAPAPHPLQSPSAQEAANTAEQSWYPPHFLASAITVTTATTLETLRAHLLPHIHSPQQQQQQQVQQQQQNVTSPDSKPTDSASPDLNIDPAISGVGAPGGVSSVPQSPGLTTMAIQGMSPGSQAAMDQHSGAEETQAEGSSAGRGRGGKRELSTSKRAAQNRAAQRAFRQRKEGYIKKLEEQVRDFNQMQESYKQIQAENYQLRDYIINLQSRLIEHQGEEAVPPPPLPLLGSSSSAAGAIALPTTTTTAAATLPQQQQQPPHSPLTDPSAPTANMGTVVELSNNPAANPSANNPAGAKRAHEDDAANAFLQNVAAAGNGFLQQQAAVAAAAIAGAGAGNGGGGGGKRLKNGDESSVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEP5</accession>
    <name>A0A2T6ZEP5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000331">
        <property type="protein sequence ID" value="PUU73949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEP5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEP5"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="379" mass="41430" checksum="FBA15FD4C7B3BF8D" modified="2018-07-18" version="1">MLDAREVCSGAIGCKGGHIKPNSWELFPKLVAIFGRDKARKLTEFRMGILDKMIAIADAEGVTEECQIRKEEAVDVYFDAESWAIAKSCLDIYLEEFPEEIGKWETYEGEEGRQEFDIPHAKGIIAGPAGALGPARLIHPILARLLSTHPTFTLDSRTPVTSIAPPDSTISPYVAHTLLGEIKATHILRATNGYTANLLPGLTGALLPILRTLTAQSPPTKILFHRNRRWKFHWDQGYDYLTSLPDRTVMFGGGIRQALATEIGTVDDSVVDVRTTIHLPGVQPDNGVDKKVQKIWAGIMGFSGDVLPWIGEASPGISKRLQGTGKEDAMCAACGAAEEVVARVLRVEGAVGVIEVMDVTVERVERAKGWERLVGMFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEU1</accession>
    <name>A0A2T6ZEU1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1196528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000327">
        <property type="protein sequence ID" value="PUU74018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEU1"/>
    <dbReference type="OrthoDB" id="10656275at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015469125" evidence="2">
        <location>
            <begin position="16"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="313" mass="35031" checksum="82C63E6039D6742F" modified="2018-07-18" version="1">MFLELLLLRLQSLEAYNSYHQLEAKAKGVILGSTSPAFRLYLTGMTTAKEMWNTLKNHLDKAASINGRLALRRQLLSASPLAGSEQRIDDTSFKDKLLSSLPTSYNNLMEIIHEREAELSVEDVIRKVQQSEIAKEMEVKSTNTSLATGSALITTSRNDFAHRRFVPVRSRNMNCYSPYNNPSSHFNGICFHYKEKGHQASMCPHSLPGSRFNTSHIGYMKNNGNKPTSTCFAYGEVRHRSQDCHYTSLTQDQAVRDRNTLLTWRTSTIHKTGQDTTTSQANLAIQGQSNAINPSASMSSDQSLLHSSHPNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF02</accession>
    <name>A0A2T6ZF02_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_1001814</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000324">
        <property type="protein sequence ID" value="PUU74077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF02"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF02"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU74077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="683" mass="74947" checksum="8CEB3791D43EAB64" modified="2018-07-18" version="1">MLRLSSSASARVIGFSSRSTPSRHQRHSLKLQQTQYQQQRFLADTKVPRPDTSTKRSIKDVKPPVLPGGAHPATPAKPPPAAAAAASPISPTPKITTTPVAPSNTSPTPVPLTSPPPAKTQTSPPIPAPKVPPSATTSAGFSAPPPPPPLVSSPVAPPKQPKKTHRLRNFVVGLTFITGLSFAGGVFYSLKSDNFHDFFTEYIPFGEEAVLYFEEREFRRRFPNALSRVAPPPIDSPKVVIPKASGATWKVFEPTEDKKVTDVGKHGPHISSRGTVEQDKEGGKAISVPVGSGTDDAAEVEAAEKLGKPKAPTGHIALVDMRDVEDPVVRDLANVVNSIITLVNESESPKVFDSVITTAKSELSHLSSQIASIKQGLEKTVKEKDLEFTTAAQGLLKNVDDEITNIEHKWREEFEKEREKMAQSYREKLHTELQRSGEVAEHRLRNELLEQAIAMKRKWIRQIEDRVESERNGRLGKLKELSGSVEELAKLSTAWTDILDANLKTQQMHVALEAVRAAYESPEQPKPFLRELAALKEVADDDEVVRAAIASINPLAYQKGVSTPTQLIDRFRRVSDEVRKASLLPEDAGVAGHAASWALSKVLFRKKGLAQGDDVESILTRTETYLEEGDIDNAAREMNQLSGWARVLAKDWLKEARLFLEVQQAVEVIAAEARLQSLRVHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF33</accession>
    <name>A0A2T6ZF33_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1103623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000322">
        <property type="protein sequence ID" value="PUU74107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF33"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF33"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052138">
        <property type="entry name" value="GATA_ZnFinger_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47255:SF4">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="7">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU74107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="483" mass="53696" checksum="0A0B9BD4AA604A79" modified="2018-07-18" version="1">MMNHPSSSSPAQSYNIPASMRSVHMYAGGMPLVNGVNGQLQNMQISPLAAQQAIMGDPNNNPMLDASVIMSMGMTGEDGMVVDPQLCTGGDRFGPLSVTAPPTSMMTEYGSLGGGSTLTEFTKRRNWSQRILEELQDFLHILSPTGKMVYASPSSKALTGFGPEELLGKFITEFIHPDDSALFIREFNSSIATGQPLRLFYRFQKNDGTWAIFETNGHPHIGEAPQFSPSSIQSVCKGFFMMSRPYPTRNAALLDSFLEHKIENERLLKRISELRKEEFEDHQQQQRQRQQHHATVSRTDSGTAGSSMASNVGNDNPMATTPNSSDPMPPPAKPTHIRDKMARFEGATHMDTIEMLTGLRYREGERSKGISTGDTSPALIRGDAGVPIPIDKESRHTSEKKKKQKIADEYVCTDCGTLDSPEWRKGPQGPKSLCNACGLRWAKFERKEAKCWLCIIASRIHRLIGGLKDLHWLLFYYVYLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFP1</accession>
    <name>A0A2T6ZFP1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFP1"/>
    <dbReference type="OrthoDB" id="2149705at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19899" checksum="2D0BDA2586FD0956" modified="2018-07-18" version="1">MPAIRTGEKPKENTRQLTLTGELASVTPSSSSSKSPSKSSTDRIYTDAILSIKPEFVELITEQKKNHEYRKYELRDTVARIWVYTTAPTSAISHVIVTSRPKTPGQVCDPNGVGNDDFDNGMKKSKFGYPILSLYKLKTPLEREAMKAYGVTPPQSYMYAPKKMVDENPLEDMEKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFS8</accession>
    <name>A0A2T6ZFS8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1196291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000305">
        <property type="protein sequence ID" value="PUU74345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFS8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFS8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="24024" checksum="7AB357BF495409B9" modified="2018-07-18" version="1">MAHIKKEQSVDLTYPQRELQIGVQAPHNTITQSVRAGKAPALNSEDSIMRVLKDTAEGVAKVVQGQATILRKLEALQDRQDAMLQELPIIQQEQAPLIQTVGRLEEGMRRLEHRLDAIHPEVRGIRPDSPHHEQNRIARLINRRAKRDNTVLEPFYGFNGQLIPDFPRTLGDTKRLNSLDLTILLLYLGLPASGSFAVRKARFLNYVGLVYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGG5</accession>
    <name>A0A2T6ZGG5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1092494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000291">
        <property type="protein sequence ID" value="PUU74575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGG5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="106" mass="11948" checksum="7100822FDF533AA1" modified="2018-07-18" version="1">MEFRLEAPTGSGNTTGLWTDDLVSGSGLLGRFFFFQAQLGAGLVGWLVDVRIILYMRCYDAGTGEGCLENERLVEVRGRDVRRRGSIFFYPPFFLFSFLLIYFGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH23</accession>
    <name>A0A2T6ZH23_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_406063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000274">
        <property type="protein sequence ID" value="PUU74787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH23"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="19526" checksum="BA04B293BDBE9DA2" modified="2018-07-18" version="1">MVHDFQDKMFLPYQLMHTTAFFLFLFLFFPTVCCLPIPFVALLPSSHLSFHFHPPLNQALPSLVTRRERREGNYVNFPAPVERNISSVRPREQGLGYLNVVSLVCMVVVVKLPMFCFFFLLRWLLFSFFFSFSFSFSLPLSFLFLSFFPFLSATKVAIHFSTTLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHB2</accession>
    <name>A0A2T6ZHB2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_392897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000264">
        <property type="protein sequence ID" value="PUU74875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHB2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHB2"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="742"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="773"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="883" mass="95505" checksum="85265B7D10F324C7" modified="2018-07-18" version="1">MQFAVAYDPHHRHQYQSHETKINPDQPTTYYYCSSRTLTAPEAGPSNTSRKVAEPLSASEIQNLCQQYQRICATRRTRRSPKGNHYEIPVTKESNQVTLRSQPRCKGSGHSDHLSECDLSEHVLGFPGVRKEQQINETSQEPPRESSSSASFFTASSTQIDRLVYKPTKQTRKPSSPLHTEGSRQAFPQKNASTDPTSKITLNPYPYLGSFDSTRSPPDESWSRGSSPRLEQAHPHIYPDERRSSVVSFDSTVAPSSPQPTSPKSKKRERRPLATQADTVLLKFLAPDQPLVAIRAGESPLSWSTESEGNNEVDMESGAQDGDGGGGSSSGGKENSQNGSREQSTDQPNGGTGEANGEGSANNGESSGAYGNGGGDDEKKNKDEDGDEDKEKAQSTGNDNMDIDTVTADALKSHDIPKPEKGAPRPEYEGGPVEVETSSSETAVSLMALAAGDDRQPFTSATSLPGIPSKAGGTAWVPNARAKSPNPSQSRGLPPSPSPSTQLFQNNKLPLLNSPTQLPSMVSSMNSQPASSPNSLPPGNDGRHTTLPPVSSIQVLAEMAEKALPTQGSTWTNSPPRSPGLPAPPGQSPHGGFGPDSNSRPPVHHMTVQQKQYYLNQDPPSPYYSSPHQHYQPPYPPMKEGASSNTNGSTVSYQSSIIHPRELPGIMQNHSPPSSGFFSPPALSGRRDSTTMEYYPAGNTPPSGPSTGDTMPSSGTEDTITSPRSRSTVAPGAQGPLASGGFKCEFTGCKAPPFQTQYLLNSHANVHSSARPHYCPVKGCSRGEGGKGFKRKNEMIRHGLVHDSPGYVCPFCPDREHKYPRPDNLQRYFETLSVKVMRTDFSCFNSHVRVHHMDKDKDDPQLRDVLAQRPEGGNRGRRRRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHJ2</accession>
    <name>A0A2T6ZHJ2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1103202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000258">
        <property type="protein sequence ID" value="PUU74968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHJ2"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="401"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="716"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="832" mass="90918" checksum="101C4E5592A0CCC9" modified="2018-07-18" version="1">MASHGTVHPDTAIKTKVTFNKNTRCFKLVLRDLGPNVLLPKLRTLLAIPEDTQVIFERYSDSAGGYVVLDTAEPAAFKQLYRAARAKLKLRIQVTIVPGEVPAPADPSSSTDTLTDQRNVPSTEAGPSTQPSPSNVSYFSLPPAYASRLSLVPVEAPFEELAAADTTTKFAPPPDLGQTVADAVSTYLSGDEYLQKLRETVREEVEKEVEKLEKSPEKLERAPSEAPVPAPFAAPLTDISEFENFEAKTATSPFTYAIYCNSCENSIKDVHYHCGCCDRGDYDLCKSCVARGIHCKDSTHWLIKRVLSPSGVIVSSTTESVSQKDGSVKTPPRRTCNCCVVDLPSKEFVTCKVCEDYDVCISCHTSLKHGHNPSHEFVPATPETMLQPYAISLLAPGRAHRHYAVCDGCDKQIYGVRNKCLSCPDWDYCATCFSTASESHPGHRFVSIYEPLSLGFIKTDSVKHFGVYCDGPMCADKANRSWIVGDSRPINPHNASHPLIKLKTPVRNVHVTTMENQDSENVLGDVPVPAPTTNAATQVQTVAEVKPLEEPEPPFENVEEYFEKTVSAAEEEKVEPEAEPKIRAELEPEPVVPGPEPLQATFVRDTIPDGCKMIAGEEFTQTWILNNSGTSTWPAGVSVQFVCGDEMFSNNEGSSINATVSSTETPPGHPAAFSVNLKAPFITSRRLITYWRLVGPDGSRFGDKLWCDIQSIEKPKEDKMEQSVLESKDEFEDVSEHANDGSQASSQMIFPKLPVESPVASTENLVAGVSLKGENMPVSAPMSTTSTGMGDDESEVDVGSLGDEVESFLTDDEYDVLDASDEEAFEECEKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHX9</accession>
    <name>A0A2T6ZHX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1091142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000251">
        <property type="protein sequence ID" value="PUU75093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHX9"/>
    <dbReference type="OrthoDB" id="3799394at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015532615" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9313" checksum="FFBFE331DE9C7315" modified="2018-07-18" version="1">MKFLPYRAITAFICLLTSTAAAETTLASPPRLVPYPIACGGVAVCTGGSFDACVGDVICTQSFPGSCLCQNNAKMGCASACGAAKPELQSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI90</accession>
    <name>A0A2T6ZI90_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1110228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI90"/>
    <dbReference type="STRING" id="42251.A0A2T6ZI90"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU75192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="543" mass="59772" checksum="20E4C4F9D04B1FE1" modified="2018-07-18" version="1">MSSLLRYIRLPYKAGAYGTARWSNKDLDPVPVELRTWGGLDYWAYWCSDMLAPPLAATVSTVMSLGFTARETIPIVFFGFMICSVVVTLTGKMGATYHVAYPVIVRSTFGMIGSYPAIVIRAFVAMMWTAILCVQAGAFLQNCIEAIWPSFKKFPNHLPENAGIDSAGLLCFFLYWMIQTVLSLMPIQKLRLLFLAKGIIVPPTFLALFLWAVIKTHGGGPLVTGKYHLTTPMNTAYSALTGLNVIIGLFSSMAVNMPDFGRFSKNNLAGGHQYFALPIIGTLGALTPIFVTSAHSEIWGTFEWYMPAVIAKFDSRAAKFFTGASFILATIGNQIAAGSFPFSNDVSGIAPQYINIFRGTVFMSIFCVVSTPWNIIKNAAGLLAFLSGYSCMMGPLAGTIVCDYYIIRKRKLDIRELYNDHGIYWYTYGVNWRAWASFLLGFLPTLPGFAHSIEKTLNVGGAWKLYTFAWLFGFSVAVVSYYIICTYISPPTESLVEFAVLPPGKVDTSLGTTLEAEVASDHKAEDIAIGEKEIGRESRDSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ98</accession>
    <name>A0A2T6ZJ98_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1131185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ98"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ98"/>
    <dbReference type="OrthoDB" id="1737613at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000026">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="479" mass="53902" checksum="6606275B77EA3DB9" modified="2018-07-18" version="1">MPLRAKILNPGFSSQQKMSASSLVIKEQDDDAPNDVLFSSTYGIRTIELNRPKELNALNGSMARKIIPRLREWEKSQMANIIILKGVGRALCAGGDVVKLAEFIKSEGPSGVEKAVEYFELEYRLDHLIATYPKPYVAFMDGVTMGGGVGLSVHAPFRIATENTLFAMPETTIGFFPDVGGSFFLPRLDGEIGTYLALTSEKLSGVQAFYSGLATHYIHSTSLPDLEARLAELVFGDYQPLEERWKIVDSTIEEFVTGLPEDTPIQLSGEIREAIDRCFKFNTIEQILEALTQEDSDWSRKALETIETRSPTSVRVTLRQLRAGKEWTISGTFQRELHMAVKFLEGKDFVEGVDALLIRKTKDPKWDPPTLESSNESVTDPYFTMEGDRPRLQLLRDESDASFVDYRQYPHARIGLPSEAEVRQLIRERKMLPDNIIPYLVEDRNGKIGLVEKVRDIIDRKVSTGVDRAIWKEESVESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJK8</accession>
    <name>A0A2T6ZJK8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_993904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000223">
        <property type="protein sequence ID" value="PUU75594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJK8"/>
    <dbReference type="OrthoDB" id="5355526at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="9172" checksum="5FB9E54E975F817E" modified="2018-07-18" version="1">MCMRVVERYAVCKCVYYTHGIDQCSAYGRRGHAVQDKTVLVGHTCPNHSNANWATGPSPDFGGFPGSGNAGGLGEFSRYHAHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJR7</accession>
    <name>A0A2T6ZJR7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1102821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000219">
        <property type="protein sequence ID" value="PUU75654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJR7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJR7"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="170"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU75654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="63800" checksum="5D4F7DF1CA112608" modified="2018-07-18" version="1">MDMTRHLLAALNLPPIRDVPPFPLGSDTQPRDRPLPLEPSTSQDAYSSSQYQQGRREPNQQQSQPQAQQPPQQQQQQQQQQQQPPHLQQLHSRESPNDHSLNPTKSTPAPKEKEKSKDKAKSNNDRQDQVTTPSGRSYPPLLPSAMPPSEVRTPKSGAGNKNSTPGEKSSNRRVRRKWTEEETNDLIKGCHTHGVGNWKKVLEDPRFHFNGRSSVDLKDRFRTCFPKEYRKPNDLESEEDTERIPGPAPESDAIAVAPLPPKTPKIEGEKSRKKTTKTELHHVEVLEKLGVPNSFPKVQRRERREFTVEEDARLLHGFNIHGAAWSKIQSDPDLQLSHRRGTDLRDRFRNAFPDRYESAGFKARPRQRPKPPRSSSSVKEKVTDAIEANGELEDRRGVGLEGSSKSDNASLLMQSLLAGHLSPGWGAGDTPVTSSDQSPAPGTLALDPALNEGFSGTLEQIAEEFLAVAQGNGKEPTQGSGQEASHDMVRWEDMANNPIFDIDPAMTGNSTAPHPQAEIGSKESASLSGINIGSNVSSSSTTENTSHDKGNAKRLGEEANPETIHKKRRTTDELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJW6</accession>
    <name>A0A2T6ZJW6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_993162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000215">
        <property type="protein sequence ID" value="PUU75788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJW6"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468:SF1">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40468">
        <property type="entry name" value="YALI0A15257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU75788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35023" checksum="AA062A59DC8EFBAB" modified="2018-07-18" version="1">MSSLPASKPWTEKQTKEVIRKVIRRAEVSRIARLLQHRLALANFKTKNGWENLTLDTIEPKVEEDLRRKRQRGSQEKSPSPGTSFFSEGDLEWLRKNKTNVQQKRRGSQSSGIGPLPNFRNSRKRVRTSSSTEFQQPPSKRRQSWRDQNRTVQSSPGYRYGTGEGKDGLEHAFHSSPPRTPPRRIAKPGSANKSAGDRGADLLIYLATSPSPAGVMPKAKFTPTTPPSNSSALPSSVMNTPGAPQTPQTGFNFADFVNITPSPAQGAWGSVGAGRGTPIANARKRLNFDQLHPPTGSPSVPASNSRHTAGLGMELGGELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKN1</accession>
    <name>A0A2T6ZKN1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanyl-tRNA synthetase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1102579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000205">
        <property type="protein sequence ID" value="PUU76050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKN1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKN1"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phenylalanyl-tRNA synthetase" evidence="6">
        <location>
            <begin position="80"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Phenylalanyl-tRNA synthetase" evidence="6">
        <location>
            <begin position="260"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="410" mass="46544" checksum="E6D86D7C59064680" modified="2018-07-18" version="1">MPLPFPSRDLLAASGAFGGFSGVIRTRGITQSCSRWCKYPTTEEPQSPPTTQLEGRHYPIDEWTNLPSHISCALPRKLHLQPSHPLSIIKRLIESRFPSPIYEYHNDLFPIVSVHQNFDSLGFPIDHPGTSRTDTYYVNKDTILCTHTSAHQADTRDAIDWRDYQLFHQMEGASLWSRRECKAREATAAVIKEDIEGIPKREINFEDPNPNSMRRGIRCRRELWRALEALPEHVVEEVFGRRGIATAPGDAGAEGASEEPLRVRWAGAYFLFTSPSWELQVYWQGNWLELLGCGIIQQSLPKNADIPNKVGWAFGVGPDSSSAPRGQIPFHENDMMELEMIDESTHPKTGGNSLCFRNNHRSLERSLHNDEVNSLQQMVKKILVEEFGLKYGRGVGSSYTPFFLFSLLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL69</accession>
    <name>A0A2T6ZL69_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1130111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000198">
        <property type="protein sequence ID" value="PUU76164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL69"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL69"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="48570" checksum="88550AD525DD3FF8" modified="2018-07-18" version="1">MTQSELAEWYKLETEFFQDHVRHTRYVEKEKNRYRRGNSTPGVSASSISKSGEPQAAINTPEGDLTKHIGSPLEGSKSYDINIFIVSMSPVRVKLGDFGISKRIQPQDTTTFHTQASTQIYGAPEVLGSGSNSEISCHGNSPQGTKNLVTTGNCPFPKINQRVITSNRQCWNFIPKAHAPNTAWRLHYRGRCTGQCVVGGFKSDNEDRRDQDETAQNRDEKHSGKKRRSRRNPTTQDNSKHAPGDVALKANPGLQSGSEPTASKDAGEKTDPRYSTTMSLKPPTSSPPMPNPHHGNSPQLAPGTNGRIGHTLKNEASAPILDAPKKRIAHPQVHPAGRAGSNQSPRAVWEDQGIKSCKTLRLMPVGGGAVENTSNGSNTHQNSNTGPNPNRNPNTGSNLSQNNISSNSNENPATGSNPNRNPNVNPNAVPNHNPNSNTGPNPNQNPIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLB8</accession>
    <name>A0A2T6ZLB8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1102457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000193">
        <property type="protein sequence ID" value="PUU76287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLB8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLB8"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="511"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="597" mass="66491" checksum="E97B2A93AD3CBBA7" modified="2018-07-18" version="1">MVGAVLCGIPLVYVGLRSLRRKRNQEDEEEEVRSLKGAPDDGHSVHSSYESLSNANSSVSDSSLLRKHSENISVTTKHYTYPAVRVFYRPHPKASVLPPKLPLLVFLHGLGGQMSQFQYLLEFFVHISHTLAIDLPGCGPSSEFSPKDWDAYTTSRLVEIVAEIVNQKLEDGQQVVLIGHSMGCSLAVTLIAKGGLLVDKCTGLIAICPKATVSEKEIKTLKTALALPEFVFNLFRIYDRRGGIVSNSVNRFVGSNATEKARKLQLRFNKESRTPVWRRMASGIRLPTEEEWTSVKCPTYLLAASEDKVCTTKEVDLIHSWFDPAKRSGSVSTAASVGGSADSTPSPSLSPSPARTRFVVKKCIIPNAGHGVMYETPQVVSGLIGEFLSECVAEVLSLGWQLLYLKEDKWLLKNLEKWTRIQSVSPRIGGYINSSGGPYVKSPFRAMKTLRQNDPNGHNPIEFGGQWPDVKDVIDISHEQPPYDPEAFADDIRYHKFPTVSKIPPTQDEVASFIKLVDSIREERGYDDNITIACHCHYGFNRTGFFVCCYLIQRLGFSVEQAIKAFKDARPPGIRHPHFINELFERHCLGLVRAPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLG8</accession>
    <name>A0A2T6ZLG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic ring-opening dioxygenase LigB subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1115929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLG8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLG8"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="323" mass="35532" checksum="5F1C6BD5D4835024" modified="2018-07-18" version="1">MPSESWLYEKTTQPNLAQRILKRLSQVTSSCATRVAMATSTSTATAATGRAPVYFVSHGGPNIMYDVEHPAFHQLQKIGKEITTKVKPKAIVVFSAHWQAAAGSKVEVNTAESTDLIYDYHGFPDHYYKHKYPNVGSKELAEKVLGLLKEAGIESEGVRRGPDHGVFTPFTCMFDPEDNPLGVPLVQVSLFSQEDPNMHYALGKAVSKLRDEGVVIIGSGMAVHNLRDLRSAMMSGGPLDYVAPFDSALKEAVTNVTLGEERKTKLAELLHRNDARRAHPTFEHLLPVHIASGAAGDDKAIQLWTLPEMSMSWAQYRFGEVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLM5</accession>
    <name>A0A2T6ZLM5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_990727</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLM5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLM5"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="411" mass="43828" checksum="295EF03AB9D73FD7" modified="2018-07-18" version="1">MTIATLPIEDAPRFQKDTRGFATRAVQAGAPHDPVTGAVIAPISLSTTFAQTSVGNPVGLYEYVRSSNPNRDHFEHAVAALENASYALAFSSGSATTATILQSLATGSHVISISDVYGGTHRYFTKVAAAHGIRVTFTGAIEVDARAMIEENTKLIWIETPSNPTLSLVDIQSVADVAHEHGIMVVVDNTFLSPYVQNPLDHGADIVIHSVTKYINGHSDVLMGVAAYNSSELNDTLTFLQNAIGAVPSPFDCWLAHRGLKTLHLRAKAANENAMAIAQFLESSPHVISVNYPGLSSHPQRKVAIKQHRKAMGGGMISFRIRGGFQAARRFCEETKLFTLAESLGGVESLCEVPASMTHAGIPIAAREESGVFDDLIRLSVGIEDVDDLVDDVAGAISRVADSLVSGEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMF0</accession>
    <name>A0A2T6ZMF0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_239348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000180">
        <property type="protein sequence ID" value="PUU76665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMF0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="254" mass="28461" checksum="2F819441EC2E27D1" modified="2018-07-18" version="1">MLNLHFPLPFSEDYILGMFSEPFLSVAPNSHVVSTRGPVSHPIYLPVCLSACLRLSQAGPQQRLIGFPAPSYRSAAQVPYSILPFVHLLASLWSRISVDYSLSTRVPALLHHPYESSTLSAYLPHTHTYAYRSYPTSCQHPLSLPPPPPLKKHLFPPLSLPLLPPPPASLVPSREHTKLSLPSFAVLRTAHEIPSFPSLACSSRRIVRIFPIAYFPIIFFFSFLSLHTHLIITVHTYIHTLLYSSTLYSCACWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN54</accession>
    <name>A0A2T6ZN54_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1066276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN54"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015580885" evidence="2">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="108" mass="12000" checksum="298EC4DBBA66287C" modified="2018-07-18" version="1">MTYFLPFLFFLAFVLSLASGGWKGFYKWVAHGILDRSQFPREYGKQVNVKQESATFYDSRPAQLMFKRSGIQAGTVTQEGYNTSATSAIKASHGASRGDSAFGTQLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN70</accession>
    <name>A0A2T6ZN70_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_988759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN70"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="405" mass="46555" checksum="A339A4F6D9EAFBA2" modified="2018-07-18" version="1">MEDQKKEIIIAVMGVTGTGKSYFIREVTGISDIEVSSGLHSCTTEVQPYSFPYAGAKITLVDTPGFNDTTKSDTQVLLDISTWMSSNYRKGKLLSGIIYLHRITDVRMDGSSVKYVKMFRKLCGPNALQNVLLTTTQWSNVNQAQGESRERELRDGMFWGGLITEGASVTRFMGTRESGLELIDKLIGYQPKPLDIQDQIVGRGMEMTETNAGKFMNEELVSLQEEYQRDLEDLKQEHQKAKKKKDNLRKKRLKKERAQFQKKLEEAEAQRKYLESLRVDMMKKLEEAEAKKQEERERRDRAVIAVASEAIGGDVHFQSMFTSYSTRGRLIYDINDVWEFAKEPFDVEILYQSGILSPIALILKTFFDPGMSDDYYIIYNQGYYQCKPSRSVERFSENFVIFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN96</accession>
    <name>A0A2T6ZN96_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_205183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN96"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN96"/>
    <dbReference type="OrthoDB" id="2426521at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="171"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU76955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="36094" checksum="029F416564AC926C" modified="2018-07-18" version="1">MKSMWTRTSDIGMLLDLVGSPRGIHFAGDTAQCISKDALFRFANARTLFYERFSLQTSSSGELKPELLPLSHNYRSHKHILSVASLVMYLLYRGFPGLVDELPPEVGDRPGPKPTLYVGSNIIDVLRFGEKLETPQEPDSQSGRFNEYGEARVILVRDEETCDKLQAALGRSSLVLTILESKGMEFDDVFLYDFLSTSPYSHKLSVLEELFKRGHHTGLGSEHNASTYQRSHEDWVGENIVLCSELKHLYVGVTRARSRLWILESNTSILDPVQRLFNQTATLLLPRQYPTPILEILEEQHIGVCPKHGLDFRLDYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNI3</accession>
    <name>A0A2T6ZNI3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_988314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNI3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNI3"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="348" mass="37704" checksum="68B809C00F35B5D8" modified="2018-07-18" version="1">MTATKTPIWLDCDPGHDDAFAMILAAEHPNLELIGISTVHGNSSMDNVTANALSLLTAIGKTDVPVYAGSRKPFMRPAVHAPDIHGDSGIDGTTLLPESKVAMKSGNTILAMYEAIMKTPFQTCAVVATGTLTNVALLFAVFPDVVAHIRCVSIMGGAFGGRDDARGNITKWAEFNIYCDPESAQSVFSNPELSGRITLVPLDLTHTVLATSDILATLMTTSHPTTKLRKMLHDLLTFFSKTYADVFNITAGPPLHDPLAVAAVIPGDEIEWDMEEVQVEVTCHGEQIGQTTKTPRDQAHEKVRGEELGKGGVKPVTWIKVPRSVAVDSFWKVMMSCVEKTDGRYDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNM3</accession>
    <name>A0A2T6ZNM3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1066124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000164">
        <property type="protein sequence ID" value="PUU77099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNM3"/>
    <dbReference type="OrthoDB" id="5355583at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="21454" checksum="D4C986D469DBED68" modified="2018-07-18" version="1">MPEDNANHTKRKMEYESSYSEMTLVAAEERLGLDLQEFVSRATSVNQMLEEANYKFYSHREDVIERTKQKVGCNIAEYLHFEGYPTEAGPDFKRANINDLILYIIGPIMWDFGIELDEGNALLRREKEIISPDSKTGGYGEFVVVEKPGPGACESLILIIESKPSLREAIKHCLLAMKDMWSNNGEGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNS7</accession>
    <name>A0A2T6ZNS7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_987801</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000161">
        <property type="protein sequence ID" value="PUU77148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZNS7"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000868">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="420"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="623"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="860"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1383" mass="152315" checksum="67AE124AD6214358" modified="2018-07-18" version="1">MPPKKKSSRSSVADAPEASPPSPAASTVKKSKAKPGTNKANGTTVGSKGKTPVVTASEAGSSASASKGSNESRTLTVQQLIGGLSWTGKLPQTLFYEHCVKAGWNNPDYYIVYATKGFVSSVTVTYSNPKTNLTESMRYTPPFEMPDGTPINLQMASALEARHFAATYALHRVSSMKNIHMMLPPTHKTYWATFDEIKRMEFAKNHAWMYVADPFLDKREWLAAEAAKAKALAEAKKEKPAEAVDEKLKGWYRVPVVDMGTSQRREVEGLVRKYHVWNPVGVSMTRNLMSKVISELVGLDFKRAHVEEACGWVKDKEEALEWLLIHVPEDDLPARFLPGNYATGVTFSSGDLPMEYAAKRLSATGYSLDLCREVLALNSGDEERAAEALMHILVYGYQKTPKGSKEESLISFSDTDLWTEEIGTLEAIWGPERYTRITPTHFKVLLSIPPVHGLRLPKKIFLEIRKPTSTTWELEYPQTIPTLTLSTEGDGDSRLSAQVKLSIIKQTAKRASTLLGEQMIFTVVDWLESNITRIVESPGRLCDVTSGVTGSNEDDVPLPNKAKAKAFRHRNPRNSKPIDWTPGKEASMRLLAAKKAKYSSPDMQNMLQARMRLPAWDMKEDIVGAVNDCQVTIISGETGSGKSTQAVQFILDDMIDQHLGHITNIICTQPRRISALGLADRVSDERCSRVGQEVGYAIRGESKQNPATTKITFVTTGVLLRRLQMGDSLDEVTHIFVDEVHERSLDTDFLLILLKRKLAIRKDLRVVLMSATLDAKIFSDYFGGEQKVRRVEIRGRTFPVEDYYLDQVIVKTGFNGGGRLMPVKTADHEDVQGADPRVASIIASLGDRINYNLIAATVGTIDEMLGSSDGGILIFLPGTMEIQRCIDAIKTLPNGVERFHALPLHASLTPNDQRKVFPPPPYGKRKVIAATNVAETSITIEDIVAVVDTGRVKETSYDPSSGIVKLLETWASRAACKQRRGRAGRVRAGSCWKLYTRNAENNKMAERPEPELKRVPLEQTCLAVKAMEDDVCGFLAGALTPPDTMAVEGAMKLLEHMGAIADDDLTALGRHLVLIPADLRCSKLMVYGAIFGCLDVAVTIASILTTRSPFTNTPATRDASKLARTSFAHGQGDLLADYHAHQEWLRLRQTTSVRDVKRWCEENHLSHHTLLDISSNRAQYISSLKETGFLPLSSSSSSSSDFVRLNQNHENAVLHRALIAAAFNPQIARIALPEQRFAGSASGALAVDPEARTIKYFTHSSGRAFVHPSSTLFNATGFTGDARFLSYFSKVESNKVYLRDVTPTNAYSLLLFGGALEVDTMGRGITVDGWLKLRGWGRIGILVARLRAMLDQVLQDKIDDPGLELAGNEVVACVARLVGSNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP50</accession>
    <name>A0A2T6ZP50_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_987459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP50"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP50"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="429" mass="49105" checksum="D7DD310DEB3D5D91" modified="2018-07-18" version="1">MPVVISASTVSQIRAIVITCITTFLVLYTFSDFLHLTPKPGPANVEYPPPTDTPAPSQPVEQAGSKPEDGVEHEIEEVPISEDVILHGVSVFMPDNFVKHLVLPRMSTEDTTWLTYLSEDLNIIAKPYLIDPDKSKIAPGTLTVPVNKGREAQAYLTYIIEHYDNLPDIAIFTHAHSTAWHNNDLQLSSTPVMLLELNYRRIMEHGYMNLRCHWNPGCPGWIKPKTTEFDDQKKEEFFMHESFKELFPQEAARDGVPDMIGTPCCAQFAVTRSRIAQHPKERYISWRKWITDTPLSDEISGRVMEYVWHFIFASPSLERNADKAVYCPAEHVCYCDGYGYCFGDDTRFKRSAEKRDQARDLAERLKAAEEGVGREEGEDESWRQEGIKQWKRELKNMERDCEAEVQRARRRGSDPKMRWGEVGGLEFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQD1</accession>
    <name>A0A2T6ZQD1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1128093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000147">
        <property type="protein sequence ID" value="PUU77644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQD1"/>
    <dbReference type="OrthoDB" id="5420067at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="190" mass="21201" checksum="8AC5D01687513FFA" modified="2018-07-18" version="1">MSNQYSQNNDIPPIVDQQQPQTAPALAPPQEHSQYLKDLHTQAIILRHELSERLTFLGDYIDHALCLIDLHFNQADSNPELGEKAISPAQTLLHNVLDLVHSAEILAGLPLQRGFEDWQKLDSLALTIGEFVGRTGWMYLGRDFCEIRAWVSEAGKVLEVGKRAIVWLEETIRKVEAQAGSGVVVVRGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQX3</accession>
    <name>A0A2T6ZQX3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_130844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000137">
        <property type="protein sequence ID" value="PUU77882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQX3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="20431" checksum="E5AB790473B10805" modified="2018-07-18" version="1">MSISGVINSNRSRDEHQPVTNRDRQEVFHFVTLLSRTRFFCLQNSPVHHPLILVKTPETALEYFTVKYLLHGTRQRTGLRSLFYSVTDARGLARRISVAELPGNRYASQWGRYDRRLCVLEYCDSSARNVQSASTVLGSVSRKVIGTLAEIPDGHWRHLSRQKAILKQGIFCINAMNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQZ1</accession>
    <name>A0A2T6ZQZ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_985409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQZ1"/>
    <dbReference type="OrthoDB" id="5421902at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="543" mass="61550" checksum="725E3457754C899D" modified="2018-07-18" version="1">MDTLPPEILHNILKPENHGATSTPFGSATKESYLRLRLVCRTFSDIIAPHAFASLCITDNECTLDRLSSISRRADLAPLLKSYLFHFGEPRIIAPSTMKDYLKVISLPKELYAEAMSAHTETCRQQISYLTRILNFQISGDIEKVHVQLLSESFPNLQAVGITVHPAQTLSDILPNLNITSSHSGSSNWGPLVFRAFLNGLALRAESTAGLKPITSISIQGLIADCLFLSGDFLDKISVGMRAIREANFSMTMAQSLHDGTTPSWLYPVGRLLRASGDLRHLALSTIAYPRLNSLVHFTPIISGPTKNPTVHHWKHLTKLFLQHAFIPRELFKTFLTIHKKTLSQIFLHKCDIIDHNRVSMLMHANVFTNQDPQESHPAPWIDIFRHLRSTNKPVLVTLSLKYLSEGKIAHEHHLRQSQVREWQNWIMQSPGDNIPEPRVDVDPEQSPNGGDPELDDYEDTHWCQECSQLSYDSDGDDDGIFGIGYPQFGWPGEFDIDDEVDLDEDEEELDEDDDYDEEVEYVLHHDHFHHHHHHGNPDLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRF8</accession>
    <name>A0A2T6ZRF8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GNAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1115156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000130">
        <property type="protein sequence ID" value="PUU78072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRF8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRF8"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="154" mass="17140" checksum="1D981172796587BC" modified="2018-07-18" version="1">MKLNAKTALLSPKILLVPYEPHHVPTYHSWMEDEDLRTATASDRLTLLEEHAMQKSWREDGDKLTFIACLPPSSSSSIAKAVRAGKDDASECMLGDVNLFLYPSPEHNEAEGKVVAEVEVMIARREFHGMGLGREIVRLFLWYLFWGGGVGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRT1</accession>
    <name>A0A2T6ZRT1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_101746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRT1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="18409" checksum="57465E0964BD83B3" modified="2018-07-18" version="1">MSRNWIGLTSFDRFALGSRACSLFLSFFPFSFFSLSVPFFCRIREPPTISLSPPHRHLSSPPFSPPYTITRNRDCFFREVFFSSFDIHLPYPRKEGNFTAVTIYHSMHFSFSSLQTLKARVWKKEKKNTLSLENDAWFEMMQWCGGSNGGGDDEDTSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRY0</accession>
    <name>A0A2T6ZRY0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRY0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRY0"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="19549" checksum="9634079AA0FBB050" modified="2018-07-18" version="1">MYKHVGAATFYSSPSTVPRSPGKQADATIKPRTRGPGAFPSLVIEVGCSESLNQLHCDANWWLIGSHGATLMVILIEISEDPCSLKIECWTMVANPNARLRNSLAEVPNRSQYFDIDASGTVTGDPKLKTQDLIIPYMCIFDEIHDGMGLIVLLESELSRLALSIFEECRQRSPVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS57</accession>
    <name>A0A2T6ZS57_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_983876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS57"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS57"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="507" mass="59172" checksum="858AAEF372C165D4" modified="2018-07-18" version="1">MDSPLLSSLLRSFFRRRACARPINGSIRRNYSLLPKFPLPKITADTSGETWQPRTAFLQKDRTGEFEKYPMVDARGLARRKERPKRVKMLVRDFIDGRVLSLLKHRTREPEIGEFPYSLYNPNYGFFSKFAVIFSTEKPFAFNLIRDENEFQRILGERYTCFEDKLDEVEMNPVRQLWHTPTELFKPYYGEAIARYLVENYKLTLFPYSDLIIYEMGAGNGTMMSNVLDYIRDTEPDVYQRTKYRVIEISESLAKVQREKAAAGGHSEKIVIVNKSIFDWDTYVSDPCFFLALEVLDNFAHDVIRYDPQTEQPLQGIVLIDAAGDFTEFYTPKLDPTAERYLRIRQKIARPGYNHPLKRPKLIRRLRDQLIPFSENLTIPEYIPTKMLGFFDILREHFPAHRLVVSDFHALPDAVKGINAPVVQTRYNRTSIPVTTPFVQQGLFDILFPTDFGVMNDLYKAMTGKLTRVMRQEDFLRSWAYLEETETINGDNPMLNWYKNASILSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZST9</accession>
    <name>A0A2T6ZST9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_983014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZST9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZST9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="151"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="462"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU78537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="697" mass="75889" checksum="3FB093B481E73021" modified="2018-07-18" version="1">MVIEACKQANAVEFIDRFPKKYDTEVGIHGIKLSGGQKQRIAIARSIIADPKILILDEATSSVDPKNERMVQSALDKVSKGRTTILIAHRLSTVQNADNIVVLDSGNVVESGTHHELLARPQGAYKKLIDAQSLLLGEDPELGTSINSVPGLCIPAGSVFFALIMGTFTFLGDLDAFVRQGYHWSTAYLILAVVALACRFLMTWMFRVLSYKAGNCYRREYFHNIVGQRISFFDKEGNTAGALTSNTSYDPLAIQDLLGMTIGFAIVSVVTLVGSCVLSLVLGWKLAIVCICSVVPLLVIAGYARVKIEMGFVKDTMNIFGDSAAFAAEAVGAYRTVSSLVMEEDIRSRYADMLNGHVKRILKRTLYSSILYSASESLTILATALCFWYGGELMAKGEYGMFQFFIVYMTVIQGSEASGTFFGLTPNVATAIKSIKRMFKLREGHPNPGDEMDGDPRGGCEIEFQNVSFGYPGRGSLLYEGLNLKIERGQFAAIVGASGCGKSTLIGILERFYDVDTGKVLIDGKDITTFDMESYRNCLSLVSQEPVLYRAIGTLSYNVKLGTPDDKPESSLIAIIGYNTMCGSKGVGLSGGQKQRVAIARALIRDPKLLLLDEATASLDTESEKIVQKAFENAAEGRTMVVVAHRLSTIQKADVIFVLDDGKIVEQGDHASLVKKRGVYWQMVGILPSGGLTLLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSY1</accession>
    <name>A0A2T6ZSY1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1083693</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSY1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSY1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="318" mass="35229" checksum="259C9FB09EC9A37C" modified="2018-07-18" version="1">MHHTQNSDPSIMTRRSMGTRQRVSRACDRCNQLRTKCDGQKPCEHCLVFGLQCEYNREQKKRGKASVVSGTKQRRSSSTSLEGSHRSNSNRIPTTPINTSIQAHDSSSSSRSPVSLPTSPLYHHLSTPGDRDGFQGDYVCMPSGTQSPQSRTSTHQQYFKQEPDSTLISFASNCINEKGRNDPTVNSQQPPMFQTPDWASSTYQPYYRGSDIFDPSKISPSSVLPINHQALPYVPLCAGCQVNPALRLYPGSLLWLPQYGYSSAPRNSSVSTVLEDEADACLAGRHKAVMEDAWDTGDISGRRDLHSLDVQLGCVDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSZ1</accession>
    <name>A0A2T6ZSZ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_58349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000114">
        <property type="protein sequence ID" value="PUU78597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSZ1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="69" mass="8013" checksum="99D7CE4927E067B5" modified="2018-07-18" version="1">MIFEFTHLLTQEHGKRKGGGPNEQLREKAMITSIIHKTAPSERKREMFPQKSKRQSTGPMHPKLRKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTF7</accession>
    <name>A0A2T6ZTF7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1108096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTF7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="91" mass="10691" checksum="B6B93F3CF7D23713" modified="2018-07-18" version="1" fragment="single">MTTIYRFFIRTQGKFIPHIRPHTPIIPHIRQLSQSMKYALPKSPYERPFSDDVGARPKPIPDRSSIEDGSVLKKMLWDRIHSNEENLNNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUP7</accession>
    <name>A0A2T6ZUP7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1100933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUP7"/>
    <dbReference type="OrthoDB" id="5398841at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="137" mass="15715" checksum="9AF134584D51C415" modified="2018-07-18" version="1">MLSNLFSLFHSSKSATAPTSRYRPPATMGEEHFNLLAYLQISVRDESLQCEKPSAAEMLHGTNESNLRKQGRLCLTFALKNYTSISAPEKIRIANELEQAIDAAYSEEDYRHRIYRIGGYLRKPTAPPRYLNWRIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUX7</accession>
    <name>A0A2T6ZUX7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1082100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUX7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="131" mass="14611" checksum="F65257DFAEE49B51" modified="2018-07-18" version="1">MIPPSRRYDKEGEKEVRGCGSIWIQIRAYTRLSRTVHLRRQLEYEYSTAPDTFQSSPGTGPLQVLALPAVLCSSNIEHFTHWAKPGTLAPSVSWLRYSPTVTAKVSAIIGREESFNMFKGIGTELNSLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUY3</accession>
    <name>A0A2T6ZUY3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-arabinitol dehydrogenase ArbD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_979970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUY3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUY3"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37576" checksum="D5DE216DB7B97845" modified="2018-07-18" version="1">MFRSTPLLLRRARALPRPSSATTLRPTARSISTIHPLRKDHREIKPGQFARTDPSITMEYPAEKDMPSSKPPWRYGQMSKSFSLEGKVAVVTGGAGGLGYVMTQALVEFGADAAIVDLNGEQAVESAKNLLEHFKSENPDAECLPKITAHTSDVSSPTSVRSTISEILAQHNSHIDVLVTSAGFTENFKAEEYPHDRMQKLWGVNVDGTYLSAVEVAKHMIERKRPGSMIFIGSMSGGIVNVPQPQAPYNASKAAVRHLASSLAVEWAPHRIRVNCISPGYMLTALTKKILDDNPDLKAKWTSLIPQGRMGNPEDLKGPVVFLASEASNYVTGADLRVDGGYTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUZ3</accession>
    <name>A0A2T6ZUZ3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_842449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUZ3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUZ3"/>
    <dbReference type="OrthoDB" id="5408878at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1214" mass="133981" checksum="5C70125D96B28B2F" modified="2018-07-18" version="1">MSGLDRKSTGDLKVAAGRDPSKPRPSSTTPGPSTPSAPQPSSIPRLTPHNRQTSTPTRPTLYRNEVNTNSNNQNNTEATGVGLSVGLGSGGFSRASRPSPPGPVNGRNSAALRRSTSAQYKFPGRSNPSVTATGSPARIPVPSNRKRGLKKREGSQDGISNGSASSSEMESDTIATKDFFKENKGSRPFNARELYATIFNKYDPSDTGSVPVRDVVAILRELEEGFGGTKYSILSADGELAVGTAMGEAPSLTLSQSDFEDMVLKMLGFGLVDRLIELQSTNPSQEEQLASHQQPPLNINTSDSENPTFEGLGGGLIRSPRYSSKRSPSNTSAQDDSLFNALHSSPRSFAEGDDSAGDDSTGFIGGPPIDSSTPIRTRKPVNFPGSGSAPEEQSLRRRRSANTEETKGEEGRPLVANPMWLEMSLEPAALSGLTVENLRDLLQEFRQLWEDFETRRRRLEEVDRKLDRANQRYSELVAYSEQRYDTIESENQVLQKEKERLAEEAKKLESQCTKGTIMIRTMEEEIAKSETRIEELERSRRQEVRRREEVQSQLQREVSTMKIDRVKLNELERMNEKLLSEAKNYIRDGEQLQVEINAREEELNTKERDIIDRDIRIENLEKEVNKIRGDYRALESQSRAADRVPRGSVRITSKRLGEEIGSFEPEEPQDMSPYGSLEDVFKDYPHFRPTNLQNVKDILPEIPQYESLEQVYRDFPEVEELTLLSQPEKGKDTDLPPLSDHVTSGMGGQNTKGVSPLAPESGLHARHLTAIRQSAVHALSLPVGQNVQTHLISQHDTGPGITGSRIHDATTRSVSRRNSEARNYQDDETERRGNAHGSDGAIGIHEPDSSPDEGGRGDRAGGGGGGGSEDPDDSSDGDDGGRRGRGGRGGRSGRGRRGGRGRRGPRDPRGEDGRGHWVGQFRFTSIDGEYIECIRTTLETRAYLQDLADKPRLTLADVEFLTNFISEQSSPPDQVILQEIWGLASKAERAARRTLRQEAWPARGEKSPFGLVSVNSPFGIFAWPWRQLWDIAFSLDDADYELPGTNTYQDFINEQRVRTTQGGNDDDNTDPAATAQPQSGGGPGVRAKLIDNPVLPSRPHQAPVASILRAGPKPGAAWGILTLLGLGLVLTLAIYNSLIFLRMRSDQQSWEFANGSRSSAGPFWSVENSCWSNCLSGVWGGSSRSSTRWQQWEWLWTQLEGWMVPSEEAQILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV04</accession>
    <name>A0A2T6ZV04_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_844035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV04"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="189" mass="20974" checksum="0443E0F2FCE83730" modified="2018-07-18" version="1">MRAFILGAEPQTALPSSKMKTERIYSHFALKIPYAFPHVRIVAHPKRTNAIPSQLSFSISPKSSITDAWMSATWLVSFFVRRSRQRRNIQQCCQERRERLRRASISRPGPTSDIPVTVRGGTSSASATLSPNAGSPVRDVAVDDPLSTSRSGTPRFFSLNSGPGEGDVDGRDIFDDFRSLVLSWLKIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV10</accession>
    <name>A0A2T6ZV10_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rab-GTPase-TBC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1125418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV10"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV10"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000021">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000015">
        <property type="entry name" value="GTPase activating protein (Gyp2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="265"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="960"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="975"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115556" checksum="BFB257AB640804F5" modified="2018-07-18" version="1">MFSSLLQKATAFITDVPPASPTSPTSSKPTKTTLFRNHFRLPDSQTPLQEITCELTLPSGDHYAGKLYLSESFLCFSPNPPSSSSTASATAGIGFTLPLCAIRRVERLHSRSYMFALAITTWHGVATSTSSSGGKEERVTLQFVGMRSSCEAFCDRLKRGLRSQMGEVKNLRILVDSCYSEYLLGNSGGYDGVKRSTDGAGADESRKKDRDPPDAGLGMIFKYPGDTRKLRDRSKMRLWAEYLRENGRNVTLVRQPTFHKLIRVGLPNRLRGEMWELSSGSIYLRLFNPTMYRDILQEYDGRHSHSIEEIEKDLNRSLPEYRGFQDDEGISRLRRVLGAYSWRNEEVGYCQAMNIVTAALLIYMSEEQAFFLLSTLCDRLVPGYYSKTMYGTLLDQRVFESLVEKTMPILWEHLVKSDVQLSVVSLPWFLSLYINSMPLVFAFRVLDVFFLEGPKVLFQIGLAILRINGEELLDASDDGAFISILKSYFSRLDESAHPRSDNEKLRAVTRFQELMVVAFKEFAGITQNTIIEQRNKHKDAVLSSIESFAKRTQLRNLGPDSRRLTPEELSCTYDRYFGVLYERQGRLQMIADEMEKLATKKRAAAGSGVGGNGGERGRVGLGPTTGETGMDYDCFREFLTGIAKWAVADSVASTLAEPTQPEQSGFFGSYGGAAAALQRKNLLNPWGAGNPEPADHEFMKRLFRRWDTDMKNQLSLGNVVSGLASVVGGKKDIMGNINYWFELYDDDGDGKVDREGILRITEALLFVTRRGDVGKSDGEEAEWGDERILSAVSGFTRMCFEYADPDRPKEEEDIIKVDKEEDEDDLLELATSSSDEDPLDTPETISPGERSPTTPVPKDNAKANLALDPSNPLHITLPTFRMVILADEALERFFERGFAESFRLIPGSEPQTTSANPRLMARMPSTPLTPGNAKGLRGVLDGIVDEGMRVAAEVRRRMEEMEDSREEEGEEGEAADAKSIKEGDRDLLKGAEADIQEGQGQTDELHVEKGGGSKGEGRSRSVSYGDQVSSGVVEFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV50</accession>
    <name>A0A2T6ZV50_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1082030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV50"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="690" mass="77153" checksum="0CE689F16FE32A48" modified="2018-07-18" version="1">MSDRDPIRKLTCKSRILQNAEANSPTRHLPLEIIQEIYWHLTPSEYDSARLVCKRWFRASLSSPLILYFLRIMNFPSNIRSFSESKLQRWKLGDLRLVFAFAIDQWGGSRFRACYRKTDLNLSMILRNTHIDSGYSSREIEFLNFSKNPGGYMGMVTRTIEGSSKVQRTLWVHGITPIDRPSGPHILGSGGWHEDSGLIPMWGVDERPGKLYLTMELKKCPDQPILGLDIEPDGSEPGIMKIRVRYLNSQESVSFDCPLQIGHTRSGNELYLEDSPYEILCRSPGITYRTGPYRIPGCNTCNNSGPNISQKVLRALFRSLGGSHSCNVPRESMNPLSRQAPRFILGSFASVTRAAQALSEQRATTYVALPQTAPMFHHPEVTHDQTLRLPHGHVIPKPKPPTLRERVGKLCHKVAVPNPGPLKSLKMANMPFSHTAMVMIGDDPVRQMCHRLDISLESETCTVLVTAKNGIIICSLSSPTLDIGGVEVLDARYSLIPPPRMSEKATRITHIAIAPWHEHCYFGHGLKWWNMGICAGYNNGEVWFWKVDMENLRQKLPAPGYFGRHHTEVSPPASDANGLPSPSSPISASLPGSLYLPLPYSTPRGECQSMPLGELVYTTGKKVRQTRVHLPPAGFKKAESWVLGFMPGLMKLSFIGRGKMVAAVTEKNVVIFDMRRGGGYETGSVKGIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV77</accession>
    <name>A0A2T6ZV77_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase group protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1100843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV77"/>
    <dbReference type="STRING" id="42251.A0A2T6ZV77"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="72588" checksum="98E32CE3A7C2CC67" modified="2018-07-18" version="1">MTNTKSKKKKGDEKESNTPPSSSALIICRNKHWRYISSFHGPWLQLPPEVLESLAHSNYQAPRPRPIDPAVLYDLVKIRKLIDDATNLAVRAASGIASSAVLKDGGLLGGSAAGVLGLGIAGGGPAPRLSRERKHRMRELATQKLAKAYKLDEIAASVATMQSASSLEEVANLVLARNPDDPDAKYVHFFHEKIPSRMLAKCTSLKPLDDVISERPAEGAPLRTRAVTKGFKDDFIGAVQDLTHALSISRPRSLHDLGMEVATGGGSSSGGGSSGSPRRTEEEDQPSSLEAQLLFHRASTYLTIACQNIEATLTPKANAPAVPEEVAQAEASKREAAKKAVRTNAKRALRDYIKFLSTFDYTPGLPPETAEEFMRSVEREVNKTSDLNPGSTRSDTKKFLEILYRQTGTGGYQSHTHQQHTSMNNLPPSALLPQPPVYQVSALFTSPQPSTLPPYPSASLTTTNGSTRTSTPNGIPKTSTSSALTAAAAAFLADGGEAITYHPLLTDALHSLLLCHVLIQTPAKEILRHAHMVARLARICDGYPIFLSPAPQLSTWEALCSPAPLPGTPPSPVGDGDVSLELERAAAALVGGGRVMHQHAPPVQPKRWAQEDGGKEYPISTDRAAVVSRWVKEGVRKERERLAVATLAKNSAHANGSGTGSPTTPTTPVVEGVEEMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVD1</accession>
    <name>A0A2T6ZVD1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1192627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVD1"/>
    <dbReference type="OrthoDB" id="10651362at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="265" mass="28817" checksum="5B461DA514F2D812" modified="2018-07-18" version="1">MDVIHKLVQRLNVVGNPTTISEGADGSSSREGGAAEGTTEITHHHLPKTTEYLATHPRTLLPPLSKATCAKAVHAKTLLTQISTRLSDTQTELSALPPLPTLQSNLVDATARATAIHAQLLDLEKMVAEEVRRAREEEVARLEAQVDVEFERYARERRVEADRRREGLETQLREFGVERLGVGKRGGVGLEEVSLDEGVSGGDLEDFFGDGGGEGSSEGGVVREGKGLASTRAKEKAKKTNVKKNVVLIQDEDIADEGDLDKFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVH9</accession>
    <name>A0A2T6ZVH9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-finger domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_979451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVH9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVH9"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="19581" checksum="4DB40EA21A016C52" modified="2018-07-18" version="1">MPPRLRLSHLPRPLLHLRSRTIQTQHPTITKPNVPSPNSSATNVTPAGAADPSTLQESVEAGEVKRHMQAPNRATTWSKSQQPRELGMVGPRFENTIMELQPAPYAAIELIHRQPVRFSEKRVVACDGGGGPMGHPRIFINVDKPEIVPCGYCGLPFAHVHHRKVLEAQETTDYPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVV9</accession>
    <name>A0A2T6ZVV9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1081372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000087">
        <property type="protein sequence ID" value="PUU79605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVV9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVV9"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="96" mass="10034" checksum="8BE98A5E2336FD4D" modified="2018-07-18" version="1">MISLRGKSVLITGGSRGLGAATARALAKEGANILVNYVSDEVSAANVTADISDQYEVKADTVKGDVGAQANCVRIVISVLRYSGVWTLSFLTLFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW44</accession>
    <name>A0A2T6ZW44_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1175160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW44"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW44"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="130" mass="13997" checksum="DFB4030DDCECEF80" modified="2018-07-18" version="1">MGFRVIAINTGSETQEMFLNTLSAEEFVDFAKGDVVANVKSVTGSLGTHAPSEKPFQQAAEYCRARGTIVCIGLFPKARISAELSSAVIGMVTLKGSYAGNRLDTQEAIDFFALGLIKVSFKVEKRSKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW74</accession>
    <name>A0A2T6ZW74_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1124718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000083">
        <property type="protein sequence ID" value="PUU79737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW74"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00600">
        <property type="entry name" value="Sm_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1231" mass="132469" checksum="F39EC03546A416DE" modified="2018-07-18" version="1">MATTATAPSAVTNGASSNAASNAAGGRPQLKGSIAGGSGGGGNSNRRPTQSPIDGAQRRGSSHKPWQTNNQQQKYNGTGNSVSASPTPSQSAAMKNRGANASSGGESDTHDKHMHDRTLYLLMNLVGKPVTITLRNGARFAGILTGADTKSHDLGATMKWVRQVRTPLGDNSDERVEEGEYVGGGLEKAMIFEPKDLVDIFAEKIALGEDETQSQSAHPNGAPAGNFRTDADIAGNLALRERELHRWQPDEKTAELSLEETNQTSGQSWDQFEANERLFGVKSDFNPDIYTTKVDRSHPLYQQRDAIAQKIAREIESQGVGPNMNPHLAEERGVSWGDDSGKDEEDRYGAVQRTPAQTILPQIQQPNNRYTPPALRAPTALPTVPGAPHDPAIISSQLLRPETLQQKQQQHQQPTQAPRPPPPQITLNQQPPNKGSEDISAKPKEKTLLPETIVPKRGHPVPSSVDPSVHSSDAPLPQEVTENFKRFVNSEKERYKKKKADLVQRDRASKLEELKKFSQNFVLKTEVPQDLVPILAKDKSKQAEIVEKAKQNVAKTTSTPPTATVQPSQTTRVPPPNSFAAKNPEEFQLTRQQLLQGFPPTQSRLPRGQQIQQPLLSTRLNQIAVDRRAGHHQVSVRSPVPIPEHPHSVPTGPAAGNIPTAPKSASPSSAAHLRNLSAKAPEFKPNPNAISFTPTLGGPSTTATPSPTTSAHAHSSRAASPSAFFGNKKVKTSQEKPLIADRFNPFKRMKLAPPATPTPKGAPGREIRGNSNDYIEPAFVTLPTWPTTEQNRDKKWEQMFAKPEFSMASSIHSSQPPHVMPQPHHQQIPSHIPHINPPPHIAHQPHPHMPQHMGIPPPHYEPEQHLRQIPPSVMPSPSFHNATVAPYQQSPVAHHSQIGPMYPSHQQTQYAIPSGPSGPAYGYYGGFRGATGAGPMMVQGPQPIPYPAGQFIHHPPMYSPQQPHAYLQGAPPPPPSGSQGHPSPGRAAPMMMHQGSQQGTPAGPQMMQYTLQPGQTAPIYAGQGQQQSELLLHGQSWLPPRPQSTVSLPPVPSTPAAKFAFSRAASPVAPSPRMRNLHLSPQPASATPLLASPLATYTTPSAGGSGLSSYALQRSQTGNAPMGAGGGRGRRQDNGSGSSGVYMASVMMMPASSLVYNAYSNDGSVGMIRGQPHPHHQGGPPPPFYHGPHFPPGGRGNGFGHLQQHQGGQHAPPPPPQSQSQQAPPEDEDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWZ9</accession>
    <name>A0A2T6ZWZ9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1063859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWZ9"/>
    <dbReference type="OrthoDB" id="5401189at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="579" mass="63325" checksum="CCEB2F20C21961AC" modified="2018-07-18" version="1">MPPYSPNYTSSSSSVFPKAILPSIVVISLLVLITFVGAVIIFVRAYKQRKHRRLSQQEKNRPSKMGAGGSIMRETDEGDNVNALKAGRRFFGSLFSRNRETGVSRFQPPVAIMTGESKMSSHNVREIVQGGSQRERGSVNWRTGDAVRIGPGYHARHSRETPDMNIYESMAVPVIPTVGKIERMTGNALSNDLYADRASGAVSPRENRALTHSRSVPEWRKLSRIAIPGTPPPWSLRLDTNSSAISLATDETPVVQDLSPNYENLLGLSPPPRVATALIDRKYPNVAALARANIPSAKPSSLLSCTYSCGNPTVHIATQYDPTSRPRRTLSRSSSNMAPLPDPPRSAAFGSFTGRPRSSKGKGKQSLRDSAESTTPMDLSIPFHRGSWSGRSVLELDVPEDYTKKATLPALPPQLINSSPQSTVPKFATTPRIRTSALGPPLDPLLPPTPSILFSTWGISHGNRSDAALPRPYSASRLSLASIPSTISSFNAVTVPANPIHGLSPTPPRSGPSAAALEERLGESISTLIADTPEVSDFTERELEVEMARIRDRARKASDERRWRRREEERWRGGDYSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX52</accession>
    <name>A0A2T6ZX52_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RhoGAP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_976344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX52"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX52"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="924"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="669"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="754"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1179" mass="128522" checksum="7F64E9DCCEBFDE91" modified="2018-07-18" version="1">MDSPELPPGSPMFDDDDEGTYPCKGCGKILEEGKAFELSGNRWHIECFRCNKCQTLLDSDANLLLLGDGSLICNNCTYSCTACHNKIEDLAILTGDQAFCAGCFRCRNCKRKIENLKYARTSQGIFCMSCHETLMARRRKRGKVQKTPTMGSSAPSPMLSLDKSLPSLPLSPRPRPPVNRTTSSKSGHTPDQLSPLGFSASGNELRSAPRSHRYSMNSQVSELSADGAGYDPYSSFIPVVLDSSSAPPVTLPSTAYRPNRSSSYDPYYQERSMRESAGNARPSYERKIPELTPYHETEKSRRLPPHIASQEKGRQVPGSGDGMDMGRRSGDSDRNGGDKKEKLYFNKDLTSAYSSPYISREPSKQGPDSDTASAKSKSTVLAKDSPGNAQDRENFKLGEVPRERKRSLGTPRIMDGEELDPQDVSISFLPMDLGTAPSVAAPEIPPRGDSYNPPVSRGDSPAPVARKPADSESPVHSASSSGHSQRSHGTSESNASAITAAESPEVGPGAKDITDSRPQGIKINTTTTVSNITYQQDPTFSSQTTLDQKPGAPQHPSAAHASGSSGLSPQGESAGSDGSVLPPPFKSPVSDLSMEEDIARVFGGGDPSASILRRVSNAVRHGRSFSDLATRTGSPPRWPRSPSGGDPGYLPFEGDITSPTLSLGGKDDTLALKHELRRSTQRIAELEARLNNTASAKALDSNIAEKRNTVALLETERESFLRELMVIKERVDAAKDGQPLNMEELKSDLIHGLTRELEDLKMTLKSEIQSLVAQRDQLTEEVENFARLRDQAIQDTEQLNLKNAQLADLNNELTRRIQGQFKANKAPVNGLGIYTGNAADLLDTKDQNEKRPSTATATSVSSSNMIGQTNDTTHIHHHHEATEVFTAQKVTSLKNGPQIKKTFWKKGGAVMKGAGKGVNKLFAGSDQREGWPSDHPNGVDSPGSLKPGGPDAPGGKIFGTQKKWMKNKGGQNGLGAAGSSATISDGVLPLFGTDLEQRSEYEGNRIPNVVQKCIQEVEVRGMDFEGIYRKSGGASQMRHIQEAFERGDDAPFDSNVDICGVTSVLKQYFRNLPNPLLTYDIYERFVDTTTVFEEETRIKIVKDLVDELPAIHRDCLQFVIFHLARVAARRDENLMNARNLAVVFAPTLLRFTSDEREIADMHAKNNAIQFLIDHNESIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY61</accession>
    <name>A0A2T6ZY61_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1079629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY61"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY61"/>
    <dbReference type="OrthoDB" id="360689at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047865">
        <property type="entry name" value="Ribosomal_uL10_bac_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="308" mass="33260" checksum="2D872E57113B13FA" modified="2018-07-18" version="1">MALRPLPFLRLTRTYTGLASSSSRSPSIPTDATLPPPTLPGLSPTQPRTVKSPLTRKTQLHRTYLSLLRSTPLMIFFQHNNLRAVEWIALRRELLFGLRKIDPESTLAEGTRITVLSSALFAASLRVAEGYDPQHKRSSEPGGSKLIAKETEGLKKTHPLSPVFTAPVAVLSFPSVEPAHLKTALDILFPLKNPKKGLDPLAVSGLQKFVLLAGRVDGHVYGRRVGEGRVMDVDLIRVLALLPDVNTLRGELLAMLRGAGGADLVMNLGNIGAGLTRTVDTYRKMLSGELDSDGRPVEGKAEGGGKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYE3</accession>
    <name>A0A2T6ZYE3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_974542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYE3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYE3"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="7"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="226" mass="25775" checksum="D6EFA35C885CE26D" modified="2018-07-18" version="1">MADERKIAERMLMNELKELSKENWVNAEPRDGNLFLWDIALIVVNPTSLYCGAYLKAELKIPKNYPMSPPEFKFVRPLFHPNIYPDGKLCISILHAPGEDETSGELASERWSPAQRIFTVLISILSLLDDAEVSSAANVDAGVMLRKEPEKYKKVVKEHVETSKRDIPAGFKMPSLVETKPPEKEEVDDDFWCEFEGESDYGDTSDDEDMVFGMTPFRTWSMVSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYF2</accession>
    <name>A0A2T6ZYF2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1079128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYF2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYF2"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="256"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="502"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="572" mass="63011" checksum="468C9A95C63AA766" modified="2018-07-18" version="1">MKRKRTASASPRDTPTKPSTTVPTLSSIVLNLPAETASSNTPTRPLPLPETPGKQRRTTLPHPEQLNGAGPGTGTESVHSPSPQKRLRTPMTRDGNNTGVRFAESVLSPGDAIGGPVTNADRSARRKSVRRIVSKAVGGGDDSDDEDEDEEDVLARKIFEDDDSDDIDGGLLADEEAIGAQKKRGRNTTTTSRKKKKQLVEEEITAPTDGPDSYFFQNRKARLVTSNSTLASLPALDHSSYFRLIREHGLDHVEDRAYLEGLHKQNFPQWEFELSQGFNLLLYGYGSKRNLLMQFAKRIYRSPRSLVVVNGYVPTLTIKDVLTTVAKAIIGPDHTIRLGSNPNDILDTILSILDTHTADDQETEEEEEEYAPITHLTILIHNLDGEPLRTTRAQVLLARLSSHPKISLVASIDHIRAPLLWDAARVSQFNFLWHDATTFAPYSVESSIDDSLALISGSGRAGGTKGVKFVLASLPMNAKSLYRVLVSHQLQGIEDGAIGAAGEEEVGVEYKVLYQKAVEEFICSNDMAFRTLLKEFQDHQMVSSKKDAQGTDVLWAPFKKEELETILEDLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYG0</accession>
    <name>A0A2T6ZYG0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1079095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYG0"/>
    <dbReference type="OrthoDB" id="5382020at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="440" mass="49043" checksum="CB01DB8C3CA7355A" modified="2018-07-18" version="1">MAEIFAQLLSIYDGLIKAPTRERALHNQLWVERAIFLAWGRAVGLCADARSKPMASDFDDRDLLFAAEITMNSVVEVCADGTTAWRNFGVRKGGRGFFRKLLWKTTEEEDEAWEIADGRKFKDLVNELRRVNCDLERIVPRNCASAHPGELEFEDEDEEEEGEEDSLEEDAMAGIPPPAYYHPASAPPSPPASISLPSSPSPLPSNRHKPRRSVDLPPALAALLTTYNMTVRTYGPSAPETLSIEDLLWHNHFSQPPAFSAAHTAQITHGRDGPETIRALHSLARNLSDKQDFTMALPLYTICLSRETRVYGNEHPQTLRSMSGLAFAYQNVGKDEDALEMYQRALSGWGDVVNVYTVRARINVASIYADNGRFGDAEEVLRRTVQDAGGKLGGGHESTKLAMHNLGFLLRALGRGGEAARVCECREWEHERVDCPLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYN6</accession>
    <name>A0A2T6ZYN6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_974340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYN6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYN6"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU80607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="598" mass="67231" checksum="DB586A40BBE9A17F" modified="2018-07-18" version="1">MSSAPLNLSHLPPTFLLPTRLVQPKANEISSQLRSCKCPLTSNPADASLFVGDINMPKRCEFELRGRGLSVSSKMSPDTKKVKVVKLKWFTESYENSKLLPIDEYIVFTGYVQPSKRPSLVSSPEQNEKQKSALEKDAADRQLRKEILERARGDQARYREEKGRDTRDDIRKLQDMELLYATRRQRKGIDELMTISKPGSKNTTRQSTPEYEKMREKIVSRGRPRLLKEMPDWAQQHNKYSCCRPTPLISPNAEFISLLNTIKLSRVLTSDGVGIRAYSTTIATIQAYPYPLISPSEVSLLPGCDGKSSALFQEYITSPDHSLAAVRELEKSPSFNTLKLFSSIWGVGPAGAREFFYDKGWKTLEDIVEHGWGQLTRAQQIGVKYFDEFQSPISRNEAREIAAVVGKAASKLRAGMDYTIVGGYRRGKMEIHDVDILLSHTTHSMTTGGVVKELVSELEVSGHITHTLHLGRELNNTTTVNAHRYGFDSLEKALVVFLAPTSGLHRRVDIILAPPVSVGSALLGWTGGTTFERDLRLWCDREHGWKFTSEGVFERVTGRRVTGIDGTWRVGEKMVEAERRVVEGVGLRWLEPCERCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A094</accession>
    <name>A0A2T7A094_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1168212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A094"/>
    <dbReference type="STRING" id="42251.A0A2T7A094"/>
    <dbReference type="OrthoDB" id="10667709at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="405" mass="43255" checksum="158F3F61B84370F1" modified="2018-07-18" version="1">MNPDTSNTVAPIENSGTPAASSEEGIAYQELFTEAATETIGALEAGLYGLLTGSISMVWDAIVKLSEVVKKEEEGKEEKEEKEKEKEKVMKAMGKMRVAMEMEMKRKMGIKEREERDDGGVATTAVTTTGPTGTQIPAPQLADHQSPGNPNTAKSVTPSSIMRRKITIADKVTKAPHARIAREVSQGSHRRSKRIIESTQNPGQGKLPVAATAQEDGSAVAAPVEKVIVDGMNGEIVPGAEAEVVMEKGKEVTIEGRSQVLKPRAGGGVKKKGIVASLSRRIRKHSNSGGMGKETENQSITPPTTTDKATEARRTMALHQVPHGPRRQSVRIIEAMQKSAGKEGGSAAAGQVKQEETDKAESKREIAIAVVINIKSPILKPKGGAGVQKRVDRGGKGRRVKRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0B7</accession>
    <name>A0A2T7A0B7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavo protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1043559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0B7"/>
    <dbReference type="STRING" id="42251.A0A2T7A0B7"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="203" mass="21647" checksum="A99B520380DD9993" modified="2018-07-18" version="1">MAPNVCIIIYSLYGHIAQLAEEQLKGIKAAGGQATIYQVPETLPEAVLTAMHAPPKPAYPIITAAELPKFDAFLFGIPTRYGNFPGQWKAFIDTTGGLWAKGELYGKYVGVFVSTGTQGGGQEVTALQSISTFAHHGMIFVPLGYKNAFGILADASEVRGGSPWGAGTFAGGDGSRQPTEKEKELARIQGQTFYETVARVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0K5</accession>
    <name>A0A2T7A0K5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1077571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000048">
        <property type="protein sequence ID" value="PUU81205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A0K5"/>
    <dbReference type="OrthoDB" id="1879at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17935">
        <property type="entry name" value="EEXXQc_AQR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000507">
        <property type="entry name" value="Pre-mRNA-splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048966">
        <property type="entry name" value="Aquarius_b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048967">
        <property type="entry name" value="Aquarius_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032174">
        <property type="entry name" value="Aquarius_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026300">
        <property type="entry name" value="CWF11_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF5">
        <property type="entry name" value="RNA HELICASE AQUARIUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16399">
        <property type="entry name" value="Aquarius_N_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21143">
        <property type="entry name" value="Aquarius_N_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21144">
        <property type="entry name" value="Aquarius_N_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038901">
        <property type="entry name" value="AQR_cwf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA helicase aquarius N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius beta-barrel" evidence="7">
        <location>
            <begin position="496"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="RNA helicase aquarius insertion" evidence="8">
        <location>
            <begin position="713"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="4">
        <location>
            <begin position="811"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR038901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1384" mass="158778" checksum="6F37B00BACCCD20E" modified="2018-07-18" version="1">MEKFDKTPVGAIEEARPTVADLHGGNLFAQAAKKYWLTEKPAKFKPEALKTEFYDLLEKDGFRFRSLLILENLQFLEKFLWPNFTETASNHHVVLIALMVNVKRRENLNVWEYISLLPEHFPPLFRRILSMTIDHGIPLFIRNHLLTFIVTAFQSLDSGLVRKECAPLVSISIWNNLSNGEIRDARLEKYPQTKKAWRAAGKRFDSADDSTKDRLRFDRLWLFEMILDFLNLMYKPSDQQEGDEPKQILNYCERFIELLTDLESQMPTRRYVNFLLKDLHLLTAIKLSPLYTNSENGLFRDLYALLSHYINFSIDDHTGLQLSQEESRQIHNADLAKLQRTAFKHFKDKLTILALANYGSIGQRDELASHIAELEDGGVVELCRLLGLRTEYPQKVVMSVDRAFLTEAILLCHEKRKTFQEQAKELPVLPNQDTLFESSLLRNEYYDGSGPLAIPKLNLQYLTVGDFLWRSFILYRCEAFFAIRRDIEDSLHRLAPKLSHPSMTTQFHGFSKMALLITRPSILETAPPKVGEEKPAYVRAEISLDYTRLSEDVRRDWDSLRPDDVVFLLAVKGIDEGDRMITNGSPDKLNVAEKFGVKCLRAAEVVQLLDQDGRPIKTGDGQARRAGGRRRLHVRLDPEMYKIDADDLKAGKPDAYDSINALIRRKGRENNFKPVLESIQELTQADVPMPTWLQEVFLGYGDPAGAHYSKLPNQPNLLDFRDTFLDWQHLVESFPGIKLKPKEGLQEGCDPPYVISQRTAAEQPKPAKKRRRGQEDNSDKEESLEVSTYKLPNMGPYPVDVPRTNHIKFTPTQVEAIRSGTNPGLTVIVGPPGTGKTDVATQIISNLYHNFPTQRTLLIAHSNQALNQLFEKITALDIDERHLLRLGHGEEELKTDTNYSKQGRVESFMDNRVKLLAEVDRLAATLGAPGAHGDSCETADYFNLVYIEPAWERYQKVLSEEGLTLEKLYGSFPFHQYFSNAPKPMFSHDLSLEEAIEVAEGGYRRIGKLFTELEDIRPFELLKTARDRQNYLLTKEARIVAMTSTHAAMKRADIAKLGFEYDNVVMEEAAQITEVETFIPLALQSPKKGELPLQRVVLCGDHYQNSPIVQNIAFRQYANLEQSLFARLVRLGVPTVNLDQQGRARASIARLYNWRYRELGNLPLLELQPEYQTANAGFRHEFQFINVKDYKGQGEYEPTPHFIQNLGEAEYAVAIYQYMRLLGYPAEKITILTTYLGQRSLIRDVLNRRCAKNPFFGMPASLTTVDKYQGEQNDYVILSLVRTKRVGYLRDIRRMTVALSRARLGLYVVGRREVFESCYELSGAFSRLLENKSDKLEIVTGEMWPTDRRDRPKEGTEMENVEHMGQYVYEMTVTKVESMRPVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0M7</accession>
    <name>A0A2T7A0M7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1077472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0M7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015539369" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9528" checksum="C4F70B840FBB2B05" modified="2018-07-18" version="1">MLLGMLLFLLFHECAEVMKDVSLMHGYENGKHRGCRNEGSLCGAFLLFRNNTECFFSFVSLRDRQDDGKTCVDGSGNVWCLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0R8</accession>
    <name>A0A2T7A0R8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1077564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0R8"/>
    <dbReference type="STRING" id="42251.A0A2T7A0R8"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000164">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="713"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="591"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="810"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="846"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="932"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU81320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1043" mass="115152" checksum="3973539DEEB8D9B0" modified="2018-07-18" version="1">MTRLQRQLMSSDMSEPSVSLSFANNFWGKDDAGVGPLLQRMHDAKTTCEELKAFYTARAAIEDEFARKLLALSKKPLGSVETGTLKISMDVLRAEVESMGKAHQTTADQMKTELEQPLTDYSGAWRERRRIVQGTCEKILQSKMKQTNQVNKTRDRYEQDCLKIKGYLAQGHMVMGQEERKNKARLEKTQAALVTSNAEYQEAIKALEGTTSRWNKEWKQACDKFQDLEEERIDFLKASLWTFANIASTVCVSDDQSCEKVRVSLEDCEVEKDITSFILDRGTGQDIPDAPKYINFCRGDLSDDGASETQEENYSVAQFPRTGNPTFRSASPNPSTSSSSQAEPEPEQVPSTRSRDRARREPEGIEYKSQDQASRDHGHREHDRRSGRDHLRNKGPQTPPANREIAGNITPGSRSRRDSQYQQSGNTSTPSRSQRYERERQAAQNAPHNEYPLDGMTMYCRPGNMISDSGSGGSPIARPPSSHASGSDCSNPTSVSSGSEAPPVAGGGGQRSPVKQQPMHREDEKLVGKRKSGFFSNGGPFRRKSKSEKGQRHQLQLQQQQQQQQMALQEQRRMEAQQQPESPVRLPPSLRTRSTWSPAPQSNSPSTSSRHQQGYESGSANRRQRQSQQRPSDEQHDSPEPIDPRASLALNVGGNVFDVAAPENNKGGQSAKAPGEDELALDPIAQALAELKGVTKGSAPSRNTADRFFGLATPAPAATPAPGANSAINAAQRGTPPPNYAPKTSALGLPPPAFTSQQMQETTQRYVNQRDHMLDGPQMPAAMEEAPSRTGSGRQRSRTMENLRTQSRQSSREVSDNQQDRRAASPIPNRSVSPRPQLYGDDRYRSSSPQPVTYNRSASPNPYTQSRPGTSNTNRGQYTAYSQRSPSPLPSGQEVALSGYRSHSPAPSHHSRHDSYGSRGRSQAGSARGSYDGQSSRHSYYNGDNSSQVGVVATYQGGGGQVVRPRSKSVVDTSRQYSRDGRPILHYARAMYVYQAAIPEELSFSKGDILAVLRQQDDGWWEAEIVGVQGRPGLVPSNYLQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0S0</accession>
    <name>A0A2T7A0S0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoporin Nup186/Nup192/Nup205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1077289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A0S0"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1584" mass="176789" checksum="AA801684189A5419" modified="2018-07-18" version="1">MDEVEAARLLLRGQKESQVLDRNAFQSAVFLFHTRRQNILESLRLILSYALNEEIDPEIRRAAKQAANLLASPKAPAAAGGSGSFTEKCISTMASVRGSVQQLREKERHEQTLRLIPPHGFKEDLEVQVRFLMNQHEALASIVFYLVKLKRAAVSDFKSLLGVVKSFEKYDVFAFHHVLPLYSFCTVLCDPDSPINFSQTVELHKYMLNEYKSAPWPLRFVQASVQIWWLSEFNGLCNDPSSAEAPDSATLDYFTHVFSPSKAALEGGAFEFMLAVSADVSAEWYLNSAKEDLHRFLQTRVAPLEDNKLLSIPFKSLVISQFEIFIECFISNMADLLKQMKTQEEEDVLLTQRTCGYDLERFYMMIHYTYLGRRNAGMAFWVDPESNLYGFIVWASTSHMPFMVATFSYMLASLAFGATAAEHTHRFLQDEITPGSKKNRRTQYLSWEQLFKEFQKYIEQLRTRQKAFVPTNSYRTPAIPAETVAEPPPESSMMLDGYLRLIAQVTQESPTSRHWLLHESPNFRIVVALFDLLALQASVQLWDSVFSAITAFLTEKTENLNSQVWIAVDNWALGTPAPPSNALQLGSMSGKPFAQAGASEKLDAIVTAVHPAEAFARLMATLVSPPVEDSLLKDSLPFPETLGSSTRLSGIDPYIDFIVGAVFTNTSLQNLPPDLPLVPEKIDDPIERLTRAQYRVFRPALQSSCLEFIETCLINFNEDLLNIASSNVAVDVAIGASSLETYAKLHPFARVMEHLLTEKCFNVFYEIIKTGVEDLASAGAGAPVPILRTILMTINILDLAIRMQSTYFEVVRPLVKRDESGMRKMNTISTGFPSIEEAILHHLDIVVCLGLYVGSAYQDVTLAALSLLEKLSIAPKLVSTIGSSLGQQARKNRLLGAIEQSPESNRILFNFIQQWEADVDSEETDMRYPQKFAILKLLDSSLASQPNDFTLAHMLLGFGWDEKEGISLSVSSGGIGSGVSLLHSLLADVDTRESDEAGLAYDGGLCRLKNDIFSVLKRLWTSPATSTEILYVLRANKLFSQMLSEQIIQRQTIWDGIPFESDEFFTRGAAASFCNFIGRRTSLFNYIALEIRQLSMQGASTGVSKYLSTLLGKTVLDGQSMTNLHILDLLDFLELDAPASIPTPKITWFKDLNLSAFYQDDPFGNPSHHLPTIDQILLLRRNELGALGVIDTSNDDSVTLEMKALLDYLFAENQLRLFKGANLECLKAWSTLIAVMLEDCEYEASAKALFLLTALQSILPKLESYCSSDIVYAQELSSLAHTLITHLTFDSKTFGKGRASDMANDRMYQLFRISLRCIQSPMATATLREDFYNIAYRYLKGMSDLSIQTNGLTRHNTQTIKASGDRLLEVLCNDAYAGEGQCKIVALLLLETLVGLAADEGSSYVIDTLMRQNFIVVIIDSLKRIGHDLRNTTSKDIDYLMRSFKATAGFLVRVSQTRIGSGYVINAGLFQALRESHLFAVDPDLGVGINDPTALQKYYDLLQDAMRVVTCAILSKGPQNQTAIKLGHQFITENRNIIMTVFKRHAGIGGQRVDNIGDLGELVTLFVLLISVTSFVEGEERSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A133</accession>
    <name>A0A2T7A133_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_971761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000045">
        <property type="protein sequence ID" value="PUU81438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A133"/>
    <dbReference type="STRING" id="42251.A0A2T7A133"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052972">
        <property type="entry name" value="Sacsin_chaperone_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600:SF42">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="895"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121281" checksum="045C3C0D8D8D5E74" modified="2018-07-18" version="1">MALQSDRQTPISEEKNDRLGGLKWNNWIFKEGIVNLYLLFLRHLMKLHGTAGYRFWPTPPSELTNPDHVSSTISTEFWKKAGESSFDLYPQIPPLLSTPRRRQLQTSENLSIKKTIFNFLSTEQSKFIIPLLVQLGITNIATPPPTIVKGLTKATTDEVSLLLVTPVYVRDLLRNPTRCKLLQDHWKKDPGTLMRNINRLLSFLLKDTSEDCLTGCSLLPLEGGSWGTFSPNPISQIQYFASSTPLERSILEVAAGRLVSEGLGGIVIDGLLEKGMNISPLTFDHIASLCPLVESKNPEYRKAWLVNVWEYFRQRVTKDPDSRDKYLESIESLPLYCGSVVGEQDSLRFLTPLSFASGSLPAIVDPRTPFLERGKATLFQALNGLILVDKSTFPTINTSAESVEQPSGACCLVKAIGTLPFTVPTIHSLSQVFSSVPMEGIKALSELVLPHISDLLGRDPTIVSTLKQLPIWPVASSSSFQSAAMLKLAPHTTLSLITMIDQTTFLKPDLAFKHREDLRKLGVQQLSYLDFLNEEVGLARGYLPAENIREYQRCIEMVYKENPDVFRSCDLAVDGDLRFCRPSTLYDSSVPLFQAAFRDQQRSRFLHPELAMSHVWRDLLIKNVSGPTYIKCARSIERRNSQTIPDSQIESDACTVFDHLCYDDREMHSWSEWKSLLEIRFAPIQETTASWDQSRLKNQQREIFRQRNKLVAISEAVDPRMEGISWAVKPVLRKQMGSLAFSMITSKKLMVRPTTVIEHLEFLASHCEEITQNELQIRIPEIKEAYEHLEQNMHTYTIQESALIWLNVENEDLGKMTREIFRNSWSCSRNLCLNSNYDSGEIKRVRSFLGRFHSLLLHANVSAIIPPDSPAPVTPTTQSPILEGLLELRERELLFDITITAHKPAMLFQTLQIFKAHKIVLASVSDYWKTMLTSTFKESSTPEISLQDDPSTIKVLLDYIYTNKFVEPPHEDDVTRQLENLLDQLEKSEKWFLPSFKRSMENYLSDDHWIRPETVKSILRNARTCNADRLAHVCEKYIQNNRAIVEREAPKEEYESQGYGFRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1X6</accession>
    <name>A0A2T7A1X6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1121873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1X6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="80" mass="8815" checksum="D042A65B7BE6C18D" modified="2018-07-18" version="1">MSPVFLILISGTSCEGLEVEHQLKFQNEGVLKLKERFEGLQNTIGSVLSKTASRMLPRTMAALKKPKNLPNELVASDSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2F1</accession>
    <name>A0A2T7A2F1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1062263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000036">
        <property type="protein sequence ID" value="PUU81923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2F1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="18254" checksum="F0B0F40EADBFE963" modified="2018-07-18" version="1">MSSNSDSTTWNEPNLSILGTPSLFCTWLFNAETSDDDDANISFPNRPLTTSTISTILASEYEYLVDTDSEPCNSTPSPYSITNLGSSTPSNTTSYETPISDLGPKSSNIPTLCTEVTIALSDKICGLRHFAHWYYQKISTATRVALSMVYRITHSLVTPSYKNMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3D3</accession>
    <name>A0A2T7A3D3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1121131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3D3"/>
    <dbReference type="STRING" id="42251.A0A2T7A3D3"/>
    <dbReference type="OrthoDB" id="5407293at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009880">
        <property type="term" value="P:embryonic pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU82229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="456" mass="49582" checksum="FD917576CB51EA07" modified="2018-07-18" version="1">MDDSNWEPKFPPWPDADYRKEFAHILSEFIVDKDGKYAAVEPGVLGPGVPNHDEILSAFAECVKQFVDELSRRHQPSQQFEVENYAIGRFFLQSYPNEEPFNPLALDALGGFGPSTAGDPRKPIRELHRQGPVQADLYPPAVFDYEGFPRGTHGANLQEQVETVTEIMSSRKSYVEPFHQDGGLASLSHFPTVGSHNPGRSGGSALGRRQRTYSGGESTSAGSQTRRARIKRDQPPPKTAADEAGQSSRSFGANARSVDESSRNTTGAGTVSKEGFKHECGLCGERFEFPARLKSHMETITHAARRYRCDLCGSVFSRKSSLKRHQEAATACKSKTQSGNDSPPPSASESGARDAAFRGARPPSMASPNHSNVSPSVAGNQSVSSQNQYRLFGPASGPRTSLGGGGHFSQMARESSQQHRSLQPSVASRSSHPPSSAHSYINPRILHPEMNDGYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3E6</accession>
    <name>A0A2T7A3E6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3E6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="17213" checksum="F969858D63EACA94" modified="2018-07-18" version="1">MRKRFLLTPLYSDAATPQIHTFHSYWRLIETAAQPSVTASMQPATSGLIFVKHVKPVEGRKLEGNVQKTRIHEHDPEKQGSDRDLVLRCYCFGGPDFCSPTTPLAFEWEFITATTPDQPTRTNLSKASKKPEMQTNASIETKRRYQPSFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4V4</accession>
    <name>A0A2T7A4V4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1105584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4V4"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="267" mass="31739" checksum="1928B1C5FD9D6368" modified="2018-07-18" version="1">MQRFSESEATLCRECEQKDILIKELEEEKATLIKQCEQKDTLLQWCKEQMTMSFERCDRQKAAFLREFEQEKAELPKLKLYEEWRYKPLGYSVGVDSWMKKLDEASKEALRRDREIFNQKVEQNPDLFAELLKEKRARQKLENTLQMRGLLRLIVDRAKQHNIIRDSPEAEIQEALNRLAQTREFTKILQHEAQARRLDTTLVMEYFHYIDSELSKPLAFQGPPITVREADFNDFDRAVLVILLKVQSSWPHPLLNWTEETSCKEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A555</accession>
    <name>A0A2T7A555_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1190033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A555"/>
    <dbReference type="STRING" id="42251.A0A2T7A555"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="119"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="292" mass="33612" checksum="B560471D4925E8DA" modified="2018-07-18" version="1">MPPTDRSHRPRNVFFYDSTHPDVALGGFVQNGSITEANFLDILAILLVVEGSPIRVQERISSHIVSRTDVPLKRGAYDIHSEGSIRVSDEPWIYRLTPHIVTRGEDKFRHEIGNRDQKCVISGLSFPESMFRTYGLIFFEAVHIFPREHESLWNQNNYQQWITDMDDAAGSSKINSAQNGFLLQPTVQQLFDQYLFSVNPDDGYKIVVLTFDFLGLDGRILDPVCRNPTDPHHVSDQALRWHYRQSVLANARRGGEPIFEHDFPLETDEIHASPYGQERFELEMAFRLREVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5G2</accession>
    <name>A0A2T7A5G2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1119955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5G2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="202" mass="22446" checksum="35592DAE3907FCAE" modified="2018-07-18" version="1">MEINSNLTDVPGYSNAGHRRPFGSSHCLPSPATSSDDPMHPPHSQAPSAHLEYSQPAHLASIQSAGSFSSLPTGSIEKTAEKGGHKDCRGEDSDEENFPDETQTEATVEAAVPSLVSTLQSKRKRESDNKQAQQQLQSDAEKYPLFCSFLAPKGSKIPVNRYQFLNAEKDILRYLSEKGKERQMENPERKYLKKSKERRNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5V8</accession>
    <name>A0A2T7A5V8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1098806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5V8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="99" mass="10338" checksum="4A0FBD02AE9E054B" modified="2018-07-18" version="1">MSAPSFTAPKTHAIRKPTGFLNLAPVQSSSFPKSPSLSPVTGPLSAVVDAPPLSPLQKAIHRSSSTSSVGSATEKRRFLKLGPVHWGGAIGENDYAIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Y0</accession>
    <name>A0A2T7A5Y0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_214369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Y0"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Y0"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="177" mass="20452" checksum="D5378AE79284F626" modified="2018-07-18" version="1">MKKQPIPQILYKFLFPTPGPKDPATFDQFVNEVLESEIRAEIEEWYNCHTSEELEEVYPGWDYADSNVRMRLSRYKGHGRLFKAFDKLGLSAHEINSVVTWHGTRWELEDWEAETGSSRERDPSIYDEVEDYDYDDEEDEEEEEEDDGEVGAAAERREGAAQDSVTNANHRSASGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A704</accession>
    <name>A0A2T7A704_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_963623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A704"/>
    <dbReference type="STRING" id="42251.A0A2T7A704"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="360" mass="38084" checksum="6DF294DA2EBC3121" modified="2018-07-18" version="1">MDSNYLHPSGPISTGASTSTTPTPAAGTTIAATILANNTASGTAGAGVKRAHASSNAISNKSRSAANYPRKRAVSACLVCRGRKTKCDNQRPQCGFCKQTGAECVYEAEKLATFDAASLAILDKLSRIEAMLDSDRGSNNQQHTPTSHPSPHTSGSTTSGGAGPIPPLPSLAARSSSPRNAGSKPRPDASEIFPVSLATASGSRVEAVLQWPIFNGQFCLEDLLAPVFADTRDGDDEDEDEREGWQEGEDMGRGEPEDGYQAHGGSRRGNGLYDYDERLLKQPPGEIATLVQRFFRNVHTKNPILDSAVLDSYVYEIDQHGFGWSGKSCLVVSVFPLHDKIGREIGAPTDGGEGSCSCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8G1</accession>
    <name>A0A2T7A8G1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_652517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU84014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8G1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="213" mass="22988" checksum="59914946A04CC76B" modified="2018-07-18" version="1">MMADIDIGDGESESEDSNGSNNHNTHIPQGQRREQGREYGAAPQDQFNHHSQANPHYQPAPPAQNQGAPYPQGGGFAYPPEPNPNPGTFSPNHSQPHFQENISGHPPGNSGPNQGPRPGQAYAGLGEAQRAIIDAQNVAREAREGAREAREEARRVSGGAEEIGSLFPRLGEGMRSPMSQEEFDEAEEELREETEDAESEGGHALGWPNPDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8T4</accession>
    <name>A0A2T7A8T4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1070715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8T4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU84157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="63" mass="7179" checksum="4672A8BF4AF43FF7" modified="2018-07-18" version="1">MGSPSRIVATLSMIFPSRFRQLPLPKRNRDVGYKTSPSKTYPSYLRGRLRIERHSGMICSALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8Y2</accession>
    <name>A0A2T7A8Y2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1037785</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A8Y2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="43"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="591"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="789"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU84196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1452" mass="162593" checksum="0E75A2227DEC3EF1" modified="2018-07-18" version="1">MLAKGVAAEFLGGPDSYNGVKAVFNFIPPELPTDENSVDEDRLSQLTLAKVASDLLYSILQQDGSLFDACKAELCKQGNRFFTNPSSLWKVLRKTIQDCQTDPVYILIDGVDGLGGSSHEELIRRILGLMEIRTVKIFLSSRDVPYISNNLPHSLHEYKKINLDTNSFVKADVETFIKCKVNAWGWDMELRERAMACLLAKSDGIFLWASLAVKSLSYFHLGLDFDESLRKLPVRLTDVYRTMLHKLFLQGGPQKVLHMIQSVALALRPLTFGELGYILACIEGKGSGGEEKQLCYRVASSEIRPRSEKEIRMYVQSSMGFLRATDTTVSVVHYTAVEYLFDENRKDNLPVLSKSQADLTISWECFRYLHHAFGDPERFLKGAVSRHYNGSQDRSLGQYSQEETLRETPWEMARKNPLGTLTKWPYLRYAAESWFIHARQSIEVSKNKFCDDSTHDWFQHQFFETNDIVRKPWIALCGDPRMEILAGEQTPLHIAVCLGLVPLVEKALSESTKGTNSNCSPLHLAAKFISGAYKILIDRSEPSLLTVPDHDGNTPLHEAAISGHSSMFKALVKKLARHKTYCAEINKKNHFGNTPLHLAFQFDHLEIVELLAKGGADATIKNYAQMTPSELGAKLERGDSLDVLKRDESYWGGRSWRGGVPTGSQASITQNSTGLIITQDVHPQRVDVAMTPLPISTPNFHQPNPETHPIIPYDMTAGEEVSRSHSNDAINPPNIAHYSKNTNYFDNDIGQKLKIGVTAERFEILAWLSPLEPRIKHQELRVRRADNIGEWLLRTDEFQRWCGGAEQDGSEHATLFCCGGPAAGKTYFSSLVVDWLCDKAKEQNIAVAYFYVDFTARGEQFPAHILSSLLKQIVGGLDRIPDVISRTFQIHKKEIGGRGMRVPKILKMLQDVTSLQPTFICVDAVDEFMERQRLEILDSLRLILEKSPNTRTFLTGRGHIQGEIDRHLGTRAATLSIKPNNDDIVGYIRMRLRKDTSLSAMDSGLEEEIIKSIAENIPETFLPISLTMDAILSEETAYERRQRLMIVAESLHSKDVYDATLAQIKEQGEERTWLGMAALMWTSHSERPLYFDELSHALAVEIGSRDLNPERIPSLETLLSICSGLIAIDRQTSAVRLIHPTLWEYLHARPELFGPAHSIMAETCLTYLNFRAIKDISPTLSAPPHSTPFLNYSSLYWGVHARRDTSKEVLSLALQLFSQVDNHISTRLLLADLISRTGRRSRDIPIDDPLTGFTRLHCASVFGITAVATALIDQPNCDLNGRDFLGITPLIWAAICGQEEVAKLLLERPTVNPDKPDGYFRRTALSWAAKKGHEGIVRLLLGWATAKPDGTDGWWGKTPSVLNKVRGRRYVNPNWQDKYGQAPILLAAEEGHGGIVQLLLGRKDIKSDKPDSDGQTPLSCASKNGHEGVVKILLGQKDVSPSQLDGTPLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A905</accession>
    <name>A0A2T7A905_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1111982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A905"/>
    <dbReference type="STRING" id="42251.A0A2T7A905"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="671"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU84203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1196" mass="128757" checksum="F01A9C4636281B4B" modified="2018-07-18" version="1">MSATNSDSKRARLESWGSSSSPLSHEIHHTHSQHFPPQSSSTYSTASPTASFADWQMKTPPQPVQHTLSHSRSHSVPTLPPGMVTGGKNGTSQQQQQQQQQQHPGQSLANNSTLTTSTHTNPLVHNSGPSPNHGYNSGFQTQHHHQPQGQQVSMDGSALTPPPAGPTPHLRNATDQQQVQQLRSFSVSSNSSSSAGHPSHYQPDTSGYYSQQIQSQRQQDLSHPGNLAGNVAIGDSRPPALYENTSPASSATLPPGPSPIMTSGFSTTPTQMIPHQHMSASASGVTSPVVTTPAVGGIPGTMMGNPQMNVVTTYPPRRKAIRAAQACDACRARKAKCDEGRPSCGFCKESQIACVYREVPPPKQDRTLLQILERLGRVETLLGSINSGKEVAAVAAPTAGSGGVSGATAPKEAIAVNETSLQSLQSTSPFHPPTPIAQQAYPQATAGGASVQDHYPHPSNHTEALLEEDEQLSIPVQHTTAAHKLMWWPSIRKNIDEEFLENERYVMKEEEKRGPLRVYGRGESLDSPGSMFEDMDDHDTGFVWDSGIGADEGVEGSWRSSEDSPMEDALPEPGDYMNSQRKSSAYTGSGLTTGGGLKLDHQTILALLNSYLANIHILHPVVDKAAITNMVFLFSDRVASVSAASPTTPYSGAQGPNVGLGLEPTTEGDGFMPSPGLHRKNSSTAKRKRSISGIGPMHSVPSSRGVGPSPQRIPRTLHSALVLLVMALGAICSHKRPVPGPLPPLSNSGFRTATPPFKTSGPSRHGAGSPFHSYNQQQHSGGLQGRQGRELKNIDVIPGLAYFVKAMEITGVLLGGNELENVQICLLAGLYWGQLGRVLDSWKWINYACMGCQVLVGMRLENESSELKKDLILRAFWSCLQLESDILAELDLPPSGISRLEDSMPLPSSITDSSSTDGASEDNPLMWMYYLAQIALRKLLNRAHTSLYKRDKARLDSPRSLAIARELDLQLEQWKLHLPEPLRWEESDPPSADINAARLRAKYFGARYIIHRPFVYHAIHGGNGVYNAPCSSGAFSTSSPSEMSQSSPSATTPGGFNPLGNIAGGGRRISIAGEGERMELAPVSLETSCRKCIDSAIFSTTAFHAFSPDVNRPIITNVFGTAHAQFGNLLVLQAASQSPTLKSMVPQHLLAELFQKTIYWLQTLSPISSALRHDAQILENAAAKSDFQISTSMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9F8</accession>
    <name>A0A2T7A9F8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_960834</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9F8"/>
    <dbReference type="STRING" id="42251.A0A2T7A9F8"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="35"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="713"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="530"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="588"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU84332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="801" mass="89183" checksum="366B62C781E565BE" modified="2018-07-18" version="1">MFRNGYTDQLHSEDLLGVVNKLQDLVFNTIGSDSGLDLPQIVVVGSQSSGKSSVLENIVGRDFLPRGSGIVTRRPLILQLINIPNDEGSSAEPHTREGNSEHPEFGEFLHQPGRRYYDFNEIKREIEAETSRIAGNNKGINRAPINLKIYSPHVLSLTLVDLPGLTKVPIGDQPTDIEKQTRNLISEYIAKPNSIVLAVSPANVDLVNSEALKLARQVDPQGKRTIGVLTKLDLMDHGTNALEILSGRVYPLKLGFIGVVNRSQQDIQGNKSLAEALKAEQEFFKFHPAYRNMAHRCGTQFLAKSLNSTLMQHIRDRLPDIKARLNTLMGQTQQELASYGDMHFSGKEHRGSLILQLMTRFASSFISSIDGTSSEISTKELCGGARIYYIFNSVFGNSLELIDPTTNLSVLDIRTAIRNSTGPRPSLFVPELAFDLLVKPQIRLLEIPSHRCVELVYEELIKICHTCGSTELSRFPRLQAKLIEVVSDLLRERLGPTSTYVESLIAIQRAYINTNHPNFLGAASAMSSVIQNKQEKERKAQAFERRKERDRRKPTSMSNSTGPPMLNGEGGPEYEENPIIERARMMHGRGESRSISPAPGSLESSAISSAMGVNGRPSSPQVHTSPGSTTNKTTDSFLNYFFGKEGAMPATSGAAPRSAPEPSFTQSIRRGMERNEKPAFDMSRLSQNFDDTTPSFVAAPEEAALTEREQMETELIRRLISSYFNIVRETIQDQVPKAVMHFLVNFSKDAVQNRLVTELYKEEFFGDLLYEDDAIKAEREKCERLLKTYREAAKIIGEVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-06-01" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q9C1I8</accession>
    <name>Q9C1I8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1136110</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2000-12" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Zeppa S."/>
                <person name="Stocchi V."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="AF329479">
        <property type="protein sequence ID" value="AAK19308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000428">
        <property type="protein sequence ID" value="PUU73012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9C1I8"/>
    <dbReference type="STRING" id="42251.Q9C1I8"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAK19308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="306" mass="34373" checksum="33574BBF708CA627" modified="2001-06-01" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZA23</accession>
    <name>A0A2T6ZA23_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000606">
        <property type="protein sequence ID" value="PUU72274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZA23"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12813" checksum="A5C8BDD59DA215F1" modified="2018-07-18" version="1">MPQGNDADFIAIEGSPLTCLVTLVVGLLLHTADEWTRHLLDRPAQLQHRLDDQERRLERLEQQFADLKEEFAALQQLVANMRVIVDEVSDLRSSLEELIHDCDALRNLLAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAD2</accession>
    <name>A0A2T6ZAD2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1169654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000546">
        <property type="protein sequence ID" value="PUU72406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAD2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAD2"/>
    <dbReference type="OrthoDB" id="5508299at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="450"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="611" mass="71495" checksum="8DC6CF6B2A4B6EE4" modified="2018-07-18" version="1">MESAKKEDAIPFADHVLETVIETAEDAENWKPPYSSDLCGIWGIVGTIKIKNLFIGLVYHYTKILLPPKTNYIVQEPKAFNWVLSKDLGKWDRQYWFENIAAGPQTPKRKIRKFPDYSNDAYRWLLRVIKDGTLKASIKQSESEDSSNEKSSPQDKKRSKNLSIITSSAELRVENKVDSEDSMDMVEDEEEVEGEKVVEEEEEEMDEEEEEEEEEEEEEEEGEEEYEGEEEEEEEEEEYEEEYEEEEEEEDENEEKKEEEEEEEKEEEENNSEEEKHSKENEEEEKVNSEEEIENQIILTEEGDKEREAEKNEKTYGAKRKRAPSGIGGEEAGRKQKIVILKGEKLSAKYKMMGENQLEEGPEAVQNLFLQMAGEEIAHPLRTDRLWRISEADIEYGSSESEGNMERKELQNIKAAEKKLEEKRFELYVRRKLRKSGKILVDRDIYKAMMKEKEEAIADRQILAMELEELGKKVGEKEQDLVSLKERLREVEREVEKEMRQKEESQKRVKELEERGSPVDKIVEKANRIIEEKGGNEVKITVDNSFNNKEKLKQEILLVARWIASNIVTQQPKIKVIFGNSQVVKEEIEEITMGNSSDRERFLPVYIVKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAL1</accession>
    <name>A0A2T6ZAL1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1097174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000527">
        <property type="protein sequence ID" value="PUU72486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAL1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="77" mass="9088" checksum="6E784EDCE526656A" modified="2018-07-18" version="1">MKLLPRFRGLRILLTLMLLQVCLVSLLMRMTVVMTRKKTYILATGIEEGRVTSENSSGRRKERGRRQKNELQRRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB18</accession>
    <name>A0A2T6ZB18_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1104276</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000482">
        <property type="protein sequence ID" value="PUU72688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB18"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB18"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU72688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="467" mass="50449" checksum="57EE252582CF844C" modified="2018-07-18" version="1">MSLAVFTDIFLYGLVIPVFPFALEERANIPHNDVQRWISVLLAVYGAGIFIASPVCGYLADVSSNRRSTLLIGLLALSGATVLLCVGSNITILIIGRFLQGVSAAVVWSVGLALIVDTVGKNEVAQSMGIVSVAMSGGIFLAPLLGGIVYDKVFSMAFGLLALDIVIRLILIEKKIAVKYLPKTVESSESSPGMDFSGAFARAELDSGSPPGHSGPPKSPCEGSHLIPIPKKAHTPDSRERPVNNDENTFNDIEAGSTVPKKRSRVPPIIRILKYPRLLTALWGTLVQAVFMTALETTLPLRAWQLFNFNSTGAGLIFLAIILPTFLAPLVGWACDRWGTRWVQTAGFILCCPFFIFLRFPDHNSVSQIVLMCAILALIGIGLVLIMPTLMTEISLFLDEVEENNPGIFGSNGAYAQGYGLFNLAFSAELFLRAKRLTTFHKAGFLKDLVGWNTMVLTIGLLPDPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBF5</accession>
    <name>A0A2T6ZBF5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1136602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000458">
        <property type="protein sequence ID" value="PUU72827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBF5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="59747" checksum="4D291A2610CC6665" modified="2018-07-18" version="1">MDAILTEFDLGTEWDELVLESDQLASSVPSTPLIEDPVPLSLVVNLDDYPSPYIAPVNTTGFPSYALSNINLGDQEAVNTPENRLISHHDQGLGLPAIINSILLISKPNDTLKSIPTITQTQISSNALPERKLQVYLQYTPTGSTEQLTKAMELSLPLVWKTVLGVASQILQRPHLQIHLKSKLSSQKKSDPWTTFDNEEDAKNLTSTIRDLLVPRGGGKPQTVDIWFHVSLHMTENNGSIEGDQISQQQSRKRKVAIGTDTISAGKEKEKIAKKSKEEVEQERHEEELQASMKYISEANACERNNPQCKKGPNRCFIRTDGEHCYIKPQLLLYWASALKEKASGVTVRRPPLIPDFERSASRAHSIPAVSSPSLPSSSSTILPPAPQFSYPSALPPNPYSFTPPHSHYLSNFPFPQYNPYTSPMANFSYNMPSQISPQSFMAYTAPKPFAHSSSPSETAGPTTEQIEVCRMATISEFLKHAKEVDSRYNFPAFVSAFEEGRVLPDILPMISDEHLELLCGKNLGATIAIRKMVGRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBH1</accession>
    <name>A0A2T6ZBH1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1136636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000460">
        <property type="protein sequence ID" value="PUU72819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBH1"/>
    <dbReference type="OrthoDB" id="5423608at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015464776" evidence="2">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU72819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="183" mass="19391" checksum="26BE17CDBC6B1CB2" modified="2018-07-18" version="1">MKSSFITFASLFFFLIGAVVAAPTTLESTEIVKRDFQPLDSILNEGYSSLIVKNTAYNATTIVTSADVTAYCNDIIVIINVIVTKCGLIPAGTIFLDINLIASLLFKILCEINYTLQLLLSKCGILGLILLILSLVNGLITALNHLLVVVGGLCGTGLLGLLSTLIISNCGLGFLLLLLGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBJ5</accession>
    <name>A0A2T6ZBJ5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1096385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000451">
        <property type="protein sequence ID" value="PUU72867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBJ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBJ5"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="168"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="347" mass="41314" checksum="CF1ADB0C210B57FA" modified="2018-07-18" version="1">MDYILGVTDNLFFDTIYATLLPTDSLASWAGANDTWKAEYTNPPPIVNDPISHFFGLRPSPRAYESFFQRGDWQRQAFSLFLITWIFGLIVYFIFSSLSYFLIFDKDTFKHPKFLKNQIRQEMAQTMRSLPVMAIFTTPFFLAEVRGYSKLYADVELHGKWYLWFQFPLFLMFTDFWIYLIHRGLHHKSIYKTIHKPHHKWIMPTPFASHAFHPIDGFSQSIPYHVFPFIFPLHKYSYIGLFMFINIWTIMIHDGEYVANSPIVNGAACHTMHHLYFNYNYGQYTTLWDRLLGSYRKPNMELFYKETKMGKDEWEKQVKEMEKVVQEVEGDDTFREYAANVSHKKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCP2</accession>
    <name>A0A2T6ZCP2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1163823</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000395">
        <property type="protein sequence ID" value="PUU73265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCP2"/>
    <dbReference type="OrthoDB" id="5391356at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="657" mass="75140" checksum="D2A31AFEE7587591" modified="2018-07-18" version="1">MSARPQARGAPKMRPDKIVYRYNCHTCKVHFSSSSNHGDHHLAFHGPLNYSYLPYYLLCSPHTTSQQPDMFAEIVSNDPLEPILHCVESDCACPHFEFSSDAHSSEACARGGAGPNLDGAAGSTLAGEELDDDLDIEPTEVKLVPKSGKDEHSMRKRFNKGKFGLKQQLRDEAAGRDLEFFRAYEAADRNLFGQERFEELGDKASTGPDPKQSVTDEAAGEEDKAKLLSPEEEKARLDSWKCEVGLQDLQKEKKKQDEELQNAIDLLIFDTVFDLEEKDQERKRELKARKENSRLHFEDIIEDIALDHEQKIAENERQDLRKTLGKRMTRALGRERDDDMVDGIAFDHLQDVAERSQENNRRREGKRQERDRNRIKFDETVDNAALDHLQALEERSQEHLRRSLGIRETRELAVQHWEDFSETNILDYFQEIGEGEREMERAALGRKQNRKLARVKAENEIEEAVVDHLQEVAERNEEYRRRRDGRRQTRSIARNSVDAAVGNAVDNLPRGPEKPKGLRVGVSELSETEKADTEKRSEAFLMRFQGQADIPGTGGEHSAIQTSQERTRKVVSPTNVYPVFTSPRKRRYEDEEALAQREYSMEGSASVAESSGVTRRRKRPKSSKQVEYDAMVDEMVKKFEASKRSGKNPNVSLSHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCP4</accession>
    <name>A0A2T6ZCP4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1095477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000395">
        <property type="protein sequence ID" value="PUU73260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCP4"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="78" mass="9143" checksum="F8460C818EF91E39" modified="2018-07-18" version="1">MVFYRTSMIFFFFLMIVELGFFRILFANDCGLHCLTCIYHELLFLFPFFISIFIFLCLFVCSLCLGVLGVLVSLVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCP8</accession>
    <name>A0A2T6ZCP8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1104000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000394">
        <property type="protein sequence ID" value="PUU73268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCP8"/>
    <dbReference type="OrthoDB" id="3926209at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="102"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="345" mass="38332" checksum="0952B1FECEA419A9" modified="2018-07-18" version="1">MSDEHDNLAPVAPLRETQASAADTPVITADSMEGVVVETSRFDNNGDGVVDPLFEEQPGEGESTDLIVIKDGDDGDEGEEHDGNGVLARIKRQTYADFLSTPTVTINVGDIENDGSVLSAHQAFLLRSPYLAGICSSYTHDVPASERVVNFPDEDLDAVGCFLQYLYTDEYSPRLVPNPQRPDDTILEALDPDLGVQKDLDGGHLLKHAKIYTLAEKLGMEELKTLAHAKIHKINSTAKGELEYARFVYANTPREDKTIRTPIATYWAHKSHVLRHEAEDEFRGMILEFPQFAYDMLSIVLDQKEKKNKDVHREEREGTEIMAPPGTAEKTRGSARKRPRTSSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDV2</accession>
    <name>A0A2T6ZDV2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1134833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000361">
        <property type="protein sequence ID" value="PUU73626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDV2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDV2"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="39"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="251"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="525"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="782"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU73626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="818" mass="89585" checksum="8CD5BD3A443733CA" modified="2018-07-18" version="1">MADHEEKKKVNLADASGAIHKEADETATAILKKKKKPNSLIVTDAVNDDNSIIALSNNTMETLQLFRGDTVLVKGKKRKDTVLIVLADDDLDDGSVRINRVVRNNLRVRLGDVITVHPCPDIKYAKRIAVLPIADTVEGLTGSLFDVYLKPYFLEAYRPVRMGDLFTVRGGMRQVEFKVVELDPPDYGIVAQDTVIHCEGEPLNREDEEGNLNEVGYDDIGGCRKQMAQIRELVELPLRHPQLFKSIGIKPPRGILLYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGMKARSNIVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILQIHTKNMKLAEGVDLEQIAAETHGYVGSDVASLCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMENFRFALGVSNPSALREVAVVEVPNVRWDDIGGLEEVKRELIESVQYPVEHPEKFLKFGMSPSRGVLFYGPPGTGKTLLAKAVANECAANFISVKGPELLSMWFGESESNIRDIFDKARAAAPCVVFLDELDSIAKSRGGSMGDAGGASDRVVNMLLTELDGMGVKKNVFVIGATNRPEQLDAALCRPGRLDTLVYVPLPNEASRADILKAQLRNTPCAPDIDLKYIASRTHGFSGADLGFITQRAVKLAIKQAISAEIEAQKERAEGGEGADAEMMEAEGDDPVPELTKAHFEEAMAVARRSVSEVEIRRYEAFAQSMKQSGGMNSFKFPTEEEVSGGAESGFGQAGEDDDLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE19</accession>
    <name>A0A2T6ZE19_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1003272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000350">
        <property type="protein sequence ID" value="PUU73719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE19"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="68" mass="7919" checksum="151AF6FD9E3EFC92" modified="2018-07-18" version="1">MPRFVLLISRGAWVALREHWFHLTQETGSGVMVGNLTMWSRRSWIGSAMIRIWIPCCQVRCRVYSGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEA1</accession>
    <name>A0A2T6ZEA1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar segregation subunit 7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1111009</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000344">
        <property type="protein sequence ID" value="PUU73820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEA1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEA1"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="925" mass="96685" checksum="6C4BFD5D842C1A3B" modified="2018-07-18" version="1">MSASRGAVNNRGPGGVAGTGNGVPAAGSGGIDLGGGEGGGSGGELDGNSHDRIRGELAGAEKHSRDSSPMRRNTSSAGLSDSNTSTSTLKKKRKPNVVRSAAPSRETSPTRSGTLAAGSSRNAQPQSQPDFHQPRPNRPLANAPHWPPSTRLAATRTPPPDSRSPALSPQKKGDHTNSNTSPGIPQSVSLLRDREGNPEDLEESGLASGMRTPRSNNSPALETVVEGSLPATPAISTSKTLTEQVAALVNRQQHNTIPEEPEGEKPGGGGTRKHRTDSITSSIAPRSQAESESESGYKSEEKAAYANNNNSSRAPPPSKQFARRPTVMGSDNFSRNMTVETETVSSVPQVAVGAAGVPGGASIRSKKSNDTIRAPKKDKKKPTKRAGGGGPANPSSKADLFARRVAEAVDEANSSDSEETFVYESNPPEAPQRPTSRFHSRTPSATSIQGGPDPRGMRLPLLSSMDGNQSAGRNRMKFVNTSGGSNTNAASDGVAGEASGDRGGGGGGGGSGPSTVVGGAGGSRSEGQSGSGQKEKGGSSRGQNGHRGLLPESPFSSSHKSSAHSLRTSSTLSSRQSASGRHGSGLRNGGNGYGSKKSPRAWAPYEADGEGAGDERVPLINRANRTHRHSRRPGSGTLRQLEHSQPQRRGWFRTYICCIIAVFAVLLIMTGVGGFLFATTKALQEVKVLEITGVLVSKQELMLDLVVSAVNPNAIPVVVGNMDVNLFAKSAHVGDGKGKDGDEKDGDGKDGDRDGDGSAGDDDPEGEPWWRLLSRRKKQARRRQVMEFTLGKGRVTIPLATTSAPDGVDEGTDPPEDLPEQDRQTMLLGRIFSFDSALSFDGSPLRHRHATSVGELRLAKPGNKTEEGGTERWERVLQHPFELIVRGVLKYQLPLSGRVRTAPIGASVLVHPDGATSAIGPGTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEE5</accession>
    <name>A0A2T6ZEE5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000339">
        <property type="protein sequence ID" value="PUU73849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEE5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="200" mass="22425" checksum="BEF3BCFD40DA9F5A" modified="2018-07-18" version="1">MYRKSILLAANRPVKDQHPWLPLSENLEPSSTLLTDIAINYSQTVGTASTAGGGMLSPRGNRVLTYPALPAATYRLLRNSLGDSYRLVSTHHLLHLVLVVKFPAAYVRIDFVEDMLSLLVYVLELARMTTSLDYSYFLGINIWPSAATLLMGLCWGSLFENPIHCSQSCLLKPPPRQLLTFSQRILLPVARMYSYYAYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEY3</accession>
    <name>A0A2T6ZEY3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1103694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="NESQ01000327">
        <property type="protein sequence ID" value="PUU74029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEY3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEY3"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="168"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU74029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="617" mass="69193" checksum="589F3467F2A48C60" modified="2018-07-18" version="1">MTRILCVAEKPSIAKAVAGHLSGGAIRNTRNTGNKYIKNYDFNYRFPPPWGECNVTMTAVVGHTISWDFVDGFRKWKDCPPSALFDAATKQFVSPESKEVAANISSEARNAQILYIWTDCDREGEYIGTEVMDLARKTNPRIEVKRAKFSNIERAHILHAAQHPGDLDERQAAAVRARIELDLRIGAAFTRWQTMLLQTVRGLDGQIVSYGSCQFPTLGFVVDRYKKIKSFVSEPFWSIKVMHKRDDINVNFSWDRSSLFDRMAVMIMYERCLAAKVANVVSVVKKPTSKWKPLPLTTIELQKQGSRFLGLSSQLVMNIAEKLYTQGFISYPRTETDQFDEGMDLPALVGKQTQSHAWGEFAQGLLAGGFSKPKNGTHNDKAHPPIHPVAYVAPDKLNADEKRVYEFVVRRFLACCSKDARGETTTVKLQYGEEGFHTSGLVVLERNYLEVYVYDKWTSSQELPAKDLPPGFLTEPELIALMDANGIGTDATMAEHIAKIIERKYVFARPKGRSEFSPSNLGIALVEGYDNIGFDMSLSKPFLRKEMEVKMKKICEGATTCRDVVNSSVEQYREMFVKASQCSDVLKAALFHPTKDPNGPVAYELGGKAKCLLATAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF04</accession>
    <name>A0A2T6ZF04_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_487094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000325">
        <property type="protein sequence ID" value="PUU74052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF04"/>
    <dbReference type="OrthoDB" id="5508883at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="304" mass="34046" checksum="36D9AF4C0E275C68" modified="2018-07-18" version="1">MVVGLIYNNVDGCSDPYRELDMVKKSLWEAIPHVAPIQTGALAGNTVYTNPSSEPLLSSFQNMEATIKQLVETTNALKKSSDIHEQNTATLQTRYAALEKTSAALEKKSAALEKTSAALEKKSNTHEQRANTHEQRANHQQDELNALRPLKDTAIGIRERFLAGFLEGQAAGQIILGNRAVIEIGNKIAHEGDIVTDISLLKNRMIGYPTAFRRLYGLRWEDAITLLASPHMIEVMNCRATRIANGGREDQWRAQFNELLQWTRTATPEEISSFNANYSRFPYQKGLFRLLTSNPPPRPHRAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF55</accession>
    <name>A0A2T6ZF55_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000321">
        <property type="protein sequence ID" value="PUU74138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF55"/>
    <dbReference type="STRING" id="42251.A0A2T6ZF55"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="115" mass="13441" checksum="2384A8564642C9DC" modified="2018-07-18" version="1">MLDGWLSNSDEQVKTVILIKVSLPERTIHIEKWQYGNVENTQITRGRSKPTIYVPTKIHEIDIVDKKVIGDPLWISFRRVMLRKPNPKRKRETDFVFNKKELARIAADIWAAAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFC9</accession>
    <name>A0A2T6ZFC9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000315">
        <property type="protein sequence ID" value="PUU74208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFC9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015476701" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9318" checksum="4466C5D896393D7C" modified="2018-07-18" version="1">MLSLAGLGSWWAKGVFLLSGHWIGACGWIGEDEWARLGKAIFYSQLNGVCEHDRNCMTPKSKQKARFWRYAITVMLTNVLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFQ8</accession>
    <name>A0A2T6ZFQ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1093068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000306">
        <property type="protein sequence ID" value="PUU74325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFQ8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="20145" checksum="18DC306EFD4FD226" modified="2018-07-18" version="1">MRSRSPLTTAFYAIPSVHRQKDIPIRAFSMALQSLLKGESICRVFLDVWKALTLKPDSGGVRYAITEPFYNGVLRHPICPPPKGHPHTSIFHGATELLKGESICWVFLDVWKVLTLKPDSGGVRHAITKPFYNGVLHHPSCPPPKRRLRTSIFHGATEFSEGGVLMAGFLSTDFIARVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFR1</accession>
    <name>A0A2T6ZFR1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1103514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000307">
        <property type="protein sequence ID" value="PUU74309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFR1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFR1"/>
    <dbReference type="OrthoDB" id="4818801at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050278">
        <property type="term" value="F:sedoheptulose-bisphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046390">
        <property type="term" value="P:ribose phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF15">
        <property type="entry name" value="SEDOHEPTULOSE 1,7-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU74309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="210" mass="23384" checksum="DC2A98B023397B29" modified="2018-07-18" version="1">MSKLTPRVFIIRHATGEALIGEEKLICTSLLAHIYVSPRLRAKRTLELLGLFEKCPRLCEQSAETDQLVEWDYGDYEGLTSPEIREHRRTNGLVGDRPWDIWRDGCVGGESPEDVERRCDALIKTIREQWHGPAMHDGNVPGDVVCVAHGHLLRAFAMRWVGKSISNSTVPLILEAGGVGILSYEHHSIDKPAILLGGSFVVKAENHKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFW6</accession>
    <name>A0A2T6ZFW6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1092989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000303">
        <property type="protein sequence ID" value="PUU74390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFW6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFW6"/>
    <dbReference type="OrthoDB" id="2748312at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015537283" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="33871" checksum="5AF3A1BC454FA634" modified="2018-07-18" version="1">MKNLAQLYILAALTVAPSLAADYTPHVPSDTDFQPMSDPKPKFESFYPGIVPTTEASRLVKRLGRCASANSLLCPNTDKCCPIGYNCVGDGVNTGCCPIGRICDPSVSYCPAGQTDCTNIIGVSGCCPTATHKCSNSGGTPGCERLGSSGGSSGSSTSVCDPGTYMCADGGCCPNGSTCVSGTALCRKPCESGWTQCSFGGCCDPGYSCDASTELCRRTGGLSISISMPAPTTSKAPTTSKAATSGTTLINPFTTISIRPTTTIADSEPTTPSETEKGNSSSSTESVETGPRPSTTVPRPSTAALPNSSNALKPGGCLGGFGIVFFFVLFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFX1</accession>
    <name>A0A2T6ZFX1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1056290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000302">
        <property type="protein sequence ID" value="PUU74401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFX1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFX1"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="330" mass="37354" checksum="835FD51D6C10A877" modified="2018-07-18" version="1">MTINTTEAPKDRKIPKISVANFAERKAEISRQILDAAENSGFFILENQESPSVAEIEEMFTISERFFNLPEAKKKETPHIKAENTGWETRSQIRPSTGLPDQKESIQLQFHRRGDRSWPQDPSIPEFNKTVSSFMAKTHSLSMDILSIFAVALGFPEDFFAKAHDVNRTNAQSTMRLLHYHDITGTQFPPSYWRAGPHTDYDCMTMLFQKTGEDGLEICPGREAHTSFGMGDHWTPVKAKTGEIVCNIGDMLMAWSDDRFKSLFHRVRCPSVGERQTSRYSIAYFNQANKDVEIKGPLGKYPVMTAEKYLQDAIKRNYGGPTAMNALTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZG25</accession>
    <name>A0A2T6ZG25_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1000690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000302">
        <property type="protein sequence ID" value="PUU74406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZG25"/>
    <dbReference type="STRING" id="42251.A0A2T6ZG25"/>
    <dbReference type="OrthoDB" id="3902588at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="75576" checksum="0B90134B130F8619" modified="2018-07-18" version="1">MAHLVYKKPLQSQAYREDYKVLRKAKDTGLIDPESYKTAKKNLLAEVEDSNDADSRLTSSQNSLRRTPTNSTTSRPPSVSTSASSDSFKERERTRKGSIFERNDPNRLVFKPEHRSEEDREAAKKERKLRKALEAGRAARAGSFGHISSPGLESPSLDANPRASRTLSVSSSSGSSNRSLGRGLGIGFRFFGRKAPPVGTEAVRVVGKEDEEQQQNEEGEEDDGLPSHRRRAGSLGTIASGGSGLSSERGHAAGLGTGGDQSYLKTVADYVLVPKPPAKPAKSPHSSRSGTVSRRHSFGSQGERPSFSSSVRPDSSASRPTRRDGGIIFAEDGRLRFRSEVPREPEEVPKRPLSASLLNLFTQFLVTFSNTSRLFTYAKYGTVRRGSISINSVSAIDYDAEDSETDDFFVNSDESFVHLRSTMERRAWFLSAMKWLSFERVLFSPGHHLMVLNNGGTILDLDSGGIASNIHTVLLPTSPRPPPTTTHPPNLTFITTPTLTSLATIPSASVDIIVSHSLPRIFLTPATSTPHDQQVLLILHELHRILKPSGYLELTIIDPLLNNMGPLTTAYIANRILPAPTVHGVIKPLKSILKALKSMGPTERGQWAEVKTCDMWMPTTSIGDELSTVTSRVGRFLYDELYAPGEEAGVLAEGVVEVKDGGMWTDAGIVEECGRENTAFKWAKCYARKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGA8</accession>
    <name>A0A2T6ZGA8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1092531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000293">
        <property type="protein sequence ID" value="PUU74530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGA8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015612635" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11757" checksum="268F522E2D318380" modified="2018-07-18" version="1">MGCSGCLWILLDKLAVLFFPLPSFLFSFELRTGKKGHSSNNYSHANRLCSPHFSAFRSPKVQKRRQEKENKEGENGPKKNKNRNPYSEQRKEGGKGKGTRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHY5</accession>
    <name>A0A2T6ZHY5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1067671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000250">
        <property type="protein sequence ID" value="PUU75108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHY5"/>
    <dbReference type="OrthoDB" id="4768051at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="479" mass="52978" checksum="0360596B8F0F5936" modified="2018-07-18" version="1">MNITGRFSVSIVGLTYNLVDDSVVDYPTLATTWAPSVLLAKNATDFDLVEKSLLSYLDLNMDLETLHSFLIGHWFDGETGGMVNLKYYLLDFSTEKNQEIYGTSSDHAVHSSANCTMLRLEGHKYWRDYNSDDQISYGMLYEPLRWILLEAITKLTPILETDWKDESNGDTIAEVLRVLESKNAWPRQGTGQVTWAAPFVGESNGSSVTYVVYHDTAWECTSRFFETLEPGRGPHPKPLFDSATLFLLPIVERIERGVSEPTGGLVNSCGGPAVGRTASIAYRSFADLKSRSSPSIGVQTLNFYQNGTGGSAAQKMYYNIYVAGLVARLPMATIAYGDQIYPHVPKDRNANLTINVETTLKVKWGRVGIAAGIIVGSQILAIAVVLYYCRNVYVREDSYLTTAELLNTALNKIDHGSTMTMEELGDALGKALEGPVSYGTIPSGQGDQPSVALGREVDYNFPGFPPFRKRSVFQRRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ16</accession>
    <name>A0A2T6ZJ16_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1067399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ16"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ16"/>
    <dbReference type="OrthoDB" id="5284712at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="9"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="276" mass="29513" checksum="D8BD23D95041F49A" modified="2018-07-18" version="1">MVNTAILAKGNLALHIVQAVWSVVVMGVVIASLSANGPASGAAKFMFAMAPRFERTKMFAHPYWVIGVNTIFSILWFAAFVSVASYTNGGISDGEKKEKDEKIKKEGGCALFPAGTGEDPKACKLNQAAVGLGVIMWFLWLGTTAIAGYAAWYFRQHSVSPFEDITPTGHDIEETTKDAFSSNDEYALINKDRDEDDGDSRFSSHHGRSGSVTSYDTGYDAHPGNPVPWGGEGSAYNGIGGHGPVAMGGNKRTPSGLSMPIAPDEEDYSYRGASTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJB6</accession>
    <name>A0A2T6ZJB6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SNF2 family N-terminal domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_1116374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000225">
        <property type="protein sequence ID" value="PUU75577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJB6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJB6"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="334"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="678"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="887"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="772"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="772"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="834"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU75577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117506" checksum="9E53CA0C2EA60313" modified="2018-07-18" version="1">MARSLHAELNSPRVSNGMNFNNAVGGSDQGLPSISSGLPGMRQSNSDAGYPGRNSHPRRHEGYLPPRPMLQHAGSGNGASSSYPNEYDNGYSYSDSGYFDNTMPLSPASFGGLPKPSSASMFSLSHLPYDPTLPPNGRHTLPPLRFPPANEVIELPDSDEESEAGISQSSLGSILSGQDSRAGSARPFEFQNYDNLARADDGWNDNSNGFDDSMIPPNDNSNQMSQTPDDPTTASSSNNNQASQAPDSSAYGGIVDRDGNPLNGGWPTTYRPEIGNYINHIRNDPTKTLDQLKTLMENIRPDMEIPPENREGTPDDMTYPLMEHQKLGLAWLKGMEDGSNKGGILADDMGLGKTIQALALIVSRKSKDPDRKTTLIVAPIALLKQWEREIEKKLKPQHRLKVVIHHGNQKRCKSFAGFRDYDVVLTTFGTIGTEYKKKQALSESGDSEAINRANFFFVGDHCQWYRVIIDEAQCIKNKDTQSAKGCCALSAKFRLCLSGTPMQNSCDEMFSLLRFLRIEPYNSWPEFSNTFSRPLKSKSEHTVSNALLKLQALMKAILLRRTKDSTIDGKPILTLPNKTIEMVHAVLSPDEQQFYQALQDKSKILYNRYLRAGTVGRNYSNILVLLLRLRQACCHPHLIRDIEIADAKKPFDDEMIELAKSLSPEAVARLKDPDAFECPICLDAADNPSIVIPCGHQFCSECLLQLHAQHAEAAIASGNEEGGGARCPGCRGTLQPKKVIDLRTFRKVHLSEGEEAAASEEPEEEYDDLIYDTDSSEDSDDDDDTGSDLEDFVVSDDYDEEEEEEAVDSEEQGESSATASASENGDQAPARKAALPKKKKDLKGKGKAKEKRRPRTLAEVRKDAMRNAKSKRQYMKHLQKRWISSAKVDKCMEILQTVRDNDGAEKTIVFSQFTSLLDLIEIPIHQKGWTYRRYDGGMTSTARNEALTEFTDDPSVNIILVSLKAGNSGLNLVAASQVIILDPFYNPFIENQAIDRAYRIGQQREVLVHKLIVPGTVEDRVLALQEEKRKLIEGALDENASKGIGRLSSKDLGFLFGIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJF6</accession>
    <name>A0A2T6ZJF6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1131039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000223">
        <property type="protein sequence ID" value="PUU75586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJF6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJF6"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="107" mass="11944" checksum="D7B755E11DA42B5F" modified="2018-07-18" version="1">MNGNHTVIIKNGLPEKESLAMKESPKEHIKRNSWAKGSPPLRLRSLIKAKKHNLPRRLTGGLRTILIPGAASCESHRSLNFVWHSSLSSSIVDTSVSLLYTGHFHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKI7</accession>
    <name>A0A2T6ZKI7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1089262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKI7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="10286" checksum="C6E82276985B66EB" modified="2018-07-18" version="1">MDGWIAARSGLLVRFPWFIFFFILNSLALFGRSEHFLFCLFLGGCFFPSNCSLQWILPFFCVVDWCFFLCFFWCYGTGILSPSLPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKT0</accession>
    <name>A0A2T6ZKT0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1088954</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKT0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKT0"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000005">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="218"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU76083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="590" mass="66508" checksum="9C73C61664D79104" modified="2018-07-18" version="1">MGNFKKEASRRKREKPVDDGMANVKLKGENFYRDAKKVTRLNTLKQGKPIRNRNGDIIKAASFQSREVPSARIEPNRKWFGNTRVISQSALTSFREAMAVKAVDPYQVLLKSNKLPMSLLRDETEEAGKKVHRAKVHVESQPFAETFGPKAQRKRVKLQVAGLEELVGESELLEVKYKEKLETELLLSGKSSEEKEEDGWIQEAREPIFSKGQSKRIWNELYKVIDSSDVVIHVLDARDPLGTRCRSVEKYIKEEAPHKHLIFVLNKCDLVPTSVAASWVRRLSKDYPTLAFHASINNSFGKGSLIQLLRQFSALHSDRKQISVGLIGYPNTGKSSVINTLRKKKVCTVAPIPGETKVWQYITLMRRIFLIDCPGIVPPSATDSETDILLRGVVRVENVSNPEQYIPAVLEKCKRQHVERTYEVKGWTDSISFLEMLARKGGRLLKGGEADMDGVAKMVLNDFMRGKLPWFTAPPKDEEGEDSNVGVDLAGREGRLGEMRKKRTASDMENTADGDEEQEDDKEEEEWGGIQDSEDGDDEDDDDEEVSSDGGATLVPGQDTEDESEPEEEVEEPRAEVKPQANSQKRRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL94</accession>
    <name>A0A2T6ZL94_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_991099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL94"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL94"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="311"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="632" mass="70379" checksum="07F7E56CBA8F9DB5" modified="2018-07-18" version="1">METCDIIIIGAGPTGSVLSAILSRSTPRTITLERDTQITTDPRGIALDEDGIRLLQGVGLYKETFAEIGEGMGYFNFIPGKNDLSVPPFLRFNLATIEGGTGHVGFLCHKQPVLEGCLRRVVEQSDKSEIRGGCRLAGIDEIADGVIATYVRDGREHKLKGKFLVGADGKTGFTRKMYLEVKGVKLESSDKFRYNAVWVALNWHILLPTPETHPDFPLWKLGFTPQEVYDAFFPVHFRFICNPDRPSVCGRFGLSKDRLWRFEFIVKEGEDGVKMAEWKNVWKIVGPYLKHGGKRYGLDGDVCFPQDCIKVLRSRPFSFAARSCNKWSVGRVILCGDAAHVFPPFGGQGIASGFRDASSLAWRLNLACRSASTFNHETLFEGWYSERKQQLEKSLAATIQNGNLCNEPSKIKAFIRNTYFSLIRLWPAWAHQLELGPRAEGMVRYSWTKGMPFLPLLGGGGCIPQVWSAPLAEGAGKGDIFTDDAIFRMGKKGLFQVVVLLDSIDDVEDAMMGLAGLDEASSGEVLAEEATFIIHDTSLSDPAARHTIPRDMARNEGIVRIVSAEEAKVCNDSEKVPTWPEPLYYNCYRLQEEYAGKRYLIVRPDRFAFAACEGRDELMEAAGMIGKVLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLD0</accession>
    <name>A0A2T6ZLD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_991098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLD0"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="526" mass="57760" checksum="89EC2DAC0C588D53" modified="2018-07-18" version="1">MAKFLGLRGERLGFAVSFICTTGFLLFGYDQGVMSGIITSPEFNSTIPETKDNSTMQGFVTAIYEIGCLFGAVVVLFTGEALGRRKAIISGASIMILGVIIQVTAYAGHQPLAQFAIGRIVTGIGNGMNTSSIPTYQAECAKTKNRGLLICIAGGSIAFGTLISYWLNYGVSYTKSDIVWRLPISFQVIFALVIIASMTVLPESPRWLLSKDRDEEGTFVIAALNGEAIDSPKTQLEKRVILDSMMAAGEIGSKSSFRDLLTNGKTQHLRRVILGASSQLMQQIGGCNAVIYYFPILFESSIGQSRNMSLIMGGVNMVIYAIFATTSWFIIERAGRRKLFLWGTVGQMSAIPSGMAITFICLIPGTQAAAKGAAVGLFLYIASFGATWLPLPWLYPAEVNPLRTRGKANAVSTITNWLFNFVVVMITPVMIDRIGWGTYLFFAVVNACFLPFIYFFYPETRLRSLEEIDFIFAKGYEEKISYVKAAKELPLLSPEEIEEYAIHHGFAYASGPEKPTDLFVERRKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMR0</accession>
    <name>A0A2T6ZMR0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Necrosis inducing protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1051440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000177">
        <property type="protein sequence ID" value="PUU76763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMR0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMR0"/>
    <dbReference type="OrthoDB" id="10255963at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015618183" description="Necrosis inducing protein-domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="31078" checksum="9BD20D1B6710761F" modified="2018-07-18" version="1">MRIAAFAAIGLAVLPRASANNPLDDSFVQKDMSSNGGLEVAFASRPMWHFGKSKGNNPCYPSAALINGNQHGTNPDKFPHAGTGCEDPGPAGGMGNPFPTYFTVNFCGGDELRVTYNLYFSHDGFSDGVIAKGHMHDWERIIVIWRRENNQWFRKELLKSFHTGYMHDNWDAVQNTIDYSNPDEQDGKNKEGAKIYVGWGKHAMFAQRNTGWNDEASQGCGREFRSRDWWYIPTKSDLINTAPGSSAGNEMSTKDWGSADHGPWVVAPMVCDAKEGGFIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZMS8</accession>
    <name>A0A2T6ZMS8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1194475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000175">
        <property type="protein sequence ID" value="PUU76792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZMS8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZMS8"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="396" mass="43780" checksum="83AD5739A6B71756" modified="2018-07-18" version="1">MPMPTMPAKFTLQAGGYPAPPDSSQTQKAEGQVDSEEICSDSSQTQESEGPVDSGEIPPDSSQLGEAERPVDSDESSSDSSQTQESAGALDNQYYLTEGLDCVEHIKYIDISSFKGAVNTRVGEFCVADNNESSSPSPYLIFSPVTLHQLARIDSERKIKYKTVRTLYLTELETLIIKIMPLPEHEITTHVFERMIIDKVLEGGQRAMIIPAGSTRFPGLNNSNEAAASLRPCHVRPRYTDWPSVVLETGVSETAERLHVDGRWWFANSGGAVKIVLLFFVNLKASSIKIELWKEGTVRNQQQTRVRSAVTSTGPTLQKTVNLTPNAITGAPIKLRFHDIFLRNPRKELGEPKHYHITEDDLSEYYKSVWPPSLDIISPAEPYCAGSASSDGYIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN58</accession>
    <name>A0A2T6ZN58_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1129014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN58"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN58"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015481289" evidence="1">
        <location>
            <begin position="24"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="44"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="372" mass="40718" checksum="B12A20700F356716" modified="2018-07-18" version="1">MTTLWTCLLLIALGFIGVPVANADCECGYSLNSTVFTELVESDFTLSGNITENTDWVVQEWEVSKEASKGPYGRNAQAKNVVSNPSVQHNVSAQGVNGDPAGLELFVRRPDDNQDYIGVAEVDSRRTDMIYGTFRAGIKTTGVNGTCGAFFWYLNDTQEIDMEFLSSQITANSSPINLVLHSLLTEERGGDAKNTPTFKVVSLPFAADEGFHEYRFDWQPDKVSFYVDGIWLADMTNSQYIPQSPGKIILSHWSNGNPLWSGGPPEVDAKMTVSYVQGYFNSSLPSRHEDYQKRCKGRQGSLSICPIPDQKGAPKVGAVHFFSQQAGGDKTPNQTVYDKHLLKSLGSGLTAGRDSWVLVCSVLLASVMSLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN76</accession>
    <name>A0A2T6ZN76_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heme peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1128940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN76"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN76"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1136" mass="128397" checksum="41DBDA8DB322DC70" modified="2018-07-18" version="1">MASHSNGTDGATNGHSNGYSNGASNGVSKGKTAKYATRAKPPPPVAKPTRAAVDSTFEQFANLLHASNRPLPNRFGDGQDRRPPEVKQTGVLTDIKTLRSGGFFWESVGTLWTLLKQKKKGGPVDDKTMIMERVIQLTSRLPPTSKVRVLLTTTQVGQLWDSLQHPPLSYLGDEFSYRQADGGCNNIMYPQLGRAGSTYARSVKPMTKMPGAPPDAYTLFDSIFSRGPNDEHYREHDNNVSSMLFYTASIIIHDLFRTNRANPNISDTSSYLDLSPLYGNSIEDQSKIRTFQDGKIKPDSYCEKRLLAFPPGVSVLLVMFGRFHNYVVENLKAINEGGRFNLKFPRYPNGDDEATRQANALRRQDEDLFQTGRLVTCGLYINFVLNDYLRTIVNLNRVDTTWTLDPRFEASKVYNPDGTPAGIGNMVSAEFNLVYRWHSCISKRDDQWTKDFYQGLFPGRDTRDIEMPEFLRGVGRWEASLSDDPVERNIAGLDRKADGSYHDDDLVKILTESIEDVAGAFGARNVPHVLRLVEVLGIEQSRKWQVASLNEFREFFGLKPHATFEDINPDPAVANTLRQLYDHPDFVEMYAGLVAEADKKPMVPGVGIGPTYTISRAILSDAVTLVRGDRFYTVDYTATHLTNWGLQEASSDPAIVHGCVGYKLILKAFPNHFKYNSIYAHYPLTIPEENHKIHTALNTVDQFDFERPVYTPLRIPISSYSATKQILCDAESFKVTWGAGFDYIMRADFMLSGDKPSNTEQKQFVRQRLYLGDVDWRQQIRQFYEECTERLIRKKAYRLGDAYQVDAVRDIGNIAQTMFAASIFNLPMKSEDHPKGIYTEQELYTILCVMFIIIFFDIDSSKSFPLRQAGFKVVRQYGSLVEAQVKAIKNWSWLQGVWDPLNIRGRNKSSPLKSYGWTMIKRLLESGKSPYDVTWSYIVPTAGASAPNQGQIFAQVLDFYLEDRNAHHLAEIQRLAHLGTDDAWETIKKYALEGGRLAGTFGLYRRVEPDNITIEDNGRNIDLRSGDMVFVNFITASRDPVVFPDPLEVKLDRPEASYMQYGDGPHECLGKAANIIGLTTMLMQFGKLKGLRRAPGPQGELKYIPKPGGFKVYMKEDWSAYWPFPTTMKVRFDDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZP38</accession>
    <name>A0A2T6ZP38_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1128511</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000157">
        <property type="protein sequence ID" value="PUU77251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZP38"/>
    <dbReference type="STRING" id="42251.A0A2T6ZP38"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043436">
        <property type="term" value="P:oxoacid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="5">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="5">
        <location>
            <begin position="146"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU77251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="217" mass="24017" checksum="73CD0864C9063394" modified="2018-07-18" version="1">MHLVCDLPQGRISGSQHTEFYPRISSQFKSPTHFSLIQSYVDTSSSLSTLQNLTKKIVQRHSKIEEVAKRMGVDLCGAGRGIGHQILVEEGYTWPVTLTVARDSHSNIGDLGHLANMAGDSSSSLDGGQRCSTKGGYWKGCNYVNLSLCGHFNNDEVRNHAIEFAGSEQTLEWLKIDDSLTIANMTTKWGALRGVFPIDNELKDWMLQKAFHSCPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPD0</accession>
    <name>A0A2T6ZPD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Actin family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1101910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPD0"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="388" mass="43884" checksum="0C64618B89A876A8" modified="2018-07-18" version="1">MNEAPIVLDGGTGFLKVGYAGQNFPEHQYPSIVGRPILRAEERAGDMVVKDIMVGDDAAAVRTMLQITYPMDNGIIKRWEDMQHVWDYTFAEKLQIDTTSRKILLTEPPMNPLSNREKMCEVMFERYNFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTRRLNVAGRDVTRQLISLLLRRGYAFNRTADFETVRQIKEKLCYVSYDLELDHKLAEETTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVEQPGIAEFLFNTIQAADVDVRTSLYKAIVLSGGSSMYPGLPSRLEKELKQLWLTKVLHGDPTRLSKFKVRIEDPPRRRHMVFLGGAVLANIMADKENMWITKAEWEEQGPRVIEKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPS0</accession>
    <name>A0A2T6ZPS0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1065826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000152">
        <property type="protein sequence ID" value="PUU77475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPS0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="112" mass="12487" checksum="5D7777977D1DCA24" modified="2018-07-18" version="1">MTPEDSITLRDKVYSAAKLAANMHKLLTSQDPPIAETGRALGLIKSVVDEVWDTLHLNLLEKGERWICLEEANEIIDSRMRILVELGEEIREVVAGREGGYIEGASGREEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPY6</accession>
    <name>A0A2T6ZPY6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1086036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000149">
        <property type="protein sequence ID" value="PUU77558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPY6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="123" mass="13116" checksum="6A8C0270AD4836B1" modified="2018-07-18" version="1">MSARLSNRARSQCRAALINSLEPSAAGDGTSIKRIASSLLPRTRLTVSTATDIKLPFSTTIIRTSPSFPSSSRAPNPGSASSSPRLHQTYDTVPRATPSEADRLGANPTSHPLTRDYLRSLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ17</accession>
    <name>A0A2T6ZQ17_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_986379</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ17"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQ17"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="574"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="779"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="813"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1156"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU77575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1226" mass="134503" checksum="3DF47715D2927298" modified="2018-07-18" version="1">MTGRTNSTPNHRLAAIHGVDDRNERYFPLCTSVSPGYARSSPPLSNSFSNSLPGPATPYHREMTIRAVSPDIGLEEEGRDRDSDDSLTAQHSPTTPPRTPSRSSNKSASMFDTLGRDPTEPSTPSSPGKARALLNRTPLSGFPQFTDLGIGKGKSGSPADERKKRASPSSERPGTTDTMYSSGSSSHGSRYRNFASGSSHESSDSIPTSVGFPSTTTLSPINTKPSSKSSRQRFLRPQNSVNALNSGVKASDAHFASPPATPADTNTILRLMKDVRGRMEGHVEFRVGDATIWTKGYCLINEDTGSLVHQKEENINSTPLTVIIPDLRSCKVKSIAPTDEGSDGIIDVSTHSTNISIKLRPLDPNHFMPWLAALLCWQPIAPAGAQNKMVKPQAFVLAQERKADRRRNSDATSSKDAAIIKVGKMLKWRRGGPTAVTTASSISGKGSSKMKGHTGGVAWQKVSCTLQENGEFRLYAELDTTLLTVIQLSQLSRCAVQQLDPSILDKEFCIAIYPQYTPSSNVSLARPVYLGIDSRILFEVWFVLLRAFTMPELYGPAGTAPSSDGRSAPGVAAGMSEYPAAEGLVDSYRIQRSLFLRVVEAKILMPGAEYGGKDNMDCYAEVVLDGEVRAKTMVRTKTHNPFWREDYEFPDLPAILSDVGIVLKQRHPRWKTKGSGSVTGSGGFGGGLGGVSVPGSKDAIIGTVEIQFDELKLETDTERWWPLMSAAKGAEERIGEMFLKIGMEELIVLMAHEYRELSELLHNFSGGITMEIAQVVGPDLRRLANTLLKIYQVSGKASEWLMSLAEGEIDGLHKESPPVRLGRHRDSNESNSDPDQSRRDVGKAGLVDANILFRGNSLLTKALDAHMKRLGREYLEETLGEQLREIAEDDTYCEVDPLRIEPGENLAKNWKILMGIVKGIWKGIYNSHEKCPMELRKILRHIRACVEDRYGDLLKKVCYSSVCGFLFLRFFCPAILNPKLFGLLKDHPGVRAQRTLTLVAKSLQGLANMSTFGVKEPWMEPMNVFLGEHSTEMRSFVDAITTIPPSPYPTETVPPSYATPITILSRLSQPSKEGFPSLPYLIDQPRAFASLVAMWQKWHPVYKDKFPDYHLDGDLARFHKMCSETQERINICVSKAESAQRPSSSLSARWEEVAEKATGSPLLGPGQTSISTIPGKGLRVVGLPSTRGPEEDYHHSGATRSKLSGFVGGFRKKVKNRGTFAGSEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQF1</accession>
    <name>A0A2T6ZQF1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1108701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5427617at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1338"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="956"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1357" mass="148223" checksum="DC60F04ED16FE857" modified="2018-07-18" version="1">MPSPRKDGEKSPLALPMSEGQEKHDSSGTLGTLSISGNTTAPNHRIGESETLPVTDVHQDVDHMHRVPSIATHDGTTEARTTHQESLPSDSTGLWRGGSESFPHSDTHQDVDHMDHVPNIATHDGTAEARTTHQESLPSDSTGLWRGVSESFPHSDAHQDVDHMDHVPNIATHDGTVEARTTHQESLPSDSTGLGRGVSESFPHSDAHQDVDHMHRVPDIATHDGTVEARTTHQESLPSDSTGLWRGGSESFPHSDTHQDVDHMDHVPNIATHDGTAEARTTHQESLPSDSTGLWRGVSESFPHSDTHQDVDHMDHVPNIATHDGTTETRTTHQESLPSDSTGLWRGGSESFPHSDTHQDVDHMHLVPNIATHDGTTEARTTHQESLPSDSTGFWRGGSESFPHSGTHQDVDHMHHVPNIATHDGTTEARTTHQESLPSDSTGLWRGVSESFPHSDTHQDVDHMHRVPDIATHDGTVEARTTHQESLPSDSTGLGRGGSESFPHPNSGGLGPSPSVEHGPRVDVLVLGPDPRRAEKPVSERSPAVTDSEKKVFLTLTSPSASRGTSSAKQRRTNDSRSNEVEHRYQEPPSNAKYRQRSPLRTTNHRRRHSPHRRASSPSRPPRSPYHRAPSPRGGDQYRPSSHHNLHNRHGDDDRRPRDHNAGRSGRGPRSPTRAQSSSFREGTFSGRISRRRSLSPARSPPNWDRHPRTSHHHPRHHSTSREPRSRRSPSPKRSRDISRRSPSPKRSRDISRRSLSPKRSRDISRRSPSPKRSRDVSRRSPRQGAPDPRKPLGGGPPKERAHQRHNRRDSEGGRATSSAQDGSIGCKPGPKDSTQGDHASTNASKTTRGCMEGTRDDGKIGDKPRASTRPDLGPTSEPFEATIPSPKSVLLNPIKSTPTAPGTNVSPSTNTRRTSTIAPETMGNLKSFADKTPGGLPGGPTPLSGTLPDSIPQDSAAPSKAASPLLSQEIPKLPPHPDVSPEFDAEYLKDRELARKMLGVSGKEFDAEMARRTADFNADIARRIALGHPIHGKNLPGDNSKIGESSRDADKMDTTSDDFTSPKASTQVGSDHATQPGLEGLIPQTPEPKVDAIWNSNETPENYNPYDEFVFTEDNRWPGADELDKLDSFTSFSPRWRSNSPSFVAGAPLYHIPKGFFGSSPEPFIPASPPPFGPKKPARKPKSVDRGTSPDLAINCAACSPPLTISLTGSQAALYNVHLKDSDDTSHLLFTNVPKNYYLLHVLTFPSKISRLIHSDKIITLRDFTKVIRLGFNLHRPISQITVYLYGRDSDGCPLEWKPIHIMSVTDWDGSMSVGRQWSCQISVVVEFVEPDADTAVSAAAGSGPESRAGGAGPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQI7</accession>
    <name>A0A2T6ZQI7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_141782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQI7"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="181" mass="19464" checksum="4FE3A778789D3608" modified="2018-07-18" version="1">MMGIPIQGSSVVRYRTISGKSSRDSLIQQGRIWAKVQIKISTLGSPKSPTFPHKKLNTRSKTYARVIIHSATVITAHGPNAQLSTGTCLHWQPTSRLPPSPLSPPPHAANIVVLLRIQALPHNPLPTAIVDPIGLLRAAPPPSPPTMARYIESLAGKKEKKKCQGIGVPGMVTALTFQPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQM0</accession>
    <name>A0A2T6ZQM0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1108678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000141">
        <property type="protein sequence ID" value="PUU77785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQM0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQM0"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="204" mass="21457" checksum="C81E02C900E6F3F3" modified="2018-07-18" version="1">MSGGFRIASTEDTGEIQDTENDLPVLTFSLPTTGEGKPLGIRSGTYLARPTTPVGTARAEPGSSTPFSAPNKGSNSTILPEPAGDSTVPAVPTRASTLLSVPPTNRTILPVLSSHCTVLPSPSSDSTVPPSPSSDSTFLPVLVSVFTRIWEFQIPLENIFANDQPKVLDPKDSIIFSLRELEAHVIGSPQGTTKPPRLLGDLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQP7</accession>
    <name>A0A2T6ZQP7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER transporter 6TM N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_985502</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000139">
        <property type="protein sequence ID" value="PUU77803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQP7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQP7"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="7">
        <location>
            <begin position="109"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="8">
        <location>
            <begin position="567"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="6">
        <location>
            <begin position="706"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="944" mass="103795" checksum="958EC9CBCCAB2502" modified="2018-07-18" version="1">MASPKKSSLSGLWGKLGLDAPTLMLMGKGALPPAIFTAAYQATPVAKTYTTLGYLATIIAALSLCILPRAKLVQLTIQNSIAVALAAATSLLGVWTATRARAHYASPPGQIYSAPASAVSATWLFVNIWLANLLRAKIPSLAIPVIMYTIFVAIMYTYGGLYTMPRLIATAVLLLKCFYTGFGLAFAVGMVVFPMNCREIWWKIFTGYLLTSKKLLVEQKNFLRQHETMGTEEGEKSSIALAALEKAHADLFTKLSTELSMAKREIALGRYLTSDLQEAYHLIRATLRPLQGMTVILDIFDRAARAGLEQDEKCPVPREEQLSEVMKTLHEPYERIVGMCGEAIEHVLLTMKLKPSPKKPGGDEEAPSIEPGAQGFCQSLEEEVQEFYSTRAGDVRTYFSSSKTTKTSDSAGGISAEVYMDEKRRSELYLVLFMEYLLYNAAKSLLALARFAEEKKQQGVVDRTILVYPTSKRLKKWLYSMASSRNDDVVDVCDVGAVRVSGLDGIAPKKDPEHLPAGTFLQRLGELVAIFTEGISSSESGFGLRVACATLAVALPAYFESSYAFFIEKRLVWALIVIAIGMSPTSGASLIGFVGRIAGTAIATVLALINWYIVDGIAGGVIPFLWFFLAVQFYFVIKYPTLIQSTLTALVTHIIIICYELQIRKIGDEVSTRTGQTILSVNEIGPHRLVVTIGGLCVAMIFTILPYPTTTRSLIRSSVSSSLFLLARAYSVTFSLLHLRIHGAAGDESNKYSPGRRYEKVRVKLLTESFLANDFLRTQIDFTQYEPSLRGRFPKEQYDGIINGVRNITNYLSIISYASKTFPAGGEWAEDFSALLRNVDTQMHQITSLLCLLSASLASGNPLPPVLRLPEPFRLVRAMEERDGGLKLDHLVEPGFMAFAVVQVAIGVMRDDLVRIIGMVEELVGKVVFPDERSFSGDLKAKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQY2</accession>
    <name>A0A2T6ZQY2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_985110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000136">
        <property type="protein sequence ID" value="PUU77898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQY2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQY2"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06601">
        <property type="entry name" value="GH31_lyase_GLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF120">
        <property type="entry name" value="HETEROGLYCAN GLUCOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="339"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="775"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="951"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1064" mass="120611" checksum="9F408574A37337D1" modified="2018-07-18" version="1">MDDPINFITAEEYYQRAQGWAGPARVTSLSQTPPTTASQPKYWRGVTLTFDDSTLCVVQFVRPTLFRVRYDPAVRNPEEYDDANSRTIIEDYMSQLVYDLDDFAGITCATELKESDDQKYWIFSSTVTEALEKEGKQQHYKVGDGMKLFIYKDPFRIQAVRVLTPLPDLYPIPGSPSTTSRAIEKVVWQTSPKTFRWNIHPVVSVVKQVVLDVIKAGHGEFIGFGEQGGTSFMKTPTFMNYFNFDNMQYQQVYSRGPLDAREPLYHSDPFYMDVNSNPEHANVTASFLDNYSQIAVDFGFTNSGFIRLGTRFNAMDIYVISANTVPEVTRLHTSIIGRPKLKPKYVLGHHQACYGYEKVEDLYAVVEQYRSVGIPLDGLHIDVDFQDGFRTFTTNPRTFPDPKGMFTKLRENGIKCSTNITPVISINDREGGYSTLREGLEKGYFIKDKRYIDGTSGKAEDVLYVCYGGGSKYTIDPKDVSIRPDFGDNYDFVANWNAKDYSYHGGVSYGYGNGTAGYYPDLNREEVREWWGKQYHYLYDMGLEFVWQDMTTPAIHTSYGDMKGLPSRLLMSSDAVSSAAPTEKTAAEIWALYSYNLHKATAHGLDTLEQSLPSRKNKRNFILGRGSFAGMYRYAGLWSGDNASTWEFWKITVSQVLSVGLNGVSVSGSDMGGFEPYFNPSTGQEEKYCNPELLIRWYAGSFLLPWFRNHYVKKTRKWFQEPYAYPKHLEQHPELEPEQGWLYRAVQGICKYYVELRYSLIQVLYDAMFDNQLNGLPIARSMLLTDTQDTSFFNESQRFLDDQYVVRKDILVAPIIKGSNENPGQNRDVYLPLMHLWYPSNLRPWDDQGVALGPPVDGGSVINYTARITNEYSGYPFVTPVYLREGAIIPQVGVRQWVGDLSSGPNRMKINVYPGRDNEYITYLDDGVSRSSAPDDLLHYQIIASVAVARKSPDSDSPDQEAKGEYRSVSISQVTTHPISTSSTRTVTIAPVHSNYNPVTELGEKYTIIIWYDSGVDVSRLNVSVDPVTGVQYDIFKNTTLRTVVIDVKETIGNSPKIVISVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRH5</accession>
    <name>A0A2T6ZRH5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1084787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRH5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="95" mass="10794" checksum="27E6A42B813AA68C" modified="2018-07-18" version="1">MSHVSHSSTGTVWVFGRIIPFFSFHSFFWLFLAFFFAVFLFCYHPVAFRRSLIACCCCSLMSSLSVWFNCVRCVRRLSVPVGGVAVVFACISCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRJ6</accession>
    <name>A0A2T6ZRJ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_984277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRJ6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRJ6"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="484" mass="55092" checksum="55DAB7B4DDBEA62D" modified="2018-07-18" version="1">MPIPILGEIYYNGIDSIPYLLPVLKVVPWLLIVVILKVYFNGYRNRNERVMHGKVAIITGGTSGVGAAIVNDLAARGTHLILLVRNASDIFTVDYIEDLRERHGNPFIYAEECDLSSLHSIRLFATKFIDNTPPRRLDMVVCCAGVMAPPYTPRTTTEDGIEAHWGLNFLANFQLLNILAPCLRAQPPDRDVRILLATCSSYITGNLDLNDPQFFRRKYPLRTPWLCYGASKMALMAFCLEFQRRLDSYVRPDKQPNNVRIYNIDPGLVRTPGSRRWITMGSLWGLGVYLVMWPIWWLVLKDPQQGAQSFLAAAMSPECGMGEGGKFLRECQNQKYRADELTSPELGKQLWELAELMIKDAEKAGAIKRAKEKGKKKAQEDMKSEPKPDEGDKELVEKIRQRKEALRKILEEEEAKEHEERAKAKLPPSLIPPPPADTPRRSTRSRTEELRAEEVKNVPKVKIETKEEVQDAPSRNTRRRTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRN0</accession>
    <name>A0A2T6ZRN0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_984155</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRN0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRN0"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU78149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="667" mass="74151" checksum="3DBCB5875FFAA1DD" modified="2018-07-18" version="1">MATNYFNITGVREGINGPAVPLRQEIRALQSTNPDMFNIYILGLQRMQSLPKTDRLSWFQIGGIHGRPYAAWDNVRGNGNASGYCTHSSILFLPWHRPYLALFEQSLFENVKAAVAAFPPGPTKDKFTRLVPSFRMPYWDWAADARIPDFVLKNETIEVETANGKQTIRNPLYSHSFGSIDRREFPERPYNTWLNTVRYPNTTNINPNDKGSPTQVAAGMQQQSSPSQGNFYNLRDRIYALLSRNNYQNFAYFSNDGWNNNGSADDYDSLESVHNTIHGTIGGGGHMSTPAYAGFDPIFWLHHTNVDRIFALWQVLNPDSYVVDQRAANSTFWSNANSTEGANTALVPFHQNNTTYWTSLTCRNLKNFGSTYPELVDWGVVGPTQVRTNVQRAVQTLYGRTAPVNRVLGQAPGAIGTSILSFSQPGVPVTVGGSGIPQTDGPGDEKTEGYVPTQSHYGQSEQQPIQSESTGLPDLIKDVSSGEIGQSLKEFMLISHFRYFCNIRVDKYDAGGSFNVHIFLGEFTDDPTQRAYDDNLVGTFSIFANDPETTGCEKCQNEAETGLTVTGSIPLTGALLDRIPLDRIPELSSLEPENVIPYLQSKLHWRCNKPDDTPIPREEITTLKVGVASVPVQVPTPDHLLPKYGEWRPQYEVTAGRKAGLAEGDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT86</accession>
    <name>A0A2T6ZT86_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_40380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT86"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30329" checksum="8698B2023DC49E8C" modified="2018-07-18" version="1">MKKWRRCAKGQTATSTMRPLMGNSHSQDKSCPAFLSLQAEHFESLEKKKCHPPLSGEKAIELPQLERPEGKRGILNQTNMDLLPFSCSFSSRQPTHLSMVRGTNRAAFAATRNIPEATRYAACFRHSFPFLLAFPSLPFLFFLSFFVFLVNHHHTPPHSLVVEVVCVGELSAWDQTSQTLPSYVPIIPVFQDTKHEGGNFSNSPPLVTLIIIVIVVIFGIHCLTGQGIQARIEGSRFPNVCVGERKREQKCCLDRLMSMMGYGTHNTNPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTG1</accession>
    <name>A0A2T6ZTG1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTG1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="124" mass="13857" checksum="3938728AC970D3DA" modified="2018-07-18" version="1">MGPGVTPSSTYTTIDHPVQDERNASTSESDNEPSEYQDTPPHNISPNTPEQTRSPTGTSTLSEISLTPSTEDMRQRTRSRREPTLQLNDIGELLQSHEEDIVNRVVTQINSQNLNRPRQTQANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU91</accession>
    <name>A0A2T6ZU91_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1064536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU91"/>
    <dbReference type="OrthoDB" id="4233498at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015549827" evidence="2">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="179" mass="19224" checksum="52C53DFF54277BA9" modified="2018-07-18" version="1">MFSLKNLIFQLLVLAIIAALTNCSPSDRLSGGVSRRSELATNNTAPTSTGSGSINILNQAQFEASGLTLITPGPVSDNPNGHVYCETSDASPSISNSRRLANWFYNFMGWYCCNWNVNGGGCSHMMTIEDASTAMCGNQGCIRCGDVMANLHRIVEFCQRDGKVGGVSFLDQGSHIVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUD0</accession>
    <name>A0A2T6ZUD0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1101024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUD0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUD0"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04129">
        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="190"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="375"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU79055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="703" mass="77659" checksum="3F45DF5D00DF2F01" modified="2018-07-18" version="1">MWRPGQWSTPAGNTPTNSPPPGALPHHQQNPLFNNRPYSPSPLPGGIGASGRRPQPTPRASSLSLGPGAGTSATGLSASLRSQHNISGGGGVGKRAVSGGPPPAGIRHPLDVLEEILGAQVKPLVEEEGDLDRNGGSWEPEVEDAEGIEFGEGGLEEFLKCEEVKEVRAREIKSRARAYSAHSVDEYEREKGKFQDLHRSIKACDEVLKSVESYLYSFQTDLGVVSAEIETLQNRSTMLNKRLENRRGVEKLLGPVVEDVALSPNVVKRIIDGDVNDIWVRSLQEVDSKMKAIAALDATKVKATKDVKPELERLEHKAIERVRDFFVTRIKAIRVPGANAQVIQQSGFLRYKALFQFMANHHVQLADEIGQAYINTMRWYYLSHFTRYHKSLEKLKLHVMDKHDVVGQEEPARRNNLISSLKSSAPPSYDAFNIGRRIDTLKNRTAPVLTASQAEEGRTAHYPEVPFRHFNAALTENASSEYSFITEFFSHKTYDQASAMFHQIFDPTFTLGQTFTKSLIDSTLDCLGVLLCVRLNQYSAFEMQKRRIPAADAYINATNMLLWPRFQIIMDAHCESLRRTSTSTSGRGGVSSVGGGLSAKQQGTAPHFLTQRFAGFMNGILTLSAEAGDDEPVANSLGRLRSDFEAFLTKLSAAITDAKKRERFLFNNYSLVLAVIGDTEGKMALEQKAHFEMLKKAFGSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUS4</accession>
    <name>A0A2T6ZUS4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1774-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1023977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000097">
        <property type="protein sequence ID" value="PUU79242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUS4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUS4"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33948" checksum="73948D337701F73B" modified="2018-07-18" version="1">MAFSNPFSRDVEGTRRNIPAYRALTIISWLLSFVAAIIYTITPPGHGHHGHWATGTIFGISKAHITPFTLDHVFVSIYWVVLFCNQISFIVQLFRRDEAAVTAAASVGSHFILFNLFQFCWIMLWTHSLFIWSELFAVLNFLQLVLLYLRNPTTPRQVIPSTLTCFDTNIHRLVHVPAAAMPLTWSFFLVLWNGSVMVGCHGLACRVLANIAIWGIAVFAGFFLVVFKDYHVGFATAFLAAGLGVSQFFVKIIALQWIFAFTIMAIVFLFSLAVAVPGIYGRETGVEARGGDRERAPLLREDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVG5</accession>
    <name>A0A2T6ZVG5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_979717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVG5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVG5"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="211" mass="23613" checksum="5655F9734F568661" modified="2018-07-18" version="1">MFTIRVGTDLQAFHIHKDLLAGLSDEMRYYVYDDPGEGQESTMEMEQVSPDTMRRFMEFCYSGDYLYTSDSEGSSDDPLKDKDAIEAPPLLLTHAKLYVFADMYNIVSLKELSANKIIALMPFLGKLEDRADALAMIALMDYVLNSILVTAGTSDKLVKFLARYAGCFIEELGGYPEFHTVLATSAGTDFFKVFCRRVKAGDGKAPWTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVI7</accession>
    <name>A0A2T6ZVI7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_979383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVI7"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="511" mass="58315" checksum="3220F09075ACECE9" modified="2018-07-18" version="1">MMPRGKASTTLDQTVIPQLSTGELRSIYSQELFVFRCDITAAQISSAMTSYPTLRDVGVLTPDDISNLSRQIHTKYRLSRSESEVFKHIEQLITDLRSGEIPGHPLASVHLMSCLKDMERFEVANEFWKWLIDQDETHCDARVYGVAIENYTYQGVTQGELEKMFMEALERYSETVDPKIARDTGKATRLMLLQGIITARILHGDWRGAYEGFDISVRLYPTLTPARIYELFLYERPVKEAYIVFLMACRAGTPPRPPTLTPLLKEIWAKHRDVKAMIRLVYAFVGAGGKPFPQHLNSLIFAILGSLPGDVSKNKGEEFDKMFGATMALIRDLISAFGRLQVFPSEGTFNTIISLGGKLQRLDLVHGGMKELLAAHLEPNMVTHRTIVNAFGEIGDREQFQAGWRGLCAARKEFKMPWDIKDFIALIKACHLPFSSYLRCMYVNYVKGRLKSQHARLRPWRDRSQQIRYVARNIPPIHSKDFQNAITNAQCFHRFPPHYICRRPVTPSKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVX2</accession>
    <name>A0A2T6ZVX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000086">
        <property type="protein sequence ID" value="PUU79623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVX2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="120" mass="13032" checksum="7C84ABD50BA8BBAB" modified="2018-07-18" version="1">MRQGDRNQATQDDTKRILGAVALGANAQSQSGGRTTPPGAMVDSSVITLLDVVSPESSLRRMGPQKTELMPHILQVTRSARKGTKILRRQQIRTIPQSHARSSTPNTKPNLHIRGVANES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWR9</accession>
    <name>A0A2T6ZWR9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWR9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWR9"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="235" mass="26264" checksum="6FC26C31D5C20D08" modified="2018-07-18" version="1">MLSFLANAPKRTHTAYLDPLPLGGHYTSSFPNPPKSPIITNRQLLPPYAGPHVSTFSEPPYHYHIRQYETFTVESGSLLATVDDEKSVVKTGESVTVKPGQYHTFRNASESEDVQVLIELPRLGGNAGMFEEKFVRNAFSYGLDCKRDGNVGETSPWQMLLFMWDADIFLAIPIKGVPKTIQKGISWIVMFVGGVIIGERLLGYKRTYPEYYSEPSEVEEPTKGEGDGVKVEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWT3</accession>
    <name>A0A2T6ZWT3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1124366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000077">
        <property type="protein sequence ID" value="PUU79942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWT3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWT3"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="630"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="697" mass="77372" checksum="6C8EDB7D17CC1C20" modified="2018-07-18" version="1">MRAPSPSRQCSFYPTTPYILSHYTSVYNPSPSSLTDSQKRQKLQEFNNGFIDYESSIDYPLPYNSVPQSSTRNIHLNPHINLQRAPGPASPTTLSTRSPPSPSRSRLPIMSTEQSPQDFQLYDDGSHISADHRQKQQVNRRYDSVHSFEHRASPTQNSRFGTGFPTTVPQSESHTSRPGLPYYSNFRPDNNDFSKPPAQQQHQYLQALPQFRNQGSNMVQMIQTQHHGSDDEDPPALSPHTQSQFSVSSRPSLSDVDLHSPATPIASPGPSDGADGCGAPVPAVSEDTSYLVEAWIEHYLRSESDIRTPAPKLGRTISDAFQDELFNPGIAPGTSITSQSMQDSNNMNSKLPKFLHQAQTQHSMARATPPTTRGHSPFRANSPFHPAAARTNQFQLPQSPSRTTSLLPVGFGTARAQREQEAEREAEILSQHIQQGFGPGSEAPKTISPKDAYVDYCEPEEEDVKGSLFPQDDAYSQDGSAHGGSYKGSIHSDDDVQSDHSFGIKTEESFGSMATSRRESDVSMNLNPQLYAGNGNQQYAQICFPYTYSASDPVSQASVAEEEHDYDYNPASSPNSKPAESRANGGVYTCTVPGCTKRFPTTTKMSKHRREAHRQSTPLSSIKSHHPGPHKCTRINPTTNKPCNTIFSRPYDLTRHEDTIHNTNRQKVRCEICNDEKTFSRQDALTRHKKVKHGIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZX32</accession>
    <name>A0A2T6ZX32_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromatin modification-related protein EAF7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1100482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000073">
        <property type="protein sequence ID" value="PUU80057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZX32"/>
    <dbReference type="STRING" id="42251.A0A2T6ZX32"/>
    <dbReference type="OrthoDB" id="5595141at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581">
        <property type="entry name" value="MRG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13581:SF5">
        <property type="entry name" value="MRG_MORF4L-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="336" mass="36076" checksum="E2002864954C1FCF" modified="2018-07-18" version="1">MPPKKKNKGRHAAADDDSPPVPEPISFDGWTDEQETTLFKAISVYRLKPAGVHKHFRIIGIAELMKNHGVSDTHTNIEGIWRKLQSQYNLEGLDEREDIEDDLDTPDPSGEFTLPADEYGALMFSRRSDPNSVDSPLTVVPQTFWATGMKGKKGGRAARSESVVSGVGTGTASVNPDDTEDESMRSVSPIPTKTRKNAAKAGTPSTSTTTTTASRRKPPVRKKGLVAKAKPSPKRKPLAKPASSEGESNTSNDELSDLPDDVDGDEDAGTVAETEAGEEEEPEAVAESEMGESTTAAGTPPSVPKKRGRKPGSKKVVPPPKKGAKKGDVRRSSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXK9</accession>
    <name>A0A2T6ZXK9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1172523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000069">
        <property type="protein sequence ID" value="PUU80247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXK9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXK9"/>
    <dbReference type="OrthoDB" id="586585at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="131" mass="14853" checksum="51735E7B32B7EFCE" modified="2018-07-18" version="1">MESVCMALIDVLDELVEAGKISHSLARRIIYNYNVSVQDNIGKCGVEIGMKAKIIDYRFVESVWWFNLKDIAISKGPLQRRAAGTEMVRFEGPLRVIAVGYDATAKTVKARIPGHNMFEPEDRQLWPGLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXU9</accession>
    <name>A0A2T6ZXU9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_975396</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXU9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXU9"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="14">
        <location>
            <begin position="80"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="15">
        <location>
            <begin position="221"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU80322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="389" mass="44588" checksum="E8AE244E2F093F30" modified="2018-07-18" version="1">MADIIPLTIRCHRAISRSNHILLPITLIHHMTHTTTGPTPPSPTTTITTRNYHQNNNHHNHNHHNHNPPPTKPTMANSKYEYTRNFETPHPLLLNTYIILRLDGRSFTNFTQTHNFQKPNDPRALHLMNASATATLRTLPDITVAFGVSDEFSFLLPRECALFDRREDKLISTVVSTFTGWYVFLWPKYFGGGEGEGEEEKPLLAPPSFDCRAVCYPSMGNVRDYFAWRQVDTHINNLYNTAFWALVLKGGLSRREADAELRGTFSADKNEILFSRFGINYNNEPEMYRKGSVVYRDYRTLEDEDEDATAKATATATAPAEPSTSTEPPERNEQREEEQQTTAVPKFKSKTQREKEKKRARKAKIVTEHVDIIGDEFWKERPWLLGSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYD5</accession>
    <name>A0A2T6ZYD5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_1079105</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase d subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYD5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYD5"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU80508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="123" mass="14117" checksum="86F3994650D79531" modified="2018-07-18" version="1">MEVDFSYYRSILKNQAVIDEVESARKRFQPVTYDVKKQIKIIEGFEAEAVKNAEATKGKVDKELEELEKTLKNIEEARPFEDLTVDDVAAARPDIDTRTADMIEKGRWMPAGYKEKFGELSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYG9</accession>
    <name>A0A2T6ZYG9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Neurochondrin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1079164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYG9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYG9"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="502" mass="55728" checksum="D12A3A63630DFC83" modified="2018-07-18" version="1">MVAEYSGDGDSSIITQATILQTLLVFSTGRKGSEIIVRIEDLSPLIKCSAEHETAMQILQYAFVNSVSEPLALKSRLKTFLPSICEDMLAMDKASRLRILSFLSDLLARFPSELLPSDANWVKSAYTAIRAVITSGHNSHERSHCIKIAASLLHKYPPSLLFEPKALGKAPAGEEKPFVYFFMQLALIDLRATFPALLEQLAAPCYGATAHRLASDFDVLAAFLGYLLMIEDFDDIPITPDLLLKLKADIGETFGLALEFLRDRWDAGYAGAAGFEPGFEKDVPLGLTWETKLEGGIARDPLVIAAIRALSLWLKEDESLRKEAGGLTDLFLGLWKKGKEEGVDYRFWILSSLEGTVEEDNGREQFLQYQGIDLIWADLKTICVNRNAGEEDLRIAFDETRVLTQVVMLEEKANEVWVKEVLAAVDIRGDSSMRLELDAAMARLASACLVKTHKAARRRLKDDVQKFKEVCGRLFAIVSEKMEGDGGIAELVGKAVEELDWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYL3</accession>
    <name>A0A2T6ZYL3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_716143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYL3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="196" mass="22612" checksum="03AF2D974ACEB8E8" modified="2018-07-18" version="1">MPMIFKSLPNQRPPGIQLPSKKAQAEPFPISPSNVVSTPRSGKKRKEGKKKKKQPCQQHCGAHTHHTPCSHSAVRKGLPTGFLSRFQFLPSQESLHKFSCVFLYTPISFLLLWDRQRRQRGGKTGARRGRRRMRKKSTIKVKHRGSITNMRSYDNIYVLVTDFLFFFFFFGLLHCMINRSLVGSPRLAGIMGRYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYQ6</accession>
    <name>A0A2T6ZYQ6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_717987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000061">
        <property type="protein sequence ID" value="PUU80613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYQ6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="84" mass="9337" checksum="784ED1CA1A8C68CD" modified="2018-07-18" version="1" fragment="single">RDAPARDHVFPHSSLLVLEYRLQEGHPCANVTPARPRIHTSLPCLIRPPAPLSDRKYPLSPHFPPSLTATNIPHLSNQSVQHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYX3</accession>
    <name>A0A2T6ZYX3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000059">
        <property type="protein sequence ID" value="PUU80697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYX3"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015438594" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13265" checksum="8F19674E97DC027E" modified="2018-07-18" version="1">MPRTSVKKTFLFFLFLLLLPHSEETLSSAEATYLCLQGNFFLFTLFPNEWVAQAAPIINAQRSSIWFYCSTGIPQWPKAQKCPLASTRTVPWRRRWDPKIKTEVAASVTPSSGGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZU7</accession>
    <name>A0A2T6ZZU7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1062975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZU7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZU7"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000004">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015551580" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="46"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18613" checksum="E7B1556059BF3C22" modified="2018-07-18" version="1">MRLSTLPLISLLAASVSAGNLFQQLAGNQMSLTGGESQKIPGKNPLQHCTDDLSEDVLTIEEVDLIPNPPVPGENLTIKAVGVLKDTVTKGAYVEVSVKYGLITLIRETLDLCDHVKEVELECPIEKGKLTLTKVVKIPQQIPPGKYTVRADAWLADDEHLTCLTGVVVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZY8</accession>
    <name>A0A2T6ZZY8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_665007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZY8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="171" mass="18667" checksum="7A50EA0D2D907A2A" modified="2018-07-18" version="1">MNRSRGSEEEGKGREGKRKRTPPVALAGGKARAFRHLCPVVPSNGRAFEAGTTRIRAIKSVFGSLVKKRLWVGPSLGREPNCLAASILFVEVEEMALFYCAEILLARDELGQASPRSESSSTVASFATSESSNYCAPDSLYDSASTRIPVLQVRVLEHSVPVTFKYENRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A068</accession>
    <name>A0A2T7A068_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_653923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A068"/>
    <dbReference type="OrthoDB" id="992545at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17975" checksum="CC266B86C4DD576F" modified="2018-07-18" version="1">MDERVVISSPFQTTFEKLNGLNHRVWLMRMQDYLMCEGLWDLTSGHEEILEKPKDGKLDRDYEKKWEKYQAQRLLIQKAIGTIRLAMTDDIAAIYHKESFTTPAKIWDHVVSSYETIANCEEDDHYIYDSCTMLGFRWIRPPAPISNPFPKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0N2</accession>
    <name>A0A2T7A0N2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1077518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000047">
        <property type="protein sequence ID" value="PUU81297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0N2"/>
    <dbReference type="STRING" id="42251.A0A2T7A0N2"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="129"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU81297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="308" mass="34872" checksum="3DFC97EB7FB5B711" modified="2018-07-18" version="1">MLKDEVRTNAYKNAIYQNAHLFKDKVVLDVGCGTSILSMFAVRAGAKHVIGVDMSTIIEKASEIVKINGMSDKITLLQGKMEEVVLPVEKVDIIISEWMGYFLLYESMLDTVLLARDKYLAPGGLIFPDKAHIYMAAIEDGDYKEEKIGFWNNVYGFDFTPLQRTALAEPLVDTVEMKAVVTDPGQVFSIDLYTVTAPELAFNVPFELHFNRNDFAHAFIAWFDIEFSACHKPIKFSTGPHAKYTHWKQTVFYLHEVLRVNRGEVIAGRISSKPTEKNKRDLDIKIDYQLQSDDSSRASAGSCDYRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A183</accession>
    <name>A0A2T7A183_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1166003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A183"/>
    <dbReference type="STRING" id="42251.A0A2T7A183"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="369" mass="40618" checksum="EAD01EA17EEC0953" modified="2018-07-18" version="1">MCRFLVYKGTNPILLSDLILNPTHSILTQSYDCRLRLDSLPHNGDGFGVGYYTTPTLSAEPCIFTSTTPAWNCVNLSRLAKKTASSLVFAHVRATTTGALSESNCHPFSYGSLMFMHNGHIANFKKIKRAIVTAIRDEYFLMVEGSTDSEWAFAVFLDTLHSLGYSPKSPPETQNERAGGGGGFGHGVLREAMLGTIRRLNEFLDEAGTGEPSLLNFAATDGHSVVCTRYVCSRTDEAASLYFSSGTRFHEYKEGGFYRMERHDRGQDLVMVASEPLTFERGDWVTVPTNSILTINKQTVLIHPIIDKYYQQNPAYSRSAAFVESKGMAAEPVVPSKSVKNTKKPGAMNGKDMHLIDADRLPSGSDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1G2</accession>
    <name>A0A2T7A1G2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1G2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="152" mass="17493" checksum="2E0B0A71FB54AFAB" modified="2018-07-18" version="1">MQRIFSVRRRLVRHHHRGTVWQYPQAPPRHRLHALGKFYTRKSLIQGLNYCPCCYCCCGPGFEEGGEGNQHSRLLPLPFLSSLPGLLRRGGGTHLSWSFGTIGTKCFVFLRCFLRVLGSRNRFSHFLHSVARFVSSAEGIRKSMLQTRVYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1G5</accession>
    <name>A0A2T7A1G5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lecithin:cholesterol/phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1099658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1G5"/>
    <dbReference type="STRING" id="42251.A0A2T7A1G5"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="493" mass="54962" checksum="6CCEF69437200735" modified="2018-07-18" version="1">MIPGVISTGLLSTLPQFVESWGTGEKSRPYFRKRLWGSWSMLRAMVTDRATWKAHVMLDKESGLDPPGIKLRAAQGFDATDFFVTGYWLWSKIIENLASIGYDPTSAYTASYDWRLAYQNLELRDQYFSRLKNYIETATKLSDKKVVLVAHSMGSQLAHYFFKWVEAEGYGNGGPKWVEDNIEAFINISGCMLGAVKGVPAVLSGEMKDTAQLNRFAVYGLEKFFSREDRAEIMRAMPGISSMLPKGGDAVWGNLTWAPDDLPSQNISNGAFIKFTKGNYTEAHANLSMSESLDYLLENSDSWFYNMIRQSYSHGVALSSAEVEANEKIPQKWVNPLESRLPLAPSLKIYCFYGIGKPTERSYYFHENKDPLSRLNVSIDTTVGGEGSDHGVVTAEGDGTVSLLSAGYMCAKGWRLKRFNPAGVKIKTYEMPHQPGVFDIRGGPNTGDHVDILGRQKLNELILRVAAGDGDSISENIESDIMAISERVKIYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1G9</accession>
    <name>A0A2T7A1G9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1106327</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1G9"/>
    <dbReference type="STRING" id="42251.A0A2T7A1G9"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="201"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="583" mass="66252" checksum="EE56F6E79A9DDDD8" modified="2018-07-18" version="1">MPPSHHTHSTHGSRTHPPARYMDVQMMHASHLFNSNNNSMPPSKQAVSATTEGATSTNPDNEYTSGESEQGDEDDTVELREPSEAGRRGYNEDDGEEVEDEEADETEMAEGDGAELDFTGDEIDEDMAGEEVNYRRKHEQEMVEEEASDQEDIEGEEDAQSISSNASSEEENSDDPDRIDPAISEEMERFAHTFKGFEKRYRLVNKIGEGTFSSVYKAEDLLYDHYDNSWDIDYKDEARWAAPPSKKRRTGHGNHDIGPVRPKYVAIKKIYVTSSPTRIQNELELLHDLSGCDSVVPLITAFRYQDQVVAVLPYFKHVDFREYFRELTIPHIRSYFKSLFRALAHVHDNGIIHRDIKPTNFLYDYRYGRGVLVDFGLAEREGTDSQYCMCQHSTTDRKDHRPPTLAPSAGYPKHETRPSRRANRAGTRGFRAPEVLFKCTNQTTKIDIWSAGVILLTILSRRFPFFNSSDDVDAMIEIATIFGKQRMKQCAALHGCVFESTIPTIGERGFTLEKIVLWATNRTATGSSKDNKDDAKLDQDEALAIKFLQRCFELDPVKRTSAVEALQHEFLASPDWESPEPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1J8</accession>
    <name>A0A2T7A1J8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1190926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1J8"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="314" mass="35133" checksum="CCE1F312E04FEB9C" modified="2018-07-18" version="1">MPLEQSIVNVAPFTSQIFAHGAPPKTINYLRDGLVGVDRLQYHGPHSFETAIGKHINGFLSNRATQYVVFSPITQQEFEDIKNIRNAHHKELRLMHIGNQKTLIIKCGASVVHQLANRVFARCFEEKLFEMGLNSELEPMGTAMFSGPGSEKQADSAFKPSSRPFVDDWPTLVFECGVSESLGRLQVDAQWWLENSAGDVKTVIVISYSLPERSIHLEKWELADTPHPSDPSIFPPTITEEADIIGEKVLISAKGVPKISFVIDFTKIMLFKPLVRRGQDNFTFSKKDLVDFAGRIWRNSQTRPASDSDHGVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1P6</accession>
    <name>A0A2T7A1P6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_971267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1P6"/>
    <dbReference type="STRING" id="42251.A0A2T7A1P6"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="81"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="289" mass="31923" checksum="75AB59424BE057E1" modified="2018-07-18" version="1">MQKFGLETQVKRNPHPDFKSVESSRPPFDEGTSFSYTKTIKPDWVPGSGANNDDWKNHKTVEIDPYGEGRKPVDNYKLLISGIIPRPIGFVSTISSDGLSTNLGPFSYTALVNHDPPIFCIGFSGGVDNPKDTCRNILETKECTINVISEFFQEAANYTSINSPHGVSEWVLSGLTPAKSTKVRPDRVAESVFSVEAVYRTHHEWVSPGSGKASGVMVILEGVNFHVREDALNEEGNIIDPAVLRPLSRLGGITYGRTTDGFELPRPEFTKEVEKEEVKGLVKPKTQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1S2</accession>
    <name>A0A2T7A1S2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1S2"/>
    <dbReference type="STRING" id="42251.A0A2T7A1S2"/>
    <dbReference type="OrthoDB" id="5383967at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015563049" evidence="1">
        <location>
            <begin position="17"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="337" mass="37705" checksum="B348430FDF086AB7" modified="2018-07-18" version="1">MVNLLFLLLVLLFSLATHLEAPTVDAWIAGDVDQKLKEWWESIPDRTDRNFVSELGKAFGDFEYNLACRVDTEDQCVNPSCNVFLGAKAPKWTYFVQVAISNLNRFMRLLHSDLEKFFKKLLVAWFVNSEIRTHTKTFILCSNSIDPESVGSPSEAKYITCNGTRVCNLYRLDSKGELRDLIAVETLKQPEYNITARDMVHSSVEAYLAKGLNCTAEEMTSRLQISATLPPDQQWFSQGAAGEGAFTIPVYDVGKNTEWMGSGMTCFCEVGCEDTKSFMESAKMGSFDPVKNECEKIFPVSKTLDYGISNAPSLSKASWRTLAGVFFATVVANFLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3A0</accession>
    <name>A0A2T7A3A0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_969199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000032">
        <property type="protein sequence ID" value="PUU82180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3A0"/>
    <dbReference type="STRING" id="42251.A0A2T7A3A0"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="5">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="239"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="331"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="482"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU82180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="520" mass="56892" checksum="737F54DB539DFA35" modified="2018-07-18" version="1">MSGIHPSRRAYVEEDDSDMVDLANVPIDRDYNLPQNIKSGIAPEKASAILSQMDRKKKAAAIVVPTDDGRVRARLRELGEPMTLFGEGPGDRRDRLRELLYQLQEGNAAEGSQAGDMDMQDAAETPEPDEDEEEEFYTPGVPGLLEARQWIANYSLPRARARIAKQKVEASIALQRHIKHRRAIKERLSGYQVLGSQIAGERSVAISRFSPNSEIIAAGSWSGSIRLLTVPNLEDKSLLRGHNERVGGITWHPQATISLSPDSANLASGGGEGAVHLWSLTQDTPIATLTGHSARVARVEHHPSGNYLASASYDTTWRLWDLPTQKELLLQEGHSREVYTVAFQTDGALIASGGLDSIGRVWDLRTGRTIMVLDGHIREVTGLAWSPDGYRVVSSSGDATVKVWDVRMVRCTATIGAHKGLVSDVRFFSGKQDPVVAMNGTDEEQTAAAEAMRTEGTYLATSGFDGNVNIFSSDDWALVKNLSAHSGNATSVDISRDDRFIVSSGQDRTVKLWAREDIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3B5</accession>
    <name>A0A2T7A3B5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1159244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3B5"/>
    <dbReference type="OrthoDB" id="5355583at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36276" checksum="7DF91E00AD3302F9" modified="2018-07-18" version="1">MFRLATKQVVRLAVVYRYLPHVRAISTTTSQTDPKPKARSSEVTTKKDTDLKKRARSKLETASGEGSKEVDIHLKKPKTKVRWTQKMSYSKVSIKDAEERLSLRLDIFENYGIPISEMLGQADPGIKGLAGHELHQVKDKVFNNILSFLLAVGYPAQDAEPQKANIIDLAFLIILPILTAVQRTNERRLSLRRGKTIMSNDSKTWGYQELVVIDIVGIGNRKFVFVVEPKKVDLALAKKRCYLALKDMRDNNARGVVYGFITTGEQWQMVSYNGQDFTQTKSFLVLSHDMENKKETWMKESAIIVDCIHTALCSGGFGVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3P8</accession>
    <name>A0A2T7A3P8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1075093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000029">
        <property type="protein sequence ID" value="PUU82377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3P8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6269" checksum="B299EE05B3F4583F" modified="2018-07-18" version="1">MIHASIIPAARFRSLYYYIIVVLYPSLCLYLSLSPPQISAGTNAGIILSVVMIIIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A481</accession>
    <name>A0A2T7A481_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_382568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000026">
        <property type="protein sequence ID" value="PUU82495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A481"/>
    <dbReference type="STRING" id="42251.A0A2T7A481"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU82495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="20057" checksum="97CFB5097D259AA8" modified="2018-07-18" version="1">MSATPAERALVVPAPTAAPATAPAALPAAPDKAGMPYYEKIRKDLRDMIQRKRGLDKTLAVYEENIAKCELTYLEDTQNGNIVKGFDNYIKGTAARRRNNIGDADRIFSHSSLTSAATKLKQQEDNTPVTNSSTPTVAENAPRIGTTVRNKKKRRKGEDESESPSEVETPGPKRVRISFSGQGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4W9</accession>
    <name>A0A2T7A4W9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_349653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000023">
        <property type="protein sequence ID" value="PUU82740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4W9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="93" mass="10344" checksum="0364DD9151C3AD4F" modified="2018-07-18" version="1">MLRALFNVTEVGYILCSCFRSLGIGYVFGISPNDLEKVHLLSGEESQNECPYRGSPNEETVAAIDTQLTHPLCPKGPRLTPWGFIQPYKLTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A537</accession>
    <name>A0A2T7A537_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_966490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A537"/>
    <dbReference type="STRING" id="42251.A0A2T7A537"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015656336" evidence="3">
        <location>
            <begin position="20"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="135"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU82861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="334" mass="35595" checksum="631B1E4842DB2E33" modified="2018-07-18" version="1">MLSRTILALLAAYAAGAAGSPAGMPQDAAQDRTIEELLAMDSNLIQGDVVTFSATGSVPTISGPTLAEMYYYAEFAAAAYCDPNNVPGTEVTCKDNICPEVTANSVTTIIEFANTVVADTTGIVARDDTRKAITISFRGSHSLKNWFANFQLLWKDASVYCSGCKLHSGFYNAFAEAFPSILASVTSLHAQYPSYKLVATGHSLGGALATITATEFRRLGYTIELHTYGAPRVGNNKFSTFVSQSSGNYRVTHLNDPVPRLPPVALGYYHISPEYWISYGDSNIRASDVKIYYGILNTGGNSGQGLITLNVTAHSKYFLPGGISACAPGGFDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5D0</accession>
    <name>A0A2T7A5D0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1073961</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5D0"/>
    <dbReference type="STRING" id="42251.A0A2T7A5D0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU82918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="508" mass="57399" checksum="3272C0686A996927" modified="2018-07-18" version="1">MELAVKSFLLLATALYLLLKLTAYLLIAHQNRIFAKSHNCLPPGRLPSSFLGLSNWVRLTRAAKRGDILDHIVSRFPIYGNTWKGRILFGTSIGTIEPENIKAILATSFKDFDLGPQRHDNFYPLLGDGIFTLDGAGWEHSRANLRPQFSREQVSDVEALELHVQRLMNRLPEGDGEVADLQPLFYCLTLDSATEFLLGESVDSLLSPELNPTGAARGGKEEMSFAQAFNVSQAYLVQRSRLRELYWIINPKRFRDANAIVHRLIDRYVDMALHPEKRARKAPEGKYVFLDAIAAETKDPKYLRDQTLNILLAGRDTTAGLLGFTFWLLARHPHVYQKLREEILSAFGTGLNNEGKRPSFSALKNVTYLRYVLNETLRLYPSVPLNGRTAVRNTVLPRGGGEDGLSPVFIPKGQRVDYTCYGLHRRKDLYGEDADAFRPERWEEGVGRGWEFLPFNGGPRICLGRMFPHLLVIVVAVGRLLTPSVNRAIRPDRSLLHSYQDLAEICED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5G1</accession>
    <name>A0A2T7A5G1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="5">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_966268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000020">
        <property type="protein sequence ID" value="PUU82905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5G1"/>
    <dbReference type="STRING" id="42251.A0A2T7A5G1"/>
    <dbReference type="OrthoDB" id="5405067at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="13">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="16186" checksum="A88308667FD8610A" modified="2018-07-18" version="1" fragment="single">AGLCVGGYNIDSTGAKSTAMYKLVEKLLAEGVPVDGIGVQAHLIVGNVSSTLQTNWERFTSLGVDIAITELDIRMTLPVDEAKLAQQAEDYKKVVTACVNVERCVGITVWDYIDKYSWIPGFFPGQGAALPWDKDFTVKPAYEAIATALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5S3</accession>
    <name>A0A2T7A5S3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_965484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5S3"/>
    <dbReference type="STRING" id="42251.A0A2T7A5S3"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU83092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="226" mass="23834" checksum="FB380C359BC8B72A" modified="2018-07-18" version="1">MGTLRKLLEKHGKRKAIVGLTAWDYPSGLLAQRAGGIDMVLVSDSLGKIVLGLPGSIGLSLDDMIHHAKAVARAVKTPFLLADLPMGSYEISPEQALTSAIRMIKEAPGVSGVKLEGGKEIIPQVSKITSAGIPVFCQVGITPQRTIQTANDEEGTGRSEVSASEIFDDAICLQNAGAVGIMLTAVSQEAAKLMRDHLTVPTIGIGYDLLAFRVVCRVGRACLTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5V5</accession>
    <name>A0A2T7A5V5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Swi5-dependent recombination DNA repair protein 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1098813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5V5"/>
    <dbReference type="STRING" id="42251.A0A2T7A5V5"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527">
        <property type="entry name" value="MATING-TYPE SWITCHING PROTEIN SWI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28527:SF1">
        <property type="entry name" value="SWI5-DEPENDENT RECOMBINATION DNA REPAIR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25314" checksum="77A18F93679E8B5D" modified="2018-07-18" version="1">MPDSPAKSSTPNSSVMPKGSIASDAREEKRRRLSVATNTLSKPFRSPLLSKPSSTATTPSPTKSIASSAGSPTSPVTDSPIATNRRRPSRLFTTRQTSSTPQNPELAGLYKQQSTLEAKLREKKALLDTAKQALSIEAAAEGEKKLQASIETWRAAGRNAADELYGITSQRVANAGPGGWRELIRKRGWDDDERQTAYEKGGEEDEFTMGVMLKTLGIDLKLIGYDQDGDCWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6U8</accession>
    <name>A0A2T7A6U8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation transport protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1119143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6U8"/>
    <dbReference type="STRING" id="42251.A0A2T7A6U8"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU83454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="591" mass="65748" checksum="4AC3822D66B110C9" modified="2018-07-18" version="1">MRYVGDIVEEAKKNTQLQRTVSAARRSRENARDGNVESGIVVLRAADGSTLPTQTTQTSSNSDTDAAPHSPEAPTSSRIVWDVPTPHSSRNANQTAEEKAHYYDTSRSTAGATRRPSIDTIHEITDAGDLTGANTGTSSRHPRALSRENSLSRSRSHLSFRKSMDNPPAPYLSYTPSIGRNSRFYDLTEEQRNELGGIEYRSLKTLVWILVAYYIFFHVLGVIVLVPYILRSLEYGKIMDDLGVNKTWWGLYTAMSCFNDVGFTLTPNSMISFQRSTLVLMLGGFLIVAGNTGFPLVLRFIIWCLFKMCPERYPDKRDELNFLLDHPRRCFTLLFPSGPTWWLFGILIVLNVADVVLFLVLDLQTPVVESIPVGYRILNAFFQAVSTRTAGTASIPIGSLHPGIQCSYLIMMYISVLPLAISIRRTNVYEEHSLGIYIPPGEATEGQKGEGKGDEGTYIKAHIRRQLEFDLWYVFLGLFLICIAEGRRIADANDYAFTAFGVFFEVVSAYGTVGLSLGYPTINASLSGTFSTFSKLVIVAMEIRGRHRGLPYDVDRAVLLPSVTTPDSTFGPDGSRFERAKDRETGKDEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A6X2</accession>
    <name>A0A2T7A6X2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1072453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A6X2"/>
    <dbReference type="OrthoDB" id="10499221at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="183" mass="20560" checksum="25304D419A46A0B0" modified="2018-07-18" version="1">MRVFAENLRREEALGGADPMDIDFENVIVVGEPSDVDAGRSGVSIPNTVRGKAFRYAFIRLEAEIDRARARGRTRARANRVNSCGVGRPSWNPDVRLHNNLNWHTEKILPPSTGFLSFLPTSDRRVIMVGYIFLCIASDYGLRIVWPTFTSTYSSIFAVIMMVLGLFFVRIPDSLTARSDSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A705</accession>
    <name>A0A2T7A705_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1141642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A705"/>
    <dbReference type="STRING" id="42251.A0A2T7A705"/>
    <dbReference type="OrthoDB" id="5366676at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="300"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="553"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="819" mass="90982" checksum="392941AB5018B801" modified="2018-07-18" version="1">MSLSMGLFSRRKNSEDKASRAALSSPHTNSFASSSSTRDGCSPLPLSPHSTPVMRPKKSKLFTKAHPVSVSGYTADSGGIGFAPHLTRAKTTNFNSLPPTPQQHRHRQKQPSMSGLMRSSSDASGSWRARPLDQRAPQLGSHMEGFMNIHPSSFPHPPSPALPHSIPLPDSPAALQDRGRAGSGSGSPTPRLPLSATGMDYRSHPNHGFYSPPPSRYPISPPLSPESPLGTPAGRFDEPVHKSEGELAMEIAGLKEAISTRDHLIARYASNFNIDEINDAVSEMKKSEGQRVHQILSHRIHDLAMANSEKDNEIAQAEQKMNNLREALNAELGSLREAHARERLETPDGVGLEDLEDLDRYRRRESELMDVVNGKEKELELLRERVSVLEKSNARRQIQTLDEDRVFIGGKPALVAISEMGLADIGRKLMDEIRRRERAERKLAEAATKSRSDHDVILPEERKKGETSASASRGEELKPRENIDYVLSEEEKRRTELGWQFNERLETLRQEKETFETKQSAATQREGNESLIEMKKNRQLEAKIDQVIEDALNNDLKNVVEDRETRITFLESESAIEEAWHSLESELGYHSATLAERDERIKDLETENGNIRDRLEDSLDLPISGDSDKDVELYKQDIKAYRRDLKKRDAQIRDLNRIVADLESHLDSKSPPLSPPPVPPSTPISCPPTPTTANLVEEEYRSTHAAVTAQQNMIITDLDSTIEATEKAMKRMQANFLQLSQIATAEVPLPPLPAGAPLPPGSPIIPGSPERSRSASMGSPVIGSISGSEEKKEMERRDKTMSVVNEPDGALGEEEVIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A756</accession>
    <name>A0A2T7A756_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1105071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A756"/>
    <dbReference type="STRING" id="42251.A0A2T7A756"/>
    <dbReference type="OrthoDB" id="5406684at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37048">
        <property type="entry name" value="QUESTIONABLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37048:SF2">
        <property type="entry name" value="QUESTIONABLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="303" mass="33650" checksum="1FFD7A1388A61E82" modified="2018-07-18" version="1">MLTAPQEGHIYWLKDTSESQSAKFDSGKLNHPVLVLGAERAGSVQALVITSLGSTTLSAKFPERDDRRRKKYLPLGVAGAVPHPDNGILLSVRAGRPPILTKPSYVNLEPFEVEVRFLNLDKRSTDSLGSGMLERLMGKLLELYPRFVPHPERSSSQSSSQPPARQPRVSLATRPQPLTQQSAPPPPPPPQRAYSNTSSTTASRQDHRENTEWNATRLPNPVTRPQPPTQQSSQPQRAYSTHYGTTPRQDYRQDLERGTVRPSYSRPHYHDSEGESDSISGWNVLGYLGIAAGIFVAARYLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A763</accession>
    <name>A0A2T7A763_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="7">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1098575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="7"/>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A763"/>
    <dbReference type="STRING" id="42251.A0A2T7A763"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000002">
        <property type="entry name" value="Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="8">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU83567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="519" mass="55527" checksum="7E4E0BB1C0F5BFAA" modified="2018-07-18" version="1">MAPFLRTANGFIRGERKYSFLLARTFTSTSRRFEINKIYPSATEAIKDLKSDSTLLAGGFGLCGVPDTLINALHSKPSVRNLTAVSNNAGVDDSGLGILLGSGQISKMIASYVGENKTFEKKYLTGEIEVELTPQGTLAERCRAGGAGIPAFYTPAAFGTVVQTGELPVRYNPDGTVAAYSQPREVRVFDGKSYVMEEAIRGDVAFIKAWKADSLGNCQFRFSAANFNGAMGRNATLTVVEAENIVSVGDIDPAAVHLPGIYVDRVIQSTTPKSIEKYTFAKDPAATTAEEQSAALGTGETASRRERIIRRAAKEFQNGMYANLGIGMPMLAPTFVDPSITVQLQSENGILGLGPYPRRGDEDPDLINAGKETVTLAPGASIFGSEESFGMIRAGKIDLTILGAMQVGMYGDIASWALPGKIKGMGGAMDLVSNPGKTKVVVTMEHCDRKGNAKILEKCIFPLTGRTCVSRIITELGVFDVDFEKGLTLIEIAEGVEVDEIRAKTGAPFAVSDELKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A792</accession>
    <name>A0A2T7A792_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_821575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A792"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="92" mass="10550" checksum="CFCD51042EF7601B" modified="2018-07-18" version="1">MGHFNSLFLLLRVQIFNHLFLSLGSDCVLWVSFISTFGLTGAFSGYKKLNASVTGRNYRGTSYEPVETLGWTGFWEMVGFSFLFLTLFIFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A797</accession>
    <name>A0A2T7A797_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1118971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000009">
        <property type="protein sequence ID" value="PUU83611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A797"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="178" mass="19649" checksum="0014E8E50AB9A9B5" modified="2018-07-18" version="1">MSFKWFLDRPDNRLMPWLKLAQNDVESAPESAGYSDTCLFIGHEQRSSMAYLYVDINGIIVRAIEPLMPGLVAGFGDTLRLFDAGFIGLRYQGDEKAGESEIQVCLGPVILQAIVVVVSHPPPAFLTLASTMVKNWMQSRWAETPSSGKTVSHVSSFDKDVGSISVHQGQLIYKTKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7D6</accession>
    <name>A0A2T7A7D6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1118779</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000008">
        <property type="protein sequence ID" value="PUU83643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7D6"/>
    <dbReference type="STRING" id="42251.A0A2T7A7D6"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000001">
        <property type="entry name" value="Probable kinetochore protein ndc80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="92"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="15">
        <location>
            <begin position="420"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="295"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="538"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU83643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="672" mass="76378" checksum="A44DD76D0F46846E" modified="2018-07-18" version="1">MSQDPNLFSAFKRPRETISGIPSSGMYNSGIPQPASALKRSNSNSRSSNSRMSLAARPAHNQPDIMSTAKRDPSRYSARKSYAPSSHPPPSQRRSSVMRRSSMGVAAFSQMNSFFSSAASAAVQRDPRPLKDSGYRHQIAGKVFEYVVNNGFELEMKYALGPNSLKSPTQKDFSMVFQWLYKRLDPNYNFQKAIENEVLPILKTLRYPYASTITKSQLAAVGSMNSWPQFLGILHWMMELVVTMKRFQSGEFDDAAAAEGVDIAAEKIIFRYFTRCYSAWLVENDDHDEFLKEMAASFEDRQSGYKEELEMLESENEKLKKQLEEIDDPLKKLEEHLIHLEGDKKRFVTWAERREPHIAKATASNQRLKEEIEAVERELAELTAEKKSLQEAVDRQGLTPADIDRTNNDREKLSKSLSLISSKITEAKIQLAERESEASSKLEALERSISRYNSLAYQIGIIPSSSRNAEGKDFELLILPTQTPENKLLADEVGYQPAQLLNRDLRHDIKPALNRLRQEIGARIHEAQDEAIKTQELIDCVVETLADKKDEVDTLQAKLRTVVDEYQELKETLAAEGNSSNAEIEKLEKELASMRLNMPNGALALEQRMQSVTIERDQLEHACHALREKFHGEVDKMLHEVIKFKVHIQESLENYENLAEEELADNDKLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A886</accession>
    <name>A0A2T7A886_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1104797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A886"/>
    <dbReference type="OrthoDB" id="3219467at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1405" mass="153149" checksum="D7DAB195D6C81FA6" modified="2018-07-18" version="1">MSSTGNVSTSTLNNNSKLTTHRWSTVSRLLPNQKHKRPKLLDITLLHRRKQSLTPDDPHKIYQSLQSNDTRLKLQGTRIKSPKLITLSPTGELVESEKPSSEDAPPPGFVLGGDVKLFGSRLAGRLYTFVGEAGKASDVKEIIKLGEKLLLKDVLSCLRGSAFGDVGLVRPGFTFRAGDSALGTLPGLHFDAEVVFDNDSGLKSVRETLGKVFGVKGGSLKVSGHLGEKREWNKVLKPEKFSLKGMFVGVDSKLGKLVRVTSVGVELAGVRVEGSLGKRAKYECTVGFHGSAELEIPGSVVPLVVEYGLKEVQGMYEFKLTKGGNEWVNVVGFKGLKLSDVQLLAQFPRGSSIKDISFQLSTRLQFAGTALALKGVYSPETFYIQASVPTCTLDDLHTLCTSITGRTLTEFSHAATFKDLLFRIDASGLTLSGDVTIDGHRAVQAAVAIHRDGISITGSLKDITLGSVTITKAQLDVFIGRTNPGTTSRTGGFSITGDVHFRSIDISVTVHTLVEGGQVSWTVYGELDADLRLESLAPKVKGTFLDLSLRKVAFIASNVDSPAGVEEFNVFNYPIRRGVQFCAALDRITQLDHISGGRVEGLVLRAAYSDRGFSFGILFPAPVTLSLGPNVTSGPLSLEVVASTIPQLIFTTTLNVKVAGQAQPLVFTFGLKADMDSAEGFGQMTNYWVNPFGLSENVKIGPDLAFELGIIYAVIASTGTPSKIGFSGGLAIGDAETQVAVALSENPTEQLVKTSFTRLSITDLIRFASRIANKAIPIPPEDLFTIKNGLFYISTGATIGTTYYPAGASIRGDIELFGQETNLECTIGRTTKIQALFEEVALGPLVVTGTDGGKVSTVIELGLSKQHILLDGRVRIFDFEASMHASLDILPKPDISFALRVAWADALEVELCARVIGIVDFKDLKGVDFVVDVVLEQHILDYISTHAQAHFVAIRKVFEDGVEAAEEYFENAKEAIEAQLKEAEEAFDAARRLWEEKEVELKNALHEAVSSFEEGLEELRKDLCQAEKDFEAAVYNAHQRLETARIDKVAAITCALINVRKARRELHAEIVSHLFAIQETKKETAMNYGALLVDLKDAEEDVQKSQDEVDRREKALAAAQMELSEAPFYRHIDLSIKVGHHQAHVTDARGDLLSAQKILTKAQSALEQSGYRSAISKKTEKKQLLAEVKATGERTIKDTEEHLEIATKEHDEIIQKTEAEIEGHLRKHSSIEGLALINKEEALKQFKSEKETQISTLKSHVAALPETPEFEKLEKAKRELTEIKNTKLQLGAAKDAIKLLQEKAPAGKHVESVMAGLGHVFDIQRVELHGSLRDLIEKGIPLEARVKGFIAGKEVDFVLDYKIGETGRFVKGLMGKWWEEVSGGFIGLLDGEEKGKEKGGEKSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8C9</accession>
    <name>A0A2T7A8C9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_652063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU83996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8C9"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="153" mass="17559" checksum="1BC1AC0DC0FF4029" modified="2018-07-18" version="1">MTFFQNLHINHFHHISYLNFTFTRPFIHFIRITNFNFSTINLLMLPPTFLPLTPPPPFHAHRLPTTTKLPTCLPTYLPTNASEEKQRKHKRPPNLNPIRQKKKLHNSSQVNPASQSHALSPSSSQLAGGSQKKNTHIDNQNSHTTIDKRKEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8N8</accession>
    <name>A0A2T7A8N8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid/polyamine transporter I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1118388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8N8"/>
    <dbReference type="STRING" id="42251.A0A2T7A8N8"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="540" mass="58065" checksum="98BE9428701F4C06" modified="2018-07-18" version="1">MTKTGSPKKSYAGSEVLSAQTSLLARNDEEASLDIAPVIEIPTAAGNSHQLTLFDGYSLLVSFQIGSGLFSSPSQINNNTPSPSAAIFVWVAGGLLAWAGATCFAELGAAIPVNGGVQEYLQYIYGDFAALLVSFTWIAAVKPASMAILSLIFAEYWTRAIFGGGADTFWLDKSLAICVAASLTLFNSISTKTSSNLNGVFSLIKLSTVGIIAALAIIVMFTGLNAQGSGPSMDWKTRNWFASRPTEADGHRVDWASLTVWESMGYFSAALWAGAWGYGGWDNANIVAGEMRNTARDLPRAINLALPTVICCFILTNLCYYIIIPWDVIGATDTIAVAVGLKTLGAAGGLVFAVLVSIACAGSLNANIFTTGRFTQSAAKKGYIPKFWGVQGWRISSEESTSSTPTYGTTDSPPESLHKSPESTSWRTPVRAMILNCLLCCTYALIGNFGSLVAFIGIAEYSSYLATVSGLIYLRYTQPDLKRPYKPPIWRPVLFLVACSVLVLRGMIFARTQTGILAVYVCLVSIYYKYLWKGRRGVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A979</accession>
    <name>A0A2T7A979_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_893630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A979"/>
    <dbReference type="STRING" id="42251.A0A2T7A979"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="71"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="408"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU84297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="564" mass="61765" checksum="AFB80D192857B066" modified="2018-07-18" version="1" fragment="single">MASPFLGVYTAVYAYTPRDDQELTLEEGDLLYILEKSSDDDWWKAKKKSTGEDEEPIGLVPVTYIEEAKPVGKSKALYSYTRQTDEEVSFTEDATLDIYDDVSDPDWALVGYNGEYGFAPTNYIEKIGAGEGNLPTSPTAASPPSPVQAPVTASKHVSFSSPPREDTPPPPTPPRPQSQEYSPAQSPAANVAAVMHPRIPQHSPRPSASGMASPTGSASQSYRDRDQERNYERGHDRGHDRERDRSHERRPAREKKYVRELSDSEDEDGPRIPFRRPGQPRHGVEGGHSHGRDSPPIPPGFQTYPVQEVDSRKKRAATLGLGPTRIILLPDKSTRPKEEWSVENLKGYNVEGKHVFLELEKPSRSLDLHAGSKDAAEQIISALSEIRGAVKAAGISEVFAAAASGGGKRNDIGTVLCDFAAQGEDEVSVTTGDEVLILDQSNDEWWLVRRQVNGMEGVVPASFIERGRSKVVTTGIMASPSDPKERVRAHEHAGGRGASGIPRRTSSLAGNHSRDDRRRRPDSVASDQAGSGKQKPDSSQVRQWTDRTGNFKVEAQFIGCKDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9K0</accession>
    <name>A0A2T6Z9K0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1097924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000696">
        <property type="protein sequence ID" value="PUU72172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9K0"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9K0"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="69" mass="7430" checksum="EDF1ADC2437134FB" modified="2018-07-18" version="1">MVSNKRAQAYCLSKGQLPHFECSAKDGANVDVAFEAIARQALAQDESEIDYFDPTVNTGFPIENGGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9Q0</accession>
    <name>A0A2T6Z9Q0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000700">
        <property type="protein sequence ID" value="PUU72166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9Q0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="186" mass="20871" checksum="358E2C27B1CFC74E" modified="2018-07-18" version="1">MSRQPQANSRSQPTPRVGNLSGRRREAVSDGVRSARSRSGTQQNQSSNSPSTLPNGQSSHLHHAPPNATGALERPAKRARRRTIQSTTYADIETEHDAQAPTETVRLSDESSDEYQNSRGSDQTESDTEQMQKTMIFQKLLEQGCVIGHKQRTDKQTIAYRLCEFRPPPDHRRQHSLGGRQQLEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAL5</accession>
    <name>A0A2T6ZAL5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_660509</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000517">
        <property type="protein sequence ID" value="PUU72509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAL5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAL5"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000173">
        <property type="entry name" value="Heat shock transcription factor Hsf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="8">
        <location>
            <begin position="194"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="725"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="625"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="731"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU72509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="766" mass="82109" checksum="3F802F80461F267F" modified="2018-07-18" version="1">MTTPPHPQSQPSGSSNNNTRGRKRPAPGTSAPILSSVPATAEPTLITDSGMNYLSLPTAPAGISSAGPGGNLYAAGSGLADSFLAGRSDVDQNTAATQAGAINLPITANDSTGRLARVNRPGNTLIRMPYPLATAGAMAQGLVAPGVQMNLLNGSGGTTNMGQVMGPGPQSDGLDPFDRDLHMRIEKMRKKRASIPPFVQKLSSFVNDPKTDALIRWSPSGNSFLVLDEDEFSRTLIPDLFKHNNYASFVRQLNMYGFHKVVGLADGSLKTSEQRSKPPSEYENPYFKRGQPDLMWLISKPKGKPNKKRKNKQDPDTDKEDDLSDGGEGEFGAGGVGVGYLEGPKTDNQGDGHHQQGGSGGRGSRPDLQTLIQQLEAVKNHQAMISAAIGRLRKDHNQLYEQSVAFQTLHDRHEHSISAILTFLATVYDKSLGGHINGAFNNLFTQNQVEHGHGLHSQGVGSVVGNTGGAILTPARPAQGVARTPQMARRRQLLLENGPPGQISEEDSNPGISSGNSQPPKPNGSPIVQNFQTYQSPSIQELVTPTHDNRNPSPHQEQQQQQQQQHQHHGSNLQNYPSPIFSLPDSPTAQSTPQMGRPSTSPVLAKSTLTPRSFNRTLPVSGVNSKSLQDHNAQLAQKAKQIEELEELQAAQNRNVDGLMDMIHGFEDGNSIGELDSFLNWDPSQDFGAGVDGQQISDVADMNEFLGFQDSDGLGANVGDLLPGQLLGADPSTVAPSPATSSVGSRPREELEEDVEEVTPKRRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAP8</accession>
    <name>A0A2T6ZAP8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium-activated chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1059541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000504">
        <property type="protein sequence ID" value="PUU72572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAP8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZAP8"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="795"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="85"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="860"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU72572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="904" mass="101807" checksum="02C6EC86A994D828" modified="2018-07-18" version="1">MDRSRTRSLSRDHSPSRSNSPPRAGRSYSRNSRSITRSRSRTRSPVSNRSRSPTQSPVSRARSRSGSGSRGRSYSRSASPEIQSTKIVIEKLTKNVTEAHITEIFSSYGEIKMLDMPLNHQYNTNRGVCYVIYHSSSSAHAAIAHMHEGQLDGAVINVSIVIPRRSDPSGPGSGPQARRPPPGPRYRGQTGNRYRSSPRQSHPPPPRASNQGVDYVISFRFGSTAKEKAEAQFEKLIAALDSVGLRTEARDGANGSVLVFVTVRSEQKLIGEVYRSRVKDWLFGVRPAAPDKETQRSLDKEPLTEAERLRIVHKLITLPVGEGGVGITPKQGPWTLVESIFPLHDHDFNKAWLKDWSTTWIVLREELEKLRDRFGEKIAFYFAFLQSYLSFLVIAAAFGVGSYFLLPQYSLVFAISNCLWSVIFVEYWKRQEVDLAVRWGVRNVSQLQNKRAQFVHEKEVEDPVTGEVVKFFPAWKRLCRQLLQIPFALGASAILSALYAAVFVIEIFISEVYNGPFKSVLVFIPTVLLTLFVPILTSILTKIAARLTEFENYENESSQEAAMTQKIFVFNFICSYVPLFLTAFIYVPFGNLIVPHLDVFGLTVQPFAEDEKPTAAPVFQINPDRLRKQVIYFTVTAQIVNLALETIVPYVKRRVFRKAKEFQNNRKGFENAGKVNDSKSEHAFLKRVRDEAELDEYDVTTDLREMCMQFGYLTLFSPVWPLASASFLINNWIELRSDAVKICVEMKRPVPHRADSIGPWLDNLAFLSWMGSISSAVLIYLFSDSATAAGTPKDLTLWGVLAAIVFSEHIYFATRLAVRTALSKLDSPGLLKERRERFLVRRRFLQESLGVDEETEVHDLEKVDHGAQAAPTSSSAFWSQQRGPSETIAAGKGIIESSLSKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZAS2</accession>
    <name>A0A2T6ZAS2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000499">
        <property type="protein sequence ID" value="PUU72588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZAS2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="266" mass="29257" checksum="D13E9F445A66292D" modified="2018-07-18" version="1">MRDCYVTACWDNHSILPLWLPRSSQDPGTLQALIDTWFPTIKDKLTVIFEYIDTDIKSSALLVHDTAFNNTLTDHNVDASLTLSEDSTSRNRAFSSSPLSVKSIPAQSLEGRQGFKYSIEINTENFEADTIRSLSESSLISVTELISQVRKCQQLISDPDQCPTMRDEPVSPLDHISETSLSSIPSTPSLPQPQLISLTSLPPQQTQLSAVSRLQRSPSPQSQDPAQGSLPGISFLPLVAILNNFVSNNRTDSFPNLPLIWASTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB47</accession>
    <name>A0A2T6ZB47_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1136899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fungal fucose-specific lectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000478">
        <property type="protein sequence ID" value="PUU72711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB47"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012475">
        <property type="entry name" value="Fungal_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07938">
        <property type="entry name" value="Fungal_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="460" mass="50671" checksum="8D1BB9586857A04A" modified="2018-07-18" version="1">MLSQQNIASQHSQSPQELEGADPYLSSEYNTSPGALHMPGPGLGDNQKEPDLGSGIEPSERKIWGLKRKTFVIMLGIFILLIIAVACQSQQSQNPQIAKPVVHWSKALTWRQNSPSPASSGGHPSIVTVTASISSSPIPTPIRKNTPFAAVNWNNGYIQLLYKHTDGSIRLQKNNGSQWGGQLAQVTKPKDDSGLAAIAWLDGDVRQVRVYTAGENNALTESVWNSSSRLWYDQGINDISTSKGIAPLAAGSHLTAYTWHDGKVLHIRVYYQGQDGYIREAAYDSTGHKGWWKGDSPAIQDFPRAKSGSGLAIVSFPDTNAREAKLFYQNMDGELRSFDAKPAATWVKTWQNFGFLRSLFGNGYGIYGAQVTAVSCILATGELALRIYFIRDGKLVEIWWTRKAGWNSWYMHDAVAPGVSTISSTDDVNVFFQTETGHFSDMSLNRHATQWQFTPIVQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZC37</accession>
    <name>A0A2T6ZC37_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperonin 10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1006271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000419">
        <property type="protein sequence ID" value="PUU73058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZC37"/>
    <dbReference type="STRING" id="42251.A0A2T6ZC37"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="13"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU73058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="350" mass="37401" checksum="061B66640976ACEA" modified="2018-07-18" version="1">MTTMKAVKHQPQGSISVVEVPIPDIKEGQYLVKTVAAAHNPIDNSIIDYSLAGGPGSSVGFDFAGIIERTGLGTSGRFSPGDRVAGMVHGCNTHTPTEGAYQEYIPAEEHVMWKVPDNIDLIQASALGAAVVTAALSVHHLLKFPVPGEGKVEEGTWLLVYGGSSSVSQAVIQFAKLAGLRIVATASKRNHELVKGLGAEYVFEYKDTDECIKNIKSVVGDDLRYAHDSISEGDSTRIVLDCISTKGGKVACTIPIPPEKATRKDVEMLTLDAFAAPGKAYSFMGNDYPASLPIKEFIKKFTPIFEKLLAEGKFKLQGIRVIPGGLEGVKDGFAEVKAGKANQLKLVYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZCQ5</accession>
    <name>A0A2T6ZCQ5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000403">
        <property type="protein sequence ID" value="PUU73194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZCQ5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="125" mass="14379" checksum="D4CD4A50CB3B6018" modified="2018-07-18" version="1">MLKRKEQGESQKKIIALEERVIVLSKPISEREKRRTVLKKIVTGDEEKNIGPSGIEEVVIGGIIVAGGELQKVKKKRNQKKQKPKAAVKEDDLNEFGIFKRWKGTDADSQERNWTKEEWDLHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD41</accession>
    <name>A0A2T6ZD41_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1135183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000378">
        <property type="protein sequence ID" value="PUU73410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD41"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD41"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU73410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="150" mass="16321" checksum="EE53606BFBCF29F0" modified="2018-07-18" version="1">MAGANSGSPSPTNKPDQKSMPLILTTITTTTSSSPFNQRCEYAASVRKLLVDARQEVDKCKPESDRTVLLFTGGWIPDVLLATRSVEIGIESNPQVSRRLEAATTKILALDIDFVSIESWGYSESSRIQYMQLGIAKRILSTVTPPTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD50</accession>
    <name>A0A2T6ZD50_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1069034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000381">
        <property type="protein sequence ID" value="PUU73376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD50"/>
    <dbReference type="OrthoDB" id="4776289at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="215" mass="24601" checksum="ADE378377EC3CA0D" modified="2018-07-18" version="1">MFYSNSESRYGVFHWGVWMQRGHESMGPVITADTNKVGAQLRIHQHDLFASLHNTSYPKGFSPGATDKTERDKMQKATQALHDGDKDLWCKSDTECFALRACLVNVWTEPHVDCSDMEWAMISPFGNFDNGEFCIADLERRFTFQEGYIAGIRGKRFVHFTRKWSGSRICLVSTMHSAVFRQYAKRHDSEEVVSAHGTGESEEAEPPQKRAKRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDD6</accession>
    <name>A0A2T6ZDD6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1162988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000372">
        <property type="protein sequence ID" value="PUU73489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDD6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="152" mass="16885" checksum="683B7220CDA24497" modified="2018-07-18" version="1">MSANNPNRRKTPHNQRMDDPPLAHLACAPAKTPPATLPPTPNNQTPNQTPLPRPEIRIPQRYLPHIVLSTHTPTSQADMIRSGTQTGSLFHQTSTNGTRSIGIAAVIKDSEEVESIPKQWINFEDLNPLFPDKRNPLQVEHPHKQARGVAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDG8</accession>
    <name>A0A2T6ZDG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YT521-B-like domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1135006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000369">
        <property type="protein sequence ID" value="PUU73541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDG8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDG8"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="937"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="889"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122657" checksum="BFF9D058C3F2A74B" modified="2018-07-18" version="1">MSLEGRIGNPRSPEQRMDSHHPRQLRSYGHYNEGGRSHPDSMPMDGRANLRSYQQEVEISYDEKPRAPEGNAATVDAYSRSEGDKSEGGIVDEGINQGHRSKSNGDTSQGLDLDTPNNPGTASTGDATQNVSKDEPEPSLTNDLTSETQQSGKGLNSNHHGSTDKEAGNMVNPKDTLSTKDPNELRQKVLESLAEKKKKAAVFITQESEGTSRKEASPESRIGPIGMNTTEIGSGNDKSPTKASASNPEREAAVNALLAEAMGSSKTVSSKVEKVPGASASSTAKNSVKSPIEESFDQTRRRKHYPEEPKASGMTRRPSGELRENTSPIYDDTEASRRSSFAGHHSYPRNDKQARPKRSPEDLPRREGAYKEDYSHSSRPKISPASASRQEFPRAQRTYEHEERDRSDARQDTRHRTDRFEDPPPSAKEFRHPPEKPSASRRGDGDHRGKYLEEEKLRAREEPSSYRSMDVAREDNPRDPYPRHSRRMMDPNWQDQGPDAPPYPAGRYLPPRDDHRLPPITRPPETDYAALYYKDLTEWLELTGYHDYSYRQMVLRHQRDIRAMEDRRKALEDDRDGPRGYPGVPLREDIDPRDPRRARGQPSYPLLPSEMPPRDDRDPSSRVPEGTAHRSSSRAALYPPLPRLDDRARYQGDFRVASPPGEVGSLKRRAPFRDEYDDAGPVGKSARVNYESQHRSTATLKSDDYVNAEQFGTHIKHHSGHGDPVDHRHPSRRVTKDRFEDPEDDAASAVRQSLPKRVATSRGREQSPPPLPLEARVRERSLSPRHGYDNNDRKEGHKQGPPNKPHRGGDDDAAFVHPQRKGFEKGRRTPEPSGPRYEKDFQKPGRSASGKFTPREDFRKPFPARRSSSDDYRSPGNTLRRSSLDEHKKKPFGRGRGRGYTKEFHPSTRHNGRPDYGDPMDLEKRVGPVIDTRGAGTRYFVVKSFNHDNVKMAQKDELWATQKKNSEMFEEAFKTSRDVILVFSVNKSGKFQGYARMESAPGTAPIPTWAKNLLWESSGPFRIRWITINDINFHRVAHLTNRLNEDQPVLIGRDGQEIDPECGAALCRLIDDSANFHRNYNENGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDM2</accession>
    <name>A0A2T6ZDM2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ureidoglycolate hydrolase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1034665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000365">
        <property type="protein sequence ID" value="PUU73583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDM2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDM2"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU73583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="232" mass="25023" checksum="53E3A483197A4601" modified="2018-07-18" version="1">MMAVSPGPGPDGPESTMEKMLRSVSATQPGVRPSPSESIQRLPDGSTIITAKPIMCDSFLAYGQVIGIPESGSILEEQTKPVSANQGSARKYPNVAAYDTAPQDRHPSNTMISIFVSKPRTEAPGQFDLHVMERHPYSSQLFIPMGVKEEEGFRYLVAVSPPGDPKPIIDNVEVFLVHGKQGISYGAGTWHAPIVVLGKEDVQFAVVVDTNGNPQDDTEEVEIKEKATVVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDS1</accession>
    <name>A0A2T6ZDS1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1134817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000360">
        <property type="protein sequence ID" value="PUU73640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDS1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDS1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015563898" description="NB-ARC domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41716" checksum="5727FD8677DCA4F6" modified="2018-07-18" version="1">MAFTHPMFRYFLLALAPQTWAPATSEVLKFSEDFRAIAQHVRIPPASAETDETELLLSVRRWFEGSTSGGWILVIDNADNEADFFADDSPIAKFIPQGINGTLIITTRSRQVALQLRCEMIETSLKDKEKEDVPAILDSVDHLPLAVIGSAAYMFENGTPPSSYLAILQENEERMKSLLSYPFYGIQREARAKSILSTYFVTFDQIRQQMPLAADLLRVMAFFNHQNIPEELLAQCIPERMEHSANFRCAIGKPSGFSLVKRDKYGKKFYQLDRLAQLSLQAYLPTKELNQGRTTALKVISRLFPQPQDGPRGIDPAYIPHALAATRDSTDPIAEELGFCVALHLLDIRSYDSAEIQFRGCTALREECKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZE58</accession>
    <name>A0A2T6ZE58_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1068725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000347">
        <property type="protein sequence ID" value="PUU73773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZE58"/>
    <dbReference type="STRING" id="42251.A0A2T6ZE58"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU73773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="384" mass="43673" checksum="3E8D17B3781BD355" modified="2018-07-18" version="1">MSGAVFKEFRSVMKLDAIFKEIKEAIKTRSHDIVEFHDVDPREFEKVEQGLRHRSNYLEQYCLRIHWFAFQKILKVIMPLKLHKSPAKWLYEMIQRGLVAGLITEVWVESIVAQFFFKIRRHFHNRSLTFGNNGKALVERLGGLSTDPWISAIVAVWKVIIKAIFLQTINGDLLKLVYYYSRFRMLPSADLSMWLKPKPKLMLFPPLPPSFSLSPVVHTSPVVYTLRSLSHPHCRRISHRQQRAPEAQGQCAGFQLEAREVGNGPEMGRIRMWSEPSAPYNEAHTSLCARKAICEIEGLDDKDLDTIYKGPASSAIMIRSEMEPPPLSPSSAGMKGRLDAFQPTNRPCPRKKSYNLNAPSTNPNTVTISTDNGDLSSGEDIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZET6</accession>
    <name>A0A2T6ZET6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000330">
        <property type="protein sequence ID" value="PUU73976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZET6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZET6"/>
    <dbReference type="OrthoDB" id="5323643at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015445150" description="Beta/gamma crystallin 'Greek key' domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18437" checksum="68A5DCBE4D11BFD8" modified="2018-07-18" version="1">MQAKAFLSYLVAAILAVGVIATPVGVEGTSTTDVNAVFENVGDSASFVGAPPDPRPIEPIITPKEGDVPAPSNTSVVAGDHGSLKKRTIGCVRVTTNQNFGGTSARACNLPNGHCVNLNPFWRYRISSFSPDPYTFCKIFTGPNCSGIGSVMFGSPGYGNLGIWDNNMGSLECWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEZ5</accession>
    <name>A0A2T6ZEZ5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1093761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000325">
        <property type="protein sequence ID" value="PUU74053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEZ5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEZ5"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="149"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="307" mass="34384" checksum="793CDA0A13E85EEC" modified="2018-07-18" version="1">MEGNKKRRSNNESLDPKSIKKSKTKEYWKNQAKAKYHSLYSIEEGSQGIFATCDRGREARCVEEMYRLLEQVASELYGLDLSGDKNDKDEDEEVEDEDIGASIQQEINDLKGAKPEKPFISVKLDIECVIFFRLNPPCEPTAMVNALCAGTLENRLKSRYVHRLTPVTRIGKANAEGLEAVAKEVLPSYFHQGEECIKFAIKPTSRNHNHLKRDQIIKIVADVVGTKHKADLKNPDLLILVDFYQSICGMSVVKDWETLKKFNLAQLQEAKTDKRQGGSEGVTAAVSETTATPSVPVVQVEVPAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZF66</accession>
    <name>A0A2T6ZF66_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1068415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000320">
        <property type="protein sequence ID" value="PUU74148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZF66"/>
    <dbReference type="OrthoDB" id="5403850at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="471" mass="51924" checksum="DD451EE65885F77A" modified="2018-07-18" version="1">MALERGTIIGILAGVVGVIIPLLLIWFGNCCVTDVARMRDRRGEDADEEGGRGGSSTTTTAAAAPPHDSTLMSLRTFAPALRMRFSYPPATRPISTTPHLFAGGPRPKKHRTYKKAAKKTPHKSNVLSATSFQPRQPFQKNRKPPKIGPERAAHPKALPKAPSRDIIHYIPPSNPLRSRLGPGMYYNAKVSPSRRYSTPLDKDVEAEYLYTLMLRKVFGTPIVPTKSVALKYAMVRCMEATGSHSKAASTRLRKGFLAEALGTKITKKKAWVCDKARATAFDWDLHENMRFIRGHLFTGKEVDYYPPEGQIFGAQALEKTNFEEERGKRFRKAMAILQGDNDATTTTPSAEAAAASTTPTSKIAGMAVASDYDSDGGDSDGKIRDDWVLEDSGSDTDFEALMIGEEDGVISTREGWVDEGSGPDTDIEALMTASDEEGEEWEEWEGDEDEDEDKNKTGKNRWKGRWGGTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFK2</accession>
    <name>A0A2T6ZFK2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1093318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000312">
        <property type="protein sequence ID" value="PUU74236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFK2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU74236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="88" mass="10367" checksum="6D3E831CE46435BC" modified="2018-07-18" version="1" fragment="single">MTSAGSVSTRMHWRWVYTGIIARMCRSWAATIGVWRFSVFFFFLQFRNAGTRSGCMIHGGSLWNWSLVQRLVYFFWYILKVVIDSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFT9</accession>
    <name>A0A2T6ZFT9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1093167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000308">
        <property type="protein sequence ID" value="PUU74284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFT9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFT9"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="122"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU74284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="346" mass="39532" checksum="A839A59904379905" modified="2018-07-18" version="1">MRRKLNALRKPQFRQSWSKYALYNMSRAPQPRISSQKTFFQQKWAAKAEVRQYHGEHLTNRQWQNIFRHTMKASVPMQNTRLAVDNGSEMAMGRGSGLQGDETYGRVRTVPYMSQLFWPMERRLDMAVHRAMFASSARQGRQFVVHGFVKVNGKKMVHPGYMLNPGDMFSVDQDQVLFATGKPKRSFKGAEGATETAAAEGEEKAEGEEGKDKAIAKEGETVKGTETKPEEEGAEEASSPIVSKKSSTEAETEEEIKRREAKEKLKALSEDPNNVLDITKPYATPWRPRDYMAPFAFIPRYLEVNHNTCHAVYLRHPVAKPGLAEAPSPYPEEILQMAFNWYLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZH45</accession>
    <name>A0A2T6ZH45_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1132706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000277">
        <property type="protein sequence ID" value="PUU74724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZH45"/>
    <dbReference type="STRING" id="42251.A0A2T6ZH45"/>
    <dbReference type="OrthoDB" id="5489704at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU74724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="545" mass="62802" checksum="2A9098A54B76AB6B" modified="2018-07-18" version="1">MVGKREKSGRRVGPGNLRARVGKVEKAKGGKGLLDDRKYRVVGSGELVLGGKEVDWKVYKGFKKVVGGWENDEMRLEDEMVLDGSELGLSGKGDWEVWVDSMEGVEGDDERNSAEVVEEAIRELRRKEKEAIGEEKEKEVEVERVEEISESEKEVEKKRKVDKGKEKEVIVIESSGVEELGMLEKWKVEKKMKEKKERDESKKREKEGVINRGKDKGMGRDSTLELWREWKDYEELVEHARYILGIRKEEARCFMLDKEIRKVLELGLEKGLGTRKCGDNECRKEVEVRSEVVVEDGLKEKEELKMWKAVVGGRSYSEALKGGESNRRGDGLEEKKDVEIKKWLDDSLAREERSGKVVKVIMDSQSRKSKEEWKVEEVMGKLGISEHVVDKMKVVGNRVKMVMKDREVGEKIEGMGKVVLGEVIGGGVEEVKRNEVWVGIVVPGMEVDMWEGKMEMLKEKIEVENDIKLMRLPRWLANEERRKGMGLKRVGVVIHVARESIRVRLSEEGLKWKGKNWEGMLKVNRYIEERQLVFCTKCAMVRHNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI82</accession>
    <name>A0A2T6ZI82_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1090976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000246">
        <property type="protein sequence ID" value="PUU75189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI82"/>
    <dbReference type="OrthoDB" id="10253919at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="396" mass="44242" checksum="9BA3FDC4447762FD" modified="2018-07-18" version="1">MTILPYFNPPAYLTDFTKENADKWSKDHISEWMTQSASTPEVTQFYNATTHSTEGEINKKVITWTAFPNTVKHNTPGKERWKVADSTRNNQDEYCEWSVLRNEKGEIKKVVFTCEGPEYWDALATYQPDTLLQLYKDSNPDYASQIKKEDLYSSGRYDRRNKWNNSTTTGSIMHLIQPANTLEAEIQLGADATVLRVDSSGTPIHDYDRLIRCSQYGGIYRNSDPTIGGNVNDLAWQGPLLTLADPVGLYLEGFDGSQFVAPDDEDVQKFWKFTRGTPEDPSLSRPAHWVRAVFEVPESYGYNVSDIKDTNGNKINWGSQLADAIQIKLIGQAAEIGKHLGQKRRCKGALAAMAVATAEVAGMSAAAEMGEDDTHANLEGTRAHGLDIEAQGYVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIA2</accession>
    <name>A0A2T6ZIA2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1103054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000242">
        <property type="protein sequence ID" value="PUU75228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIA2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIA2"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015520829" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="172" mass="18371" checksum="9FD465E4ED1E41CD" modified="2018-07-18" version="1">MQTKIFLTSLLATFLAVGVTATPASVKARDVRTDHIVDFSKVANSVGSVKPPPKGQVITPKDNDVPVVGTSVKARDLESLEKRTAGCLYVTQDANFSGPSAYLCPIATNGGCTDWTNTWRYTISSFGPDPGTTCQIYTDPNCGGTASVAFGYPGYGKLGGWNDNMGSFRCWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIS9</accession>
    <name>A0A2T6ZIS9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-NOT transcription complex subunit 1 TTP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1067477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000235">
        <property type="protein sequence ID" value="PUU75382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIS9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIS9"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="156" mass="17636" checksum="7007B43A921732BD" modified="2018-07-18" version="1">MVWQAVRDHDPSSTMFKCGLQALVQSKDRLKEWKSYCGLLAQVSGLQGIYTWKIAQNVISGNVDRLSEPSVNGNIDQGEPGAVLTNGDFNASSPESPQHPLFQSLDPTMPFRDPSAYTEPDEEVQDRVLFVLNNISHFNLEAKLEFLMEHLREEYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIW5</accession>
    <name>A0A2T6ZIW5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobic surface binding protein A-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_355702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000236">
        <property type="protein sequence ID" value="PUU75354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIW5"/>
    <dbReference type="OrthoDB" id="5422100at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015750835" description="Hydrophobic surface binding protein A-domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="20503" checksum="69F5FF9F8F957D8A" modified="2018-07-18" version="1">MQFKLLAAALLTASVARAADLTDLNSRVTSVAAGATSVIGDINSGISAITNAPSSIRSKVDSAISNIPSDINSAVSSVNSQITGAAGDLTSKAGAAASKVDSELSKYTSVISGYSSIKSDFKSVITAGPSAVSSYIAALPSNIDSSARSALASALNSAAANVAPSGTSGSGSSGSGAKSTSTSTSTSSPSSAAGRNALVGGILGAAGVLAVALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJK6</accession>
    <name>A0A2T6ZJK6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP synthase j chain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_993601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000219">
        <property type="protein sequence ID" value="PUU75663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJK6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJK6"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7153" checksum="4FAA27A0A5568B6A" modified="2018-07-18" version="1">MLQRIFGRKWPAPVAEPMTPFYVAGGVIFYGVYSLSNFLANTEEYRNDPRNPNARANPPGKAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK11</accession>
    <name>A0A2T6ZK11_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_307467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK11"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="207" mass="23540" checksum="21E506CC4460E573" modified="2018-07-18" version="1">MQASNCSHEFTTPYRHHLHSNHTLTWEYQTRSYQENSPPIKPEKNMQKSGPAKIREGANQVSHLQRPSSRKPSHEGPIWKMLVQGAEKEPPVSPYSRTVRRKPTNPPLLAACCSPPPALISHPKFTESKKGSRREKNKTLLRQVIYHIRSNPLNSRSGEKPPTTRNPRTPTTIGSIPHIINHFPPSESLPVANLKHVNHRVFYGAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK74</accession>
    <name>A0A2T6ZK74_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_992876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000212">
        <property type="protein sequence ID" value="PUU75856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK74"/>
    <dbReference type="STRING" id="42251.A0A2T6ZK74"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="294" mass="32551" checksum="CB55FD26F08D2A26" modified="2018-07-18" version="1">MASSKLKASDLRAYDLAAAGHDGVLSDESGALVIKPCTAREVAFYTSAAEHPTFQKWMPTFFGTLELSGPEPTAGPATHDRNTSIVMQNLTYGFDEACVMDIKLGAQLWDDEAPQEKRDRLDAVSNATTSRSLGLRIAGMKVWKGKAAGGYKVFDKHYGRTFTADNCLEAVKEYFSADISEEQKKLIAERFLKKVTEIREVLEGQESRMYSASLLFAYEGDGKALETALKEEEENAKKPPKDEDDDSEDEKVKKVEELKLIDFAHANWTPGKGPDENALQGVRSTERLLAELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK93</accession>
    <name>A0A2T6ZK93_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Centromere protein H (CENP-H)-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1089340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000209">
        <property type="protein sequence ID" value="PUU75919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK93"/>
    <dbReference type="OrthoDB" id="2274804at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU75919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="183" mass="20205" checksum="30541B0D1F58A3B5" modified="2018-07-18" version="1">MQDADDDLSIEEQLRIAEAELLGSKANSVMKGKIVETTLATQPVLRAVHLSSRSTPKERALSPLILRRDVLSVTHANLSHVLGASLETLSKLQASNKNAQVLNRQLTARLLTLTEKKKKARQAVARDDQGYRAAEEALREAKIKWEVMRNTLQAIIVGSGVDWVGDKKLRDTVLSCGEELELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKI5</accession>
    <name>A0A2T6ZKI5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_992292</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000207">
        <property type="protein sequence ID" value="PUU76007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKI5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKI5"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="193"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="423"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU76007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="948" mass="105780" checksum="A15F4B2B74772502" modified="2018-07-18" version="1">MENRSSTRPRASLSGEHPNLRERQLPNSNIPPPPLPPPPLPPPPHHQQSSSTTYHAKRTNPEPISNSSSGALPPKRPRTGSEEQRQWQNRRTDGGGGGGRGEIKVAPDWSGNETTDHEGEDQHQRERYFGFSSTPTSSALMPPPSTPQIYRDTQNEYSLAHPKWGLRREVVMGFSHCGIEQMYPWQAECLGMGGLLAGESNVVYTAPTSAGKSLVADILAIRKVVNERRKAIIVLPYIAIVQEKTKFLKRVLEKVRVAVPKRGRWDKVNLWKQPNIVGFHGGSTARMGWKELDIAVCTIEKANALINGAIEDRTVDQLGIVVFDELHMLDDDNRGYILELLATKLLCMAEENIQIVGMSATLSNVKVLATWLKAQFYECAFRPIPLQEHLVYDNNVYSYDEKLVAKLPPSKLKELKDPVTNAIVSLAYGAVIEDHGVLVFCESRRRCEDVGKLLTKFMPVVDEEVWEKRMEVVRDLATTSTGLDFTLEKTVPAGVAFHHAGLTTEERDIIAESYDQGAIKVICCTATMAAGVNLPARRVIISPRMGRDFLSPTMLKQMRGRAGRKGRDTHGENYLCCRKEDLAPVKELLNAPMPSIQSCLGGETACLKRWALLEGIATKLATSTDSLNEYMRATLIYHTTPEPMKHLKPKILNAIEYLKEMKLISEDRTHGYFHATKIGNATVASGFGPEEGVFLHDELSRALMNFNLESDMHIVYQFTPLHSSTTASVDIDWKLMREEVEKLDESGIRAATFVGVNPAFVNKMAQGGTLREDSPQNISKARVYRRFYVSLMLRELLNEKPVHVVAANYNIARGFIQQLSTTCKGFATTSGTFCKVMGWTGLAVLLEHYSWRLDMGVRADLMSLARIPFVKSVTARIFHENGLKSVEAVSASNVEALMKLLELAQPKKLRLREAEMGKMRGRLEKRAGIILEAAVAIYEQDCRDAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKS5</accession>
    <name>A0A2T6ZKS5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1029490</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000202">
        <property type="protein sequence ID" value="PUU76097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZKS5"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05698">
        <property type="entry name" value="S1_Rrp5_repeat_hs6_sc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000065">
        <property type="entry name" value="Programmed cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000279">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="139"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="269"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="369"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="463"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="556"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="646"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="734"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="833"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="945"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1146"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="89"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="900"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1224"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1254"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1295"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU76097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1609" mass="176831" checksum="CA4F7016D9BD14E0" modified="2018-07-18" version="1">MGSDKKRKRPQDADPGPARESGTKKSPATANKRLRPEPSAAASKPELAKQSTLRASKDEEVSFPRGGGSILTPLEFKQISNDAAKDVLFETENVKAKSTKKPMREGLRRDKKAKKDEPKKDEQKGIKAEGLSYKRLLPGTLVLGCISQINKTDLALSLPNNLTGFVPLTSISESLNQKVEALIQDSDDDEDEDGEGKIETARSESSEDDVDLTSMFQIGQYLRAYVVSSSEPANSKSSSGSKNIKKRIELSLDPAMANSSLTAAELVIGCTIQASVTSVEDHGLVMNLGIGDDLKGFLSSKELGKGRSVADAKEGQVMLCTIVGLSSNGKIVKLSGDLEQKPSKKGKYSGGKAAWWLSSAPTVNTFLPGTGVEVLITDIAKRGKAVGIAGKVMGLVDATIDFFHASGWEEKDIESKFKVGEKIKARVIATYSEPRKLALSILPHILSFTRPIENEPTTILPTATIINSAKVLNIEPKTGLFLDVGVPGIPGFVHISRVSSNSKIEALSEDSGLYQTGSTHTARVIGYNSMDGLYLVSMEQKVLDQPFLRVEDIKIGEVVKGTIDRVLDSGRVIVNLAEGITGMVDSLHLSDIKLKHPEKKFREGVEVKARVLLVDRSKRRVRLTLKKAIVNSDAPIISSYEDTTPSTRSVGTLVKILPNGAIVKFFSDVCGFLPVSEMSEAYIQDPLKHFTVGQSVNVHVLSVDPTKQKLRVSCKDPNLFGEAQKEALAKLPPGGVVSGTVVEKSADDLFVEINGLGAEGIRGVLVIGQLTDGSREKSLSVFKKLRAGQKLDDLLVLEKHEERRSITLSMKPSLVKAAKDGSMISKFEDVNEGETVKGWVRGTTLHSAFIGFAGGIVGVVYKKDLPAEAQPLPNFGYIKNQSITGRVVYIDPSERRFRLSLNSESPREGKVSPVTDTAGDSERLTGDTKSTKGELEKKEKKLVKGMVVPGRVTKVTDQQVFVQISESVFGPVSLTDLADDFSQAKTSKYSKNEVIHVCIIDIDPPDSKNLQNRFSTPELNASNKRVTLSTRPSRVMSSDLPVKDPEIQTITNVKVGDIRRGFVKQASPKGLFIAMGGNVTAWSKISDLSDKYLKEWEGLFTVGQLVRGKIMAVDSTLGHVQMSLRESDISGKERPKPTDYSTLKKGQIVKGSVKNIVEYGVFVRVDGPQNISGLCHKSQIADNAVEDISKLYAIGDPVKAKILSINPEKKRISFGLKASYFENEGSEDESEGESEDDSEGEGGVDLSTVKDFESDANEESDDGEEEEEEPEVKMTDEPAGEGLSTGGFDWSASILDKRGLDTDSERDTSLEEERHKKKRKKVQIKEDLTGNLATREPQSVADFERLLLGDPNDSKLWIMYMSFQLQLNEVEKAREIAERATKTIALREEKEKQNVWIAMLNMESMYGTDETLEEAFKRACQYNEAQGIHEKLASIYIQTSKTENADDLFKVMIKKFSQDPRIWVNYADFLLSSKQNREAARALLQRAMQALPQDQHKDLISKFAKLEFRSGDPERGRTLFENLLATFKKKSDLYNMFLDMEIKYGSEEDDGKEGVRALFKRALAEKTSTRQAKALFKKWLGFEKSKGDEKSVEAVTRKAKEYVEAKKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZL77</accession>
    <name>A0A2T6ZL77_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000194">
        <property type="protein sequence ID" value="PUU76250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZL77"/>
    <dbReference type="STRING" id="42251.A0A2T6ZL77"/>
    <dbReference type="OrthoDB" id="5499495at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="632" mass="71418" checksum="587614254CC28D1A" modified="2018-07-18" version="1">MSQNPRGRPSKSAEHKKHVKKVADQKRYVQRKVDANSISTHSRSKQYQENQSHISNTEVEVPDVPSAGPISSTTSRISSFTTIRNPARWVSEDLEEGVSEKEFENQGSEDTIIHNDFQSVRWPKVVGLEQILQDMEIVEEPTFLNIQETRAGSEETVEIPHQDNLIQLEENDKEDQELERRRVSAWPKVLGLEQRMQNMDISLEDCFQNSTSTRYLDTEGICMVQEDSENENNHMENNSSRKGKNVLRISHISDLGHSKLLDLMIDKDIEFQSAEDSGAWIQRIIIDLLEANSSNSSDLISNTISSSLQSPIILFPDSELGTSPSPSHTIPSQPTINSVIFNKFDIIEIFSDSDSDKSSPSLNLKDTTNYLIQQYSYNFACSSHTSSSRSTSTISPSWSIARMTQWLNYHLPNDFPKPEVLGYGGRVSSHQWSSLLCGISSESQTPPTLELPIPHLSIATTTTYDIDSFIAKVKCLSVASKGVRVQFTTSSQKNISSDVHLFSKIEERLASEKHLPLSFASASMNTFARGRELGIQNREVYSAKRQELHYFLSGRYLKPIWQDMIKFSESTGYNHFEGMFLLVDAKDLKLQLKSSSISGSWELFKNILDGDLNFKCLDENFQFLDLGQEISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLC8</accession>
    <name>A0A2T6ZLC8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_263325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000195">
        <property type="protein sequence ID" value="PUU76224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLC8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLC8"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU76224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="50674" checksum="02929307A3E4F09C" modified="2018-07-18" version="1">MRKARSAHVKCDCGERLALLKESKAAGKPASVTASTCHSSTATTAPPSEEGDPKDTSSACPCCHGGRCTCALKKELLDSVPELAAPATCASIAPSATATATVETRKPRLQATHSEGSLTTLHTFANGHHRPTHKHHGSIHGSSPYTIPLVGHTGHTFGEHIGGCTKAPAATVSAPPSAASQKPRRIKSEHSSPDLRSYPALKMANTGITPLELTPQLPLQPIKSVSSRVAPGLSVNTNTPYTMHEYRNQELLPSADSECSFQFSAGLYPPQSAGWPPAYSGFDNAPFDEQSLDTGVDYSVSQLGLGNYLRYQQPSAGLNGSVSGDEIDDFISPVNGPGGLGGARTVTRSSSSDTSDQAESDFGVSAASSFVGLQQASSGILAGNSFEDLENLNAAMGPMQPTDPSYGLIIGTVDGALDSETRGLSLYGGYSDGYLGLKDMATTKATELGGVPSSLPPADDGDYLWMAAPPMGTNSAQDGAPPPERWMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLQ7</accession>
    <name>A0A2T6ZLQ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exocyst complex component Sec6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1102413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000190">
        <property type="protein sequence ID" value="PUU76420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLQ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLQ7"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU76420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="737" mass="83987" checksum="76D705A7619DCACF" modified="2018-07-18" version="1">MEVPGLIIVFAQDLDKIASLKSEFSRKKGHVDTQLKAALATQLKVTQSGIGAINDGQKILNAIREEMIKIDKLCSEAEDMIDEFPLINKISKIHRNFVAVEEIKSKLQGLDSRLAEVDRMLADDSGDSLGNEMPNLLPVHFAIMQLQDFKEDVMHQSERADNDVKETLESYFSPLENTVGMFDERVVIIAMGLIELIIDTEERSDEKVLALQEAQNNHQDLATRFKSIQKGPKVARGYKEKFLACVKAAAQAKFEAAKEQFEGDPEGLEQCLGWYFNDLRTVKTEFVQLMPRRWKIFDTYLEIYHNLMHDFLKDQIEKPDLDGQSLLNIILWNGEYNKGMKTLGVKAAELKPQLIDGREAELLKEYSQLIVKKMEEWMSKIMEDDTKDFILRTHQPNEEDSKWHMPSVPTMFTMINQQLNVALDSNKGNVVTGVVDECVRLLKNRQVRWQEVMADEINKHVKATTKEDLEDLPDGILEYMMAVANDQIRSAAYTQEISDRVAPMLSKKYEDQVRRALEDAMNGFVDLATYSLAQIIEIIFNDLKPPIKNLFTPAWYNGSDMETMATTMRSYIVDLSPGLDADLFPAFMHQLSEKTCVAYLGGVHNKGAKFRASEAAAQIRSDVAVGYGFLTEFVDRGEVKGVWTVLEHFLALICSEKPLLGEKYDAFKQSYWDLPVTWVEAVIKCRDDKSKDMLEIVRSRGTYVPRGGESTIMSRFVAPLVAQVIASVWFWWRCYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZML4</accession>
    <name>A0A2T6ZML4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1129388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000179">
        <property type="protein sequence ID" value="PUU76686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZML4"/>
    <dbReference type="OrthoDB" id="5479481at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="151" mass="16419" checksum="257F97F2690CDD8C" modified="2018-07-18" version="1">MLSQFDKRDNSGNPERGSNDMSPGETLAIVIAALTLLVAMIPLFRCSRFHRWVSSLILPFVKKAFGISPPKPALTAVITTDDSSAIPAPEIPIPGPVFIYNRYSNSRCIGTCSGAFVGGQNDIAEEDGRVPQAEESLALRRPERVVTYPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNA6</accession>
    <name>A0A2T6ZNA6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_988567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000168">
        <property type="protein sequence ID" value="PUU76967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNA6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNA6"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="364" mass="41072" checksum="423BD157F441F62D" modified="2018-07-18" version="1" fragment="single">VSELHKRLSTGKTISASQWREMGYQMIDDRKYSKALRCFEDAEDPSGIALANAYITEQNGLSYRALGSFEMANRNFIKASEFFLNARSIAKAVQCRKEGGDPKGAVKILADNGAYEDAAWLSADIGSFLETSEIYTKLNKHERALAGYARGKQFKRMFNYLRKFEAEIEVCCRKQYVLFGYLKEFGESDATPGEPEKRVINLFGSLAEQQMVLSRLGMMSKLFETLRTNRKYMEAYEVGVSYGLAADSVRLLSENLLFKSLNRKQEAQLETVCGFLQAEYIATNPWPRTRGGGGIHKVLRAATGRGSSQINSFVKVWEDINRALDMSARHRTRIDRGKISDMQIASYVDILVCCSMRSSCDAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNG0</accession>
    <name>A0A2T6ZNG0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1194354</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000167">
        <property type="protein sequence ID" value="PUU77017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNG0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNG0"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF356">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="505" mass="53869" checksum="1D8A6A40E88262F1" modified="2018-07-18" version="1">MENFCAVCWITHSQDRHHIGILKKCSTCSVTFFSKSAFTRHMRDPRSKCHPTEFHCCDCDRGFPNASSFNIHLATAHPNFRAPPPARTRGIHHCEECNKSFETAGSLRSHRANSRVHNPLLEKKVGCIGKCKREFNAPSSLLAHLESGFCKSGITRDKLDNAIVAQDRTNIITDPVAVLARKTANLSLTNSEVSSICGGSTFDTPDDSSDAVSVYAQSEAFDGHPRYSAAGGVLLTPDASSFEASSSGGSGIWTPSGDSTGTATPTAGVSGSGGIPINSPPFSTAGFSSAGNFYTPSTSSIASNQLAGEPTIDQLRSWLLPDGTFECPICPPNTATFTRPSFAILAGLQTHMQSPTAHPQLNHNLHTLFSDISIASSESGIATPSTIPAQSYLLPNGKYECPLCPSGSRRVFKSLAVLQKHMLSPIAHMPKIYHCPDPELLGIPPSASARGRKQEKSFVTLSALAQHVESGACQGGRSMFKAMVGFVNEKLVNVGMGDMKMIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ03</accession>
    <name>A0A2T6ZQ03_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_157745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000149">
        <property type="protein sequence ID" value="PUU77569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ03"/>
    <dbReference type="OrthoDB" id="5486507at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU77569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="159" mass="17361" checksum="ED575BE49482F4E2" modified="2018-07-18" version="1">MSAVSRFPIKNLLSQLNKREQKDDQGGDHSDDRSPVVIVGLVIAGLTLLLAIMSYRHSRTIRSQAVSSLLPSHFSRNPSHQGPRTLLSNLPTTTPSADFTGANPIIIYNNYSGARFGGHHLSTFSYQNNTVFSEDMGATRGGALWGSRGPEPEVTWPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQC8</accession>
    <name>A0A2T6ZQC8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1108743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000145">
        <property type="protein sequence ID" value="PUU77685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQC8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQC8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="617" mass="69933" checksum="0F3A43B104671E13" modified="2018-07-18" version="1">MNFTVSDPPRDKGLSKEWNTIFSQSSAAMLTPLFLTTALLFMGHTCYSLHTQLCKVRPLGIPYFVIPFYPGPLPRIFLIPFVQLLIKVFGLTHPQFFLMTLDWQVRQRYEIYRLTGSDIFFIVTPWKVVLHVADPDMAVEVLAGKGGNGELYTRPEIFSSMLGLFGENVFTAEGAVWRDHRKITAPVIGKSWRRLSVVWEESLTQIQQMIRYYDKQEATNASYRDFRRVTLGVIARAGFSKVMEWVPLATAIANGRDDEGSYQKCLHVLFENFIWAVIAPSWILEMLPFKALREAGGAANDFRFFMNEWFEERKTKIELDNKTTLGPSSGADLMESLVRSSGLDKGSTLEAPLLSKSEVIGNAFVQALPFSLQHLANSPQIFILAGHETSAHTIANAIYFLAMYPEYQVKLQEEVDSILGDSDHNQTSYEAHFDAFSSGWIAAIMCETLRLLPGVATTARQIGPTPRTFPRAGGQRPVTLPPDIEIWIQMIGLSHNPKYWTQPGKTESQSAISEFRPERWLPKSGDNTMFKPYNGSYIPFSIGARGCLGKKFTHVEFTATMLGLFREMSVEFDSCGGRKTFEEARRECLAQMENFESKITLQPTGKMPRIKWVKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR66</accession>
    <name>A0A2T6ZR66_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1049295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000134">
        <property type="protein sequence ID" value="PUU77967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR66"/>
    <dbReference type="OrthoDB" id="5405951at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015638007" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30075" checksum="B034120596DBB057" modified="2018-07-18" version="1">MMELQFKLAAGILCLISLISSLTSGAGVVLQPRDTDVDFSGMPECSSKICIPTLGSSLGCGSGVTLSCFCGKPNPLACAWVVNWDCWNRTEDWFDTQCPGKPLVDLTGIPSCARSCFDKSNVCMEFTSNCVCSQPRPDCSASTTTCNTSEVALYDAWYSKSCEYNLTEAKDSNPSTTKSLSSTASTSASTSTSSPTITTTSNSSSGGLSKGAVVGVAIGAFGGTIALGALLYFLFFGKPKNSEPEYRAAPLGTAEMEDSSHPKIRSELMSNEVHSVPPVEAPGDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZR89</accession>
    <name>A0A2T6ZR89_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1127466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000133">
        <property type="protein sequence ID" value="PUU77986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZR89"/>
    <dbReference type="STRING" id="42251.A0A2T6ZR89"/>
    <dbReference type="OrthoDB" id="4507199at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046623">
        <property type="entry name" value="DUF6536"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35395:SF1">
        <property type="entry name" value="DUF6536 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20163">
        <property type="entry name" value="DUF6536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6536" evidence="2">
        <location>
            <begin position="22"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="688" mass="77153" checksum="42E8BCF67EB5C845" modified="2018-07-18" version="1">MAAVSRSDNNCDSGKPVWYTGWHTGVLACATCVVVVLFINVGFTIYATTNPEHKVEGSIGTLYEGSCDQSKKIGLWLHLVINAHSTLLLSGSNYTQQCLAAPTRSEIDPAHAKRWWMDIGVQNVRNLFLIKPERMLLWMAIGLTSIPLHLLYNSAVLTSLGVNSFVVTVVTSDHFEPGAYSNLTGVIPYWGESRNVSSALESYNASTSTYKDLNPSECIKLYNTDYVSSYRNLFLITQHSSNSTHNNTLLDMIYVIGYGTSSNSWLCSYCRADDIHFYQVPREPCNPSQLISNVTSGLPWSIRLTTGEEVEIGGCKSERAAEKCKVLFSLKIMIIVICCNFVKACCMVIAVIRSREPTLVTLGDAVDYFLRVPDPTTMGICFADRQFIESEWRHGWRTEPRQWKQRRETIDESTVRFPRFQEILCNFLFLIILIAAGVSLRLGIDHEGQYWNTGIKSMWNRGFGKVNSISQIDVYPISITEAILLVNLPQTILSFLYLTHNSLFTCMLMGHEWSLFSHSHHTLRITSPGPGQRSTYWLQMPYTYAIPLMTLSALLHWLTSQSLFLVLIEMWQPFKDEAIPAWPVLGYSCIAIIFVLMLGILALVTAAWVRFKQFPAEITTVGSCSAAISAACHASEAHPEEIVGKKLRWGDVGSEPYLGIRHLTFSSEEGVRKPVFGETYLGNGREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRJ8</accession>
    <name>A0A2T6ZRJ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1084812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000129">
        <property type="protein sequence ID" value="PUU78112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRJ8"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="12490" checksum="F1BA3A8CF55AD70A" modified="2018-07-18" version="1">MFLLRGPALTETRILTHSTIVRSRHSIQGTFAILAVLFLDGTAQIIATFFDFVLFVGYLTSARLPRHNFHRHSRENPLRDSLINIRTSHGINGREDRNGGLVRLVVGLVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRZ4</accession>
    <name>A0A2T6ZRZ4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoglobin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1065197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000126">
        <property type="protein sequence ID" value="PUU78237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRZ4"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="257" mass="28384" checksum="574CF28184EE3DE1" modified="2018-07-18" version="1">MQSIDPKSLSTLQTRITYLKSFTNFTEADAAALHAARPVVEALIPTIVDAVYKKLLSYDITAKAFVPRQTGYDGVAPTKVEELDLEHPMVKFRMGFLKGYLQKLVVMDYNDSRTWEYFDKVGIMHTGVAGFAHRAKKPGLRVEYIHMGLLLGYVVDLVIGAVTAHPDLDNETKSAVLRALNKVIWIQNDCQFPFLVLSGIAANEVVVFARHYVVDLDTPNSVVVPKKGLSEGWVGQIATGAVVAVGVLGVQLILRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS03</accession>
    <name>A0A2T6ZS03_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1084378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000125">
        <property type="protein sequence ID" value="PUU78268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS03"/>
    <dbReference type="STRING" id="42251.A0A2T6ZS03"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="219"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="293"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="350" mass="39477" checksum="84EA700370C013F0" modified="2018-07-18" version="1">MSEPGSSLPPRPPSPVRPSSYLRPQKPRPPPEPVDIVDREQAEGLRAIREFLKVRTTYDVLPVSFRLVILDTSLLVQKSLNILILNGIVSAPLWNSQTSTFAGLLTSSDYINVIQYYWQYPEKFEEIEGFRLDSLREVERAIGVTPIETVSVHPMIQLYDACRQMLRSRARRIPLIDVDEETQQEMVVSVLTQFRILKFVAVNVRETQMLRKPLSDLNMGTYEGISTATMQTPVISVIHQLVGKDISSVPIVDSNGVLLNIYESVDVLTLIKGGSYDDLNLSVGEALLKRPDDFSGIHTCSPQDRLDTIFDTIRRSRVHRLMIVDSSGRLKGVLTLSDILQYLLLDGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSL4</accession>
    <name>A0A2T6ZSL4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1193298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSL4"/>
    <dbReference type="OrthoDB" id="5314674at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="91" mass="10111" checksum="347333C8BE6045F1" modified="2018-07-18" version="1">MLRRPIANTLRSSPSLLLRATAQQARLPDERPSPQSTEQKHALNVQSEQSQYGMTETHGQKTELEENAPGSMPFVYPPTWNSFGAFVGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSP2</accession>
    <name>A0A2T6ZSP2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1114883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000117">
        <property type="protein sequence ID" value="PUU78512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSP2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSP2"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF0">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU78512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="138" mass="15377" checksum="4FBE1F501943CF54" modified="2018-07-18" version="1">MASKPPHQSTAPPLPPNQTLYLQNLNDKIRKPDLRTELYTLFSTYGVVLDVNALKTMKGRGQAHITFRDVAAATQAMRALQGFEFFGKEMRISYAKGKSHAISKLDGTYRVGAAAGVKRQRDEESDEGEEMDVEDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT80</accession>
    <name>A0A2T6ZT80_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1064857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000110">
        <property type="protein sequence ID" value="PUU78677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT80"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT80"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="270"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="399" mass="45629" checksum="900EF7E13B869007" modified="2018-07-18" version="1">MTTPPPLSTAAPNRYKKPNYHLLHALPLPLSVTPLPPLIPHNPLSLVHIIIAYLFPSNLSHPPSLHRGFFHASTRSVHITDQETIRAFWNHGFFGKGNLSRSEPTWVTRRRRALGVIGRDEALTAEEVTERRRGERKEFKKERARLEKEKRNRQLAEEGKLTLEGNEDQEGAASASSSSTARTVHFAPLEPPSSRRRSLERPVADVEDIEHLQLTLEEAFFLSFGLGVLELTDADTNKKIPQKDILQLFRGHMHFPPQSPQSSFEPDDPFMLSYVVYHHFRSLGWVVKPGVKFAVDYLLYNRGPVFSHAEFGVLILPAYSHPHWANDKSRKEGKELRPWHWLHSINRVSSQVKKTVILVFVEVPPPLDDDKEIGVVGLLARYSVREVALRRWLVSRNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTA8</accession>
    <name>A0A2T6ZTA8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_981738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000109">
        <property type="protein sequence ID" value="PUU78715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTA8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTA8"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU78715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="173" mass="19040" checksum="827836D86E093C72" modified="2018-07-18" version="1">MDFAPYQSESPEASRNFIRPTSPPARSSYSPLPAPQVPPPILPTHSSPSGWGSGGVGRETINQFETSLPIRLDWEAVMAYVLLPPAGGVLLLILEHKSDYVRFHAWQSSLLFAFLVILHLIFSFSAFLSYSLLVLDLGLIGYLGFHAYVDADTLDRCEVPFFGPLASSILDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTJ0</accession>
    <name>A0A2T6ZTJ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1064796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000107">
        <property type="protein sequence ID" value="PUU78783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTJ0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="168" mass="18739" checksum="36825D4B29C71435" modified="2018-07-18" version="1">MTTAVVPSAETDSAGSAEIAPRFTKPSEAQGGSGGPSKNLRKRVGGGEDDDESTPIKKPKLLNKGFASYGIQRPYYILSGQDDQDDVMIDLKDKIYRISKAFVECEKYPAGPKIAEECCRSLAHPMPIHILEVFVQAYMTKMWVERKVRAFLSHLFNLRYESTNTPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTY0</accession>
    <name>A0A2T6ZTY0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1083032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000104">
        <property type="protein sequence ID" value="PUU78925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTY0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTY0"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="130"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33187" checksum="F75F5E4615A8847F" modified="2018-07-18" version="1" fragment="single">NPDPPESYTEQQAAINMQKRTPARNIHIYDANDTGIVLGGLVLTNGVTTANFYSMVEIVCLFDQDYTLRDESGITVGRDDHPLQPGKYFIVTAGSITVSDGTWLVRAAPVSTSPYPEEFRHAIREGDRGCVTTGKGACGAAAAYVFPLAYEHHWVKHNYGDWITLQPESRRSINSVQNGLLHWKDLRIHFNSYMVSINPDDNYKIVCFIYDDNGIAGTHLDKTFVEDPKRPVDQVLRWHFRQAVLADMRGQGAPVFECDFPSNSDILDDIMSSSKVGERMEFELFTRLAGYRICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU73</accession>
    <name>A0A2T6ZU73_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B9Z19DRAFT_1125653</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU73"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU73"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="50"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PUU79041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="377" mass="40809" checksum="8019A216A39EBB71" modified="2018-07-18" version="1">MSAVRCLFKGLSFARPASQTRSLLIQGNRFYSDNKVAQFKGTKNANGNYTVTFIEGDGIGPEISKSIKDIFSAAQTPIEWESVDVTPILKDGKTTIPDAAISSVKKNLVALKGPLATPIGKGHVSLNLTLRRTFNLFANVRPCRSIAGYKTAYDDVNTILIRENTEGEYSGIEHEVVEGVVQSIKLITREASERVLRFAFQHAEAIGQKKVRAVHKATIMKMSDGLFLSTAREVAKDFPQIEFSEELLDNMTTNPNLYRDILLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKDLANPTALLLSSVMMLQHMGLNGYASNIQKAIFDTLAEGQVLTMDLGGSATRSQFTEAVVSKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUV6</accession>
    <name>A0A2T6ZUV6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B9Z19DRAFT_979988</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUV6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUV6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015371179" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="25"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="562"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PUU79279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="626" mass="69565" checksum="EAC727F973D90F70" modified="2018-07-18" version="1">MRLAASSLLLGAAASLFSSATALAARRSDGSKSSADYFVRSLPGQPPGPLVKMHAGHIEVDHVSNGNLFFWHFQNKHIANRQRTVIWLNGGPGCSSMDGALMEVGPYRLKDDHTLRENEGSWHEFANVLFVDQPVGTGFSYVNSDSYLTELTQMSDHFIKFLTRFFELFPEYESDDIYLSGESYAGQHIPYIADAILNRNANAAIKWNVKGLLIGNGWIDPSNQYLSYLPFAYESGIVEKGSPIADQIEKQVAVCVKTIAEKGRHHVDLGQCEQILQDILEKTRHHKDGKEVCWNMYDVRLEDTYPSCGMNWPPDLSSLTPYLRRKDVLEALHVNPDKRTGWTECAGAVSSSFRALKSKPSVELLPNLLKEMPILLFSGDKDLICNHIGTEELVHNMEWNGGKGFELAGAPGTWAPREDWVFEGEPAGIYQSARNLTYVLIYNSSHMVPFDFPRRTRDMLDRFMEVDIGKIGGTPADSVIGGEKAPITSVGGTPNSTAAAEKEKERVDRARWAAYYRSGEVALVLVASAAAIWGIFIWKQRHRRGDRKGAYAGLGGMKITGGSRDRLADGRESFDEDELRDLTIESPMFERDRDLEAAEAGRYSLDGASDGESDDEGRAEKRPNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUX2</accession>
    <name>A0A2T6ZUX2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HotDog domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1100903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000095">
        <property type="protein sequence ID" value="PUU79292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUX2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUX2"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="200"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="331" mass="36221" checksum="B518FBB22357FB1F" modified="2018-07-18" version="1">MTDSYHKIILPFSEDEWLVDSYVNASGQLRLGSLFQDLDALAGVVAYKHTGPGTANVTAAVDRISIINPLEDFCNLELSGFVSYVGNSSMEISIEARKAGYPGDGGLLLTCAFTMVALSPQTKRPTQVSPLIVETPEEESIYRRGEAHKAAKKALAKASLTAQTPTPEESLLIHTTYLTHLQYTDPKNPLPKPETTIYMSETSISSTAIMQPQHRNRHSYAIFGGYLLKETMELAFCCCSAFAHSRPTFLSLDPSTFDAPVPVGSILYLKATVAYTEHWKEGSRVQVSVQSSVRNVAHGSLAETGVFNYTFFVGRKVEVMPVTYSEFGAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV82</accession>
    <name>A0A2T6ZV82_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_979802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000093">
        <property type="protein sequence ID" value="PUU79408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV82"/>
    <dbReference type="OrthoDB" id="10336568at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015494919" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9386" checksum="6C846D743D893DFA" modified="2018-07-18" version="1">MWFVLLISRGAWVTLREHWFHLTQEMGSGVIVSNLTESSRRSRIGSAVIPVRIPCCQVRRSVYARSDCLLGELAGWSPWNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVD8</accession>
    <name>A0A2T6ZVD8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_979621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVD8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVD8"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000046">
        <property type="entry name" value="TBC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="788"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="483"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1090"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1178" mass="128164" checksum="F18DFD249D3F3113" modified="2018-07-18" version="1">MELNSGPCKGGSPSGSVSETLPADEPSESTPTDSHPSIPSQASSTVDLLETVDERHPLSNTGSDNSDPGSSLAASITNATTKSTSPISQRSIFRPPSDRTSAQQSITSSATSPLHKSLASPITRPAEQNSDPRSALFDDHVASAHVPGSLHLAPDSAIEKLVERQGAITLIRQLASDLAHRDRELVSIRRRAEERERALKKMLVEVEVSNADIEKRLAAATLQRKPSRETVRSAAGDTSYTESIDDMMQQAMSEEDVFSVVDDSLSMMEATTDLGDDDQHSTRDDMVTPKATLRARSDSKSILFERDTDSMSIISNTSSRRGSTIRGWKSFFWGQKIGESDENSVRNERLVLQSPPPGKRRGITDETFSPPPEGKPRILSRASSPAVSMIQPGSHPDALVQRGTSNAVADWAMRLVSHAPPLYEQENYNPKSPAQPRSASATEGFGVPADRRGSSGSIDRENLQRIMAKNAARTQTSPRRRAASAAASSAAPPKSSKFFQDIIDHAERIVPLGHSSQNASSADPSSGPVEMDRIVPHAIQPPTLLQSWNDYYPTDYLTDRFGFIYDRKSKALSAKSMSSVGGDGAKKPQHQDAKSEPTLNEEDSSDASDGPDPGLLDTGDTRTPTTWQELPSEMPSTSLHQSKTSKEAPAGASENSQHGQPAKSLIDRIAGSTSAVASPTTTTFSEAPLALRSPLHSEMSSIAEAGTVQLLLGQLSDLHDSLQRDRGAKWNEFLKKIRQERRRGEEEEKGMPEVLMGDGELIGIATLGNEGRGGKQRWKEFKGLVLGGIPVAYRWKVWAECSGATAMRVPGYYEDILENSFDDPLVIGQIEMDINRTLTDNVFYRQGPGVSKLKQVLVAYSRRNSDVGYCQGMNMIAASLLLIMPSEEDAFWVLCSIVEKILPKTYFESNLLASRADQQVLKQYVQEVLPSLHMHLQKLGVELEALTFQWFLSIFTDCLAAEALFRIWDVILCLAGSPFLFQVALALLRLNEKALISCKSAAAVYSYLNGEMTHQGISIDGLIRESDGMKHHVKKKEVELRRERAVEKELGEMTPEDNGNVTEATKTGLPIRAVANSSDEESQEPSTKSIHNEEKDRNGVDKTKGQAAGGAEAEPSSCVIQEETAEELLAEDAKPFVDTIEHVANEDQKSGAILSPPLDKPITSIPMEVSAIPIVATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVG8</accession>
    <name>A0A2T6ZVG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1081597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000090">
        <property type="protein sequence ID" value="PUU79491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVG8"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="128" mass="14090" checksum="2260B4B97F1D8F36" modified="2018-07-18" version="1">MAYTSGYGFGGNELSPDSRTQLSQPRHPYTPVDTSESSISPKPETNLAIGLNDKNLNKPWRPFTLRAPTIIASLIIAVALIALVEYINKISIQEKALFFAERAEDFPMGVVFCYRYLPQTIVVALGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVH2</accession>
    <name>A0A2T6ZVH2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="3 21">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B9Z19DRAFT_979619</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="21">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="21">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3 21"/>
    <dbReference type="EMBL" id="NESQ01000092">
        <property type="protein sequence ID" value="PUU79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVH2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVH2"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.270:FF:000002">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12 21" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="24">
        <location>
            <begin position="136"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PUU79424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="233" mass="25349" checksum="5BA338A6115BE589" modified="2018-07-18" version="1">MNCLRTTAARALRPRTIAPLTTARYANGASTSHFDDTSEYKSPFASPEPRTTTKIPDFSKYRGGSTSGNKLFGYFMVGTMGALSAAGAKATIQDFLVNMSASADVLAMAKVEVNLSAIPEGKNVIIKWRGKPVFIRHRTPDEIEEANAVKVESLRDPQTDAERVKQPEWLVMVGVCTHLGCVPVGEAGDYGGWFCPCHGSHYDISGRVRRGPAPLNLEIPEYDFPEEGKLIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVK2</accession>
    <name>A0A2T6ZVK2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1081464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000089">
        <property type="protein sequence ID" value="PUU79519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVK2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="76" mass="8166" checksum="38240A0A12C4E3B6" modified="2018-07-18" version="1">MYTVLYKNYTLTLLPLTLLALSMAMAITLAVVSFRFMPFSQALMSTMPLSVVALGCGFMMGCFVEGRGGTGERGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVU2</accession>
    <name>A0A2T6ZVU2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1081296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000086">
        <property type="protein sequence ID" value="PUU79621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVU2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVU2"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF87">
        <property type="entry name" value="TBC1 DOMAIN CONTAINING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="443" mass="48751" checksum="964067C564C8EBEB" modified="2018-07-18" version="1">MEYFKEGDLSRHTSTPLPQETVQDISKQILEGLKVMHQHGIAHRDLKPANVFVVSMSPVWVKLGDFGVSKRIRAQATTTFHTQVLTQAYSAPEVLGLDSNSETSDYTNSVDIWSLGCVIYELLVGKQLFVSEAQVSRYFFGKKPFPKDKLKSLSPPTDNLGISLLKSLLVIQPEDRPTAAGALSHGWLAGLKTGDEHSTGDQDETTQSRGETASGRKRKIGLATHDRKKKRRSRRNSITLDGTKCSPVGVASEANAGSQCGGVQTALREPVANTCVTTPSDAASVRSSPELAPHNSQAGHSIRLKPPRKEKIRNIPHTLTENHLQVIPRRQTFVVEIISHPPRRQMGAMEHAPRKTRKFRNSTPDETVARITIGEPTLPCITDPCKTVPKIQSTKRNTRGAGDGRNKNALTMNSIRSQNTTWSPNTRQDPYTKQTPIAGRNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVV2</accession>
    <name>A0A2T6ZVV2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1081349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000087">
        <property type="protein sequence ID" value="PUU79602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVV2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZVV2"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="116" mass="12538" checksum="4A63B78BA6733110" modified="2018-07-18" version="1" fragment="single">RPQCNSRDFRQVRGQGGYQLREDSDKRIALFGGLDVIVSNAGWTKISDFGDPSALSEAEWDKCWAVNVKANLHLLRAASEYFNANPDGGSFLISSSTAAITPSAAGLHLMPCLAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZVW1</accession>
    <name>A0A2T6ZVW1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_810277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000086">
        <property type="protein sequence ID" value="PUU79613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZVW1"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU79613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="252" mass="27664" checksum="735B1656191FD5CE" modified="2018-07-18" version="1">MEYLSGSFFDEAAAGLILSSHHQPQEYNLYSHSAYIEDSLLPSPQSPPPSSLTPAASPGALFLDDLFADIDTTPIDSKDLMEFFSDLPFAHPIPPTLPPSPPHSTPSTSSRLSSTPTPPPASPPPATPKPRPRQRKPRKDITYGCTSSTCAFPSHTPPIPSANHHHHIADDPMHKKRLCCRFPECNVCPGFVTRKDRDRHEVSKHKPGQRFSCSVCGLEMARLDNMRVHVRSAHPGLTEEGVSSNIRRKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZW49</accession>
    <name>A0A2T6ZW49_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1081125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000084">
        <property type="protein sequence ID" value="PUU79713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZW49"/>
    <dbReference type="STRING" id="42251.A0A2T6ZW49"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU79713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="113" mass="12142" checksum="10EDB27E056ABBED" modified="2018-07-18" version="1" fragment="single">MAINTGSETQEIFLNTLDVEEFVDFVKGDVVANVTSMARGLGAHAATLLTVSEKPSQQATEYCRARGTIVCLGLSPKVHISAEVFSTGSYVGNRLDTKEAIDFFARCLTKAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWJ1</accession>
    <name>A0A2T6ZWJ1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1174696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000082">
        <property type="protein sequence ID" value="PUU79804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWJ1"/>
    <dbReference type="OrthoDB" id="5424344at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015648745" evidence="2">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU79804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="241" mass="26660" checksum="23FE0CCC5D6491D6" modified="2018-07-18" version="1">MHTPITLLLLLLLGTLALTTTITTTSQTLGHPPAGQPPPPPPQNLTKTYEPNHLTNFITNKLSTPRKWMLKKPPGAPPPQPPRPIAPSTNLRPPYTDPIKLQRFIQDLRATRRPNPLRRRGIKSNSESLPLPPPPPRPAVKEEEGEEEEAVEAVMPKELTEAEFDAMFEEYRRRHDIAVGAFPKELGPEKFGGGGTECGGFIERVWGRRGGGVLGKCRRKAGRGGDERRPIARPAIRPTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXE8</accession>
    <name>A0A2T6ZXE8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_950657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXE8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXE8"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="60" mass="7070" checksum="E698E461DC8DE90D" modified="2018-07-18" version="1" fragment="single">VASKYLDLTTQKFDIARLPNDFGQPEGEEWADGTPKRVVEELIDHWQEHFDWRKQEAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXJ2</accession>
    <name>A0A2T6ZXJ2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1080122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXJ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXJ2"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="87"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="288" mass="31671" checksum="883A63E5139CE563" modified="2018-07-18" version="1">MCIKVGYVPEHFSTPLHFAEAHGFFTSRSLPITLIPFPSGTGHMIKSLSSGEISIAIGLTEGWISAIANGNSDFKIAGKYVATPLCWAISTGTQQGIDRVEKLAGGKLGVSRIGSGSYVMGFVLAQVNGWLKEGEEPFEFVILDDFKGLRDGVNSGRADAFMWEYYTSKKYYDSNEIKKLGEIYTPWPSWHIVASNNLPTTTVGQFLEAVNQGITYFNTHKDEAVEYISTHLDYSKEDAQEWLGTVEFAGDVREIDENDINETLKVLRGAGVVKDSKAGYQDVVLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXR0</accession>
    <name>A0A2T6ZXR0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_975351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000068">
        <property type="protein sequence ID" value="PUU80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXR0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXR0"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="310" mass="33041" checksum="62BAF9A36C47C461" modified="2018-07-18" version="1">MSSTTVHVSNISHNTSQQEVRDFFSFCGKITNLVLTPSSSDPDATLSATVTYEREPAAKTALLLDGTKLGSNPVHVETTHSIDEIAQGHLARGDADQDPPKDVQQEDKPKTAILAEYLSHGYAIGDSALQKGIEVDSKHGISSRFLSTLNSALQTIDSRVHATNTARSVDTQYHVSDRALGAKNTLTTYFEKALGTPTGQRIRTFYEQGGQSLMDIHNEARRLAELRKQQNRKSADGGTLAESEKTTCACAGNAGVCTCEAGKCACAGCGMGEKGTKGDSAQYQSGESARDVADTTKDLGTGSKEKSTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY01</accession>
    <name>A0A2T6ZY01_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_738385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY01"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="135" mass="15732" checksum="0CC938BEE32840E8" modified="2018-07-18" version="1">MIWFFFSSLFLLFSFSFPFFSLIPFCYRIPLDPRARGPPPLQPTKHTACFMVWGLVDDVPKHRMGVCFWKREARFLFLLLLWYGTALDEYSTFPLPPETQAKSDDPNPITPYASGSTLFAVKPIMITKKKKKVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYA0</accession>
    <name>A0A2T6ZYA0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1123565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYA0"/>
    <dbReference type="OrthoDB" id="5414590at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="269" mass="29127" checksum="4A13E6BF2B26AE3E" modified="2018-07-18" version="1">MTARQSKPTAVAKQSRPLQILVYTPESGGAKGAPQTSEIFDVSRSGSSSKDGAGGSRILEFTNGNGEALRIPEYTTHTIRYSPPSTLGRAEGQYHRPIATTPAAPIYPHHHRQYPDRFLQLYLSHQEPSPSLPPPPPPPYPPFIPPTPQQSPEFATTTMAIPPISDEEWAMLTSPEFPPEEMLGLNPGPPAVTEELLEACLPVDSTDEGRQWWHELLCAGDEQGFWTRFLASDERALGGEAGWGGNGVGEEMQGGYGGELESGPGGWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYV2</accession>
    <name>A0A2T6ZYV2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exocyst complex component Sec10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1100167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYV2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYV2"/>
    <dbReference type="OrthoDB" id="5554140at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF1">
        <property type="entry name" value="RECYCLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="911" mass="101775" checksum="B7AF424217F3D6E8" modified="2018-07-18" version="1">MLMLGLRLEIISTILEYLPIRDLCSFARVSKQLQEMVYDDSRWVHKLKLMGIWNETEARRRFEDAMRRRRAVQAARAAEEGKKALENGVKTPNVGLAGGSPAPGVSRSSTLFDAGEEENRVQVQREASMRRAELDAKRRTVAGTITEGIDFMNPAPLTPIDIPRPGIADPSSLLKVLPSIKSIRGFARHEFGRIYAALGPLYFDLAKAKTHTDPVVFRIYRDPEQQAQILAQLKVFALCDTAHGWMDRLERLDLMIGIFENAALREFEGGYETGDTDGRMRRYANVLILLNGGQACVQLFVQKHPVMFERGELGNPMDSFDKPMPGSFSLEPSSLFFTRLSALLHEQADVIDRVFPATVNVMIPFLERVAEDVISEFVTPILDEAHDRDIEQYLKAVAGIYHQLLEFAKTIKATNGSGEKFPEEVMKIMGRVFEAHVDLYLQDELEYFRKKCEAEVDSWEKKILEEDAATESFFMSNINREADKRDFLSTFKKVILMPVSAIPSPFSAKSASATETKPAETSPDASSNSLSVQETPNVSRPGTPVVPGQAAPGPPPTTELAAKAAIMNSRLEGIRSLFSLEVALNLVHSAKSSLERAALFASAGGQTGEEAREQCEQIFIALLQVLGPRHVKAGFDKAVEHLSKYNPREITEHSQPGVPPLVTFLELVNVGDLIQQMIDVFYEQELVAAKLTDPRDFLNPAAKEKKRFEQMLDERVAAGLNMGIDVLIDEVDHLFAITQQTTDFNPGAIGDAGLRDFDIGPTKTAIQVIEVVSSHTKLLTGSIDKNVLDVFNQEVGIRLFASLCKHIKRQRISVDGAIKLISDLNHYHAYIATLKIKPLVPYFNALRELSQIYLIDPSHAKQMATVIADPNRFGGIFRVEEVYEYATRREDWYRVKKEVERAMYGIGCCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZ49</accession>
    <name>A0A2T6ZZ49_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1191600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000057">
        <property type="protein sequence ID" value="PUU80767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZ49"/>
    <dbReference type="OrthoDB" id="5397976at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="294" mass="32923" checksum="C3BD311E84886884" modified="2018-07-18" version="1">MHHLHRTPSTSHPTSATTPARSHRRTLSTSVRTPGSTIRPLRASLSYQLPPNFNQSRIHPRVSLSRPPTTTLRSTARRQPPRSSLPHSFSLPFIQAQARAEPQPRQPSRWDAPPIQPPQRLLPLLQILPSEEQELEELACKYVSKRMPMGYWAGRFGSLIDRMCAERPGDWEDERARRAFIVLEGELDETVDSGSGAITADIKSALSHAPIQRVIDLRRDLAWTQVLGVILPHLLLAHAHLMRKGVGLLSPGATYAREVLCRAVRVSVAGAFRTTLNVRKTFSYYGLLQVQLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZH5</accession>
    <name>A0A2T6ZZH5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1078368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000054">
        <property type="protein sequence ID" value="PUU80899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZH5"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015592832" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12627" checksum="57445430A89B7D32" modified="2018-07-18" version="1">MRIKRWFLLLERLWIYHISFVLSRLGACSFPLIAEKGNSNVLSYRCSTFIFHLSSTVPSQELRPKPEWERGNLVRDRLPNRSGDLLFTVPIGFLGPANFQYAWRVDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZK8</accession>
    <name>A0A2T6ZZK8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1122701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZK8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZK8"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000085">
        <property type="entry name" value="Putative ras-related protein rab-11a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU80911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="212" mass="23594" checksum="D12ACCA64F21762E" modified="2018-07-18" version="1">MANDEYDFLFKVVLIGDSGVGKSNLLSRFTRNEFNLDSKSTIGVEFATRSIQVDTKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKQITYDNVTRWLKELRDHADNNIVIMLVGNKSDLRHLRAVPTEDSKNFAAENHLSFIETSALDSTNVELAFQTILTEIYRIVSSKALDGGDQHQVSQPGSSQPLHITPTAENATKDGKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZY2</accession>
    <name>A0A2T6ZZY2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA replication regulator SLD3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1078023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000052">
        <property type="protein sequence ID" value="PUU81021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZY2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZZY2"/>
    <dbReference type="OrthoDB" id="5395343at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="228"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="511"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="828" mass="90846" checksum="078DDA28DD8F6FDD" modified="2018-07-18" version="1">MEPSVLGTVPSSNTVPTPSSSRKRKREGEKVVLGDSFVIGPYSSSVFDSSLKLTPAVALPRSFIPLQWLAGTPSRLFSFANNLPVLEVPGNILVAKVDGERQLAAVEKVQDGVYAVFKLSTQLKMRDVRKTVALARKAPREPLNLEFDKVGDGRLGGEWWSHLRISDCTVKGLLSSPDPVGTLTMGSPDSEPLRGNQTSLQTPTRLPIPPSPAVEALTEEFASPTLSDILGNARKQYFQTLYIAKTSLAYFAKSTLSRARVAVRGDSSELPAAPGGELIAFLQTMLLPFEKMDIKFRSVIPRIALEEKVQENEVLRAGEEEYVQEWRSAAFQDKLVQASDQWLKRRVEELKIRETELQIILLLEIMSLQRDQVTPTDENLIKERTSRKNKKSSKRKGKNKTRTDAPDYSLLLDLLVDRLCIWRSIGSISEGPEEESTEQKLVMDKEHDHLRHFCVEVVLALYNYRIFCSGDDKLTVESYASKLPEECKSINKKCGGRSGSSSARGNRDASTSNKDKRKLAKKTPGFTRSITAPAATNATREASVDTLAALVAADAASVSKTNIRGGTLNSKSFVKRQVQISSKVVQKKKVDEELKDAINALKKPNRIAVAADIVEDAKKRLAAGSNRRPRKVPGGPLANIQVMATPKRRRTIKPQLNLPPLLEDEGDAAPQDDFLPEVTYPKAQFEVASTPVRPLQEQRMMGEDGVPSTSPFEVLEENAPRPPLGFAKNMFVTPKKKSRSMGTDLGAGNSIVLATPKNNNSGLSRSLSCSVLGSKPAQTPESSPDGGVKLFGSIRETPVKRTLQVGASGGDEEISIYDSLGWNDDYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0C5</accession>
    <name>A0A2T7A0C5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_894533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000049">
        <property type="protein sequence ID" value="PUU81145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0C5"/>
    <dbReference type="STRING" id="42251.A0A2T7A0C5"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU81145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="11722" checksum="C0EC610A5B4B670F" modified="2018-07-18" version="1" fragment="single">ITPKFDVRELPNAYILEGEFPGIDDTSSLCIEFTDERTLLIHGRLERAVTVAGEEEEERGSYLIMERSVGVFQRRFWFEEGVEVDGVDASLGNGILRIYVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0X3</accession>
    <name>A0A2T7A0X3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_617002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0X3"/>
    <dbReference type="STRING" id="42251.A0A2T7A0X3"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="616"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="565"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU81379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="719" mass="78848" checksum="E68D7D4C7C6B838A" modified="2018-07-18" version="1">MVSAVQAGGQAGHRRMSSLRSTTLNFFKGNNKGSQLQHSTSLRRNELTINSQLPIMEENVSPTAIGPPSRADTEPTLSEKTMSRHHFSSTGVFEVGFGRGPPLLPAPKRESSSAGGDDEDGNGSTITIGMDAREMSPSRQSEFDNMEEKLGSTTTQSARSKKRGQKLKMALSLLRRRSNTNLRRAYGDSVDGNSETSRDRETFFEPLLDPDYIEPAPSPTRATPTPPGPLNQPKTNGFKFALTPRSHARQVLTKAPPQPPPDNRRPRRATVASVIFDPPGDPEHSRNSMWLDRPSSGQSGILKGMPQDEGGMSNGSFVNPDGILVNGTVAPGGGLFPRPASLQRHWSDGAQNNHGTVSVVDRSGMSTPCLDQEPVRPLSFGAMLNGYGGSMKITEAVSLETRVQELETQVATLQNFITQHVEFPLQPRRTFSTGAPTNRDNRDRELLLRPPTDDRKFSKRSYSLSSAGSSEKLGSPELPSTPRNLYPPPRSADQRVPQYSPRTEQEHEETLQALEGFRVNTESKRNTASTIKGPTLMRDDLIETRSPSPTPIVSMAQYTGLVSQVKREQRARRKLEAQIANLQEQMSLVLHRQLLQSSASPTIADALSLRPGDFSSVRRKTSSEVPTPDLTPPRASPVSHLFTGFDSSMVDDDDSDGESVFMGIDADDNEIWETPAEERESMISDSDSDRGFRETLSAFPNPQRTLSLSQLTHKSSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1N6</accession>
    <name>A0A2T7A1N6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiamine pyrophosphate enzyme, N-terminal TPP binding domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1019236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1N6"/>
    <dbReference type="STRING" id="42251.A0A2T7A1N6"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="209"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="416"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU81648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="577" mass="62271" checksum="F5C53337BB3E3BC6" modified="2018-07-18" version="1">MYTASFAFFEALWEAGVTHCFVNLGSDHPSILEAMVKGKRERPHSFPEFLTCPNEMVALSAAHGMAQVTGKPQAVIVHVDVGTQGLGAAVHNASCSRVPVLIFAGLSPFTQEGELRGSRTEFIHYIQDVPDQKAIVAQYCRYSAEIRTGKNIKQMINRALSFAMSDPKGPVYLTAAREVLEEDIEPYSLNQAVWDPIGPTALTEEAVSTISESLLSSENPLVITGYAGRNKDAVQELITLADSVPGLRVLDTLGSDMCFPANHRSSLGVMYGVHEKITTADVILVIDCDVPWIPTQCKPSPRATVYHIDIDPLKQQMPLFYIDADARYRADAYTALKQINSHTTGMRMDAATRDARIQVLDDEHKARMARLEQQAKPRDDGLLSCAHVMNVLRGAIPQNSVIILEAVTQTVTVVDQMKCSLPKTIFNSGAGGLGWFGGAALGAKLALDNGTPNSGPFVVAIVGDGTFLFSVPASVYWISRRYKIPFLTIVINNEGWNAPLRSAKLVHPNGLSAHATHEELNISFKPSPDYAGIAVAAGGGEIWGGKAEKAEQLPSVLGEAVEAVKGGRSAVVEVVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1R9</accession>
    <name>A0A2T7A1R9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1076574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000042">
        <property type="protein sequence ID" value="PUU81615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1R9"/>
    <dbReference type="STRING" id="42251.A0A2T7A1R9"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="592"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU81615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="652" mass="74343" checksum="65AA2C7709B6C12B" modified="2018-07-18" version="1">MQLTWKTIAPVPTSQEFLDIVLSRTQRRLPTQIRAGFKISRIRAFYLRKVKFTEQTFSEKLGAILESFPRLADIHPFHSALMNTLYDADHFRIALGQLSTAKHLIEQIARDYVRLIKYAQSLFQCKQLKRAALGRMATITKRLKGSLEYLEQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLKSVTRADVDVQPYAFTTKSLYVGHFDYKYLRFQAIDTPGILDHPLEEMNTIEMQSITAIAHLRSVVLYFVDLSEQCGYTIEAQVQLFHSIKPLFANKIVFLVVNKIDAMRPEDLDPARQELLGTITKSGEVEMLKLSCHTEEGVMDVRNQACERLLASRVEQKLKNVMSSAAGKEVTDILNRIHVSRPIGEGLQPFIPDAVLNRKRYDKEDPQRRKLERDIEAEEGGAGVYNVNLKKNYLLENPDWKMDKIPEIYDGKNVYDFIDPDIEQKLAELEAEEEQLQESGFYDEPEDIEDEEEAEIRTKADYIREQQALIRNAARSRKSTKNRAVIPRSAGQGKKLSDMETHLDKLGLDSSNIVARARSISRGRAAARAAKDTDAMDLDEGSGAKNKMTPIERAKSRARSINRREDGIADESNRTKAEKLAKLQQKRMNRMARQGESDRHVSASLPKHLFSGKRGMGKTHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1U5</accession>
    <name>A0A2T7A1U5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1076464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000041">
        <property type="protein sequence ID" value="PUU81697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1U5"/>
    <dbReference type="OrthoDB" id="5446587at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="248" mass="28244" checksum="2A7BB574372B40EB" modified="2018-07-18" version="1">MVVALVYNEFDGCSDTRKDLSIAKQNSTQAIRSMVPVQIGTSGHVETAYANPDRGSFLKSVREMERNMEKMMARQEVMERELTVLRPIKATAIGIRDRFFASFLESKASAIGNLAVIEEVNKLAHEGDVVTDVCLLKNGMIRYPGTFRRLYGLHWEDASSLLVFPHMVTAMNLRATWIANGGEEGCMQAEFNELQCWSRHATPDQIAIFNADPSGRTHHKLIYLHLKNKLRLTKELRLKLTKELHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A255</accession>
    <name>A0A2T7A255_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1121719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A255"/>
    <dbReference type="OrthoDB" id="10675778at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="491" mass="52710" checksum="FEAEDC0C4A904DB4" modified="2018-07-18" version="1">MYYNGKAYSTTPARATDEEIEDDLAQMRKTWDGKPYVKPALSKEVLPEFDYCGYNGREKAGSSFAKPNEPREPFMKKVVQDSQFKAKEAEPLLDACNAGGEPLAMKEVFQENQLKEKEVESSLASETPTALAPIACAVDAGAPATSRKSKIPEIPDPTNSPLTSSLYGQMRQTENKQGPPHKKLRTTNGAVNRTATQKARYAGGERIKKTARVGIASSVVDKSRAKAAPSVIPAGAKPLPANTEKSAGESAIVSKGLAVVIFTRASSRGIIRKDKSPTAAVRETEDPIHEIVTDKEDKSSTSFESGDDLKKDASYTPVTPRKRRVARKGKAPVASRKRAAPNTAVAPPRRCVRRKAAAPEESITRATTSLGETGTALTKENVKPAVGPREHKEKRVDTPKVRAIVPQQAGPPAAPEVDSTLTAEKSTPTPTTNSVRGEIAVPEEHAPPAAVSETSVGSVEAATPATTSAPPVRVRRLWYRIPAERSRCHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A2C9</accession>
    <name>A0A2T7A2C9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1099516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000037">
        <property type="protein sequence ID" value="PUU81896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A2C9"/>
    <dbReference type="OrthoDB" id="5328813at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU81896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="190" mass="20973" checksum="ED53B3381F64C8D0" modified="2018-07-18" version="1">MALRAVAGHVIQKAFESEEFVGVGEGLGSLERSVGRNIPEAEFNKWRSQTFLIFSKASTAESKAHVVAAISQRIDSLLSPFSTTPDQQERLHFLYRIVESAAALSLDLGCQLAKFKVLSDPAETPFDSAHMEDVYQEHETQVDPHTGKSINALDGKVIQAVVFPSVIKWGDERGENYEETKVILKAKVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A346</accession>
    <name>A0A2T7A346_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific]</fullName>
            <ecNumber evidence="5">2.5.1.87</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_969516</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.87" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000034">
        <property type="protein sequence ID" value="PUU82115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A346"/>
    <dbReference type="STRING" id="42251.A0A2T7A346"/>
    <dbReference type="OrthoDB" id="19639at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038887">
        <property type="entry name" value="Nus1/NgBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21528:SF0">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU82115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="324" mass="36872" checksum="0FECDB690C767E2A" modified="2018-07-18" version="1">MASASPPPPYSSSSSSVNPPRPLKSALRSRQQKPPEVLERERIILAHLPAADLSREKPIRNFLATRFYKFVLLTIHLLFSIYLKLRWAYHNILNRGLSILYYHHRTPQLIQKDVKELEERGKLPGHVSVVLEYERGGLDTLIDEVSEISCWCASAGIKTLSVYEQTGILKSYISTSHRSISQRLHSYFGKSRPSLRVHAPPLSPLREPGEEGREVDLEVIFISEEDGRESLVDLTKTLCDMAQRGKISSEDVSVELIDAEVTENTISEPDLLILFSPSVVLRGYPPWQIRLTEIFHVQDNSGVGYQVFLRALHRFAKTEMRFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3I7</accession>
    <name>A0A2T7A3I7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1041419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000031">
        <property type="protein sequence ID" value="PUU82255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3I7"/>
    <dbReference type="STRING" id="42251.A0A2T7A3I7"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="2">
        <location>
            <begin position="247"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="677" mass="76168" checksum="0BD003CE0EAA4136" modified="2018-07-18" version="1">MSRASTSLGTSDLPDHADSAYRAIEITSTDPVIEAADGHRLSRVPIEEARKSNALGSEEEEEHRRDGNFGPLVGAKGQRSVLSPGLGDAIESKLQGAGERLDITEERDGGEGNTNINKAPAFTNPLFPPLPVYGPPTLLRRLQYTAFRVCSGGLSLCFLFVIVMGAIAKSLPLAFMGLISLVRGRDPNATRPFYEIEKERAKKRRDEIKAWKARRRDSQSAGDQDGERGLRNKQIAGGRDNLVCDIGYYARRVGLDAEEFEVQTEDGFLITMQHIYDPDDPPHYPGENIGEKDDRGRGANGKRKYPVLLMHGLLQSSGAFCVNDEDSLAFYLCKAGFDVWLGNNRCGFKPKHTIFHYFDPRMWAWNIQQMGTIDLPALIDHVLSITRFSKLALICHSQGTTQTFVALAKEQRPDIGSKISVFCALAPAAYAGPLIDKIYFKFMKIISPSMFRMVFGIHAFIPFMMLMHATIPARIYGALGYRVFWFLFGWSDVRWDKGLRDRFFQFAPVFVSAEAMRWWLGRECFARYKCILSTKSEEEGADQEEEDEMRQAKQEGLKMEQTERCGDQGKELSPSPPTNGGPWYDGRCPPMAFWVAGNDDLVDGRRLIKRFERGKEPDVDLVHTKVIEEYEHLDVIWALDAPEKVFKELVDVLWKCVDEDVKREVIVPRGVGELGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A3N1</accession>
    <name>A0A2T7A3N1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1120962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000030">
        <property type="protein sequence ID" value="PUU82329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A3N1"/>
    <dbReference type="STRING" id="42251.A0A2T7A3N1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="487" mass="55362" checksum="EFDFC0AA3C8A4E9C" modified="2018-07-18" version="1">MVGKGEKSGKRGGPGNLGTRVEKKGGGKGGKLLLADRKYRVVGGGEAVLGGCEGDWKVYKGLKRVDGGWENDEVRLEDKMVLDGSEWGISGKGDWDIWEDGMEGVEEEEMNSAEAVEKIIEEMRGVKDGVEIKREEVERKEGNGGNKKNEREEEDGCCEGKKKVKGKETEIIVIEEEEEEGLSSMEKWTMEKKTKEKHEREERKRGEKEGIINRGKDRGIGRDSVMEMWREWQDYEELVKDTRYVLGIRMEEARSFMLDREIRKVLELGLGGGLGGKGLKELGEEEVVVRSEVVVERGLKEKEDLKKEVAVEGGRSYSEVLRGTPEREDEMEELTEKKDVEIKKWLDDSLERERRSGKVVEVVMDSQSGKSEEDWKVDEVMEKLGVSKNAVDKMKVCGNRVKMVMKDREVAEKIEEMGKEVIGEAIGGGVVEVKRNENWVGMVVPGMEVDMWEGKMEELKKKIEEENGIKLMRVPRWLANEDRRRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A4U5</accession>
    <name>A0A2T7A4U5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1074171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000022">
        <property type="protein sequence ID" value="PUU82762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A4U5"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU82762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="464" mass="54388" checksum="B5966F41C33101C3" modified="2018-07-18" version="1">MSTPNGPLQEFFSQFNFHGYTYDPHTPALEEFKFLCQARQWGRRKIREHETALLLAVEREQDLRRSLAGLNMPLQEFFSQFNFYGYTYDPHTPVLEEFGFLCQAWQWGPSMIREQEMAFLIAVERERDLRGSLVGPNVFDFFRKYEFQRFTYNLDAPIQSEFQRLVKLRGWGEANLSKVAQQFNRAVVLDATEQSVLGTQEAGLLAHWLIEQECHGYRYLGGLPEIEFKKLVRVKRWKWNQVRREAGMDTRNEAWKESEEFNQLHTEFYEVVEEAFNLLLDSFCQIARFEPWQVLVGLYGPGLYGPEQGIIGLYGQELESMGKEAAKIILKSVFVNIFDFLDAFQEILRDPPTTDRWMLLQLLRPLAIELQFPNNSLLGVYSALTNRVFPLEIAEKDGTLVLLLHRIRVFWKGFRGLMKDFEEEAGYELQEAEAEGRVGIRRLLLSREWACFHSLRARQQAVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A508</accession>
    <name>A0A2T7A508_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_966436</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="NESQ01000021">
        <property type="protein sequence ID" value="PUU82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A508"/>
    <dbReference type="STRING" id="42251.A0A2T7A508"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="237"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="583"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="760" mass="82348" checksum="5B22A8674BDD7D4B" modified="2018-07-18" version="1">MSNPGPAQPALPTATNVIMIDNYDSFTWNIYQFLTLEGAKVTVYRNDKITLPELIALNPTQIVISPGPGHPTTDSGVSIECIKHFAGKIPILGVCMGQQAIFSAFGGAVEYAGEVVHGKTSLIKHDTKGIYRNIPQDIAVTRYHSLAGTHATLPADLEVTSRTDRDIIMGIRHKEYAIEAVQYHPESILTEEGRMMFRNFLEMTAGTWKGCEVSLNTGSSENTAPNPSGAANSESILDKIYAHRRATVTAQKLLPSQRPADLEVLRSLSINPPLIDFPARLRAVSTPCALMAEIKRASPSKGLIDIDASAAVQARTYALAGAAAISVLTEPEWFKGSIDDLRAARQAVDGMPNRPAILRKEFIFEEYQILEARLAGADTVLLIVKMLSDEELKRLYDYSKSLGMEPLVEVNSREEMERALKVGSTVIGVNNRDLHSFKVDLETTSGLVGMIDKEKVILCALSGISARKDVKRYENEGVGAVLVGEALMRAGKNVKFFIDELLSDSPASTSSLYKHGVLVKICGTRSVEAAKVAVESGADMIGMILAEGTKRTIDLETAKAISDVVRSTPKGGVSDTSIDSKSTANPPQSHPETTAQGWFDHSAKHLIRHPKRSLLVGVFRNQPFSTVLALQQALALDIIQLHGSEPLEWARLLPVPVIRRFSPGEEGLNKSGYHAIPLLDAGIGGTGERVDLGEVENVLAAGTPIMLAGGLNYHNVEEFRAGGLFEKGIIGVDVSSGVETDGRQDLMKIRRFVYRAKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5B8</accession>
    <name>A0A2T7A5B8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1073797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5B8"/>
    <dbReference type="OrthoDB" id="5426144at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU82937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="199" mass="22381" checksum="6737B3109560A9E8" modified="2018-07-18" version="1">MYHPTAHMPSACHRAPNNEEELLEGYKYKEQGDSDSESEWDSSSLLRPNLHLLELRNPSSPTSIPKTRKSSSYAKAQEEISPTALEGLALLLTSTGESSEYGHGGNGEEELAVELQNYMCILNDAADEKWEWEKEKYVCILMKALLGGLGIEGEGVQIDPVGTRKREFCNEGEGVREYGKDKRRRILGDEKYLTGRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5G7</accession>
    <name>A0A2T7A5G7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_934144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000019">
        <property type="protein sequence ID" value="PUU82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5G7"/>
    <dbReference type="STRING" id="42251.A0A2T7A5G7"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="112"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21170" checksum="645BBD814CBD0276" modified="2018-07-18" version="1" fragment="single">SRALGRNVHIYSARDTNTVLGSLFATNGMTNANFYSMVEIAFIFDEGYTLCGESGTNVERDNHPLQAGRYPINTADSLRVNNEPLLVRTGSLSAQAPPKEFLVEVRERDSQCVITGQPVLNAVYAVYGRDGYSATPIYPLAHEQRWLTHGYDSWITIPGARGSISSVQNGMLLRDDISLHFECYHLSINPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5I6</accession>
    <name>A0A2T7A5I6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1073622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000018">
        <property type="protein sequence ID" value="PUU83007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5I6"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU83007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6491" checksum="E2CC7268B7F79A1F" modified="2018-07-18" version="1">MVRHPELLTCFLHGASIVQHNSSKKIVHTGIICLMLDVLVQHMTGHSGWPQYEALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A5Y5</accession>
    <name>A0A2T7A5Y5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B9Z19DRAFT_1061269</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="NESQ01000017">
        <property type="protein sequence ID" value="PUU83128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A5Y5"/>
    <dbReference type="STRING" id="42251.A0A2T7A5Y5"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="51"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PUU83128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="737" mass="82732" checksum="EC118597D13E5E95" modified="2018-07-18" version="1">MTGAFQRLQESLNEAKIAATHKVNEITTMNEKIVEMWPNKDSVERSGNRLTTDSGTKVYDADHWLKVVDPSTGHHGPSLLEDQIAREKIHRFDHERIPERVVHARGAGAHGYFKLYTPIPEFSSAPVLNDTARSTPVFARFSTVAGSRGSADTVRDVRGFAVKFYTEEGNWDIVGNNIPVFFIQDAIKFPDFVHAAKPEPHNEVPQAQTAHNNFWDFQYLHSEATHMSVWAMSDRAIPRSFRMMQGFGVNTFSLINAQGERTFVKFVWTPELGVHSLVWDEALKLAGQDPDFHRKDLYEAIENGYYPKWRFGIQTVAEKDQDKFEFDILDATKLWPEDLVPVNYIGEMVLNRNVDEFFAETEQVAFCTSHVVPGIGFSDDPLLQGRNFSYFDTQITRLGVNWEQIPINRPVCPVMNFNRDGALNHRIHKGKVNYWPNRFEAVPPASHKQETDSYQEYPARVVGLKLRVNGAKFREHFAQAQLFYNSLAEYEKKHVQAALAFELSHCDEPIVYKRDIDLALAQNVANMVGGDIPKEGRQNHGRKAPGLSQTDLPAIRPSIETRRVAMIIADGFDIGVLTAVRAALKAEGATTWVIGPRRGMIFPTGVDPESGTGGLMADHHLEGQRSTMFDAIFNGRAVHWVREAFGHLKPIGALGDAVSFLQQAVVLPGVDLAADPNSDEVVISYGVVTGWKSSVGILRSLDIEPSTSVFSSAFAHEISKHRCWERELDGLHTKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A668</accession>
    <name>A0A2T7A668_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_190967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000016">
        <property type="protein sequence ID" value="PUU83232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A668"/>
    <dbReference type="STRING" id="42251.A0A2T7A668"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1093" mass="117917" checksum="96B44F8858CA14AA" modified="2018-07-18" version="1">MDTTDISNSGGLVGAALHGGVADNMVQGQPSSSSQAEFVPYQHQLVFGPGTNEYSAIPESFPHTEYNPYPSSEAWNAPPQSTHQQHAQHYTSLDPMSHFTPPPHAFPQPFTPHNFPTNQHPFAATGAATTASPQIATGAPSTPPTVVDGVWREYSPAAVTTVANGTRGATNTKPTSITATRTKQPHKSPGIQQSFSPNVVRNTATSTSIATTPTPNSITPTTNVTASTLKTNDGIRIRGCPNVTVRLPHDPSLQLPQDFLKMISSVALGNDPPASVGPPKKNQKVASIASTPSTAGTTKVQPVKPAAPPKPKLPEDPAEKIRYQIEEALECDGGDDIEDIRKASKQIWDVFIGIRPEQSKLVEVAVRTILKVGDNQILRALGESILFSIRLRKWMTTEWNRDRNSPTVFMILKLLYKFCVSEGDLEQSSWIKALKSIGSKSEDQKTRDICVAITKSARERSAKKEREEKAREKQQKPASLATSSALPDRTTDKEKPLGNAAKSEASSNVNAGIKRKSEDDAKIGQFTIKKIALGEGKIPAVPSSLNSKTSLSTGNSKNATTPAAEKKLTTSTASSTSANGSNASAKPKATTSGFFKSLQGNRPAIVKAPIKPVEKKSTPNPESTTSTFTSIFDQLVRQQKEGTTGLRPDSDTRKRETDEDQNGSNKKVRKKKTVRWKTGEDLAKVKVIEWVEPEGEYYGGSSGHENHEYGNARNFDVEEGREALAALKNRNFLEDEEDLLDWYQPLRIDFSDLNHVSTPADNAISRGGNKEITSEEAEIQSKRELQTLSALYTSPAAIPYSPREPDSNNDNSQELDQQPTIIPLPDRLKPPASLQTAFGPVQLNPQPAAVADISSILSAINSFQQPAQSQTQAAADSILAQIQAITQNQQQPTAPPSVPFAQPVTQQIPQATPAPAQPDLGSILMALGPNSGQQQQASTSLLQNLVQQSSVAQGSTSAALTNILAQISSNPTAFSFGQAVPNVYDTSNPQVWPTYESQFHQPYGSTPNHSNQSSWATGSGTDEFGRILREGDREKEGRGGKDVRGALREATGWDERKSEVERHNGSGNNGNNGNEPTRGGWSGGKHKKKRKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A720</accession>
    <name>A0A2T7A720_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1105139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000011">
        <property type="protein sequence ID" value="PUU83490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A720"/>
    <dbReference type="STRING" id="42251.A0A2T7A720"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF105">
        <property type="entry name" value="ATPASE EXPRESSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU83490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63757" checksum="6DF21F30EB83D732" modified="2018-07-18" version="1">MFNCCACWGRNLTALISTHVPRRTAYSSAARVKERRFTGRNVRLYRDPHKLAGAVKKQLIQGDDNKALQLAREGGRWLNSVVSWNHIIGHNIERGRFRVAFKAFNDMKKTSISPDSYTFTIMLNALAEYPTRPTAHERALQLYHSMSRPNSPVEPQIVHTNAVLKVCARCGDVDTMWDIVLKLPLSGLGAPNAITYTTLLNGIQGAHEVEEGRRVWAGILSRWNSGKLWVDEELACAMGRLLLLGTKPEHWQEVFKVVEQVFGIKDPTSEEQEVNPGDQLYVEGTTKPISEIKELLQTPEDGDPNARAPYVPLPLRGQTTRGNPSSGSNSSITRPMPGNAVLGLVIKACTQLSDNELARYYWKTLTAPPYSVRPDMENFHDLLRLLRKSRSGPDALDVLHAMLSRRDTTPTAKSFFIAMSCCKREGRGPGFPAAEEMLILMDKHRVRIDVKVVTMFLQCAVKTGVPTYWKSALKTVEDIFDLRGELDKLVSLRAHSDLLETHVELAKWMQGIIDRLLETSDVPWGHGERTVFEKKKGMLVRLIERFGWVAGGAEGGGKNWKAKVIRGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A7S9</accession>
    <name>A0A2T7A7S9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_752509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000007">
        <property type="protein sequence ID" value="PUU83779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A7S9"/>
    <dbReference type="STRING" id="42251.A0A2T7A7S9"/>
    <dbReference type="OrthoDB" id="5403684at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015769351" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU83779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="18600" checksum="F95E01BA5D2D335F" modified="2018-07-18" version="1">MQPQTLLLILASVIPAMAVLDCGGGRAPPKTTVPGCPGYTGAMPTDSTATSGSTAVSVPTSTPTATGSSMTLSVSMGTSVSSSSTGTGSGPSSTKSMTASPTTSAKTGSHTGAANATSTSTNIRGTGTSGNGTATVTSLSGNNSTSGGSGSNSTSGSGSGSGSGSSGSSSSPTGQSNGAGKVVGGVSAMVLGLVGVVAFGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A833</accession>
    <name>A0A2T7A833_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1060650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000006">
        <property type="protein sequence ID" value="PUU83889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A833"/>
    <dbReference type="OrthoDB" id="5422012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU83889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="456" mass="50461" checksum="993F032DA62523F6" modified="2018-07-18" version="1">MWDTIRAAPRKYFFSSSSSTKPSSWKSDSQSTLAPVYPEILSPQKPASTALAIPKQKPIFTRSELLQRIKEGISEFDLPPDPAGKNKENHPLFGAQHKPRIPTLLYLSEDNRLDDAATGNQVLSQLKIALSDSYSEYISNGRGEHEVGYPDEVNVTQKQNKNPDSVQSLRLERPPRRDTPLPTVLEPKTNIPMQSPPTLSPITPRVSSPIHRLRREHRREDSVSPPSGLSPRALYLKEEAQTRPISKSKSLSIISSAKTASPRHRSDQVLNYRSPTSSLQILAHPQAPICPPGRAQTLQGNLDQAPHPGHKLASVPTTEGEELPMTMAQRLALGKERVIAMCGFPDPPLMSKSPPHLNTPSPSTNLPLPAPLTPPRPARILQPSDTPPPPTFKVPRKPLPPRQISPLEDILSLTEEDFKSQEQIKMMKNKPLPPLPRSESTLTISSMRSSISGRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8H2</accession>
    <name>A0A2T7A8H2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1071336</name>
        <name evidence="4" type="ORF">B9Z19DRAFT_1071338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU84019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="NESQ01000005">
        <property type="protein sequence ID" value="PUU84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8H2"/>
    <dbReference type="STRING" id="42251.A0A2T7A8H2"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033325544" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU84019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="185" mass="19850" checksum="0F1C91C63F2CAE53" modified="2018-07-18" version="1">MKSAIFSSAIAIFATLATALPTESANNLVARDHVKQVINSSAVVNIREDTPDTALGISGRGTVSRTDSKHNFQALVKFDIPDGLTGSKCQLAFAYPSLFDGTSQIQVFSIGDANIENATFNKRPFRDQFKGTFRVGWGEATVVDGSGLTFDCPVKGAKAYEVVSVGDNNDVIWYAPWGGLRVNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8I9</accession>
    <name>A0A2T7A8I9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1070826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000004">
        <property type="protein sequence ID" value="PUU84022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8I9"/>
    <dbReference type="STRING" id="42251.A0A2T7A8I9"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="221"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU84022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="326" mass="35820" checksum="B8B98197DB1B7A6E" modified="2018-07-18" version="1">MSAKNGNGGGNGKKKPTAAVHLIAGGGAGLCEALACHPLDTIKVRMQLSRRNRAPGVKRKGFFLVGKEIVKRETPLGLYKGLGAVVTGIVPKMAIRFSSFEFYKSLAKVHPETGRISAKAVFISGLVAGATEAVAVVTPMEVIKIRLQAQHHSMADPLDIPKYRNAAHAAYTVVREEGFRTLYRGVTLTALRQSTNQAVNFTAYTYMKQYALNLQPNISELPSYQHLLLGLVSGAMGPLSNAPIDTIKTRLQRSEARPGESALKRITIIAKDMFKHEGFRAFYQGITPRIMRVAPGQAVTFMMYEFIRGHIERFQVSGDNDNQYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8U5</accession>
    <name>A0A2T7A8U5_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1014248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8U5"/>
    <dbReference type="STRING" id="42251.A0A2T7A8U5"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="116"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU84135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="186" mass="20483" checksum="E674AD1CE5EB4E93" modified="2018-07-18" version="1">MASYEDEHNVKPPSARPPRPRIDFSEFFSALPTATTSSSTTTDPPLNGSAASNLFTTLAAAYQPNLDSNPTATLALIIEQLLSSATSHEPVDGVPDGFLDALDRVPKSKLKAEDECPICGERFLDDQFPLVVRLGCRGRHVFDLECIAPWLKIRSTCPMDREGLVKKREVVVVGEEEEEEFDENYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A8X1</accession>
    <name>A0A2T7A8X1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1070700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000003">
        <property type="protein sequence ID" value="PUU84152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A8X1"/>
    <dbReference type="STRING" id="42251.A0A2T7A8X1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU84152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="556" mass="60571" checksum="54DAE78CE8762E5C" modified="2018-07-18" version="1">MSTTNILAGCAASTILLSRYTHYTAITTFVLLTSLALTCKVLYHLILWPKLLSPTRHLPGPSNHSLLMGNFSIIREMQSGAPEAIWMRTIPNSGLLRYLGIFNIEQIFPTTPEVLKEVLHTKSYSFIKPPLVARNIGSILGKKGLLFAEGEEHKVQRKLLLPAFSHAHIKGLVPGFWSKGVEMTEKVVEVVRSSRDGAGDGGEEGVVVQMGRWFSLVTLDIIGSCGFGYEFRALESASISGSSNIEDNSGSELAGAYNTISNMGGPSRFVAMLSMIFPFRLVRSLPLKRTRDFERAASTIRRVTAQIIAAKKSTLATSPEDSESGDILSIMLKSNAYTGPDGECSMRDQMMTFLAAGHETTATSMIWAIHVLSLPENRHIQSRLRSEIHAAFPSGLPTTVIYDQISSLKYLSQITSEVLRLYPPVGVTPRVAAEDTSLNGAFIPKGTTIILSPFAINRSVALWGADAEEFRPERWASREDGAAAVESNYGFLTFLAGPRGCIGNVFAKVELKCLLAVTIGRFEFSQDGKREVVIKAGITSKPQGGIPVSVKEVVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A947</accession>
    <name>A0A2T7A947_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_277760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A947"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="110" mass="12483" checksum="6DE6C5C03A107DA1" modified="2018-07-18" version="1">MVDGCSWQCVWMAVPVVTGGWGLARLTNMEPKCKGERSTKERQDMKDRYPAAIRYHATQVPLLVLYARGFSHRPHIHCNEWEEEKSKIKTSHPLTAGNAASHHTVPCRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A967</accession>
    <name>A0A2T7A967_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_277715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000002">
        <property type="protein sequence ID" value="PUU84265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A967"/>
    <dbReference type="STRING" id="42251.A0A2T7A967"/>
    <dbReference type="OrthoDB" id="1872003at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF/GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38418:SF2">
        <property type="entry name" value="SUGAR ISOMERASE, KPSF_GUTQ (AFU_ORTHOLOGUE AFUA_6G08860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="94"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="439" mass="46436" checksum="1075DE0FFB76E5E5" modified="2018-07-18" version="1">MDSNRSNSDFFCSFRDGRNNSLLAQHLSSLPNTEAISSLPITPPATDTDPEDEEVLSTAVRVLSTEAMALSCLSRLYATDPVARNGFVKAVEAISTAVIKGGKVVIIGVGKSGKIGEKMVATMNSLGLLSVFMHPIEALHGDLGMVKPKDVLLLITFSGNTPELISLLPHLPGYLPLIALTSHTSYHTSPLTRERTKAILLPAPIHEAEETSFGISAPTTSTTVALALGDALAVVSARHVYTSDGEKPRDVFKRNHPGGAIGLGAGKGVVRMSDLAVRLEDIPVVDGILEDGLLDSPPISSASSESDLEITEWAGTDASLSATHTVRVIDCLLAGVGSKTGWVRVSKDEVVPPGRLKSVRGNVQGSVYEFEPSLVVGKSEMIRVSGQAKVEDVKKWVMTSREERRGAFPMGAVLGVSVGGTGQGEEVVAVIEVDELMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A9M7</accession>
    <name>A0A2T7A9M7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1118019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000001">
        <property type="protein sequence ID" value="PUU84437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A9M7"/>
    <dbReference type="OrthoDB" id="5415889at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU84437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19866" checksum="DBA5AE9CB78395F6" modified="2018-07-18" version="1">MPEDPKPQPKAENITRYIHALADSLKGLANEADSAPDAPLLESMAYFWTKSIQENHKSLKRQKELLEQLQKENLRVRKEMAKLSHRDSLNHTKAMISIRSHNSNLGKWEPLKYPPGTPVKDTLLPSTGAELLQMKDIQCQFTAGHLELPSLPGSPSLEERRRQIADYMGVSYPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9H2</accession>
    <name>A0A2T6Z9H2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1139237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000765">
        <property type="protein sequence ID" value="PUU72137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9H2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="397" mass="44583" checksum="65BC33CD70260EB3" modified="2018-07-18" version="1">MSDSSNPDLEDADPTLLHPSISNLSRKLKSTYHNTICKQQAGSSRSKSHLTVDLLSETSEEGNISIGPEKISICQENISSEISVSPTRKQWPKIIGIEQIFQNMVMEDSGSQDSQSNSDQEETDNIEQLKGKKKVEYEYWEEDSRNSIDSSEDEIMEDIESWQEERSLAEIGLGNGQNKGKTCLRLSILSGNEECMRVVEEENNYLADYEIPIIEKDISSNILSLKGKYQASELEISDIQSQRESTIPTPIMLSTISHQHDSVIEDSISHIISIPLRKPLHLGSQSPKTDASYLKSENISIRKPFSEKEIIEISSDFEPTTPISECSDGQELTLHYLHQRYSNNFGCSSHLTPPDHSALPSQQWSLSEIIKLLDQNLPVDYPVPGKYGYSGNISEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9K2</accession>
    <name>A0A2T6Z9K2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1138969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000707">
        <property type="protein sequence ID" value="PUU72155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9K2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU72155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="525" mass="57476" checksum="07FD1433E7901ED7" modified="2018-07-18" version="1">MDEEYASAIIAATLNFPHLPLRRRGWPGEHQPIITPSSFLQTEHDSCDDDFIAVSKSNRNDSGLIRPLVPSWKHFLTSIGLPTLLIPTDSQRPQPNYISGSLLVHGLNENVNPKENGVGGIMAAGGRSKLAHDPSDDGRHLEPMVVKKYRRRVLEHEGDSTRHGAHFLRSTQSLESGFSVRGGHDSTLISKIQDESTDSKYLIPIPATDSSKITSRHRAHESPEKKTASPLPPLHSDNGTLNTTQHLDYQQYVNLDKYCHDSIDSSRHGPDECSTRAGRISGSHTDMLGMSVFFGGNQALFFGRKDLEFTSDETEILGPEFPRNPTFFLKALKPLRIPRVVAHGTAEHELGLIPPTPEKPPSTPFRQRTAPINSSDDGFNSISNGSAFAGTTGSYRDRAQSPGDQILENAPASAPKSDLPRAIQPAVKGDVNGAIAQATYNQYSLGLPAQIENPPEPYGSEPANPSANTVPRSTHQVREEGEDETRDSFDDDGNNGPRCPGFLEALSLTRYLSKYCAWTKLTAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6Z9W2</accession>
    <name>A0A2T6Z9W2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1138198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000593">
        <property type="protein sequence ID" value="PUU72291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6Z9W2"/>
    <dbReference type="STRING" id="42251.A0A2T6Z9W2"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="69"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="291"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU72291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="489" mass="52454" checksum="7A60AFACA98281AD" modified="2018-07-18" version="1">MVFARLAPTARSKALSLLHTVQFTHPPTCPCHAPTHPFVASAPSLLNAARSLATPIGSQKEYAFEMAASSIRFGPGTTREVGMDFANMKAKKVIVITDKTIERLAPMWTAVSALESAGVKYEVFSDVMIEPKDHSVKKAIQFGKQAKGDSYLAVGGGSVMDTAKMVNLYNNFPEADFLDFVNAPLGKGLPITKALSPLICIPTTAGTGSETTGTAIFDLANKKVKTGIAHRALKPTLGICDPLNTRSMPPAVRASSGLDVLCHALESYTAIPYSERIPCPTNPILRPAYQGANPISDVFSFKALQMTVKYLPRAVHDPEDQEAQSQMLLAATLAGIGFGNAGVHLCHGMSYPISGGNKGYKHNGYQVDHPIIPHGVSVAVTAPAVFKFTAASNPERHLAAAEVFGVDISNARAENAGELLSDALKEFLRELGDQPKGIKELGYTSSDIQGLVEGTLPQRRVLMLAPKLDEDLERQKGELIKLFEDSLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZB35</accession>
    <name>A0A2T6ZB35_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_1008555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000479">
        <property type="protein sequence ID" value="PUU72708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZB35"/>
    <dbReference type="STRING" id="42251.A0A2T6ZB35"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU72708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="233" mass="25479" checksum="A9BA1E6BAF58FE1E" modified="2018-07-18" version="1" fragment="single">IVKLLLGRKDINPDFSDNHGRTPLSWAARLCHHEVVKLLLERKDVTPDMSGPFGITPLVTAAKHGSHRVVRLLLQRKDADPNTADDTGLTPLRWAAGRGDHSVVKLLLEREDHDRAHHYGQTPLTSAASAGSDRAAKPLLGCQKVNPNITDKTSKTALSWAARRGHDGLVKILLGRGDVNPDIPNYDGQTAFWWATSSRNKLAVNLLEARQPANGSKFTEVAPLGHGLNMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBK6</accession>
    <name>A0A2T6ZBK6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1007797</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000458">
        <property type="protein sequence ID" value="PUU72826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBK6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBK6"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05677">
        <property type="entry name" value="M20_dipept_like_DUG2_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="680"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU72826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="869" mass="95477" checksum="6C69033B1D1C0395" modified="2018-07-18" version="1">MSGLQAFSPNNGSRAGTPLPRFLDSYGFPINPPARKGKEGGGAIEEEIPTLLHRVKHNGSILSLCVSDTLIYAGSQSGEILVWSIETFQLVKSIQAHQGSVLCLYLSDDGSVLFSSAGDAIINVWNAKTFENLYSIYSTFDVGDVFCVVYSSALQTAYFGAQNTSIQWYDLKVKDSRPRPTLTSHPSYRNHRFFDSKGPGGRTTPRPASKIVPPSSRLLEVAPENIVQYAHYGYVYCMLLITLPSGSEVGGVGGEMLLSGGGDGVVKLWALDPVTSAIKDVKTLGAGDSGVLSMAINDTMLYCGLTDGEICIWDLDTMQLIRSLKTHCEDVLTMSVMGNCIFSGSASGYSRKWNQRFEHMSRWQSHSGLILASAATKRHGRLIYITGGNDDCVAIWDASALEQLESQILKSQNDQLLSSLSKLVSFRTVSSDPSYAEDCRRGATYLKQLFKRYGATATLLPSEEGRNPIVHARFGGCGTKSRSKGKTILFYGHYDVISASESAKAGWQTRPFELTGMNGYLYGRGVSDNKGPCLAALFAAGELVQEQELDADITFLIEGEEETGSRGFVDAVRRNKELIGDVDWILLANSYWLNDDVPCLTYGLRGVIHATVVVESDKPDLHSGVEGSRLNREPTIDLVNLLAKLTSPDGKVLIPGFSEPVRPITPAEEEMYTAITNAIVNKPDWSHLTAAQIKDHLMSKWRFPSLTIHKVSVSGPSNATIIPRAASASISLRIVPDQELSVIKDRLVSYLRSEYSSFNSHNKLNITIDHEAEPWLGDPENDAFRTLEEAVMDVWSEGNEERVRPLYIREGGSIPTARFLEKEFGAPAAHLPCGQASDQAHLDDERLRLVNLYKSKAIFKRVFRELPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBM3</accession>
    <name>A0A2T6ZBM3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1069422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000447">
        <property type="protein sequence ID" value="PUU72891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBM3"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="118" mass="13464" checksum="7F3E847E6EDCE35B" modified="2018-07-18" version="1">MAERIVYQAKLEKKIPPTGGIEEGLSELAERREFTDILELEAEASKLHNWDVLAAFDTLYHESKYSTNGDDGANIIVKETEFRDTERAALVCLLKLQSSWPCPLAWKEELHEFPKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBN8</accession>
    <name>A0A2T6ZBN8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_608411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000446">
        <property type="protein sequence ID" value="PUU72893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBN8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU72893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="57" mass="6370" checksum="C7E030B71DC1EACB" modified="2018-07-18" version="1">MIYLLTTPELHPTAWHPHLSNPTSGCHFEPAPPPYTLPPFGIFLAKEHFTVGCSQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZBX4</accession>
    <name>A0A2T6ZBX4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1096165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="NESQ01000437">
        <property type="protein sequence ID" value="PUU72969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZBX4"/>
    <dbReference type="STRING" id="42251.A0A2T6ZBX4"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU72969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="460" mass="50788" checksum="77D3FB21244766CA" modified="2018-07-18" version="1">MTTGEVQKTFDNGSSAGRIGGGNAWSPSSWQSKPMKQSVGYGDEEAVAKALKKLESLPPLVTATEVSKLRASLKEVALGKAFMLQGGDCAELFEYCTEEKISAKVKLLLQMSMDPLIIYLFSCSRSCVDCFRPRSSMTEIIDGKKIPSFRGDIINGFDISQRTPDPARLVSAYYHSATTLNFLRGQLSSGFADLHHPFEWTLSHVQNSETKEKYQAIVNSITDAIRFMHTIGADTSSSLGTVDLYTSHEGLLLEYEQGLTRLLRDPMDGNKAKWYATSAHFIWIGDRTRQLDCAHIEYFRGIENPIGIKVGPTMVAEDLAELLHIVNPNKEVGKVTLITRYGADKVNELLPGHIDAVAKSGHTVVCNTRSSPTGVKTRQFDNIMTELSSTHHIHQRSGTHLGGVHLELTADAVTECVGGSENLTDDDLLLNYTTYCDPRLNNKQALEAAFMIAAWYREKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZD30</accession>
    <name>A0A2T6ZD30_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B9Z19DRAFT_550638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000388">
        <property type="protein sequence ID" value="PUU73314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZD30"/>
    <dbReference type="STRING" id="42251.A0A2T6ZD30"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PUU73314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="139" mass="15184" checksum="450DAF8F3C986B10" modified="2018-07-18" version="1">MSLSSLFSDIYTSLTISPAHADAPPAEEHEEPSSDSKVEEEKKSAEPEPKEAEPVEEESEAEEAEEEEPEDTLPAITEECSESKECKPAKHHYGECVARVTAAEEGGANGPKEDCVEEFFHLVHCSAQCAAPQIWAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDB0</accession>
    <name>A0A2T6ZDB0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1103921</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000374">
        <property type="protein sequence ID" value="PUU73463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDB0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDB0"/>
    <dbReference type="OrthoDB" id="199930at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="10">
        <location>
            <begin position="101"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU73463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="210" mass="22384" checksum="399846415F32F609" modified="2018-07-18" version="1">MGTLITTLYPPPSTASQMRNPIDSATHVSIVAATSTIARVVAGILSDYLAPPVPTSDACPAPPPRKFPRCSRMCLLFSFAFLMLLGNLYVSLGYVQEHGENFWIVSSSIGAGYGAVFCLAPTVVSVVWGTENFGTNWGIVTMTPAVGATVFGSIFAWGYDHYANSHGICWGKECYSGSFMIMAVSVACALVGWTIAWRAPGGWKTRGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZDL0</accession>
    <name>A0A2T6ZDL0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B9Z19DRAFT_1003973</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="NESQ01000364">
        <property type="protein sequence ID" value="PUU73588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZDL0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZDL0"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="338"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PUU73588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="465" mass="52318" checksum="FF0F3A1B57536789" modified="2018-07-18" version="1">MAPATTASAGPAGAAAKLRKTRVVGPHISETPITLGNLWQHIDKLNITLIVLVPILGVWAAFYTPLRTQTLCWAVLYYFWTGFGITAGYHRLWAHTSYSARLPLKIFLAAVGGGAVEGSIRWWSRDHRAHHRYTDTDKDPYSVRKGLLYSHLGWMVLKQNPKRIGRTDISDLNEDPVVVWQHKNYLVVVIFMGLVFPSLVAGLGWGDWLGGFVYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWIIWVWKQLGLAYDLKQFRQNEIEKGRLQQQQKKLDRKRATLDWGVPLEQLPVMEFEEYQEQARNGRALVLVAGVVHDISSFINDHPGGKAMINSGIGKDATAIFNGGVYNHSNAAHNLLSNFRVAVIRGGCEVEIWKQASKENKDVDAALDSNNQRIVRAGNQVTRIAEPIAAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEH0</accession>
    <name>A0A2T6ZEH0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_1003119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="NESQ01000346">
        <property type="protein sequence ID" value="PUU73794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEH0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZEH0"/>
    <dbReference type="OrthoDB" id="5957391at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12110">
        <property type="entry name" value="PHP_HisPPase_Hisj_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000059">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU73794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="310" mass="35968" checksum="BFB85A4D8B63C14D" modified="2018-07-18" version="1">MPFSHHSHSGQFCLHAQDTLEQMIEAAIAKGMIVFSLTEHMPRDCVEDLYPEETAAHQTPFDLFRNFKDYYDAALRLRARYQHRIHLLVGFEVDYIRPSSIPLIRNLQSIYKFDFFVGSVHHVNTIPIDFDRQMYLRALESVGGTEDKLFEAYFDAQYEMLTRLRPAVVGHWDLIRLFSENPARPLVEYGPGVWNRVERNVNFVLSYRGLTELNSASFRKGWDEPYPRRDLAELVMAGGGRFTISDDSHCVSEVGLNYNRLLGYIRDIGLQEVYYLEKLPMGEMAINVLDACAVRSLTVDQLAQERFWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZEL2</accession>
    <name>A0A2T6ZEL2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1196579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000333">
        <property type="protein sequence ID" value="PUU73930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZEL2"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU73930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="229" mass="25796" checksum="EDDE174A48D0C91A" modified="2018-07-18" version="1">MEQNNNNHTILHQDRRSNTRYSTKPNRHEDTPRNAIPAFGWTSFSLRCLTAIDLAVGVLSHLKMSGDILNVQVVAKYTILKILEHITRRAGEAVSRVTGRISLADGREWKDAMVCPAGYRNNRGTHGSSGEKWVQLRFPGYWVQIAIYTISAYRIGGVITRIVRSTISRVYVSRYSRSSRPHSWPIFKALENSLANIRSLAVGPVKEVTASKIDSITDKINNSMTTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZFX9</accession>
    <name>A0A2T6ZFX9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1196288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000304">
        <property type="protein sequence ID" value="PUU74379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZFX9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZFX9"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="567"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="512"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU74379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="68811" checksum="EA78381C090B55CC" modified="2018-07-18" version="1">MTTTIHRQIGKLGKRSADEATVAMLIKEVNDAEILLGKLIEHTKAWRDSWSDILVNQTILTDSFHDMYKAIPLPQDYNIQVVETPVPVLRKVAKLHAAQNDLKTDMMEEIERVDKMLVERLSGAKAALKPIKKAIDKRENKKLDFERFTKTVDNQRGKKNKSDRDYSVLSKAEIDLERAQNAYENADNHLKDWVPKIMSKITEFLPCVVESIVQTQYTLLSNAYSAVYEYGNEFNFTDPDGEVVIAEWEDLFTPVQQQVESEISFIARGKAITMPMTQLAQEKSYMPSIPRIGRGKKPPPPPPPANPPAAATPDETSRLGKMMPSRFSREKEEPAPSPSTSGSSKPSIGSTRSFSSNREREESPSRLSSRPTIGGAKRSSGGRDGGISPPPPVSRARTTIGGIKSRTSNSGLSVSRDESPPPPLPGPRPGQPGSRQSSTGEVQQHDFRSVIKSRSATPLAGIAQNSLAPSQRSDLVRIRSAGSSDGRQPEERFLGAVSPSAIRAAERSLSMGASDYQNSRPAVSRSPTAASVSSYKTTVSDTGSLSSIAGKKKPPPPPPPKKKALGKGETWVRALFPFEGQDNGDLAFKEGDKIKVLKKTESTDDWWEGEVHGRKGQFPANYTEIITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZGM6</accession>
    <name>A0A2T6ZGM6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinetochore complex Sim4 subunit Fta1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1092247</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000283">
        <property type="protein sequence ID" value="PUU74648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZGM6"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU74648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="299" mass="33041" checksum="6E1820D3BF95DE9D" modified="2018-07-18" version="1">MSRNPPQSSKPLVHPLYNVTYTIHRLSPLYKFPPRSDFKSHARSLQQILRGDVLRGVRIALDNEDEALGRAGRLKTVTWEVLPSWQTSSEDDEEEAAEEEAGSGVKIEMQYEKTTYTSLLLSSPLGATGLEDGDQEFTELPLLLTRLPKSLRDTLLSYLSTRFDILPLPLALPSSLLQRSMEYYFSHTYSPPKDAQISFATPTTTLKTIAVTIPRDDIAKFCARGKQLPGGGFYAALKHYLRGTMALDAEYLTIAKVACGGFVLGGGAGGKVKIFPPRDVEEHEAVRNLIQELVKAADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZHB8</accession>
    <name>A0A2T6ZHB8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_997561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000266">
        <property type="protein sequence ID" value="PUU74869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZHB8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZHB8"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF1">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="2">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="3">
        <location>
            <begin position="168"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU74869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="306" mass="34087" checksum="8D3942CFCDDFF4C2" modified="2018-07-18" version="1">MSLWPNKPIFEPDFKYSSLDEAIAIDTVNIKAGEYLATLPRDWCIGLVPHGGYLTSLLLHAGTKHMTSHPELSKLNQPHPIHSAVTFLSRCAPGQARLVAAALKTGRQYTFLRVSLYQGVLCLEANIAFTHMAEHQNGPTLRTIPPPPPPRSDGPWDTTAGDPLHDVRPVAKKLLYKATSGSHFGSDRENSPSVREDWVKMADGSKFSITSLGYLSDMFLPLPENYAEMGRTHWYPTLALSIEVKRGPERGGWDVLFRRIESRVIENGRMDITVDMYDEEGRIVAISHHVAIIVDAARNRTKVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZI65</accession>
    <name>A0A2T6ZI65_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1091031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000248">
        <property type="protein sequence ID" value="PUU75146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZI65"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="148" mass="16202" checksum="A94D912BC1ED1B7D" modified="2018-07-18" version="1">MLLERGNLNSDAADRSGQTSILQAARDGARCVVGMQFGDDPNINVPDFNGEPTLPSADHNERPKVLDLDDSISKSADNDLSSTEPSRQSPTWPLKPWYSPKNTHTHLNTQSAPSFAVDRSFIIASLVCLLAFLLEVLPLLLDILSPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIC0</accession>
    <name>A0A2T6ZIC0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1090883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000243">
        <property type="protein sequence ID" value="PUU75223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIC0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="64" mass="7367" checksum="4A7C88C878A382E5" modified="2018-07-18" version="1">MVEVWGIILRDERPIKEVMPESLYRGTYTDYENTIQRTIDTNASAYGLEQQCCCLSLKGVVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZIG8</accession>
    <name>A0A2T6ZIG8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ACT domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_995698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000244">
        <property type="protein sequence ID" value="PUU75204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZIG8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZIG8"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="112"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="380" mass="41154" checksum="0E05322F8269D3C9" modified="2018-07-18" version="1">MTYMSSSVQFLECRLSLIHIPLHLYPHFVQAILSLILPSISPSSEDRKAWDEDFVPDYYSAGRPSSSIENFVNVSVTPVECSVVCSTEQVENLFVPIIQTLSSSHREEVKISEDEFVAIQVDGEGLDAGQRVLDLTSPLALAGVPIFFLTTYFSDYILVPLKNRSNVTKALQRRGFVFEKHLEAFVTSPSHHRNSSSTSSFSAAPPSPPPTTTVSELQIKTFETLRKQSVVPQVNKNTRLVLCAGRRSSNKGRGSDDRGLYLGLVKCLISKPQFLSVTLTDTEPASLLLEREMLSMFGSDDALLGSKEDVLIPILLDLRGLPVDSTGIVCGVAGKLVGGTAGGILDGTEAIEMSYLSTARAGTVIVAEDDLARAVAALGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ41</accession>
    <name>A0A2T6ZJ41_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1102938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000229">
        <property type="protein sequence ID" value="PUU75492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ41"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJ41"/>
    <dbReference type="OrthoDB" id="3433692at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="268" mass="30242" checksum="2FA6321039BABBF6" modified="2018-07-18" version="1">MTSTDQDTFTYRYDGPPINRTAYRNLFIYDSDNHDTVLGGLWVAEGVTNTNLYSMADILCIFTNAFDLQDDKQCLVERNEQPLRPGNYYIVTNGSISVTNEVPLLRTLSTPSGTRVESFFHSITVPPASESDGSINSVQNGILLTLDTHILFDCYDFSINPDDGYKIVCFSPLASHYGIAGRQLDQRLLDDPLRPVDQLFRWHFRQAVLTNMKGAGEVFFEMDFPPDSDMMGQIMSGPRAAERLEFELFTRLNRVEGQCSFINCLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJ50</accession>
    <name>A0A2T6ZJ50_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_889785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000227">
        <property type="protein sequence ID" value="PUU75503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJ50"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU75503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="51" mass="5713" checksum="DAD803A8BF489B79" modified="2018-07-18" version="1" fragment="single">IPPNGHFFGQIPQPMHNRSEIKAILDSGVTSIQSFPVLTTGHDFLHSCRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJG6</accession>
    <name>A0A2T6ZJG6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B9Z19DRAFT_1030611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="NESQ01000223">
        <property type="protein sequence ID" value="PUU75596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJG6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJG6"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PUU75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="468" mass="52448" checksum="0F265215B724FB5B" modified="2018-07-18" version="1">MAPVPTLQPFHVLDDARKDDKTLPAFMVSTTRGFLPRDEPITELPAEFAALDTLLHRCPIKTATGEPGLLAEGRLGEVVEQEFPNLVEHVGKFANDQAMLTALYRDYSFLASSYLLEPCHHNMLKSGSYGLGRSVLPENISMPLAEVARLTGFQPYMEYAGSYALYNYRLLDPTLGLTYDNIAPIRAFENGLDRTSSEAGFVLTHVDMVKESPELVAGAMNTLKGAEHYLAHGDKQLFKDGLKEVMNSLTKINSVLERMWSRSKPGEYGNFRTFIFGITGQSMFPNGVIYKGVSDTPLSFRGESGANDSMVPLSDNLLQISMPESPLTEILKDFRKYRPGNHMEFLSWVKSSAEQVGIKKLALEDAESATLYLHALDQVRDFRWRHWNFTREYIIKKTAHPTATGGSPIIRWLPNQLNAVINTQMEVFKVLEDLNCVTPKIAEVREKVTKQKGDLTKEVEKFCAERGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJR2</accession>
    <name>A0A2T6ZJR2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_993271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000216">
        <property type="protein sequence ID" value="PUU75725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJR2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJR2"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU75725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="325" mass="36420" checksum="9F3B4531A6316CDB" modified="2018-07-18" version="1">MSTEKKEIVVLGAGVIGLQTALTLLEFGYSVTIIANYWPGDDHIEYTSPKYHWRTHAGPDDPQGRRFDKETYEHWLELVKKDEDTGLVLIPEIYIWDHPTPEIANSGASIWWSTLVPDFVPLTHPHPLLPATAHFGISYKSFCLNPQKYLAYLLSRNADHGVKTHTHEVDSLTDVFEYVPEAVGVVNCTGLGAIDLVDPVEAEKLFPTRGQTILVRGEAEMARLRIGEGYIAYVIRRPGEGTILGGCKVDGDWNAEVDKELSKKIVERCKILAPELLVDGEFEVISEQVGRRPSRKGGPRIEVEWKEAEGRRRFICHHYGHSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZJV6</accession>
    <name>A0A2T6ZJV6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_993498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="NESQ01000218">
        <property type="protein sequence ID" value="PUU75694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZJV6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZJV6"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU75694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="362" mass="41592" checksum="D414CD8B68E4F828" modified="2018-07-18" version="1">MVPAKTSKQVTNDWLWTYQEEPHRTRRHQIIKAHPEVTKLCGPEPLTKYVVLAVVSLQIFCAYILRSTPVFSCRFFLMAYVIGATANQNLFLAIHEISHNLAFRSAFANRMIAVFANLPIGLPYSAAFRPYHLTHHKALGVDGLDTDLPTKLEAIFLDSVLGKAFFCTFQILFYALRPMMVYQIPFTRLHFFNVIAQLIFDAILVKTCSGNALTYLIMSSFLAGSLHPCAGHFIAEHYVFERPKPLPKDAISDGPAPVETYSYYGPLNFFTYNVGLHNEHHDFPGIPWTRLWKLREIAKEFYEPLPRHNSWSYVIWQFIWDSDVSLWSRVKREQQVKSGRKVTAGWTKEEIEGMNGAVQKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK04</accession>
    <name>A0A2T6ZK04_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_992945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000213">
        <property type="protein sequence ID" value="PUU75820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK04"/>
    <dbReference type="OrthoDB" id="5358110at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="98" mass="10918" checksum="9AFB36EA8D1E5C2F" modified="2018-07-18" version="1">MISRMATYTCHRCVFGRLLRSAFQLRFQSSVGPKFLADGLLRRAQQLSNEHSGLEKQLADSYDKKLATRAGRLASVSQSLKEYQDAIAACSQSLFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZK56</accession>
    <name>A0A2T6ZK56_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1089387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000210">
        <property type="protein sequence ID" value="PUU75871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZK56"/>
    <dbReference type="OrthoDB" id="2142759at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="126"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU75871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="314" mass="35703" checksum="742C81A1DE5312EB" modified="2018-07-18" version="1">MTSTDENRLLIRPVNRSAWRNTHIYASDDRDTALGGLWVAEGITNTYLYSMVEIFCIFTDTFGLQDDSGRLVGRDEQPLRPGNYYIITNGSITITDEAPLLRTISLHTGTRVESFIHSVRDRDRRCIITGRSAVMAGVSFWENFEAVHVFPLAYEENWNNDNFSQWITVPPDSESHGTINSVQNGMLLTLDMHAMFESYQISINPDDDHRVVCFTPYASSYGITSAHLDQRFLNNPLRPVDQLLRWHFRQAVLVNMKGTGEPCFEMDLPPGSDIIGQIMSGPKAKERMEFELFSRFNAQGFTRKAKLGSQVMCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKD1</accession>
    <name>A0A2T6ZKD1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1066997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000208">
        <property type="protein sequence ID" value="PUU75942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKD1"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU75942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="188" mass="21491" checksum="3B2DD10D058591E0" modified="2018-07-18" version="1">MPDDAMSVKPPTHHQLAFLSISRIAASMETSGHNNDKKTHIILPDATLNRNIKPALKTVSLSVIPPSKLKSRPPLPRTARVSKLPDDKWGKRRERRETYPISMEPLGSPPQKVLKGLTTTHCIKNEGRTLISHQPVDDDTDSSTPRRHGMQRASKQIVTGLRRWYLSYRCRHRFVFDPEIHSFERANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZKL6</accession>
    <name>A0A2T6ZKL6_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1066961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000206">
        <property type="protein sequence ID" value="PUU76037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZKL6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZKL6"/>
    <dbReference type="OrthoDB" id="5414285at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU76037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="207" mass="22117" checksum="CC88854F5DACDC6A" modified="2018-07-18" version="1">MSGGGVAVLVIFLLLLFAGIGWIVFTQLRARRLGLPAPTWRTYVPFLPNNSRTAPAPASYEPSRSGLVGKITGVFGSNNSGYSGSNVRSQRTREMDGEWDHRIEDEDEGAYGAGYGGQRGRDAGLGPGGGGVGGNGFEERGRSRSREPPRDLGTRTAPYPEELNPFAVDARLQGVRDRDEGFGGVGVKGGRASVDSERRSAFRESIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLG2</accession>
    <name>A0A2T6ZLG2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1194796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLG2"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU76328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="103" mass="12416" checksum="900242608A3D257B" modified="2018-07-18" version="1">MSGGFESSIPLQTQRQNYYTSITKKQNNFLRSNYKRYRKKARFKMRESQTIPRRFIPYARLKAFLDNLFPHNYSITIIEELYAIKVPRKLTDSEIDTLQEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLH6</accession>
    <name>A0A2T6ZLH6_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B9Z19DRAFT_990852</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="NESQ01000191">
        <property type="protein sequence ID" value="PUU76342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLH6"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLH6"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="253"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="552"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PUU76342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="647" mass="74503" checksum="E4F1F7CB5CDCE1A2" modified="2018-07-18" version="1">MDVPSSSPRRLPPRNPAHQSQSSSSPPKHINEVFPLAPPPPLHTRSNNESWNPQPSSEEFITPSSSPSKGNTALVEVFDRSLQLTPSSSPTKPQATPSKRMLQAIDEDGNGAGAGVGRMDDERLNRKNNKENAPPFSKATEVSQRGNAGPGLQRSHAQSRRAYDPFRDMTIDEIEKLSKPQVKRLKDVAHLYFYDYYYNLVTYVHTRRKRTEDWKAQHENLSTEELKPAWSRFAGRERVALRKRRTRLRKGDFQVLTQVGQGGYGQVFLAEHKETKEVCALKVMSKKLLFKLDEIRHVLTERDILTAAKSDWLVKLLYAFQDEDSIYLAMEYVPGGDFRTLLNNTGVLHFNHARFYIAEMFASVNALHDLGYIHRDLKPENFLIDSSGHIKLTDFGLSAGKLSPDRMESMKMRLDQVKDMDIPERSTMERRRAYKTLRETDVNYAKSVVGSPDYMAPEVLRGTEEYDFTVDYWSLGCMLYEALAGYPPFAGATVQETWHNLKHWKKVLHKPEYENPNYYLSKRTWDLIIHLVAARDQRFQDFKSVQSHGYFSEVNWGDLRAKEPPFVPELDSDRDAGYFDDFSNEADMAKYKEVHDKQNALESMEERKDSMSKIAFVGFTFKYNSFLQRLEMLYRANSHQQAQEAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZLZ7</accession>
    <name>A0A2T6ZLZ7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1088150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000186">
        <property type="protein sequence ID" value="PUU76509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZLZ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZLZ7"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU76509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="620" mass="65990" checksum="DA19F46019091885" modified="2018-07-18" version="1">MAPVGYEPTPTRDSLELDSLVSSSASASPRSSTSSRSGISSSRRMSLASDDEDVEPGRPRAHRSYSVSSAFDFNTHLVPLTSSAESRYQQLGATNAPGSNPVGTLEKQKTLTYLNGLSLLVGLQIGSGIFSSPSQVNNHTPSPGVSLIVWAVAGLLAWTGAASYAELGGAIPLNGGSGVYLRYCFGELIGFLYSWTAVIVLKPGSAAIIAIISGEYINRVVTGSFTADADAVLPSEWANKLIAFLCLSLVTALNILSTRLTTRLSDSLLFLKVGSLLAITVIGIIVAATGLNGDGKGASTEWKDKGWFNSRKGGVSGRESESMVGGLGEYAIALYAGLWAFDGWDNVNFVVGEMKNAQRDLPRVIHSAMPIVITSYLLANVAYYLVLPGEVIGRSNTVAVAFGTKVFGTAGGVVFALAVSLSCFGALNATTFTSSRLVYVAGKEGYLPAIFGTLGFRGGGNQPSRRSPGTNKKSILERVLSIFGRGASSGESSVHSWNKTPIYAMLLNSFLTTLYITVGEFGTLLTFYGVAGYTFYFLTVLGLIVLRVKEPSLERPYRTWITTPVIFCCVSLFLVSRGVFSSPLQTLVVVAFVVAGIPVYYWRVGGWKGWKLPWRKSING</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZM92</accession>
    <name>A0A2T6ZM92_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1028600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000183">
        <property type="protein sequence ID" value="PUU76566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZM92"/>
    <dbReference type="STRING" id="42251.A0A2T6ZM92"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="3">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU76566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34536" checksum="01BDAC7EAC8E99CD" modified="2018-07-18" version="1" fragment="single">MPNITLIGTGTIGLSWCAVHLRDPTNRITIYDPREDLVPYIKSLLPQYLSSSISSPATPSIETLLSNGTITLAKTLDSACTPETYILQEQTPENPLGKQVLWSNIVPLLPETCHLWTSTSGIPASTQAQNLSASAKARLLVVHPFNPPHILPLIEIVPSPDTSAGEVAFAMDYWKGREGHTPILVKKETKGFVANRLAFALFREACKLVADGVVGVKEVDEVLEESLGVRWAVKGPFASYHDGGGEGANGGLKGLLGKVGGTIDEVWKDGMGGKEGLKGGWEDAVVGQTEEVYGSVTKRGLWERDWVTRRVLEVRGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZN18</accession>
    <name>A0A2T6ZN18_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DnaJ-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_217011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000170">
        <property type="protein sequence ID" value="PUU76889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZN18"/>
    <dbReference type="STRING" id="42251.A0A2T6ZN18"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="11"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="148"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU76889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46641" checksum="A1F197D460F72D72" modified="2018-07-18" version="1">MNGSTEAESIDLYEVLGIESSATKVEIKKAYHKAALSSHPDKVPEHEREEAENRFKNVSQAYEILSDDEKRARYDRFGMTDFTAGGGMGGMGDVDLEEMLSHVFGMGGMGGMGFPGMGPMPRGPGGRKQKGKDVVQQYEVSLEELYKGKTVKLASTRNILCSLCKGSGGKDKAKAKKCANCSGRGWNQNLRQIGRGIVTQENVICVSCKGSGDVFREKDRCKKCKGNCVVEEKKVLEIYIPRGSKEGDKIVLQGEADEAPDHETGDIIFLLEEKEHDVFSRAGADLTAPLHVSLAEALTGFSRVVLKHLDGRGIQITHPKGKILKPGQVLKVEGEGMPLKKGDGKGDLFLVVDIEFPVDGWVPDADGIRKVLPEWTGEEVQAEQVDDVIFDPEGDIDDYGNSDEAGGGAWVDEDDDDDEDSNRQCAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNJ8</accession>
    <name>A0A2T6ZNJ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_199840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000165">
        <property type="protein sequence ID" value="PUU77057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNJ8"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="111" mass="13007" checksum="7F61879B280EC472" modified="2018-07-18" version="1">MKRREEKKREKGRQKSQEELFLFFHSWRLWLWLCIRSRFCSHVLSHIPVLANLSGGRQTLFLQHLLQLISPSTKGASGTVRSDKILFIVTNAYQRTELRPYCTVLNCTQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZNQ2</accession>
    <name>A0A2T6ZNQ2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1128726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000163">
        <property type="protein sequence ID" value="PUU77106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZNQ2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZNQ2"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU77106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="603" mass="66499" checksum="CA6A6CEB9FEE5EFC" modified="2018-07-18" version="1">MGVGIYELKPARQVPGTVTLYEDQGTEEALSRTSHLKHGTGKDSKLLLVPQPSNSPNDPLNWPWWKKDLTLFVLCLTAAVAAALGPAIAPINKMLVDEFKTTYKVTAKFAGWQFWPAGIAGLFGSAVGRVWGKRPVYIVSTLLLFIGAIWNALAQNTDSFLGARILQGFGLGAFETIVPSTVGDMYFVHQRGKRIAFYNLTFLGSTYFMPVLGGYISTRHGWRSQFQIISAFLGLVLIIVILLVPEHAYNRPAIFNTDLYSDGDLGELDDQLRKAMGAKTEGGMEVDEKSATSNGAEQEGIATPEREIGSGSCLKSGGITATVEMPIVSSGEVTVADSSEERKTWVQELRVYNGRFSDESFFKLIFAPFALFLYPATLWAFSFQGTFITWGIAVSVVLAQMFAGPPTNFGPEKLGYMYTAPFIGALSAYFFGASVSDWSAKWMARKNNNIYEPEFRILLVIPVAFFGLPGLYAYGHVADMHLHWIFPSILYGLLTFAVVVSCTATFSYILDAHRDIAVEMMVSMLLLKNFFAFGCTYFLVDWVDNDGPARVFDILGAIQTAVCVLSIPMYIFGKAQRDFMARHNLLKKWGLYPKSAETALPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPA0</accession>
    <name>A0A2T6ZPA0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="4">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1101884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="4"/>
    <dbReference type="EMBL" id="NESQ01000155">
        <property type="protein sequence ID" value="PUU77319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZPA0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZPA0"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="79"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU77319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="579" mass="64698" checksum="FE9BE5D05AA0AAE4" modified="2018-07-18" version="1">MLSSTNHKSILSLLAEYDDFLTDSLVDRVHYWTTIRKIKGPYHQSRRLNTKAILKIVTEDVVRDRNVKVALEKFLRLPRVVQYLRSGIHVEAEFSKHTRSPLPGLHRGEMVKYLTGVLVKMSDNEEQSFSQVQSDFSIIYSSRVGAMSLLLGPARFINHDCEPNCKFTTTGKEHVNLYIERDIRVGEEITVKYADDYFGEGNRECLCRTCEGLGRSGWASDVVVEDRPPIEEDGSAIRAVAGGFVLARRSKRKRNSAHSPTIQAIKKHKIFANDSLVPSPPNSIRGLSEGLRSTPPALDMSMHSRSSTPMLGMIGPETPPETDGAVTPMDFTDVSGASALLNASEARVGEINEPLQCAPSSLPLAELAEGCFLGESVHLEAVANPSRSEPQAQPLPQIIIDPTCDDYVSGVGLEEPSAFTSSSFDDTLKESESNARHALDDELSDFTEVDDSDFDDETQTIDVKRLMRKQRAKAEKGYRVKASEPHFRPPGPPMRRVPGDYLAQNRSSVSCICSNCRESFFHDEKFGVPTICKRCERHTKIYNFGWPKTMGKRNETADQYNDRRGIQRPVILNGHGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZPT3</accession>
    <name>A0A2T6ZPT3_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B9Z19DRAFT_1145924</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000151">
        <property type="protein sequence ID" value="PUU77491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T6ZPT3"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000628">
        <property type="entry name" value="Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 16" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="351"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="20">
        <location>
            <begin position="543"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="967"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="17">
        <location>
            <begin position="1130"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PUU77491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1411" mass="159634" checksum="0B27F92129CBBD81" modified="2018-07-18" version="1">MSIKSIASRGEKIIGDPREYQLELFEIAKTKNTIAVLDTGSGKTLIACLLIRHMIEKELESRAAGNHPRVSFFLVHSVTLVFQQAAVLRCNVDARIGEYCGNMGAGDWKKETWDDVLGKQQVIVMTADILYGCLVHAFIKMQDINLLCFDEAHHAKKKHSYARIIKDFYLAEPENTRPKIFGMTASPVGSRADAAHAAADLEKLLHSQIATTSDLALLQGSISRPEEAVTAYPRLKPKFRTDLCQKLHKTYGELDCFSKIFAFAELAASELGPWCADFLWKFALSETQARKLERRTERKLEAQPDIESIARIEKEILHLQEAADIVRKYKIPPPSADASHLSTKTLLLHAYLKEIYSVKTKAKCIIFVSRRYTATVLAELFKRLEIEHLRIGILVGSFARPGVADANFSFREQMVTLSKFRQGKLNCLIATSVAEEGLDIPDCSLIIRFDLYRTMIQYVQSRGRARSSVSKYIHMLERGNCSHLEILNEVRNSEKIMRDFCCSLPADRILDPAGPEEPSVTDNPEELYHIEPGTGAKLTMTSSMTILSRYSQRLPQEDNEPLQPLFTIRHVPEGFVSEVTLPTLSVVQHIEGAPMPTKMAAKRSASFVACLELRRKGQLDENLMPKSRSKRHPKMANAHLALDIYNSNVYPRRGKPDFWKVDTPLLELWFNILSLSNPAGMASEIQPICLITRNKLPPIPTFTVYSDKGVESELILLQLSKSLRASPDTLKKLCQFTHRLFLDLFNKTFELTLDTVPYWIAPIKDSNFNEDSLPENTLDWKLLEEVSFGADIFWDDNYPVENLIGRFLIDRRQRSRRFIVLGHHPTLKSTDPYPPSYECPPGIIDIQDYSYNATIPESEPVLIAERLLHRLSYLSAPDSKWVTTDNRAVISPSAFSISSIPSKVIHMAMIFPSFITRIDSYLHAWEICGRLGIEIDVGVALEAITKDSDNTHEHGSAQVSFQRGMGNNYERLEFLGDCFLKLATSLGLYISYHADDEFELHVKRMILVCNKYLFSKAIEMKIPEYIQSTGFSRRTWYPEMKLLIGKGTAQHNASKEAASHRLADKSISDVCEALIGAALIDRGLDGATQMVTAILGTPEHTQKVWADYYNSYTKPAYQLLESSPAQIKFAQDIEKLVKYKFKHPRLLVSAFTHPSLPFSWDRIPSYQRLEFLGDAVLDLVCVRYIFQKYPHADPQWLTEHKMAMVSNKFLGMVSVEMGFHRKLRRMGASLDHAIRDYEVDIQEAKANSNGAVDFWTSLKPPPKALSDVLEAFIGAVFVDSGFQYSIVEGLIDTFILPYFVDMTVFDNFAGQHPTTYISRRMTDLQCGSWGFESQQCTTGDMTYILTAIVVHSEIFSYGSGASVKAARIEASLAAMKKLEEPEGLKQLKDFCNCAEVREKRIKEKENNEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQ64</accession>
    <name>A0A2T6ZQ64_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1085909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000148">
        <property type="protein sequence ID" value="PUU77574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQ64"/>
    <dbReference type="OrthoDB" id="5308969at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU77574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="503" mass="57255" checksum="DA59781EC35835B6" modified="2018-07-18" version="1">MTHTFWGFQFGSSRLLDTSSYTFKNGISPRYATTVRIFPVLDALSSISVSREKSQVIAVGLQMNHETNEIRLLIADNHHVSQALLHHLNKVWRKLQSLSDRYAEHRVRTGRSENPQYQVVSPDIPIQVAALKVEIFRDVYLYSLQKQMRRVDKWFQRLGKFVRALLERRGPSNLDDFEQNLSDTVIVLLIALKLVCKLRDNPETPLTDTEWAVVCSHSMAANENVGGLLADRNESGCEILAEELKDDFHTGNPPEAFALRRALVKLTALPQHIETLFGFAHSPRLRPALQYSMSIVGVPGRCRNAELPSKQAGWAQFLKTIWGEEHRWHKNVAWELAGKKWFAAQKYMCMIHCECKLIHYLETSHASRWDNVARFPYLGVSKLSCGACRIWISSFNELGGRQYYTRGSHDKWYWPWGMPIMGPALDKVMDKMMAKEVLLAYISHERTSGRLRAESESTGVSLLGAQHRPSKGQLKQVKANTLALRRAFGGDLLLLARSEFPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQF0</accession>
    <name>A0A2T6ZQF0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-terminal phosphate cyclase/enolpyruvate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1085627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000143">
        <property type="protein sequence ID" value="PUU77720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQF0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQF0"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="15"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="196"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU77720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="402" mass="42428" checksum="F12082A9D0BE9EC0" modified="2018-07-18" version="1">MTTATITPTAPIQFTTHSSLRRRLVLSTLTGAPLRISQIRATSLKPGLTPYEFSLLRLLDSLTNGTFIEISLTGTTLLYKPGLITGNSGRPLVHTIPENCPRGATYFLEVLALLAPFSKSAFSVTLKGGVITSATTEDYSVDTFRTALLPVYASFEVTRGIEVRTLARSSGPLGAGEVHFLHGHQVRLPRTLHLQNPGRVKRIRGVSYSTGVSAGNNARMIEVARGVLNRFIADVYVFSDVSKAQVVPADYGKEGAVEKAAGNMKGRAGGKTKKTGVGFGISLVAETSLGTMYAADAFAGPAEAAEDVGKRAAVMLLEEIRIGGVVGRHGLMSVLVMMMMGVEGDVGRVVLGKEAVGEEFIAGVRDLKRVFGGEVAVRDGENGSLVVSVVGRGVGNVGRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQJ8</accession>
    <name>A0A2T6ZQJ8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_985784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000142">
        <property type="protein sequence ID" value="PUU77747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQJ8"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQJ8"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU77747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="200" mass="21823" checksum="388A3C43F26F7E6D" modified="2018-07-18" version="1">MAGNDVLHKTTSGATYPSTLSHLNVSPPDLLPTIPPVTRLAVGALVFRKSQLTNAPPTLLLVRRAVGELSFPGLWEVPGGGVEPYETILDAVVREVKEETGLVVGKITRCCDVENFQGKRSGRATRKWQFEVEIEGEGEEVVVVDPAEHDEFRWAREEEIQELVITTEEHRRVIMDSFRLRKAGIAAVGGKGVEASGVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZQT2</accession>
    <name>A0A2T6ZQT2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_897354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000138">
        <property type="protein sequence ID" value="PUU77842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZQT2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZQT2"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU77842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="180" mass="20028" checksum="AF8CC200CE3EA326" modified="2018-07-18" version="1" fragment="single">LAFPLLLSAARWIDPSLDADVYADEPWIYGPALASMSTISTSSSSSSDSKKKQSEGGGEEKEEKEEEEAGGLVEDNGLGLTAKARRKHFLTEAKRKEWVFEAGKEYKMEFSGPWLDFGEFRVVLPGFRVDILKYWDGQPLRFVLRNKESGEDYLVVEFELVDGEEGEGSDGRSTSSGEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZRS0</accession>
    <name>A0A2T6ZRS0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_984158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000128">
        <property type="protein sequence ID" value="PUU78163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZRS0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZRS0"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29314" checksum="11A1FE4740C84A82" modified="2018-07-18" version="1">MSNELSYPKTSANKVNRFNNRAHYDTTTIHNIINTTSVLHVSFLTPSNPKDPTSPQLPTILPMIGQMGSFTYPSSDESEALDCYLHGYVSSRLMNLSRNSTATQKGIPVCIAATKVDGLVLSLTPNSHSYNYRSAILHGTATLVEDVEEKIYAMRLITESVLRGRWLGTRVPPNEAELSSTSVLRVAVSSASAKIRAGGPSDDRKDIEREEVTGRVWTGVVPVWEMMGCPVPAGDGVGGEAPGYIVEYVEGRNKREKGHAEEAVGKAYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZS92</accession>
    <name>A0A2T6ZS92_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000121">
        <property type="protein sequence ID" value="PUU78351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZS92"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="373" mass="40652" checksum="90D6212E7452D4B1" modified="2018-07-18" version="1">MPDFSGVRDAIAKHSSDSVLQHPIYPQPKGHLYTTSFYSATEFSEGGVLMADSWGVRHAITKPFYDGFLRDPICPLPKGRHHTSIFHGATESYSYGVKQAITKPFYNGVLRHLICPLPKEHPHTSIFHGATDQIPGALGMRSWSPFTTGFYTIQAVDRQKGVPIQAFSMVLQNSGGVKYAIAKPFYDGVLCHPICPPPKGRPHTSIFHGATESSEGGIPGALGMRSRSSFTTTFYTIQAVDRHKSVPIRAFSMALQSLLKGESLCWCFLNIWKALTLKPDSGGVRHAIVKPFYDGVLHHLVCPPPKGCPYTSISHGATEFSEGGVLMIPGALDMQSWSHFMTAFYTIQAVHHQKGVSIEGVSIALSPSEGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSC0</accession>
    <name>A0A2T6ZSC0_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_911434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000120">
        <property type="protein sequence ID" value="PUU78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSC0"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSC0"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16064" checksum="FBE887736129CB6A" modified="2018-07-18" version="1" fragment="single">FLSLSTDAQQVLVVSVGREGEELALRFSPEVVYANVGDQVQFQFYPLNHSAVQANFERPCVPISNFTTGQGFFSGFRPLPLDTKTITTFTINITRADPIFFYCSQGRHCQRGFVGVINPTPQKSLEAFKASASLAPENLSPGETPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSD4</accession>
    <name>A0A2T6ZSD4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1126746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSD4"/>
    <dbReference type="OrthoDB" id="5425868at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU78410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="287" mass="32906" checksum="1D24AB2992F49FC9" modified="2018-07-18" version="1">MAHKREGGGAQPKIPEDKQGSNKYEPKIEARLETRPQPGSNKELQRLDDWWLKYSQEREQEQKQELQRKSAEIQNLTTALMREKAERVREEGNVVIYKAIEGIVWDSKARGLVSWLNNHELGLYRLSKEPEFTKVLHEEVEARGLVLEDVAACVMKIYWDLLPPPPSYDRNETIVIRDVDFTPEQRAALVTFMKVQDKWEYPRSWREEISGKGPPVTYRACQLPVTCRTRSSPGVTQQIPQYGATAVPTSLSRAVTWTNAKIPVGPWRPLKYCCPTIPDPKTDGPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSL2</accession>
    <name>A0A2T6ZSL2_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_983172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000119">
        <property type="protein sequence ID" value="PUU78424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSL2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSL2"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="50"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU78424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="382" mass="42874" checksum="67242DA12A537DE5" modified="2018-07-18" version="1">MSTTTTTAASLITETLPSTLTVKDESARNKFATPPKYSGALDKYEKFDVTRVIGTEFKQGIQLAELLKAPNSDDLIRDLAILVAQRGVVFLRAQEITLEEQKDLTQKLGALSGKPDSSGLHTHPLTREFSELGDEVTVISTEGKKGLNRRLRPSYKDERSGLASSGWHMEITFEEVPSDYSVLKMTTLPETGGDTLWASAYEAYDRLSPSFRKTLEGLTATHDSPRFAEVAARDGFQLRTDRGAPQNTGLDLVAVHPVIRTNPVTGWKGLFVNKGFTRRINELTKDESDYMLDFLFKHVSENHDLQCRLKWMAYENKNAHDVAIWDNRSAFHTATDDYFDFGGIRRGTMFVSLGEKPYYDPNSKSRRVDLGLGPFSGQFEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZSP3</accession>
    <name>A0A2T6ZSP3_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1126725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000118">
        <property type="protein sequence ID" value="PUU78487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZSP3"/>
    <dbReference type="STRING" id="42251.A0A2T6ZSP3"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="186" mass="20802" checksum="2D7DE7AE18D7AE67" modified="2018-07-18" version="1">MSYKEHEELLLRSKMSLGITDIGSEALRFPQAIAHRGFKVQFPENTLIAFEGAAKAGAHAIETDLHLSKDGVVMISHDATLKRCFGVEGKLIDYDYSYLKTLRTLEAPHVPMPTLKEVLEFMCQPAVLDMWLLLDIKADNDAEDIIRETASAIHSVNPSQEFWANRIVLGCWTLSFLPVCGLSLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT46</accession>
    <name>A0A2T6ZT46_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1126367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000111">
        <property type="protein sequence ID" value="PUU78655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT46"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="201" mass="22508" checksum="ECDD05302FC1E422" modified="2018-07-18" version="1">MSFAFKSFAHQLPLLRYSSNTNLCPHPIEYPGGKWLKQEVVFESMLPSVFVSSHFLTIRANNRFRELLSVVYLEYMKRHSDAAAVSIVGLGMIVNDLNGRSDVKKDLKAKVDAINSHFKKRFSGKNVEHRANMKKQSSDVREVAFCSAYTFLQDHAGNREMILTGLFQIKACHALGGTNSDAVRQIPAASAKQKSVVYAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZT93</accession>
    <name>A0A2T6ZT93_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1141707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000111">
        <property type="protein sequence ID" value="PUU78644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZT93"/>
    <dbReference type="STRING" id="42251.A0A2T6ZT93"/>
    <dbReference type="OrthoDB" id="5499495at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="428" mass="48546" checksum="FC15C1267E7BE363" modified="2018-07-18" version="1">MSQNPRGRPSNSAEYKKHIKKVADQKRYVQRKVDANSISTHSRSKQYQENQSHISNTEVEVPDLPSAGLISSTTSRISSFTTIRNPARWVSEDLEEGVSEKEFENQGREDTIIHNDLQSYKIEENDEEDQELERRRVSAWPKVLGLEQRMQDMDISLEDCFHNSTSTRCLDTDIEKSILEGIGIVQGDSENENNHVENYSSRKGKNVLRISHISDLGHSKLPDLLIDEDIEFQSAEDSGAWIQPTIDSVIFNKFDIIEISSDSDSDKSFSSLNLKDTTNYLIQQYSYNFACSSHTSSKRSTSTTSHSWSIARITQWLNYHLPNDFPKPEVLGYGGRVSSHQWSSLLCGISSESQTPPTLELPIPDLSIATTTTYDIDSFIAKVKCLSIASKGVRVQFNVIHALAARYQYAARCGNHEKMKCLFYYLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTC1</accession>
    <name>A0A2T6ZTC1_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1193092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000108">
        <property type="protein sequence ID" value="PUU78742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTC1"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU78742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="429" mass="48268" checksum="1E8D28BD7EBEBC8F" modified="2018-07-18" version="1">MNPNLGIFSAALHERLQHILLEPEGIYGDRMREFQKRYKNSWYVPLDGYNWDTYDQLFSKGPLPPPWPDKLPRPDIRTTLSSEDVNLDLLFVGHLGKSAKSERCLPRSLAVRARPTATVEAIIDITEVATSDEIRKGQGIPKLPVINQDNVRVEEARRGIKLNVRPNGEAGLSKDPRPLKKLSYAQQKELKKTTAKVGKIEAIRDGKEPKLPRSLPTEEQVRAETRRKIAAMHPVHVDPNRVLPPEGIYSAIIEAIEEGSDQPQGVATGEERSTASASVRKEGDKSAARIWEEYESASPPDAELNPKNKAIPMSLLEMVPKVPRPSLSGPTPLERETNWLTFEWLLCHLFLLWACSVSSALRSLAPSAENILADLPAHQRIPPTNRVRFLEAHGLVNPAMAWTRWPFRDPGSQFEDHIERDFRSKTSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZTY2</accession>
    <name>A0A2T6ZTY2_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1082885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000103">
        <property type="protein sequence ID" value="PUU78936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZTY2"/>
    <dbReference type="STRING" id="42251.A0A2T6ZTY2"/>
    <dbReference type="OrthoDB" id="2134400at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU78936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="13521" checksum="E4E8E2FF57F2FEB0" modified="2018-07-18" version="1">MGKSADKIRKVKAGFKDAKYLNSLEKVGRNELEGNKFQMAVLIQLEGVRMEETEEIKIDSVKENVRRLGEVMEKKDARGGEIIIIEILIKEMAGQHKPTHHRDLAKAVMSHSKNLVVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU29</accession>
    <name>A0A2T6ZU29_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRCT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_980879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000102">
        <property type="protein sequence ID" value="PUU78999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU29"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU29"/>
    <dbReference type="OrthoDB" id="251770at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18433">
        <property type="entry name" value="BRCT_Rad4_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17723">
        <property type="entry name" value="BRCT_Rad4_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17731">
        <property type="entry name" value="BRCT_TopBP1_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059215">
        <property type="entry name" value="BRCT2_TopBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561">
        <property type="entry name" value="DNA REPLICATION REGULATOR DPB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13561:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 2-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="104"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="288"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="381"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="3">
        <location>
            <begin position="539"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="752"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="770"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU78999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="866" mass="95999" checksum="E7250EFAC5D1145E" modified="2018-07-18" version="1">MADQADITRHSHPLSGAVICCTSVPSELRTALAKKAVDMGARHVLDLTSDVTHLICADLATPKYKYVARMRADVQVMGVEWVDAMYDLWINGEDINPLDFNEKYKFPTFQGLAISLTGIQELSEREEVGNIVKLNGASYHPDLTKSVSHLIAAIPEGNKYDFARNTGISIVTVEWLYDSLERGMALDESFYDPKLPQEKIGVGAKPSATVPSRGSVEVSGKRKIRKRAEDTLGSGSQHIWSDIMGQAANPKPKKRDEWGDDPGDDVIMLDHPPPRPQERRLAETAGGKAKGIMSAATFYIHGFKDKHEKTVRSVLLSYDATIVSKIEDLESYRESSRLIIIVSHTISKPNCPEFPGVEVVTEWWLETCLHESRFAEPSEHFTNTPFEEFPLTGLGRMDICLTRFTGIRLLHYQKLITLLGGSFHAVLKKERTLLISNRPATGDKFQFALRYDIPVVSDDWLEACVKEKRVVAFKDYLIQGQRLESRERSWLRIPKGFDRRRTRRPDVPGDGGIGAKAWGGAKHDRDEIVVDDVACSNEKKQRILHGCIIGISSGLKGRRADLDSIAKSMGADVVGSFSSEDLTLITHFIDTPEVTRKSTKDFEAAREIDNCHIVSADWLYNSEKHGRRADEKAYSLMQPRGRGLEMDFGKSSSLSSLDSAMVRAPSQGFDSELMPPPSDEQGFRRGESLENEGNVLSPLGTVSHILLDELHNQSTHVSQASISALSPAEQADIERRNFVGELLGKLGKDAITSAMGRRKRPRGKLQGRASSNLSSYSNNSTGGSQGEGARRGEFDFSSPSRHEVEPPIPSQAITYTDPEAERERRTVRAKLSGNPVESPKPVGRIGTAVDVEVTTTAVTRRRAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZU81</accession>
    <name>A0A2T6ZU81_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative 60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1047406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZU81"/>
    <dbReference type="STRING" id="42251.A0A2T6ZU81"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="175" mass="19954" checksum="26C4B45D85C514D6" modified="2018-07-18" version="1">MADTKSKDTNPMRDLRIEKLVLNISVGESGDRLTRAAKVLEQLSGQTPVYSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEIIERGLKVKEYELRKKNFSETGNFGFGISEHIDLGIKYDPAIGIYGMDFYCIMSRPGLRVAKRRRCQSRVGASHRINQADSIKWFKAKYDATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZUC7</accession>
    <name>A0A2T6ZUC7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_18449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000100">
        <property type="protein sequence ID" value="PUU79086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZUC7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZUC7"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="166" mass="18409" checksum="75FBE8DA0CA352FA" modified="2018-07-18" version="1">MTIDDPAQNQQLLLPAPLTFFHAKIPFKHWQLRSLLCSPSPNTLYYPTDNNVYSLNPATRKREVVATLPFSPRCIGAKYGWVCAGGVENGQFASIRVRQQDKSSDQRRGDDEVEEGEEARESTSGSQRRISPDIKISQLGGLIVNSVTLHRPPSSKSDDDVLAVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZV40</accession>
    <name>A0A2T6ZV40_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_1047045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000094">
        <property type="protein sequence ID" value="PUU79368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZV40"/>
    <dbReference type="OrthoDB" id="3801555at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU79368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="174" mass="17856" checksum="23D1F5A1028AC132" modified="2018-07-18" version="1">MEEGLVEGNLIEEGLAEGNLAEDGQMGEGLVHGSLVESNLIEEGLAEGDLMGEGLVHGSLAEGNLIEEGLAEGNLAEDGLMGEGLVHGSLVESNLIEEGLAEGNLAEDGLVGEGLVHGGLAEGNLGEDGPMGEGLVNGGLVDKIQAQLAEEERAVVGIESGRECHQSWRQLRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWJ7</accession>
    <name>A0A2T6ZWJ7_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1045931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000080">
        <property type="protein sequence ID" value="PUU79846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWJ7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWJ7"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF3">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_7G06200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU79846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46826" checksum="FE973A34D7E8B9DE" modified="2018-07-18" version="1">MSSSTKHQQEVNLGDPDSPDSDFPEEENGEPAVENLAIGNLGIDKLVAERLAAGTLAAEKLVTEKLAAVGLAAEKPATEKLAAEKLAAEKLAVEKPAAEKSVSQESEDKFIPTGEEIGKRLKNLIKSDRKGLQKIYPGDDAELDKILKAPTERGEEMARKLVMEMGCSGEIAKDLTVLTLYDVAILIDDSDSMIGEENGKRKKTLIEFVDHITDIYQMANKSGILAMRFLNGSRGKKNWTGRSQKYLDRHTYSGLTKIGTELKEKILDIYAIKNAKQSKPLLVLIVTDGAVEGERKGHLKKVIRDCVNERERAGKGFDAVSFQFSRIGNDPGAAQLLIDLDEDTDLGEFIDVLPVEFDLERQLQDKWFVLPKILLGAILPGWDKQDDHHQTEEPDLVADRVKDSKGPADFLEDSDDDDENSGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWL1</accession>
    <name>A0A2T6ZWL1_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B9Z19DRAFT_1107387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWL1"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWL1"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="548"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="747"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="830"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1091"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1203"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="462"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="529"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="966"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1208"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1251"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PUU79875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1266" mass="140385" checksum="E575E6FB4E5001E9" modified="2018-07-18" version="1">MAYHEVTDTMSESHVSLPSNIHDPESDRLRLGRELARDFAHDSFSSNLSRGGANDNNNDEETDTLGSFDISRDARGTSTRRVDMLQHTPTIDSQLFSQEFADFTMAGRDGDDEEVTDSIEVGRGDNNNSDLRSVDFSTHIPFPLTAGRGRKQDRKMSSFFSTVSPNPPARLQSVSSTHSDPSEYLQASRRRGGASTTNNKPKEKAKPGQESKGLGGLTGFDLSQIGTPKTNSRGRSRLGTTGIGTEASKISDFVSNSGSGGSRSRFQGGQSKSPRDEHGDTASDVGSVSGRARPSNTRFASSKSKQSSSSSVPGGGARGNRMGKDDDLTADVPAIVAKARRTGTGTDKAVPQSFKSTDAFLQELGLDGHTTTTDLKERLDRLKDVDAGRAPGFYKPTDEAIGITQQSFLLPQMSDLSELISGHPGDATRFSRKHTARGFSKTHKPLESIPVPHDERAILMAMKLLQDKVEALEGSKAEAEEQCMHLEHELRRSETRLRQEQHRARAAEDGLIRKRGGDSAFGGSNDGDAEERAKEKMKLEHQMEKLKLETTINSLLTQLDMLTRELEISKIALRHMQEERNSAINSVAMAISTNEDLKTVNEELRIEIAHLRQGRSDYDLKDKEWRIHDDRLRRKTREAREAAAVAEVVTRDTARRGKGKEVAANEESAMAERREQRAREKEAEKVRERLDIQEEKIAEEQRAKERIALQKERVDKMVEHQLRKLRPDLFMSKLDIPAASSLTVNRASVPEPVRKRREGARAQRKGKKDTRSNEARGYPATSDSEASPTDAPDTQVTARNNRPKDLSTGDDTVMSISPEIKRIAKEIYAERRKSKAAAASTAHEPAPSGRGTKDHTKKAVKPKTSIKKSTKTSAPSTEKAEETIVPVSREPGTSNKPTKTVRIAKSAKSGGKVVDSSAQVTATLLAQPQAQPQASATASSDAAAQASQASRRPRRRRIVKKVVYYYDEETTMSFPVEEEVEEEVSESEDEETKAPSEQARQGSPEPGRDEEHTSHEEMSYEDPMTLHESMILPALTAPQVATQPAPRETHDAQSMVDHLAEHDDPESCTVCRRMQGLRQKEQEQKMANPLADIDNSMAFPAPPLEPVSTRRPENAGPYEEEVTPRPSQEPKAQLSKLVRQLQDEFVHIKLAYQNKAEEFMNLDPSMGKRRRKTLTGEINELVAEMDYKCDQIYALYDVNEEFCGRMDSEDDEDDEEEEEGEEEGEEEEEEEDEGDLTEWIISESLVLENGENGDSEDSAGDEEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWL9</accession>
    <name>A0A2T6ZWL9_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B9Z19DRAFT_1100580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWL9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWL9"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PUU79885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="170" mass="18362" checksum="1B98424C3272AF1C" modified="2018-07-18" version="1">MAVCGICREAESKYKCPACKVPYCSLACYKPHKVEHEANPLPPPLPEPPAPATTIPEAGLEVKDPFAPLLATPLTPTLRKHLLSIHAATQKPTYNSNSNYRGRGGSGGRGRSGTGGGGHETHEREWTEEQGTKAAIEKLRKLRARGNEEIEEFVHMVVGLVEKGQSDTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZWS9</accession>
    <name>A0A2T6ZWS9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ANTH domain-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1100579</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000078">
        <property type="protein sequence ID" value="PUU79884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZWS9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZWS9"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="13"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="493"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU79884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="679" mass="74938" checksum="19514D3AEBD09DB9" modified="2018-07-18" version="1">MAASFEKSVKACVKLRSIVAPGVAKMDGGEDWIKLAAPKSKYVEHILIATHAGEAGIAEVFRALNNRVKDQTWTIVFKSLIIVHLMIREGEREVTLRYLRKHPRLITVSHYSDAQEQGRNIRHYSQYLLERARTYGDVRTDYVRSGEGRLRKLSIEKGLLREVECVQTQIRALLKCTFLDDDVDNEISLLAFRLLVMDLLVLFHVVNEGVINVLEHYFEMSRYDAERALEIYKTFTKQTADVVEYLQQARGVETATRLQIPNLKHAPTSLTSSLEEYLHDPDFDVNRRQYLAQQEAKKSGKPIPATKPKSPPPGQQSKTLAAQRFPSPTPANPAPEQAQPKPVAPDLIDFFESIESEQTPMFSNQPTNGQQIQMPQPQNQFPQPAQVDAAFGIQMQQQPVPQQPFVAPPQQFPTQTGSGSGFGTSYQAQNPYNQVTQQQPLPSIIQTNNLPTIQQPNFTGTGFGGYTPSDQNAVTAPLMPTIPQLFTQPIQQPIQQPSYQQPQQQPQQQQQQQQQQQQQSLSPVVSLSTGATDTNPFRQSMMMTGSVSTASSLYATSPPVVAQPKSTNPFARQASPTNLSPTSPPSAYPISTQSTSAYPQAMPISAQPTVRSMPTGTNPFARSVSSAGTGLTVPANVTGASVTNPFRQSIMAQQQQNGGAQGAMGAWEEPKNSTGFPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXB5</accession>
    <name>A0A2T6ZXB5_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methylenetetrahydrofolate reductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B9Z19DRAFT_759846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">Tbo3840</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXB5"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXB5"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="398"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PUU80131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="563" mass="61999" checksum="05F9B74A8075709F" modified="2018-07-18" version="1">MDKVVNKIAALPPGEPYHSLEFFPPKTAMGFQNLQARLERMARALRPLFVNVTWGAGGSTATKSLELAEICQRQLGLTTALHLTCTNMSQAVLDETLEAAKEIGIRNILALRGDPPRSDDYHNTPCDGASNGARKEFEYAVDLVRHIRERHGDYFCIGVAAYPEGHVEGASPEKQDPLFDLPFLVEKVKAGADFIMTQLFYDVDKYLWFEKLLREEPSGVLSELPVVPGLMPIQNYSMLKRITKLSGASLPAGILQRLDDVKGDDEAVKQVGIDIVSEVIEKIKAANLSGPRGFHFYTLNLEKSVSFIVERTGLIPPRDESVFEEIEGPAVNGVALRRDRRTSSVTSDPHNRVIVDNSSSLQSPRLANALEAGFLGPPEQSRPPEVALAISEGEGALGREATWDDYPNGRFGDARSPAFGEIDGYGPSLHLSQAQAIKLWSCPVNKQDVSDIFVRHIKGELNAIPWSEQGLSVESKVIADHLTKLNQKGFWTVASQPAVNGANSTDETFGWGPRGGFVFQKAFVEFFCSTEDWEILRAKLEGVEDVSYYAANKNVSRSSPRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZXF9</accession>
    <name>A0A2T6ZXF9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B9Z19DRAFT_1124039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">Tbo3840</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000072">
        <property type="protein sequence ID" value="PUU80115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZXF9"/>
    <dbReference type="STRING" id="42251.A0A2T6ZXF9"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PUU80115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="209" mass="24197" checksum="44F52BE9E56B7823" modified="2018-07-18" version="1">MPRRTSPPPEALATPEYWDTRYTADPTPFDWFRNPTSIHPFLTKHLPPPISNPSILHLGCGNSLLPEDLHKRNYKDQTSIDFSEVVIRDMKAKYEGFEGLRWEVMDVREMRGVGDGKFGVAIDKGTLDAMLLGSLWDPPEEVRRNTKAYIDEVARVLKSGGLFLYITYRQPHFVKPIITREDVWPDFEIESIQEEGGMFEYFGFVMRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY71</accession>
    <name>A0A2T6ZY71_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1172230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000067">
        <property type="protein sequence ID" value="PUU80375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY71"/>
    <dbReference type="OrthoDB" id="5388946at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="641" mass="69149" checksum="0FBE097FF67694D5" modified="2018-07-18" version="1">MAPIVIFSKGGRERPTGGRDSIMGNYRIPKKIFTSAEEERKRQRLRDTRNLATGIEIALKHLLPNESQVVKKAVWNTHDSLAVDIELGVDSSRTDFLGARIVDRATPTGPARKNAGAYYGRPKNGGGGNVHGVPSAPRAMTRYWSVLDQGKFPDHPSQQDSRYINGSIGVPCATSSAIATDSNNGQPLSGTSGSTTHRYLQDPSDPNRLIGVPRPRLPIWATRSNHGKSDSEKPARISYPYLQDPSDPNKFVGVPRPFDWKDQNTKSDKYNGPAFHEHRRRQIELGIFPSMYPDNWISGETFGDDDKDISSAKRLYEKEQGGIRNSGVDRDGDVAMSQELETPEPIPRSVLPTPVNSACGSLVQVFDGFRIEDEVVLETAETVKASQDFFAEVESEAAPVGPATPPAASEGRSDNDEISSLVNLVDSKASGTASTSMLSRIDVGSSTNPLLASRIEKMQPFRTSSLAGSSYAPTVLSARSQKPFGGYGTSNYSAASKAPSTVFSYAGSSASRNCLFDTMIDSVLESAIDIPVLEPTPASKSSLFAGHASNLRVPMSHNEKVSQWAASIIPNGSPNSQPASPKKFGSTSKTPVEYIFPRKGLFGAKNSIPTRKPNNFFSNDLLEIAGGGNGDTQASPSNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZY79</accession>
    <name>A0A2T6ZY79_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_975082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000066">
        <property type="protein sequence ID" value="PUU80410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZY79"/>
    <dbReference type="STRING" id="42251.A0A2T6ZY79"/>
    <dbReference type="OrthoDB" id="3433692at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057203">
        <property type="entry name" value="DUF7881"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25324">
        <property type="entry name" value="DUF7881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7881" evidence="2">
        <location>
            <begin position="9"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="293" mass="33671" checksum="B429D14B631A5866" modified="2018-07-18" version="1">MQSNNRADGRDTFIYDSNHRDTLLGGLWVAEGITNANLYCMVDIICLFDDTFHIYDNNEKLVERDEKPLQPGNYFIVYNGSITLTEEAPLLRALSLHSGSRIKSFRDAVRERDRRCVITGLRSQRPDRWGWDFFEVAHIFPLAYEDHWNQSNYSRWITVPPANESDGSIHSVQNGMLLTPNMHALFDAYIVSINPDDNYKIVGFGPEATDENIAGRHLDQTFLNNPLRPTDQLLRWHYRQAVLVNVKGLGEPYMENDFPPGSDIMTEIMDGPKAAERMEYELFSRFNAMGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYA7</accession>
    <name>A0A2T6ZYA7_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B9Z19DRAFT_1063436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000064">
        <property type="protein sequence ID" value="PUU80459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYA7"/>
    <dbReference type="STRING" id="42251.A0A2T6ZYA7"/>
    <dbReference type="OrthoDB" id="10636677at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015761203" evidence="2">
        <location>
            <begin position="21"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PUU80459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="921" mass="94048" checksum="17D81C0EE4B5B86F" modified="2018-07-18" version="1">MWGRYITTGAILLLAATTNGLPLADDAHLVMGGHYKTNLGKRTEPVTPQTQPGHGLPPPTLPPTTTTLHVSPPGVTTQLGAPGTTGAGGQNPPVGSGAVGQRPSVPGGNSQPMPSTGSASNGATPTPHTHLPVGQGQPGSLQPGTTSGLGSPSPTGVKPGGAHEEDQNTPPKNTNSKPQSRTSSSSSSSSKPKPKATGYTDLPGALSSPGGISANGVPTGVAPVPSPPGPEAAKPPASTGLGDVGTSIVPGGVSSTVTSVPGHIRSTVTPSAGPPVGQGLQSPTGNSGQQFVVNPLNAPLSQTVSTPLGQVSPLANPAVQNPSLPGSAGPTLTQPLGATGSQPPAFQRVPALARRQQVNGLNPEKTSTTSTSTSTKPQKTKTVEPKPKEEDSSPELRYELAEDSAGDKPETVGVSRSSSRKSSTTTRTPTPPPVMNNEQPAPQQPGGPQPNNPPVWIPPQLLYESVGGMIDTPVFYPNIYPPPNPGPVVMMNENTRTTTRSTATSTSPPAPTGSGPTLVHESIDTQDPDAAVIKAAPLSHDLPSTRKVHGRHGADLPLYENVGPTSEKPAAIGPADSKSTTTTYTPLSNTLPPNTVIQTTNPALLYESSGDGKDPVALPVIADSRTTTSATTGSSQGPSLKYEYGPGDNYPGAGVPAPILPTQTGPTDTVHTSAQPTGGGPALKYEFAGAENQQSSAYISTVTTTVYQPQPTQPPPVLKYEYVGAENLVANPPISTTTITHTLTTTPAPGGAGQPGLLYELAGNGDPSPVDVQSTTTSFVTSYTTTTPPTSTTPIPQGQQQPTKPLALRHGNEGQGVTDTRVTPSPTGGPSSHLSSQHEKRHEQGSPEEKVPSLMHEAAAADPVSSAPPNPVDIIDTDGTHPRRKRNEVHRRGFVGVDGVASAHSPADHGKRVRRSRQFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYK4</accession>
    <name>A0A2T6ZYK4_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B9Z19DRAFT_893901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000062">
        <property type="protein sequence ID" value="PUU80578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYK4"/>
    <dbReference type="OrthoDB" id="10386454at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PUU80578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="99" mass="10574" checksum="4DE709B328FD6F5A" modified="2018-07-18" version="1" fragment="single">FGPLVTIELHTLLQGCGSVCCQYFAVPAVNHFFFVYLLEYVGDDFSCAVVVAISSNPSYAVPCGSSDGPAHLIVINAICPSHRKLATTSVPFCLSLCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZYW8</accession>
    <name>A0A2T6ZYW8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1100160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000060">
        <property type="protein sequence ID" value="PUU80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZYW8"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="100" mass="11011" checksum="BD6422FB096E8C42" modified="2018-07-18" version="1">MAVNDSAHPEFARTAQDVEGELASRRPSSSDSFHGGRGGVGNVVHSTDSDLVRLRHEEEERDRLAAEVAKPAPIDHAKIDYRGWADRGKDFLKEKMKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T6ZZQ0</accession>
    <name>A0A2T6ZZQ0_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_673061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000053">
        <property type="protein sequence ID" value="PUU80972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T6ZZQ0"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU80972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="207" mass="23314" checksum="6632ADC65B06C69E" modified="2018-07-18" version="1">MNLSTFAITAPSLLEYRAHTVHTTAELTLWYHQATGIIHPIHPPIEIRGEKNTCFEPFITVPVPVLVFLLSIFAPPSALSVSNGECVGVLKVVKLWIMPFFFFLSLEFHKERYGMQRVDGCQGWLVIADGGRVFIGGALAREPFGVIEFKVLGAWCGWVFIGYARSWLTSSSGCSFLFFFFHFFIFSFSLFFFGGWEGGLFVACWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A006</accession>
    <name>A0A2T7A006_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000051">
        <property type="protein sequence ID" value="PUU81079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A006"/>
    <dbReference type="STRING" id="42251.A0A2T7A006"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="146" mass="16146" checksum="5F75A855B1EFC675" modified="2018-07-18" version="1">MEQLSVLLLDITRPLTFLLKREKKKPSEQKPAESVAEAEPTTMEPANENTTVAPETSAAATAEGQSSESKDGASNTDRKKDDDMRRRLRHLVPPVSPEHNLRLVVNILTARECSSKTFRETLSIMQNLSAIPEGKVFFGADSIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A049</accession>
    <name>A0A2T7A049_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1122519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000050">
        <property type="protein sequence ID" value="PUU81106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A049"/>
    <dbReference type="STRING" id="42251.A0A2T7A049"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015723160" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="16734" checksum="5E4055017E914EE3" modified="2018-07-18" version="1">MKPTLIVAVSILSTLASGLALQDLSRRGTVIRPEIAVLVNEDNPFTTIPCPVGIAGVTRWSGAHTTRALLGFVVPPAPERGYPACGNTWNSRPWLDVHKGSFLALDGPVPATVVEDFGLTFPCRATTTRLGFDVSPIGDNDYVIWDITKGGFIITCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0T8</accession>
    <name>A0A2T7A0T8_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dopey, N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B9Z19DRAFT_1122255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A0T8"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="348"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="11">
        <location>
            <begin position="952"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1299"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1394"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1397"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PUU81362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1793" mass="198016" checksum="47EC8F786F97BF5C" modified="2018-07-18" version="1">MSLDPGSRIPSPLSSGRSSPQPRPRFRNEDEITRKDPKYKRYSTTIDRALSLFESYSLQEWADYISFLGRLLKALQSHPSLPLIPSKALIAKRLAQCLNPQLPSGVHQKTIEVYSYIFSIIGCEGLGADLTLWTPGLTPVLSYASLTLKPHYLTLLERFYLPLATALRPALKSLILALLPGIDEEGGEYFDRTLTLMDEIRNGVCDDAYFWQCFLLATITSPGRRQGALAFLGRRLPKLDSEEVGDNLESGGSDAEALVSPEPGLLIRAFCAGLNDEQILVQRGFLDLLVGSLPLCSKILQERVSKPDLELLITSAAGVVLRRDMSLNRRLWAWYLGPEGQERRANDYFGKYGLYALIGGLEKMLDQPIGVSSAERAKPYRICLSLMDRWEVGSLVVPKLFLPVVESVRQYEKSAPSKEVYTEVLKSARMFFDGVEASLIWGQILEKVTQAFSAGEGREAEEILESVRFVIRTFNVNEEEMVVLHTPLLVLATLVELGKVSGGGPGKALQAKGFRIAEALWRMVPESVFKAIPAQVASEPEHADKAMIIEGIQQFYRQSGGSPAGPPFSIRNVGQWVLQEAARAAQSALTSPENDEDIRVRCHLLVSVIQKIPQFQCWKESTQLTQSFLAVLSNPVVSFAALQGIANVVASLYIKSYISPHDIGSLILPIVRNIWGYLSPDRPKFHVEAVKAIWNLQMVLADRKIEAAIATVMTEGDVGGVYSARNAENGRKFGVLWMHSSNHPSGASGLEMVLTRPLFLFLDALGDDGLEVAVFARGWLQNLGTVYRLFSVFITKLLGLGFLRDPGQRDVNGAPIRRQPFGEDDDLEIATYYFQTLSNILQYSTNTVLAALASELVIGADEARAKALVEAGYGEDDMTLQTFFVKAAVRAIEGDAKEKKDVERVSRLHRIALKVLHQLLLSPFVKPLVDMELENVLTARLISALDVADTYVQVSLLDVLFAALKLSLMRPASQLGQFKKDTGSIKGGRAPISVETEKTMVAPPRAIPPQQLLKCLVGGFSSSSSRPVLDSWVNFLTECLPLLENVIFQILMPLVECLCGQIRQAFHALKQVFEQEEHNDLISLVNSPEGTLVALLHGLEQILGAAHDKLVNEEIKSAGANTKSPDAPTASTFFGNMVSGVFAVESPQHRSSAANNRLTVLLCFRDTVKSCYAIWSWGDSSAITGESELDPGSKESWQYVSVRMRGRARRILEHLFGAETLECLETLIELWPAKPTLTSDVKKTGDIFRLINVLDGSRPKHTIPAIFNAIYSRTNPAALEPNRKSALTAELQDLDVVVFLVEYARSLEDDAMDEIWADCMVFLKDVLANPFPHRQTLPSLLSFTAILGEKVDNTNFGEQRRMRKELGDLFIRLLTAAFTVKPIGQNVLESPALAAAGDKDRERGGGKEGDGDNKGDRTSKGKTSPVDIVGVLVSTVPELRKVLVEPDRVVAASIAISANVIGPTFRSKSFPHNVTGGVLDLLYQLTRLPNNQKAWKKELSDAFLDPKFFSSPISLVKSNWVPLARQFLVSERERMTELLGRITPPTTAGVLFGVGATSARQETDKKTQLNLRRIAFLILAAEMDTFVVNLPELEEKLVELLSATAVTSPSSATRGDIYLVFRALALRTSLVHISSLWPLINTELQSALSSLFPEEENDIHTDSSILQACKLLDTLLVIAPDEFQLHEWLFVTDTIEAVYRPNDWNPTALVDQVASELPSSSSHGTIVENRRRPWLAGDHVRELEKSGGDIRSELLRPFLSNLSIFVYEATYGMKPPDMGACEDAVLRDLFSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A0T9</accession>
    <name>A0A2T7A0T9_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B9Z19DRAFT_971856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A0T9"/>
    <dbReference type="STRING" id="42251.A0A2T7A0T9"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="308"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="648"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PUU81349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111454" checksum="AE51C36A7F3355B4" modified="2018-07-18" version="1" fragment="single">MDCSKFDQRFLSSPLISSLPPDAISIISGSARVDNGLYLDTLSRIAIDPNFTSLILICYEPIFTDLVARWRGFATVEQLAAGFARVLPVVPFLADFAEEFLLRSGPGEAAPGFLTRMERLSDELRLSELSTVDHGERSLDMLLSLHRLLCFRREAFLGLVNADVLFGLMRHEYLPVRYLSVRILSIYLKAADRAQEAMFSRFGVGGTAKEKVLGLWEGREVDYGFLMLLEAERLEKLSKDLETARPVNDEMSIGNSRVINSSDLSPLAADLCGVLIPRLRGPPSQSSSIVDTHTTRKNINSIAQALRSPRPLLITGQSGSGKTYLVHQIAQVLNTLNDMISIHLGDQTDAKLLVGAYTTTDAPGSFEWRAGVLTTAVREGRWLLVEDIDQAPKDVLSVLLPLMERGELVIPSRGDKIAAARGFKLIATIRTAPSIKSDMVAMNSLGSRLWERVNVEMPSGEELNTIIDSRFPLLVGISPTLMDVYHDVQKTYSEPSFFAISKTSLGRLISPRDLMKWCKRVHALYISVGIATSHEPLSDGVFDGIFMEAVDCFAGSLQTKEARTLIVKRVASNMHIPSQRIDLFLGGGHIPGYSDSERILVVGRVKLKKRKKEPVGPKRRRGYAQRRPFATTNHAARLLEQVGVAIRLAEPVLLVGETGTGKTAVVQQLADMMRFNLTVINLSQQTESGDLLGGFKPVDMKTLAIPLKERFDGLFEKTFSLKRNKRFLDALNKFWSKQQWNRVITLWGEAVKMADQFFAAPKVEELEDKPAKKRKLDDVDRPVLQAKWTNFANDLSNLEKHNSQLDKSFAFSFVEGSLVKAARNGDWVLLDEINLAAADTLESIADLLKDGGGGSILLSEKGDVERVKAHPDFRIFACMNPATDVGKRDLPPGLRSRFTELYVTSPDQELSNLLAIIREYLGNLAVGDDIVVADIASVYMEAKRLSEDQQLVDGANQRPHYSIRTLTRTLSYVFEIAPVYGLRRSLYEGFCMSFLTLLDQASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A114</accession>
    <name>A0A2T7A114_TUBBO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B9Z19DRAFT_1099789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">Tbo3840</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000046">
        <property type="protein sequence ID" value="PUU81375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A114"/>
    <dbReference type="OrthoDB" id="5379885at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PUU81375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="568" mass="60942" checksum="39F49F8A961B1048" modified="2018-07-18" version="1">MEGWLQVPPERNLMGRALWKIRYVRFGPNSSTAPTKSAASPTRPSIAAGAGAVVGVPALTIGGSNSSGVGGKGTYGSERKSHFAGSNIAGGINNGIGGGGQESGQLPIYLSIYKQKNDAEPVMRYPLSSISSCYIGDVAARHKKKSIVLPTLVINLRTEPVLSSSRSFRRRSHDVPLKESAKRELPGKETLLFRPGSETEPLERWAREIQSCLIPTSSHSNRTVNTLESAFQEKFSDPDDLPGSSSSLFIINGEPTTALLSPSLRSRASNLSSIDSDDNGSLLSSPASEMNSPRDPDIADRRPSLHIATKLRHYTSPASPDITSTDSYHSMHAAFLNPTRATSPTAGAVPARRETILDRFFSTAPSSPTSVPIPMNSIARFEALIEDMESGELRAPDESLSIRNYPRRIPSPTQRALEYVSTGYLDESPPSPTSSSSSNSAMDPVHTTHLSPDDPRLPPPLTESLGLTLSRQPSEASLGTTASIANSQAENQSQSLGVSNGKRHSLADFSVMRIATPPLFQIAASRRGSYSDIPRTSESYDDGPAPLASSNFSSHPRVARALFREFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A164</accession>
    <name>A0A2T7A164_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B9Z19DRAFT_1062608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="NESQ01000044">
        <property type="protein sequence ID" value="PUU81476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A164"/>
    <dbReference type="STRING" id="42251.A0A2T7A164"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="380"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="656"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="290"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="665"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="767"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PUU81476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="1146" mass="128799" checksum="E7F1B7D6D567348B" modified="2018-07-18" version="1">MGNVGSLLTAPPKVSPGTEIIIALMGVTGAGKSYFIREVSGNSAVEEEGTNKVQSYSFEYAGARITLVDTPGFNGMNRSDTKVLRMIGDWASEAYRNDQLLSGIIYLHPITHTRMEGSILKNLRTLQSLCGQEALENVLLTTTQWSRVNWVEGEFRENRLRIREFWGGLIEKGATLQRFAGTRASGLELIHKLMLNKPKPLHIQNQMVKQHMTLFETDAGKCINELLVGQKKKHKEEVESLSLEHQEAIKAKEDEMNEILAAEQAKALEVAAAEKELLAESHAAEVKQREAEERERREEATAYIKSLEKQLAVEQAKAQKKLEEVVAEKEFLVESHAAEVKKREAEESERQEEAEAKTKLLEEQLVAEIKKRQNEALGKCGLSNLGNTCYMNSALQCLRSVAELSNYFLSNKYTEELNPGNPLSHNGKVAKAYAALLGHIFSPTCPGSVSPREFKSTISRYSLSFSGYEQRNTREFLEFLLDGLHEDLNRIQEKPCIEKPESTDGMVGDSEAIAKLAQEHWSIYKQRNDSVIADLFGGLYQSTLVCPDCEKVSITFDPFMDLTLLLPVENVWGRDIYFFPSSASGKGLIKVPVEMDKNSSIKSLKEHFARKFNLDPKKTMASEVYKGKFFKHYEDFQTVSETIRQDDDAFIYELDDAPTNYPPSKGEKTRRAGVHEPSDAQFDDDDDVPDPGAPECDRLLVPVFNKVQKQNRYGIGSTAEVFGFPFFIVVNRDERRSFDAIMKKIIGKYQVLTTRNFYKSEASPNESETEEAVEVKDELEDMNETEEETDDRFVDVSMKDASSMVGSDRKTAKSPRRSLPTGIQDLFTVKVTKRRSGDSAVITGWQSLETGFDIRERLNREQSASPLLMWGEGLICEWSIEGYDSMFGGESKDDLRGVPLYNSVPLVQDQELERKRKGIHLEDCLDEFAKEVILSGEDPWFCPRCKVHRRASKKFELWKCPDILVIHLKRFSSSRNFEDKIDVLIDCPVASLNLQERVGLKEEGKSLVYDLIAVDNHYGGLGGGHYTAYAKSWIDNKWYHYDGLFTLILHFKTAKITDKFIDSSVREVNEQKVITSAAYLLFYRRRSETSLGGPRLNRILGESTNSPGSASSSRNTSPSRAGEGGLSGNSSATVLLNGRSPGGGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1H8</accession>
    <name>A0A2T7A1H8_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B9Z19DRAFT_971471</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">Tbo3840</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1H8"/>
    <dbReference type="STRING" id="42251.A0A2T7A1H8"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="5"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PUU81584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="119" mass="12903" checksum="7CFE52DD79EBE499" modified="2018-07-18" version="1" fragment="single">NFYSRSSKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVLPNIHQNLLPKKSGKGTKGASQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A1I4</accession>
    <name>A0A2T7A1I4_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B9Z19DRAFT_1076720</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">Tbo3840</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="NESQ01000043">
        <property type="protein sequence ID" value="PUU81525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2T7A1I4"/>
    <dbReference type="STRING" id="42251.A0A2T7A1I4"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PUU81525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000244722"/>
        </source>
    </evidence>
    <sequence length="352" mass="39007" checksum="1FD69705F6C0338B" modified="2018-07-18" version="1">MASTGGLTRRRGGGGGGGGSAGDEADRSGSPSTSRPAEPRSGGGETSFTTENGHKIAFDPRDISENQERNKQPKLTLMEEILLLGLKDKQGYLSFWNDNISYALRGCIVLELAFRGRVSMQKDSNRRRFPLSDRIIEVIDDTLTGEVLLDEALKMMKASEKMSVSSWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKDEIRRRVRNVLTSRTVVLPGNPFLPEDLEFRYLRTVAMVCAAYAANVLENALATLGHEARERAFSHVDELLAEFSQWPFAKRNTASGVGQNLGTATTEELNKNKDRELQIEVVAAVLNVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-07-18" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2T7A222</accession>
    <name>A0A2T7A222_TUBBO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">B9Z19DRAFT_970716</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Tuber borchii</name>
        <name type="common">White truffle</name>
        <dbReference type="NCBI Taxonomy" id="42251"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Pezizomycetes</taxon>
            <taxon>Pezizales</taxon>
            <taxon>Tuberaceae</taxon>
            <taxon>Tuber</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2017-04" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequence of Tuber borchii Vittad., a whitish edible truffle.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Murat C."/>
                <person name="Kuo A."/>
                <person name="Barry K.W."/>
                <person name="Clum A."/>
                <person name="Dockter R.B."/>
                <person name="Fauchery L."/>
                <person name="Iotti M."/>
                <person name="Kohler A."/>
                <person name="Labutti K."/>
                <person name="Lindquist E.A."/>
                <person name="Lipzen A."/>
                <person name="Ohm R.A."/>
                <person name="Wang M."/>
                <person name="Grigoriev I.V."/>
                <person name="Zambonelli A."/>
                <person name="Martin F.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">Tbo3840</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="NESQ01000039">
        <property type="protein sequence ID" value="PUU81783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="42251.A0A2T7A222"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000244722">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
   
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